ATE168115T1 - In lösung bringen von proteinen in aktiver form - Google Patents

In lösung bringen von proteinen in aktiver form

Info

Publication number
ATE168115T1
ATE168115T1 AT91915661T AT91915661T ATE168115T1 AT E168115 T1 ATE168115 T1 AT E168115T1 AT 91915661 T AT91915661 T AT 91915661T AT 91915661 T AT91915661 T AT 91915661T AT E168115 T1 ATE168115 T1 AT E168115T1
Authority
AT
Austria
Prior art keywords
active form
protein
refolding
dissolving proteins
solubilised
Prior art date
Application number
AT91915661T
Other languages
English (en)
Inventor
Nirdosh Kumar Puri
Enzo Crivelli
Original Assignee
Southern Cross Biotech Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Southern Cross Biotech Pty Ltd filed Critical Southern Cross Biotech Pty Ltd
Application granted granted Critical
Publication of ATE168115T1 publication Critical patent/ATE168115T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT91915661T 1990-09-05 1991-08-29 In lösung bringen von proteinen in aktiver form ATE168115T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AUPK215990 1990-09-05

Publications (1)

Publication Number Publication Date
ATE168115T1 true ATE168115T1 (de) 1998-07-15

Family

ID=3774938

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91915661T ATE168115T1 (de) 1990-09-05 1991-08-29 In lösung bringen von proteinen in aktiver form

Country Status (8)

Country Link
EP (1) EP0547102B1 (de)
AT (1) ATE168115T1 (de)
AU (1) AU664021B2 (de)
CA (1) CA2090701C (de)
DE (1) DE69129747T2 (de)
DK (1) DK0547102T3 (de)
ES (1) ES2119779T3 (de)
WO (1) WO1992004382A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0650497A1 (de) * 1992-07-02 1995-05-03 Mallinckrodt Veterinary, Inc. Verfahren zur ruckgewinnung von eine biologisch aktiven form eines rekombinantes protein, aus einer unaktive protein enthaltenden losung
DK44593D0 (da) * 1993-04-20 1993-04-20 Novo Nordisk As Fremgangsmaade til fremstilling af et polypeptid
WO1995008573A1 (en) * 1993-09-22 1995-03-30 Ajinomoto Co., Inc. Peptide having antithrombotic activity and process for producing the same
ZA955789B (en) * 1994-07-15 1996-03-11 Novo Nordisk As A method of converting a hydrophobic derivative of a polypeptide into the native form
DE10309691B4 (de) * 2003-02-28 2018-10-04 Hans-Knöll-Institut für Naturstoff-Forschung e.V. Gewinnung von löslichen Proteinen aus der Biomasse rekombinanter Mikroorganismen
CN102482321B (zh) 2009-06-22 2015-06-17 安姆根有限公司 使用化学控制的氧化还原态重折叠蛋白质
WO2010151688A2 (en) 2009-06-25 2010-12-29 Amgen Inc. Capture purification processes for proteins expressed in a non-mammalian system
EP3299378B1 (de) 2013-02-12 2019-07-31 Bristol-Myers Squibb Company Rückfaltungsverfahren für protein mit hohem ph-wert
US10183967B2 (en) 2013-02-12 2019-01-22 Bristol-Myers Squibb Company Tangential flow filtration based protein refolding methods
US9982012B2 (en) 2013-03-29 2018-05-29 Dr. Reddy's Laboratories Limited Refolding of granulocyte colony stimulating factor
EP3344651B1 (de) 2015-09-02 2022-03-02 Merck Sharp & Dohme Corp. Verfahren zur gewinnung von insulin mit korrekt geformten disulfidbindungen

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6079000A (ja) * 1983-10-04 1985-05-04 Takeda Chem Ind Ltd ヒトγ型インタ−フエロン単量体の製造法
EP0205555B2 (de) * 1984-12-06 2002-04-10 Amgen Inc. Serinproteaseinhibitoren und isolierungsverfahren dazu
DE3537708A1 (de) * 1985-10-23 1987-04-23 Boehringer Mannheim Gmbh Verfahren zur aktivierung von t-pa nach expression in prokaryonten
US4766205A (en) * 1985-11-13 1988-08-23 Beatrice Companies, Inc. Method for isolation of recombinant polypeptides in biologically active forms
DE3611817A1 (de) * 1986-04-08 1987-10-15 Boehringer Mannheim Gmbh Verfahren zur renaturierung von proteinen
AU612133B2 (en) * 1987-02-20 1991-07-04 Natinco Nv Production of proteins in active forms
IL86090A (en) * 1987-04-16 1993-03-15 Cetus Oncology Corp Production of purified, biologically active, bacterially produced recombinant human csf-1
EP0295859B1 (de) * 1987-06-15 1994-11-17 Southern Cross Biotech Pty.Ltd. Herstellung von Proteinen in aktiver Form
WO1989001046A1 (en) * 1987-07-29 1989-02-09 Schering Biotech Corporation Purification of human interleukin-4 expressed in escherichia coli
CA1340586C (en) * 1988-09-23 1999-06-08 Cetus Corporation Process for recovering microbially produced interferon-beta
DE3832898A1 (de) * 1988-09-28 1990-04-12 Boehringer Mannheim Gmbh Praeparat von in prokaryonten exprimiertem plasminogenaktivator
DE3901718A1 (de) * 1989-01-21 1990-07-26 Hoechst Ag Verfahren zur renaturierung falscher rekombinanten von insulinvorlaeufern
DE3901719A1 (de) * 1989-01-21 1990-07-26 Hoechst Ag Verfahren zur herstellung eines insulinvorlaeufers
GB8927546D0 (en) * 1989-12-06 1990-02-07 Ciba Geigy Process for the production of biologically active tgf-beta
US5235043A (en) * 1990-04-06 1993-08-10 Synergen, Inc. Production of biologically active, recombinant members of the ngf/bdnf family of neurotrophic proteins
DE4113750A1 (de) * 1991-04-26 1992-10-29 Boehringer Mannheim Gmbh Verbesserung der renaturierung bei der sekretion von disulfidverbrueckten proteinen

Also Published As

Publication number Publication date
CA2090701C (en) 2000-05-16
EP0547102A1 (de) 1993-06-23
EP0547102A4 (de) 1994-04-27
EP0547102B1 (de) 1998-07-08
CA2090701A1 (en) 1992-03-10
AU664021B2 (en) 1995-11-02
DK0547102T3 (da) 1999-04-19
AU8403591A (en) 1992-03-30
WO1992004382A1 (en) 1992-03-19
DE69129747D1 (de) 1998-08-13
ES2119779T3 (es) 1998-10-16
DE69129747T2 (de) 1998-11-12

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner
REN Ceased due to non-payment of the annual fee