ATE402157T1 - Verfahren zur herstellung von mycophenolatmofetil - Google Patents
Verfahren zur herstellung von mycophenolatmofetilInfo
- Publication number
- ATE402157T1 ATE402157T1 AT04765061T AT04765061T ATE402157T1 AT E402157 T1 ATE402157 T1 AT E402157T1 AT 04765061 T AT04765061 T AT 04765061T AT 04765061 T AT04765061 T AT 04765061T AT E402157 T1 ATE402157 T1 AT E402157T1
- Authority
- AT
- Austria
- Prior art keywords
- mycophenolate mofetil
- products
- relates
- producing
- dimeric
- Prior art date
Links
- RTGDFNSFWBGLEC-SYZQJQIISA-N mycophenolate mofetil Chemical compound COC1=C(C)C=2COC(=O)C=2C(O)=C1C\C=C(/C)CCC(=O)OCCN1CCOCC1 RTGDFNSFWBGLEC-SYZQJQIISA-N 0.000 title abstract 4
- 229960004866 mycophenolate mofetil Drugs 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000006227 byproduct Substances 0.000 abstract 2
- KKFDCBRMNNSAAW-UHFFFAOYSA-N 2-(morpholin-4-yl)ethanol Chemical compound OCCN1CCOCC1 KKFDCBRMNNSAAW-UHFFFAOYSA-N 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- HPNSFSBZBAHARI-RUDMXATFSA-N mycophenolic acid Chemical class OC1=C(C\C=C(/C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-RUDMXATFSA-N 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000467 secondary amino group Chemical class [H]N([*:1])[*:2] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT14332003 | 2003-09-11 | ||
| AT20292003 | 2003-12-17 | ||
| AT20302003 | 2003-12-17 | ||
| PCT/EP2004/010134 WO2005023791A2 (en) | 2003-09-11 | 2004-09-10 | Process for the production of mycophenolate mofetil |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE402157T1 true ATE402157T1 (de) | 2008-08-15 |
Family
ID=34279103
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04765061T ATE402157T1 (de) | 2003-09-11 | 2004-09-10 | Verfahren zur herstellung von mycophenolatmofetil |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20070032483A1 (de) |
| EP (1) | EP1667987B1 (de) |
| AT (1) | ATE402157T1 (de) |
| CA (1) | CA2537958C (de) |
| DE (1) | DE602004015310D1 (de) |
| ES (1) | ES2308226T3 (de) |
| PL (1) | PL1667987T3 (de) |
| WO (1) | WO2005023791A2 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7683188B2 (en) * | 2004-04-26 | 2010-03-23 | TEVA Gyógyszergyár Zártkōrūen Mūkōdō Részvénytársaság | Process for preparation of mycophenolic acid and ester derivatives thereof |
| EP2032712B1 (de) * | 2006-06-29 | 2010-02-10 | Ivax Pharmaceuticals S.R.O. | Regulation der säuremetabolitproduktion |
| WO2008003637A2 (en) * | 2006-07-05 | 2008-01-10 | Dsm Ip Assets B.V. | Isolation and use of amine salts of mycophenolic acid |
| US20080188653A1 (en) | 2007-02-04 | 2008-08-07 | Formosa Laboratories, Inc. | Process for Preparation of Mycophenolate Mofetil |
| WO2008127663A1 (en) * | 2007-04-11 | 2008-10-23 | Teva Gyógyszergyár Zártköruen Muködo Részvénytársaság | Method for reducing impurity level in mycophenolic acid fermentation |
| WO2009040828A1 (en) * | 2007-09-25 | 2009-04-02 | Biocon Limited | A process for purification of mycophenolic acid |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1173942A (en) * | 1967-06-06 | 1969-12-10 | Bellon Labor Sa Roger | New 2,3-Dihydro-1,4-Benzoxazines |
| JPS5542995B2 (de) * | 1972-02-24 | 1980-11-04 | ||
| US3868454A (en) * | 1972-08-14 | 1975-02-25 | Lilly Co Eli | Psoriasis treatment with mycophenolic acid derivatives |
| US3880995A (en) * | 1973-05-14 | 1975-04-29 | Lilly Co Eli | Treatment of arthritis with mycophenolic acid and derivatives |
| US4686234A (en) * | 1985-11-27 | 1987-08-11 | Syntex (U.S.A) Inc. | Mycophenolic acid derivatives in the treatment of inflammatory diseases, in particular rheumatoid arthritis |
| US4727069A (en) * | 1987-01-30 | 1988-02-23 | Syntex (U.S.A.) Inc. | Heterocyclic aminoalkyl esters of mycophenolic acid, derivatives thereof and pharmaceutical compositions |
| US4748173A (en) * | 1987-01-30 | 1988-05-31 | Syntex (U.S.A.) Inc. | Heterocyclic aminoalkyl esters of mycophenolic acid and derivatives thereof and pharmaceutical compositions |
| US4753935A (en) * | 1987-01-30 | 1988-06-28 | Syntex (U.S.A.) Inc. | Morpholinoethylesters of mycophenolic acid and pharmaceutical compositions |
| US5247083A (en) * | 1992-07-10 | 1993-09-21 | Syntex (U.S.A.) Inc. | Direct esterification of mycophenolic acid |
| BR9407469A (pt) * | 1993-09-15 | 1996-11-12 | Syntex Inc | Micofenolato mofetil anidro cristalino e formulação intravenosa do mesmo |
| US5493030A (en) * | 1994-02-18 | 1996-02-20 | Syntex (U.S.A.) Inc. | 5-substituted derivatives of mycophenolic acid |
| IN188985B (de) * | 1998-12-09 | 2002-11-30 | Biocon Ltd | |
| CZ292123B6 (cs) * | 2001-06-08 | 2003-08-13 | Ivax Pharmaceuticals S.R.O. | Způsob přípravy mykofenolátu mofetilu |
| EP1539693B9 (de) * | 2002-06-19 | 2008-10-08 | Schering Corporation | Agonisten des cannabinoidrezeptors |
-
2004
- 2004-09-10 ES ES04765061T patent/ES2308226T3/es not_active Expired - Lifetime
- 2004-09-10 DE DE602004015310T patent/DE602004015310D1/de not_active Expired - Lifetime
- 2004-09-10 US US10/570,641 patent/US20070032483A1/en not_active Abandoned
- 2004-09-10 CA CA2537958A patent/CA2537958C/en not_active Expired - Fee Related
- 2004-09-10 AT AT04765061T patent/ATE402157T1/de not_active IP Right Cessation
- 2004-09-10 WO PCT/EP2004/010134 patent/WO2005023791A2/en not_active Ceased
- 2004-09-10 EP EP04765061A patent/EP1667987B1/de not_active Expired - Lifetime
- 2004-09-10 PL PL04765061T patent/PL1667987T3/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1667987B1 (de) | 2008-07-23 |
| US20070032483A1 (en) | 2007-02-08 |
| PL1667987T3 (pl) | 2009-01-30 |
| CA2537958C (en) | 2013-06-11 |
| WO2005023791A2 (en) | 2005-03-17 |
| WO2005023791A3 (en) | 2005-11-17 |
| CA2537958A1 (en) | 2005-03-17 |
| DE602004015310D1 (de) | 2008-09-04 |
| ES2308226T3 (es) | 2008-12-01 |
| EP1667987A2 (de) | 2006-06-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |