CA2679446C - New use of glutaminyl cyclase inhibitors - Google Patents
New use of glutaminyl cyclase inhibitors Download PDFInfo
- Publication number
- CA2679446C CA2679446C CA2679446A CA2679446A CA2679446C CA 2679446 C CA2679446 C CA 2679446C CA 2679446 A CA2679446 A CA 2679446A CA 2679446 A CA2679446 A CA 2679446A CA 2679446 C CA2679446 C CA 2679446C
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- Prior art keywords
- phenyl
- mcp
- inhibitor
- dimethoxy
- inhibitors
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- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/61—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms not forming part of a nitro radical, attached to ring nitrogen atoms
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
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- Rheumatology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
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|---|---|---|---|
| US89226507P | 2007-03-01 | 2007-03-01 | |
| US60/892,265 | 2007-03-01 | ||
| US11/685,881 | 2007-03-14 | ||
| US11/685,881 US7732162B2 (en) | 2003-05-05 | 2007-03-14 | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
| PCT/EP2008/052411 WO2008104580A1 (en) | 2007-03-01 | 2008-02-28 | New use of glutaminyl cyclase inhibitors |
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| CA2679446A1 CA2679446A1 (en) | 2008-09-04 |
| CA2679446C true CA2679446C (en) | 2016-05-17 |
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| CA2679446A Active CA2679446C (en) | 2007-03-01 | 2008-02-28 | New use of glutaminyl cyclase inhibitors |
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| EP (2) | EP2117540A1 (enExample) |
| JP (1) | JP5930573B2 (enExample) |
| KR (1) | KR20090115951A (enExample) |
| CN (1) | CN101668525A (enExample) |
| AU (1) | AU2008220785B2 (enExample) |
| CA (1) | CA2679446C (enExample) |
| EA (1) | EA200901140A1 (enExample) |
| IL (1) | IL200315A (enExample) |
| MX (1) | MX2009009234A (enExample) |
| NZ (1) | NZ579310A (enExample) |
| WO (1) | WO2008104580A1 (enExample) |
| ZA (1) | ZA200905537B (enExample) |
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| US9108948B2 (en) | 2006-06-23 | 2015-08-18 | Abbvie Inc. | Cyclopropyl amine derivatives |
| CN101472887A (zh) | 2006-06-23 | 2009-07-01 | 艾博特公司 | 作为组胺h3受体调节物的环丙胺衍生物 |
| KR20140133897A (ko) * | 2007-03-01 | 2014-11-20 | 프로비오드룩 아게 | 글루타미닐 사이클라제 저해제의 신규 용도 |
| US9186353B2 (en) | 2009-04-27 | 2015-11-17 | Abbvie Inc. | Treatment of osteoarthritis pain |
| UA108742C2 (uk) | 2009-09-23 | 2015-06-10 | Фармацевтична композиція для лікування запальних захворювань, опосередкованих mcp-1 | |
| CN102947705A (zh) * | 2010-02-18 | 2013-02-27 | 前体生物药物股份公司 | 通过确定焦谷氨酸修饰的mcp-1诊断炎性疾病的方法和谷氨酰胺酰基环化酶抑制剂的筛选方法 |
| WO2012037258A1 (en) | 2010-09-16 | 2012-03-22 | Abbott Laboratories | Processes for preparing 1,2-substituted cyclopropyl derivatives |
| CN105384692B (zh) * | 2015-10-26 | 2018-06-29 | 深圳大学 | 一种谷氨酰胺酰基环化酶抑制剂 |
| CN105384691B (zh) * | 2015-10-26 | 2018-06-29 | 深圳大学 | 一种谷氨酰胺酰基环化酶抑制剂的制备方法及应用 |
| FI3658141T3 (fi) * | 2017-07-24 | 2023-03-02 | Patologisten tilojen hoitaminen suoralla tai epäsuoralla siralfa-cd47-vuorovaikutukseen kohdentamisella | |
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2008
- 2008-02-28 EA EA200901140A patent/EA200901140A1/ru unknown
- 2008-02-28 CN CN200880011673A patent/CN101668525A/zh active Pending
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- 2008-02-28 ZA ZA200905537A patent/ZA200905537B/xx unknown
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| WO2008104580A1 (en) | 2008-09-04 |
| IL200315A (en) | 2017-08-31 |
| CN101668525A (zh) | 2010-03-10 |
| JP2010520168A (ja) | 2010-06-10 |
| KR20090115951A (ko) | 2009-11-10 |
| AU2008220785B2 (en) | 2013-02-21 |
| EP2481408A2 (en) | 2012-08-01 |
| EA200901140A1 (ru) | 2010-04-30 |
| NZ579310A (en) | 2012-03-30 |
| IL200315A0 (en) | 2010-04-29 |
| JP5930573B2 (ja) | 2016-06-15 |
| AU2008220785A1 (en) | 2008-09-04 |
| CA2679446A1 (en) | 2008-09-04 |
| ZA200905537B (en) | 2010-10-27 |
| MX2009009234A (es) | 2009-12-01 |
| EP2117540A1 (en) | 2009-11-18 |
| EP2481408A3 (en) | 2013-01-09 |
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