UY25263A1 - 6-derivados sustitutivos del ácido micofenólico.- - Google Patents

6-derivados sustitutivos del ácido micofenólico.-

Info

Publication number
UY25263A1
UY25263A1 UY25263A UY25263A UY25263A1 UY 25263 A1 UY25263 A1 UY 25263A1 UY 25263 A UY25263 A UY 25263A UY 25263 A UY25263 A UY 25263A UY 25263 A1 UY25263 A1 UY 25263A1
Authority
UY
Uruguay
Prior art keywords
mycophenolic acid
derivatives
substitutes
derivatives substitutes
treatment
Prior art date
Application number
UY25263A
Other languages
English (en)
Inventor
Mario F Zertuche
Robert J Weikert
David B Samith
John W Patterson Jr
David J Morgans Jr
Dean R Artris
Alicia C Garcia
Ronald C Hawley
Francisco X T Murra
Fidencio F Andrade
Ann Marie Waltos
Eric B Sjogren
Peter H Nelson
David G Loughhead
Todd R Elworthy
Teresa Martin
Maria Hernandez
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of UY25263A1 publication Critical patent/UY25263A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Un aspecto del actual invento concierne a los derivados del ácido micofenólico, por ejemplo los compuestos de la fórmula (A). En otro aspecto, el invento describe un compuesto farmacéutico que contiene una cantidad terapéuticamente efectiva del compuesto de la fórmula a o una sal farmacéuticamente aceptable mezclada con por lo menos un excipiente farmacéuticamente aceptable. En otro aspecto, el invento presenta un método para el tratamiento de desórdenes inmunológicos, inflamatorios, tumorales, proliferativos, virales y soriáticos, en un mamífero. El compuestos de fórmula A donde R1 es HoC(O)R10, con R10 es alquilo inferior , arilo o NH-arilo; R2 es alquilo inferior, cicloalquilo, vinilo; Z es una cadena lateral seleccionalo de las fórmulas por ejemplo ZA donde Z1 es H, aquilo inferior, halo o CF3; Z2 es H,alquilo inferior, alcoxi inferior, arilo; Z3 es H, alquilo inferior, alquenilo, alcoxi; Z4 es H,alcoxi interior,haluro o fenilo; G es OH, tioalquilo inferior, etc
UY25263A 1994-02-18 1998-11-23 6-derivados sustitutivos del ácido micofenólico.- UY25263A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/198,725 US5444072A (en) 1994-02-18 1994-02-18 6-substituted mycophenolic acid and derivatives

Publications (1)

Publication Number Publication Date
UY25263A1 true UY25263A1 (es) 2001-01-31

Family

ID=22734546

Family Applications (2)

Application Number Title Priority Date Filing Date
UY23909A UY23909A1 (es) 1994-02-18 1995-02-16 Procedimiento para la preparacion de 6- derivados sustitutivos del acido micofenolico
UY25263A UY25263A1 (es) 1994-02-18 1998-11-23 6-derivados sustitutivos del ácido micofenólico.-

Family Applications Before (1)

Application Number Title Priority Date Filing Date
UY23909A UY23909A1 (es) 1994-02-18 1995-02-16 Procedimiento para la preparacion de 6- derivados sustitutivos del acido micofenolico

Country Status (28)

Country Link
US (2) US5444072A (es)
EP (1) EP0745075B1 (es)
JP (1) JPH09509172A (es)
CN (1) CN1141040A (es)
AT (1) ATE210127T1 (es)
AU (1) AU1917095A (es)
BR (1) BR9506835A (es)
CA (1) CA2183533A1 (es)
CO (1) CO4340735A1 (es)
DE (1) DE69524389T2 (es)
DK (1) DK0745075T3 (es)
ES (1) ES2168359T3 (es)
FI (1) FI963221A (es)
GT (1) GT199500006A (es)
HK (1) HK1012634A1 (es)
HR (1) HRP950071A2 (es)
IL (1) IL112667A (es)
IS (1) IS4265A (es)
MY (1) MY130110A (es)
PE (1) PE23096A1 (es)
PH (1) PH31406A (es)
PT (1) PT745075E (es)
SI (1) SI0745075T1 (es)
SV (1) SV1995000006A (es)
TW (1) TW369532B (es)
UY (2) UY23909A1 (es)
WO (1) WO1995022536A1 (es)
ZA (1) ZA951295B (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5807876A (en) 1996-04-23 1998-09-15 Vertex Pharmaceuticals Incorporated Inhibitors of IMPDH enzyme
US6054472A (en) * 1996-04-23 2000-04-25 Vertex Pharmaceuticals, Incorporated Inhibitors of IMPDH enzyme
SK286662B6 (sk) 1996-04-23 2009-03-05 Vertex Pharmaceuticals Incorporated Deriváty močoviny, farmaceutické prostriedky, ktoré ich obsahujú, a ich použitie ako inhibítorov aktivity IMPDH enzýmu
US6128582A (en) 1996-04-30 2000-10-03 Vertex Pharmaceuticals Incorporated Molecules comprising an IMPDH-like binding pocket and encoded data storage medium capable of graphically displaying them
CA2282398A1 (en) 1997-03-14 1998-09-17 Steven M. Ronkin Inhibitors of impdh enzyme
EP1366766A1 (en) * 1997-03-14 2003-12-03 Vertex Pharmaceuticals Incorporated Inhibitors of IMPDH enzyme
US5932600A (en) * 1997-03-14 1999-08-03 Vertex Pharmaceuticals Incorporated Inhibitors of IMPDH enzyme
WO2000015210A2 (en) * 1998-09-14 2000-03-23 Vertex Pharmaceuticals Incorporated Use of mycophenol acid and its derivatives for the treatment of virus diseases
JP2002528499A (ja) 1998-10-29 2002-09-03 ブリストル−マイヤーズ スクイブ カンパニー Ｉｍｐｄｈ酵素のインヒビターであるアミノ核誘導化合物
US6596747B2 (en) 1998-10-29 2003-07-22 Bristol-Myers Squibb Company Compounds derived from an amine nucleus and pharmaceutical compositions comprising same
AU1707700A (en) * 1998-10-29 2000-05-22 Bristol-Myers Squibb Company Novel inhibitors of impdh enzyme
US6420403B1 (en) 1998-10-29 2002-07-16 Edwin J. Iwanowicz Inhibitors of IMPDH enzyme
US6514979B1 (en) 1999-03-03 2003-02-04 University Of Maryland Biotechnology Institute Synergistic combinations of guanosine analog reverse transcriptase inhibitors and inosine monophosphate dehydrogenese inhibitors and uses therefor
EE200100492A (et) * 1999-03-19 2002-12-16 Vertex Pharmaceuticals Incorporated Ensüümi IMPDH inhibiitorid
US6107052A (en) * 1999-06-09 2000-08-22 Roche Diagnostics Corporation Enzymatic measurement of mycophenolic acid
US6811998B2 (en) 1999-06-25 2004-11-02 Roche Diagnostics Operations, Inc. Conjugates of uncompetitive inhibitors of inosine monophosphate dehydrogenase
EP1196414B1 (en) 1999-06-25 2003-09-03 Vertex Pharmaceuticals Incorporated Prodrugs of carbamate inhibitors of impdh
AU5553801A (en) * 2000-04-24 2001-11-07 Bristol Myers Squibb Co Heterocycles that are inhibitors of impdh enzyme
US7179791B2 (en) * 2001-01-11 2007-02-20 Duke University Inhibiting GS-FDH to modulate NO bioactivity
US20030105073A1 (en) * 2001-10-23 2003-06-05 Haughan Alan Findlay Quinolone derivatives
TW200301698A (en) * 2001-12-21 2003-07-16 Bristol Myers Squibb Co Acridone inhibitors of IMPDH enzyme
AU2003300076C1 (en) 2002-12-30 2010-03-04 Angiotech International Ag Drug delivery from rapid gelling polymer composition
US20050187170A1 (en) * 2003-06-16 2005-08-25 Biocryst Pharmaceuticals, Inc. Enhancing the efficiency of RNA polymerase inhibitors by using inosine monophosphate dehydrogenase inhibitors
US7276362B2 (en) 2004-01-30 2007-10-02 Roche Diagnostics Operations, Inc. Recombinant histidine-tagged inosine monophosphate dehydrogenase polypeptides
WO2006115509A2 (en) 2004-06-24 2006-11-02 Novartis Vaccines And Diagnostics Inc. Small molecule immunopotentiators and assays for their detection
CN102952105A (zh) * 2011-08-26 2013-03-06 中国科学院上海药物研究所 一类霉酚酸衍生物、其制备方法和用途
CN104597238B (zh) * 2015-01-27 2016-08-17 苏州博源医疗科技有限公司 一种霉酚酸均相酶免疫检测试剂及其制备和检测方法
US10603299B2 (en) 2016-06-02 2020-03-31 Steven Baranowitz Prevention and treatment of viral infections
WO2017210262A1 (en) 2016-06-02 2017-12-07 Steven Baranowitz Prevention and treatment of viral infections
US12011429B2 (en) 2016-06-02 2024-06-18 Steven Baranowitz Prevention and treatment of viral infections
CN106674170B (zh) * 2016-12-30 2019-03-15 国家海洋局第三海洋研究所 三种苯酚类衍生物的制备方法及其在制备抗hiv药物中的应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3825571A (en) * 1971-07-31 1974-07-23 Chugai Pharmaceutical Co Ltd Mycophenolic acid derivatives
JPS5542995B2 (es) * 1972-02-24 1980-11-04
JPS5529994B2 (es) * 1972-03-02 1980-08-07
US4686234A (en) * 1985-11-27 1987-08-11 Syntex (U.S.A) Inc. Mycophenolic acid derivatives in the treatment of inflammatory diseases, in particular rheumatoid arthritis
US4959387A (en) * 1986-01-23 1990-09-25 Syntex (U.S.A.) Inc. Mycophenolic acid derivatives in the treatment of rheumatoid arthritis
US4725622A (en) * 1986-01-23 1988-02-16 Syntex (U.S.A.) Inc. Mycophenolic acid derivatives in the treatment of rheumatoid arthritis
US4748173A (en) * 1987-01-30 1988-05-31 Syntex (U.S.A.) Inc. Heterocyclic aminoalkyl esters of mycophenolic acid and derivatives thereof and pharmaceutical compositions
US4727069A (en) * 1987-01-30 1988-02-23 Syntex (U.S.A.) Inc. Heterocyclic aminoalkyl esters of mycophenolic acid, derivatives thereof and pharmaceutical compositions
US4861776A (en) * 1987-01-30 1989-08-29 Syntex (U.S.A) Inc. Heterocyclic aminoalkyl esters of mycophenolic acid and derivatives thereof, compositions and use
US4753935A (en) * 1987-01-30 1988-06-28 Syntex (U.S.A.) Inc. Morpholinoethylesters of mycophenolic acid and pharmaceutical compositions
JPH0637486B2 (ja) * 1988-05-18 1994-05-18 三共株式会社 新規抗生物質フタレキシンおよびその製造法
CA2086642C (en) * 1992-01-09 2004-06-15 Randall E. Morris Method of treating hyperproliferative vascular disease
US5247083A (en) * 1992-07-10 1993-09-21 Syntex (U.S.A.) Inc. Direct esterification of mycophenolic acid

Also Published As

Publication number Publication date
US5444072A (en) 1995-08-22
ES2168359T3 (es) 2002-06-16
GT199500006A (es) 1996-08-10
CA2183533A1 (en) 1995-08-24
MY130110A (en) 2007-06-29
PT745075E (pt) 2002-05-31
PH31406A (en) 1998-10-29
DE69524389D1 (de) 2002-01-17
TW369532B (en) 1999-09-11
CN1141040A (zh) 1997-01-22
AU1917095A (en) 1995-09-04
HK1012634A1 (en) 1999-08-06
DK0745075T3 (da) 2002-03-04
JPH09509172A (ja) 1997-09-16
EP0745075B1 (en) 2001-12-05
ZA951295B (en) 1996-08-16
PE23096A1 (es) 1996-06-04
UY23909A1 (es) 1995-03-06
IS4265A (is) 1995-08-19
FI963221A (fi) 1996-10-16
EP0745075A1 (en) 1996-12-04
IL112667A0 (en) 1995-05-26
IL112667A (en) 2000-07-16
US5536747A (en) 1996-07-16
ATE210127T1 (de) 2001-12-15
BR9506835A (pt) 1997-10-14
HRP950071A2 (en) 1997-06-30
SI0745075T1 (en) 2002-06-30
WO1995022536A1 (en) 1995-08-24
FI963221A0 (fi) 1996-08-16
DE69524389T2 (de) 2002-08-29
CO4340735A1 (es) 1996-07-30
SV1995000006A (es) 1996-09-30

Similar Documents

Publication Publication Date Title
UY25263A1 (es) 6-derivados sustitutivos del ácido micofenólico.-
BR9506820A (pt) Derivados de 4-amino de ácido micofenólico
TW427986B (en) 4-amino 6-substituted mycophenolic acid and derivatives
CO4340732A1 (es) 4-amino-derivados del acido micofenolico 5-substituido
MX9603483A (es) Acido micofenolico 6-sustituido y derivados.

Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20121219