ATE168115T1 - In lösung bringen von proteinen in aktiver form - Google Patents
In lösung bringen von proteinen in aktiver formInfo
- Publication number
- ATE168115T1 ATE168115T1 AT91915661T AT91915661T ATE168115T1 AT E168115 T1 ATE168115 T1 AT E168115T1 AT 91915661 T AT91915661 T AT 91915661T AT 91915661 T AT91915661 T AT 91915661T AT E168115 T1 ATE168115 T1 AT E168115T1
- Authority
- AT
- Austria
- Prior art keywords
- active form
- protein
- refolding
- dissolving proteins
- solubilised
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 4
- 108090000623 proteins and genes Proteins 0.000 title abstract 4
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Divinylene sulfide Natural products C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AUPK215990 | 1990-09-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE168115T1 true ATE168115T1 (de) | 1998-07-15 |
Family
ID=3774938
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT91915661T ATE168115T1 (de) | 1990-09-05 | 1991-08-29 | In lösung bringen von proteinen in aktiver form |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0547102B1 (de) |
AT (1) | ATE168115T1 (de) |
AU (1) | AU664021B2 (de) |
CA (1) | CA2090701C (de) |
DE (1) | DE69129747T2 (de) |
DK (1) | DK0547102T3 (de) |
ES (1) | ES2119779T3 (de) |
WO (1) | WO1992004382A1 (de) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL306858A1 (en) * | 1992-07-02 | 1995-04-18 | Pitman Moore Inc | Method of isolating recombination protein in biologically active form from a solution containing non-active protein |
DK44593D0 (da) * | 1993-04-20 | 1993-04-20 | Novo Nordisk As | Fremgangsmaade til fremstilling af et polypeptid |
KR960704934A (ko) * | 1993-09-22 | 1996-10-09 | 이나모리 준스케 | 항혈전활성을 갖는 펩티드 및 이의 제조방법(Peptide having antithrombotic activity and process for producing the same) |
ZA955789B (en) * | 1994-07-15 | 1996-03-11 | Novo Nordisk As | A method of converting a hydrophobic derivative of a polypeptide into the native form |
DE10309691B4 (de) * | 2003-02-28 | 2018-10-04 | Hans-Knöll-Institut für Naturstoff-Forschung e.V. | Gewinnung von löslichen Proteinen aus der Biomasse rekombinanter Mikroorganismen |
EP3366692A1 (de) * | 2009-06-22 | 2018-08-29 | Amgen, Inc | Proteinneufaltung mit einem chemisch gesteuerten redoxzustand |
MX2011013417A (es) | 2009-06-25 | 2012-03-29 | Amgen Inc | Procesos de purificacion por captura para proteinas expresadas en un sistema no mamifero. |
WO2014126871A1 (en) | 2013-02-12 | 2014-08-21 | Bristol-Myers Squibb Company | Tangential flow filtration based protein refolding methods |
WO2014126884A1 (en) | 2013-02-12 | 2014-08-21 | Bristol-Myers Squibb Company | High ph protein refolding methods |
US9982012B2 (en) | 2013-03-29 | 2018-05-29 | Dr. Reddy's Laboratories Limited | Refolding of granulocyte colony stimulating factor |
EP3344651B1 (de) | 2015-09-02 | 2022-03-02 | Merck Sharp & Dohme Corp. | Verfahren zur gewinnung von insulin mit korrekt geformten disulfidbindungen |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6079000A (ja) * | 1983-10-04 | 1985-05-04 | Takeda Chem Ind Ltd | ヒトγ型インタ−フエロン単量体の製造法 |
WO1986003497A1 (en) * | 1984-12-06 | 1986-06-19 | Synergen Biologicals, Inc. | Serine protease inhibitors and methods for isolation of same |
DE3537708A1 (de) * | 1985-10-23 | 1987-04-23 | Boehringer Mannheim Gmbh | Verfahren zur aktivierung von t-pa nach expression in prokaryonten |
US4766205A (en) * | 1985-11-13 | 1988-08-23 | Beatrice Companies, Inc. | Method for isolation of recombinant polypeptides in biologically active forms |
DE3611817A1 (de) * | 1986-04-08 | 1987-10-15 | Boehringer Mannheim Gmbh | Verfahren zur renaturierung von proteinen |
AU612133B2 (en) * | 1987-02-20 | 1991-07-04 | Natinco Nv | Production of proteins in active forms |
IL86090A (en) * | 1987-04-16 | 1993-03-15 | Cetus Oncology Corp | Production of purified, biologically active, bacterially produced recombinant human csf-1 |
EP0295859B1 (de) * | 1987-06-15 | 1994-11-17 | Southern Cross Biotech Pty.Ltd. | Herstellung von Proteinen in aktiver Form |
EP0301835A1 (de) * | 1987-07-29 | 1989-02-01 | Schering Biotech Corporation | Reinigung von in Escherichia coli exprimiertem, menschlichem Interleukin-4 |
CA1340586C (en) * | 1988-09-23 | 1999-06-08 | Cetus Corporation | Process for recovering microbially produced interferon-beta |
DE3832898A1 (de) * | 1988-09-28 | 1990-04-12 | Boehringer Mannheim Gmbh | Praeparat von in prokaryonten exprimiertem plasminogenaktivator |
DE3901718A1 (de) * | 1989-01-21 | 1990-07-26 | Hoechst Ag | Verfahren zur renaturierung falscher rekombinanten von insulinvorlaeufern |
DE3901719A1 (de) * | 1989-01-21 | 1990-07-26 | Hoechst Ag | Verfahren zur herstellung eines insulinvorlaeufers |
GB8927546D0 (en) * | 1989-12-06 | 1990-02-07 | Ciba Geigy | Process for the production of biologically active tgf-beta |
US5235043A (en) * | 1990-04-06 | 1993-08-10 | Synergen, Inc. | Production of biologically active, recombinant members of the ngf/bdnf family of neurotrophic proteins |
DE4113750A1 (de) * | 1991-04-26 | 1992-10-29 | Boehringer Mannheim Gmbh | Verbesserung der renaturierung bei der sekretion von disulfidverbrueckten proteinen |
-
1991
- 1991-08-29 DE DE69129747T patent/DE69129747T2/de not_active Expired - Fee Related
- 1991-08-29 DK DK91915661T patent/DK0547102T3/da active
- 1991-08-29 EP EP91915661A patent/EP0547102B1/de not_active Expired - Lifetime
- 1991-08-29 CA CA002090701A patent/CA2090701C/en not_active Expired - Fee Related
- 1991-08-29 AU AU84035/91A patent/AU664021B2/en not_active Ceased
- 1991-08-29 WO PCT/AU1991/000395 patent/WO1992004382A1/en active IP Right Grant
- 1991-08-29 AT AT91915661T patent/ATE168115T1/de not_active IP Right Cessation
- 1991-08-29 ES ES91915661T patent/ES2119779T3/es not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CA2090701C (en) | 2000-05-16 |
DE69129747D1 (de) | 1998-08-13 |
WO1992004382A1 (en) | 1992-03-19 |
ES2119779T3 (es) | 1998-10-16 |
EP0547102B1 (de) | 1998-07-08 |
AU8403591A (en) | 1992-03-30 |
EP0547102A1 (de) | 1993-06-23 |
EP0547102A4 (de) | 1994-04-27 |
CA2090701A1 (en) | 1992-03-10 |
AU664021B2 (en) | 1995-11-02 |
DE69129747T2 (de) | 1998-11-12 |
DK0547102T3 (da) | 1999-04-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
EEIH | Change in the person of patent owner | ||
REN | Ceased due to non-payment of the annual fee |