PL3063275T3 - Terapeutyczne fuzje nukleaza-albumina i sposoby - Google Patents

Terapeutyczne fuzje nukleaza-albumina i sposoby

Info

Publication number
PL3063275T3
PL3063275T3 PL14802986T PL14802986T PL3063275T3 PL 3063275 T3 PL3063275 T3 PL 3063275T3 PL 14802986 T PL14802986 T PL 14802986T PL 14802986 T PL14802986 T PL 14802986T PL 3063275 T3 PL3063275 T3 PL 3063275T3
Authority
PL
Poland
Prior art keywords
methods
albumin fusions
therapeutic nuclease
nuclease
therapeutic
Prior art date
Application number
PL14802986T
Other languages
English (en)
Inventor
James Arthur Posada
Chris GABEL
Original Assignee
Resolve Therapeutics, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Resolve Therapeutics, Llc filed Critical Resolve Therapeutics, Llc
Publication of PL3063275T3 publication Critical patent/PL3063275T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases RNAses, DNAses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/21—Endodeoxyribonucleases producing 5'-phosphomonoesters (3.1.21)
    • C12Y301/21001—Deoxyribonuclease I (3.1.21.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/27—Endoribonucleases producing 3'-phosphomonoesters (3.1.27)
    • C12Y301/27005—Pancreatic ribonuclease (3.1.27.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
PL14802986T 2013-10-31 2014-10-31 Terapeutyczne fuzje nukleaza-albumina i sposoby PL3063275T3 (pl)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361898384P 2013-10-31 2013-10-31
US201361898393P 2013-10-31 2013-10-31
US201361898370P 2013-10-31 2013-10-31
EP14802986.1A EP3063275B1 (en) 2013-10-31 2014-10-31 Therapeutic nuclease-albumin fusions and methods
PCT/US2014/063572 WO2015066550A1 (en) 2013-10-31 2014-10-31 Therapeutic nuclease-albumin fusions and methods

Publications (1)

Publication Number Publication Date
PL3063275T3 true PL3063275T3 (pl) 2020-03-31

Family

ID=51982759

Family Applications (1)

Application Number Title Priority Date Filing Date
PL14802986T PL3063275T3 (pl) 2013-10-31 2014-10-31 Terapeutyczne fuzje nukleaza-albumina i sposoby

Country Status (8)

Country Link
US (2) US10988745B2 (pl)
EP (1) EP3063275B1 (pl)
DK (1) DK3063275T3 (pl)
ES (1) ES2759252T3 (pl)
HR (1) HRP20192080T1 (pl)
PL (1) PL3063275T3 (pl)
SI (1) SI3063275T1 (pl)
WO (2) WO2015066550A1 (pl)

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LT3460056T (lt) 2009-11-02 2020-12-28 University Of Washington Terapinės nukleazės kompozicijos ir būdai
CN113005148A (zh) 2013-01-16 2021-06-22 爱默蕾大学 Cas9-核酸复合物及其相关用途
DK3063275T3 (da) * 2013-10-31 2019-11-25 Resolve Therapeutics Llc Terapeutiske nuklease-albumin-fusioner og fremgangsmåder
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WO2017044424A1 (en) * 2015-09-08 2017-03-16 Theripion, Inc. Apoa-1 fusion polypeptides and related compositions and methods
RU2018146050A (ru) * 2016-05-27 2020-06-29 Эббви Байотерапьютикс Инк. Биспецифические связывающие белки, которые связывают иммуномодулирующий белок и опухолевый антиген
CA3029627A1 (en) * 2016-07-01 2018-01-04 Resolve Therapeutics, Llc Optimized binuclease fusions and methods
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CN110386984B (zh) * 2018-04-17 2022-04-22 杭州尚健生物技术有限公司 结合cd47蛋白的融合蛋白及其应用
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WO2020163264A1 (en) * 2019-02-04 2020-08-13 Neutrolis, Inc. Engineered human extracellular dnase enzymes for drug candidate selection
US11352613B2 (en) 2019-02-04 2022-06-07 Neutrolis, Inc. Engineered human extracellular DNASE enzymes
EP4041880A4 (en) * 2019-10-07 2023-08-30 Texas Tech University System MUTANT DNASE1L3 WITH IMPROVED SERUM HALF-LIFE
AU2021205976A1 (en) * 2020-01-11 2022-07-07 Yale University Compositions and methods for treating, ameliorating, and/or preventing diseases or disorders caused by or associated with DNAse1 and/or DNAse1L3 deficiency
US20230072226A1 (en) * 2020-02-20 2023-03-09 Neutrolis, Inc. Basic domain-deleted dnase1-like 3 and uses thereof
AU2021288567A1 (en) * 2020-06-08 2023-02-09 Yale University Compositions and methods for treating and/or preventing coagulopathy and/or sepsis in patients suffering from bacterial and/or viral infections
CN112480247B (zh) * 2020-11-10 2023-09-22 华通福源生物技术(北京)股份有限公司 抗人血清白蛋白单克隆抗体

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US20160251638A1 (en) 2016-09-01
WO2015066550A1 (en) 2015-05-07
US10988745B2 (en) 2021-04-27
ES2759252T3 (es) 2020-05-08
WO2015066557A1 (en) 2015-05-07
US20210355462A1 (en) 2021-11-18
EP3063275B1 (en) 2019-09-25
DK3063275T3 (da) 2019-11-25

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