ATE210127T1 - 6-substituierte mycophenolsäurederivate mit immun suppressiver wirkung - Google Patents

6-substituierte mycophenolsäurederivate mit immun suppressiver wirkung

Info

Publication number
ATE210127T1
ATE210127T1 AT95911698T AT95911698T ATE210127T1 AT E210127 T1 ATE210127 T1 AT E210127T1 AT 95911698 T AT95911698 T AT 95911698T AT 95911698 T AT95911698 T AT 95911698T AT E210127 T1 ATE210127 T1 AT E210127T1
Authority
AT
Austria
Prior art keywords
mycophenolic acid
acid derivatives
immune suppressive
suppressive effects
substituted mycophenolic
Prior art date
Application number
AT95911698T
Other languages
English (en)
Inventor
Dean R Artis
Todd R Elworthy
Ronald C Hawley
David G Loughhead
David J Morgans Jr
Peter H Nelson
John W Patterson Jr
Eric B Sjogren
David B Smith
Ann Marie Waltos
Robert J Weikert
Alicia C Garcia
Mario F Zertuche
Fidencio F Andrade
Maria T L Hernandez
Francisco X T Murra
Teresa A T Martin
Original Assignee
Syntex Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Llc filed Critical Syntex Llc
Application granted granted Critical
Publication of ATE210127T1 publication Critical patent/ATE210127T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
AT95911698T 1994-02-18 1995-02-16 6-substituierte mycophenolsäurederivate mit immun suppressiver wirkung ATE210127T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/198,725 US5444072A (en) 1994-02-18 1994-02-18 6-substituted mycophenolic acid and derivatives
PCT/US1995/001785 WO1995022536A1 (en) 1994-02-18 1995-02-16 6-substituted mycophenolic and derivatives with immunosuppressive activity

Publications (1)

Publication Number Publication Date
ATE210127T1 true ATE210127T1 (de) 2001-12-15

Family

ID=22734546

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95911698T ATE210127T1 (de) 1994-02-18 1995-02-16 6-substituierte mycophenolsäurederivate mit immun suppressiver wirkung

Country Status (28)

Country Link
US (2) US5444072A (de)
EP (1) EP0745075B1 (de)
JP (1) JPH09509172A (de)
CN (1) CN1141040A (de)
AT (1) ATE210127T1 (de)
AU (1) AU1917095A (de)
BR (1) BR9506835A (de)
CA (1) CA2183533A1 (de)
CO (1) CO4340735A1 (de)
DE (1) DE69524389T2 (de)
DK (1) DK0745075T3 (de)
ES (1) ES2168359T3 (de)
FI (1) FI963221A (de)
GT (1) GT199500006A (de)
HK (1) HK1012634A1 (de)
HR (1) HRP950071A2 (de)
IL (1) IL112667A (de)
IS (1) IS4265A (de)
MY (1) MY130110A (de)
PE (1) PE23096A1 (de)
PH (1) PH31406A (de)
PT (1) PT745075E (de)
SI (1) SI0745075T1 (de)
SV (1) SV1995000006A (de)
TW (1) TW369532B (de)
UY (2) UY23909A1 (de)
WO (1) WO1995022536A1 (de)
ZA (1) ZA951295B (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5807876A (en) * 1996-04-23 1998-09-15 Vertex Pharmaceuticals Incorporated Inhibitors of IMPDH enzyme
US6054472A (en) * 1996-04-23 2000-04-25 Vertex Pharmaceuticals, Incorporated Inhibitors of IMPDH enzyme
CN1515248A (zh) 1996-04-23 2004-07-28 ��̩��˹ҩ��ɷ����޹�˾ 用作肌苷-5'-一磷酸脱氢酶抑制剂的脲衍生物
US6128582A (en) * 1996-04-30 2000-10-03 Vertex Pharmaceuticals Incorporated Molecules comprising an IMPDH-like binding pocket and encoded data storage medium capable of graphically displaying them
WO1998040381A1 (en) 1997-03-14 1998-09-17 Vertex Pharmaceuticals Incorporated Inhibitors of impdh enzyme
EP1366766A1 (de) * 1997-03-14 2003-12-03 Vertex Pharmaceuticals Incorporated IMPDH Enzym-Inhibitoren
US5932600A (en) * 1997-03-14 1999-08-03 Vertex Pharmaceuticals Incorporated Inhibitors of IMPDH enzyme
AU6037499A (en) * 1998-09-14 2000-04-03 Vertex Pharmaceuticals Incorporated Methods of treating viral disease
US6420403B1 (en) 1998-10-29 2002-07-16 Edwin J. Iwanowicz Inhibitors of IMPDH enzyme
JP2002528533A (ja) * 1998-10-29 2002-09-03 ブリストル−マイヤーズ スクイブ カンパニー 酵素ｉｍｐｄｈの新規なインヒビター
US6596747B2 (en) 1998-10-29 2003-07-22 Bristol-Myers Squibb Company Compounds derived from an amine nucleus and pharmaceutical compositions comprising same
AU764479B2 (en) 1998-10-29 2003-08-21 Bristol-Myers Squibb Company Compounds derived from an amine nucleus that are inhibitors of IMPDH enzyme
US6514979B1 (en) 1999-03-03 2003-02-04 University Of Maryland Biotechnology Institute Synergistic combinations of guanosine analog reverse transcriptase inhibitors and inosine monophosphate dehydrogenese inhibitors and uses therefor
NZ514540A (en) * 1999-03-19 2003-11-28 Vertex Pharma Phenyl derivative useful as inhibitors of IMPDH enzyme
US6107052A (en) * 1999-06-09 2000-08-22 Roche Diagnostics Corporation Enzymatic measurement of mycophenolic acid
US6811998B2 (en) 1999-06-25 2004-11-02 Roche Diagnostics Operations, Inc. Conjugates of uncompetitive inhibitors of inosine monophosphate dehydrogenase
US6395763B1 (en) 1999-06-25 2002-05-28 Vertex Pharmaceuticals Incorporated Prodrugs of carbamate inhibitors of IMPDH
EP1276739A2 (de) * 2000-04-24 2003-01-22 Bristol-Myers Squibb Company Heterozyklische verbindungen und deren verwendung als impdh enzym inhibitoren
US7179791B2 (en) * 2001-01-11 2007-02-20 Duke University Inhibiting GS-FDH to modulate NO bioactivity
WO2003035066A1 (en) * 2001-10-23 2003-05-01 Celltech R & D Limited 2-aminoquinolone derivatives for use as impdh inhibitors
TW200301698A (en) * 2001-12-21 2003-07-16 Bristol Myers Squibb Co Acridone inhibitors of IMPDH enzyme
DE60331367D1 (de) 2002-12-30 2010-04-01 Angiotech Int Ag Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung
US20050187170A1 (en) * 2003-06-16 2005-08-25 Biocryst Pharmaceuticals, Inc. Enhancing the efficiency of RNA polymerase inhibitors by using inosine monophosphate dehydrogenase inhibitors
US7276362B2 (en) 2004-01-30 2007-10-02 Roche Diagnostics Operations, Inc. Recombinant histidine-tagged inosine monophosphate dehydrogenase polypeptides
CA2571710A1 (en) 2004-06-24 2006-11-02 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
CN102952105A (zh) * 2011-08-26 2013-03-06 中国科学院上海药物研究所 一类霉酚酸衍生物、其制备方法和用途
CN104597238B (zh) * 2015-01-27 2016-08-17 苏州博源医疗科技有限公司 一种霉酚酸均相酶免疫检测试剂及其制备和检测方法
US10603299B2 (en) 2016-06-02 2020-03-31 Steven Baranowitz Prevention and treatment of viral infections
WO2017210262A1 (en) 2016-06-02 2017-12-07 Steven Baranowitz Prevention and treatment of viral infections
CN106674170B (zh) * 2016-12-30 2019-03-15 国家海洋局第三海洋研究所 三种苯酚类衍生物的制备方法及其在制备抗hiv药物中的应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5542995B2 (de) * 1972-02-24 1980-11-04
US3825571A (en) * 1971-07-31 1974-07-23 Chugai Pharmaceutical Co Ltd Mycophenolic acid derivatives
JPS5529994B2 (de) * 1972-03-02 1980-08-07
US4686234A (en) * 1985-11-27 1987-08-11 Syntex (U.S.A) Inc. Mycophenolic acid derivatives in the treatment of inflammatory diseases, in particular rheumatoid arthritis
US4725622A (en) * 1986-01-23 1988-02-16 Syntex (U.S.A.) Inc. Mycophenolic acid derivatives in the treatment of rheumatoid arthritis
US4959387A (en) * 1986-01-23 1990-09-25 Syntex (U.S.A.) Inc. Mycophenolic acid derivatives in the treatment of rheumatoid arthritis
US4727069A (en) * 1987-01-30 1988-02-23 Syntex (U.S.A.) Inc. Heterocyclic aminoalkyl esters of mycophenolic acid, derivatives thereof and pharmaceutical compositions
US4861776A (en) * 1987-01-30 1989-08-29 Syntex (U.S.A) Inc. Heterocyclic aminoalkyl esters of mycophenolic acid and derivatives thereof, compositions and use
US4748173A (en) * 1987-01-30 1988-05-31 Syntex (U.S.A.) Inc. Heterocyclic aminoalkyl esters of mycophenolic acid and derivatives thereof and pharmaceutical compositions
US4753935A (en) * 1987-01-30 1988-06-28 Syntex (U.S.A.) Inc. Morpholinoethylesters of mycophenolic acid and pharmaceutical compositions
JPH0637486B2 (ja) * 1988-05-18 1994-05-18 三共株式会社 新規抗生物質フタレキシンおよびその製造法
CA2086642C (en) * 1992-01-09 2004-06-15 Randall E. Morris Method of treating hyperproliferative vascular disease
US5247083A (en) * 1992-07-10 1993-09-21 Syntex (U.S.A.) Inc. Direct esterification of mycophenolic acid

Also Published As

Publication number Publication date
PT745075E (pt) 2002-05-31
IL112667A0 (en) 1995-05-26
UY25263A1 (es) 2001-01-31
BR9506835A (pt) 1997-10-14
FI963221A (fi) 1996-10-16
AU1917095A (en) 1995-09-04
DE69524389T2 (de) 2002-08-29
WO1995022536A1 (en) 1995-08-24
FI963221A0 (fi) 1996-08-16
DE69524389D1 (de) 2002-01-17
ZA951295B (en) 1996-08-16
IL112667A (en) 2000-07-16
SI0745075T1 (en) 2002-06-30
UY23909A1 (es) 1995-03-06
MY130110A (en) 2007-06-29
PH31406A (en) 1998-10-29
EP0745075B1 (de) 2001-12-05
JPH09509172A (ja) 1997-09-16
HRP950071A2 (en) 1997-06-30
US5536747A (en) 1996-07-16
EP0745075A1 (de) 1996-12-04
HK1012634A1 (en) 1999-08-06
ES2168359T3 (es) 2002-06-16
GT199500006A (es) 1996-08-10
CA2183533A1 (en) 1995-08-24
CN1141040A (zh) 1997-01-22
SV1995000006A (es) 1996-09-30
CO4340735A1 (es) 1996-07-30
PE23096A1 (es) 1996-06-04
DK0745075T3 (da) 2002-03-04
IS4265A (is) 1995-08-19
TW369532B (en) 1999-09-11
US5444072A (en) 1995-08-22

Similar Documents

Publication Publication Date Title
ATE210127T1 (de) 6-substituierte mycophenolsäurederivate mit immun suppressiver wirkung
DE69524864T2 (de) 4-amino-derivate der mycophenolsäure mit immun suppressiver wirkung
BR9506819A (pt) Derivados de ácido micofenólico substituídos na posiçao 5
ATE210126T1 (de) 4-amino-6-substituierte mycophenolsäurederivate mit immunsuppressiver wirkung
BR9506838A (pt) Derivados de ácido micofenólico substituídos na posição 5

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee