KR910005884A - 단백질 수용액 - Google Patents

단백질 수용액 Download PDF

Info

Publication number
KR910005884A
KR910005884A KR1019900015032A KR900015032A KR910005884A KR 910005884 A KR910005884 A KR 910005884A KR 1019900015032 A KR1019900015032 A KR 1019900015032A KR 900015032 A KR900015032 A KR 900015032A KR 910005884 A KR910005884 A KR 910005884A
Authority
KR
South Korea
Prior art keywords
protein
aqueous solution
anionic polymer
salt
isoelectric point
Prior art date
Application number
KR1019900015032A
Other languages
English (en)
Other versions
KR930004598B1 (ko
Inventor
유끼오 시마자끼
노부히로 가와시마
야스히또 다나까
죠 다나까
기요시 사까이
히사히로 이시와라
Original Assignee
원본미기재
미쯔이도오아쓰 가가꾸 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 원본미기재, 미쯔이도오아쓰 가가꾸 가부시끼가이샤 filed Critical 원본미기재
Publication of KR910005884A publication Critical patent/KR910005884A/ko
Application granted granted Critical
Publication of KR930004598B1 publication Critical patent/KR930004598B1/ko

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/49—Urokinase; Tissue plasminogen activator
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Jellies, Jams, And Syrups (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

내용 없음

Description

단백질 수용액
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (14)

  1. 단백질 및 음이온성 중합체 또는 그의 염을 함유하는 수용액.
  2. 제1항에 있어서, 음이온성 중합체 또는 그의 염이 단백질에 대해 1:40이상의 중량비로 존재하는 수용액.
  3. 제1항에 있어서, 단백질의 등전점 -2~+2pH단위의 pH를 갖는 수용액.
  4. 제1항에 있어서, 0.05몰/ℓ이하의 이온강도를 갖는 수용액.
  5. 제1항에 있어서, 음이온성 중합체 또는 그의 염이외의 염 함량이 단백질 1mg당 0.1몰 이하인 수용액.
  6. 제1항에 있어서, 음이온성 중합체가 카르복실기, 카르복시메틸기, 황산기 및 인산기로 이루어진 군에서 선택된 적어도 하나의 음이온 잔기를 갖는 수용액.
  7. 단백질 수용액에서 음이온성 중합체 또는 그의 염을 첨가함을 특징으로 하는, 수용액중의 단백질 농도의 증대 방법.
  8. 음이온성 중합체 또는 그의 염 및 단백질을 함유하는 약학 조성물.
  9. 제1항 내지 6항중 어느 한 항에 있어서, 단백질이 생리 활성 단백질인 수용액.
  10. 제7항에 있어서, 단백질이 생리 활성 단백질인 수용액중의 단백질 농도의 증대방법.
  11. 제8항에 있어서, 단백질이 생리활성 단백질인 조성물.
  12. 제1항 내지 6항중 어느 한 항에 있어서, 단백질의 등전점이 pH 4이상인 수용액.
  13. 제7항에 있어서, 단백질의 등전점이 pH 1이상인, 수용액중의 단백질 농도의 증대방법.
  14. 제8항에 있어서, 단백질의 등전점이 pH 4이상인 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900015032A 1989-09-21 1990-09-21 단백질 수용액 KR930004598B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP1243311A JPH0791318B2 (ja) 1989-09-21 1989-09-21 蛋白質水溶液、蛋白質水溶液の濃度増大方法および蛋白質製剤
JP1-243311 1989-09-21
JP243311 1989-09-21

Publications (2)

Publication Number Publication Date
KR910005884A true KR910005884A (ko) 1991-04-27
KR930004598B1 KR930004598B1 (ko) 1993-06-01

Family

ID=17101947

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019900015032A KR930004598B1 (ko) 1989-09-21 1990-09-21 단백질 수용액

Country Status (14)

Country Link
EP (1) EP0419251B1 (ko)
JP (1) JPH0791318B2 (ko)
KR (1) KR930004598B1 (ko)
CN (1) CN1049356C (ko)
AT (1) ATE93731T1 (ko)
AU (1) AU627621B2 (ko)
BR (1) BR9004693A (ko)
CA (1) CA2025315C (ko)
DE (1) DE69003061T2 (ko)
DK (1) DK0419251T3 (ko)
ES (1) ES2060057T3 (ko)
FI (1) FI98891C (ko)
NO (1) NO904120L (ko)
NZ (1) NZ235297A (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69635051T2 (de) * 1995-06-07 2006-06-14 Chiron Corp Methode zur lösung, reinigung und rückfaltung von protein
US20040033228A1 (en) 2002-08-16 2004-02-19 Hans-Juergen Krause Formulation of human antibodies for treating TNF-alpha associated disorders
MY150740A (en) 2002-10-24 2014-02-28 Abbvie Biotechnology Ltd Low dose methods for treating disorders in which tnf? activity is detrimental
MX2009010361A (es) 2007-03-29 2009-10-16 Abbott Lab Anticuerpos il-12 anti-humanos cristalinos.
US8883146B2 (en) 2007-11-30 2014-11-11 Abbvie Inc. Protein formulations and methods of making same

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2107185A (en) * 1981-10-07 1983-04-27 John Kenneth Mcmullen Insulin formulations containing surface-active agents
EP0156169B1 (en) * 1984-02-29 1991-12-18 Asahi Kasei Kogyo Kabushiki Kaisha An aqueous solution of a tissue plasminogen activator dissolved therein at an increased concentration and a method
DE3512908A1 (de) * 1985-04-11 1986-10-23 Behringwerke Ag, 3550 Marburg Gewebe-plasminogenaktivator (t-pa) enthaltendes mittel
JPS61289886A (ja) * 1985-06-19 1986-12-19 Agency Of Ind Science & Technol 酵素及び／又は微生物含有アルギン酸繊維紙の製造法
CA1292686C (en) * 1986-10-27 1991-12-03 Ze'ev Shaked Pharmaceutical compositions of recombinant interleukin-2 and formulation process
US4857320A (en) * 1987-02-19 1989-08-15 Monsanto Company Method of enhancing the solubility of tissue plasminogen activator
JPH02111726A (ja) * 1988-10-19 1990-04-24 Dainippon Pharmaceut Co Ltd ヒト　インターロイキン１を安定化する方法

Also Published As

Publication number Publication date
ATE93731T1 (de) 1993-09-15
EP0419251B1 (en) 1993-09-01
BR9004693A (pt) 1991-09-10
FI98891B (fi) 1997-05-30
CN1050327A (zh) 1991-04-03
CN1049356C (zh) 2000-02-16
JPH03106898A (ja) 1991-05-07
AU6246690A (en) 1991-03-28
NO904120L (no) 1991-03-22
EP0419251A1 (en) 1991-03-27
CA2025315A1 (en) 1991-03-22
NO904120D0 (no) 1990-09-20
NZ235297A (en) 1992-12-23
FI98891C (fi) 1997-09-10
ES2060057T3 (es) 1994-11-16
AU627621B2 (en) 1992-08-27
DK0419251T3 (da) 1994-01-31
DE69003061D1 (de) 1993-10-07
KR930004598B1 (ko) 1993-06-01
DE69003061T2 (de) 1993-12-16
JPH0791318B2 (ja) 1995-10-04
FI904618A0 (fi) 1990-09-19
CA2025315C (en) 1997-01-07

Similar Documents

Publication Publication Date Title
KR850700216A (ko) 활성성분을 용해시키기 위한 방법 및 이로부터 얻어진 제약 조성물
BR9714434A (pt) Formulações de interferon liquidas estáveis
DE191133T1 (de) Stabile salze von sam mit polyanionen.
EP1281722A4 (en) HYALURONIC ACID GEL, METHOD FOR THE PRODUCTION THEREOF, AND THE MEDICAL MATERIAL CONTAINING GEL
KR970706017A (ko) 안정한 알파 인터페론 수용액 제형(Stable, aqueous alfainterfer on solution for mulations)
PT84663B (pt) Processo para a preparacao de novas composicoes farmaceuticas de accao prolongada contendo compostos activos praticamente insoluveis, especialmente dihidropiridinas substituidas
RU2001130142A (ru) Фармацевтические композиции эритропоэтина
BR0010665A (pt) ComposiçÈes farmacêuticas de eritropoietina
BR9812835A (pt) Composição de gel para barbear não-aerossol
ES2029853T5 (es) Base de unguento y unguento.
BR9905832A (pt) Formulações de clorohexidina, sais de clorohexidina, soluções contendo estes sais e seu uso
TR199800608A2 (en) Propanolamin t�revleri, bunlar�n �retim usul�.
KR880013572A (ko) 인슐린 및 인슐린 유도체의 혼합결정체, 이의 제조방법, 이를 함유하는 약제 및 이의 용도
RU97113465A (ru) Инъекционные или инфузионные растворы энрофлоксацина
KR910005884A (ko) 단백질 수용액
JPS5668607A (en) Medical preparation with storage stability
DE69315388T2 (de) Aus bakteriellen Proteinen bestehender Extrakt, Verfahren zur dessen Herstellung und diesen Extrakt enthaltende pharmazeutische Zusammensetzung
DE3863859D1 (de) Stabile, injizierbare loesungen von salzen von vincristin.
ATE59554T1 (de) Auf mercaptoethansulfonsaeuren basierende pharmazeutische zusammensetzungen, organische abkoemmlinge von mercaptoethansulfonsaeuren sowie verfahren zu deren herstellung.
ATE233562T1 (de) Verwendung von hyaluronsäure zur herstellung einer wässrigen lösung verwendbar als intra- artikulare reinigungslösung
DK0419252T3 (da) Trombolytisk sammensætning indeholdende vævstypeplasmonogenaktivator eller et derivat heraf
KR930012023A (ko) 환원된 형태의 비글리코실화 재조합 인체 il2의 안정화된 제약 조성물 및 그의 제조방법
ATE149354T1 (de) Pharmazeutische zusammensetzung von stabilisiertem (leu 13>-motilin-hse
KR910000154A (ko) 안정화된 피록시캄 주사액조성물과 그 제조방법
KR860003011A (ko) (-)시스-1,2-에폭시프로필포스폰산과 아미노산과의 염을 함유하는 수용성 제약 조성물

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
G160 Decision to publish patent application
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20020521

Year of fee payment: 10

LAPS Lapse due to unpaid annual fee