ES2168359T3 - Acido micofenolico 6-sustituido y derivados con actividad inmunosupresora. - Google Patents

Acido micofenolico 6-sustituido y derivados con actividad inmunosupresora.

Info

Publication number
ES2168359T3
ES2168359T3 ES95911698T ES95911698T ES2168359T3 ES 2168359 T3 ES2168359 T3 ES 2168359T3 ES 95911698 T ES95911698 T ES 95911698T ES 95911698 T ES95911698 T ES 95911698T ES 2168359 T3 ES2168359 T3 ES 2168359T3
Authority
ES
Spain
Prior art keywords
derivatives
substituted
acid
immunosuppressing activity
micophenolic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95911698T
Other languages
English (en)
Inventor
Dean R Artis
Todd R Elworthy
Ronald C Hawley
David G Loughhead
David J Morgans Jr
Peter H Nelson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Application granted granted Critical
Publication of ES2168359T3 publication Critical patent/ES2168359T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LOS DERIVADOS 6-SUSTITUIDOS DE ACIDO MICOFENOLICO DESCUBIERTOS DE FORMULA (I) SON AGENTES TERAPEUTICOS VENTAJOSOS EN EL TRATAMIENTO DE ESTADOS DE ENFERMEDAD INDICADOS PARA ACIDO MICOFENOLICO Y/O MOFETIL MICOFENOLATO.
ES95911698T 1994-02-18 1995-02-16 Acido micofenolico 6-sustituido y derivados con actividad inmunosupresora. Expired - Lifetime ES2168359T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/198,725 US5444072A (en) 1994-02-18 1994-02-18 6-substituted mycophenolic acid and derivatives

Publications (1)

Publication Number Publication Date
ES2168359T3 true ES2168359T3 (es) 2002-06-16

Family

ID=22734546

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95911698T Expired - Lifetime ES2168359T3 (es) 1994-02-18 1995-02-16 Acido micofenolico 6-sustituido y derivados con actividad inmunosupresora.

Country Status (28)

Country Link
US (2) US5444072A (es)
EP (1) EP0745075B1 (es)
JP (1) JPH09509172A (es)
CN (1) CN1141040A (es)
AT (1) ATE210127T1 (es)
AU (1) AU1917095A (es)
BR (1) BR9506835A (es)
CA (1) CA2183533A1 (es)
CO (1) CO4340735A1 (es)
DE (1) DE69524389T2 (es)
DK (1) DK0745075T3 (es)
ES (1) ES2168359T3 (es)
FI (1) FI963221A (es)
GT (1) GT199500006A (es)
HK (1) HK1012634A1 (es)
HR (1) HRP950071A2 (es)
IL (1) IL112667A (es)
IS (1) IS4265A (es)
MY (1) MY130110A (es)
PE (1) PE23096A1 (es)
PH (1) PH31406A (es)
PT (1) PT745075E (es)
SI (1) SI0745075T1 (es)
SV (1) SV1995000006A (es)
TW (1) TW369532B (es)
UY (2) UY23909A1 (es)
WO (1) WO1995022536A1 (es)
ZA (1) ZA951295B (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6054472A (en) * 1996-04-23 2000-04-25 Vertex Pharmaceuticals, Incorporated Inhibitors of IMPDH enzyme
US5807876A (en) * 1996-04-23 1998-09-15 Vertex Pharmaceuticals Incorporated Inhibitors of IMPDH enzyme
SK286662B6 (sk) 1996-04-23 2009-03-05 Vertex Pharmaceuticals Incorporated Deriváty močoviny, farmaceutické prostriedky, ktoré ich obsahujú, a ich použitie ako inhibítorov aktivity IMPDH enzýmu
US6128582A (en) * 1996-04-30 2000-10-03 Vertex Pharmaceuticals Incorporated Molecules comprising an IMPDH-like binding pocket and encoded data storage medium capable of graphically displaying them
EP1366766A1 (en) * 1997-03-14 2003-12-03 Vertex Pharmaceuticals Incorporated Inhibitors of IMPDH enzyme
ES2201452T3 (es) * 1997-03-14 2004-03-16 Vertex Pharmaceuticals Incorporated Inhibidores de la enzima impdh.
US5932600A (en) * 1997-03-14 1999-08-03 Vertex Pharmaceuticals Incorporated Inhibitors of IMPDH enzyme
WO2000015210A2 (en) * 1998-09-14 2000-03-23 Vertex Pharmaceuticals Incorporated Use of mycophenol acid and its derivatives for the treatment of virus diseases
US6596747B2 (en) 1998-10-29 2003-07-22 Bristol-Myers Squibb Company Compounds derived from an amine nucleus and pharmaceutical compositions comprising same
WO2000026197A1 (en) * 1998-10-29 2000-05-11 Bristol-Myers Squibb Company Novel inhibitors of impdh enzyme
WO2000025780A1 (en) 1998-10-29 2000-05-11 Bristol-Myers Squibb Company Compounds derived from an amine nucleus that are inhibitors of impdh enzyme
US6420403B1 (en) 1998-10-29 2002-07-16 Edwin J. Iwanowicz Inhibitors of IMPDH enzyme
US6514979B1 (en) 1999-03-03 2003-02-04 University Of Maryland Biotechnology Institute Synergistic combinations of guanosine analog reverse transcriptase inhibitors and inosine monophosphate dehydrogenese inhibitors and uses therefor
EP1964561A1 (en) 1999-03-19 2008-09-03 Vertex Pharmaceuticals Incorporated Inhibitors of IMPDH enzyme
US6107052A (en) * 1999-06-09 2000-08-22 Roche Diagnostics Corporation Enzymatic measurement of mycophenolic acid
US6811998B2 (en) 1999-06-25 2004-11-02 Roche Diagnostics Operations, Inc. Conjugates of uncompetitive inhibitors of inosine monophosphate dehydrogenase
ATE248835T1 (de) 1999-06-25 2003-09-15 Vertex Pharma Prodrugs von impdh-inhibierenden carbamaten
EP1276739A2 (en) * 2000-04-24 2003-01-22 Bristol-Myers Squibb Company Heterocycles that are inhibitors of impdh enzyme
US7179791B2 (en) * 2001-01-11 2007-02-20 Duke University Inhibiting GS-FDH to modulate NO bioactivity
WO2003035066A1 (en) * 2001-10-23 2003-05-01 Celltech R & D Limited 2-aminoquinolone derivatives for use as impdh inhibitors
TW200301698A (en) * 2001-12-21 2003-07-16 Bristol Myers Squibb Co Acridone inhibitors of IMPDH enzyme
EP2181704B1 (en) 2002-12-30 2015-05-06 Angiotech International Ag Drug delivery from rapid gelling polymer composition
US20050187170A1 (en) * 2003-06-16 2005-08-25 Biocryst Pharmaceuticals, Inc. Enhancing the efficiency of RNA polymerase inhibitors by using inosine monophosphate dehydrogenase inhibitors
US7276362B2 (en) 2004-01-30 2007-10-02 Roche Diagnostics Operations, Inc. Recombinant histidine-tagged inosine monophosphate dehydrogenase polypeptides
CA2571710A1 (en) 2004-06-24 2006-11-02 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
CN102952105A (zh) * 2011-08-26 2013-03-06 中国科学院上海药物研究所 一类霉酚酸衍生物、其制备方法和用途
CN104597238B (zh) * 2015-01-27 2016-08-17 苏州博源医疗科技有限公司 一种霉酚酸均相酶免疫检测试剂及其制备和检测方法
CA3026241A1 (en) 2016-06-02 2017-12-07 Steven Baranowitz Prevention and treatment of viral infections
US12011429B2 (en) 2016-06-02 2024-06-18 Steven Baranowitz Prevention and treatment of viral infections
US10603299B2 (en) 2016-06-02 2020-03-31 Steven Baranowitz Prevention and treatment of viral infections
CN106674170B (zh) * 2016-12-30 2019-03-15 国家海洋局第三海洋研究所 三种苯酚类衍生物的制备方法及其在制备抗hiv药物中的应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3825571A (en) * 1971-07-31 1974-07-23 Chugai Pharmaceutical Co Ltd Mycophenolic acid derivatives
JPS5542995B2 (es) * 1972-02-24 1980-11-04
JPS5529994B2 (es) * 1972-03-02 1980-08-07
US4686234A (en) * 1985-11-27 1987-08-11 Syntex (U.S.A) Inc. Mycophenolic acid derivatives in the treatment of inflammatory diseases, in particular rheumatoid arthritis
US4725622A (en) * 1986-01-23 1988-02-16 Syntex (U.S.A.) Inc. Mycophenolic acid derivatives in the treatment of rheumatoid arthritis
US4959387A (en) * 1986-01-23 1990-09-25 Syntex (U.S.A.) Inc. Mycophenolic acid derivatives in the treatment of rheumatoid arthritis
US4753935A (en) * 1987-01-30 1988-06-28 Syntex (U.S.A.) Inc. Morpholinoethylesters of mycophenolic acid and pharmaceutical compositions
US4727069A (en) * 1987-01-30 1988-02-23 Syntex (U.S.A.) Inc. Heterocyclic aminoalkyl esters of mycophenolic acid, derivatives thereof and pharmaceutical compositions
US4748173A (en) * 1987-01-30 1988-05-31 Syntex (U.S.A.) Inc. Heterocyclic aminoalkyl esters of mycophenolic acid and derivatives thereof and pharmaceutical compositions
US4861776A (en) * 1987-01-30 1989-08-29 Syntex (U.S.A) Inc. Heterocyclic aminoalkyl esters of mycophenolic acid and derivatives thereof, compositions and use
JPH0637486B2 (ja) * 1988-05-18 1994-05-18 三共株式会社 新規抗生物質フタレキシンおよびその製造法
CA2086642C (en) * 1992-01-09 2004-06-15 Randall E. Morris Method of treating hyperproliferative vascular disease
US5247083A (en) * 1992-07-10 1993-09-21 Syntex (U.S.A.) Inc. Direct esterification of mycophenolic acid

Also Published As

Publication number Publication date
HRP950071A2 (en) 1997-06-30
PT745075E (pt) 2002-05-31
IL112667A (en) 2000-07-16
DE69524389D1 (de) 2002-01-17
SV1995000006A (es) 1996-09-30
JPH09509172A (ja) 1997-09-16
IS4265A (is) 1995-08-19
UY25263A1 (es) 2001-01-31
AU1917095A (en) 1995-09-04
DE69524389T2 (de) 2002-08-29
DK0745075T3 (da) 2002-03-04
TW369532B (en) 1999-09-11
UY23909A1 (es) 1995-03-06
PE23096A1 (es) 1996-06-04
EP0745075A1 (en) 1996-12-04
IL112667A0 (en) 1995-05-26
FI963221A (fi) 1996-10-16
FI963221A0 (fi) 1996-08-16
US5536747A (en) 1996-07-16
PH31406A (en) 1998-10-29
CA2183533A1 (en) 1995-08-24
EP0745075B1 (en) 2001-12-05
MY130110A (en) 2007-06-29
US5444072A (en) 1995-08-22
BR9506835A (pt) 1997-10-14
HK1012634A1 (en) 1999-08-06
CN1141040A (zh) 1997-01-22
ZA951295B (en) 1996-08-16
WO1995022536A1 (en) 1995-08-24
SI0745075T1 (en) 2002-06-30
ATE210127T1 (de) 2001-12-15
GT199500006A (es) 1996-08-10
CO4340735A1 (es) 1996-07-30

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