DE69129747D1 - In lösung bringen von proteinen in aktiver form - Google Patents
In lösung bringen von proteinen in aktiver formInfo
- Publication number
- DE69129747D1 DE69129747D1 DE69129747T DE69129747T DE69129747D1 DE 69129747 D1 DE69129747 D1 DE 69129747D1 DE 69129747 T DE69129747 T DE 69129747T DE 69129747 T DE69129747 T DE 69129747T DE 69129747 D1 DE69129747 D1 DE 69129747D1
- Authority
- DE
- Germany
- Prior art keywords
- active form
- solution
- protein
- refolding
- bringing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 4
- 108090000623 proteins and genes Proteins 0.000 title abstract 4
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Divinylene sulfide Natural products C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AUPK215990 | 1990-09-05 | ||
PCT/AU1991/000395 WO1992004382A1 (en) | 1990-09-05 | 1991-08-29 | Solubilization of proteins in active forms |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69129747D1 true DE69129747D1 (de) | 1998-08-13 |
DE69129747T2 DE69129747T2 (de) | 1998-11-12 |
Family
ID=3774938
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69129747T Expired - Fee Related DE69129747T2 (de) | 1990-09-05 | 1991-08-29 | In lösung bringen von proteinen in aktiver form |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0547102B1 (de) |
AT (1) | ATE168115T1 (de) |
AU (1) | AU664021B2 (de) |
CA (1) | CA2090701C (de) |
DE (1) | DE69129747T2 (de) |
DK (1) | DK0547102T3 (de) |
ES (1) | ES2119779T3 (de) |
WO (1) | WO1992004382A1 (de) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU4665193A (en) * | 1992-07-02 | 1994-01-31 | Pitman-Moore, Inc. | A process for recovering a recombinant protein, in biologically active form, from a solution containing inactive protein |
DK44593D0 (da) * | 1993-04-20 | 1993-04-20 | Novo Nordisk As | Fremgangsmaade til fremstilling af et polypeptid |
DE69432231T2 (de) * | 1993-09-22 | 2004-02-05 | Ajinomoto Co., Inc. | Peptide mit antithrombotischer aktivität und verfahren zu ihrer herstellung |
ZA955789B (en) * | 1994-07-15 | 1996-03-11 | Novo Nordisk As | A method of converting a hydrophobic derivative of a polypeptide into the native form |
DE10309691B4 (de) * | 2003-02-28 | 2018-10-04 | Hans-Knöll-Institut für Naturstoff-Forschung e.V. | Gewinnung von löslichen Proteinen aus der Biomasse rekombinanter Mikroorganismen |
JP5808323B2 (ja) | 2009-06-22 | 2015-11-10 | アムジエン・インコーポレーテツド | 化学的に制御されたレドックス状態を用いたタンパク質のリフォールディング |
CA2765154A1 (en) | 2009-06-25 | 2010-12-29 | Amgen Inc. | Capture purification processes for proteins expressed in a non-mammalian system |
EP3299378B1 (de) | 2013-02-12 | 2019-07-31 | Bristol-Myers Squibb Company | Rückfaltungsverfahren für protein mit hohem ph-wert |
WO2014126871A1 (en) | 2013-02-12 | 2014-08-21 | Bristol-Myers Squibb Company | Tangential flow filtration based protein refolding methods |
WO2014155349A2 (en) | 2013-03-29 | 2014-10-02 | Dr. Reddy's Laboratories | Refolding of proteins |
EP3344651B1 (de) | 2015-09-02 | 2022-03-02 | Merck Sharp & Dohme Corp. | Verfahren zur gewinnung von insulin mit korrekt geformten disulfidbindungen |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6079000A (ja) * | 1983-10-04 | 1985-05-04 | Takeda Chem Ind Ltd | ヒトγ型インタ−フエロン単量体の製造法 |
DE3587526T3 (de) * | 1984-12-06 | 2002-08-08 | Amgen Inc N D Ges D Staates De | Serinproteaseinhibitoren und isolierungsverfahren dazu. |
DE3537708A1 (de) * | 1985-10-23 | 1987-04-23 | Boehringer Mannheim Gmbh | Verfahren zur aktivierung von t-pa nach expression in prokaryonten |
US4766205A (en) * | 1985-11-13 | 1988-08-23 | Beatrice Companies, Inc. | Method for isolation of recombinant polypeptides in biologically active forms |
DE3611817A1 (de) * | 1986-04-08 | 1987-10-15 | Boehringer Mannheim Gmbh | Verfahren zur renaturierung von proteinen |
AU612133B2 (en) * | 1987-02-20 | 1991-07-04 | Natinco Nv | Production of proteins in active forms |
IL86090A (en) * | 1987-04-16 | 1993-03-15 | Cetus Oncology Corp | Production of purified, biologically active, bacterially produced recombinant human csf-1 |
EP0295859B1 (de) * | 1987-06-15 | 1994-11-17 | Southern Cross Biotech Pty.Ltd. | Herstellung von Proteinen in aktiver Form |
KR890701759A (ko) * | 1987-07-29 | 1989-12-21 | 스테이너 브이. 칸스태드 | 에스케리키아 콜라이내에서 발현된 사람 인터루킨-4의 정제방법 |
CA1340586C (en) * | 1988-09-23 | 1999-06-08 | Cetus Corporation | Process for recovering microbially produced interferon-beta |
DE3832898A1 (de) * | 1988-09-28 | 1990-04-12 | Boehringer Mannheim Gmbh | Praeparat von in prokaryonten exprimiertem plasminogenaktivator |
DE3901718A1 (de) * | 1989-01-21 | 1990-07-26 | Hoechst Ag | Verfahren zur renaturierung falscher rekombinanten von insulinvorlaeufern |
DE3901719A1 (de) * | 1989-01-21 | 1990-07-26 | Hoechst Ag | Verfahren zur herstellung eines insulinvorlaeufers |
GB8927546D0 (en) * | 1989-12-06 | 1990-02-07 | Ciba Geigy | Process for the production of biologically active tgf-beta |
US5235043A (en) * | 1990-04-06 | 1993-08-10 | Synergen, Inc. | Production of biologically active, recombinant members of the ngf/bdnf family of neurotrophic proteins |
DE4113750A1 (de) * | 1991-04-26 | 1992-10-29 | Boehringer Mannheim Gmbh | Verbesserung der renaturierung bei der sekretion von disulfidverbrueckten proteinen |
-
1991
- 1991-08-29 WO PCT/AU1991/000395 patent/WO1992004382A1/en active IP Right Grant
- 1991-08-29 CA CA002090701A patent/CA2090701C/en not_active Expired - Fee Related
- 1991-08-29 AT AT91915661T patent/ATE168115T1/de not_active IP Right Cessation
- 1991-08-29 ES ES91915661T patent/ES2119779T3/es not_active Expired - Lifetime
- 1991-08-29 EP EP91915661A patent/EP0547102B1/de not_active Expired - Lifetime
- 1991-08-29 AU AU84035/91A patent/AU664021B2/en not_active Ceased
- 1991-08-29 DK DK91915661T patent/DK0547102T3/da active
- 1991-08-29 DE DE69129747T patent/DE69129747T2/de not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO1992004382A1 (en) | 1992-03-19 |
DK0547102T3 (da) | 1999-04-19 |
EP0547102A1 (de) | 1993-06-23 |
DE69129747T2 (de) | 1998-11-12 |
ATE168115T1 (de) | 1998-07-15 |
AU664021B2 (en) | 1995-11-02 |
EP0547102B1 (de) | 1998-07-08 |
EP0547102A4 (de) | 1994-04-27 |
CA2090701A1 (en) | 1992-03-10 |
AU8403591A (en) | 1992-03-30 |
CA2090701C (en) | 2000-05-16 |
ES2119779T3 (es) | 1998-10-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: NANTINCO, NV, WILLENSTED, CURACAO, AN |
|
8339 | Ceased/non-payment of the annual fee |