BR9004693A - Solucao aquosa,processo para aumentar a concentracao de proteina de uma proteina em uma solucao aquosa,e composicao farmaceutica - Google Patents

Solucao aquosa,processo para aumentar a concentracao de proteina de uma proteina em uma solucao aquosa,e composicao farmaceutica

Info

Publication number
BR9004693A
BR9004693A BR909004693A BR9004693A BR9004693A BR 9004693 A BR9004693 A BR 9004693A BR 909004693 A BR909004693 A BR 909004693A BR 9004693 A BR9004693 A BR 9004693A BR 9004693 A BR9004693 A BR 9004693A
Authority
BR
Brazil
Prior art keywords
protein
aqueous solution
increase
pharmaceutical composition
protein concentration
Prior art date
Application number
BR909004693A
Other languages
English (en)
Inventor
Yukio Shimazaki
Nobuhiro Kawashima
Miki Yohioka
Yasuhito Tanaka
Ryo Tanaka
Kiyoshi Sakai
Hisahiro Ishiwari
Original Assignee
Mitsui Toatsu Chemicals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Toatsu Chemicals filed Critical Mitsui Toatsu Chemicals
Publication of BR9004693A publication Critical patent/BR9004693A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/49—Urokinase; Tissue plasminogen activator
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Jellies, Jams, And Syrups (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
BR909004693A 1989-09-21 1990-09-20 Solucao aquosa,processo para aumentar a concentracao de proteina de uma proteina em uma solucao aquosa,e composicao farmaceutica BR9004693A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1243311A JPH0791318B2 (ja) 1989-09-21 1989-09-21 蛋白質水溶液、蛋白質水溶液の濃度増大方法および蛋白質製剤

Publications (1)

Publication Number Publication Date
BR9004693A true BR9004693A (pt) 1991-09-10

Family

ID=17101947

Family Applications (1)

Application Number Title Priority Date Filing Date
BR909004693A BR9004693A (pt) 1989-09-21 1990-09-20 Solucao aquosa,processo para aumentar a concentracao de proteina de uma proteina em uma solucao aquosa,e composicao farmaceutica

Country Status (14)

Country Link
EP (1) EP0419251B1 (pt)
JP (1) JPH0791318B2 (pt)
KR (1) KR930004598B1 (pt)
CN (1) CN1049356C (pt)
AT (1) ATE93731T1 (pt)
AU (1) AU627621B2 (pt)
BR (1) BR9004693A (pt)
CA (1) CA2025315C (pt)
DE (1) DE69003061T2 (pt)
DK (1) DK0419251T3 (pt)
ES (1) ES2060057T3 (pt)
FI (1) FI98891C (pt)
NO (1) NO904120L (pt)
NZ (1) NZ235297A (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996040784A2 (en) * 1995-06-07 1996-12-19 Chiron Corporation Method of solubilizing, purifying, and refolding protein
US20040033228A1 (en) 2002-08-16 2004-02-19 Hans-Juergen Krause Formulation of human antibodies for treating TNF-alpha associated disorders
MY150740A (en) 2002-10-24 2014-02-28 Abbvie Biotechnology Ltd Low dose methods for treating disorders in which tnf? activity is detrimental
CN101679507A (zh) 2007-03-29 2010-03-24 艾博特公司 结晶抗人类il-12抗体
US8883146B2 (en) 2007-11-30 2014-11-11 Abbvie Inc. Protein formulations and methods of making same

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2107185A (en) * 1981-10-07 1983-04-27 John Kenneth Mcmullen Insulin formulations containing surface-active agents
DE3584902D1 (de) * 1984-02-29 1992-01-30 Asahi Chemical Ind Waessrige loesung eines darin in erhoehter konzentration aufgeloesten gewebe-plasminogen-aktivators und herstellungsverfahren.
DE3512908A1 (de) * 1985-04-11 1986-10-23 Behringwerke Ag, 3550 Marburg Gewebe-plasminogenaktivator (t-pa) enthaltendes mittel
JPS61289886A (ja) * 1985-06-19 1986-12-19 Agency Of Ind Science & Technol 酵素及び／又は微生物含有アルギン酸繊維紙の製造法
CA1292686C (en) * 1986-10-27 1991-12-03 Ze'ev Shaked Pharmaceutical compositions of recombinant interleukin-2 and formulation process
US4857320A (en) * 1987-02-19 1989-08-15 Monsanto Company Method of enhancing the solubility of tissue plasminogen activator
JPH02111726A (ja) * 1988-10-19 1990-04-24 Dainippon Pharmaceut Co Ltd ヒト　インターロイキン１を安定化する方法

Also Published As

Publication number Publication date
ES2060057T3 (es) 1994-11-16
NZ235297A (en) 1992-12-23
DE69003061D1 (de) 1993-10-07
AU6246690A (en) 1991-03-28
FI98891C (fi) 1997-09-10
NO904120L (no) 1991-03-22
EP0419251B1 (en) 1993-09-01
CN1049356C (zh) 2000-02-16
FI904618A0 (fi) 1990-09-19
ATE93731T1 (de) 1993-09-15
DE69003061T2 (de) 1993-12-16
AU627621B2 (en) 1992-08-27
NO904120D0 (no) 1990-09-20
JPH03106898A (ja) 1991-05-07
EP0419251A1 (en) 1991-03-27
KR930004598B1 (ko) 1993-06-01
CA2025315C (en) 1997-01-07
CA2025315A1 (en) 1991-03-22
FI98891B (fi) 1997-05-30
CN1050327A (zh) 1991-04-03
KR910005884A (ko) 1991-04-27
DK0419251T3 (da) 1994-01-31
JPH0791318B2 (ja) 1995-10-04

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Legal Events

Date Code Title Description
FC Decision: refusal