BR0206469A - Composição injetável para depósito - Google Patents
Composição injetável para depósitoInfo
- Publication number
- BR0206469A BR0206469A BR0206469-3A BR0206469A BR0206469A BR 0206469 A BR0206469 A BR 0206469A BR 0206469 A BR0206469 A BR 0206469A BR 0206469 A BR0206469 A BR 0206469A
- Authority
- BR
- Brazil
- Prior art keywords
- subject
- injectable depot
- depot composition
- gel
- composition
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH] (Somatotropin)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
Abstract
"COMPOSIçãO INJETáVEL PARA DEPóSITO". São fornecidas composições em gel que podem ser utilizadas como veículos para agentes benéficos quando injetados em um sujeito e que podem fornecer liberação controlada do agente benéfico com o tempo. Em particular, são descritas composições em gel que contêm um agente que torna a composição tixotrópica para facilitar a injeção do gel em um sujeito com desconforto mínimo para o sujeito.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33625401P | 2001-11-14 | 2001-11-14 | |
PCT/US2002/036717 WO2003041685A1 (en) | 2001-11-14 | 2002-11-14 | Injectable depot composition |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0206469A true BR0206469A (pt) | 2004-01-13 |
Family
ID=23315249
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0206469-3A BR0206469A (pt) | 2001-11-14 | 2002-11-14 | Composição injetável para depósito |
Country Status (16)
Country | Link |
---|---|
US (2) | US20030157178A1 (pt) |
EP (1) | EP1446099B1 (pt) |
JP (2) | JP5170935B2 (pt) |
KR (1) | KR20040065153A (pt) |
CN (1) | CN100446809C (pt) |
AU (1) | AU2009201018B2 (pt) |
BR (1) | BR0206469A (pt) |
CA (1) | CA2466642C (pt) |
DE (1) | DE60232987D1 (pt) |
ES (1) | ES2329346T3 (pt) |
IL (1) | IL161999A0 (pt) |
MX (1) | MXPA04004664A (pt) |
NO (1) | NO20033179L (pt) |
NZ (1) | NZ533434A (pt) |
WO (1) | WO2003041685A1 (pt) |
ZA (1) | ZA200306278B (pt) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE502621T1 (de) * | 2001-11-14 | 2011-04-15 | Durect Corp | Katheterinjizierbare depotzusammensetzungen und deren verwendung |
US20040001889A1 (en) * | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
NZ537955A (en) * | 2002-07-31 | 2007-10-26 | Alza Corp | Injectable depot compositions and uses thereof |
DK1539101T3 (da) | 2002-07-31 | 2009-04-27 | Alza Corp | Injicerbare, multi-modale polymere depotsammens tninger og anvendelser deraf |
KR20050088288A (ko) * | 2002-11-06 | 2005-09-05 | 알자 코포레이션 | 제어식 방출 데포 제형 |
US7731947B2 (en) | 2003-11-17 | 2010-06-08 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising an interferon particle formulation and suspending vehicle |
FR2850282B1 (fr) | 2003-01-27 | 2007-04-06 | Jerome Asius | Implant injectable a base de ceramique pour le comblement de rides, depressions cutanees et cicatrices, et sa preparation |
ES2282529T3 (es) * | 2003-02-03 | 2007-10-16 | Hans-Dietrich Dr.Techn. Polaschegg | Composicion para la prevencion de una infeccion debida a un dispositi vo permanente. |
CN1822816A (zh) * | 2003-05-30 | 2006-08-23 | 阿尔萨公司 | 可植入的弹性体储库组合物、其用途以及制备方法 |
ITMI20031302A1 (it) * | 2003-06-26 | 2004-12-27 | Mediolanum Pharmaceuticals Ltd | Uso di etanolo come plasticizzante per preparare impianti sottocutanei contenenti principi attivi termolabili dispersi in una matrice di plga. |
US20050281879A1 (en) * | 2003-11-14 | 2005-12-22 | Guohua Chen | Excipients in drug delivery vehicles |
ATE547121T1 (de) * | 2004-04-07 | 2012-03-15 | Ares Trading Sa | Flüssigformulierung für wachstumshormone |
US20050244463A1 (en) | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Sustained release intraocular implants and methods for treating ocular vasculopathies |
US8529927B2 (en) * | 2004-04-30 | 2013-09-10 | Allergan, Inc. | Alpha-2 agonist polymeric drug delivery systems |
US20060148903A1 (en) * | 2004-11-24 | 2006-07-06 | Algorx Pharmaceuticals, Inc. | Capsaicinoid gel formulation and uses thereof |
US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
EP2361630A1 (en) * | 2005-02-03 | 2011-08-31 | Intarcia Therapeutics, Inc | Implantable drug delivery device comprising particles and an osmotic pump |
WO2006083761A2 (en) | 2005-02-03 | 2006-08-10 | Alza Corporation | Solvent/polymer solutions as suspension vehicles |
US8852638B2 (en) | 2005-09-30 | 2014-10-07 | Durect Corporation | Sustained release small molecule drug formulation |
DE602007009377D1 (de) | 2006-05-30 | 2010-11-04 | Intarcia Therapeutics Inc | Zweiteiliger flussmodulator mit einem internen kanal für ein osmotisches ausgabesystem |
CN102274557B (zh) | 2006-08-09 | 2014-12-03 | 精达制药公司 | 渗透性递送系统和活塞组件 |
CN100457187C (zh) * | 2006-11-10 | 2009-02-04 | 中国人民解放军第二军医大学 | Vegf缓释注射微球支架及其制备方法和用途 |
DK2157967T3 (da) | 2007-04-23 | 2013-04-08 | Intarcia Therapeutics Inc | Suspensionsformuleringer af insulinotropiske peptider og anvendelser deraf |
CN103007288B (zh) | 2007-05-18 | 2015-02-11 | 杜雷科特公司 | 改进的贮库制剂 |
WO2008153611A2 (en) | 2007-05-25 | 2008-12-18 | Qlt Usa, Inc. | Sustained delivery formulations of risperidone compounds |
US20090181068A1 (en) * | 2008-01-14 | 2009-07-16 | Dunn Richard L | Low Viscosity Liquid Polymeric Delivery System |
US8343140B2 (en) | 2008-02-13 | 2013-01-01 | Intarcia Therapeutics, Inc. | Devices, formulations, and methods for delivery of multiple beneficial agents |
US9095506B2 (en) | 2008-11-17 | 2015-08-04 | Allergan, Inc. | Biodegradable alpha-2 agonist polymeric implants and therapeutic uses thereof |
LT2462246T (lt) | 2009-09-28 | 2017-11-27 | Intarcia Therapeutics, Inc | Esminio stacionaraus vaisto tiekimo greitas įgyvendinimas ir (arba) nutraukimas |
CN102724951A (zh) | 2009-11-09 | 2012-10-10 | 阿勒根公司 | 用于刺激毛发生长的组合物和方法 |
US9211175B2 (en) * | 2010-07-08 | 2015-12-15 | Covidien Lp | Self-detachable medical devices |
US20120208755A1 (en) | 2011-02-16 | 2012-08-16 | Intarcia Therapeutics, Inc. | Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers |
KR20150119254A (ko) | 2013-02-15 | 2015-10-23 | 알러간, 인코포레이티드 | 지속된 약물 전달 임플란트 |
US20140308352A1 (en) | 2013-03-11 | 2014-10-16 | Zogenix Inc. | Compositions and methods involving polymer, solvent, and high viscosity liquid carrier material |
CN109602692B (zh) | 2013-03-11 | 2022-11-04 | 度瑞公司 | 包含高粘度液体载体的可注射控制释放组合物 |
WO2015018461A1 (fr) * | 2013-08-09 | 2015-02-12 | Genbiotech | Compositions therapeutiques comprenant d'acide hyaluronique |
WO2015088990A1 (en) | 2013-12-09 | 2015-06-18 | Durect Corporation | Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same |
US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
CA2984494A1 (en) * | 2015-05-06 | 2016-11-10 | Synagile Corporation | Pharmaceutical suspensions containing drug particles, devices for their administration, and methods of their use |
CN113598842A (zh) | 2015-06-03 | 2021-11-05 | 因塔西亚制药公司 | 植入物放置和移除系统 |
EP3458084B1 (en) | 2016-05-16 | 2020-04-01 | Intarcia Therapeutics, Inc | Glucagon-receptor selective polypeptides and methods of use thereof |
USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
EP3565580B1 (en) | 2017-01-03 | 2024-03-06 | i2o Therapeutics, Inc. | Continuous administration of exenatide and co-adminstration of acetaminophen, ethinylestradiol or levonorgestrel |
WO2020033677A1 (en) | 2018-08-08 | 2020-02-13 | Johnson Lanny Leo | Methods of diagnosing and treating infected implants |
BR112022013784A2 (pt) | 2020-01-13 | 2022-10-11 | Durect Corp | Sistemas de distribuição de fármacos de liberação prolongada com impurezas reduzidas e métodos relacionados |
CN113304325B (zh) * | 2020-02-27 | 2022-03-11 | 四川大学 | 一种集可注射与抗菌于一体的双功能水凝胶及其制备方法和用途 |
Family Cites Families (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3773919A (en) * | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
US3797492A (en) * | 1972-12-27 | 1974-03-19 | Alza Corp | Device for dispensing product with directional guidance member |
US3923939A (en) * | 1974-06-07 | 1975-12-02 | Alza Corp | Process for improving release kinetics of a monolithic drug delivery device |
US3987790A (en) * | 1975-10-01 | 1976-10-26 | Alza Corporation | Osmotically driven fluid dispenser |
US4008719A (en) * | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
IE52535B1 (en) * | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
LU83485A1 (fr) * | 1981-07-09 | 1983-02-04 | Metallurgie Hoboken | Procede et installation pour couler une bande a oreilles en saillie laterale |
US4443340A (en) * | 1981-10-09 | 1984-04-17 | Betz Laboratories, Inc. | Control of iron induced fouling in water systems |
JPS60100516A (ja) * | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
US4623588A (en) * | 1984-02-06 | 1986-11-18 | Biotek, Inc. | Controlled release composite core coated microparticles |
US4708861A (en) * | 1984-02-15 | 1987-11-24 | The Liposome Company, Inc. | Liposome-gel compositions |
US4985404A (en) * | 1984-10-04 | 1991-01-15 | Monsanto Company | Prolonged release of biologically active polypeptides |
US4931279A (en) * | 1985-08-16 | 1990-06-05 | Bausch & Lomb Incorporated | Sustained release formulation containing an ion-exchange resin |
US4668506A (en) * | 1985-08-16 | 1987-05-26 | Bausch & Lomb Incorporated | Sustained-release formulation containing and amino acid polymer |
US4713244A (en) * | 1985-08-16 | 1987-12-15 | Bausch & Lomb Incorporated | Sustained-release formulation containing an amino acid polymer with a lower alkyl (C1 -C4) polar solvent |
US4865845A (en) * | 1986-03-21 | 1989-09-12 | Alza Corporation | Release rate adjustment of osmotic or diffusional delivery devices |
US4853218A (en) * | 1987-02-24 | 1989-08-01 | Schering Corporation | Zinc-protamine-alpha interferon complex |
US4938762A (en) * | 1987-12-16 | 1990-07-03 | Protek Ag | Reference system for implantation of condylar total knee prostheses |
US4866050A (en) * | 1988-04-27 | 1989-09-12 | Ben Amoz Daniel | Ultrasonic transdermal application of steroid compositions |
US5181914A (en) * | 1988-08-22 | 1993-01-26 | Zook Gerald P | Medicating device for nails and adjacent tissue |
US4938763B1 (en) * | 1988-10-03 | 1995-07-04 | Atrix Lab Inc | Biodegradable in-situ forming implants and method of producing the same |
US5085866A (en) * | 1988-12-02 | 1992-02-04 | Southern Research Institute | Method of producing zero-order controlled-released devices |
US5059423A (en) * | 1988-12-13 | 1991-10-22 | Alza Corporation | Delivery system comprising biocompatible beneficial agent formulation |
US5057318A (en) * | 1988-12-13 | 1991-10-15 | Alza Corporation | Delivery system for beneficial agent over a broad range of rates |
US5019400A (en) * | 1989-05-01 | 1991-05-28 | Enzytech, Inc. | Very low temperature casting of controlled release microspheres |
US5112614A (en) * | 1989-09-14 | 1992-05-12 | Alza Corporation | Implantable delivery dispenser |
US5234692A (en) * | 1990-07-11 | 1993-08-10 | Alza Corporation | Delivery device with a protective sleeve |
US5077033A (en) * | 1990-08-07 | 1991-12-31 | Mediventures Inc. | Ophthalmic drug delivery with thermo-irreversible gels of polxoxyalkylene polymer and ionic polysaccharide |
US5151093A (en) * | 1990-10-29 | 1992-09-29 | Alza Corporation | Osmotically driven syringe with programmable agent delivery |
US5137727A (en) * | 1991-06-12 | 1992-08-11 | Alza Corporation | Delivery device providing beneficial agent stability |
US5209746A (en) * | 1992-02-18 | 1993-05-11 | Alza Corporation | Osmotically driven delivery devices with pulsatile effect |
US5447725A (en) * | 1993-06-11 | 1995-09-05 | The Procter & Gamble Company | Methods for aiding periodontal tissue regeneration |
US5674292A (en) * | 1995-06-07 | 1997-10-07 | Stryker Corporation | Terminally sterilized osteogenic devices and preparation thereof |
US6235023B1 (en) * | 1995-08-15 | 2001-05-22 | Rita Medical Systems, Inc. | Cell necrosis apparatus |
US5980945A (en) * | 1996-01-16 | 1999-11-09 | Societe De Conseils De Recherches Et D'applications Scientifique S.A. | Sustained release drug formulations |
DE69705746T2 (de) * | 1996-12-20 | 2001-10-31 | Alza Corp | Injizierbare depotgelzubereitung und herstellungsverfahren |
US6193991B1 (en) * | 1997-10-29 | 2001-02-27 | Atul J. Shukla | Biodegradable delivery systems of biologically active substances |
DK1063942T3 (da) * | 1998-03-19 | 2005-11-07 | Merck & Co Inc | Flydende polymere præparater til kontrolleret frigivelse af bioaktive stoffer |
US6451346B1 (en) * | 1998-12-23 | 2002-09-17 | Amgen Inc | Biodegradable pH/thermosensitive hydrogels for sustained delivery of biologically active agents |
KR100844295B1 (ko) * | 1999-06-04 | 2008-07-07 | 알자 코포레이션 | 이식성 겔 조성물 및 이의 제조방법 |
US6423818B1 (en) * | 1999-07-30 | 2002-07-23 | Takehisa Matsuda | Coumarin endcapped absorbable polymers |
ATE502621T1 (de) * | 2001-11-14 | 2011-04-15 | Durect Corp | Katheterinjizierbare depotzusammensetzungen und deren verwendung |
US20070196415A1 (en) * | 2002-11-14 | 2007-08-23 | Guohua Chen | Depot compositions with multiple drug release rate controls and uses thereof |
NZ537955A (en) * | 2002-07-31 | 2007-10-26 | Alza Corp | Injectable depot compositions and uses thereof |
-
2002
- 2002-11-14 NZ NZ533434A patent/NZ533434A/en not_active IP Right Cessation
- 2002-11-14 CA CA2466642A patent/CA2466642C/en not_active Expired - Fee Related
- 2002-11-14 WO PCT/US2002/036717 patent/WO2003041685A1/en active Application Filing
- 2002-11-14 EP EP02784472A patent/EP1446099B1/en not_active Expired - Lifetime
- 2002-11-14 BR BR0206469-3A patent/BR0206469A/pt not_active IP Right Cessation
- 2002-11-14 KR KR10-2003-7009399A patent/KR20040065153A/ko not_active Application Discontinuation
- 2002-11-14 MX MXPA04004664A patent/MXPA04004664A/es active IP Right Grant
- 2002-11-14 ES ES02784472T patent/ES2329346T3/es not_active Expired - Lifetime
- 2002-11-14 US US10/295,159 patent/US20030157178A1/en not_active Abandoned
- 2002-11-14 DE DE60232987T patent/DE60232987D1/de not_active Expired - Lifetime
- 2002-11-14 CN CNB028267974A patent/CN100446809C/zh not_active Expired - Fee Related
- 2002-11-14 JP JP2003543572A patent/JP5170935B2/ja not_active Expired - Fee Related
-
2003
- 2003-07-11 NO NO20033179A patent/NO20033179L/no not_active Application Discontinuation
- 2003-08-13 ZA ZA2003/06278A patent/ZA200306278B/en unknown
-
2004
- 2004-05-13 IL IL16199904A patent/IL161999A0/xx unknown
-
2009
- 2009-03-13 AU AU2009201018A patent/AU2009201018B2/en not_active Ceased
-
2010
- 2010-06-23 JP JP2010142427A patent/JP2010265277A/ja active Pending
-
2013
- 2013-09-19 US US14/032,070 patent/US20140113864A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
NO20033179L (no) | 2003-09-04 |
ES2329346T3 (es) | 2009-11-25 |
CN1612725A (zh) | 2005-05-04 |
DE60232987D1 (de) | 2009-08-27 |
AU2009201018B2 (en) | 2011-09-22 |
JP2010265277A (ja) | 2010-11-25 |
US20140113864A1 (en) | 2014-04-24 |
WO2003041685A1 (en) | 2003-05-22 |
IL161999A0 (en) | 2005-11-20 |
NZ533434A (en) | 2006-11-30 |
AU2009201018A1 (en) | 2009-04-09 |
JP2005514350A (ja) | 2005-05-19 |
EP1446099A1 (en) | 2004-08-18 |
US20030157178A1 (en) | 2003-08-21 |
MXPA04004664A (es) | 2004-09-10 |
KR20040065153A (ko) | 2004-07-21 |
CA2466642A1 (en) | 2003-05-22 |
CA2466642C (en) | 2011-01-18 |
JP5170935B2 (ja) | 2013-03-27 |
NO20033179D0 (no) | 2003-07-11 |
ZA200306278B (en) | 2005-03-30 |
EP1446099B1 (en) | 2009-07-15 |
CN100446809C (zh) | 2008-12-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR0206469A (pt) | Composição injetável para depósito | |
BR0315304A (pt) | Formulações com depósito para liberação controlada | |
BR0316310A (pt) | Composições farmacêuticas tendo um veìculo modificado | |
BR0016828A (pt) | Polìmeros superabsorventes | |
ATE507816T1 (de) | Injizierbare depotzusammensetzungen und deren verwendung | |
DE60003803D1 (de) | Trockene formbare arzneistoffformulierung | |
BRPI0515316A (pt) | compostos de imidazoquinolina | |
BRPI0410953A (pt) | composições de depósito elastoméricas que podem ser implantadas, usos das mesmas e processo de produção | |
DK1162943T3 (da) | Ikke-sviende coatingpræparat | |
AR052545A1 (es) | Suspension no acuosa inyectable | |
DK0876140T3 (da) | Forbedrede kontrastmiddelopløsninger til intravasal anvendelse | |
DE69729292D1 (de) | Kurze externe führungssequenzen | |
AR049955A1 (es) | Composiciones y metodos para el tratamiento de trastornos metabolicos | |
BRPI0416590A (pt) | excipientes em veìculos de distribuição de fármacos | |
CY1107649T1 (el) | Συνδυασμος ο οποιος περιεχει ενα αντιφολικο αλας και παραγοντα ελαττωσης μεθυλομηλονικου οξεος | |
BR0315513A (pt) | Composição farmacêutica injetável, processo para preparação de composição farmacêutica, e, uso de cefquinoma em um veìculo com liberação prolongada | |
BRPI0407652A (pt) | método para acentuar a eficácia de um agente ativo, composição e método para produzir a composição | |
ES2159871T3 (es) | Composiciones de revestimiento electrodepositables y metodo para una mejor respuesta de curado. | |
BR0107544A (pt) | Composição de promoção de secreção de bile | |
ATE367828T1 (de) | Igf-enthaltende injizierbare formulierungen enthaltend succinate als puffermittel | |
BR0010499A (pt) | Agentes endoparasiticidas | |
BRPI0309768B8 (pt) | composição lubrificante substancialmente anidra | |
AR022620A1 (es) | Aroil aminoacil pirroles para ser usados en el tratamiento de dolor neuropatico | |
RS51282B (sr) | Kompozicije sa pojačanim delovanjem na poboljšanje elastičnosti | |
BRPI0400999A (pt) | Composição de esmalte de unhas, processo cosmético não terapêutico e uso de fibras revestidas |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A ANUIDADE(S). |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2103 DE 26/04/2011. |