DE3863859D1 - Stabile, injizierbare loesungen von salzen von vincristin. - Google Patents
Stabile, injizierbare loesungen von salzen von vincristin.Info
- Publication number
- DE3863859D1 DE3863859D1 DE8888103072T DE3863859T DE3863859D1 DE 3863859 D1 DE3863859 D1 DE 3863859D1 DE 8888103072 T DE8888103072 T DE 8888103072T DE 3863859 T DE3863859 T DE 3863859T DE 3863859 D1 DE3863859 D1 DE 3863859D1
- Authority
- DE
- Germany
- Prior art keywords
- salts
- stable
- vincristin
- injectable solutions
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical class C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 title 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 abstract 2
- 241000863480 Vinca Species 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 2
- 239000000539 dimer Substances 0.000 abstract 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000008351 acetate buffer Substances 0.000 abstract 1
- 229960001484 edetic acid Drugs 0.000 abstract 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 abstract 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 abstract 1
- 229960002216 methylparaben Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000003755 preservative agent Substances 0.000 abstract 1
- 230000002335 preservative effect Effects 0.000 abstract 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 abstract 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 abstract 1
- 229960003415 propylparaben Drugs 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL83086A IL83086A (en) | 1987-07-06 | 1987-07-06 | Stable,injectable solutions of vincristine salts |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3863859D1 true DE3863859D1 (de) | 1991-08-29 |
Family
ID=11057953
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8888103072T Expired - Lifetime DE3863859D1 (de) | 1987-07-06 | 1988-03-01 | Stabile, injizierbare loesungen von salzen von vincristin. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4883805A (de) |
| EP (1) | EP0298192B1 (de) |
| JP (1) | JPS6416724A (de) |
| AT (1) | ATE65401T1 (de) |
| CA (1) | CA1303992C (de) |
| DE (1) | DE3863859D1 (de) |
| ES (1) | ES2028917T3 (de) |
| IL (1) | IL83086A (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU204995B (en) * | 1989-11-07 | 1992-03-30 | Richter Gedeon Vegyeszet | Process for producing pharmaceutical composition comprising alkaloid with bis-indole skeleton, with antitumour activity and suitable fr parenteral purposes |
| GB9405593D0 (en) * | 1994-03-22 | 1994-05-11 | Zeneca Ltd | Pharmaceutical compositions |
| DE19818802A1 (de) * | 1998-04-27 | 1999-10-28 | Dresden Arzneimittel | Stabile Mitoxantron-Lösungen |
| AU2001256714A1 (en) | 2000-05-15 | 2001-11-26 | Kissei Pharmaceutical Co. Ltd. | Water-based liquid preparation |
| US20020035107A1 (en) | 2000-06-20 | 2002-03-21 | Stefan Henke | Highly concentrated stable meloxicam solutions |
| US8992980B2 (en) | 2002-10-25 | 2015-03-31 | Boehringer Ingelheim Vetmedica Gmbh | Water-soluble meloxicam granules |
| PL2368553T3 (pl) | 2003-04-08 | 2015-05-29 | Progenics Pharm Inc | Preparaty farmaceutyczne zawierające metylonaltrekson |
| FR2863891B1 (fr) * | 2003-12-23 | 2006-03-24 | Pf Medicament | Composition pharmaceutique de vinflunine destinee a une administration parentale, procede de preparation et utilisation |
| EP1568369A1 (de) | 2004-02-23 | 2005-08-31 | Boehringer Ingelheim Vetmedica Gmbh | Verwendung von Meloxicam zur Behandlung von Atemwegserkrankungen bei Schweinen |
| US7923037B2 (en) * | 2006-10-05 | 2011-04-12 | Ikaria, Inc. | Liquid chalcogenide compositions and methods of manufacturing and using the same |
| JP6099557B2 (ja) * | 2013-12-27 | 2017-03-22 | 富士フイルム株式会社 | 注射液製剤及びその製造方法 |
| US11058679B2 (en) | 2015-08-01 | 2021-07-13 | Sun Pharmaceutical Industries Ltd. | Dosage form of vinca alkaloid drug |
| CN114699369A (zh) * | 2022-05-19 | 2022-07-05 | 青岛农业大学 | 一种盐酸溴己新注射液及其制备方法和应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3248291A (en) * | 1963-08-19 | 1966-04-26 | Hoffmann La Roche | Stabilized thioxanthene derivatives and method of using the same |
| GB1254057A (en) * | 1969-04-24 | 1971-11-17 | Louisette Olivier | Improvements in or relating to therapeutical composition containing vincamine |
| GB2020180B (en) * | 1978-05-08 | 1982-08-25 | Nelson Res & Dev | Ophthalmic compositions containingcolchicine or vinblastinr |
| US4619935A (en) * | 1983-03-17 | 1986-10-28 | Eli Lilly And Company | Stable oncolytic formulations |
| US4708962A (en) * | 1984-12-17 | 1987-11-24 | Harbor Branch Oceanographic Institution, Inc. | Antiviral and antitumor cyclohexadienone compositions |
| US4707498A (en) * | 1986-01-14 | 1987-11-17 | Merrell Dow Pharmaceuticals Inc. | Fluorinated diaminoalkyne derivatives |
-
1987
- 1987-07-06 IL IL83086A patent/IL83086A/xx unknown
- 1987-07-28 US US07/078,805 patent/US4883805A/en not_active Expired - Fee Related
-
1988
- 1988-03-01 EP EP88103072A patent/EP0298192B1/de not_active Expired - Lifetime
- 1988-03-01 ES ES198888103072T patent/ES2028917T3/es not_active Expired - Lifetime
- 1988-03-01 DE DE8888103072T patent/DE3863859D1/de not_active Expired - Lifetime
- 1988-03-01 AT AT88103072T patent/ATE65401T1/de not_active IP Right Cessation
- 1988-03-07 CA CA000560733A patent/CA1303992C/en not_active Expired - Lifetime
- 1988-03-11 JP JP63056522A patent/JPS6416724A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| EP0298192A1 (de) | 1989-01-11 |
| CA1303992C (en) | 1992-06-23 |
| IL83086A0 (en) | 1987-12-31 |
| ES2028917T3 (es) | 1992-07-16 |
| AU604094B2 (en) | 1990-12-06 |
| IL83086A (en) | 1991-03-10 |
| US4883805A (en) | 1989-11-28 |
| AU1257888A (en) | 1989-01-12 |
| EP0298192B1 (de) | 1991-07-24 |
| ATE65401T1 (de) | 1991-08-15 |
| JPH0525857B2 (de) | 1993-04-14 |
| JPS6416724A (en) | 1989-01-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |