BR9506819A - Derivados de ácido micofenólico substituídos na posiçao 5 - Google Patents
Derivados de ácido micofenólico substituídos na posiçao 5Info
- Publication number
- BR9506819A BR9506819A BR9506819A BR9506819A BR9506819A BR 9506819 A BR9506819 A BR 9506819A BR 9506819 A BR9506819 A BR 9506819A BR 9506819 A BR9506819 A BR 9506819A BR 9506819 A BR9506819 A BR 9506819A
- Authority
- BR
- Brazil
- Prior art keywords
- mycophenolic acid
- acid derivatives
- derivatives substituted
- mycophenolic
- proliferative
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
- C07F9/65517—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Transplantation (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/198,749 US5493030A (en) | 1994-02-18 | 1994-02-18 | 5-substituted derivatives of mycophenolic acid |
| PCT/US1995/001787 WO1995022538A1 (en) | 1994-02-18 | 1995-02-16 | 5-substituted derivatives of mycophenolic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9506819A true BR9506819A (pt) | 1997-09-09 |
Family
ID=22734662
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9506819A BR9506819A (pt) | 1994-02-18 | 1995-02-16 | Derivados de ácido micofenólico substituídos na posiçao 5 |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US5493030A (pt) |
| EP (1) | EP0745073B1 (pt) |
| JP (1) | JPH09509174A (pt) |
| CN (1) | CN1141038A (pt) |
| AT (1) | ATE194608T1 (pt) |
| AU (1) | AU1875495A (pt) |
| BR (1) | BR9506819A (pt) |
| CA (1) | CA2183530A1 (pt) |
| CO (1) | CO4340734A1 (pt) |
| DE (1) | DE69517957T2 (pt) |
| DK (1) | DK0745073T3 (pt) |
| ES (1) | ES2149971T3 (pt) |
| FI (1) | FI963218A (pt) |
| GR (1) | GR3033864T3 (pt) |
| GT (1) | GT199500007A (pt) |
| HR (1) | HRP950070B1 (pt) |
| IL (2) | IL112665A (pt) |
| IS (1) | IS4264A (pt) |
| MX (1) | MX9603478A (pt) |
| MY (1) | MY112804A (pt) |
| PE (1) | PE22996A1 (pt) |
| PH (1) | PH31441A (pt) |
| PT (1) | PT745073E (pt) |
| SI (1) | SI0745073T1 (pt) |
| SV (1) | SV1995000007A (pt) |
| TW (1) | TW384288B (pt) |
| UY (2) | UY23910A1 (pt) |
| WO (1) | WO1995022538A1 (pt) |
| ZA (1) | ZA951299B (pt) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6514979B1 (en) | 1999-03-03 | 2003-02-04 | University Of Maryland Biotechnology Institute | Synergistic combinations of guanosine analog reverse transcriptase inhibitors and inosine monophosphate dehydrogenese inhibitors and uses therefor |
| US6811998B2 (en) * | 1999-06-25 | 2004-11-02 | Roche Diagnostics Operations, Inc. | Conjugates of uncompetitive inhibitors of inosine monophosphate dehydrogenase |
| US7214754B2 (en) * | 1999-12-13 | 2007-05-08 | Ppg Industries Ohio, Inc. | Polymerizable polyol (allyl carbonate) compositions |
| US7179791B2 (en) | 2001-01-11 | 2007-02-20 | Duke University | Inhibiting GS-FDH to modulate NO bioactivity |
| AU2003261354A1 (en) * | 2002-08-02 | 2004-02-23 | The Regents Of The University Of California | New uses for inhibitors of inosine monophosphate dehydrogenase |
| US20050261237A1 (en) * | 2003-04-25 | 2005-11-24 | Boojamra Constantine G | Nucleoside phosphonate analogs |
| WO2004096285A2 (en) * | 2003-04-25 | 2004-11-11 | Gilead Sciences, Inc. | Anti-infective phosphonate conjugates |
| US20090247488A1 (en) * | 2003-04-25 | 2009-10-01 | Carina Cannizzaro | Anti-inflammatory phosphonate compounds |
| US7452901B2 (en) * | 2003-04-25 | 2008-11-18 | Gilead Sciences, Inc. | Anti-cancer phosphonate analogs |
| CN101410120A (zh) * | 2003-04-25 | 2009-04-15 | 吉里德科学公司 | 抗炎的膦酸酯化合物 |
| US7432261B2 (en) * | 2003-04-25 | 2008-10-07 | Gilead Sciences, Inc. | Anti-inflammatory phosphonate compounds |
| KR20060022647A (ko) | 2003-04-25 | 2006-03-10 | 길리애드 사이언시즈, 인코포레이티드 | 키나아제 억제 포스포네이트 유사체 |
| US7407965B2 (en) * | 2003-04-25 | 2008-08-05 | Gilead Sciences, Inc. | Phosphonate analogs for treating metabolic diseases |
| US7427636B2 (en) * | 2003-04-25 | 2008-09-23 | Gilead Sciences, Inc. | Inosine monophosphate dehydrogenase inhibitory phosphonate compounds |
| WO2005002626A2 (en) | 2003-04-25 | 2005-01-13 | Gilead Sciences, Inc. | Therapeutic phosphonate compounds |
| PT1628685E (pt) | 2003-04-25 | 2011-03-16 | Gilead Sciences Inc | Análogos de fosfonatos antivirais |
| US7470724B2 (en) * | 2003-04-25 | 2008-12-30 | Gilead Sciences, Inc. | Phosphonate compounds having immuno-modulatory activity |
| US20050187170A1 (en) * | 2003-06-16 | 2005-08-25 | Biocryst Pharmaceuticals, Inc. | Enhancing the efficiency of RNA polymerase inhibitors by using inosine monophosphate dehydrogenase inhibitors |
| ATE402157T1 (de) * | 2003-09-11 | 2008-08-15 | Sandoz Ag | Verfahren zur herstellung von mycophenolatmofetil |
| WO2005044279A1 (en) * | 2003-10-24 | 2005-05-19 | Gilead Sciences, Inc. | Purine nucleoside phosphonate conjugates |
| WO2005044308A1 (en) * | 2003-10-24 | 2005-05-19 | Gilead Sciences, Inc. | Phosphonate analogs of antimetabolites |
| MXPA06006899A (es) * | 2003-12-22 | 2006-09-04 | Gilead Sciences Inc | Derivados de carbovir y abacavir 4'-sustituidos asi como compuestos relacionados con actividad antiviral de virus de inmunodeficiencia humana y virus de la hepatitis c. |
| US20050153990A1 (en) * | 2003-12-22 | 2005-07-14 | Watkins William J. | Phosphonate substituted kinase inhibitors |
| BRPI0418031A (pt) * | 2003-12-22 | 2007-04-17 | Gilead Sciences Inc | inibidores de quinase fosfonato-substituìdos |
| EP1768662A2 (en) | 2004-06-24 | 2007-04-04 | Novartis Vaccines and Diagnostics, Inc. | Small molecule immunopotentiators and assays for their detection |
| ME01945B (me) | 2004-07-27 | 2011-12-31 | Gilead Sciences Inc | Nukleozid-fosfonatni konjugati kao sredstva protiv hiv-a |
| AU2005299284A1 (en) * | 2004-10-26 | 2006-05-04 | Gilead Sciences, Inc. | Phosphonate derivatives of mycophenolic acid |
| WO2008033466A2 (en) * | 2006-09-14 | 2008-03-20 | Combinatorx (Singapore) Pre. Ltd. | Compositions and methods for treatment of viral diseases |
| CN101422424B (zh) * | 2007-10-31 | 2012-10-24 | 王世亮 | 霉酚酸类药物植入剂及其制备方法和应用 |
| CN102089318B (zh) * | 2008-07-08 | 2014-05-21 | 吉里德科学公司 | Hiv抑制剂化合物的盐 |
| US9492426B2 (en) * | 2011-09-21 | 2016-11-15 | The Texas A&M University System | Mycophenolic acid analogues as anti-tumor chemosensitizing agents |
| CN105271935B (zh) * | 2015-11-03 | 2017-06-30 | 陶祖岐 | 一种生活垃圾制成的装饰板和包装箱板 |
| CA3026241A1 (en) | 2016-06-02 | 2017-12-07 | Steven Baranowitz | Prevention and treatment of viral infections |
| US10603299B2 (en) | 2016-06-02 | 2020-03-31 | Steven Baranowitz | Prevention and treatment of viral infections |
| US10851125B2 (en) | 2017-08-01 | 2020-12-01 | Gilead Sciences, Inc. | Crystalline forms of ethyl ((S)-((((2R,5R)-5-(6-amino-9H-purin-9-yl)-4-fluoro-2,5-dihydrofuran-2-yl)oxy)methyl)(phenoxy)phosphoryl(-L-alaninate |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5542995B2 (pt) * | 1972-02-24 | 1980-11-04 | ||
| US3825571A (en) * | 1971-07-31 | 1974-07-23 | Chugai Pharmaceutical Co Ltd | Mycophenolic acid derivatives |
| JPS5529994B2 (pt) * | 1972-03-02 | 1980-08-07 | ||
| US4515956A (en) * | 1982-12-16 | 1985-05-07 | The Dow Chemical Company | Selective preparation of isomers and enantiomers of cyclopropane carboxylic acids |
| US4479005A (en) * | 1982-12-16 | 1984-10-23 | The Dow Chemical Company | Selective preparation of isomers and enantiomers of cyclopropane carboxylic acids |
| US4686234A (en) * | 1985-11-27 | 1987-08-11 | Syntex (U.S.A) Inc. | Mycophenolic acid derivatives in the treatment of inflammatory diseases, in particular rheumatoid arthritis |
| US4725622A (en) * | 1986-01-23 | 1988-02-16 | Syntex (U.S.A.) Inc. | Mycophenolic acid derivatives in the treatment of rheumatoid arthritis |
| US4959387A (en) * | 1986-01-23 | 1990-09-25 | Syntex (U.S.A.) Inc. | Mycophenolic acid derivatives in the treatment of rheumatoid arthritis |
| US5231179A (en) * | 1986-01-27 | 1993-07-27 | Sumitomo Pharmaceuticals Company, Limited | Heterocyclic compounds and their production |
| US4748173A (en) * | 1987-01-30 | 1988-05-31 | Syntex (U.S.A.) Inc. | Heterocyclic aminoalkyl esters of mycophenolic acid and derivatives thereof and pharmaceutical compositions |
| US4753935A (en) * | 1987-01-30 | 1988-06-28 | Syntex (U.S.A.) Inc. | Morpholinoethylesters of mycophenolic acid and pharmaceutical compositions |
| US4727069A (en) * | 1987-01-30 | 1988-02-23 | Syntex (U.S.A.) Inc. | Heterocyclic aminoalkyl esters of mycophenolic acid, derivatives thereof and pharmaceutical compositions |
| US4861776A (en) * | 1987-01-30 | 1989-08-29 | Syntex (U.S.A) Inc. | Heterocyclic aminoalkyl esters of mycophenolic acid and derivatives thereof, compositions and use |
| JPH0637486B2 (ja) * | 1988-05-18 | 1994-05-18 | 三共株式会社 | 新規抗生物質フタレキシンおよびその製造法 |
| US4940797A (en) * | 1989-03-23 | 1990-07-10 | Merck & Co., Inc. | Process for synthesis of FK-506 C10-C18 intermediates |
| US5155228A (en) * | 1989-03-23 | 1992-10-13 | Merck & Co., Inc. | FK-506 C10-C18 process intermediates |
| US5068345A (en) * | 1989-10-30 | 1991-11-26 | Eastman Kodak Company | Oxazolidinone aldol adduct |
| US5247083A (en) * | 1992-07-10 | 1993-09-21 | Syntex (U.S.A.) Inc. | Direct esterification of mycophenolic acid |
-
1994
- 1994-02-18 US US08/198,749 patent/US5493030A/en not_active Expired - Lifetime
-
1995
- 1995-02-15 PH PH49980A patent/PH31441A/en unknown
- 1995-02-16 IL IL11266595A patent/IL112665A/xx not_active IP Right Cessation
- 1995-02-16 UY UY23910A patent/UY23910A1/es not_active IP Right Cessation
- 1995-02-16 SI SI9530434T patent/SI0745073T1/xx unknown
- 1995-02-16 TW TW084101398A patent/TW384288B/zh not_active IP Right Cessation
- 1995-02-16 IL IL12413995A patent/IL124139A/xx not_active IP Right Cessation
- 1995-02-16 CO CO95005930A patent/CO4340734A1/es unknown
- 1995-02-16 AU AU18754/95A patent/AU1875495A/en not_active Abandoned
- 1995-02-16 CA CA002183530A patent/CA2183530A1/en not_active Abandoned
- 1995-02-16 WO PCT/US1995/001787 patent/WO1995022538A1/en active IP Right Grant
- 1995-02-16 IS IS4264A patent/IS4264A/is unknown
- 1995-02-16 SV SV1995000007A patent/SV1995000007A/es not_active Application Discontinuation
- 1995-02-16 DE DE69517957T patent/DE69517957T2/de not_active Expired - Fee Related
- 1995-02-16 PE PE1995262077A patent/PE22996A1/es not_active Application Discontinuation
- 1995-02-16 ZA ZA951299A patent/ZA951299B/xx unknown
- 1995-02-16 BR BR9506819A patent/BR9506819A/pt active Search and Examination
- 1995-02-16 CN CN95191654A patent/CN1141038A/zh active Pending
- 1995-02-16 EP EP95910984A patent/EP0745073B1/en not_active Expired - Lifetime
- 1995-02-16 MY MYPI95000420A patent/MY112804A/en unknown
- 1995-02-16 PT PT95910984T patent/PT745073E/pt unknown
- 1995-02-16 JP JP7521868A patent/JPH09509174A/ja not_active Ceased
- 1995-02-16 DK DK95910984T patent/DK0745073T3/da active
- 1995-02-16 HR HR08/198,749 patent/HRP950070B1/xx not_active IP Right Cessation
- 1995-02-16 MX MX9603478A patent/MX9603478A/es unknown
- 1995-02-16 AT AT95910984T patent/ATE194608T1/de not_active IP Right Cessation
- 1995-02-16 ES ES95910984T patent/ES2149971T3/es not_active Expired - Lifetime
- 1995-02-17 GT GT199500007A patent/GT199500007A/es unknown
- 1995-06-06 US US08/483,042 patent/US5633279A/en not_active Expired - Lifetime
-
1996
- 1996-08-16 FI FI963218A patent/FI963218A/fi unknown
-
1998
- 1998-11-23 UY UY25262A patent/UY25262A1/es not_active Application Discontinuation
-
2000
- 2000-07-13 GR GR20000401101T patent/GR3033864T3/el not_active IP Right Cessation
Also Published As
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| Publication | Publication Date | Title |
|---|---|---|
| BR9506819A (pt) | Derivados de ácido micofenólico substituídos na posiçao 5 | |
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| BR9506820A (pt) | Derivados de 4-amino de ácido micofenólico | |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB36 | Technical and formal requirements: requirement - article 36 of industrial property law | ||
| HJEG | Technical examination (opinion): technical examination (opinion) related to article 229 of industrial property law | ||
| FF | Decision: intention to grant |