UY23910A1 - Procedimiento para la preparacion de 5- derivados sustitutivos del acido micofenolico - Google Patents
Procedimiento para la preparacion de 5- derivados sustitutivos del acido micofenolicoInfo
- Publication number
- UY23910A1 UY23910A1 UY23910A UY23910A UY23910A1 UY 23910 A1 UY23910 A1 UY 23910A1 UY 23910 A UY23910 A UY 23910A UY 23910 A UY23910 A UY 23910A UY 23910 A1 UY23910 A1 UY 23910A1
- Authority
- UY
- Uruguay
- Prior art keywords
- mycophenolic acid
- procedure
- preparation
- substitute derivatives
- derivatives
- Prior art date
Links
- HPNSFSBZBAHARI-RUDMXATFSA-N mycophenolic acid Chemical class OC1=C(C\C=C(/C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-RUDMXATFSA-N 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- HPNSFSBZBAHARI-UHFFFAOYSA-N micophenolic acid Natural products OC1=C(CC=C(C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-UHFFFAOYSA-N 0.000 abstract 2
- 229960000951 mycophenolic acid Drugs 0.000 abstract 2
- NIONDZDPPYHYKY-SNAWJCMRSA-N (2E)-hexenoic acid Chemical group CCC\C=C\C(O)=O NIONDZDPPYHYKY-SNAWJCMRSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- -1 immune Chemical compound 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- RTGDFNSFWBGLEC-SYZQJQIISA-N mycophenolate mofetil Chemical compound COC1=C(C)C=2COC(=O)C=2C(O)=C1C\C=C(/C)CCC(=O)OCCN1CCOCC1 RTGDFNSFWBGLEC-SYZQJQIISA-N 0.000 abstract 1
- 229960004866 mycophenolate mofetil Drugs 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 230000001185 psoriatic effect Effects 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
- C07F9/65517—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Se describe un proceso para la preparación de un compuesto de fórmula I (figura 1) donde R1 es hidrógeno o C(O)R10 donde R10 es alquilo inferior, arilo o NH-arilo; y Z se selecciona de, por ejemplo, la fórmula ZA (figura 2) donde Z13 es heteroarilo, entre otras posibilidades; Z3 o Z4 tomados juntos con el carbono al cual están uniodos forman cicloalquilo de 3 a 5 átomos de carbonos; o una sal farmaceuticamente aceptable, cuyo proceso comprende: (a) desprotegiendo un compuesto de Fórmula I'; (b) hidrolizando un compuesto de Fórmula I; (c) esterificando un compuesto de Fórmula I; (d) oxidando un compuesto de Fórmula I; (e) reduciendo un compuesto de Fórmula I'; (f) decarboxilando un compuesto de Fórmula I' (g) convirtiendo un compuesto libre de fórmula I con un reactivo en un solvente bajo una temperatura que se sabe es adecuada para la preparación de una sal, para formar una sal farmaceuticamente aceptable del compuesto de Fórmula I. Como ejemplo no limitante: (+) (E)-6-(1,3-dihidro-4-hidroxi-6-metoxi-7-metilo-3-oxoisobenzufurano-5-yl)-2,3,4-trimetil-4-acido hexonoico. Son agentes terapéuticos ventajosos en el tratamiento de enfermedades indicados para el ácido micofenólico y/o micofenolato mofetil, incluyendo inmunidad, inflamación, tumores, proliferantes, virosos o desórdenes psoriáticos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/198,749 US5493030A (en) | 1994-02-18 | 1994-02-18 | 5-substituted derivatives of mycophenolic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY23910A1 true UY23910A1 (es) | 1995-03-06 |
Family
ID=22734662
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY23910A UY23910A1 (es) | 1994-02-18 | 1995-02-16 | Procedimiento para la preparacion de 5- derivados sustitutivos del acido micofenolico |
| UY25262A UY25262A1 (es) | 1994-02-18 | 1998-11-23 | 5-derivados sustituidos del ácido micofenolico |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY25262A UY25262A1 (es) | 1994-02-18 | 1998-11-23 | 5-derivados sustituidos del ácido micofenolico |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US5493030A (es) |
| EP (1) | EP0745073B1 (es) |
| JP (1) | JPH09509174A (es) |
| CN (1) | CN1141038A (es) |
| AT (1) | ATE194608T1 (es) |
| AU (1) | AU1875495A (es) |
| BR (1) | BR9506819A (es) |
| CA (1) | CA2183530A1 (es) |
| CO (1) | CO4340734A1 (es) |
| DE (1) | DE69517957T2 (es) |
| DK (1) | DK0745073T3 (es) |
| ES (1) | ES2149971T3 (es) |
| FI (1) | FI963218A (es) |
| GR (1) | GR3033864T3 (es) |
| GT (1) | GT199500007A (es) |
| HR (1) | HRP950070B1 (es) |
| IL (2) | IL112665A (es) |
| IS (1) | IS4264A (es) |
| MX (1) | MX9603478A (es) |
| MY (1) | MY112804A (es) |
| PE (1) | PE22996A1 (es) |
| PH (1) | PH31441A (es) |
| PT (1) | PT745073E (es) |
| SI (1) | SI0745073T1 (es) |
| SV (1) | SV1995000007A (es) |
| TW (1) | TW384288B (es) |
| UY (2) | UY23910A1 (es) |
| WO (1) | WO1995022538A1 (es) |
| ZA (1) | ZA951299B (es) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6514979B1 (en) | 1999-03-03 | 2003-02-04 | University Of Maryland Biotechnology Institute | Synergistic combinations of guanosine analog reverse transcriptase inhibitors and inosine monophosphate dehydrogenese inhibitors and uses therefor |
| US6811998B2 (en) * | 1999-06-25 | 2004-11-02 | Roche Diagnostics Operations, Inc. | Conjugates of uncompetitive inhibitors of inosine monophosphate dehydrogenase |
| US7214754B2 (en) * | 1999-12-13 | 2007-05-08 | Ppg Industries Ohio, Inc. | Polymerizable polyol (allyl carbonate) compositions |
| US7179791B2 (en) | 2001-01-11 | 2007-02-20 | Duke University | Inhibiting GS-FDH to modulate NO bioactivity |
| US20040127435A1 (en) * | 2002-08-02 | 2004-07-01 | Regents Of The University Of California | Uses for inhibitors of inosine monophosphate dehydrogenase |
| WO2004096287A2 (en) * | 2003-04-25 | 2004-11-11 | Gilead Sciences, Inc. | Inosine monophosphate dehydrogenase inhibitory phosphonate compounds |
| JP2006524710A (ja) * | 2003-04-25 | 2006-11-02 | ギリアード サイエンシーズ， インコーポレイテッド | キナーゼインヒビターホスホネート抱合体 |
| CN101410120A (zh) * | 2003-04-25 | 2009-04-15 | 吉里德科学公司 | 抗炎的膦酸酯化合物 |
| US20050261237A1 (en) * | 2003-04-25 | 2005-11-24 | Boojamra Constantine G | Nucleoside phosphonate analogs |
| US7470724B2 (en) * | 2003-04-25 | 2008-12-30 | Gilead Sciences, Inc. | Phosphonate compounds having immuno-modulatory activity |
| US7452901B2 (en) * | 2003-04-25 | 2008-11-18 | Gilead Sciences, Inc. | Anti-cancer phosphonate analogs |
| US20090247488A1 (en) * | 2003-04-25 | 2009-10-01 | Carina Cannizzaro | Anti-inflammatory phosphonate compounds |
| US7300924B2 (en) * | 2003-04-25 | 2007-11-27 | Gilead Sciences, Inc. | Anti-infective phosphonate analogs |
| WO2005002626A2 (en) | 2003-04-25 | 2005-01-13 | Gilead Sciences, Inc. | Therapeutic phosphonate compounds |
| US7432261B2 (en) * | 2003-04-25 | 2008-10-07 | Gilead Sciences, Inc. | Anti-inflammatory phosphonate compounds |
| DK1628685T3 (da) * | 2003-04-25 | 2011-03-21 | Gilead Sciences Inc | Antivirale phosphonatanaloge |
| US7407965B2 (en) * | 2003-04-25 | 2008-08-05 | Gilead Sciences, Inc. | Phosphonate analogs for treating metabolic diseases |
| US20050187170A1 (en) * | 2003-06-16 | 2005-08-25 | Biocryst Pharmaceuticals, Inc. | Enhancing the efficiency of RNA polymerase inhibitors by using inosine monophosphate dehydrogenase inhibitors |
| US20070032483A1 (en) * | 2003-09-11 | 2007-02-08 | Julia Greil | Process for the production of mycophenolate mofetil |
| WO2005044279A1 (en) * | 2003-10-24 | 2005-05-19 | Gilead Sciences, Inc. | Purine nucleoside phosphonate conjugates |
| WO2005044308A1 (en) * | 2003-10-24 | 2005-05-19 | Gilead Sciences, Inc. | Phosphonate analogs of antimetabolites |
| MXPA06006899A (es) * | 2003-12-22 | 2006-09-04 | Gilead Sciences Inc | Derivados de carbovir y abacavir 4'-sustituidos asi como compuestos relacionados con actividad antiviral de virus de inmunodeficiencia humana y virus de la hepatitis c. |
| US20070281907A1 (en) * | 2003-12-22 | 2007-12-06 | Watkins William J | Kinase Inhibitor Phosphonate Conjugates |
| US20050153990A1 (en) * | 2003-12-22 | 2005-07-14 | Watkins William J. | Phosphonate substituted kinase inhibitors |
| CA2571710A1 (en) | 2004-06-24 | 2006-11-02 | Nicholas Valiante | Small molecule immunopotentiators and assays for their detection |
| US7871991B2 (en) | 2004-07-27 | 2011-01-18 | Gilead Sciences, Inc. | Phosphonate analogs of HIV inhibitor compounds |
| CA2585353A1 (en) * | 2004-10-26 | 2006-05-04 | Gilead Sciences, Inc. | Phosphonate derivatives of mycophenolic acid |
| WO2008033466A2 (en) * | 2006-09-14 | 2008-03-20 | Combinatorx (Singapore) Pre. Ltd. | Compositions and methods for treatment of viral diseases |
| CN101422424B (zh) * | 2007-10-31 | 2012-10-24 | 王世亮 | 霉酚酸类药物植入剂及其制备方法和应用 |
| MX2011000306A (es) * | 2008-07-08 | 2011-03-15 | Gilead Sciences Inc | Sales de compuestos inhibidores de hiv. |
| WO2013044028A2 (en) * | 2011-09-21 | 2013-03-28 | Texas A&M University System | Mycophenolic acid analogues as anti-tumor chemosensitizing agents |
| CN105271935B (zh) * | 2015-11-03 | 2017-06-30 | 陶祖岐 | 一种生活垃圾制成的装饰板和包装箱板 |
| CA3026241A1 (en) | 2016-06-02 | 2017-12-07 | Steven Baranowitz | Prevention and treatment of viral infections |
| US10603299B2 (en) | 2016-06-02 | 2020-03-31 | Steven Baranowitz | Prevention and treatment of viral infections |
| EP3960740B1 (en) | 2017-08-01 | 2023-11-15 | Gilead Sciences, Inc. | Crystalline forms of ethyl ((s)-((((2r,5r)-5-(6-amino-9h-purin-9-yl)-4-fluoro-2,5-dihydrofuran-2-yl)oxy)methyl)(phenoxy)phosphoryl)-l-alaninate (gs-9131) vanillate for treating viral infections |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5542995B2 (es) * | 1972-02-24 | 1980-11-04 | ||
| US3825571A (en) * | 1971-07-31 | 1974-07-23 | Chugai Pharmaceutical Co Ltd | Mycophenolic acid derivatives |
| JPS5529994B2 (es) * | 1972-03-02 | 1980-08-07 | ||
| US4515956A (en) * | 1982-12-16 | 1985-05-07 | The Dow Chemical Company | Selective preparation of isomers and enantiomers of cyclopropane carboxylic acids |
| US4479005A (en) * | 1982-12-16 | 1984-10-23 | The Dow Chemical Company | Selective preparation of isomers and enantiomers of cyclopropane carboxylic acids |
| US4686234A (en) * | 1985-11-27 | 1987-08-11 | Syntex (U.S.A) Inc. | Mycophenolic acid derivatives in the treatment of inflammatory diseases, in particular rheumatoid arthritis |
| US4959387A (en) * | 1986-01-23 | 1990-09-25 | Syntex (U.S.A.) Inc. | Mycophenolic acid derivatives in the treatment of rheumatoid arthritis |
| US4725622A (en) * | 1986-01-23 | 1988-02-16 | Syntex (U.S.A.) Inc. | Mycophenolic acid derivatives in the treatment of rheumatoid arthritis |
| US5231179A (en) * | 1986-01-27 | 1993-07-27 | Sumitomo Pharmaceuticals Company, Limited | Heterocyclic compounds and their production |
| US4861776A (en) * | 1987-01-30 | 1989-08-29 | Syntex (U.S.A) Inc. | Heterocyclic aminoalkyl esters of mycophenolic acid and derivatives thereof, compositions and use |
| US4753935A (en) * | 1987-01-30 | 1988-06-28 | Syntex (U.S.A.) Inc. | Morpholinoethylesters of mycophenolic acid and pharmaceutical compositions |
| US4727069A (en) * | 1987-01-30 | 1988-02-23 | Syntex (U.S.A.) Inc. | Heterocyclic aminoalkyl esters of mycophenolic acid, derivatives thereof and pharmaceutical compositions |
| US4748173A (en) * | 1987-01-30 | 1988-05-31 | Syntex (U.S.A.) Inc. | Heterocyclic aminoalkyl esters of mycophenolic acid and derivatives thereof and pharmaceutical compositions |
| JPH0637486B2 (ja) * | 1988-05-18 | 1994-05-18 | 三共株式会社 | 新規抗生物質フタレキシンおよびその製造法 |
| US4940797A (en) * | 1989-03-23 | 1990-07-10 | Merck & Co., Inc. | Process for synthesis of FK-506 C10-C18 intermediates |
| US5155228A (en) * | 1989-03-23 | 1992-10-13 | Merck & Co., Inc. | FK-506 C10-C18 process intermediates |
| US5068345A (en) * | 1989-10-30 | 1991-11-26 | Eastman Kodak Company | Oxazolidinone aldol adduct |
| US5247083A (en) * | 1992-07-10 | 1993-09-21 | Syntex (U.S.A.) Inc. | Direct esterification of mycophenolic acid |
-
1994
- 1994-02-18 US US08/198,749 patent/US5493030A/en not_active Expired - Lifetime
-
1995
- 1995-02-15 PH PH49980A patent/PH31441A/en unknown
- 1995-02-16 UY UY23910A patent/UY23910A1/es not_active IP Right Cessation
- 1995-02-16 IS IS4264A patent/IS4264A/is unknown
- 1995-02-16 ES ES95910984T patent/ES2149971T3/es not_active Expired - Lifetime
- 1995-02-16 PT PT95910984T patent/PT745073E/pt unknown
- 1995-02-16 CA CA002183530A patent/CA2183530A1/en not_active Abandoned
- 1995-02-16 DK DK95910984T patent/DK0745073T3/da active
- 1995-02-16 BR BR9506819A patent/BR9506819A/pt active Search and Examination
- 1995-02-16 TW TW084101398A patent/TW384288B/zh not_active IP Right Cessation
- 1995-02-16 PE PE1995262077A patent/PE22996A1/es not_active Application Discontinuation
- 1995-02-16 HR HR08/198,749 patent/HRP950070B1/xx not_active IP Right Cessation
- 1995-02-16 MY MYPI95000420A patent/MY112804A/en unknown
- 1995-02-16 AU AU18754/95A patent/AU1875495A/en not_active Abandoned
- 1995-02-16 AT AT95910984T patent/ATE194608T1/de not_active IP Right Cessation
- 1995-02-16 EP EP95910984A patent/EP0745073B1/en not_active Expired - Lifetime
- 1995-02-16 CO CO95005930A patent/CO4340734A1/es unknown
- 1995-02-16 SV SV1995000007A patent/SV1995000007A/es not_active Application Discontinuation
- 1995-02-16 DE DE69517957T patent/DE69517957T2/de not_active Expired - Fee Related
- 1995-02-16 SI SI9530434T patent/SI0745073T1/xx unknown
- 1995-02-16 CN CN95191654A patent/CN1141038A/zh active Pending
- 1995-02-16 IL IL11266595A patent/IL112665A/xx not_active IP Right Cessation
- 1995-02-16 IL IL12413995A patent/IL124139A/xx not_active IP Right Cessation
- 1995-02-16 MX MX9603478A patent/MX9603478A/es unknown
- 1995-02-16 WO PCT/US1995/001787 patent/WO1995022538A1/en active IP Right Grant
- 1995-02-16 ZA ZA951299A patent/ZA951299B/xx unknown
- 1995-02-16 JP JP7521868A patent/JPH09509174A/ja not_active Ceased
- 1995-02-17 GT GT199500007A patent/GT199500007A/es unknown
- 1995-06-06 US US08/483,042 patent/US5633279A/en not_active Expired - Lifetime
-
1996
- 1996-08-16 FI FI963218A patent/FI963218A/fi unknown
-
1998
- 1998-11-23 UY UY25262A patent/UY25262A1/es not_active Application Discontinuation
-
2000
- 2000-07-13 GR GR20000401101T patent/GR3033864T3/el not_active IP Right Cessation
Also Published As
Similar Documents
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| UY23910A1 (es) | Procedimiento para la preparacion de 5- derivados sustitutivos del acido micofenolico | |
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| FI963219A0 (fi) | Mykofenolihapon 4-aminojohdannaiset, joilla on immunosuppressanttiaktiivisuutta | |
| CO4340732A1 (es) | 4-amino-derivados del acido micofenolico 5-substituido | |
| IL112668A0 (en) | 4-amino 6-substituted mycophenolic acid and derivatives thereof, their preparation and pharmaceutical compositions containing them | |
| IT8421753A0 (it) | Agenti terapeutici per il trattamento di disturbi cardiaci edella circolazione, delle dislipidemie e delle deficienze delle prestazioni muscolari, procedimento per la loro preparazione e relative composizioni farmaceutiche. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| VENC | Patent expired |
Effective date: 20150216 |