KR860003011A - (-)시스-1,2-에폭시프로필포스폰산과 아미노산과의 염을 함유하는 수용성 제약 조성물 - Google Patents

(-)시스-1,2-에폭시프로필포스폰산과 아미노산과의 염을 함유하는 수용성 제약 조성물 Download PDF

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Publication number
KR860003011A
KR860003011A KR1019850007327A KR850007327A KR860003011A KR 860003011 A KR860003011 A KR 860003011A KR 1019850007327 A KR1019850007327 A KR 1019850007327A KR 850007327 A KR850007327 A KR 850007327A KR 860003011 A KR860003011 A KR 860003011A
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KR
South Korea
Prior art keywords
salt
cis
acid
water
epoxypropylphosphonic
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KR1019850007327A
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English (en)
Inventor
메올라 스테파니아
Original Assignee
스간지니 카를로
세우레프 에이. 지.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 스간지니 카를로, 세우레프 에이. 지. filed Critical 스간지니 카를로
Publication of KR860003011A publication Critical patent/KR860003011A/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65502—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a three-membered ring
    • C07F9/65505—Phosphonic acids containing oxirane groups; esters thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

내용 없음

Description

(-)시스-1,2-에폭시프로필포스폰산과 아미노산과의 염을 함유하는 수용성 제약 조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. 시스-1,2-에폭시프로필포스폰산과 아미노산과의 염을 아미노알코올과 약 0.4 내지 약 0.8의 몰비로 수용액 또는 수성알코올용액중에서 반응시킴을 특징으로 하는, 유효 성분으로서 상기 염을 함유하는 수용성 제약 조성물의 제조방법.
  2. 제1항에 있어서, 아미노알코올을 1,1-디메틸-2-아미노에탄올, 2-아미노부탄올, 2-아미노-2-히드록시메틸-1,3-프로판디올로되는 군중에서 선택하는 방법.
  3. 제1항 또는 2항에 있어서, 유효성분이 시스-1,2-에폭시프로필포스폰산(포스포마이신)의 아르기닌염인 방법.
  4. 제1-3항 중 어느한 항에 있어서, 포스포마이신염/아미노 알코올의 몰비가 약 0.6인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850007327A 1984-10-05 1985-10-05 (-)시스-1,2-에폭시프로필포스폰산과 아미노산과의 염을 함유하는 수용성 제약 조성물 KR860003011A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH4791/84 1984-10-05
CH4791/84A CH660305A5 (de) 1984-10-05 1984-10-05 Wasserloesliche pharmazeutische zusammensetzungen auf der basis von salzen der (-)cis-1,2-epoxypropylphosphonsaeure mit aminosaeuren.

Publications (1)

Publication Number Publication Date
KR860003011A true KR860003011A (ko) 1986-05-19

Family

ID=4282601

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850007327A KR860003011A (ko) 1984-10-05 1985-10-05 (-)시스-1,2-에폭시프로필포스폰산과 아미노산과의 염을 함유하는 수용성 제약 조성물

Country Status (12)

Country Link
US (1) US4783449A (ko)
JP (1) JPS62223122A (ko)
KR (1) KR860003011A (ko)
AT (1) AT383735B (ko)
BE (1) BE903368A (ko)
CH (1) CH660305A5 (ko)
DE (1) DE3535355A1 (ko)
ES (1) ES8608861A1 (ko)
FR (1) FR2572934B1 (ko)
GB (1) GB2165153B (ko)
IT (1) IT1201478B (ko)
NL (1) NL8502713A (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4003054A1 (de) * 1990-02-02 1991-08-08 Hoechst Ag Verwendung von benzylphosphonsaeurederivaten zur behandlung von durch viren verursachte krankheiten
ITMI20021725A1 (it) * 2002-08-01 2002-10-31 Zambon Spa Composizioni farmaceutiche ad attivita' antibiotica.

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH310498A (de) * 1951-11-14 1955-10-31 Waldhof Zellstoff Fab Verfahren zur Stabilisierung von Alkalisalzen von Adenosinpolyphosphorsäuren.
DE1492204A1 (de) * 1962-04-14 1969-07-17 Uhlenbroock Dr Med Kurt Verfahren zur Herstellung von stabilen,waessrigen Injektionsloesungen von Monophenyl-4-butylpyrazolidin-Verbindungen
GB1195612A (en) * 1967-04-13 1970-06-17 Sumitomo Chemical Co An Injection
BE756953A (fr) * 1969-10-02 1971-04-01 Merck & Co Inc Potentialisation d'antibiotiques
IT1161974B (it) * 1978-02-02 1987-03-18 Italchemi Spa Derivti dell acido cis.i 2 epossipropilfosfonico loro procedimento di preparazione e composizioni farmaceutiche che li contengono
IT1112282B (it) * 1978-07-19 1986-01-13 Zambon Spa Bis-(2-ammonio-2-idrossimetil-1,3-propandiolo)(2r-cis)-(3-metilossiranil)fosfonato
IT1097578B (it) * 1978-07-31 1985-08-31 Italchemi Spa Metodo per la preparazione di sali dell'acido (-)
IT1124610B (it) * 1979-10-18 1986-05-07 Zambo Spa Mono(2-ammonio-2-idrossimetil-1,3-propandiolo) (2r-cis)-(o-metilossiranil)fosfonato
AU565425B2 (en) * 1982-11-01 1987-09-17 Stichting Katholieke Universiteit Sparsomycin (sc-rs) derivative

Also Published As

Publication number Publication date
ES547624A0 (es) 1986-09-01
ES8608861A1 (es) 1986-09-01
GB2165153A (en) 1986-04-09
AT383735B (de) 1987-08-10
GB2165153B (en) 1988-03-23
US4783449A (en) 1988-11-08
IT8522366A0 (it) 1985-10-04
ATA286985A (de) 1987-01-15
DE3535355A1 (de) 1986-04-17
GB8524551D0 (en) 1985-11-06
IT1201478B (it) 1989-02-02
FR2572934B1 (fr) 1988-10-28
NL8502713A (nl) 1986-05-01
JPS62223122A (ja) 1987-10-01
FR2572934A1 (fr) 1986-05-16
CH660305A5 (de) 1987-04-15
BE903368A (nl) 1986-02-03

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