ATE210126T1 - 4-amino-6-substituierte mycophenolsäurederivate mit immunsuppressiver wirkung - Google Patents

4-amino-6-substituierte mycophenolsäurederivate mit immunsuppressiver wirkung

Info

Publication number
ATE210126T1
ATE210126T1 AT95909544T AT95909544T ATE210126T1 AT E210126 T1 ATE210126 T1 AT E210126T1 AT 95909544 T AT95909544 T AT 95909544T AT 95909544 T AT95909544 T AT 95909544T AT E210126 T1 ATE210126 T1 AT E210126T1
Authority
AT
Austria
Prior art keywords
mycophenolic acid
amino
acid derivatives
immunosupressive
effects
Prior art date
Application number
AT95909544T
Other languages
English (en)
Inventor
Dean R Artis
Todd R Elworthy
Ronald C Hawley
David G Loughhead
David J Morgans Jr
Peter H Nelson
John W Patterson Jr
Eric B Sjogren
David B Smith
Ann Marie Waltos
Robert J Weikert
Alicia C Garcia
Mario F Zertuche
Fidencio F Andrade
Maria T L Hernandez
Francisco X T Murra
Teresa A T Martin
Original Assignee
Syntex Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Llc filed Critical Syntex Llc
Application granted granted Critical
Publication of ATE210126T1 publication Critical patent/ATE210126T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
AT95909544T 1994-02-18 1995-02-16 4-amino-6-substituierte mycophenolsäurederivate mit immunsuppressiver wirkung ATE210126T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/198,741 US5525602A (en) 1994-02-18 1994-02-18 Method of using 4-amino 6-substituted mycophenolic acid and derivatives
PCT/US1995/001783 WO1995022534A1 (en) 1994-02-18 1995-02-16 4-amino 6-substituted mycophenolic acid and derivatives with immunosuppressive activity

Publications (1)

Publication Number Publication Date
ATE210126T1 true ATE210126T1 (de) 2001-12-15

Family

ID=22734615

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95909544T ATE210126T1 (de) 1994-02-18 1995-02-16 4-amino-6-substituierte mycophenolsäurederivate mit immunsuppressiver wirkung

Country Status (19)

Country Link
US (2) US5525602A (de)
EP (1) EP0745071B1 (de)
JP (1) JPH09509170A (de)
CN (1) CN1141632A (de)
AT (1) ATE210126T1 (de)
AU (1) AU1747295A (de)
BR (1) BR9506836A (de)
CA (1) CA2183532A1 (de)
CO (1) CO4340733A1 (de)
DE (1) DE69524388T2 (de)
DK (1) DK0745071T3 (de)
ES (1) ES2169124T3 (de)
FI (1) FI963222A (de)
IL (1) IL112668A (de)
MX (1) MX9603477A (de)
PT (1) PT745071E (de)
TW (1) TW427986B (de)
WO (1) WO1995022534A1 (de)
ZA (1) ZA951300B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19541578C2 (de) * 1995-11-08 1997-08-21 Koenig & Bauer Albert Ag Wendestange
US6514979B1 (en) 1999-03-03 2003-02-04 University Of Maryland Biotechnology Institute Synergistic combinations of guanosine analog reverse transcriptase inhibitors and inosine monophosphate dehydrogenese inhibitors and uses therefor
US6811998B2 (en) * 1999-06-25 2004-11-02 Roche Diagnostics Operations, Inc. Conjugates of uncompetitive inhibitors of inosine monophosphate dehydrogenase
US20050187170A1 (en) * 2003-06-16 2005-08-25 Biocryst Pharmaceuticals, Inc. Enhancing the efficiency of RNA polymerase inhibitors by using inosine monophosphate dehydrogenase inhibitors
EP1768662A2 (de) 2004-06-24 2007-04-04 Novartis Vaccines and Diagnostics, Inc. Immunstimulatoren kleiner moleküle und assays für deren nachweis
US10603299B2 (en) 2016-06-02 2020-03-31 Steven Baranowitz Prevention and treatment of viral infections
CA3026241A1 (en) 2016-06-02 2017-12-07 Steven Baranowitz Prevention and treatment of viral infections

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3825571A (en) * 1971-07-31 1974-07-23 Chugai Pharmaceutical Co Ltd Mycophenolic acid derivatives
JPS5542995B2 (de) * 1972-02-24 1980-11-04
JPS5529994B2 (de) * 1972-03-02 1980-08-07
US4686234A (en) * 1985-11-27 1987-08-11 Syntex (U.S.A) Inc. Mycophenolic acid derivatives in the treatment of inflammatory diseases, in particular rheumatoid arthritis
US4959387A (en) * 1986-01-23 1990-09-25 Syntex (U.S.A.) Inc. Mycophenolic acid derivatives in the treatment of rheumatoid arthritis
US4725622A (en) * 1986-01-23 1988-02-16 Syntex (U.S.A.) Inc. Mycophenolic acid derivatives in the treatment of rheumatoid arthritis
US4748173A (en) * 1987-01-30 1988-05-31 Syntex (U.S.A.) Inc. Heterocyclic aminoalkyl esters of mycophenolic acid and derivatives thereof and pharmaceutical compositions
US4861776A (en) * 1987-01-30 1989-08-29 Syntex (U.S.A) Inc. Heterocyclic aminoalkyl esters of mycophenolic acid and derivatives thereof, compositions and use
US4727069A (en) * 1987-01-30 1988-02-23 Syntex (U.S.A.) Inc. Heterocyclic aminoalkyl esters of mycophenolic acid, derivatives thereof and pharmaceutical compositions
US4753935A (en) * 1987-01-30 1988-06-28 Syntex (U.S.A.) Inc. Morpholinoethylesters of mycophenolic acid and pharmaceutical compositions
JPH0637486B2 (ja) * 1988-05-18 1994-05-18 三共株式会社 新規抗生物質フタレキシンおよびその製造法
US5247083A (en) * 1992-07-10 1993-09-21 Syntex (U.S.A.) Inc. Direct esterification of mycophenolic acid
US5380879A (en) * 1994-02-18 1995-01-10 Syntex (U.S.A.) Inc. Derivatives of mycophenolic acid

Also Published As

Publication number Publication date
JPH09509170A (ja) 1997-09-16
BR9506836A (pt) 1997-10-14
US5525602A (en) 1996-06-11
ZA951300B (en) 1996-08-16
DE69524388D1 (de) 2002-01-17
WO1995022534A1 (en) 1995-08-24
IL112668A (en) 1999-08-17
FI963222A0 (fi) 1996-08-16
CN1141632A (zh) 1997-01-29
ES2169124T3 (es) 2002-07-01
DK0745071T3 (da) 2002-04-02
EP0745071A1 (de) 1996-12-04
MX9603477A (es) 1997-12-31
CA2183532A1 (en) 1995-08-24
US5554612A (en) 1996-09-10
EP0745071B1 (de) 2001-12-05
FI963222A (fi) 1996-10-18
DE69524388T2 (de) 2002-08-14
TW427986B (en) 2001-04-01
AU1747295A (en) 1995-09-04
CO4340733A1 (es) 1996-07-30
PT745071E (pt) 2002-04-29
IL112668A0 (en) 1995-05-26

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BR9506820A (pt) Derivados de 4-amino de ácido micofenólico
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ATE210126T1 (de) 4-amino-6-substituierte mycophenolsäurederivate mit immunsuppressiver wirkung
DE69502380T2 (de) 4-aminoderivate von 5-substituierten mycophenolsäuren
MX9603483A (es) Acido micofenolico 6-sustituido y derivados.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee