PL3063275T3 - Terapeutyczne fuzje nukleaza-albumina i sposoby - Google Patents

Terapeutyczne fuzje nukleaza-albumina i sposoby

Info

Publication number
PL3063275T3
PL3063275T3 PL14802986T PL14802986T PL3063275T3 PL 3063275 T3 PL3063275 T3 PL 3063275T3 PL 14802986 T PL14802986 T PL 14802986T PL 14802986 T PL14802986 T PL 14802986T PL 3063275 T3 PL3063275 T3 PL 3063275T3
Authority
PL
Poland
Prior art keywords
methods
albumin fusions
therapeutic nuclease
nuclease
therapeutic
Prior art date
Application number
PL14802986T
Other languages
English (en)
Inventor
James Arthur Posada
Chris GABEL
Original Assignee
Resolve Therapeutics, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Resolve Therapeutics, Llc filed Critical Resolve Therapeutics, Llc
Publication of PL3063275T3 publication Critical patent/PL3063275T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/21—Endodeoxyribonucleases producing 5'-phosphomonoesters (3.1.21)
    • C12Y301/21001—Deoxyribonuclease I (3.1.21.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/27—Endoribonucleases producing 3'-phosphomonoesters (3.1.27)
    • C12Y301/27005—Pancreatic ribonuclease (3.1.27.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
PL14802986T 2013-10-31 2014-10-31 Terapeutyczne fuzje nukleaza-albumina i sposoby PL3063275T3 (pl)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361898393P 2013-10-31 2013-10-31
US201361898384P 2013-10-31 2013-10-31
US201361898370P 2013-10-31 2013-10-31
PCT/US2014/063572 WO2015066550A1 (en) 2013-10-31 2014-10-31 Therapeutic nuclease-albumin fusions and methods
EP14802986.1A EP3063275B1 (en) 2013-10-31 2014-10-31 Therapeutic nuclease-albumin fusions and methods

Publications (1)

Publication Number Publication Date
PL3063275T3 true PL3063275T3 (pl) 2020-03-31

Family

ID=51982759

Family Applications (1)

Application Number Title Priority Date Filing Date
PL14802986T PL3063275T3 (pl) 2013-10-31 2014-10-31 Terapeutyczne fuzje nukleaza-albumina i sposoby

Country Status (8)

Country Link
US (3) US10988745B2 (pl)
EP (1) EP3063275B1 (pl)
DK (1) DK3063275T3 (pl)
ES (1) ES2759252T3 (pl)
HR (1) HRP20192080T1 (pl)
PL (1) PL3063275T3 (pl)
SI (1) SI3063275T1 (pl)
WO (2) WO2015066557A1 (pl)

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AU2014207618A1 (en) 2013-01-16 2015-08-06 Emory University Cas9-nucleic acid complexes and uses related thereto
ES2759252T3 (es) * 2013-10-31 2020-05-08 Resolve Therapeutics Llc Fusiones y métodos terapéuticos de nucleasa-albúmina
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WO2020076817A1 (en) * 2018-10-08 2020-04-16 Neutrolis, Inc. Engineering of dnase enzymes for manufacturing and therapy
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AU2020204992A1 (en) * 2019-01-04 2021-07-15 Resolve Therapeutics, Llc Treatment of sjogren's disease with nuclease fusion proteins
WO2020163264A1 (en) * 2019-02-04 2020-08-13 Neutrolis, Inc. Engineered human extracellular dnase enzymes for drug candidate selection
US11352613B2 (en) 2019-02-04 2022-06-07 Neutrolis, Inc. Engineered human extracellular DNASE enzymes
EP4041880A4 (en) 2019-10-07 2023-08-30 Texas Tech University System MUTANT DNASE1L3 WITH IMPROVED SERUM HALF-LIFE
BR112022013173A2 (pt) * 2020-01-11 2022-09-13 Univ Yale Composições e métodos para tratar, melhorar e/ou prevenir doenças ou transtornos causados por ou associados com a deficiência de dnase1 e/ou dnase1l3
CA3172548A1 (en) * 2020-02-20 2021-08-26 Neutrolis, Inc. Basic domain-deleted dnase1-like 3 and uses thereof
AU2021288567A1 (en) * 2020-06-08 2023-02-09 Yale University Compositions and methods for treating and/or preventing coagulopathy and/or sepsis in patients suffering from bacterial and/or viral infections
CN112480247B (zh) * 2020-11-10 2023-09-22 华通福源生物技术(北京)股份有限公司 抗人血清白蛋白单克隆抗体

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US10988745B2 (en) 2021-04-27
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