DE69207603T2 - Zusammensetzung und verfahren zur behandlung von zystischer fibrose - Google Patents

Zusammensetzung und verfahren zur behandlung von zystischer fibrose

Info

Publication number
DE69207603T2
DE69207603T2 DE69207603T DE69207603T DE69207603T2 DE 69207603 T2 DE69207603 T2 DE 69207603T2 DE 69207603 T DE69207603 T DE 69207603T DE 69207603 T DE69207603 T DE 69207603T DE 69207603 T2 DE69207603 T2 DE 69207603T2
Authority
DE
Germany
Prior art keywords
macromolecule
fibrose
composition
treating cystic
cystic fibrosis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69207603T
Other languages
English (en)
Other versions
DE69207603D1 (de
Inventor
Philip Felgner
Anna Abai
Marston Manthorpe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fresh Tracks Therapeutics Inc
Original Assignee
Vical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vical Inc filed Critical Vical Inc
Publication of DE69207603D1 publication Critical patent/DE69207603D1/de
Application granted granted Critical
Publication of DE69207603T2 publication Critical patent/DE69207603T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4712—Cystic fibrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/21—Endodeoxyribonucleases producing 5'-phosphomonoesters (3.1.21)
    • C12Y301/21001—Deoxyribonuclease I (3.1.21.1)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
DE69207603T 1991-08-16 1992-05-19 Zusammensetzung und verfahren zur behandlung von zystischer fibrose Expired - Fee Related DE69207603T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74590091A 1991-08-16 1991-08-16
PCT/US1992/004225 WO1993003709A1 (en) 1991-08-16 1992-05-19 Composition and method for treating cystic fibrosis

Publications (2)

Publication Number Publication Date
DE69207603D1 DE69207603D1 (de) 1996-02-22
DE69207603T2 true DE69207603T2 (de) 1996-09-12

Family

ID=24998709

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69207603T Expired - Fee Related DE69207603T2 (de) 1991-08-16 1992-05-19 Zusammensetzung und verfahren zur behandlung von zystischer fibrose

Country Status (7)

Country Link
EP (1) EP0599850B1 (de)
JP (1) JPH06510036A (de)
AT (1) ATE132742T1 (de)
AU (1) AU2143992A (de)
CA (1) CA2115364A1 (de)
DE (1) DE69207603T2 (de)
WO (1) WO1993003709A1 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004045186B4 (de) * 2004-05-25 2011-08-18 Engelhard Lyon S.A. Liposomen, die die intrazelluläre Penetration von Wirkstofen stimulieren, deren Verwendung zur Herstellung von topischen pharmazeutischen bzw. kosmetischen Zusammensetzungen, die diese Liposomen enthalten sowie ein Screening-Verfahren zum Auffinden von Substanzen zur Stimulierung der intrazellulären Penetration

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US5792751A (en) * 1992-04-13 1998-08-11 Baylor College Of Medicine Tranformation of cells associated with fluid spaces
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US5863563A (en) * 1994-10-20 1999-01-26 Alphagene Inc. Treatment of pulmonary conditions associated with insufficient secretion of surfactant
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004045186B4 (de) * 2004-05-25 2011-08-18 Engelhard Lyon S.A. Liposomen, die die intrazelluläre Penetration von Wirkstofen stimulieren, deren Verwendung zur Herstellung von topischen pharmazeutischen bzw. kosmetischen Zusammensetzungen, die diese Liposomen enthalten sowie ein Screening-Verfahren zum Auffinden von Substanzen zur Stimulierung der intrazellulären Penetration
DE102004045186B9 (de) * 2004-05-25 2012-02-16 Engelhard Lyon S.A. Liposomen, die die intrazelluläre Penetration von Wirkstoffen stimulieren, deren Verwendung zur Herstellung von topischen pharmazeutischen bzw. kosmetischen Zusammensetzungen, die diese Liposomen enthalten sowie ein Screening-Verfahren zum Auffinden von Substanzen zur Stimulierung der intrazellulären Penetration

Also Published As

Publication number Publication date
EP0599850A1 (de) 1994-06-08
ATE132742T1 (de) 1996-01-15
JPH06510036A (ja) 1994-11-10
DE69207603D1 (de) 1996-02-22
WO1993003709A1 (en) 1993-03-04
AU2143992A (en) 1993-03-16
EP0599850B1 (de) 1996-01-10
CA2115364A1 (en) 1993-03-04

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