CO4340735A1 - Acido micofenolico 6-sustituido y derivados y procedimiento para su preparacion - Google Patents
Acido micofenolico 6-sustituido y derivados y procedimiento para su preparacionInfo
- Publication number
- CO4340735A1 CO4340735A1 CO95005931A CO95005931A CO4340735A1 CO 4340735 A1 CO4340735 A1 CO 4340735A1 CO 95005931 A CO95005931 A CO 95005931A CO 95005931 A CO95005931 A CO 95005931A CO 4340735 A1 CO4340735 A1 CO 4340735A1
- Authority
- CO
- Colombia
- Prior art keywords
- mycophenolic acid
- derivatives
- procedure
- preparation
- substituted mycophenolic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/83—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
REIVINDICACION NUMERO UN COMPUESTO DE FORMULA FIGURA 1 EN DONDE: R1 ES H o C(O)R10, EN DONDE R10 ES UN ALQUILO INFERIOR, ARILO O NH-ARILO; R2 ES ALQUILO INFERIOR, CICLOALQUILO, VINILO, FLUOROVINILO, DIFLUOROVINILO, TRIFLUOROVINILO, AL- QUENILO, -C=C-R11, ALENILO, CHO O CH2OR12, EN DONDE R11 ES H O ALQUILO INFERIOR, Y R12 ES H o 4-METOXIBENCILO; Y Z ES UNA CADENA LATERAL SELECCIONADA DE LA FORMULA ZA, ZB, ZC, ZD, ZE, ZF, ZG, Y ZH: FIGURA 2 EN DONDE: Z1 ES H, ALQUILO INFERIOR, HALO O CF3; Z2 ES H, ALQUILO INFERIOR, ALCOXI INFERIOR, ARILO, O CH2-Z11, EN DONDE Z11 ES HALO, CN, ARILO O HETEROARILO; Z3 ES H, ALQUILO INFERIOR, ALQUENILO INFERIOR, AL- COXI INFERIOR, FENILO O ALQUILO -S(O)n INFERIOR, EN DONDE m ES 0, 1 o 2; Z4 ES H, ALQUILO INFERIOR O FENILO; o Z3 y Z4 TOMADOS JUNTOS CON EL CARBON AL CUAL ES- TAN UNIDOS FORMAN UN CICLO ALQUILO DE 3 A 5 ATOMOS DE CARBON; Y G ES OH, ALCOXI INFERIOR, TIOALQUILO INFERIOR NG1G2, O-(CH2)n-NG1G2 o O-(CH2)n-N=G3, EN DONDE n ES UN ENTERO ENTRE 1 Y 6, G1 ES H o ALQUILO INFERIOR, G2 ES H o ALQUILO INFERIOR, Y =G3 ES ALQUILENO INFERIOR DE 4 A 6 ATOMOS DE CAR- BON, O ALQUILENO INFERIOR DE 3 A 5 ATOMOS DE CAR- BON MAS UN MIEMBRO QUE ES -O-, -S-, o -N(G)- EN DONDE G4 ES H o ALQUILO INFERIOR; O FIGURA 3 EN DONDE Z5 ES H, O ALQUILO INFERIOR; Z8 ES H, ALQUILO INFERIOR O FORMA UN DOBLE ENLACE CON D2; D1 y D2 JUNTO CON SU ATOMOS DE CARBON ADYACENTES FORMAN UN ANILLO OPCIONALMENTE SUSTITUIDO, SATURA- DO O INSATURADO, CARBOXICLICO O HETEROCICLICO DE 3 A 7 ATOMOS; y G ES COMO SE DEFINIO ANTERIORMENTE; O FIGURA 4 EN DONDE: Z8 ES H o ALQUILO INFERIOR; Y Z5 y G SON COMO SE DEFINIERON ANTERIORMENTE; O FIGURA 5 EN DONDE: D3 ES -CH2- o -CH2-CH2-; Y G ES COMO SE DEFINIO ANTERIORMENTE; O FIGURA 6 EN DONDE: Z6 ES H, ALQUILO INFERIOR, COOH, NH2, ACIDO O HALO Z7 ES H, ALQUILO INFERIOR O HALO; Y Z5 y G SON COMO SE DEFINIERON ANTERIORMENTE; O FIGURA 7 EN DONDE: Z1 y G SON COMO SE DEFINIERON ANTERIORMENTE; O FIGURA 8 D3, Z2, Z3, Z4 y G SON COMO SE DEFINIERON ANTE- RIORMENTE; O FIGURA 9 EN DONDE: D4 ES -CH2-, -CH2-CH2-, -CH2-CH2-CH2-, -O-, o -O-CH2-; Y Z1 y G SON COMO SE DEFINIERON ANTERIORMENTE; Y LAS SALES DE ELLOS FARMACEUTICAMENTE ACEPTABLES.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/198,725 US5444072A (en) | 1994-02-18 | 1994-02-18 | 6-substituted mycophenolic acid and derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO4340735A1 true CO4340735A1 (es) | 1996-07-30 |
Family
ID=22734546
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO95005931A CO4340735A1 (es) | 1994-02-18 | 1995-02-16 | Acido micofenolico 6-sustituido y derivados y procedimiento para su preparacion |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US5444072A (es) |
| EP (1) | EP0745075B1 (es) |
| JP (1) | JPH09509172A (es) |
| CN (1) | CN1141040A (es) |
| AT (1) | ATE210127T1 (es) |
| AU (1) | AU1917095A (es) |
| BR (1) | BR9506835A (es) |
| CA (1) | CA2183533A1 (es) |
| CO (1) | CO4340735A1 (es) |
| DE (1) | DE69524389T2 (es) |
| DK (1) | DK0745075T3 (es) |
| ES (1) | ES2168359T3 (es) |
| FI (1) | FI963221A (es) |
| GT (1) | GT199500006A (es) |
| HK (1) | HK1012634A1 (es) |
| HR (1) | HRP950071A2 (es) |
| IL (1) | IL112667A (es) |
| IS (1) | IS4265A (es) |
| MY (1) | MY130110A (es) |
| PE (1) | PE23096A1 (es) |
| PH (1) | PH31406A (es) |
| PT (1) | PT745075E (es) |
| SI (1) | SI0745075T1 (es) |
| SV (1) | SV1995000006A (es) |
| TW (1) | TW369532B (es) |
| UY (2) | UY23909A1 (es) |
| WO (1) | WO1995022536A1 (es) |
| ZA (1) | ZA951295B (es) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6054472A (en) * | 1996-04-23 | 2000-04-25 | Vertex Pharmaceuticals, Incorporated | Inhibitors of IMPDH enzyme |
| US5807876A (en) * | 1996-04-23 | 1998-09-15 | Vertex Pharmaceuticals Incorporated | Inhibitors of IMPDH enzyme |
| SK286662B6 (sk) | 1996-04-23 | 2009-03-05 | Vertex Pharmaceuticals Incorporated | Deriváty močoviny, farmaceutické prostriedky, ktoré ich obsahujú, a ich použitie ako inhibítorov aktivity IMPDH enzýmu |
| US6128582A (en) * | 1996-04-30 | 2000-10-03 | Vertex Pharmaceuticals Incorporated | Molecules comprising an IMPDH-like binding pocket and encoded data storage medium capable of graphically displaying them |
| EP1366766A1 (en) * | 1997-03-14 | 2003-12-03 | Vertex Pharmaceuticals Incorporated | Inhibitors of IMPDH enzyme |
| ES2201452T3 (es) * | 1997-03-14 | 2004-03-16 | Vertex Pharmaceuticals Incorporated | Inhibidores de la enzima impdh. |
| US5932600A (en) * | 1997-03-14 | 1999-08-03 | Vertex Pharmaceuticals Incorporated | Inhibitors of IMPDH enzyme |
| WO2000015210A2 (en) * | 1998-09-14 | 2000-03-23 | Vertex Pharmaceuticals Incorporated | Use of mycophenol acid and its derivatives for the treatment of virus diseases |
| US6596747B2 (en) | 1998-10-29 | 2003-07-22 | Bristol-Myers Squibb Company | Compounds derived from an amine nucleus and pharmaceutical compositions comprising same |
| WO2000026197A1 (en) * | 1998-10-29 | 2000-05-11 | Bristol-Myers Squibb Company | Novel inhibitors of impdh enzyme |
| WO2000025780A1 (en) | 1998-10-29 | 2000-05-11 | Bristol-Myers Squibb Company | Compounds derived from an amine nucleus that are inhibitors of impdh enzyme |
| US6420403B1 (en) | 1998-10-29 | 2002-07-16 | Edwin J. Iwanowicz | Inhibitors of IMPDH enzyme |
| US6514979B1 (en) | 1999-03-03 | 2003-02-04 | University Of Maryland Biotechnology Institute | Synergistic combinations of guanosine analog reverse transcriptase inhibitors and inosine monophosphate dehydrogenese inhibitors and uses therefor |
| EP1964561A1 (en) | 1999-03-19 | 2008-09-03 | Vertex Pharmaceuticals Incorporated | Inhibitors of IMPDH enzyme |
| US6107052A (en) * | 1999-06-09 | 2000-08-22 | Roche Diagnostics Corporation | Enzymatic measurement of mycophenolic acid |
| US6811998B2 (en) | 1999-06-25 | 2004-11-02 | Roche Diagnostics Operations, Inc. | Conjugates of uncompetitive inhibitors of inosine monophosphate dehydrogenase |
| ATE248835T1 (de) | 1999-06-25 | 2003-09-15 | Vertex Pharma | Prodrugs von impdh-inhibierenden carbamaten |
| EP1276739A2 (en) * | 2000-04-24 | 2003-01-22 | Bristol-Myers Squibb Company | Heterocycles that are inhibitors of impdh enzyme |
| US7179791B2 (en) * | 2001-01-11 | 2007-02-20 | Duke University | Inhibiting GS-FDH to modulate NO bioactivity |
| WO2003035066A1 (en) * | 2001-10-23 | 2003-05-01 | Celltech R & D Limited | 2-aminoquinolone derivatives for use as impdh inhibitors |
| TW200301698A (en) * | 2001-12-21 | 2003-07-16 | Bristol Myers Squibb Co | Acridone inhibitors of IMPDH enzyme |
| EP2181704B1 (en) | 2002-12-30 | 2015-05-06 | Angiotech International Ag | Drug delivery from rapid gelling polymer composition |
| US20050187170A1 (en) * | 2003-06-16 | 2005-08-25 | Biocryst Pharmaceuticals, Inc. | Enhancing the efficiency of RNA polymerase inhibitors by using inosine monophosphate dehydrogenase inhibitors |
| US7276362B2 (en) | 2004-01-30 | 2007-10-02 | Roche Diagnostics Operations, Inc. | Recombinant histidine-tagged inosine monophosphate dehydrogenase polypeptides |
| CA2571710A1 (en) | 2004-06-24 | 2006-11-02 | Nicholas Valiante | Small molecule immunopotentiators and assays for their detection |
| CN102952105A (zh) * | 2011-08-26 | 2013-03-06 | 中国科学院上海药物研究所 | 一类霉酚酸衍生物、其制备方法和用途 |
| CN104597238B (zh) * | 2015-01-27 | 2016-08-17 | 苏州博源医疗科技有限公司 | 一种霉酚酸均相酶免疫检测试剂及其制备和检测方法 |
| CA3026241A1 (en) | 2016-06-02 | 2017-12-07 | Steven Baranowitz | Prevention and treatment of viral infections |
| US12011429B2 (en) | 2016-06-02 | 2024-06-18 | Steven Baranowitz | Prevention and treatment of viral infections |
| US10603299B2 (en) | 2016-06-02 | 2020-03-31 | Steven Baranowitz | Prevention and treatment of viral infections |
| CN106674170B (zh) * | 2016-12-30 | 2019-03-15 | 国家海洋局第三海洋研究所 | 三种苯酚类衍生物的制备方法及其在制备抗hiv药物中的应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3825571A (en) * | 1971-07-31 | 1974-07-23 | Chugai Pharmaceutical Co Ltd | Mycophenolic acid derivatives |
| JPS5542995B2 (es) * | 1972-02-24 | 1980-11-04 | ||
| JPS5529994B2 (es) * | 1972-03-02 | 1980-08-07 | ||
| US4686234A (en) * | 1985-11-27 | 1987-08-11 | Syntex (U.S.A) Inc. | Mycophenolic acid derivatives in the treatment of inflammatory diseases, in particular rheumatoid arthritis |
| US4725622A (en) * | 1986-01-23 | 1988-02-16 | Syntex (U.S.A.) Inc. | Mycophenolic acid derivatives in the treatment of rheumatoid arthritis |
| US4959387A (en) * | 1986-01-23 | 1990-09-25 | Syntex (U.S.A.) Inc. | Mycophenolic acid derivatives in the treatment of rheumatoid arthritis |
| US4753935A (en) * | 1987-01-30 | 1988-06-28 | Syntex (U.S.A.) Inc. | Morpholinoethylesters of mycophenolic acid and pharmaceutical compositions |
| US4727069A (en) * | 1987-01-30 | 1988-02-23 | Syntex (U.S.A.) Inc. | Heterocyclic aminoalkyl esters of mycophenolic acid, derivatives thereof and pharmaceutical compositions |
| US4748173A (en) * | 1987-01-30 | 1988-05-31 | Syntex (U.S.A.) Inc. | Heterocyclic aminoalkyl esters of mycophenolic acid and derivatives thereof and pharmaceutical compositions |
| US4861776A (en) * | 1987-01-30 | 1989-08-29 | Syntex (U.S.A) Inc. | Heterocyclic aminoalkyl esters of mycophenolic acid and derivatives thereof, compositions and use |
| JPH0637486B2 (ja) * | 1988-05-18 | 1994-05-18 | 三共株式会社 | 新規抗生物質フタレキシンおよびその製造法 |
| CA2086642C (en) * | 1992-01-09 | 2004-06-15 | Randall E. Morris | Method of treating hyperproliferative vascular disease |
| US5247083A (en) * | 1992-07-10 | 1993-09-21 | Syntex (U.S.A.) Inc. | Direct esterification of mycophenolic acid |
-
1994
- 1994-02-18 US US08/198,725 patent/US5444072A/en not_active Expired - Fee Related
-
1995
- 1995-02-16 UY UY23909A patent/UY23909A1/es not_active IP Right Cessation
- 1995-02-16 BR BR9506835A patent/BR9506835A/pt not_active IP Right Cessation
- 1995-02-16 EP EP95911698A patent/EP0745075B1/en not_active Expired - Lifetime
- 1995-02-16 AT AT95911698T patent/ATE210127T1/de not_active IP Right Cessation
- 1995-02-16 TW TW084101397A patent/TW369532B/zh active
- 1995-02-16 MY MYPI95000395A patent/MY130110A/en unknown
- 1995-02-16 CO CO95005931A patent/CO4340735A1/es unknown
- 1995-02-16 DK DK95911698T patent/DK0745075T3/da active
- 1995-02-16 IS IS4265A patent/IS4265A/is unknown
- 1995-02-16 PE PE1995262076A patent/PE23096A1/es not_active Application Discontinuation
- 1995-02-16 HR HR08/198,725A patent/HRP950071A2/hr not_active Application Discontinuation
- 1995-02-16 DE DE69524389T patent/DE69524389T2/de not_active Expired - Fee Related
- 1995-02-16 IL IL11266795A patent/IL112667A/xx not_active IP Right Cessation
- 1995-02-16 PT PT95911698T patent/PT745075E/pt unknown
- 1995-02-16 SV SV1995000006A patent/SV1995000006A/es unknown
- 1995-02-16 AU AU19170/95A patent/AU1917095A/en not_active Abandoned
- 1995-02-16 ZA ZA951295A patent/ZA951295B/xx unknown
- 1995-02-16 PH PH49979A patent/PH31406A/en unknown
- 1995-02-16 ES ES95911698T patent/ES2168359T3/es not_active Expired - Lifetime
- 1995-02-16 SI SI9530530T patent/SI0745075T1/xx unknown
- 1995-02-16 CA CA002183533A patent/CA2183533A1/en not_active Abandoned
- 1995-02-16 JP JP7521866A patent/JPH09509172A/ja not_active Ceased
- 1995-02-16 CN CN95191695A patent/CN1141040A/zh active Pending
- 1995-02-16 WO PCT/US1995/001785 patent/WO1995022536A1/en active IP Right Grant
- 1995-02-17 GT GT199500006A patent/GT199500006A/es unknown
- 1995-05-05 US US08/435,255 patent/US5536747A/en not_active Expired - Fee Related
-
1996
- 1996-08-16 FI FI963221A patent/FI963221A/fi unknown
-
1998
- 1998-11-23 UY UY25263A patent/UY25263A1/es not_active Application Discontinuation
-
1999
- 1999-01-13 HK HK98114094A patent/HK1012634A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HRP950071A2 (en) | 1997-06-30 |
| PT745075E (pt) | 2002-05-31 |
| IL112667A (en) | 2000-07-16 |
| DE69524389D1 (de) | 2002-01-17 |
| SV1995000006A (es) | 1996-09-30 |
| JPH09509172A (ja) | 1997-09-16 |
| IS4265A (is) | 1995-08-19 |
| UY25263A1 (es) | 2001-01-31 |
| AU1917095A (en) | 1995-09-04 |
| DE69524389T2 (de) | 2002-08-29 |
| DK0745075T3 (da) | 2002-03-04 |
| TW369532B (en) | 1999-09-11 |
| UY23909A1 (es) | 1995-03-06 |
| PE23096A1 (es) | 1996-06-04 |
| EP0745075A1 (en) | 1996-12-04 |
| IL112667A0 (en) | 1995-05-26 |
| FI963221A (fi) | 1996-10-16 |
| FI963221A0 (fi) | 1996-08-16 |
| US5536747A (en) | 1996-07-16 |
| PH31406A (en) | 1998-10-29 |
| ES2168359T3 (es) | 2002-06-16 |
| CA2183533A1 (en) | 1995-08-24 |
| EP0745075B1 (en) | 2001-12-05 |
| MY130110A (en) | 2007-06-29 |
| US5444072A (en) | 1995-08-22 |
| BR9506835A (pt) | 1997-10-14 |
| HK1012634A1 (en) | 1999-08-06 |
| CN1141040A (zh) | 1997-01-22 |
| ZA951295B (en) | 1996-08-16 |
| WO1995022536A1 (en) | 1995-08-24 |
| SI0745075T1 (en) | 2002-06-30 |
| ATE210127T1 (de) | 2001-12-15 |
| GT199500006A (es) | 1996-08-10 |
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