ZA955789B - A method of converting a hydrophobic derivative of a polypeptide into the native form - Google Patents

A method of converting a hydrophobic derivative of a polypeptide into the native form

Info

Publication number
ZA955789B
ZA955789B ZA955789A ZA955789A ZA955789B ZA 955789 B ZA955789 B ZA 955789B ZA 955789 A ZA955789 A ZA 955789A ZA 955789 A ZA955789 A ZA 955789A ZA 955789 B ZA955789 B ZA 955789B
Authority
ZA
South Africa
Prior art keywords
polypeptide
converting
native form
hydrophobic derivative
hydrophobic
Prior art date
Application number
ZA955789A
Inventor
Thorkild Christensen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of ZA955789B publication Critical patent/ZA955789B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
ZA955789A 1994-07-15 1995-07-12 A method of converting a hydrophobic derivative of a polypeptide into the native form ZA955789B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK85094 1994-07-15

Publications (1)

Publication Number Publication Date
ZA955789B true ZA955789B (en) 1996-03-11

Family

ID=8098254

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA955789A ZA955789B (en) 1994-07-15 1995-07-12 A method of converting a hydrophobic derivative of a polypeptide into the native form

Country Status (4)

Country Link
AU (1) AU2922095A (en)
IL (1) IL114597A0 (en)
WO (1) WO1996002570A1 (en)
ZA (1) ZA955789B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9802454D0 (en) 1998-07-08 1998-07-08 Pharmacia & Upjohn Ab Production of peptides
ZA200501841B (en) * 2002-08-28 2007-06-27 Pharmacia Corp Method for the preparation of growth hormone and antagonist thereof having lower levels of isoform impurities thereof
US20040048315A1 (en) * 2002-08-28 2004-03-11 Pharmacia Corporation Method for the preparation of growth hormone and antagonist thereof having lower levels of isoform impurities thereof
US7470779B2 (en) 2002-09-20 2008-12-30 Pfizer Inc. Process for decreasing aggregate levels of pegylated protein
PL212726B1 (en) * 2002-09-20 2012-11-30 Pharmacia Corp Process for decreasing aggregate levels of pegylated protein
US20090131311A1 (en) * 2004-12-29 2009-05-21 Novo Nordisk Healthcare Ag Method for Preventing Formation of Trisulfide Derivatives of Polypeptides
WO2011041721A1 (en) 2009-10-02 2011-04-07 Biogen Idec Ma Inc. Methods of preventing and removing trisulfide bonds
WO2012158551A1 (en) 2011-05-13 2012-11-22 Biogen Idec Ma Inc. Methods of preventing and removing trisulfide bonds
RU2744978C2 (en) 2014-07-24 2021-03-17 Дженентек, Инк. Methods for conjugation of agent with thiol group in protein comprising at least one trisulfide bond

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4923967A (en) * 1988-09-26 1990-05-08 Eli Lilly And Company Purification and refolding of recombinant proteins
DE69129747T2 (en) * 1990-09-05 1998-11-12 Southern Cross Biotech Pty Ltd BRINGING PROTEINS IN SOLUTION IN ACTIVE FORM

Also Published As

Publication number Publication date
AU2922095A (en) 1996-02-16
WO1996002570A1 (en) 1996-02-01
IL114597A0 (en) 1995-11-27

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