ES2192221T3 - Monoesteres de oleato de estrogenos para el tratamiento de la obesidad o el sobrepeso. - Google Patents
Monoesteres de oleato de estrogenos para el tratamiento de la obesidad o el sobrepeso.Info
- Publication number
- ES2192221T3 ES2192221T3 ES96500140T ES96500140T ES2192221T3 ES 2192221 T3 ES2192221 T3 ES 2192221T3 ES 96500140 T ES96500140 T ES 96500140T ES 96500140 T ES96500140 T ES 96500140T ES 2192221 T3 ES2192221 T3 ES 2192221T3
- Authority
- ES
- Spain
- Prior art keywords
- overweight
- obesity
- treatment
- group
- estrone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
- C07C69/533—Monocarboxylic acid esters having only one carbon-to-carbon double bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/017—Esters of hydroxy compounds having the esterified hydroxy group bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
- C07C69/22—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety
- C07C69/28—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety esterified with dihydroxylic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
- C07C69/533—Monocarboxylic acid esters having only one carbon-to-carbon double bond
- C07C69/58—Esters of straight chain acids with eighteen carbon atoms in the acid moiety
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
- C07C69/587—Monocarboxylic acid esters having at least two carbon-to-carbon double bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
Abstract
EL ESTROGENO SE SELECCIONA DEL GRUPO QUE CONSTA DE ESTRONA, DIETILESTILBESTROL, ESTRIOL, ESTRADIOL Y ETINILESTRADIOL; EL ACIDO GRASO SE SELECCIONA DEL GRUPO QUE CONSTA DE ACIDOS OLEICOS, LINOLEICOS, LINOLENICOS, ESTEARICOS, PALMITICOS, PALMITOLEICOS Y ARAQUIDONICOS. IMITAN LA FUNCION DE MONOOLEATO DE ESTRONA, COMO UNA SEÑAL QUE INFORMA AL CEREBRO DEL TAMAÑO DE LA MASA DE TEJIDO GRASO. COMPOSICIONES PREFERIDAS PARA INYECCION INTRAVENOSA COMPRENDEN EL MONOESTER INCORPORADO EN UNA SUSPENSION LIPIDICA, PREPARADA A PARTIR DE LIPOPROTEINAS O A PARTIR DE COMPONENTES DE LIPOSOMA COMO ACEITE DE SOJA Y FOSFOLIPIDOS DE HUEVO. CUANDO SE ADMINISTRA A RATAS CON UN 15% DE TEJIDO ADIPOSO TOTAL, PRODUCEN REDUCCION DE PESO DE ALREDEDOR DEL 10%, MEDIANTE UN NUEVO E INESPERADO MECANISMO. SON UTILES PARA EL TRATAMIENTO DE OBESIDAD Y/O SOBREPESO EN MAMIFEROS, CON LAS VENTAJAS DE ALTA EFICACIA Y BAJA TOXICIDAD.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9502101 | 1995-10-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2192221T3 true ES2192221T3 (es) | 2003-10-01 |
Family
ID=8291993
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96500140T Expired - Lifetime ES2192221T3 (es) | 1995-10-30 | 1996-10-28 | Monoesteres de oleato de estrogenos para el tratamiento de la obesidad o el sobrepeso. |
Country Status (7)
Country | Link |
---|---|
US (1) | US5798348A (es) |
EP (1) | EP0771817B1 (es) |
AT (1) | ATE235505T1 (es) |
DE (1) | DE69626927T2 (es) |
DK (1) | DK0771817T3 (es) |
ES (1) | ES2192221T3 (es) |
PT (1) | PT771817E (es) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2321455A (en) | 1997-01-24 | 1998-07-29 | Norsk Hydro As | Lipophilic derivatives of biologically active compounds |
WO1999066915A2 (en) * | 1998-06-23 | 1999-12-29 | Southern Illinois University At Carbondale | Therapeutic applications of estrogenic carboxylic acids |
WO2000050067A1 (en) * | 1999-02-26 | 2000-08-31 | Saltech I Göteborg Ab | Method and composition for the regulation of hepatic and extrahepatic production of insulin-like growth factor-1 |
CA2386095A1 (en) | 1999-09-30 | 2001-04-05 | Hollis-Eden Pharmaceuticals, Inc. | Therapeutic treatment of androgen receptor driven conditions |
US7025984B1 (en) * | 2000-06-26 | 2006-04-11 | The Procter & Gamble Company | Compositions and methods for body weight management |
AU2005242170B2 (en) * | 2000-06-26 | 2008-12-18 | The Procter & Gamble Company | Compositions and methods for body weight management |
EP2135611A1 (en) | 2001-03-01 | 2009-12-23 | Hollis-Eden Pharmaceuticals Inc. | Pregn-5-en-20-yne-3,7,17-triol derivatives for use in therapy |
ES2173049B1 (es) * | 2001-03-28 | 2004-01-16 | Oleoyl Estrone Developments S | Monoester de acido graso y estrogeno como agente antidiabetico e hipolipemiante. |
US6635015B2 (en) | 2001-04-20 | 2003-10-21 | The Procter & Gamble Company | Body weight management system |
US7125568B2 (en) | 2001-08-23 | 2006-10-24 | Sung Michael T | Lipophilic drug compositions |
US6821961B2 (en) * | 2001-08-24 | 2004-11-23 | Michael P. Girouard | Monounsaturated fatty acids of at least 20 carbon atoms and perhydrocyclopentanophenanthrene nucleus combination molecules and their use as weight-loss agents |
US20040157816A1 (en) * | 2002-08-26 | 2004-08-12 | Girouard Michael P. | Monounsaturated fatty acids and perhydrocyclopentanophenanthrene nucleus combination molecules, and their precursors, and the use of all of these as weight-loss agents |
ES2186576B1 (es) * | 2001-10-11 | 2004-09-16 | Universitat De Les Illes Balears | Acido 2-hidroxioleico para utilizar como medicamento. |
AU2003294489A1 (en) * | 2002-11-20 | 2004-06-15 | Michael P. Girouard | Combination of monounsaturated fatty acids and estrogen, and their use |
US7731947B2 (en) | 2003-11-17 | 2010-06-08 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising an interferon particle formulation and suspending vehicle |
CA2515368A1 (en) | 2003-02-13 | 2004-08-26 | Luciano Rossetti | Regulation of food intake and glucose production by modulation of long-chain fatty acyl-coa levels in the hypothalamus |
CA2436650A1 (en) * | 2003-08-06 | 2005-02-06 | Naturia Inc. | Conjugated linolenic acid (clnatm) compositions: synthesis, purification and uses |
US20070014719A1 (en) | 2004-09-29 | 2007-01-18 | Reading Christopher L | Steroid analogs and characterization and treatment methods |
US20060084636A1 (en) * | 2004-10-18 | 2006-04-20 | Maria Alemany | Methods of using fatty-acid esters of estrogens and serotonin reuptake inhibiting compounds for reducing the body weight of a mammal and compositions containing the same |
US20060084637A1 (en) * | 2004-10-18 | 2006-04-20 | Maria Alemany | Methods of using fatty-acid esters of estrogens and thermogenic compounds for reducing the body weight of a mammal and compositions containing the same |
US8299025B2 (en) | 2005-02-03 | 2012-10-30 | Intarcia Therapeutics, Inc. | Suspension formulations of insulinotropic peptides and uses thereof |
US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
WO2006083761A2 (en) | 2005-02-03 | 2006-08-10 | Alza Corporation | Solvent/polymer solutions as suspension vehicles |
US7528791B2 (en) * | 2005-08-08 | 2009-05-05 | Wistron Neweb Corporation | Antenna structure having a feed element formed on an opposite surface of a substrate from a ground portion and a radiating element |
KR101106510B1 (ko) | 2006-05-30 | 2012-01-20 | 인타르시아 세라퓨틱스 인코포레이티드 | 투피스, 내부채널 삼투압 전달 시스템 유동 조절기 |
WO2008147373A2 (en) * | 2006-06-26 | 2008-12-04 | Manhattan Pharmaceuticals, Inc. | Methods and compositions for reducing body weight using an estrogen fatty ester in an oil |
KR101200728B1 (ko) | 2006-08-09 | 2012-11-13 | 인타르시아 세라퓨틱스 인코포레이티드 | 삼투성 전달 시스템 및 피스톤 조립체 |
ES2302449B1 (es) * | 2006-10-30 | 2009-06-12 | Oleoyl-Estrone Developments, S.L. | Monoesteres de estrogenos con acido linoleico conjugado y usos de los mismos. |
EP2085089A1 (en) * | 2008-02-01 | 2009-08-05 | KTB-Tumorforschungs GmbH | Phospholipids Containing omega-3-Fatty Acids for the Treatment of Overweight, Obesity and Addictive Behavior |
EP2240155B1 (en) | 2008-02-13 | 2012-06-06 | Intarcia Therapeutics, Inc | Devices, formulations, and methods for delivery of multiple beneficial agents |
HUE035862T2 (en) | 2009-09-28 | 2018-05-28 | Intarcia Therapeutics Inc | Rapid development and / or completion of substantially steady-state drug delivery |
US20120208755A1 (en) | 2011-02-16 | 2012-08-16 | Intarcia Therapeutics, Inc. | Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers |
WO2013102207A1 (en) * | 2011-12-30 | 2013-07-04 | Rosscreening, Inc. | Estrogen receptor modulators for reducing body weight |
US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
EP3302354B1 (en) | 2015-06-03 | 2023-10-04 | i2o Therapeutics, Inc. | Implant placement systems |
BR112018073511A2 (pt) | 2016-05-16 | 2019-03-26 | Intarcia Therapeutics, Inc. | polipeptídeos seletivos do receptor de glucagon e métodos de uso dos mesmos |
USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
CN110225762A (zh) | 2017-01-03 | 2019-09-10 | 因塔西亚制药公司 | 包括glp-1受体激动剂的连续施用和药物的共同施用的方法 |
US10836788B2 (en) | 2019-02-05 | 2020-11-17 | SD Chem, Inc. | Aqueous suspension compositions, formulations, and water dispersible dry compositions comprising 16alpha-bromo-3beta-hydroxy-5alpha-androstan-17-ketone and hydrates, derivatives, and analogs thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2265976A (en) * | 1937-10-25 | 1941-12-09 | Schering Corp | Tertiary alcohols of the estrane series and their derivatives and a process for their manufacture |
GB531178A (en) * | 1938-07-02 | 1940-12-31 | Chem Ind Basel | Manufacture of new esters of the oxy-stilbene series |
JPH0610127B2 (ja) * | 1985-02-09 | 1994-02-09 | ライオン株式会社 | 養毛料 |
US4617298A (en) * | 1985-10-22 | 1986-10-14 | University Of Florida | Method and compositions for weight control |
-
1996
- 1996-10-28 PT PT96500140T patent/PT771817E/pt unknown
- 1996-10-28 DE DE69626927T patent/DE69626927T2/de not_active Expired - Lifetime
- 1996-10-28 DK DK96500140T patent/DK0771817T3/da active
- 1996-10-28 AT AT96500140T patent/ATE235505T1/de not_active IP Right Cessation
- 1996-10-28 EP EP96500140A patent/EP0771817B1/en not_active Expired - Lifetime
- 1996-10-28 ES ES96500140T patent/ES2192221T3/es not_active Expired - Lifetime
- 1996-10-30 US US08/739,165 patent/US5798348A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0771817A3 (en) | 1999-04-14 |
EP0771817A2 (en) | 1997-05-07 |
US5798348A (en) | 1998-08-25 |
DK0771817T3 (da) | 2003-07-28 |
ATE235505T1 (de) | 2003-04-15 |
PT771817E (pt) | 2003-06-30 |
EP0771817B1 (en) | 2003-03-26 |
DE69626927T2 (de) | 2003-11-20 |
DE69626927D1 (de) | 2003-04-30 |
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