CA2987766A1 - Implant placement and removal systems - Google Patents
Implant placement and removal systems Download PDFInfo
- Publication number
- CA2987766A1 CA2987766A1 CA2987766A CA2987766A CA2987766A1 CA 2987766 A1 CA2987766 A1 CA 2987766A1 CA 2987766 A CA2987766 A CA 2987766A CA 2987766 A CA2987766 A CA 2987766A CA 2987766 A1 CA2987766 A1 CA 2987766A1
- Authority
- CA
- Canada
- Prior art keywords
- placement
- implant
- guide
- skin
- cannula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000007943 implant Substances 0.000 title claims abstract description 316
- 238000000034 method Methods 0.000 claims abstract description 94
- 230000003204 osmotic effect Effects 0.000 claims description 93
- 238000012800 visualization Methods 0.000 claims description 52
- 238000002513 implantation Methods 0.000 claims description 40
- 229910001220 stainless steel Inorganic materials 0.000 claims description 15
- 239000000463 material Substances 0.000 claims description 10
- 239000000853 adhesive Substances 0.000 claims description 9
- 230000001070 adhesive effect Effects 0.000 claims description 9
- 230000000694 effects Effects 0.000 claims description 8
- 238000003825 pressing Methods 0.000 claims description 8
- 230000000007 visual effect Effects 0.000 claims description 8
- 238000004140 cleaning Methods 0.000 claims description 7
- 239000003589 local anesthetic agent Substances 0.000 claims description 4
- 238000002559 palpation Methods 0.000 claims 3
- 239000000902 placebo Substances 0.000 description 58
- 229940068196 placebo Drugs 0.000 description 58
- 210000001519 tissue Anatomy 0.000 description 49
- 238000003780 insertion Methods 0.000 description 41
- 230000037431 insertion Effects 0.000 description 41
- 108010011459 Exenatide Proteins 0.000 description 12
- 229960001519 exenatide Drugs 0.000 description 12
- 206010033675 panniculitis Diseases 0.000 description 12
- 210000004304 subcutaneous tissue Anatomy 0.000 description 12
- 206010033557 Palpitations Diseases 0.000 description 10
- 238000002604 ultrasonography Methods 0.000 description 10
- 238000009792 diffusion process Methods 0.000 description 9
- 238000012216 screening Methods 0.000 description 9
- 229910052751 metal Inorganic materials 0.000 description 8
- 239000002184 metal Substances 0.000 description 8
- 239000004033 plastic Substances 0.000 description 8
- 229920003023 plastic Polymers 0.000 description 8
- 238000011282 treatment Methods 0.000 description 8
- HTQBXNHDCUEHJF-XWLPCZSASA-N Exenatide Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 HTQBXNHDCUEHJF-XWLPCZSASA-N 0.000 description 7
- 206010012601 diabetes mellitus Diseases 0.000 description 7
- 229940079593 drug Drugs 0.000 description 7
- 239000003814 drug Substances 0.000 description 7
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 6
- 210000003811 finger Anatomy 0.000 description 6
- 229960004194 lidocaine Drugs 0.000 description 6
- 108090000765 processed proteins & peptides Proteins 0.000 description 6
- 210000003815 abdominal wall Anatomy 0.000 description 5
- 239000013543 active substance Substances 0.000 description 5
- JUFFVKRROAPVBI-PVOYSMBESA-N chembl1210015 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N[C@H]1[C@@H]([C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO[C@]3(O[C@@H](C[C@H](O)[C@H](O)CO)[C@H](NC(C)=O)[C@@H](O)C3)C(O)=O)O2)O)[C@@H](CO)O1)NC(C)=O)C(=O)NCC(=O)NCC(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 JUFFVKRROAPVBI-PVOYSMBESA-N 0.000 description 5
- 201000009104 prediabetes syndrome Diseases 0.000 description 5
- 210000003813 thumb Anatomy 0.000 description 5
- 208000034656 Contusions Diseases 0.000 description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
- 208000002705 Glucose Intolerance Diseases 0.000 description 4
- 210000001015 abdomen Anatomy 0.000 description 4
- 239000012790 adhesive layer Substances 0.000 description 4
- 239000008103 glucose Substances 0.000 description 4
- 230000023597 hemostasis Effects 0.000 description 4
- 229920001296 polysiloxane Polymers 0.000 description 4
- 230000003014 reinforcing effect Effects 0.000 description 4
- 239000005060 rubber Substances 0.000 description 4
- 230000003187 abdominal effect Effects 0.000 description 3
- 238000013461 design Methods 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 238000007920 subcutaneous administration Methods 0.000 description 3
- -1 sucrose) Chemical class 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 208000004476 Acute Coronary Syndrome Diseases 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 206010019280 Heart failures Diseases 0.000 description 2
- 229910000831 Steel Inorganic materials 0.000 description 2
- 229910001069 Ti alloy Inorganic materials 0.000 description 2
- 230000036528 appetite Effects 0.000 description 2
- 235000019789 appetite Nutrition 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Natural products OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 238000012790 confirmation Methods 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 230000007717 exclusion Effects 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- IXZISFNWUWKBOM-ARQDHWQXSA-N fructosamine Chemical compound NC[C@@]1(O)OC[C@@H](O)[C@@H](O)[C@@H]1O IXZISFNWUWKBOM-ARQDHWQXSA-N 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 description 2
- 230000036961 partial effect Effects 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 230000000291 postprandial effect Effects 0.000 description 2
- 230000002441 reversible effect Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 239000010959 steel Substances 0.000 description 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 238000011179 visual inspection Methods 0.000 description 2
- PXRKCOCTEMYUEG-UHFFFAOYSA-N 5-aminoisoindole-1,3-dione Chemical compound NC1=CC=C2C(=O)NC(=O)C2=C1 PXRKCOCTEMYUEG-UHFFFAOYSA-N 0.000 description 1
- 229910000838 Al alloy Inorganic materials 0.000 description 1
- 208000024827 Alzheimer disease Diseases 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 206010007559 Cardiac failure congestive Diseases 0.000 description 1
- 208000031229 Cardiomyopathies Diseases 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 description 1
- 208000008279 Dumping Syndrome Diseases 0.000 description 1
- 206010016654 Fibrosis Diseases 0.000 description 1
- 206010018429 Glucose tolerance impaired Diseases 0.000 description 1
- 241000725303 Human immunodeficiency virus Species 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010020919 Hypervolaemia Diseases 0.000 description 1
- 206010020997 Hypoglycaemia unawareness Diseases 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- 108010028554 LDL Cholesterol Proteins 0.000 description 1
- 206010024604 Lipoatrophy Diseases 0.000 description 1
- 208000001145 Metabolic Syndrome Diseases 0.000 description 1
- 206010029164 Nephrotic syndrome Diseases 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 208000026251 Opioid-Related disease Diseases 0.000 description 1
- 208000018737 Parkinson disease Diseases 0.000 description 1
- 208000018262 Peripheral vascular disease Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 208000032395 Post gastric surgery syndrome Diseases 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 208000001280 Prediabetic State Diseases 0.000 description 1
- 206010037423 Pulmonary oedema Diseases 0.000 description 1
- 208000001647 Renal Insufficiency Diseases 0.000 description 1
- 208000030934 Restrictive pulmonary disease Diseases 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 235000019577 caloric intake Nutrition 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 230000007211 cardiovascular event Effects 0.000 description 1
- 230000007213 cerebrovascular event Effects 0.000 description 1
- 229960003333 chlorhexidine gluconate Drugs 0.000 description 1
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 230000007882 cirrhosis Effects 0.000 description 1
- 208000019425 cirrhosis of liver Diseases 0.000 description 1
- 239000013066 combination product Substances 0.000 description 1
- 229940127555 combination product Drugs 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 239000003433 contraceptive agent Substances 0.000 description 1
- 230000002254 contraceptive effect Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000003292 diminished effect Effects 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 239000013583 drug formulation Substances 0.000 description 1
- 208000002296 eclampsia Diseases 0.000 description 1
- 230000001610 euglycemic effect Effects 0.000 description 1
- 210000003722 extracellular fluid Anatomy 0.000 description 1
- 210000001723 extracellular space Anatomy 0.000 description 1
- 229920002457 flexible plastic Polymers 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 235000012631 food intake Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 239000003193 general anesthetic agent Substances 0.000 description 1
- 208000004104 gestational diabetes Diseases 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000024924 glomerular filtration Effects 0.000 description 1
- 230000002641 glycemic effect Effects 0.000 description 1
- 239000002874 hemostatic agent Substances 0.000 description 1
- 230000003345 hyperglycaemic effect Effects 0.000 description 1
- 201000001421 hyperglycemia Diseases 0.000 description 1
- 208000003532 hypothyroidism Diseases 0.000 description 1
- 230000002989 hypothyroidism Effects 0.000 description 1
- 230000003100 immobilizing effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 208000017169 kidney disease Diseases 0.000 description 1
- 201000006370 kidney failure Diseases 0.000 description 1
- 208000001921 latent autoimmune diabetes in adults Diseases 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000002690 local anesthesia Methods 0.000 description 1
- 239000010721 machine oil Substances 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000002991 molded plastic Substances 0.000 description 1
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 229920006255 plastic film Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 201000010065 polycystic ovary syndrome Diseases 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 201000011461 pre-eclampsia Diseases 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 208000005333 pulmonary edema Diseases 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 230000035488 systolic blood pressure Effects 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000012780 transparent material Substances 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/34—Trocars; Puncturing needles
- A61B17/3468—Trocars; Puncturing needles for implanting or removing devices, e.g. prostheses, implants, seeds, wires
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/34—Trocars; Puncturing needles
- A61B17/3403—Needle locating or guiding means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/34—Trocars; Puncturing needles
- A61B17/3494—Trocars; Puncturing needles with safety means for protection against accidental cutting or pricking, e.g. limiting insertion depth, pressure sensors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/50—Instruments, other than pincettes or toothpicks, for removing foreign bodies from the human body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/0169—Exchanging a catheter while keeping the guidewire in place
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
- A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/28—Surgical forceps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/28—Surgical forceps
- A61B17/2812—Surgical forceps with a single pivotal connection
- A61B17/282—Jaws
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/28—Surgical forceps
- A61B17/2812—Surgical forceps with a single pivotal connection
- A61B17/2833—Locking means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/28—Surgical forceps
- A61B2017/2808—Clamp, e.g. towel clamp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/28—Surgical forceps
- A61B17/2812—Surgical forceps with a single pivotal connection
- A61B17/2833—Locking means
- A61B2017/2837—Locking means with a locking ratchet
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/28—Surgical forceps
- A61B17/2812—Surgical forceps with a single pivotal connection
- A61B17/2841—Handles
- A61B2017/2845—Handles with a spring pushing the handle back
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/34—Trocars; Puncturing needles
- A61B17/3403—Needle locating or guiding means
- A61B2017/3405—Needle locating or guiding means using mechanical guide means
- A61B2017/3407—Needle locating or guiding means using mechanical guide means including a base for support on the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/34—Trocars; Puncturing needles
- A61B2017/347—Locking means, e.g. for locking instrument in cannula
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/08—Accessories or related features not otherwise provided for
- A61B2090/0807—Indication means
- A61B2090/0811—Indication means for the position of a particular part of an instrument with respect to the rest of the instrument, e.g. position of the anvil of a stapling instrument
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M19/00—Local anaesthesia; Hypothermia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M2025/0177—Introducing, guiding, advancing, emplacing or holding catheters having external means for receiving guide wires, wires or stiffening members, e.g. loops, clamps or lateral tubes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0069—Devices for implanting pellets, e.g. markers or solid medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/42—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for desensitising skin, for protruding skin to facilitate piercing, or for locating point where body is to be pierced
- A61M5/425—Protruding skin to facilitate piercing, e.g. vacuum cylinders, vein immobilising means
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medical Informatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Pathology (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Biophysics (AREA)
- Pulmonology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Cardiology (AREA)
- Prostheses (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Surgical Instruments (AREA)
- Accommodation For Nursing Or Treatment Tables (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562170561P | 2015-06-03 | 2015-06-03 | |
| US62/170,561 | 2015-06-03 | ||
| US201562170994P | 2015-06-04 | 2015-06-04 | |
| US62/170,994 | 2015-06-04 | ||
| PCT/US2016/035602 WO2016196851A2 (en) | 2015-06-03 | 2016-06-02 | Implant placement and removal systems |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2987766A1 true CA2987766A1 (en) | 2016-12-08 |
Family
ID=57441940
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2987766A Pending CA2987766A1 (en) | 2015-06-03 | 2016-06-02 | Implant placement and removal systems |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US10925639B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP3302354B1 (cg-RX-API-DMAC7.html) |
| JP (3) | JP6993235B2 (cg-RX-API-DMAC7.html) |
| KR (2) | KR20240042548A (cg-RX-API-DMAC7.html) |
| CN (2) | CN113598842A (cg-RX-API-DMAC7.html) |
| AU (3) | AU2016270984B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2987766A1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2968262T3 (cg-RX-API-DMAC7.html) |
| MA (1) | MA44390A (cg-RX-API-DMAC7.html) |
| MX (2) | MX2017015504A (cg-RX-API-DMAC7.html) |
| RU (1) | RU2730996C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2016196851A2 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA201708200B (cg-RX-API-DMAC7.html) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
| KR101200728B1 (ko) | 2006-08-09 | 2012-11-13 | 인타르시아 세라퓨틱스 인코포레이티드 | 삼투성 전달 시스템 및 피스톤 조립체 |
| RU2440097C2 (ru) | 2007-04-23 | 2012-01-20 | Интарсия Терапьютикс, Инк. | Способ лечения диабета ii типа и ожирения, осмотическое устройство для доставки и способ его изготовления |
| CA2726861C (en) | 2008-02-13 | 2014-05-27 | Intarcia Therapeutics, Inc. | Devices, formulations, and methods for delivery of multiple beneficial agents |
| HRP20171801T1 (hr) | 2009-09-28 | 2017-12-29 | Intarcia Therapeutics, Inc. | Brzo uspostavljanje i/ili brzo završavanje uglavnom stabilne primjene lijeka |
| US20120208755A1 (en) | 2011-02-16 | 2012-08-16 | Intarcia Therapeutics, Inc. | Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers |
| US9764122B2 (en) | 2014-07-25 | 2017-09-19 | Warsaw Orthopedic, Inc. | Drug delivery device and methods having an occluding member |
| US9775978B2 (en) | 2014-07-25 | 2017-10-03 | Warsaw Orthopedic, Inc. | Drug delivery device and methods having a retaining member |
| US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
| US10076650B2 (en) | 2015-11-23 | 2018-09-18 | Warsaw Orthopedic, Inc. | Enhanced stylet for drug depot injector |
| RU2760007C2 (ru) | 2016-05-16 | 2021-11-22 | Интарсия Терапьютикс, Инк. | Полипептиды, селективные к рецепторам глюкагона, и способы их применения |
| USD840030S1 (en) * | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
| USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
| USD802755S1 (en) | 2016-06-23 | 2017-11-14 | Warsaw Orthopedic, Inc. | Drug pellet cartridge |
| US10434261B2 (en) | 2016-11-08 | 2019-10-08 | Warsaw Orthopedic, Inc. | Drug pellet delivery system and method |
| WO2018129058A1 (en) | 2017-01-03 | 2018-07-12 | Intarcia Therapeutics, Inc. | Methods comprising continuous administration of a glp-1 receptor agonist and co-adminstration of a drug |
| USD933219S1 (en) | 2018-07-13 | 2021-10-12 | Intarcia Therapeutics, Inc. | Implant removal tool and assembly |
| EP3870082A1 (en) * | 2018-10-28 | 2021-09-01 | Cardiac Pacemakers, Inc. | Implantable monitor introducer design features |
| US11883058B2 (en) * | 2019-03-26 | 2024-01-30 | Covidien Lp | Jaw members, end effector assemblies, and ultrasonic surgical instruments including the same |
| US20210085893A1 (en) * | 2019-09-25 | 2021-03-25 | Danielle T. Abramson | Device and methodology for preparing skin for self-injection |
| USD1022194S1 (en) * | 2019-10-04 | 2024-04-09 | Shukla Medical | Strike plate for a surgical instrument |
| RU2721875C1 (ru) * | 2019-11-13 | 2020-05-25 | Государственное бюджетное учреждение Санкт-Петербургский научно-исследовательский институт скорой помощи им. И.И. Джанелидзе | Способ удаления титановой пластины при рубцовых и язвенных изменениях кожи головы |
| GB202000807D0 (en) * | 2020-01-20 | 2020-03-04 | Removaid As | Method |
| US11849973B2 (en) | 2020-04-16 | 2023-12-26 | Russell David MOORE | Implant removal devices and methods |
| CN113796929B (zh) * | 2021-07-21 | 2024-01-30 | 上海益超医疗器械有限公司 | 一种超声外科执行设备 |
| US20230149635A1 (en) * | 2021-11-12 | 2023-05-18 | Lupin Inc. | Applicator for Implant Insertion |
| WO2023102155A1 (en) * | 2021-12-02 | 2023-06-08 | Eastern Virginia Medical School | Device for subdermal insertion of solid media |
| US20240115283A1 (en) * | 2022-10-05 | 2024-04-11 | Russell David MOORE | Implant removal devices and methods |
Family Cites Families (735)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR640907A (fr) | 1927-06-25 | 1928-07-24 | Limitateur de débit automatique | |
| US2168437A (en) | 1935-04-10 | 1939-08-08 | Kenneth O Buercklin | Injection device |
| US2110208A (en) | 1937-02-12 | 1938-03-08 | U S Standard Products Company | Antigen preparations |
| US2531724A (en) | 1948-09-20 | 1950-11-28 | Edmund D Cevasco | Infant bath mat |
| US3025991A (en) | 1960-05-23 | 1962-03-20 | Carron Products Co | Bottle stopper |
| NL280825A (cg-RX-API-DMAC7.html) | 1962-07-11 | |||
| GB1049104A (en) | 1963-05-11 | 1966-11-23 | Prodotti Antibiotici Spa | Pharmaceutical compositions for oral or parenteral administration comprising tetracycline antibiotics |
| US3122162A (en) | 1963-06-20 | 1964-02-25 | Asa D Sands | Flow control device |
| BE744162A (fr) | 1969-01-16 | 1970-06-15 | Fuji Photo Film Co Ltd | Procede d'encapsulage |
| US3632768A (en) | 1969-10-02 | 1972-01-04 | Upjohn Co | Therapeutic composition and method for treating infections with actinospectacin |
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| DE2010115A1 (de) | 1970-03-04 | 1971-09-16 | Farbenfabriken Bayer Ag, 5090 Leverkusen | Verfahren zur Herstellung von Mikrogranulaten |
| US3625214A (en) | 1970-05-18 | 1971-12-07 | Alza Corp | Drug-delivery device |
| US3732865A (en) | 1971-01-13 | 1973-05-15 | Alza Corp | Osmotic dispenser |
| US3995631A (en) | 1971-01-13 | 1976-12-07 | Alza Corporation | Osmotic dispenser with means for dispensing active agent responsive to osmotic gradient |
| US4034756A (en) | 1971-01-13 | 1977-07-12 | Alza Corporation | Osmotically driven fluid dispenser |
| US4211771A (en) | 1971-06-01 | 1980-07-08 | Robins Ronald K | Treatment of human viral diseases with 1-B-D-ribofuranosyl-1,2,4-triazole-3-carboxamide |
| JPS523342B2 (cg-RX-API-DMAC7.html) | 1972-01-26 | 1977-01-27 | ||
| BE795516A (fr) | 1972-02-17 | 1973-08-16 | Ciba Geigy | Preparations de peptides huileuses et injectables et procede pour leur preparation |
| US3797492A (en) | 1972-12-27 | 1974-03-19 | Alza Corp | Device for dispensing product with directional guidance member |
| US3995632A (en) | 1973-05-04 | 1976-12-07 | Alza Corporation | Osmotic dispenser |
| GB1413186A (en) | 1973-06-27 | 1975-11-12 | Toyo Jozo Kk | Process for encapsulation of medicaments |
| DE2528516A1 (de) | 1974-07-05 | 1976-01-22 | Sandoz Ag | Neue galenische zubereitung |
| JPS523653A (en) | 1975-06-27 | 1977-01-12 | Fuji Photo Film Co Ltd | Process for producing fine polymer particles |
| US3987790A (en) | 1975-10-01 | 1976-10-26 | Alza Corporation | Osmotically driven fluid dispenser |
| US4008719A (en) | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
| US4078060A (en) | 1976-05-10 | 1978-03-07 | Richardson-Merrell Inc. | Method of inducing an estrogenic response |
| US4111202A (en) | 1976-11-22 | 1978-09-05 | Alza Corporation | Osmotic system for the controlled and delivery of agent over time |
| US4111203A (en) | 1976-11-22 | 1978-09-05 | Alza Corporation | Osmotic system with means for improving delivery kinetics of system |
| US4111201A (en) | 1976-11-22 | 1978-09-05 | Alza Corporation | Osmotic system for delivering selected beneficial agents having varying degrees of solubility |
| US4203439A (en) | 1976-11-22 | 1980-05-20 | Alza Corporation | Osmotic system with volume amplifier for increasing amount of agent delivered therefrom |
| USD258837S (en) | 1977-10-17 | 1981-04-07 | Gambro Dialysatoren Gmbh And Co. Kg | Dialyzer cartridge |
| US4195636A (en) * | 1978-03-27 | 1980-04-01 | Behnke Robert C | Arm flesh injection site clamp |
| USD259458S (en) | 1978-06-09 | 1981-06-09 | Fuller Charles R | Support pad for an infant |
| US4243030A (en) | 1978-08-18 | 1981-01-06 | Massachusetts Institute Of Technology | Implantable programmed microinfusion apparatus |
| US4305927A (en) | 1979-02-05 | 1981-12-15 | Alza Corporation | Method for the management of intraocular pressure |
| US4373527B1 (en) | 1979-04-27 | 1995-06-27 | Univ Johns Hopkins | Implantable programmable medication infusion system |
| US4380234A (en) * | 1979-08-16 | 1983-04-19 | Baxter Travenol Laboratories, Inc. | Infusion needle attachment |
| US4310516A (en) | 1980-02-01 | 1982-01-12 | Block Drug Company Inc. | Cosmetic and pharmaceutical vehicle thickened with solid emulsifier |
| US4384975A (en) | 1980-06-13 | 1983-05-24 | Sandoz, Inc. | Process for preparation of microspheres |
| AU546785B2 (en) | 1980-07-23 | 1985-09-19 | Commonwealth Of Australia, The | Open-loop controlled infusion of diabetics |
| US4350271A (en) | 1980-08-22 | 1982-09-21 | Alza Corporation | Water absorbing fluid dispenser |
| US4376118A (en) | 1980-10-06 | 1983-03-08 | Miles Laboratories, Inc. | Stable nonaqueous solution of tetracycline salt |
| US4389330A (en) | 1980-10-06 | 1983-06-21 | Stolle Research And Development Corporation | Microencapsulation process |
| US4340054A (en) | 1980-12-29 | 1982-07-20 | Alza Corporation | Dispenser for delivering fluids and solids |
| US4444498A (en) | 1981-02-27 | 1984-04-24 | Bentley Laboratories | Apparatus and method for measuring blood oxygen saturation |
| US4455145A (en) | 1981-07-10 | 1984-06-19 | Alza Corporation | Dispensing device with internal drive |
| AU561343B2 (en) | 1981-10-19 | 1987-05-07 | Genentech Inc. | Human immune interferon by recombinant dna |
| EP0079143A3 (en) | 1981-10-20 | 1984-11-21 | Adnovum Ag | Pseudoplastic gel transfer |
| EP0080879B1 (en) | 1981-11-28 | 1986-10-01 | Sunstar Kabushiki Kaisha | Pharmaceutical composition containing interferon in stable state |
| US5004689A (en) | 1982-02-22 | 1991-04-02 | Biogen, Massachusetts | DNA sequences, recombinant DNA molecules and processes for producing human gamma interferon-like polypeptides in high yields |
| US4439196A (en) | 1982-03-18 | 1984-03-27 | Merck & Co., Inc. | Osmotic drug delivery system |
| US4455143A (en) | 1982-03-22 | 1984-06-19 | Alza Corporation | Osmotic device for dispensing two different medications |
| US6936694B1 (en) | 1982-05-06 | 2005-08-30 | Intermune, Inc. | Manufacture and expression of large structural genes |
| DE3220116A1 (de) | 1982-05-28 | 1983-12-01 | Dr. Karl Thomae Gmbh, 7950 Biberach | Mikrobiologisch hergestellte (alpha)- und ss-interferone, dna-sequenzen, die fuer diese interferone codieren, mikroorganismen, die diese genetische information enthalten, und verfahren zu ihrer herstellung |
| US4530840A (en) | 1982-07-29 | 1985-07-23 | The Stolle Research And Development Corporation | Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents |
| US4753651A (en) | 1982-08-30 | 1988-06-28 | Alza Corporation | Self-driven pump |
| US4966843A (en) | 1982-11-01 | 1990-10-30 | Cetus Corporation | Expression of interferon genes in Chinese hamster ovary cells |
| US4552561A (en) | 1982-12-23 | 1985-11-12 | Alza Corporation | Body mounted pump housing and pump assembly employing the same |
| US4673405A (en) | 1983-03-04 | 1987-06-16 | Alza Corporation | Osmotic system with instant drug availability |
| US4639244A (en) | 1983-05-03 | 1987-01-27 | Nabil I. Rizk | Implantable electrophoretic pump for ionic drugs and associated methods |
| US4783337A (en) | 1983-05-11 | 1988-11-08 | Alza Corporation | Osmotic system comprising plurality of members for dispensing drug |
| US4765989A (en) | 1983-05-11 | 1988-08-23 | Alza Corporation | Osmotic device for administering certain drugs |
| DE3320583A1 (de) | 1983-06-08 | 1984-12-13 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue galenische zubereitungsformen von oralen antidiabetika und verfahren zu ihrer herstellung |
| JPS6058915A (ja) | 1983-09-12 | 1985-04-05 | Fujisawa Pharmaceut Co Ltd | 薬物含有脂質小胞体製剤 |
| US4594108A (en) | 1983-09-19 | 1986-06-10 | The Dow Chemical Company | Highly pseudoplastic polymer solutions |
| US5385738A (en) | 1983-10-14 | 1995-01-31 | Sumitomo Pharmaceuticals Company, Ltd. | Sustained-release injection |
| US4840896A (en) | 1983-11-02 | 1989-06-20 | Integrated Genetics, Inc. | Heteropolymeric protein |
| US5639639A (en) | 1983-11-02 | 1997-06-17 | Genzyme Corporation | Recombinant heterodimeric human fertility hormones, and methods, cells, vectors and DNA for the production thereof |
| US4923805A (en) | 1983-11-02 | 1990-05-08 | Integrated Genetics, Inc. | Fsh |
| US4855238A (en) | 1983-12-16 | 1989-08-08 | Genentech, Inc. | Recombinant gamma interferons having enhanced stability and methods therefor |
| MX9203641A (es) | 1983-12-16 | 1992-07-01 | Genentech Inc | Interferones gamma recombinantes que poseen estabilidad mejorada y metodos biotecnologicos para su obtencion. |
| US4851228A (en) | 1984-06-20 | 1989-07-25 | Merck & Co., Inc. | Multiparticulate controlled porosity osmotic |
| US5231176A (en) | 1984-08-27 | 1993-07-27 | Genentech, Inc. | Distinct family DNA encoding of human leukocyte interferons |
| US5120832A (en) | 1984-08-27 | 1992-06-09 | Genentech, Inc. | Distinct family of human leukocyte interferons |
| US4927687A (en) | 1984-10-01 | 1990-05-22 | Biotek, Inc. | Sustained release transdermal drug delivery composition |
| US5411951A (en) | 1984-10-04 | 1995-05-02 | Monsanto Company | Prolonged release of biologically active somatotropin |
| IE58110B1 (en) | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
| FI90990C (fi) | 1984-12-18 | 1994-04-25 | Boehringer Ingelheim Int | Rekombinantti-DNA-molekyyli, transformoitu isäntäorganismi ja menetelmä interferonin valmistamiseksi |
| US4655462A (en) | 1985-01-07 | 1987-04-07 | Peter J. Balsells | Canted coiled spring and seal |
| JPS61189230A (ja) | 1985-02-19 | 1986-08-22 | Nippon Kayaku Co Ltd | エトポシド製剤 |
| US4609374A (en) | 1985-04-22 | 1986-09-02 | Alza Corporation | Osmotic device comprising means for governing initial time of agent release therefrom |
| US4885166A (en) | 1985-06-11 | 1989-12-05 | Ciba-Geigy Corporation | Hybrid interferons |
| US4845196A (en) | 1985-06-24 | 1989-07-04 | G. D. Searle & Co. | Modified interferon gammas |
| US4847079A (en) | 1985-07-29 | 1989-07-11 | Schering Corporation | Biologically stable interferon compositions comprising thimerosal |
| IE59361B1 (en) | 1986-01-24 | 1994-02-09 | Akzo Nv | Pharmaceutical preparation for obtaining a highly viscous hydrogel or suspension |
| DE3607835A1 (de) | 1986-03-10 | 1987-09-24 | Boehringer Ingelheim Int | Hybridinterferone, deren verwendung als arzneimittel und als zwischenprodukte zur herstellung von antikoerpern und deren verwendung sowie verfahren zu ihrer herstellung |
| US4865845A (en) | 1986-03-21 | 1989-09-12 | Alza Corporation | Release rate adjustment of osmotic or diffusional delivery devices |
| US4737437A (en) | 1986-03-27 | 1988-04-12 | East Shore Chemical Co. | Light sensitive diazo compound, composition and method of making the composition |
| US5614492A (en) | 1986-05-05 | 1997-03-25 | The General Hospital Corporation | Insulinotropic hormone GLP-1 (7-36) and uses thereof |
| US5120712A (en) | 1986-05-05 | 1992-06-09 | The General Hospital Corporation | Insulinotropic hormone |
| US7138486B2 (en) | 1986-05-05 | 2006-11-21 | The General Hospital Corporation | Insulinotropic hormone derivatives and uses thereof |
| US5118666A (en) | 1986-05-05 | 1992-06-02 | The General Hospital Corporation | Insulinotropic hormone |
| US6849708B1 (en) | 1986-05-05 | 2005-02-01 | The General Hospital Corporation | Insulinotropic hormone and uses thereof |
| US4755180A (en) | 1986-06-16 | 1988-07-05 | Alza Corporation | Dosage form comprising solubility regulating member |
| DE3636123A1 (de) | 1986-10-23 | 1988-05-05 | Rentschler Arzneimittel | Arzneizubereitungen zur oralen verabreichung, die als einzeldosis 10 bis 240 mg dihydropyridin enthalten |
| ZA878295B (en) | 1986-11-06 | 1988-05-03 | Amarillo Cell Culture Co. Inc. | Treatment of immuno-resistant disease |
| CA1320905C (en) | 1986-11-06 | 1993-08-03 | Joseph M. Cummins | Treatment of immuno-resistant disease |
| DE3642096A1 (de) | 1986-12-10 | 1988-06-16 | Boehringer Ingelheim Int | Pferde-(gamma)-interferon |
| US5371089A (en) | 1987-02-26 | 1994-12-06 | Senetek, Plc | Method and composition for ameliorating the adverse effects of aging |
| US5278151A (en) | 1987-04-02 | 1994-01-11 | Ocular Research Of Boston, Inc. | Dry eye treatment solution |
| JPH0720866B2 (ja) | 1987-05-15 | 1995-03-08 | 三生製薬株式会社 | エペリゾン又はトルペリゾン或いはそれらの塩類含有経皮適用製剤 |
| US4892778A (en) | 1987-05-27 | 1990-01-09 | Alza Corporation | Juxtaposed laminated arrangement |
| US4940465A (en) | 1987-05-27 | 1990-07-10 | Felix Theeuwes | Dispenser comprising displaceable matrix with solid state properties |
| US5023088A (en) | 1987-06-25 | 1991-06-11 | Alza Corporation | Multi-unit delivery system |
| US4874388A (en) | 1987-06-25 | 1989-10-17 | Alza Corporation | Multi-layer delivery system |
| US5938654A (en) | 1987-06-25 | 1999-08-17 | Alza Corporation | Osmotic device for delayed delivery of agent |
| US4915949A (en) | 1987-07-13 | 1990-04-10 | Alza Corporation | Dispenser with movable matrix comprising a plurality of tiny pills |
| EP0303306B1 (en) | 1987-08-08 | 1993-03-10 | Akzo N.V. | Contraceptive implant |
| US4915954A (en) | 1987-09-03 | 1990-04-10 | Alza Corporation | Dosage form for delivering a drug at two different rates |
| US5756450A (en) | 1987-09-15 | 1998-05-26 | Novartis Corporation | Water soluble monoesters as solubilisers for pharmacologically active compounds and pharmaceutical excipients and novel cyclosporin galenic forms |
| US4886668A (en) | 1987-09-24 | 1989-12-12 | Merck & Co., Inc. | Multiparticulate controlled porosity osmotic pump |
| GB8723846D0 (en) | 1987-10-10 | 1987-11-11 | Danbiosyst Ltd | Bioadhesive microsphere drug delivery system |
| WO1989003678A1 (en) | 1987-10-30 | 1989-05-05 | Stolle Research & Development Corporation | Low residual solvent microspheres and microencapsulation process |
| US4917895A (en) | 1987-11-02 | 1990-04-17 | Alza Corporation | Transdermal drug delivery device |
| JPH0626569B2 (ja) * | 1987-11-11 | 1994-04-13 | 日機装株式会社 | 微量注出装置 |
| US4826144A (en) | 1988-04-25 | 1989-05-02 | Peter J. Balsells | Inside back angle canted coil spring |
| US4830344A (en) | 1988-04-25 | 1989-05-16 | Peter J. Balsells | Canted-coil spring with turn angle and seal |
| US5203849A (en) | 1990-03-20 | 1993-04-20 | Balsells Peter J | Canted coil spring in length filled with an elastomer |
| US4915366A (en) | 1988-04-25 | 1990-04-10 | Peter J. Balsells | Outside back angle canted coil spring |
| US5072070A (en) | 1989-12-01 | 1991-12-10 | Peter J. Balsells | Device for sealing electromagnetic waves |
| US5079388A (en) | 1989-12-01 | 1992-01-07 | Peter J. Balsells | Gasket for sealing electromagnetic waves |
| US4893795A (en) | 1988-08-15 | 1990-01-16 | Peter J. Balsells | Radially loaded canted coiled spring with turn angle |
| US5160122A (en) | 1990-03-20 | 1992-11-03 | Peter J. Balsells | Coil spring with an elastomer having a hollow coil cross section |
| US4974821A (en) | 1988-04-25 | 1990-12-04 | Peter J. Balsells | Canted-coil spring with major axis radial loading |
| US5108078A (en) | 1988-04-25 | 1992-04-28 | Peter J. Balsells | Canted-coil spring loaded while in a cavity |
| US4961253A (en) | 1988-04-25 | 1990-10-09 | Peter J. Balsells | Manufacturing method for canted-coil spring with turn angle and seal |
| DE68909295T2 (de) | 1988-04-25 | 1994-05-11 | Peter J Balsells | In sich geschlossene ringförmige Schraubenfeder mit äusserem, rückwärtigem Neigungswinkel. |
| US5117066A (en) | 1988-04-25 | 1992-05-26 | Peter J. Balsells | Retaining and locking electromagnetic gasket |
| US4964204A (en) | 1988-04-25 | 1990-10-23 | Peter J. Balsells | Method for making a garter-type axially-resilient coil spring |
| US4934666A (en) | 1988-04-25 | 1990-06-19 | Peter J. Balsells | Coiled spring electromagnetic shielding gasket |
| US4907788A (en) | 1988-04-25 | 1990-03-13 | Peter J. Balsells | Dual concentric canted-coil spring apparatus |
| US4876781A (en) | 1988-04-25 | 1989-10-31 | Peter J. Balsells | Method of making a garter-type axially resilient coiled spring |
| US4931285A (en) | 1988-04-28 | 1990-06-05 | Alza Corporation | Aqueous based pharmaceutical coating composition for dosage forms |
| US5024842A (en) | 1988-04-28 | 1991-06-18 | Alza Corporation | Annealed coats |
| US5006346A (en) | 1988-04-28 | 1991-04-09 | Alza Corporation | Delivery system |
| US5160743A (en) | 1988-04-28 | 1992-11-03 | Alza Corporation | Annealed composition for pharmaceutically acceptable drug |
| JP2827287B2 (ja) | 1988-07-05 | 1998-11-25 | 武田薬品工業株式会社 | 水溶性薬物含有徐放型マイクロカプセル |
| JP2794022B2 (ja) | 1988-11-11 | 1998-09-03 | 三生製薬株式会社 | ブナゾシン或いはその塩類含有経皮適用製剤 |
| US5110596A (en) | 1988-12-13 | 1992-05-05 | Alza Corporation | Delivery system comprising means for delivering agent to livestock |
| US5728088A (en) | 1988-12-13 | 1998-03-17 | Alza Corporation | Osmotic system for delivery of fluid-sensitive somatotropins to bovine animals |
| US5059423A (en) | 1988-12-13 | 1991-10-22 | Alza Corporation | Delivery system comprising biocompatible beneficial agent formulation |
| US5057318A (en) | 1988-12-13 | 1991-10-15 | Alza Corporation | Delivery system for beneficial agent over a broad range of rates |
| US5034229A (en) | 1988-12-13 | 1991-07-23 | Alza Corporation | Dispenser for increasing feed conversion of hog |
| US4969884A (en) | 1988-12-28 | 1990-11-13 | Alza Corporation | Osmotically driven syringe |
| US5234424A (en) | 1988-12-28 | 1993-08-10 | Alza Corporation | Osmotically driven syringe |
| US4976966A (en) | 1988-12-29 | 1990-12-11 | Alza Corporation | Delayed release osmotically driven fluid dispenser |
| IL92344A0 (en) | 1989-01-04 | 1990-07-26 | Gist Brocades Nv | Microencapsulation of bioactive substances in biocompatible polymers,microcapsules obtained and pharmaceutical preparation comprising said microcapsules |
| US5288479A (en) | 1989-01-17 | 1994-02-22 | Sterling Drug, Inc. | Extrudable elastic oral pharmaceutical gel compositions and metered dose dispensers containing them and method of making and method of use thereof |
| US5705363A (en) | 1989-03-02 | 1998-01-06 | The Women's Research Institute | Recombinant production of human interferon τ polypeptides and nucleic acids |
| US5906816A (en) | 1995-03-16 | 1999-05-25 | University Of Florida | Method for treatment of autoimmune diseases |
| US5219572A (en) | 1989-03-17 | 1993-06-15 | Pitman-Moore, Inc. | Controlled release delivery device for macromolecular proteins |
| AU620253B2 (en) | 1989-05-01 | 1992-02-13 | Alkermes Controlled Therapeutics, Inc. | Process for producing small particles of biologically active molecules |
| US5019400A (en) | 1989-05-01 | 1991-05-28 | Enzytech, Inc. | Very low temperature casting of controlled release microspheres |
| DE69024953T3 (de) | 1989-05-04 | 2005-01-27 | Southern Research Institute, Birmingham | Einkapselungsverfahren |
| US5133974A (en) | 1989-05-05 | 1992-07-28 | Kv Pharmaceutical Company | Extended release pharmaceutical formulations |
| US5126142A (en) | 1989-07-18 | 1992-06-30 | Alza Corporation | Dispenser comprising ionophore |
| US5225205A (en) | 1989-07-28 | 1993-07-06 | Debiopharm S.A. | Pharmaceutical composition in the form of microparticles |
| US5439688A (en) | 1989-07-28 | 1995-08-08 | Debio Recherche Pharmaceutique S.A. | Process for preparing a pharmaceutical composition |
| FI920856A0 (fi) | 1989-08-28 | 1992-02-26 | Pharmaceutical Delivery System | Bioeroderbar polymerer foer kontrollerad frigoerelse av terapeutiska aemnen. |
| US5112614A (en) | 1989-09-14 | 1992-05-12 | Alza Corporation | Implantable delivery dispenser |
| US5290558A (en) | 1989-09-21 | 1994-03-01 | Osteotech, Inc. | Flowable demineralized bone powder composition and its use in bone repair |
| SE465950B (sv) | 1989-10-23 | 1991-11-25 | Medinvent Sa | Kombination av ett aggregat partikelformat, kristallint eller frystorkat laekemedel med en pseudoplastisk gel foer beredning av ett injicerbart preparat samt foerfarande foer dess framstaellning |
| US5707644A (en) | 1989-11-04 | 1998-01-13 | Danbiosyst Uk Limited | Small particle compositions for intranasal drug delivery |
| US5312335A (en) | 1989-11-09 | 1994-05-17 | Bioject Inc. | Needleless hypodermic injection device |
| DK0453555T3 (da) | 1989-11-13 | 1994-01-31 | Becton Dickinson France | Flakon til opbevaring af et lægemiddelstof |
| JPH03236317A (ja) | 1989-12-06 | 1991-10-22 | Sansei Seiyaku Kk | ドパミン誘導体含有経皮用製剤 |
| US5030216A (en) | 1989-12-15 | 1991-07-09 | Alza Corporation | Osmotically driven syringe |
| US5733572A (en) | 1989-12-22 | 1998-03-31 | Imarx Pharmaceutical Corp. | Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles |
| USD326718S (en) | 1989-12-26 | 1992-06-02 | Minnesota Mining And Manufacturing Co. | Blood sensor cassette |
| US5545618A (en) | 1990-01-24 | 1996-08-13 | Buckley; Douglas I. | GLP-1 analogs useful for diabetes treatment |
| US5213809A (en) | 1990-01-24 | 1993-05-25 | Alza Corporation | Delivery system comprising means for controlling internal pressure |
| US5223266A (en) | 1990-01-24 | 1993-06-29 | Alza Corporation | Long-term delivery device with early startup |
| US5126147A (en) | 1990-02-08 | 1992-06-30 | Biosearch, Inc. | Sustained release dosage form |
| US5478564A (en) | 1990-02-22 | 1995-12-26 | Teva Pharmaceutical Industries, Ltd. | Preparation of microparticles for controlled release of water-soluble substances |
| US5122128A (en) | 1990-03-15 | 1992-06-16 | Alza Corporation | Orifice insert for a ruminal bolus |
| US5120306A (en) | 1990-03-21 | 1992-06-09 | Gosselin Leon F | Direct delivery of anti-inflammatories to the proximal small bowel |
| US5207752A (en) | 1990-03-30 | 1993-05-04 | Alza Corporation | Iontophoretic drug delivery system with two-stage delivery profile |
| US5213810A (en) | 1990-03-30 | 1993-05-25 | American Cyanamid Company | Stable compositions for parenteral administration and method of making same |
| US5324280A (en) | 1990-04-02 | 1994-06-28 | Alza Corporation | Osmotic dosage system for delivering a formulation comprising liquid carrier and drug |
| US5091188A (en) | 1990-04-26 | 1992-02-25 | Haynes Duncan H | Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs |
| US5290271A (en) | 1990-05-14 | 1994-03-01 | Jernberg Gary R | Surgical implant and method for controlled release of chemotherapeutic agents |
| US5374620A (en) | 1990-06-07 | 1994-12-20 | Genentech, Inc. | Growth-promoting composition and its use |
| US5234692A (en) | 1990-07-11 | 1993-08-10 | Alza Corporation | Delivery device with a protective sleeve |
| US5234693A (en) | 1990-07-11 | 1993-08-10 | Alza Corporation | Delivery device with a protective sleeve |
| US5180591A (en) | 1990-07-11 | 1993-01-19 | Alza Corporation | Delivery device with a protective sleeve |
| US5234695A (en) | 1990-07-24 | 1993-08-10 | Eastman Kodak Company | Water dispersible vitamin E composition |
| USD329278S (en) | 1990-10-01 | 1992-09-08 | Gallup Allen I | Infant's bathing support |
| US5300302A (en) | 1990-10-04 | 1994-04-05 | Nestec S.A. | Pharmaceutical composition in gel form in a dispensing package |
| US5529914A (en) | 1990-10-15 | 1996-06-25 | The Board Of Regents The Univeristy Of Texas System | Gels for encapsulation of biological materials |
| US5151093A (en) | 1990-10-29 | 1992-09-29 | Alza Corporation | Osmotically driven syringe with programmable agent delivery |
| US5122377A (en) | 1990-11-19 | 1992-06-16 | A.H. Robins, Company, Incorporated | Oral delivery system for veterinary drugs |
| IT1243390B (it) | 1990-11-22 | 1994-06-10 | Vectorpharma Int | Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione. |
| US5161806A (en) | 1990-12-17 | 1992-11-10 | Peter J. Balsells | Spring-loaded, hollow, elliptical ring seal |
| GB9027422D0 (en) | 1990-12-18 | 1991-02-06 | Scras | Osmotically driven infusion device |
| PT99989A (pt) | 1991-01-09 | 1994-05-31 | Alza Corp | Dispositivos biodegradaveis e composicoes para libertacao difusivel de agentes |
| NL9100160A (nl) | 1991-01-30 | 1992-08-17 | Texas Instruments Holland | Injector. |
| US5443459A (en) | 1991-01-30 | 1995-08-22 | Alza Corporation | Osmotic device for delayed delivery of agent |
| US5861166A (en) | 1991-03-12 | 1999-01-19 | Alza Corporation | Delivery device providing beneficial agent stability |
| US5113938A (en) | 1991-05-07 | 1992-05-19 | Clayton Charley H | Whipstock |
| WO1992019241A1 (en) | 1991-05-07 | 1992-11-12 | Dynagen, Inc. | A controlled, sustained release delivery system for smoking cessation |
| US5137727A (en) | 1991-06-12 | 1992-08-11 | Alza Corporation | Delivery device providing beneficial agent stability |
| EP0520119A1 (de) | 1991-06-17 | 1992-12-30 | Spirig Ag Pharmazeutische Präparate | Neue orale Diclofenaczubereitung |
| US5190765A (en) | 1991-06-27 | 1993-03-02 | Alza Corporation | Therapy delayed |
| US5252338A (en) | 1991-06-27 | 1993-10-12 | Alza Corporation | Therapy delayed |
| HU222501B1 (hu) | 1991-06-28 | 2003-07-28 | Endorecherche Inc. | MPA-t vagy MGA-t tartalmazó nyújtott hatóanyag-felszabadulású gyógyászati készítmény és eljárás előállítására |
| US5147306A (en) * | 1991-07-01 | 1992-09-15 | Gubich Stephen J | Device for puckering the flesh to facilitate injections |
| DE4122217C2 (de) | 1991-07-04 | 1997-02-13 | Merz & Co Gmbh & Co | Verfahren zur Herstellung mechanisch stabiler, gut zerfallender Komprimate aus kleinen wirkstoffhaltigen Formkörpern |
| US5288214A (en) | 1991-09-30 | 1994-02-22 | Toshio Fukuda | Micropump |
| YU87892A (sh) | 1991-10-01 | 1995-12-04 | Eli Lilly And Company Lilly Corporate Center | Injektibilne formulacije produženog otpuštanja i postupci za njihovo dobijanje i primenu |
| DE69229881T2 (de) | 1991-10-04 | 1999-12-09 | Yoshitomi Pharmaceutical Industries, Ltd. | Tablette mit verzögerter freisetzung |
| NZ244682A (en) | 1991-10-10 | 1993-12-23 | Alza Corp | Osmotically driven controlled delivery device characterised in that a |
| US5288502A (en) | 1991-10-16 | 1994-02-22 | The University Of Texas System | Preparation and uses of multi-phase microspheres |
| US5318780A (en) | 1991-10-30 | 1994-06-07 | Mediventures Inc. | Medical uses of in situ formed gels |
| US5236707A (en) | 1991-11-08 | 1993-08-17 | Dallas Biotherapeutics, Inc. | Stabilization of human interferon |
| AU3136293A (en) | 1991-11-15 | 1993-06-15 | Isp Investments Inc. | Pharmaceutical tablet with pvp having an enhanced drug dissolution rate |
| DE4137649C2 (de) | 1991-11-15 | 1997-11-20 | Gerhard Dingler | Bauelement |
| US5200195A (en) | 1991-12-06 | 1993-04-06 | Alza Corporation | Process for improving dosage form delivery kinetics |
| US5580578A (en) | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
| US5223265A (en) | 1992-01-10 | 1993-06-29 | Alza Corporation | Osmotic device with delayed activation of drug delivery |
| US5658593A (en) | 1992-01-16 | 1997-08-19 | Coletica | Injectable compositions containing collagen microcapsules |
| US5676942A (en) | 1992-02-10 | 1997-10-14 | Interferon Sciences, Inc. | Composition containing human alpha interferon species proteins and method for use thereof |
| US5308348A (en) | 1992-02-18 | 1994-05-03 | Alza Corporation | Delivery devices with pulsatile effect |
| US5456679A (en) | 1992-02-18 | 1995-10-10 | Alza Corporation | Delivery devices with pulsatile effect |
| US5209746A (en) | 1992-02-18 | 1993-05-11 | Alza Corporation | Osmotically driven delivery devices with pulsatile effect |
| JP3267972B2 (ja) | 1992-02-28 | 2002-03-25 | コラーゲン コーポレイション | 高濃度均質化コラーゲン組成物 |
| US5573934A (en) | 1992-04-20 | 1996-11-12 | Board Of Regents, The University Of Texas System | Gels for encapsulation of biological materials |
| US5656297A (en) | 1992-03-12 | 1997-08-12 | Alkermes Controlled Therapeutics, Incorporated | Modulated release from biocompatible polymers |
| US5221278A (en) | 1992-03-12 | 1993-06-22 | Alza Corporation | Osmotically driven delivery device with expandable orifice for pulsatile delivery effect |
| WO1993019739A1 (en) | 1992-03-30 | 1993-10-14 | Alza Corporation | Viscous suspensions of controlled-release drug particles |
| ZA932273B (en) | 1992-03-30 | 1993-11-26 | Alza Corp | Additives for bioerodible polymers to regulate degradation |
| US6197346B1 (en) | 1992-04-24 | 2001-03-06 | Brown Universtiy Research Foundation | Bioadhesive microspheres and their use as drug delivery and imaging systems |
| FR2690622B1 (fr) | 1992-04-29 | 1995-01-20 | Chronotec | Système de pompe à perfusion ambulatoire programmable. |
| US5314685A (en) | 1992-05-11 | 1994-05-24 | Agouron Pharmaceuticals, Inc. | Anhydrous formulations for administering lipophilic agents |
| US5711968A (en) | 1994-07-25 | 1998-01-27 | Alkermes Controlled Therapeutics, Inc. | Composition and method for the controlled release of metal cation-stabilized interferon |
| JP2651320B2 (ja) | 1992-07-16 | 1997-09-10 | 田辺製薬株式会社 | 徐放性マイクロスフェア製剤の製造方法 |
| US5413672A (en) | 1992-07-22 | 1995-05-09 | Ngk Insulators, Ltd. | Method of etching sendust and method of pattern-etching sendust and chromium films |
| US5512293A (en) | 1992-07-23 | 1996-04-30 | Alza Corporation | Oral sustained release drug delivery device |
| US5609885A (en) | 1992-09-15 | 1997-03-11 | Alza Corporation | Osmotic membrane and delivery device |
| GB9223146D0 (en) | 1992-11-05 | 1992-12-16 | Scherer Corp R P | Vented capsule |
| EP0596161B1 (en) | 1992-11-06 | 1998-02-04 | Texas Instruments Incorporated | Apparatus for subcutaneous introduction of a needle |
| DK0669128T3 (da) | 1992-11-17 | 2000-06-19 | Yoshitomi Pharmaceutical | Sustained-release mikrosfære indeholdende antipsykotikum og fremgangsmåde til at fremstille samme |
| USD342855S (en) | 1992-11-20 | 1994-01-04 | Butler Ii George D | Combined infant cushion and cover |
| US5260069A (en) | 1992-11-27 | 1993-11-09 | Anda Sr Pharmaceuticals Inc. | Pulsatile particles drug delivery system |
| SE9203594D0 (sv) | 1992-11-30 | 1992-11-30 | Christer Nystroem | Laekemedel i dispersa system |
| DK0674506T3 (da) | 1992-12-02 | 2001-01-08 | Alkermes Inc | Væksthormonholdige mikrosfærer med styret frigivelse |
| TW333456B (en) | 1992-12-07 | 1998-06-11 | Takeda Pharm Ind Co Ltd | A pharmaceutical composition of sustained-release preparation the invention relates to a pharmaceutical composition of sustained-release preparation which comprises a physiologically active peptide. |
| AU685784B2 (en) | 1993-02-23 | 1998-01-29 | Genentech Inc. | Excipient stabilization of polypeptides treated with organic solvents |
| US5368588A (en) | 1993-02-26 | 1994-11-29 | Bettinger; David S. | Parenteral fluid medication reservoir pump |
| US5981719A (en) | 1993-03-09 | 1999-11-09 | Epic Therapeutics, Inc. | Macromolecular microparticles and methods of production and use |
| WO1994021262A1 (en) | 1993-03-17 | 1994-09-29 | Alza Corporation | Device for the transdermal administration of alprazolam |
| US5514110A (en) | 1993-03-22 | 1996-05-07 | Teh; Eutiquio L. | Automatic flow control device |
| HU225496B1 (en) | 1993-04-07 | 2007-01-29 | Scios Inc | Pharmaceutical compositions of prolonged delivery, containing peptides |
| US6284727B1 (en) | 1993-04-07 | 2001-09-04 | Scios, Inc. | Prolonged delivery of peptides |
| TW360548B (en) | 1993-04-08 | 1999-06-11 | Powderject Res Ltd | Products for therapeutic use |
| NZ247516A (en) | 1993-04-28 | 1995-02-24 | Bernard Charles Sherman | Water dispersible pharmaceutical compositions comprising drug dissolved in solvent system comprising at least one alcohol and at least one surfactant |
| US5424286A (en) | 1993-05-24 | 1995-06-13 | Eng; John | Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same |
| US5639477A (en) | 1993-06-23 | 1997-06-17 | Alza Corporation | Ruminal drug delivery device |
| EP0705097B2 (en) | 1993-06-25 | 2004-01-14 | Alza Corporation | Incorporating poly-n-vinyl amide in a transdermal system |
| US5498255A (en) | 1993-08-17 | 1996-03-12 | Alza Corporation | Osmotic device for protracted pulsatile delivery of agent |
| US5385887A (en) | 1993-09-10 | 1995-01-31 | Genetics Institute, Inc. | Formulations for delivery of osteogenic proteins |
| JP2700141B2 (ja) | 1993-09-17 | 1998-01-19 | 富士化学工業株式会社 | リン酸水素カルシウム及びその製法並びにそれを用いた賦形剤 |
| WO1995009007A1 (en) | 1993-09-29 | 1995-04-06 | Alza Corporation | Monoglyceride/lactate ester permeation enhancer for oxybutynin |
| US6913767B1 (en) | 1993-10-25 | 2005-07-05 | Genentech, Inc. | Compositions for microencapsulation of antigens for use as vaccines |
| EP1649850A1 (en) | 1993-11-19 | 2006-04-26 | Alkermes Controlled Therapeutics Inc. II | Preparation of biodegradable microparticles containing a biologically active agent |
| US5650173A (en) | 1993-11-19 | 1997-07-22 | Alkermes Controlled Therapeutics Inc. Ii | Preparation of biodegradable microparticles containing a biologically active agent |
| KR100354270B1 (ko) | 1993-11-19 | 2003-02-11 | 알커메스 컨트롤드 테라포이틱스 인코퍼레이티드 Ii | 마이크로캡슐화된3-피페리디닐-치환된1,2-벤즈이속사졸및1,2-벤즈이소티아졸 |
| JPH07196479A (ja) | 1994-01-04 | 1995-08-01 | Unitika Ltd | マイクロカプセルの製造法 |
| USD358644S (en) | 1994-01-18 | 1995-05-23 | Bio Medic Data Systems, Inc. | Transponder implanter |
| US6241734B1 (en) * | 1998-08-14 | 2001-06-05 | Kyphon, Inc. | Systems and methods for placing materials into bone |
| US5540665A (en) | 1994-01-31 | 1996-07-30 | Alza Corporation | Gas driven dispensing device and gas generating engine therefor |
| AU691249B2 (en) | 1994-02-04 | 1998-05-14 | Lipocore Holding Ab | Bilayer preparations |
| US5697975A (en) | 1994-02-09 | 1997-12-16 | The University Of Iowa Research Foundation | Human cerebral cortex neural prosthetic for tinnitus |
| US5458888A (en) | 1994-03-02 | 1995-10-17 | Andrx Pharmaceuticals, Inc. | Controlled release tablet formulation |
| ATE227133T1 (de) | 1994-03-07 | 2002-11-15 | Imperial College | Verwendung von interferon-alpha 8 subtype zur herstellung von medikamenten zur behandlung von viralinfektionen der leber |
| ZA953078B (en) | 1994-04-28 | 1996-01-05 | Alza Corp | Effective therapy for epilepsies |
| EP0768867B1 (en) | 1994-06-13 | 2002-10-09 | Alza Corporation | Dosage form for administering drug in liquid formulation |
| NL9401150A (nl) | 1994-07-12 | 1996-02-01 | Nederland Ptt | Werkwijze voor het aan een ontvangzijde aanbieden van een van een zendzijde afkomstig eerste aantal videosignalen, alsmede systeem, alsmede zender, alsmede netwerk, en alsmede ontvanger. |
| ATE197396T1 (de) | 1994-07-13 | 2000-11-11 | Alza Corp | Zusammensetzung und verfahren zur förderung von transdermaler elektrotransport-darreichung |
| US5633011A (en) | 1994-08-04 | 1997-05-27 | Alza Corporation | Progesterone replacement therapy |
| US5574008A (en) | 1994-08-30 | 1996-11-12 | Eli Lilly And Company | Biologically active fragments of glucagon-like insulinotropic peptide |
| US5512549A (en) | 1994-10-18 | 1996-04-30 | Eli Lilly And Company | Glucagon-like insulinotropic peptide analogs, compositions, and methods of use |
| US5595759A (en) | 1994-11-10 | 1997-01-21 | Alza Corporation | Process for providing therapeutic composition |
| AU708529B2 (en) | 1994-11-10 | 1999-08-05 | University Of Kentucky Research Foundation, The | Implantable refillable controlled release device to deliver drugs directly to an internal portion of the body |
| FR2731150B1 (fr) | 1995-03-03 | 1997-04-18 | Oreal | Utilisation de composes amphiphiles en tant qu'agent epaississant de milieux non aqueux |
| US5844017A (en) | 1995-03-06 | 1998-12-01 | Ethicon, Inc. | Prepolymers of absorbable polyoxaesters containing amines and/or amido groups |
| US6100346A (en) | 1995-03-06 | 2000-08-08 | Ethicon, Inc. | Copolymers of polyoxaamides |
| US5618552A (en) | 1995-03-06 | 1997-04-08 | Ethicon, Inc. | Absorbable polyoxaesters |
| US5700583A (en) | 1995-03-06 | 1997-12-23 | Ethicon, Inc. | Hydrogels of absorbable polyoxaesters containing amines or amido groups |
| US5648088A (en) | 1995-03-06 | 1997-07-15 | Ethicon, Inc. | Blends of absorbable polyoxaesters containing amines and/or amide groups |
| US5698213A (en) | 1995-03-06 | 1997-12-16 | Ethicon, Inc. | Hydrogels of absorbable polyoxaesters |
| US5595751A (en) | 1995-03-06 | 1997-01-21 | Ethicon, Inc. | Absorbable polyoxaesters containing amines and/or amido groups |
| US6403655B1 (en) | 1995-03-06 | 2002-06-11 | Ethicon, Inc. | Method of preventing adhesions with absorbable polyoxaesters |
| US6147168A (en) | 1995-03-06 | 2000-11-14 | Ethicon, Inc. | Copolymers of absorbable polyoxaesters |
| US5859150A (en) | 1995-03-06 | 1999-01-12 | Ethicon, Inc. | Prepolymers of absorbable polyoxaesters |
| US5962023A (en) | 1995-03-06 | 1999-10-05 | Ethicon, Inc. | Hydrogels containing absorbable polyoxaamides |
| US5607687A (en) | 1995-03-06 | 1997-03-04 | Ethicon, Inc. | Polymer blends containing absorbable polyoxaesters |
| US5464929A (en) | 1995-03-06 | 1995-11-07 | Ethicon, Inc. | Absorbable polyoxaesters |
| US5597579A (en) | 1995-03-06 | 1997-01-28 | Ethicon, Inc. | Blends of absorbable polyoxaamides |
| IL113100A0 (en) | 1995-03-23 | 1995-06-29 | Schatz Anat | Infant's mattress |
| US5542682A (en) | 1995-03-27 | 1996-08-06 | American Variseal | Slant coil spring and seal |
| US5736159A (en) | 1995-04-28 | 1998-04-07 | Andrx Pharmaceuticals, Inc. | Controlled release formulation for water insoluble drugs in which a passageway is formed in situ |
| US5972373A (en) | 1995-05-02 | 1999-10-26 | Taisho Pharmaceutical Co., Ltd. | Taste masking pharmaceutical composition for oral administration |
| US5939286A (en) | 1995-05-10 | 1999-08-17 | University Of Florida | Hybrid interferon tau/alpha polypeptides, their recombinant production, and methods using them |
| US5922253A (en) | 1995-05-18 | 1999-07-13 | Alkermes Controlled Therapeutics, Inc. | Production scale method of forming microparticles |
| US5882676A (en) | 1995-05-26 | 1999-03-16 | Alza Corporation | Skin permeation enhancer compositions using acyl lactylates |
| US5718922A (en) | 1995-05-31 | 1998-02-17 | Schepens Eye Research Institute, Inc. | Intravitreal microsphere drug delivery and method of preparation |
| EA001413B1 (ru) | 1995-06-06 | 2001-02-26 | Ф. Хоффманн-Ля Рош Аг | Фармацевтическая композиция, содержащая ингибитор протеиназы и моноглицерид |
| PT836506E (pt) | 1995-06-07 | 2003-04-30 | Ortho Mcneil Pharm Inc | Penso transdermico para administracao de 17-desacetil norgestimato so ou em combinacao com um estrogenio |
| US5904935A (en) | 1995-06-07 | 1999-05-18 | Alza Corporation | Peptide/protein suspending formulations |
| US6129761A (en) | 1995-06-07 | 2000-10-10 | Reprogenesis, Inc. | Injectable hydrogel compositions |
| US5690952A (en) | 1995-06-07 | 1997-11-25 | Judy A. Magruder et al. | Implantable system for delivery of fluid-sensitive agents to animals |
| US6572879B1 (en) | 1995-06-07 | 2003-06-03 | Alza Corporation | Formulations for transdermal delivery of pergolide |
| US7833543B2 (en) | 1995-06-07 | 2010-11-16 | Durect Corporation | High viscosity liquid controlled delivery system and medical or surgical device |
| US5747058A (en) | 1995-06-07 | 1998-05-05 | Southern Biosystems, Inc. | High viscosity liquid controlled delivery system |
| US5782396A (en) | 1995-08-28 | 1998-07-21 | United States Surgical Corporation | Surgical stapler |
| US5906830A (en) | 1995-09-08 | 1999-05-25 | Cygnus, Inc. | Supersaturated transdermal drug delivery systems, and methods for manufacturing the same |
| US5942253A (en) | 1995-10-12 | 1999-08-24 | Immunex Corporation | Prolonged release of GM-CSF |
| GB9521125D0 (en) | 1995-10-16 | 1995-12-20 | Unilever Plc | Cosmetic composition |
| SE505146C2 (sv) | 1995-10-19 | 1997-06-30 | Biogram Ab | Partiklar för fördröjd frisättning |
| US5766620A (en) | 1995-10-23 | 1998-06-16 | Theratech, Inc. | Buccal delivery of glucagon-like insulinotropic peptides |
| GB9521805D0 (en) | 1995-10-25 | 1996-01-03 | Cortecs Ltd | Solubilisation methods |
| ES2192221T3 (es) | 1995-10-30 | 2003-10-01 | Oleoyl Estrone Developments S | Monoesteres de oleato de estrogenos para el tratamiento de la obesidad o el sobrepeso. |
| US5908621A (en) | 1995-11-02 | 1999-06-01 | Schering Corporation | Polyethylene glycol modified interferon therapy |
| ES2214551T3 (es) | 1995-11-02 | 2004-09-16 | Schering Corporation | Terapia de infusion continua de citocinas a baja dosis. |
| CA2192773C (en) | 1995-12-15 | 2008-09-23 | Hiroaki Okada | Production of sustained-release preparation for injection |
| CA2192782C (en) | 1995-12-15 | 2008-10-14 | Nobuyuki Takechi | Production of microspheres |
| AUPN723395A0 (en) | 1995-12-19 | 1996-01-18 | Macnaught Medical Pty Limited | Lubrication methods |
| US5980945A (en) | 1996-01-16 | 1999-11-09 | Societe De Conseils De Recherches Et D'applications Scientifique S.A. | Sustained release drug formulations |
| DE69625623T2 (de) | 1996-01-31 | 2003-11-06 | Sumitomo Bakelite Co. Ltd., Tokio/Tokyo | Verfahren zur Herstellung von in Epoxyharz eingekapselter Halbleitervorrichtung |
| WO1997027840A1 (en) | 1996-02-02 | 1997-08-07 | Alza Corporation | Sustained delivery of an active agent using an implantable system |
| US6132420A (en) | 1996-02-02 | 2000-10-17 | Alza Corporation | Osmotic delivery system and method for enhancing start-up and performance of osmotic delivery systems |
| US6261584B1 (en) | 1996-02-02 | 2001-07-17 | Alza Corporation | Sustained delivery of an active agent using an implantable system |
| WO1997028181A2 (en) | 1996-02-02 | 1997-08-07 | Rhomed Incorporated | Post-labeling stabilization of radiolabeled proteins and peptides |
| US6395292B2 (en) | 1996-02-02 | 2002-05-28 | Alza Corporation | Sustained delivery of an active agent using an implantable system |
| US6156331A (en) | 1996-02-02 | 2000-12-05 | Alza Corporation | Sustained delivery of an active agent using an implantable system |
| US5807876A (en) | 1996-04-23 | 1998-09-15 | Vertex Pharmaceuticals Incorporated | Inhibitors of IMPDH enzyme |
| US6245349B1 (en) | 1996-02-23 | 2001-06-12 | éLAN CORPORATION PLC | Drug delivery compositions suitable for intravenous injection |
| PT1975177E (pt) | 1996-03-01 | 2011-07-26 | Novo Nordisk As | Peptídeo supressor do apetite, sua composição e uso |
| JPH09241153A (ja) | 1996-03-04 | 1997-09-16 | Q P Corp | 静脈注射用脂肪乳剤 |
| JP2000506160A (ja) | 1996-03-08 | 2000-05-23 | ゼネカ リミテッド | 神経学的に活性な試剤としてのアゾロベンズアゼピン誘導体 |
| JP2000506865A (ja) | 1996-03-14 | 2000-06-06 | ジ イミューン リスポンス コーポレイション | インターフェロンをコードする遺伝子の標的を定めた送達 |
| US5703200A (en) | 1996-03-15 | 1997-12-30 | Ethicon, Inc. | Absorbable copolymers and blends of 6,6-dialkyl-1,4-dioxepan-2-one and its cyclic dimer |
| CA2241322C (en) | 1996-03-28 | 2009-01-13 | Takeda Chemical Industries, Ltd. | Sustained-release preparation and its production |
| US5660858A (en) | 1996-04-03 | 1997-08-26 | Research Triangle Pharmaceuticals | Cyclosporin emulsions |
| US6204022B1 (en) | 1996-04-12 | 2001-03-20 | Pepgen Corporation And University Of Florida | Low-toxicity human interferon-alpha analogs |
| US6074673A (en) | 1996-04-22 | 2000-06-13 | Guillen; Manuel | Slow-release, self-absorbing, drug delivery system |
| US5976109A (en) | 1996-04-30 | 1999-11-02 | Medtronic, Inc. | Apparatus for drug infusion implanted within a living body |
| US5792477A (en) | 1996-05-07 | 1998-08-11 | Alkermes Controlled Therapeutics, Inc. Ii | Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent |
| TW487572B (en) | 1996-05-20 | 2002-05-21 | Janssen Pharmaceutica Nv | Aqueous suspensions of 9-hydroxyrisperidone fatty acid esters |
| PT915910E (pt) | 1996-06-05 | 2006-05-31 | Roche Diagnostics Gmbh | Analogos de exendina, processos para a sua preparacao e medicamentos que os contem |
| CA2259469A1 (en) | 1996-06-05 | 1997-12-11 | Ashmont Holdings Limited | Injectable compositions |
| DE29610419U1 (de) | 1996-06-14 | 1996-10-24 | Filtertek, S.A., Plailly | Schwerkraftinfusionsvorrichtung für medizinische Infusionen |
| GB9613858D0 (en) | 1996-07-02 | 1996-09-04 | Cortecs Ltd | Hydrophobic preparations |
| US5916582A (en) | 1996-07-03 | 1999-06-29 | Alza Corporation | Aqueous formulations of peptides |
| US5932547A (en) | 1996-07-03 | 1999-08-03 | Alza Corporation | Non-aqueous polar aprotic peptide formulations |
| NZ333580A (en) | 1996-07-03 | 2000-06-23 | Alza Corp | Non-Aqueous protic peptide formulations, preferably LHRH |
| DE69730988T2 (de) | 1996-07-15 | 2006-02-23 | Alza Corp., Mountain View | Neue formulierungen zur transdermalen verabreichung von fluoxetinacetat und fluoxetinmaleat |
| AR008789A1 (es) | 1996-07-31 | 2000-02-23 | Bayer Corp | Piridinas y bifenilos substituidos |
| WO1998005351A1 (en) | 1996-08-08 | 1998-02-12 | Amylin Pharmaceuticals, Inc. | Methods for regulating gastrointestinal motility |
| WO1998007412A1 (en) | 1996-08-21 | 1998-02-26 | Alkermes Controlled Therapeutics, Inc. | Controlled release microparticles with a hydrophobic material |
| US6268343B1 (en) | 1996-08-30 | 2001-07-31 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| US6458924B2 (en) | 1996-08-30 | 2002-10-01 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| WO1998013092A1 (en) * | 1996-09-27 | 1998-04-02 | American Home Products Corporation | Tissue penetration guide |
| US5984890A (en) | 1996-09-27 | 1999-11-16 | American Home Products Corporation | Medical device for the placement of solid materials |
| US5919160A (en) | 1996-10-10 | 1999-07-06 | Sanfilippo, Ii; Dominic Joseph | Vascular access device and method of installing same |
| IN184589B (cg-RX-API-DMAC7.html) | 1996-10-16 | 2000-09-09 | Alza Corp | |
| US6004578A (en) | 1996-10-24 | 1999-12-21 | Alza Corporation | Permeation enhances for transdermal drug delivery compositions, devices and methods |
| US5817129A (en) | 1996-10-31 | 1998-10-06 | Ethicon, Inc. | Process and apparatus for coating surgical sutures |
| UA65549C2 (uk) | 1996-11-05 | 2004-04-15 | Елі Ліллі Енд Компані | Спосіб регулювання ожиріння шляхом периферійного введення аналогів та похідних glp-1 (варіанти) та фармацевтична композиція |
| DE19646392A1 (de) | 1996-11-11 | 1998-05-14 | Lohmann Therapie Syst Lts | Zubereitung zur Anwendung in der Mundhöhle mit einer an der Schleimhaut haftklebenden, Pharmazeutika oder Kosmetika zur dosierten Abgabe enthaltenden Schicht |
| US5928666A (en) | 1996-11-12 | 1999-07-27 | Cygnus Inc. | Crystalline form of estradiol and pharmaceutical formulations comprising same |
| EP1066081B1 (en) | 1996-11-15 | 2003-07-16 | ALZA Corporation | Osmotic delivery system and method for enhancing start-up and performance of osmotic delivery systems |
| GB9626513D0 (en) | 1996-12-20 | 1997-02-05 | Bioglan Ireland R & D Ltd | A pharmaceutical composition |
| DK0949905T3 (da) | 1996-12-20 | 2001-10-22 | Alza Corp | Injicertbart depotelpræparat og fremgangsmåde til fremstilling |
| CA2277112C (en) | 1997-01-07 | 2008-08-26 | Amylin Pharmaceuticals, Inc. | Use of exendins and agonists thereof for the reduction of food intake |
| JP2001511128A (ja) | 1997-01-28 | 2001-08-07 | ファルマシア・アンド・アップジョン・カンパニー | 水不溶性ポルフィリンの脂質錯体の凍結乾燥物 |
| US5945126A (en) | 1997-02-13 | 1999-08-31 | Oakwood Laboratories L.L.C. | Continuous microsphere process |
| ZA981610B (en) | 1997-03-24 | 1999-08-26 | Alza Corp | Self adjustable exit port. |
| US5874388A (en) | 1997-04-02 | 1999-02-23 | Dow Corning Corporation | Lubricant composition for disc brake caliper pin and a disc brake asembly containing the lubricant |
| US6127520A (en) | 1997-04-15 | 2000-10-03 | Regents Of The University Of Michigan | Compositions and methods for the inhibition of neurotransmitter uptake of synaptic vesicles |
| CA2286052A1 (en) | 1997-04-17 | 1998-10-29 | Lise Sylvest Nielsen | A novel bioadhesive drug delivery system based on liquid crystals |
| AR012448A1 (es) | 1997-04-18 | 2000-10-18 | Ipsen Pharma Biotech | Composicion en forma de microcapsulas o de implantes que comprende un excipiente biodegradable, polimero o co-polimero, o una mezcla de talesexcipientes, y una sustancia activa o una mezcla de sustancias activas, procedimiento para la preparacion de una sustancia soluble en agua de elevada |
| IL132323A0 (en) | 1997-04-28 | 2001-03-19 | Rhone Poulenc Rorer Sa | Adenovirus-mediated intratumoral delivery of an angiogenesis antagonist for the treatment of tumors |
| US20020039594A1 (en) | 1997-05-13 | 2002-04-04 | Evan C. Unger | Solid porous matrices and methods of making and using the same |
| US6663899B2 (en) | 1997-06-13 | 2003-12-16 | Genentech, Inc. | Controlled release microencapsulated NGF formulation |
| US6113947A (en) | 1997-06-13 | 2000-09-05 | Genentech, Inc. | Controlled release microencapsulated NGF formulation |
| SI9700186B (sl) | 1997-07-14 | 2006-10-31 | Lek, Tovarna Farmacevtskih In Kemicnih Izdelkov, D.D. | Nova farmacevtska oblika z nadzorovanim sproscanjem zdravilnih ucinkovin |
| MY125849A (en) | 1997-07-25 | 2006-08-30 | Alza Corp | Osmotic delivery system, osmotic delivery system semipermeable body assembly, and method for controlling delivery rate of beneficial agents from osmotic delivery systems |
| MY125870A (en) | 1997-07-25 | 2006-08-30 | Alza Corp | Osmotic delivery system flow modulator apparatus and method |
| US7157555B1 (en) | 1997-08-08 | 2007-01-02 | Amylin Pharmaceuticals, Inc. | Exendin agonist compounds |
| GB9718986D0 (en) | 1997-09-09 | 1997-11-12 | Danbiosyst Uk | Controlled release microsphere delivery system |
| US6023802A (en) | 1997-09-10 | 2000-02-15 | King; Susan Melton | Infant sleeper |
| US6172046B1 (en) | 1997-09-21 | 2001-01-09 | Schering Corporation | Combination therapy for eradicating detectable HCV-RNA in patients having chronic Hepatitis C infection |
| US5989463A (en) | 1997-09-24 | 1999-11-23 | Alkermes Controlled Therapeutics, Inc. | Methods for fabricating polymer-based controlled release devices |
| JPH11100353A (ja) | 1997-09-29 | 1999-04-13 | Esupo Kk | 精製・脱臭液状エステルワックスとその組成物 |
| JP2001517692A (ja) | 1997-09-29 | 2001-10-09 | インヘール セラピューティック システムズ， インコーポレイテッド | ネブライザにおける使用のための安定化調製物 |
| US6133429A (en) | 1997-10-03 | 2000-10-17 | Becton Dickinson And Company | Chromophores useful for the preparation of novel tandem conjugates |
| USD399821S (en) | 1997-11-07 | 1998-10-20 | Motorola, Inc. | Front section of a battery charger |
| JP2001523688A (ja) | 1997-11-14 | 2001-11-27 | アミリン・ファーマシューティカルズ，インコーポレイテッド | 新規エキセンジン・アゴニスト化合物 |
| AU761577C (en) | 1997-12-08 | 2004-02-05 | Genentech Inc. | Human interferon-epsilon: a type I interferon |
| US6368612B1 (en) | 1997-12-12 | 2002-04-09 | Biohybrid Technologies Llc | Devices for cloaking transplanted cells |
| ES2182379T3 (es) | 1997-12-22 | 2003-03-01 | Alza Corp | Membrana de regulacion del regimen de liberacion para dispositivos de administracion controlada de farmacos. |
| DK1300174T3 (da) | 1997-12-29 | 2005-06-20 | Alza Corp | Kit til at indsætte et implantat |
| ATE289212T1 (de) | 1997-12-29 | 2005-03-15 | Alza Corp | Phiole für implantat |
| DE69822208T2 (de) | 1997-12-29 | 2005-04-28 | Alza Corp., Mountain View | Osmotisches verabreichungssystem mit stöpselrückhaltemechanismus |
| ATE342051T1 (de) | 1997-12-30 | 2006-11-15 | Alza Corp | Verabreichungssystem für wirkstoffe mit einem membranstöpsel |
| US20040024068A1 (en) | 1998-01-23 | 2004-02-05 | Trustees Of Tufts College | Antimicrobial compounds |
| IT1298575B1 (it) | 1998-02-06 | 2000-01-12 | Vectorpharma Int | Composizioni farmaceutiche in forma di nanoparticelle comprendenti sostanze lipidiche e sostanze antifiliche e relativo processo di |
| US6017545A (en) | 1998-02-10 | 2000-01-25 | Modi; Pankaj | Mixed micellar delivery system and method of preparation |
| CA2320371C (en) | 1998-02-13 | 2012-01-17 | Amylin Pharmaceuticals, Inc. | Inotropic and diuretic effects of exendin and glp-1 |
| US6703359B1 (en) | 1998-02-13 | 2004-03-09 | Amylin Pharmaceuticals, Inc. | Inotropic and diuretic effects of exendin and GLP-1 |
| USD408917S (en) | 1998-02-26 | 1999-04-27 | Minnesota Mining And Manufacturing Company | Membrane support structure of a flow through cell for blood gas measurement |
| US6224577B1 (en) | 1998-03-02 | 2001-05-01 | Medrad, Inc. | Syringes and plungers for use therein |
| US6056718A (en) * | 1998-03-04 | 2000-05-02 | Minimed Inc. | Medication infusion set |
| US6245357B1 (en) | 1998-03-06 | 2001-06-12 | Alza Corporation | Extended release dosage form |
| US6183461B1 (en) | 1998-03-11 | 2001-02-06 | Situs Corporation | Method for delivering a medication |
| WO1999046332A1 (en) | 1998-03-12 | 1999-09-16 | Daicel Chemical Industries, Ltd. | Lactone-containing resin composition, molded object thereof, and film |
| US6029361A (en) | 1998-03-25 | 2000-02-29 | Ultratech Stepper, Inc. | Air-guage nozzle probe structure for microlithographic image focusing |
| US6074660A (en) | 1998-04-20 | 2000-06-13 | Ethicon, Inc. | Absorbable polyoxaesters containing amines and/ or amido groups |
| TW586944B (en) | 1998-05-29 | 2004-05-11 | Sumitomo Pharma | Controlled release agent having a multi-layer structure |
| US8626302B2 (en) | 1998-06-03 | 2014-01-07 | Spr Therapeutics, Llc | Systems and methods to place one or more leads in muscle for providing electrical stimulation to treat pain |
| NZ527473A (en) | 1998-06-12 | 2005-02-25 | Amylin Pharmaceuticals Inc | Glucagon-like peptide-1 improves beta-cell response to glucose in subjects with impaired glucose tolerance |
| US6245052B1 (en) | 1998-07-08 | 2001-06-12 | Innerdyne, Inc. | Methods, systems, and kits for implanting articles |
| WO2000003660A1 (en) | 1998-07-17 | 2000-01-27 | Skyepharma, Inc. | Biodegradable compositions for the controlled release of encapsulated substances |
| US6472512B1 (en) | 1998-07-21 | 2002-10-29 | Human Genome Sciences, Inc. | Keratinocyte derived interferon |
| US7390637B2 (en) | 1998-07-21 | 2008-06-24 | Human Genome Sciences, Inc. | Keratinocyte derived interferon |
| US6270700B1 (en) | 1998-07-23 | 2001-08-07 | Societe De Conseils De Recherches Et D'applications Scientifiques, Sas | Encapsulation of water soluble peptides |
| USD415073S (en) | 1998-08-17 | 1999-10-12 | ScooterBug, Inc. | Stroller |
| US6720407B1 (en) | 1998-08-28 | 2004-04-13 | Eli Lilly And Company | Method for administering insulinotropic peptides |
| US6551613B1 (en) | 1998-09-08 | 2003-04-22 | Alza Corporation | Dosage form comprising therapeutic formulation |
| US6174547B1 (en) | 1999-07-14 | 2001-01-16 | Alza Corporation | Dosage form comprising liquid formulation |
| HU226669B1 (en) | 1998-09-09 | 2009-06-29 | Alza Corp | Dosage form comprising liquid formulation |
| US5951521A (en) | 1998-09-25 | 1999-09-14 | Minimed Inc. | Subcutaneous implantable sensor set having the capability to remove deliver fluids to an insertion site |
| US6248112B1 (en) | 1998-09-30 | 2001-06-19 | C. R. Bard, Inc. | Implant delivery system |
| US6645192B2 (en) | 1998-09-30 | 2003-11-11 | Ivy Animal Health, Inc. | Pellet implant system for immediate and delayed release of antiparasitic drug |
| US6284725B1 (en) | 1998-10-08 | 2001-09-04 | Bionebraska, Inc. | Metabolic intervention with GLP-1 to improve the function of ischemic and reperfused tissue |
| CN1325301A (zh) | 1998-11-02 | 2001-12-05 | 阿尔扎有限公司 | 活性物质的控制释放 |
| WO2000029206A1 (en) | 1998-11-13 | 2000-05-25 | Sensor Technologies Inc. | Monodisperse preparations useful with implanted devices |
| RU2154501C1 (ru) | 1998-11-20 | 2000-08-20 | Григорьянц Рубен Исаакович | Шприц для имплантации тканей в подкожную клетчатку |
| US20030060425A1 (en) | 1998-11-24 | 2003-03-27 | Ahlem Clarence N. | Immune modulation method using steroid compounds |
| CN100540566C (zh) | 1998-12-07 | 2009-09-16 | 研究及应用科学协会股份有限公司 | 胰高血糖素样肽-1的类似物 |
| NZ512410A (en) | 1998-12-17 | 2003-02-28 | Alza Corp | Controlled release liquid filled gelatin capsules comprising barrier, expandable and superpermeable layers and an orifice |
| AU769610B2 (en) | 1998-12-23 | 2004-01-29 | Amgen, Inc. | Polyol/oil suspensions for the sustained release of proteins |
| US6433144B1 (en) | 1999-01-12 | 2002-08-13 | Viragen, Inc. | Compositions of highly-purified natural mixtures of type I Interferon derived from leukocytes and methods |
| EP1140144A4 (en) | 1998-12-31 | 2002-10-30 | Viragen Inc | METHODS AND COMPOSITION OF EXTREMELY PURIFIED NATURAL MIXTURES OF TYPE I INTERFERONS DERIVED FROM LEUCOCYTES |
| PT1140014E (pt) | 1998-12-31 | 2003-07-31 | Alza Corp | Sistema de distribuicao osmotico que possui embolo com utilizacao eficaz de espaco |
| WO2000040273A2 (en) | 1999-01-08 | 2000-07-13 | Vical Incorporated | Treatment of viral diseases using an interferon omega expressing polynucleotide |
| US6703225B1 (en) | 1999-01-12 | 2004-03-09 | Sumitomo Pharmaceuticals Company, Limited | Interferon-α |
| EP1143989B1 (en) | 1999-01-14 | 2006-12-13 | Amylin Pharmaceuticals, Inc. | Exendins for glucagon suppression |
| EP1609478A1 (en) | 1999-01-14 | 2005-12-28 | Amylin Pharmaceuticals, Inc. | Exendin agonist peptide formulations |
| US7399489B2 (en) | 1999-01-14 | 2008-07-15 | Amylin Pharmaceuticals, Inc. | Exendin analog formulations |
| EP1666026B2 (en) | 1999-02-08 | 2015-02-25 | Intarcia Therapeutics, Inc | Non-aqueous single phase biocompatible viscous vehicles and methods for preparing the same |
| US7919109B2 (en) | 1999-02-08 | 2011-04-05 | Intarcia Therapeutics, Inc. | Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles |
| US7258869B1 (en) | 1999-02-08 | 2007-08-21 | Alza Corporation | Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicle |
| US6451974B1 (en) | 1999-03-17 | 2002-09-17 | Novo Nordisk A/S | Method of acylating peptides and novel acylating agents |
| US6541021B1 (en) | 1999-03-18 | 2003-04-01 | Durect Corporation | Devices and methods for pain management |
| US6835194B2 (en) | 1999-03-18 | 2004-12-28 | Durect Corporation | Implantable devices and methods for treatment of pain by delivery of fentanyl and fentanyl congeners |
| US6440463B1 (en) | 1999-04-05 | 2002-08-27 | Pharmaceutical Discovery Corporation | Methods for fine powder formation |
| GB9907658D0 (en) | 1999-04-06 | 1999-05-26 | Zeneca Ltd | Chemical compounds |
| WO2000062799A1 (en) | 1999-04-19 | 2000-10-26 | Schering Corporation | Hcv combination therapy, containing ribavirin in association with antioxidants |
| US6924264B1 (en) | 1999-04-30 | 2005-08-02 | Amylin Pharmaceuticals, Inc. | Modified exendins and exendin agonists |
| US6291013B1 (en) | 1999-05-03 | 2001-09-18 | Southern Biosystems, Inc. | Emulsion-based processes for making microparticles |
| AU4917900A (en) | 1999-05-07 | 2000-11-21 | Pharmasol Gmbh | Lipid particles on the basis of mixtures of liquid and solid lipids and method for producing same |
| USD430671S (en) | 1999-05-10 | 2000-09-05 | Shute Wallace B | Obstetrical forceps |
| CA2363712C (en) | 1999-05-17 | 2011-05-10 | Conjuchem Inc. | Long lasting insulinotropic peptides |
| US6887470B1 (en) | 1999-09-10 | 2005-05-03 | Conjuchem, Inc. | Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components |
| US6849714B1 (en) | 1999-05-17 | 2005-02-01 | Conjuchem, Inc. | Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components |
| US6514500B1 (en) | 1999-10-15 | 2003-02-04 | Conjuchem, Inc. | Long lasting synthetic glucagon like peptide {GLP-!} |
| US6506724B1 (en) | 1999-06-01 | 2003-01-14 | Amylin Pharmaceuticals, Inc. | Use of exendins and agonists thereof for the treatment of gestational diabetes mellitus |
| WO2000074736A1 (en) | 1999-06-04 | 2000-12-14 | Delrx Pharmaceutical Corporation | Formulations comprising dehydrated particles of pharmaceutical agents and process for preparing the same |
| KR100844295B1 (ko) | 1999-06-04 | 2008-07-07 | 알자 코포레이션 | 이식성 겔 조성물 및 이의 제조방법 |
| US20030059376A1 (en) | 1999-06-04 | 2003-03-27 | Libbey Miles A. | Formulations comprising dehydrated particles of pharmaceutical agents and process for preparing the same |
| US20010040326A1 (en) | 1999-06-14 | 2001-11-15 | Lord Corporation | Resilient member with deformed element and method of forming same |
| US6833256B1 (en) | 1999-06-22 | 2004-12-21 | University Of Maryland | Interferon tau mutants and methods for making them |
| US6528486B1 (en) | 1999-07-12 | 2003-03-04 | Zealand Pharma A/S | Peptide agonists of GLP-1 activity |
| USD445975S1 (en) | 1999-08-27 | 2001-07-31 | Black & Decker, Inc. | Base unit for a hand held vacuum cleaner |
| SE9903236D0 (sv) | 1999-09-10 | 1999-09-10 | Astra Ab | Method to obtain microparticles |
| AU8026600A (en) * | 1999-10-15 | 2001-04-30 | Deschutes Medical Products, Inc. | Brachytherapy instrument and methods |
| US6458387B1 (en) | 1999-10-18 | 2002-10-01 | Epic Therapeutics, Inc. | Sustained release microspheres |
| US6284283B1 (en) | 1999-10-21 | 2001-09-04 | Alkermes Controlled Therapeutics, Inc. | Method of producing sub-micron particles of biologically active agents and uses thereof |
| US6741688B1 (en) * | 1999-10-28 | 2004-05-25 | Cisco Technology, Inc. | Method and apparatus for handling telephone calls |
| US6436091B1 (en) | 1999-11-16 | 2002-08-20 | Microsolutions, Inc. | Methods and implantable devices and systems for long term delivery of a pharmaceutical agent |
| US7022674B2 (en) | 1999-12-16 | 2006-04-04 | Eli Lilly And Company | Polypeptide compositions with improved stability |
| WO2001043528A2 (en) | 1999-12-17 | 2001-06-21 | Durect Corporation | Devices and methods in intracerebrospinal delivery of morphine-6-glucuronide |
| ATE306908T1 (de) | 1999-12-21 | 2005-11-15 | Alza Corp | Ventil für osmotische vorrichtungen |
| US6283949B1 (en) | 1999-12-27 | 2001-09-04 | Advanced Cardiovascular Systems, Inc. | Refillable implantable drug delivery pump |
| US6572890B2 (en) | 2000-01-13 | 2003-06-03 | Osmotica Corp. | Osmotic device containing venlafaxine and an anti-psychotic agent |
| US6472060B1 (en) | 2000-01-19 | 2002-10-29 | Seco Tools Ab | Coated body with nanocrystalline CVD coating for enhanced edge toughness and reduced friction |
| US6844321B2 (en) | 2000-01-31 | 2005-01-18 | Novo Nordisk A/S | Crystallization of a GLP-1 analogue |
| US6465425B1 (en) | 2000-02-10 | 2002-10-15 | Alkermes Controlled Therapeutics, Inc. | Microencapsulation and sustained release of biologically active acid-stable or free sulfhydryl-containing proteins |
| US6471688B1 (en) * | 2000-02-15 | 2002-10-29 | Microsolutions, Inc. | Osmotic pump drug delivery systems and methods |
| US6464688B1 (en) | 2000-02-15 | 2002-10-15 | Microsolutions, Inc. | Osmotic pump delivery system with flexible drug compartment |
| US20030220644A1 (en) * | 2002-05-23 | 2003-11-27 | Thelen Sarah L. | Method and apparatus for reducing femoral fractures |
| MXPA02009031A (es) | 2000-03-14 | 2004-08-19 | Amylin Pharmaceuticals Inc | Efectos del peptido-1(7-36) tipo glucagon en la motilidad antro-piloro.duodenal. |
| US20030211974A1 (en) | 2000-03-21 | 2003-11-13 | Brodbeck Kevin J. | Gel composition and methods |
| TWI250874B (en) | 2000-03-24 | 2006-03-11 | Nat Health Research Institutes | Pharmaceutical compositions for preventing or treating disorders associated with bacterial or viral infection |
| DE60115005T2 (de) | 2000-04-19 | 2006-07-27 | Genentech Inc., San Francisco | Formulierungen mit verzögerter freisetzung enthaltend wachstumshormon |
| CA2407074A1 (en) | 2000-04-21 | 2001-11-01 | Jukka Hartikka | Compositions and methods for in vivo delivery of polynucleotide-based therapeutics |
| JP2001357075A (ja) | 2000-04-27 | 2001-12-26 | El-Con System Co Ltd | 二次元ｃａｄインターフェースを利用した物量割出しシステムとその方法 |
| EP1282436B1 (en) | 2000-05-19 | 2008-06-11 | Amylin Pharmaceuticals, Inc. | Treatment of acute coronary syndrome with glp-1 |
| US6495164B1 (en) | 2000-05-25 | 2002-12-17 | Alkermes Controlled Therapeutics, Inc. I | Preparation of injectable suspensions having improved injectability |
| ES2275685T3 (es) | 2000-06-16 | 2007-06-16 | Eli Lilly And Company | Analogos del peptido similar a glucagon 1. |
| US6479065B2 (en) | 2000-08-10 | 2002-11-12 | Alkermes Controlled Therapeutics, Inc. | Process for the preparation of polymer-based sustained release compositions |
| US6547250B1 (en) | 2000-08-21 | 2003-04-15 | Westport Research Inc. | Seal assembly with two sealing mechanisms for providing static and dynamic sealing |
| US8454552B2 (en) | 2000-08-24 | 2013-06-04 | Cardiac Science Corporation | Method for constructing an instrument with a covered bore for subcutaneous implantation |
| US8251946B2 (en) * | 2000-08-24 | 2012-08-28 | Cardiac Science, Inc. | Method for constructing an instrument with a two-part plunger for subcutaneous implantation |
| US6824822B2 (en) | 2001-08-31 | 2004-11-30 | Alkermes Controlled Therapeutics Inc. Ii | Residual solvent extraction method and microparticles produced thereby |
| WO2002028366A2 (en) | 2000-10-06 | 2002-04-11 | Durect Corporation | Devices and methods for management of inflammation |
| WO2002036072A2 (en) | 2000-11-03 | 2002-05-10 | Biomedicines, Inc. | Method for short-term and long-term drug dosimetry |
| WO2002067895A2 (en) | 2000-11-16 | 2002-09-06 | Durect Corporation | Implant dosage form and use thereof for the delivery of a cholesterol lowering agent |
| US20050070883A1 (en) | 2000-11-29 | 2005-03-31 | Brown James E | Devices and methods for controlled delivery from a drug delivery device |
| US20020165286A1 (en) | 2000-12-08 | 2002-11-07 | Hanne Hedeman | Dermal anti-inflammatory composition |
| AU2002228608A1 (en) | 2000-12-13 | 2002-06-24 | Eli Lilly And Company | Amidated glucagon-like peptide-1 |
| MXPA03005135A (es) | 2000-12-13 | 2003-12-04 | Lilly Co Eli | Regimen de tratamiento cronico usando peptidos insulinotropicos similares al glucagon. |
| US8273713B2 (en) | 2000-12-14 | 2012-09-25 | Amylin Pharmaceuticals, Llc | Methods of treating obesity using PYY[3-36] |
| ATE361057T1 (de) | 2000-12-21 | 2007-05-15 | Alrise Biosystems Gmbh | Verfahren umfassend einen induzierten phasenübergang zur herstellung von hydrophobe wirkstoffe enthaltenden mikropartikeln |
| USD472896S1 (en) | 2000-12-23 | 2003-04-08 | Andreas Peiker | Telephone support |
| IN188924B (cg-RX-API-DMAC7.html) | 2001-03-01 | 2002-11-23 | Bharat Serums & Vaccines Ltd | |
| CA2440387A1 (en) | 2001-03-23 | 2002-10-03 | Durect Corporation | Delivery of drugs from sustained release devices implanted in myocardial tissue or in the pericardial space |
| BR0116973A (pt) | 2001-04-13 | 2004-10-13 | Becton Dickinson Co | Método de injetar substâncias de forma intradérmica |
| US6632217B2 (en) | 2001-04-19 | 2003-10-14 | Microsolutions, Inc. | Implantable osmotic pump |
| AU2002308706A1 (en) | 2001-06-01 | 2002-12-16 | Eli Lilly And Company | Glp-1 formulations with protracted time action |
| US6514517B2 (en) | 2001-06-20 | 2003-02-04 | Ethicon, Inc. | Antimicrobial coatings for medical devices |
| DK1397155T3 (en) | 2001-06-21 | 2015-12-07 | Genentech Inc | Prolonged release formulation |
| ATE478656T1 (de) | 2001-06-22 | 2010-09-15 | Univ Johns Hopkins Med | Biologisch abbaubare polymerzusammensetzungen, zusammensetzungen und damit in beziehung stehende verwendungen |
| US7163688B2 (en) | 2001-06-22 | 2007-01-16 | Alza Corporation | Osmotic implant with membrane and membrane retention means |
| MXPA03011922A (es) | 2001-06-22 | 2004-03-26 | Pfizer Prod Inc | Composiciones farmaceuticas que contienen un dispersion solida de un farmaco ligeramente soluble en una matriz y plimero mejorador de solubilidad. |
| US20030138403A1 (en) | 2001-06-29 | 2003-07-24 | Maxygen Aps | Interferon formulations |
| HUP0401156A2 (hu) | 2001-07-20 | 2004-12-28 | Intermune, Inc. | Májfibrózis kezelésére szolgáló módszerek |
| EP2022505B1 (en) | 2001-07-31 | 2011-12-14 | The Government of the United States of America, as represented by the Secretary of the Department of Health and Human Services | GLP-1, exendin-4, peptide analogs and uses thereof |
| AU2002322403A1 (en) | 2001-08-23 | 2003-03-10 | Eli Lilly And Company | Glucagon-like peptide-1 analogs |
| GB0121709D0 (en) | 2001-09-07 | 2001-10-31 | Imp College Innovations Ltd | Food inhibition agent |
| EP1424957A2 (en) | 2001-09-14 | 2004-06-09 | Francis J. Martin | Microfabricated nanopore device for sustained release of therapeutic agent |
| DE60233811D1 (de) | 2001-09-17 | 2009-11-05 | Durect Corp | Vorrichtung und verfahren zur genauen abgabe eines wirkstoffs |
| ATE419863T1 (de) | 2001-09-24 | 2009-01-15 | Imp Innovations Ltd | Pyy3-36 zur zur reduzierung oder vorbeugung von fettleibigkeit |
| US7041646B2 (en) | 2001-10-05 | 2006-05-09 | Bayer Pharmaceuticals Corporation | Methods of treating type 2 diabetes with peptides acting as both GLP-1 receptor agonists and glucagon receptor antagonists |
| CN1738635A (zh) | 2001-10-05 | 2006-02-22 | 印特缪恩股份有限公司 | 用多阶段干扰素传递曲线治疗肝炎病毒感染的方法 |
| US20030078618A1 (en) | 2001-10-19 | 2003-04-24 | Fey Kate E. | System and method for removing implanted devices |
| JP4398728B2 (ja) | 2001-10-24 | 2010-01-13 | メド−エル・エレクトロメディツィニシェ・ゲラーテ・ゲーエムベーハー | 埋込み式流体配送装置と埋込み式電極 |
| US20040142902A1 (en) | 2001-11-08 | 2004-07-22 | Struijker- Boudier Harry A.J. | Implant dosage form and use thereof for the delivery of a cholosterol lowering agent |
| US20030143197A1 (en) | 2001-11-09 | 2003-07-31 | Moran S. Mark | Method for treating diseases with omega interferon |
| JP5078217B2 (ja) | 2001-11-14 | 2012-11-21 | デュレクト コーポレーション | 注入可能なデポー組成物およびそれらの使用 |
| KR20040058101A (ko) | 2001-11-14 | 2004-07-03 | 알자 코포레이션 | 카테터 주입가능한 데포 조성물 및 그의 용도 |
| BR0206469A (pt) | 2001-11-14 | 2004-01-13 | Alza Corp | Composição injetável para depósito |
| DE10159217A1 (de) | 2001-11-27 | 2003-06-05 | Schering Ag | 17alpha-Alkyl-17ß-oxy-estratriene und Zwischenprodukte zu deren Herstellung, Verwendung der 17alpha-Alkyl-17ß-oxy-estratriene zur Herstellung von Arzneimitteln sowie pharmazeutische Präparate |
| US20030108608A1 (en) | 2001-12-12 | 2003-06-12 | Erik Laridon | Thermoplastic articles comprising silver-containing antimicrobials and high amounts of carboxylic acid salts for increased surface-available silver |
| AU2002357930B2 (en) | 2001-12-19 | 2007-06-28 | Alza Corporation | Formulation & dosage form for the controlled delivery of therapeutic agents |
| EP2261250B1 (en) | 2001-12-21 | 2015-07-01 | Human Genome Sciences, Inc. | GCSF-Albumin fusion proteins |
| US8058233B2 (en) | 2002-01-10 | 2011-11-15 | Oregon Health And Science University | Modification of feeding behavior using PYY and GLP-1 |
| US7105489B2 (en) | 2002-01-22 | 2006-09-12 | Amylin Pharmaceuticals, Inc. | Methods and compositions for treating polycystic ovary syndrome |
| JP2005517012A (ja) | 2002-02-08 | 2005-06-09 | アルカーメス コントロールド セラピューティクス，インコーポレイテッド | 持続放出のためのポリマーベース組成物 |
| EP1478406B1 (en) | 2002-02-27 | 2011-01-05 | PharmaIN Corporation | Compositions for delivery of therapeutics and other materials, and methods of making and using the same |
| US7635463B2 (en) | 2002-02-27 | 2009-12-22 | Pharmain Corporation | Compositions for delivery of therapeutics and other materials |
| GB0204722D0 (en) | 2002-02-28 | 2002-04-17 | Norferm Da | Method |
| GB2386066A (en) | 2002-02-28 | 2003-09-10 | Norbrook Lab Ltd | Long-acting parasiticidal composition with improved bioavailability comprising a salicylanilide, a further anti-parasitic compound & a polymeric species |
| JP2006512102A (ja) | 2002-04-11 | 2006-04-13 | メディミューン・ヴァクシンズ・インコーポレーテッド | 噴霧乾燥による生物活性材料の防腐 |
| AU2003240493B2 (en) | 2002-05-31 | 2008-06-12 | L. Molteni & C. Dei Fratelli Alitti Societa' Di Esercizio S.P.A. | Implantable polymeric device for sustained release of buprenorphine |
| JP2005533782A (ja) | 2002-06-17 | 2005-11-10 | アルザ コーポレイション | 流体ビヒクル中に分散した浸透剤を含む、押出し力が早く零次になる機関を有する浸透送出システム |
| US20040001889A1 (en) | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
| CN100453130C (zh) | 2002-06-26 | 2009-01-21 | 精达制药公司 | 用于渗透性药物传递系统的最低顺应性和高容积效率的活塞 |
| US7177526B2 (en) | 2002-06-28 | 2007-02-13 | Intel Corporation | System and method for improving audio during post-production of video recordings |
| EP1539101B1 (en) | 2002-07-31 | 2009-01-07 | ALZA Corporation | Injectable multimodal polymer depot compositions and uses thereof |
| EP1526835B1 (en) | 2002-07-31 | 2008-04-23 | ALZA Corporation | Injectable depot compositions and uses thereof |
| US20080260838A1 (en) | 2003-08-01 | 2008-10-23 | Mannkind Corporation | Glucagon-like peptide 1 (glp-1) pharmaceutical formulations |
| WO2004022140A1 (en) | 2002-09-04 | 2004-03-18 | Ruark Botha | Device for securing a blood vessel cannula to a body |
| CN1301692C (zh) * | 2002-09-18 | 2007-02-28 | 阿勒根公司 | 眼植入物导入的器械 |
| WO2004035762A2 (en) | 2002-10-17 | 2004-04-29 | Alkermes Controlled Therapeutics, Inc. Ii | Microencapsulation and sustained release of biologically active polypeptides |
| EP1567127A4 (en) | 2002-10-17 | 2007-02-21 | Alkermes Inc | METHOD FOR MODIFYING THE RELEASE PROFILE OF COMPRESSED RELATED COMPOSITION COMPOSITIONS |
| BR0315523A (pt) | 2002-10-22 | 2005-08-30 | Waratah Pharmaceuticals Inc | Tratamento de diabetes |
| KR20050088288A (ko) | 2002-11-06 | 2005-09-05 | 알자 코포레이션 | 제어식 방출 데포 제형 |
| US6969702B2 (en) | 2002-11-20 | 2005-11-29 | Neuronova Ab | Compounds and methods for increasing neurogenesis |
| US7014636B2 (en) | 2002-11-21 | 2006-03-21 | Alza Corporation | Osmotic delivery device having a two-way valve and a dynamically self-adjusting flow channel |
| US7790681B2 (en) | 2002-12-17 | 2010-09-07 | Amylin Pharmaceuticals, Inc. | Treatment of cardiac arrhythmias with GLP-1 receptor ligands |
| US7731947B2 (en) | 2003-11-17 | 2010-06-08 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising an interferon particle formulation and suspending vehicle |
| EP1578398A2 (en) | 2002-12-19 | 2005-09-28 | ALZA Corporation | Stable, non-aqueous, single-phase gels and formulations thereof for delivery from an implantable device |
| GB0300571D0 (en) | 2003-01-10 | 2003-02-12 | Imp College Innovations Ltd | Modification of feeding behaviour |
| JP2004238392A (ja) | 2003-01-14 | 2004-08-26 | Nipro Corp | 安定化された蛋白質性製剤 |
| US7507114B2 (en) | 2003-02-18 | 2009-03-24 | Medconx, Inc. | Male medical device electrical connector with engineered friction fit |
| KR20060017749A (ko) | 2003-03-31 | 2006-02-27 | 알자 코포레이션 | 내압 소멸 수단을 갖는 삼투성 펌프 |
| BRPI0408921A (pt) | 2003-03-31 | 2006-03-28 | Alza Corp | sistema de distribuição osmótico e método para diminuir os tempos de inìcio para os sistemas de distribuição osmóticos |
| RU2005133427A (ru) | 2003-03-31 | 2006-04-27 | Алза Корпорейшн (Us) | Безводные однофазные носители и препараты с использованием таких носителей |
| US7214206B2 (en) * | 2003-04-03 | 2007-05-08 | Valera Pharmaceuticals, Inc. | Implanting device and method of using same |
| CA2748661C (en) * | 2003-05-01 | 2016-10-11 | Medgenics Inc. | Dermal micro organs, methods and apparatuses for producing and using the same |
| BRPI0410377A (pt) | 2003-05-16 | 2006-06-13 | Blue Membranes Gmbh | implantes medicinais revestidos bio-compatìveis |
| US20040247672A1 (en) | 2003-05-16 | 2004-12-09 | Alkermes Controlled Therapeutics, Inc. | Injectable sustained release compositions |
| WO2004108111A1 (en) | 2003-05-30 | 2004-12-16 | Alza Corporation | Implantable elastomeric depot compositions, uses thereof and method of manufacturing |
| US8008255B2 (en) | 2003-05-30 | 2011-08-30 | Amylin Pharmaceuticals, Inc. | Methods and compositions for enhanced transmucosal delivery of peptides and proteins |
| JP4936884B2 (ja) | 2003-06-03 | 2012-05-23 | ノボ・ノルデイスク・エー／エス | 安定化された薬学的ペプチド組成物 |
| US8491571B2 (en) | 2003-06-12 | 2013-07-23 | Cordis Corporation | Orifice device having multiple channels with varying flow rates for drug delivery |
| US7454765B2 (en) | 2003-07-09 | 2008-11-18 | Samsung Electronics Co., Ltd. | Optical disc drive |
| US20120289859A9 (en) * | 2003-08-27 | 2012-11-15 | Nicoson Zachary R | System and method for minimally invasive disease therapy |
| US7205409B2 (en) | 2003-09-04 | 2007-04-17 | Abbott Laboratories | Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV) |
| US9005244B2 (en) | 2003-09-30 | 2015-04-14 | Ethicon, Inc. | Tissue approximation device |
| MXPA06002967A (es) | 2003-09-30 | 2006-06-14 | Alza Corp | Aparato de suministro de agente activo de conduccion osmotica que proporciona perfil de liberacion ascendente. |
| MXPA06002030A (es) | 2003-10-31 | 2006-05-17 | Alza Corp | Bomba osmotica con tapon de membrana de auto-retencion, de rapido inicio. |
| CA2545027A1 (en) | 2003-11-06 | 2005-05-26 | Alza Corporation | Modular imbibition rate reducer for use with implantable osmotic pump |
| US20050106214A1 (en) | 2003-11-14 | 2005-05-19 | Guohua Chen | Excipients in drug delivery vehicles |
| US20050281879A1 (en) | 2003-11-14 | 2005-12-22 | Guohua Chen | Excipients in drug delivery vehicles |
| US20050118206A1 (en) | 2003-11-14 | 2005-06-02 | Luk Andrew S. | Surfactant-based gel as an injectable, sustained drug delivery vehicle |
| US7780973B2 (en) | 2003-12-15 | 2010-08-24 | Ethicon Endo-Surgery, Inc. | Method and device for minimally invasive implantation of biomaterial |
| US8123757B2 (en) | 2003-12-31 | 2012-02-28 | Depuy Spine, Inc. | Inserter instrument and implant clip |
| US20050216087A1 (en) * | 2004-01-05 | 2005-09-29 | St. Francis Medical Technologies, Inc. | Disk repair structures for positioning disk repair material |
| US20050175701A1 (en) | 2004-02-10 | 2005-08-11 | Alza Corporation | Capillary moderator for osmotic delivery system |
| US8076288B2 (en) | 2004-02-11 | 2011-12-13 | Amylin Pharmaceuticals, Inc. | Hybrid polypeptides having glucose lowering activity |
| EP1718665B1 (en) | 2004-02-11 | 2013-04-10 | Amylin Pharmaceuticals, LLC | Hybrid polypeptides with selectable properties |
| CN1968700A (zh) | 2004-04-15 | 2007-05-23 | 阿尔克姆斯有限公司 | 聚合物基的持续释放装置 |
| US7456254B2 (en) | 2004-04-15 | 2008-11-25 | Alkermes, Inc. | Polymer-based sustained release device |
| WO2005112977A2 (en) | 2004-04-23 | 2005-12-01 | Pharmain, Ltd. | Compositions for treatment with glucagon-like peptide, and methods of making and using the same |
| US20050266087A1 (en) | 2004-05-25 | 2005-12-01 | Gunjan Junnarkar | Formulations having increased stability during transition from hydrophobic vehicle to hydrophilic medium |
| JP2008504249A (ja) | 2004-06-28 | 2008-02-14 | ノボ ノルディスク アクティーゼルスカブ | 糖尿病を治療するための方法 |
| US7772182B2 (en) | 2004-08-05 | 2010-08-10 | Alza Corporation | Stable suspension formulations of erythropoietin receptor agonists |
| DE112005001978B4 (de) | 2004-08-18 | 2014-01-16 | Waters Technologies Corp. (N.D.Ges.D. Staates Delaware) | Definierter Leckagepfad für Hochdruckdichtung |
| US8268791B2 (en) | 2004-08-25 | 2012-09-18 | Aegis Therapeutics, Llc. | Alkylglycoside compositions for drug administration |
| WO2006034435A2 (en) | 2004-09-21 | 2006-03-30 | Point Therapeutics, Inc. | Methods and compositions for treating glucose-associated conditions, metabolic syndrome, dyslipidemias and other conditions |
| US20080038316A1 (en) | 2004-10-01 | 2008-02-14 | Wong Vernon G | Conveniently implantable sustained release drug compositions |
| KR101506925B1 (ko) | 2004-10-01 | 2015-03-30 | 램스코르 인코포레이티드 | 편리하게 이식가능한 서방형 약물 조성물 |
| US7442682B2 (en) | 2004-10-19 | 2008-10-28 | Nitto Denko Corporation | Transepithelial delivery of peptides with incretin hormone activities |
| US8394765B2 (en) | 2004-11-01 | 2013-03-12 | Amylin Pharmaceuticals Llc | Methods of treating obesity with two different anti-obesity agents |
| ATE427759T1 (de) | 2004-11-01 | 2009-04-15 | Amylin Pharmaceuticals Inc | Behandlung von fettsucht und verbundenen erkrankungen |
| US7575579B2 (en) | 2004-11-18 | 2009-08-18 | Union Surgical, Llc | Drill guide tissue protector |
| EP1666085A1 (fr) | 2004-12-01 | 2006-06-07 | Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S) SAS | Dispositif d'injection d'un implant solide ou semi-solide |
| US20060141040A1 (en) | 2004-12-23 | 2006-06-29 | Guohua Chen | Injectable non-aqueous suspension |
| US20060142234A1 (en) | 2004-12-23 | 2006-06-29 | Guohua Chen | Injectable non-aqueous suspension |
| WO2006074051A2 (en) | 2004-12-30 | 2006-07-13 | Diakine Therapeutics, Inc. | PHARMACEUTICAL COMPOSITIONS AND METHODS FOR RESTORING β-CELL MASS AND FUNCTION |
| USD587374S1 (en) | 2005-01-14 | 2009-02-24 | Edwards Lifesciences Corporation | Sensor case |
| BRPI0606826A2 (pt) | 2005-01-24 | 2010-02-09 | Organon Nv | aplicador para inserir um implante |
| JP4876077B2 (ja) | 2005-01-24 | 2012-02-15 | ナムローゼ・フェンノートシャップ・オルガノン | インプラントを挿入するためのアプリケータ |
| CA2595457A1 (en) | 2005-01-25 | 2006-08-03 | Microchips, Inc. | Control of drug release by transient modification of local microenvironments |
| WO2006084141A2 (en) | 2005-02-03 | 2006-08-10 | Intarcia Therapeutics, Inc | Suspension formulation of interferon |
| WO2006083761A2 (en) | 2005-02-03 | 2006-08-10 | Alza Corporation | Solvent/polymer solutions as suspension vehicles |
| US20060216242A1 (en) | 2005-02-03 | 2006-09-28 | Rohloff Catherine M | Suspending vehicles and pharmaceutical suspensions for drug dosage forms |
| WO2006086727A2 (en) | 2005-02-09 | 2006-08-17 | Entelos, Inc. | Treating diabetes with glucagon-like peptide-1 secretagogues |
| EP1853627A2 (en) | 2005-02-11 | 2007-11-14 | Amylin Pharmaceuticals, Inc. | Gip analog and hybrid polypeptides with selectable properties |
| US8263545B2 (en) | 2005-02-11 | 2012-09-11 | Amylin Pharmaceuticals, Inc. | GIP analog and hybrid polypeptides with selectable properties |
| GB0504857D0 (en) | 2005-03-09 | 2005-04-13 | Imp College Innovations Ltd | Novel compounds and their effects on feeding behaviour |
| US7959938B2 (en) | 2005-03-15 | 2011-06-14 | Intarcia Therapeutics, Inc. | Polyoxaester suspending vehicles for use with implantable delivery systems |
| BRPI0606466A2 (pt) | 2005-03-31 | 2009-06-30 | Amylin Pharmaceuticals Inc | amilina e agonistas de amilina para o tratamento de doenças e distúrbios psiquiátricos |
| AU2006235183B2 (en) | 2005-04-08 | 2011-02-10 | Amylin Pharmaceuticals, Llc | Pharmaceutical formulations comprising incretin peptide and aprotic polar solvent |
| EP1874339A1 (en) | 2005-04-21 | 2008-01-09 | Gastrotech Pharma A/S | Pharmaceutical preparations of a glp-1 molecule and an anti-emetic drug |
| US7641649B2 (en) | 2005-05-06 | 2010-01-05 | Medtronic Minimed, Inc. | Reservoir support and method for infusion device |
| ES2399645T3 (es) | 2005-06-06 | 2013-04-02 | Camurus Ab | Formulaciones de análogos de GLP-1 |
| US20060280795A1 (en) | 2005-06-08 | 2006-12-14 | Dexcel Pharma Technologies, Ltd. | Specific time-delayed burst profile delivery system |
| US9447781B2 (en) | 2005-07-22 | 2016-09-20 | University Of Utah Research Foundation | Osmotically driven dispense pump and related components for use in high pressure applications |
| US20070027105A1 (en) | 2005-07-26 | 2007-02-01 | Alza Corporation | Peroxide removal from drug delivery vehicle |
| EP1922336B1 (en) | 2005-08-11 | 2012-11-21 | Amylin Pharmaceuticals, LLC | Hybrid polypeptides with selectable properties |
| WO2007022518A2 (en) | 2005-08-19 | 2007-02-22 | Amylin Pharmaceuticals, Inc. | New uses of glucoregulatory proteins |
| PT3524261T (pt) | 2005-08-19 | 2024-01-12 | Amylin Pharmaceuticals Llc | Exendina para o tratamento da diabetes e redução do peso corporal |
| HUE029798T2 (en) | 2005-11-04 | 2017-03-28 | Glaxosmithkline Llc | Methods of administering hypoglycemic agents |
| WO2007053946A1 (en) | 2005-11-09 | 2007-05-18 | Conjuchem Biotechnologies Inc. | Method of treating diabetes and/or obesity with reduced nausea side effects using an insulinotropic peptide conjugated to albumin |
| JP5096363B2 (ja) | 2005-12-16 | 2012-12-12 | ネクター セラピューティックス | Ｇｌｐ−１のポリマ複合体 |
| JP2009519949A (ja) | 2005-12-16 | 2009-05-21 | アミリン・ファーマシューティカルズ，インコーポレイテッド | 肥満症および関連する代謝性疾患の治療のための組成物および方法 |
| JP5242415B2 (ja) | 2006-01-18 | 2013-07-24 | フォアシーエイサー ファーマシューティカルズ インコーポレイテッド | 高い安定性を持つ薬理組成物 |
| JP5412273B2 (ja) | 2006-03-21 | 2014-02-12 | アミリン・ファーマシューティカルズ，リミテッド・ライアビリティ・カンパニー | ペプチド−ぺプチダーゼ阻害剤及びその使用 |
| AU2007238129A1 (en) * | 2006-04-11 | 2007-10-25 | Synthes Gmbh | Minimally invasive fixation system |
| WO2007128757A2 (en) | 2006-05-02 | 2007-11-15 | Actogenix N.V. | Microbial intestinal delivery of obesity related peptides |
| WO2007133778A2 (en) | 2006-05-12 | 2007-11-22 | Amylin Pharmaceuticals, Inc. | Methods to restore glycemic control |
| ES2351527T3 (es) | 2006-05-30 | 2011-02-07 | Intarcia Therapeutics, Inc | Modulador de flujo en dos piezas con conducto interno para un sistema osmótico de administración. |
| GB0613196D0 (en) | 2006-07-03 | 2006-08-09 | Imp Innovations Ltd | Novel compounds and their effects on feeding behaviour |
| KR20140109509A (ko) | 2006-07-11 | 2014-09-15 | 큐피에스 엘엘씨 | 펩타이드의 지속 방출 전달을 위한 의약 조성물 |
| WO2008019147A2 (en) | 2006-08-04 | 2008-02-14 | Amylin Pharmaceuticals, Inc. | Use of exendins, exendin agonists and glp-1 receptor agonists for altering the concentration of fibrinogen |
| KR101200728B1 (ko) | 2006-08-09 | 2012-11-13 | 인타르시아 세라퓨틱스 인코포레이티드 | 삼투성 전달 시스템 및 피스톤 조립체 |
| AR063120A1 (es) | 2006-10-05 | 2008-12-30 | Panacea Biotec Ltd | Composiciones inyectables de deposito y proceso para prepararlas |
| WO2008061355A1 (en) | 2006-11-24 | 2008-05-29 | Matregen Corp. | Glp-1 depot systems, and methods of manufacture and uses thereof |
| TWI428346B (zh) | 2006-12-13 | 2014-03-01 | Imp Innovations Ltd | 新穎化合物及其等對進食行為影響 |
| EP2124974B1 (en) | 2007-01-05 | 2017-03-15 | Indiana University Research and Technology Corporation | Glucagon analogs exhibiting enhanced solubility in physiological ph buffers |
| USD555589S1 (en) | 2007-01-23 | 2007-11-20 | Intec, Inc. | Battery charger and game controller cradle |
| WO2008092084A2 (en) | 2007-01-26 | 2008-07-31 | Centocor, Inc. | Injectable non-aqueous suspension with high concentration of therapeutic agent |
| US20080208194A1 (en) | 2007-02-13 | 2008-08-28 | Christine Bickenbach | Double cut shaver |
| US8262667B1 (en) | 2007-02-23 | 2012-09-11 | Holmed Corporation | Multi-diameter implant forceps |
| RU2440097C2 (ru) | 2007-04-23 | 2012-01-20 | Интарсия Терапьютикс, Инк. | Способ лечения диабета ii типа и ожирения, осмотическое устройство для доставки и способ его изготовления |
| JP5213950B2 (ja) * | 2007-04-23 | 2013-06-19 | エス・アイ・ディ・テクノロジーズ・リミテッド・ライアビリティ・カンパニー | 皮内注射のための方法および装置 |
| US9561053B2 (en) * | 2007-04-25 | 2017-02-07 | Medtronic, Inc. | Implant tool to facilitate medical device implantation |
| US8236760B2 (en) | 2007-04-27 | 2012-08-07 | Cedars-Sinsai Medical Center | Use of GLP-1 receptor agonists for the treatment of short bowel syndrome |
| WO2008139303A2 (en) | 2007-05-10 | 2008-11-20 | Cadila Pharmaceuticals Ltd. | A novel device for intradermal injection |
| EP2214580B1 (en) * | 2007-11-16 | 2013-05-22 | Synthes GmbH | Porous containment device for stabilization of vertebral compression fractures |
| WO2009100216A1 (en) | 2008-02-08 | 2009-08-13 | Qps Llc | Composition for sustained release delivery of proteins or peptides |
| CA2726861C (en) | 2008-02-13 | 2014-05-27 | Intarcia Therapeutics, Inc. | Devices, formulations, and methods for delivery of multiple beneficial agents |
| WO2009102969A1 (en) | 2008-02-14 | 2009-08-20 | Enteromedics, Inc. | Treatment of excess weight by neural downregulation in combination with compositions |
| US20110046071A1 (en) | 2008-03-05 | 2011-02-24 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | GLP-1 Receptor Agonists And Related Active Pharmaceutical Ingredients For Treatment Of Cancer |
| US20090234392A1 (en) | 2008-03-13 | 2009-09-17 | Depuy Spine, Inc. | Method for inserting a spinal fixation element using implants having guide tabs |
| CA2720280C (en) * | 2008-04-01 | 2018-02-20 | Mosamedix B.V. | Annexin a5 for reducing scar formation in wound healing |
| CN105031811B (zh) | 2008-04-04 | 2017-09-08 | 安特罗麦迪克斯公司 | 用于葡萄糖调节的方法和系统 |
| ES2552646T3 (es) | 2008-05-21 | 2015-12-01 | Amylin Pharmaceuticals, Inc. | Exendinas para disminuir el colesterol y los triglicéridos |
| US8998929B2 (en) * | 2008-07-31 | 2015-04-07 | Medtronic, Inc. | Medical device system and apparatus for guiding the placement of a subcutaneous device |
| NZ591810A (en) | 2008-09-17 | 2012-12-21 | Chiasma Inc | Pharmaceutical compositions and related methods of delivery the composition comprises a medium chain fatty acid |
| RU2510266C2 (ru) | 2008-09-30 | 2014-03-27 | Эндо Фармасьютикалз Солюшнз Инк. | Имплантируемое устройство для доставки рисперидона и способы его применения |
| US9622778B2 (en) | 2008-10-14 | 2017-04-18 | Medtronic, Inc. | Subcutaneous delivery tool |
| WO2010044867A1 (en) | 2008-10-15 | 2010-04-22 | Intarcia Therapeutics, Inc. | Highly concentrated drug particles, formulations, suspensions and uses thereof |
| EP2367503A1 (en) | 2008-11-25 | 2011-09-28 | AttenueX Technologies, Inc. | Implant with high vapor pressure medium |
| JP5328421B2 (ja) * | 2009-02-27 | 2013-10-30 | 株式会社ホギメディカル | 鉗子 |
| US20100298840A1 (en) * | 2009-05-22 | 2010-11-25 | Schwartz Lyman D | Phimosis Treatment Device and Method |
| USD638478S1 (en) | 2009-07-06 | 2011-05-24 | Performance Designed Products Llc | Video game controller accessory |
| RU87915U1 (ru) | 2009-07-20 | 2009-10-27 | Алексей Асадович Сеид-Гусейнов | Система подкожного введения лекарственных средств |
| EP2456491B1 (en) | 2009-07-23 | 2017-04-19 | Sid Technologies LLC | Intradermal injection adapter |
| US20110022165A1 (en) | 2009-07-23 | 2011-01-27 | Edwards Lifesciences Corporation | Introducer for prosthetic heart valve |
| US9358064B2 (en) * | 2009-08-07 | 2016-06-07 | Ulthera, Inc. | Handpiece and methods for performing subcutaneous surgery |
| PT2461758T (pt) | 2009-08-07 | 2017-07-05 | Ulthera Inc | Peça manual para reduzir o aparecimento da celulite |
| USD789539S1 (en) | 2015-07-09 | 2017-06-13 | Spinal Surgical Strategies, Llc | Fusion cage |
| HRP20171801T1 (hr) | 2009-09-28 | 2017-12-29 | Intarcia Therapeutics, Inc. | Brzo uspostavljanje i/ili brzo završavanje uglavnom stabilne primjene lijeka |
| RU2012123393A (ru) * | 2009-11-06 | 2013-12-20 | Зинтес Гмбх | Минимально инвазивные межостистые спейсеры (имплантаты) и способы |
| US8734467B2 (en) * | 2009-12-02 | 2014-05-27 | Valtech Cardio, Ltd. | Delivery tool for implantation of spool assembly coupled to a helical anchor |
| CN102791731B (zh) | 2009-12-16 | 2016-04-20 | 诺沃—诺迪斯克有限公司 | Glp-1类似物和衍生物 |
| AR079345A1 (es) | 2009-12-22 | 2012-01-18 | Lilly Co Eli | Analogo peptidico de oxintomodulina |
| AR079344A1 (es) | 2009-12-22 | 2012-01-18 | Lilly Co Eli | Analogo peptidico de oxintomodulina, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para tratar diabetes no insulinodependiente y/u obesidad |
| EP2538849B1 (en) * | 2010-02-23 | 2020-07-15 | Boston Scientific Scimed, Inc. | Surgical articles for treating incontinence |
| WO2011156407A2 (en) | 2010-06-09 | 2011-12-15 | Amylin Pharmaceuticals, Inc. | Glp-1 receptor agonists to treat pancre-atitis |
| USD669589S1 (en) | 2010-08-31 | 2012-10-23 | Koninklijke Philips Electronics N.V. | Blood system cartridge |
| US20120190970A1 (en) * | 2010-11-10 | 2012-07-26 | Gnanasekar Velusamy | Apparatus and method for stabilizing a needle |
| US8747412B2 (en) | 2011-02-14 | 2014-06-10 | Imds Corporation | System and method for bone anchor removal |
| US20120208755A1 (en) | 2011-02-16 | 2012-08-16 | Intarcia Therapeutics, Inc. | Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers |
| US8556915B2 (en) | 2011-05-26 | 2013-10-15 | Derm Instruments & Innovations Llc | Skin removal instrument |
| WO2013004983A1 (en) | 2011-07-04 | 2013-01-10 | Imperial Innovations Limited | Novel compounds and their effects on feeding behaviour |
| TWD149032S (zh) | 2011-10-04 | 2012-09-01 | 虹光精密工業股份有限公司 | 手持式掃描器底座 |
| ITPD20120018A1 (it) * | 2012-01-23 | 2013-07-24 | Cardiac Impulse Srl | Dispositivo di introduzione per elettrocateteri neurologici percutanei |
| CN104302236A (zh) | 2012-04-19 | 2015-01-21 | 瑞福德有限公司 | 用于去除皮肤下植入物的工具 |
| SG11201406845YA (en) | 2012-04-24 | 2014-11-27 | Urogyn B V | Bulking agent applicator for treating female urinary incontinence |
| US9241638B2 (en) | 2012-05-04 | 2016-01-26 | Pacesetter, Inc. | System and method for implanting a physiologic sensor assembly |
| AU2013268517A1 (en) * | 2012-05-29 | 2015-01-22 | National University Corporation Kochi University | Artery visualization device and artery imaging device |
| US9572970B2 (en) | 2012-06-04 | 2017-02-21 | Medtronic, Inc. | Transcutaneous implant tools, systems and methods |
| US20140058425A1 (en) * | 2012-08-27 | 2014-02-27 | Amir Porat | Manually operated surgical devices with operative portions formed of a see-through material |
| US9332995B2 (en) | 2012-09-25 | 2016-05-10 | Russo Inventions, Llc | Bone-harvesting tool |
| US9241722B2 (en) | 2012-10-08 | 2016-01-26 | Warsaw Orthopedic, Inc. | Surgical pin guide and methods of use |
| CA2896756A1 (en) | 2012-11-19 | 2014-05-22 | Braeburn Pharmaceuticals Bvba Sprl | Implantable drug delivery compositions and methods of treatment thereof |
| US20140324067A1 (en) | 2013-01-09 | 2014-10-30 | Senseonics, Incorporated | Subcutaneous tunneling and implantation tools for a disk-shaped sensor |
| US10117645B2 (en) | 2013-02-19 | 2018-11-06 | Mark Barongan | Apparatus for removing devices implanted in the body |
| WO2015017593A1 (en) * | 2013-07-30 | 2015-02-05 | Jcbd, Llc | Systems for and methods of fusing a sacroiliac joint |
| USD731630S1 (en) | 2014-04-08 | 2015-06-09 | Bootz Manufacturing Company | Shower pan |
| USD724740S1 (en) | 2014-06-05 | 2015-03-17 | Deka Products Limited Partnership | Enclosure for a peritoneal dialysis device |
| AU2015277639B2 (en) | 2014-06-16 | 2018-03-01 | Med-El Elektromedizinische Geraete Gmbh | Implant magnet insertion and removal tools |
| US20180229005A1 (en) * | 2014-09-19 | 2018-08-16 | Tao Life Sciences | Stabilization of tubes placed in the body |
| US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
| USD789540S1 (en) | 2016-01-29 | 2017-06-13 | Veterinary Implants Direct, Llc. | Orthopedic plate |
| US9931133B2 (en) | 2016-03-24 | 2018-04-03 | A.M. Surgical, Inc. | Compact endoscopic surgical device and method of use thereof |
| RU2760007C2 (ru) | 2016-05-16 | 2021-11-22 | Интарсия Терапьютикс, Инк. | Полипептиды, селективные к рецепторам глюкагона, и способы их применения |
-
2016
- 2016-06-02 CN CN202110914048.3A patent/CN113598842A/zh active Pending
- 2016-06-02 ES ES16804481T patent/ES2968262T3/es active Active
- 2016-06-02 JP JP2017562649A patent/JP6993235B2/ja not_active Expired - Fee Related
- 2016-06-02 MA MA044390A patent/MA44390A/fr unknown
- 2016-06-02 US US15/172,132 patent/US10925639B2/en active Active
- 2016-06-02 KR KR1020247009344A patent/KR20240042548A/ko not_active Withdrawn
- 2016-06-02 WO PCT/US2016/035602 patent/WO2016196851A2/en not_active Ceased
- 2016-06-02 CA CA2987766A patent/CA2987766A1/en active Pending
- 2016-06-02 AU AU2016270984A patent/AU2016270984B2/en not_active Ceased
- 2016-06-02 EP EP16804481.6A patent/EP3302354B1/en active Active
- 2016-06-02 EP EP23201398.7A patent/EP4278996A3/en not_active Withdrawn
- 2016-06-02 CN CN201680044805.3A patent/CN107920884B/zh active Active
- 2016-06-02 KR KR1020187000070A patent/KR102650751B1/ko active Active
- 2016-06-02 MX MX2017015504A patent/MX2017015504A/es unknown
- 2016-06-02 RU RU2017142338A patent/RU2730996C2/ru active
-
2017
- 2017-11-30 MX MX2023001838A patent/MX2023001838A/es unknown
- 2017-12-01 ZA ZA2017/08200A patent/ZA201708200B/en unknown
-
2020
- 2020-12-14 US US17/121,576 patent/US20210307782A1/en not_active Abandoned
-
2021
- 2021-05-25 AU AU2021203399A patent/AU2021203399B2/en not_active Ceased
- 2021-12-09 JP JP2021200063A patent/JP7223105B2/ja active Active
-
2023
- 2023-02-02 JP JP2023014473A patent/JP2023052845A/ja active Pending
- 2023-08-18 AU AU2023216875A patent/AU2023216875A1/en not_active Abandoned
-
2024
- 2024-03-07 US US18/598,763 patent/US20240260993A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2021203399B2 (en) | Implant placement and removal systems | |
| JP4575367B2 (ja) | インプラント装置とその利用法 | |
| CN106687078B (zh) | 用于治疗剂的脉络膜上施用的方法和设备 | |
| US12042615B2 (en) | Atraumatic subcutaneous medication delivery | |
| US8672889B2 (en) | Soft tissue tunneling device | |
| CN114159646B (zh) | 一种心肌填充系统 | |
| NZ776713B2 (en) | Implant placement and removal systems | |
| HK1252724B (zh) | 植入物放置和移除系统 | |
| BR112017025818B1 (pt) | Sistema para colocação de um implante e guia de colocação para uso com uma ferramenta de colocação | |
| CN205411918U (zh) | 缓释针具 | |
| US20220331573A1 (en) | Minimally traumatic trocar method for subcutaneous medication delivery | |
| HK40014920A (en) | Method and apparatus for suprachoroidal administration of therapeutic agent | |
| CN105582612A (zh) | 缓释针具 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20210531 |
|
| EEER | Examination request |
Effective date: 20210531 |
|
| EEER | Examination request |
Effective date: 20210531 |
|
| EEER | Examination request |
Effective date: 20210531 |
|
| EEER | Examination request |
Effective date: 20210531 |
|
| EEER | Examination request |
Effective date: 20210531 |
|
| EEER | Examination request |
Effective date: 20210531 |
|
| EEER | Examination request |
Effective date: 20210531 |