CN102643344A - 结合构建体及其使用方法 - Google Patents

结合构建体及其使用方法 Download PDF

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Publication number
CN102643344A
CN102643344A CN2012100806998A CN201210080699A CN102643344A CN 102643344 A CN102643344 A CN 102643344A CN 2012100806998 A CN2012100806998 A CN 2012100806998A CN 201210080699 A CN201210080699 A CN 201210080699A CN 102643344 A CN102643344 A CN 102643344A
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polypeptide
cell
immunoglobulin
albumen
heavy chain
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Chinese (zh)
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J·A·莱德贝特
M·S·海登-莱德贝特
P·A·汤普逊
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Aptevo Research and Development LLC
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Emergent Product Development Seattle LLC
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
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    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K2317/00—Immunoglobulins specific features
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
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    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Peptides Or Proteins (AREA)
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN2012100806998A 2003-07-26 2003-12-24 结合构建体及其使用方法 Pending CN102643344A (zh)

Applications Claiming Priority (2)

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US10/627,556 2003-07-26
US10/627,556 US7829084B2 (en) 2001-01-17 2003-07-26 Binding constructs and methods for use thereof

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US (3) US7829084B2 (https=)
EP (1) EP1654358B1 (https=)
JP (2) JP4904443B2 (https=)
KR (1) KR101163240B1 (https=)
CN (2) CN102643344A (https=)
AP (1) AP2006003527A0 (https=)
AT (1) ATE525399T1 (https=)
AU (1) AU2003300092B2 (https=)
BR (1) BR0318417A (https=)
CA (1) CA2533921A1 (https=)
CR (1) CR8257A (https=)
EA (1) EA200600313A1 (https=)
ES (1) ES2376751T3 (https=)
HR (1) HRP20060074A2 (https=)
IL (1) IL173322A0 (https=)
IS (1) IS8305A (https=)
NO (1) NO20060764L (https=)
NZ (1) NZ545316A (https=)
PL (1) PL381765A1 (https=)
RS (1) RS20060055A (https=)
TN (1) TNSN06029A1 (https=)
UA (1) UA90999C2 (https=)
WO (1) WO2005017148A1 (https=)
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Cited By (8)

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CN105658664A (zh) * 2013-07-31 2016-06-08 美国安进公司 含有Fc的多肽的稳定化
CN113512109A (zh) * 2021-03-09 2021-10-19 北京康乐卫士生物技术股份有限公司 一种抗人乳头瘤病毒31型的单克隆中和抗体及其应用
WO2022078466A1 (en) * 2020-10-14 2022-04-21 I-Mab Biopharma Co., Ltd. Methods for mitigating interference by therapeutic anti-cd47 antibodies in pre-transfusion assays
CN114591988A (zh) * 2022-03-30 2022-06-07 北京贝来生物科技有限公司 一种激活肿瘤免疫的基因修饰干细胞制备方法
CN115286701A (zh) * 2022-03-07 2022-11-04 江苏靶标生物医药研究所有限公司 一种调节哺乳动物的肠道粘膜稳态或炎症性肠病的靶点及其应用
WO2022262321A1 (zh) * 2021-06-17 2022-12-22 东莞市朋志生物科技有限公司 嵌合的免疫球蛋白
CN117903282A (zh) * 2016-12-22 2024-04-19 库尔生物制药有限公司 T细胞调节性多聚体多肽及其使用方法
US12091467B2 (en) 2016-10-20 2024-09-17 I-Mab Biopharma Us Limited CD47 monoclonal antibodies and uses thereof

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US7601351B1 (en) 2002-06-26 2009-10-13 Human Genome Sciences, Inc. Antibodies against protective antigen
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ATE555133T1 (de) 2003-11-13 2012-05-15 Hanmi Holdings Co Ltd Igg fc fragment für einen arzneimittelträger und verfahren zu dessen herstellung
US8110665B2 (en) 2003-11-13 2012-02-07 Hanmi Holdings Co., Ltd. Pharmaceutical composition comprising an immunoglobulin FC region as a carrier
BRPI0514259A (pt) * 2004-08-11 2008-06-03 Trubion Pharmaceuticals Inc proteìna de fusão de domìnio de ligação
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HRP20140338T1 (hr) * 2005-07-25 2014-06-20 Emergent Product Development Seattle, Llc Smanjenje broja b-stanica upotrebom molekula koje se specifiäśno vežu na cd37 i cd20
JP2009502936A (ja) 2005-07-25 2009-01-29 トルビオン ファーマシューティカルズ， インコーポレイテッド Ｃｄ２０特異的結合分子の単一投与量
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BRPI0710011A2 (pt) * 2006-04-14 2011-08-02 Trubion Pharmaceuticals Inc proteìnas de ligação compreendendo articulação de imunoglobulina e regiões fc dotadas de funções efetoras fc alteradas
BRPI0709623A2 (pt) * 2006-04-19 2011-07-19 Wyeth Corp polinucleotìdeo inibitório, molécula de dna isolado, célula hospedeira, microorganismo, animal transgênico não humano, planta transgênica, kit, e, método para regular de modo negativo a expressão de um transgene por uma célula hospedeira
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