AU2008220785B2 - New use of glutaminyl cyclase inhibitors - Google Patents
New use of glutaminyl cyclase inhibitors Download PDFInfo
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- AU2008220785B2 AU2008220785B2 AU2008220785A AU2008220785A AU2008220785B2 AU 2008220785 B2 AU2008220785 B2 AU 2008220785B2 AU 2008220785 A AU2008220785 A AU 2008220785A AU 2008220785 A AU2008220785 A AU 2008220785A AU 2008220785 B2 AU2008220785 B2 AU 2008220785B2
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- methyl
- dimethoxy
- methoxy
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/61—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms not forming part of a nitro radical, attached to ring nitrogen atoms
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89226507P | 2007-03-01 | 2007-03-01 | |
| US60/892,265 | 2007-03-01 | ||
| US11/685,881 | 2007-03-14 | ||
| US11/685,881 US7732162B2 (en) | 2003-05-05 | 2007-03-14 | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
| PCT/EP2008/052411 WO2008104580A1 (en) | 2007-03-01 | 2008-02-28 | New use of glutaminyl cyclase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2008220785A1 AU2008220785A1 (en) | 2008-09-04 |
| AU2008220785B2 true AU2008220785B2 (en) | 2013-02-21 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2008220785A Active AU2008220785B2 (en) | 2007-03-01 | 2008-02-28 | New use of glutaminyl cyclase inhibitors |
Country Status (12)
| Country | Link |
|---|---|
| EP (2) | EP2481408A3 (enExample) |
| JP (1) | JP5930573B2 (enExample) |
| KR (1) | KR20090115951A (enExample) |
| CN (1) | CN101668525A (enExample) |
| AU (1) | AU2008220785B2 (enExample) |
| CA (1) | CA2679446C (enExample) |
| EA (1) | EA200901140A1 (enExample) |
| IL (1) | IL200315A (enExample) |
| MX (1) | MX2009009234A (enExample) |
| NZ (1) | NZ579310A (enExample) |
| WO (1) | WO2008104580A1 (enExample) |
| ZA (1) | ZA200905537B (enExample) |
Families Citing this family (12)
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| US9108948B2 (en) | 2006-06-23 | 2015-08-18 | Abbvie Inc. | Cyclopropyl amine derivatives |
| US8829041B2 (en) | 2006-06-23 | 2014-09-09 | Abbvie Inc. | Cyclopropyl amine derivatives |
| BRPI0808170A2 (pt) * | 2007-03-01 | 2014-07-08 | Probiodrug Ag | Uso de inibidores de glutaminil ciclase |
| US9186353B2 (en) | 2009-04-27 | 2015-11-17 | Abbvie Inc. | Treatment of osteoarthritis pain |
| UA108742C2 (uk) | 2009-09-23 | 2015-06-10 | Фармацевтична композиція для лікування запальних захворювань, опосередкованих mcp-1 | |
| SG182615A1 (en) * | 2010-02-18 | 2012-08-30 | Probiodrug Ag | Methods of diagnosing inflammatory diseases by determining pyroglutamate-modified mcp-1 and screening methods for inhibitors of glutaminyl cyclase |
| WO2012037258A1 (en) | 2010-09-16 | 2012-03-22 | Abbott Laboratories | Processes for preparing 1,2-substituted cyclopropyl derivatives |
| CN105384691B (zh) * | 2015-10-26 | 2018-06-29 | 深圳大学 | 一种谷氨酰胺酰基环化酶抑制剂的制备方法及应用 |
| CN105384692B (zh) * | 2015-10-26 | 2018-06-29 | 深圳大学 | 一种谷氨酰胺酰基环化酶抑制剂 |
| PL3658141T3 (pl) * | 2017-07-24 | 2023-06-12 | Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis | Leczenie stanów patologicznych przez bezpośrednie i pośrednie celowanie w oddziaływanie sirpalfa - cd47 |
| KR102230832B1 (ko) * | 2019-06-17 | 2021-03-24 | (주) 메디프론디비티 | N-치환된 티오우레아 또는 우레아 유도체 및 이를 유효성분으로 함유하는 글루타미닐 사이클레이즈 활성 관련 질환의 예방 또는 치료용 약학적 조성물 |
| CA3221003A1 (en) | 2021-06-24 | 2022-12-29 | Insilico Medicine Ip Limited | Beta-lactam derivatives for the treatment of diseases |
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| WO2004098591A2 (en) * | 2003-05-05 | 2004-11-18 | Probiodrug Ag | Inhibitors of glutaminyl cyclase and their use in the treatment of neurological diseases |
| WO2005075436A2 (en) * | 2004-02-05 | 2005-08-18 | Probiodrug Ag | Novel inhibitors of glutaminyl cyclase |
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- 2008-02-28 CA CA2679446A patent/CA2679446C/en active Active
- 2008-02-28 NZ NZ579310A patent/NZ579310A/en unknown
- 2008-02-28 AU AU2008220785A patent/AU2008220785B2/en active Active
- 2008-02-28 EP EP11192085A patent/EP2481408A3/en not_active Withdrawn
- 2008-02-28 JP JP2009551208A patent/JP5930573B2/ja active Active
- 2008-02-28 WO PCT/EP2008/052411 patent/WO2008104580A1/en not_active Ceased
- 2008-02-28 KR KR1020097018475A patent/KR20090115951A/ko not_active Ceased
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| WO2004098591A2 (en) * | 2003-05-05 | 2004-11-18 | Probiodrug Ag | Inhibitors of glutaminyl cyclase and their use in the treatment of neurological diseases |
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Also Published As
| Publication number | Publication date |
|---|---|
| EP2117540A1 (en) | 2009-11-18 |
| CA2679446A1 (en) | 2008-09-04 |
| AU2008220785A1 (en) | 2008-09-04 |
| MX2009009234A (es) | 2009-12-01 |
| NZ579310A (en) | 2012-03-30 |
| JP2010520168A (ja) | 2010-06-10 |
| ZA200905537B (en) | 2010-10-27 |
| EP2481408A2 (en) | 2012-08-01 |
| JP5930573B2 (ja) | 2016-06-15 |
| IL200315A0 (en) | 2010-04-29 |
| CA2679446C (en) | 2016-05-17 |
| EP2481408A3 (en) | 2013-01-09 |
| EA200901140A1 (ru) | 2010-04-30 |
| CN101668525A (zh) | 2010-03-10 |
| KR20090115951A (ko) | 2009-11-10 |
| WO2008104580A1 (en) | 2008-09-04 |
| IL200315A (en) | 2017-08-31 |
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