PL3786167T3 - Diarylowy związek makrocykliczny i kompozycja farmaceutyczna oraz ich zastosowanie - Google Patents
Diarylowy związek makrocykliczny i kompozycja farmaceutyczna oraz ich zastosowanieInfo
- Publication number
- PL3786167T3 PL3786167T3 PL19791600.0T PL19791600T PL3786167T3 PL 3786167 T3 PL3786167 T3 PL 3786167T3 PL 19791600 T PL19791600 T PL 19791600T PL 3786167 T3 PL3786167 T3 PL 3786167T3
- Authority
- PL
- Poland
- Prior art keywords
- pharmaceutical composition
- macrocyclic compound
- diaryl macrocyclic
- diaryl
- compound
- Prior art date
Links
- -1 Diaryl macrocyclic compound Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/16—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D515/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D515/16—Peri-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810377811 | 2018-04-25 | ||
| PCT/CN2019/083644 WO2019206069A1 (zh) | 2018-04-25 | 2019-04-22 | 一种二芳基巨环化合物、药物组合物以及其用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3786167T3 true PL3786167T3 (pl) | 2024-11-25 |
Family
ID=68294851
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL19791600.0T PL3786167T3 (pl) | 2018-04-25 | 2019-04-22 | Diarylowy związek makrocykliczny i kompozycja farmaceutyczna oraz ich zastosowanie |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US12129258B2 (pl) |
| EP (1) | EP3786167B1 (pl) |
| JP (2) | JP7128345B2 (pl) |
| CN (1) | CN111902417B (pl) |
| ES (1) | ES2989075T3 (pl) |
| PL (1) | PL3786167T3 (pl) |
| WO (1) | WO2019206069A1 (pl) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111902417B (zh) | 2018-04-25 | 2023-07-28 | 北京普祺医药科技股份有限公司 | 一种二芳基巨环化合物、药物组合物以及其用途 |
| WO2021098703A1 (zh) * | 2019-11-18 | 2021-05-27 | 南京明德新药研发有限公司 | 作为高选择性ros1抑制剂的化合物及其应用 |
| CN112824417A (zh) * | 2019-11-21 | 2021-05-21 | 上海天慈国际药业有限公司 | 一种劳拉替尼的制备方法 |
| CN113004305B (zh) * | 2019-12-19 | 2024-04-09 | 赛诺哈勃药业（成都）有限公司 | 大环化合物及其制备方法和用途 |
| CN113121568A (zh) * | 2019-12-31 | 2021-07-16 | 成都倍特药业股份有限公司 | 一种大环结构化合物的盐及其制备方法 |
| US20230219978A1 (en) * | 2020-06-04 | 2023-07-13 | Scinnohub Pharmaceutical Co., Ltd | Compound having macrocyclic structure and use thereof |
| CN114763360A (zh) * | 2021-01-15 | 2022-07-19 | 广州百霆医药科技有限公司 | 手性大环化合物作为蛋白激酶抑制剂及其用途 |
| WO2022171139A1 (zh) * | 2021-02-10 | 2022-08-18 | 北京国鸿生物医药科技有限公司 | 一种巨环化合物、药物组合物以及其用途 |
| CN116063326B (zh) * | 2021-11-02 | 2025-08-05 | 赛诺哈勃药业（成都）有限公司 | 作为蛋白激酶调节剂的含氨基大环化合物 |
| WO2024199479A1 (zh) * | 2023-03-31 | 2024-10-03 | 北京普祺医药科技股份有限公司 | 一种大环化合物、药物组合物及其用途 |
| WO2025212729A1 (en) * | 2024-04-03 | 2025-10-09 | Blossomhill Therapeutics, Inc. | Macrocyclic compounds and their use |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2350075B1 (en) | 2008-09-22 | 2014-03-05 | Array Biopharma, Inc. | Substituted imidazo[1,2b]pyridazine compounds as trk kinase inhibitors |
| KR101853026B1 (ko) | 2008-10-22 | 2018-04-27 | 어레이 바이오파마 인크. | ＴＲＫ 키나아제 억제제로서 치환된 피라졸로［１,５ａ］ 피리미딘 화합물 |
| AR077468A1 (es) | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa |
| CN105693720B (zh) | 2010-05-20 | 2019-01-18 | 阵列生物制药公司 | 作为trk激酶抑制剂的大环化合物 |
| WO2015112806A2 (en) | 2014-01-24 | 2015-07-30 | Tp Therapeutics, Inc. | Diaryl macrocycles as modulators of protein kinases |
| MX383823B (es) * | 2015-07-21 | 2025-03-14 | Turning Point Therapeutics Inc | Macrociclos de diarilo quirales y usos de los mismo. |
| CN109715165A (zh) | 2016-07-28 | 2019-05-03 | Tp生物医药公司 | 巨环激酶抑制剂 |
| MY201925A (en) | 2017-07-28 | 2024-03-23 | Turning Point Therapeutics Inc | Macrocyclic compounds and uses thereof |
| US10698033B2 (en) | 2017-12-21 | 2020-06-30 | Robert Bosch Battery Systems, Llc | Sensor fault detection using paired sample correlation |
| WO2019149131A1 (zh) | 2018-01-30 | 2019-08-08 | 上海吉倍生物技术有限公司 | 具有大环分子结构的化合物及其用途 |
| AU2019241260B2 (en) | 2018-03-28 | 2022-06-16 | Fochon Biosciences, Ltd. | Macrocyclic compounds as TRK kinases inhibitors |
| CN111902417B (zh) | 2018-04-25 | 2023-07-28 | 北京普祺医药科技股份有限公司 | 一种二芳基巨环化合物、药物组合物以及其用途 |
| CN110577549A (zh) | 2018-06-08 | 2019-12-17 | 焦玉奇 | 大环化合物 |
| CN114423762B (zh) | 2019-09-30 | 2024-03-29 | 浙江海正药业股份有限公司 | 大环类衍生物及其制备方法和用途 |
| CN115397514A (zh) | 2020-03-02 | 2022-11-25 | 特普医药公司 | 大环化合物的治疗用途 |
-
2019
- 2019-04-22 CN CN201980020599.6A patent/CN111902417B/zh active Active
- 2019-04-22 WO PCT/CN2019/083644 patent/WO2019206069A1/zh not_active Ceased
- 2019-04-22 US US17/049,734 patent/US12129258B2/en active Active
- 2019-04-22 EP EP19791600.0A patent/EP3786167B1/en active Active
- 2019-04-22 ES ES19791600T patent/ES2989075T3/es active Active
- 2019-04-22 PL PL19791600.0T patent/PL3786167T3/pl unknown
- 2019-04-22 JP JP2021508050A patent/JP7128345B2/ja active Active
-
2022
- 2022-06-22 JP JP2022100260A patent/JP2022126780A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US12129258B2 (en) | 2024-10-29 |
| CN111902417B (zh) | 2023-07-28 |
| EP3786167A1 (en) | 2021-03-03 |
| JP2022126780A (ja) | 2022-08-30 |
| EP3786167C0 (en) | 2024-08-21 |
| ES2989075T3 (es) | 2024-11-25 |
| CN111902417A (zh) | 2020-11-06 |
| US20220162218A1 (en) | 2022-05-26 |
| WO2019206069A1 (zh) | 2019-10-31 |
| JP2021519828A (ja) | 2021-08-12 |
| EP3786167B1 (en) | 2024-08-21 |
| EP3786167A4 (en) | 2021-06-09 |
| JP7128345B2 (ja) | 2022-08-30 |
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