PE23096A1 - Acido micofenolico 6-substituido y derivados - Google Patents

Acido micofenolico 6-substituido y derivados

Info

Publication number
PE23096A1
PE23096A1 PE1995262076A PE26207695A PE23096A1 PE 23096 A1 PE23096 A1 PE 23096A1 PE 1995262076 A PE1995262076 A PE 1995262076A PE 26207695 A PE26207695 A PE 26207695A PE 23096 A1 PE23096 A1 PE 23096A1
Authority
PE
Peru
Prior art keywords
mycophenolic acid
derivatives
substituted mycophenolic
substituted
treatment
Prior art date
Application number
PE1995262076A
Other languages
English (en)
Inventor
Ann Marie Waltos
Dean Richard Artis
Todd Richard Elworthy
Ronald Charles Hawley
Jr David John Morgans
Jr John William Patterson
Eric Brian Sjogren
David Bernard Smith
Martin Teresa Alejandra Trejo
Robert James Weikert
Peter Harold Nelson
Garcia Alicia Cervantes
Zertuche Mario Fernandez
Andrade Fidencio Franco
Hernandez Maria Teresa Lara
Murra Francisco Xavier Talamas
David Garrett Loughhead
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of PE23096A1 publication Critical patent/PE23096A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA A: DONDE R1 ES H o C(O)R10 , R10 ES ALQUILO INFERIOR, ARILO, o NH ARILO; R2 ES ALQUILO INFERIOR, CICLOALQUILO, VINILO, CH2OR12 ENTRE OTROS; R11 ES H o ALQUILO INFERIOR; R12 ES H o 4 METOXIBENCIL, Z ES UNA CADENA LATERAL SELECCIONADA DE ZC, ZD, ZF, ZG, ZA, ZB, ZH, ZE SIENDO LAS PRINCIPALES LAS CUATRO ULTIMAS; DONDE ZA ES UNA CADENA LATERAL DONDE INTERVIENE Z1, Z2, Z3, Z4 Y G; EN ZB INTERVIENEN Z5, Z8, D1, D2 Y G; EN ZE PARTICIPAN Z5, Z6, Z7 y G; EN ZH, D4, Z1, y G; DONDE: Z1 ES H, ALQUILO INFERIOR, HALOGENO o CF3, Z2 ES H, ALQUILO INFERIOR, ALCOXILO INFERIOR, ARILO, CH2Z11 (Z11 ES HALOGENO, CN-, ARILO, HETEROARILO), Z3 ES H , ALQUILO INFERIOR, ALQUENILO INFERIOR, ALCOXILO INFERIOR, FENILO o S(O)m ALQUILO INFERIOR DONDE m ES O, 1, 2; Z4 ES H, ALQUILO INFERIOR, HALOGENO O FENILO; Z5 ES H o ALQUILO INFERIOR; Z6 ES H, ALQUILO INFERIOR, COOH, NH2, AZIDA o HALOGENO; Z7 ES H, ALQUILO INFERIOR o HALOGENO; Z6 ES H, ALQUILO INFERIOR O FORMA DOBLE UNION CON D2 EN ZB, D1 Y D2 CON LOS ATOMOS DE CARBONO ADYACENTES FORMAN UN SUSTITUIDO OPCIONAL CARBOCICLICO O HETEROCICLICO, SATURADO O NO; D4 ES CH2, CH2CH2, CH2CH2CH2 o O-CH2, Y G ES OH, ALCOXILO INFERIOR, TIOALQUILO INFERIOR ENTRE OTROS, ESTOS COMPUESTOS SE CARACTERIZAN POR ACTUAR COMO DROGA INMUNOSUPRESORA.
PE1995262076A 1994-02-18 1995-02-16 Acido micofenolico 6-substituido y derivados PE23096A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/198,725 US5444072A (en) 1994-02-18 1994-02-18 6-substituted mycophenolic acid and derivatives

Publications (1)

Publication Number Publication Date
PE23096A1 true PE23096A1 (es) 1996-06-04

Family

ID=22734546

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1995262076A PE23096A1 (es) 1994-02-18 1995-02-16 Acido micofenolico 6-substituido y derivados

Country Status (28)

Country Link
US (2) US5444072A (es)
EP (1) EP0745075B1 (es)
JP (1) JPH09509172A (es)
CN (1) CN1141040A (es)
AT (1) ATE210127T1 (es)
AU (1) AU1917095A (es)
BR (1) BR9506835A (es)
CA (1) CA2183533A1 (es)
CO (1) CO4340735A1 (es)
DE (1) DE69524389T2 (es)
DK (1) DK0745075T3 (es)
ES (1) ES2168359T3 (es)
FI (1) FI963221A (es)
GT (1) GT199500006A (es)
HK (1) HK1012634A1 (es)
HR (1) HRP950071A2 (es)
IL (1) IL112667A (es)
IS (1) IS4265A (es)
MY (1) MY130110A (es)
PE (1) PE23096A1 (es)
PH (1) PH31406A (es)
PT (1) PT745075E (es)
SI (1) SI0745075T1 (es)
SV (1) SV1995000006A (es)
TW (1) TW369532B (es)
UY (2) UY23909A1 (es)
WO (1) WO1995022536A1 (es)
ZA (1) ZA951295B (es)

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Publication number Priority date Publication date Assignee Title
US5807876A (en) * 1996-04-23 1998-09-15 Vertex Pharmaceuticals Incorporated Inhibitors of IMPDH enzyme
US6054472A (en) * 1996-04-23 2000-04-25 Vertex Pharmaceuticals, Incorporated Inhibitors of IMPDH enzyme
NZ332405A (en) 1996-04-23 2000-06-23 Vertex Pharma oxazolyl, thiazolyl or phenyl urea derivatives as inhibitors of inosine monophosphate dehydrogenase enzyme
US6128582A (en) * 1996-04-30 2000-10-03 Vertex Pharmaceuticals Incorporated Molecules comprising an IMPDH-like binding pocket and encoded data storage medium capable of graphically displaying them
ES2201452T3 (es) 1997-03-14 2004-03-16 Vertex Pharmaceuticals Incorporated Inhibidores de la enzima impdh.
US5932600A (en) * 1997-03-14 1999-08-03 Vertex Pharmaceuticals Incorporated Inhibitors of IMPDH enzyme
EP1366766A1 (en) * 1997-03-14 2003-12-03 Vertex Pharmaceuticals Incorporated Inhibitors of IMPDH enzyme
WO2000015210A2 (en) * 1998-09-14 2000-03-23 Vertex Pharmaceuticals Incorporated Use of mycophenol acid and its derivatives for the treatment of virus diseases
US6596747B2 (en) 1998-10-29 2003-07-22 Bristol-Myers Squibb Company Compounds derived from an amine nucleus and pharmaceutical compositions comprising same
AU1707700A (en) 1998-10-29 2000-05-22 Bristol-Myers Squibb Company Novel inhibitors of impdh enzyme
US6420403B1 (en) 1998-10-29 2002-07-16 Edwin J. Iwanowicz Inhibitors of IMPDH enzyme
WO2000025780A1 (en) 1998-10-29 2000-05-11 Bristol-Myers Squibb Company Compounds derived from an amine nucleus that are inhibitors of impdh enzyme
US6514979B1 (en) 1999-03-03 2003-02-04 University Of Maryland Biotechnology Institute Synergistic combinations of guanosine analog reverse transcriptase inhibitors and inosine monophosphate dehydrogenese inhibitors and uses therefor
TR200103428T2 (tr) 1999-03-19 2002-04-22 Vertex Pharmaceuticals Incorporated IMPDH enzim inhibitörleri.
US6107052A (en) * 1999-06-09 2000-08-22 Roche Diagnostics Corporation Enzymatic measurement of mycophenolic acid
US6811998B2 (en) 1999-06-25 2004-11-02 Roche Diagnostics Operations, Inc. Conjugates of uncompetitive inhibitors of inosine monophosphate dehydrogenase
CA2377278C (en) 1999-06-25 2010-03-23 Vertex Pharmaceuticals Incorporated Prodrugs of carbamate inhibitors of impdh
CA2407370A1 (en) * 2000-04-24 2001-11-01 Bristol-Myers Squibb Company Heterocycles that are inhibitors of impdh enzyme
US7179791B2 (en) * 2001-01-11 2007-02-20 Duke University Inhibiting GS-FDH to modulate NO bioactivity
US20030105073A1 (en) * 2001-10-23 2003-06-05 Haughan Alan Findlay Quinolone derivatives
TW200301698A (en) * 2001-12-21 2003-07-16 Bristol Myers Squibb Co Acridone inhibitors of IMPDH enzyme
JP2006516548A (ja) 2002-12-30 2006-07-06 アンジオテック インターナショナル アクツィエン ゲゼルシャフト 迅速ゲル化ポリマー組成物からの薬物送達法
US20050187170A1 (en) * 2003-06-16 2005-08-25 Biocryst Pharmaceuticals, Inc. Enhancing the efficiency of RNA polymerase inhibitors by using inosine monophosphate dehydrogenase inhibitors
US7276362B2 (en) 2004-01-30 2007-10-02 Roche Diagnostics Operations, Inc. Recombinant histidine-tagged inosine monophosphate dehydrogenase polypeptides
US20110104186A1 (en) 2004-06-24 2011-05-05 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
CN102952105A (zh) * 2011-08-26 2013-03-06 中国科学院上海药物研究所 一类霉酚酸衍生物、其制备方法和用途
CN104597238B (zh) * 2015-01-27 2016-08-17 苏州博源医疗科技有限公司 一种霉酚酸均相酶免疫检测试剂及其制备和检测方法
US12011429B2 (en) 2016-06-02 2024-06-18 Steven Baranowitz Prevention and treatment of viral infections
CA3026241A1 (en) 2016-06-02 2017-12-07 Steven Baranowitz Prevention and treatment of viral infections
US10603299B2 (en) 2016-06-02 2020-03-31 Steven Baranowitz Prevention and treatment of viral infections
CN106674170B (zh) * 2016-12-30 2019-03-15 国家海洋局第三海洋研究所 三种苯酚类衍生物的制备方法及其在制备抗hiv药物中的应用

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5542995B2 (es) * 1972-02-24 1980-11-04
US3825571A (en) * 1971-07-31 1974-07-23 Chugai Pharmaceutical Co Ltd Mycophenolic acid derivatives
JPS5529994B2 (es) * 1972-03-02 1980-08-07
US4686234A (en) * 1985-11-27 1987-08-11 Syntex (U.S.A) Inc. Mycophenolic acid derivatives in the treatment of inflammatory diseases, in particular rheumatoid arthritis
US4725622A (en) * 1986-01-23 1988-02-16 Syntex (U.S.A.) Inc. Mycophenolic acid derivatives in the treatment of rheumatoid arthritis
US4959387A (en) * 1986-01-23 1990-09-25 Syntex (U.S.A.) Inc. Mycophenolic acid derivatives in the treatment of rheumatoid arthritis
US4861776A (en) * 1987-01-30 1989-08-29 Syntex (U.S.A) Inc. Heterocyclic aminoalkyl esters of mycophenolic acid and derivatives thereof, compositions and use
US4748173A (en) * 1987-01-30 1988-05-31 Syntex (U.S.A.) Inc. Heterocyclic aminoalkyl esters of mycophenolic acid and derivatives thereof and pharmaceutical compositions
US4753935A (en) * 1987-01-30 1988-06-28 Syntex (U.S.A.) Inc. Morpholinoethylesters of mycophenolic acid and pharmaceutical compositions
US4727069A (en) * 1987-01-30 1988-02-23 Syntex (U.S.A.) Inc. Heterocyclic aminoalkyl esters of mycophenolic acid, derivatives thereof and pharmaceutical compositions
JPH0637486B2 (ja) * 1988-05-18 1994-05-18 三共株式会社 新規抗生物質フタレキシンおよびその製造法
CA2086642C (en) * 1992-01-09 2004-06-15 Randall E. Morris Method of treating hyperproliferative vascular disease
US5247083A (en) * 1992-07-10 1993-09-21 Syntex (U.S.A.) Inc. Direct esterification of mycophenolic acid

Also Published As

Publication number Publication date
ATE210127T1 (de) 2001-12-15
PT745075E (pt) 2002-05-31
BR9506835A (pt) 1997-10-14
HRP950071A2 (en) 1997-06-30
FI963221A0 (fi) 1996-08-16
WO1995022536A1 (en) 1995-08-24
SV1995000006A (es) 1996-09-30
CA2183533A1 (en) 1995-08-24
CN1141040A (zh) 1997-01-22
DE69524389T2 (de) 2002-08-29
PH31406A (en) 1998-10-29
US5444072A (en) 1995-08-22
TW369532B (en) 1999-09-11
HK1012634A1 (en) 1999-08-06
JPH09509172A (ja) 1997-09-16
ES2168359T3 (es) 2002-06-16
MY130110A (en) 2007-06-29
IL112667A0 (en) 1995-05-26
GT199500006A (es) 1996-08-10
UY23909A1 (es) 1995-03-06
AU1917095A (en) 1995-09-04
IS4265A (is) 1995-08-19
IL112667A (en) 2000-07-16
SI0745075T1 (en) 2002-06-30
CO4340735A1 (es) 1996-07-30
FI963221A (fi) 1996-10-16
EP0745075B1 (en) 2001-12-05
DE69524389D1 (de) 2002-01-17
ZA951295B (en) 1996-08-16
DK0745075T3 (da) 2002-03-04
UY25263A1 (es) 2001-01-31
EP0745075A1 (en) 1996-12-04
US5536747A (en) 1996-07-16

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Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed