CA2800079C - Macrocyclic compounds as trk kinase inhibitors - Google Patents
Macrocyclic compounds as trk kinase inhibitors Download PDFInfo
- Publication number
- CA2800079C CA2800079C CA2800079A CA2800079A CA2800079C CA 2800079 C CA2800079 C CA 2800079C CA 2800079 A CA2800079 A CA 2800079A CA 2800079 A CA2800079 A CA 2800079A CA 2800079 C CA2800079 C CA 2800079C
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- Canada
- Prior art keywords
- fluoro
- heptaen
- hexaazapentacyclo
- alkyl
- oxa
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
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| US61/426,716 | 2010-12-23 | ||
| PCT/US2011/036452 WO2011146336A1 (en) | 2010-05-20 | 2011-05-13 | Macrocyclic compounds as trk kinase inhibitors |
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- 2016-11-14 US US15/350,888 patent/US9840519B2/en not_active Expired - Fee Related
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2017
- 2017-01-09 US US15/401,952 patent/US9750744B2/en not_active Expired - Fee Related
- 2017-01-09 US US15/401,839 patent/US9718822B2/en not_active Expired - Fee Related
- 2017-02-20 JP JP2017029007A patent/JP6523356B2/ja not_active Expired - Fee Related
- 2017-06-23 US US15/632,187 patent/US9902741B2/en not_active Expired - Fee Related
- 2017-07-24 HR HRP20171140TT patent/HRP20171140T1/hr unknown
- 2017-08-03 CY CY20171100835T patent/CY1119345T1/el unknown
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2018
- 2018-01-23 IL IL257104A patent/IL257104B/en active IP Right Grant
- 2018-02-20 US US15/900,019 patent/US10647730B2/en active Active
- 2018-07-25 AU AU2018208676A patent/AU2018208676B2/en not_active Ceased
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2019
- 2019-03-11 JP JP2019044025A patent/JP2019104756A/ja not_active Withdrawn
- 2019-03-22 HR HRP20190559TT patent/HRP20190559T1/hr unknown
- 2019-04-02 CY CY20191100365T patent/CY1121688T1/el unknown
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2020
- 2020-03-13 US US16/818,125 patent/US20200291026A1/en not_active Abandoned
- 2020-07-17 AU AU2020205339A patent/AU2020205339A1/en not_active Abandoned
- 2020-12-14 JP JP2020206895A patent/JP2021054840A/ja not_active Withdrawn
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