CA1230186A - Cross-linked gels of hyaluronic acid and products containing such gels - Google Patents

Cross-linked gels of hyaluronic acid and products containing such gels

Info

Publication number
CA1230186A
CA1230186A CA000481055A CA481055A CA1230186A CA 1230186 A CA1230186 A CA 1230186A CA 000481055 A CA000481055 A CA 000481055A CA 481055 A CA481055 A CA 481055A CA 1230186 A CA1230186 A CA 1230186A
Authority
CA
Canada
Prior art keywords
cross
sodium hyaluronate
weight
gel
hyaluronic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000481055A
Other languages
English (en)
French (fr)
Inventor
Endre A. Balazs
Adolf Leshchiner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biomatrix Inc
Original Assignee
Biomatrix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomatrix Inc filed Critical Biomatrix Inc
Application granted granted Critical
Publication of CA1230186A publication Critical patent/CA1230186A/en
Expired legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/731Cellulose; Quaternized cellulose derivatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Birds (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA000481055A 1984-12-06 1985-05-08 Cross-linked gels of hyaluronic acid and products containing such gels Expired CA1230186A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/678,895 US4582865A (en) 1984-12-06 1984-12-06 Cross-linked gels of hyaluronic acid and products containing such gels
US678,895 1984-12-06

Publications (1)

Publication Number Publication Date
CA1230186A true CA1230186A (en) 1987-12-08

Family

ID=24724742

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000481055A Expired CA1230186A (en) 1984-12-06 1985-05-08 Cross-linked gels of hyaluronic acid and products containing such gels

Country Status (9)

Country Link
US (1) US4582865A (enExample)
JP (2) JPS61138601A (enExample)
AU (2) AU569157B2 (enExample)
CA (1) CA1230186A (enExample)
DE (2) DE3520008A1 (enExample)
FR (1) FR2574414B1 (enExample)
GB (4) GB2168067B (enExample)
IT (1) IT1187737B (enExample)
SE (2) SE460792B (enExample)

Families Citing this family (298)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0611694B2 (ja) * 1985-01-29 1994-02-16 生化学工業株式会社 皮膚化粧料
US4863907A (en) * 1984-06-29 1989-09-05 Seikagaku Kogyo Co., Ltd. Crosslinked glycosaminoglycans and their use
US5128326A (en) * 1984-12-06 1992-07-07 Biomatrix, Inc. Drug delivery systems based on hyaluronans derivatives thereof and their salts and methods of producing same
US4713448A (en) * 1985-03-12 1987-12-15 Biomatrix, Inc. Chemically modified hyaluronic acid preparation and method of recovery thereof from animal tissues
US5099013A (en) * 1985-03-12 1992-03-24 Biomatrix, Inc, Hylan preparation and method of recovery thereof from animal tissues
US5202431A (en) * 1985-07-08 1993-04-13 Fidia, S.P.A. Partial esters of hyaluronic acid
US4851521A (en) * 1985-07-08 1989-07-25 Fidia, S.P.A. Esters of hyaluronic acid
DE3684887D1 (de) * 1985-11-29 1992-05-21 Biomatrix Inc Arzneistoffabgabesysteme auf basis von hyaluronan, dessen derivaten und salzen sowie verfahren zu deren herstellung.
IT1198449B (it) * 1986-10-13 1988-12-21 F I D I Farmaceutici Italiani Esteri di alcoli polivalenti di acido ialuronico
AU610512B2 (en) * 1986-12-11 1991-05-23 Biomatrix Incorporated Improved hyaluronate-poly (ethylene oxide) mixtures
CA1327354C (en) * 1987-03-19 1994-03-01 David Cullis-Hill Anti-inflamatory compounds and compositions
US4795741A (en) * 1987-05-06 1989-01-03 Biomatrix, Inc. Compositions for therapeutic percutaneous embolization and the use thereof
GB8713662D0 (en) * 1987-06-11 1987-07-15 Skandigen Ab Hyaluronic acid derivatives
US6610669B1 (en) 1987-09-18 2003-08-26 Genzyme Corporation Water insoluble derivatives of polyanionic polysaccharides
US6174999B1 (en) 1987-09-18 2001-01-16 Genzyme Corporation Water insoluble derivatives of polyanionic polysaccharides
US5017229A (en) * 1990-06-25 1991-05-21 Genzyme Corporation Water insoluble derivatives of hyaluronic acid
US5527893A (en) * 1987-09-18 1996-06-18 Genzyme Corporation Water insoluble derivatives of polyanionic polysaccharides
US4937270A (en) * 1987-09-18 1990-06-26 Genzyme Corporation Water insoluble derivatives of hyaluronic acid
AU619760B2 (en) * 1987-12-10 1992-02-06 Genzyme Biosurgery Corporation Hylan preparation and method of recovery thereof from animal tissues
US4888016A (en) * 1988-02-10 1989-12-19 Langerman David W "Spare parts" for use in ophthalmic surgical procedures
IT1219587B (it) * 1988-05-13 1990-05-18 Fidia Farmaceutici Polisaccaridi carbossiilici autoreticolati
US5510418A (en) * 1988-11-21 1996-04-23 Collagen Corporation Glycosaminoglycan-synthetic polymer conjugates
JPH0662678B2 (ja) * 1988-11-28 1994-08-17 電気化学工業株式会社 ヒアルロン酸固定化蛋白質及びその製造方法
US4973473A (en) * 1989-06-23 1990-11-27 Revlon, Inc. Skin care preparation
US5356883A (en) * 1989-08-01 1994-10-18 Research Foundation Of State University Of N.Y. Water-insoluble derivatives of hyaluronic acid and their methods of preparation and use
CA1340994C (en) * 1989-09-21 2000-05-16 Rudolf Edgar Dr. Falk Treatment of conditions and disease
US5153174A (en) * 1989-10-30 1992-10-06 Union Carbide Chemicals & Plastics Inc. Polymer mixtures useful in skin care
CA2086014A1 (en) * 1990-07-03 1992-01-04 CHARLES D. kELMAN Collagen-based viscoelastic solution for visco-surgery
US5143724A (en) * 1990-07-09 1992-09-01 Biomatrix, Inc. Biocompatible viscoelastic gel slurries, their preparation and use
US5246698A (en) * 1990-07-09 1993-09-21 Biomatrix, Inc. Biocompatible viscoelastic gel slurries, their preparation and use
US5824658A (en) * 1990-09-18 1998-10-20 Hyal Pharmaceutical Corporation Topical composition containing hyaluronic acid and NSAIDS
US5990096A (en) * 1990-09-18 1999-11-23 Hyal Pharmaceutical Corporation Formulations containing hyaluronic acid
US5639738A (en) * 1992-02-20 1997-06-17 Hyal Pharmaceutical Corporation Treatment of basal cell carcinoma and actinic keratosis employing hyaluronic acid and NSAIDs
CA2061703C (en) * 1992-02-20 2002-07-02 Rudolf E. Falk Formulations containing hyaluronic acid
US5910489A (en) * 1990-09-18 1999-06-08 Hyal Pharmaceutical Corporation Topical composition containing hyaluronic acid and NSAIDS
US5219360A (en) * 1991-05-10 1993-06-15 Fortis Research Corporation Mammary prosthesis fill and method of making same
EP0516026A1 (en) * 1991-05-28 1992-12-02 Takeda Chemical Industries, Ltd. Hydrogel and method of producing same
US5234914A (en) * 1991-06-11 1993-08-10 Patent Biopharmaceutics, Inc. Methods of treating hemorrhoids and anorecial disease
US5817644A (en) * 1991-07-03 1998-10-06 Hyal Pharmaceutical Corporation Targeting of dosages of medicine and therapeutic agents
US6103704A (en) * 1991-07-03 2000-08-15 Hyal Pharmaceutical Corporation Therapeutic methods using hyaluronic acid
US5977088A (en) * 1991-07-03 1999-11-02 Hyal Pharmaceutical Corporation Formulations containing hyaluronic acid
WO1994007505A1 (en) * 1991-07-03 1994-04-14 Norpharmco Inc. Use of hyaluronic acid and forms to prevent arterial restenosis
US5792753A (en) * 1991-07-03 1998-08-11 Hyal Pharmaceutical Corporation Compositions comprising hyaluronic acid and prostaglandin-synthesis-inhibiting drugs
US6022866A (en) * 1991-07-03 2000-02-08 Hyal Pharmaceutical Corporation Use of hyaluronic acid and forms to prevent arterial restenosis
US5990095A (en) * 1991-07-03 1999-11-23 Hyal Pharmaceutical Corporation Use of hyaluronic acid and forms to prevent arterial restenosis
JPH0539480U (ja) * 1991-10-31 1993-05-28 ジユーキ株式会社 ミシンの針棒
AU636544B1 (en) * 1991-11-27 1993-04-29 Lignyte Co., Ltd. Water insoluble biocompatible hyaluronic acid polyion complex and method of making the same
DE4200080A1 (de) * 1992-01-03 1993-09-30 Reinmueller Johannes Pharmazeutische Zusammensetzung zur Wund-, Narben- und Keloidbehandlung
CA2072918A1 (en) * 1992-02-14 1993-08-15 Jian Qin Modified polysaccharides having improved absorbent properties and process for the preparation thereof
CA2061567C (en) * 1992-02-20 1998-02-03 Rudolf E. Falk Use of hyaluronic acid to repair ischemia reperfusion damage
US6147059A (en) * 1992-02-20 2000-11-14 Hyal Pharmaceutical Corporation Formulations containing hyaluronic acid
US6218373B1 (en) 1992-02-20 2001-04-17 Hyal Pharmaceutical Corporation Formulations containing hyaluronic acid
US6114314A (en) * 1992-02-21 2000-09-05 Hyal Pharmaceutical Corp. Formulations containing hyaluronic acid
US5767106A (en) * 1992-02-21 1998-06-16 Hyal Pharmaceutical Corporation Treatment of disease and conditions associated with macrophage infiltration
ATE171616T1 (de) * 1992-05-15 1998-10-15 Shiseido Co Ltd Äusserliches hautpräparat
IT1260154B (it) * 1992-07-03 1996-03-28 Lanfranco Callegaro Acido ialuronico e suoi derivati in polimeri interpenetranti (ipn)
US5633001A (en) * 1993-03-19 1997-05-27 Medinvent Composition and a method for tissue augmentation
US5437867A (en) * 1993-03-19 1995-08-01 Collaborative Laboratories Solubilizing, thickening and emulsifying cosmetic composition and process for preparation of same
US5531716A (en) * 1993-09-29 1996-07-02 Hercules Incorporated Medical devices subject to triggered disintegration
US5616568A (en) * 1993-11-30 1997-04-01 The Research Foundation Of State University Of New York Functionalized derivatives of hyaluronic acid
US5585361A (en) 1994-06-07 1996-12-17 Genzyme Corporation Methods for the inhibition of platelet adherence and aggregation
US6294202B1 (en) 1994-10-06 2001-09-25 Genzyme Corporation Compositions containing polyanionic polysaccharides and hydrophobic bioabsorbable polymers
US5690961A (en) * 1994-12-22 1997-11-25 Hercules Incorporated Acidic polysaccharides crosslinked with polycarboxylic acids and their uses
US5498705A (en) * 1995-02-22 1996-03-12 Kimberly-Clark Corporation Modified polysaccharides having improved absorbent properties and process for the preparation thereof
US5612321A (en) * 1995-06-22 1997-03-18 Hercules Incorporated Antioxidant grafted polysaccharides
US5827937A (en) * 1995-07-17 1998-10-27 Q Med Ab Polysaccharide gel composition
US5897880A (en) * 1995-09-29 1999-04-27 Lam Pharmaceuticals, Llc. Topical drug preparations
AU7609896A (en) 1995-11-07 1997-05-29 Fusion Medical Technologies, Inc. Methods and articles for fusing polysaccharide-containing matrix layers to tissue
US6132462A (en) * 1995-12-22 2000-10-17 Santen Pharmaceutical Co., Ltd. Copolymers formed from three components and intraocular lenses made thereof
SE9601368D0 (sv) * 1996-04-11 1996-04-11 Pharmacia Biotech Ab Process for the production of a porous cross-linked polysaccharide gel
US6060534A (en) 1996-07-11 2000-05-09 Scimed Life Systems, Inc. Medical devices comprising ionically and non-ionically crosslinked polymer hydrogels having improved mechanical properties
US6368356B1 (en) 1996-07-11 2002-04-09 Scimed Life Systems, Inc. Medical devices comprising hydrogel polymers having improved mechanical properties
AU736876B2 (en) 1996-12-06 2001-08-02 Amgen, Inc. Combination therapy using an IL-1 inhibitor for treating IL-1 mediated diseases
US6294170B1 (en) 1997-08-08 2001-09-25 Amgen Inc. Composition and method for treating inflammatory diseases
GB2322864A (en) * 1997-03-07 1998-09-09 Polybiomed Ltd Gel for application to the human or animal body
US6709873B1 (en) * 1997-04-09 2004-03-23 Isodiagnostika Inc. Method for production of antibodies to specific sites of rapamycin
EP1004597A4 (en) * 1997-05-28 2002-06-05 Tapic Int Co Ltd COLLAGEN GEL
US5945457A (en) * 1997-10-01 1999-08-31 A.V. Topchiev Institute Of Petrochemical Synthesis, Russian Academy Of Science Process for preparing biologically compatible polymers and their use in medical devices
US5897988A (en) * 1998-01-21 1999-04-27 Yale University Process and system for selection of mature sperm by surface membrane determinants for assisted reproduction
PT939086E (pt) * 1998-02-27 2004-07-30 Stichting Hippomedics Processo para produzir o acido hialuronico reticulado
US6630457B1 (en) * 1998-09-18 2003-10-07 Orthogene Llc Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same
IT1303738B1 (it) * 1998-11-11 2001-02-23 Aquisitio S P A Processo di reticolazione di polisaccaridi carbossilati.
US7375096B1 (en) * 1998-12-04 2008-05-20 California Institute Of Technology Method of preparing a supramolecular complex containing a therapeutic agent and a multi-dimensional polymer network
JP2002532573A (ja) * 1998-12-16 2002-10-02 エスシーエイ・ハイジーン・プロダクツ・ゼイスト・ベー・ブイ 酸性の超吸収性ポリサッカライド
GB9902412D0 (en) * 1999-02-03 1999-03-24 Fermentech Med Ltd Process
GB9902652D0 (en) 1999-02-05 1999-03-31 Fermentech Med Ltd Process
NZ513517A (en) * 1999-02-19 2003-08-29 Denki Kagaku Kogyo Kk Hyaluronic acid gel composition containing a polymer for use as a wound dressing
US6472379B1 (en) 1999-03-15 2002-10-29 Trustees Of Boston University Angiogenesis inhibition
US20040048021A1 (en) * 1999-03-19 2004-03-11 Wan Barbara Y. F. Surface modification of substrates
WO2000059490A2 (en) * 1999-04-06 2000-10-12 Genzyme Corporation Immunomodulating composition for use especially in the treatment of inflammations, infections and surgical adhesions
US6288043B1 (en) * 1999-06-18 2001-09-11 Orquest, Inc. Injectable hyaluronate-sulfated polysaccharide conjugates
ES2223583T3 (es) 1999-07-28 2005-03-01 United States Surgical Corporation Barrera antiadherente de acido hialuronico.
KR100721752B1 (ko) 2000-01-24 2007-05-25 쿠라레 메디카루 가부시키가이샤 수팽윤성 고분자 겔 및 그 제조법
US6521223B1 (en) * 2000-02-14 2003-02-18 Genzyme Corporation Single phase gels for the prevention of adhesions
US6749865B2 (en) * 2000-02-15 2004-06-15 Genzyme Corporation Modification of biopolymers for improved drug delivery
KR100375299B1 (ko) 2000-10-10 2003-03-10 주식회사 엘지생명과학 히알루론산의 가교결합형 아마이드 유도체와 이의 제조방법
AU2002223995B2 (en) * 2000-11-14 2006-05-11 N.V.R. Labs Inc. Cross-linked hyaluronic acid-laminin gels and use thereof in cell culture and medical implants
CA2437417C (en) * 2001-02-22 2016-07-26 Anika Therapeutics, Inc. Thiol-modified hyaluronan
US20020172712A1 (en) * 2001-03-19 2002-11-21 Alan Drizen Antiemetic, anti-motion sustained release drug delivery system
US6913765B2 (en) 2001-03-21 2005-07-05 Scimed Life Systems, Inc. Controlling resorption of bioresorbable medical implant material
US8580290B2 (en) * 2001-05-08 2013-11-12 The Board Of Regents Of The University Of Oklahoma Heparosan-based biomaterials and coatings and methods of production and use thereof
US20030216758A1 (en) * 2001-12-28 2003-11-20 Angiotech Pharmaceuticals, Inc. Coated surgical patches
AU2003221078A1 (en) * 2002-04-08 2003-10-20 Denki Kagaku Kogyo Kabushiki Kaisha Therapeutic composition for bone infectious disease
US8313760B2 (en) * 2002-05-24 2012-11-20 Angiotech International Ag Compositions and methods for coating medical implants
CN101134119A (zh) * 2002-05-24 2008-03-05 血管技术国际股份公司 用于涂覆医用植入物的组合物和方法
DE10223310A1 (de) * 2002-05-24 2003-12-11 Biotronik Mess & Therapieg Verfahren zum Beschichten von Implantaten mit einer Polysaccharid-Lage
WO2004037164A2 (en) * 2002-06-21 2004-05-06 University Of Utah Research Foundation Crosslinked compounds and methods of making and using thereof
US7034127B2 (en) * 2002-07-02 2006-04-25 Genzyme Corporation Hydrophilic biopolymer-drug conjugates, their preparation and use
US7338433B2 (en) * 2002-08-13 2008-03-04 Allergan, Inc. Remotely adjustable gastric banding method
JP4425791B2 (ja) * 2002-08-16 2010-03-03 電気化学工業株式会社 分離型関節症治療用注入剤
BR0306183A (pt) * 2002-08-28 2004-10-19 Inamed Medical Products Corp Dispositivo de enfaixamento gástrico resistente à fadiga
CA2497792C (en) 2002-09-06 2014-08-05 Insert Therapeutics, Inc. Cyclodextrin-based polymers for therapeutics delivery
DE10252816B4 (de) * 2002-11-13 2008-02-14 Schwan-Stabilo Cosmetics Gmbh & Co. Kg Kosmetische Zubereitung, sowie ein Verfahren zu ihrer Herstellung und ihre Verwendung
JP4636883B2 (ja) * 2002-11-21 2011-02-23 中外製薬株式会社 薬物徐放担体
TWI251596B (en) * 2002-12-31 2006-03-21 Ind Tech Res Inst Method for producing a double-crosslinked hyaluronate material
LT5098B (lt) 2003-03-28 2004-01-26 Alvyda GUDELEVI�I�T� Kremų kompozicijos senstančiai odai
FR2861734B1 (fr) 2003-04-10 2006-04-14 Corneal Ind Reticulation de polysaccharides de faible et forte masse moleculaire; preparation d'hydrogels monophasiques injectables; polysaccharides et hydrogels obtenus
AU2003901834A0 (en) 2003-04-17 2003-05-01 Clearcoll Pty Ltd Cross-linked polysaccharide compositions
JP2004323454A (ja) * 2003-04-25 2004-11-18 Chisso Corp 薬剤
CA2525788A1 (en) * 2003-05-15 2005-01-06 University Of Utah Research Foundation Anti-adhesion composites and methods of use thereof
ES2226567B1 (es) * 2003-06-20 2006-07-01 Universidad De Santiago De Compostela Nanoparticulas de acido hialuronico.
DE10328816A1 (de) 2003-06-21 2005-01-05 Biotronik Meß- und Therapiegeräte GmbH & Co. Ingenieurbüro Berlin Implantierbare Stimulationselektrode mit einer Beschichtung zur Erhöhung der Gewebsverträglichkeit
DE10328815A1 (de) * 2003-06-21 2005-01-05 Biotronik Meß- und Therapiegeräte GmbH & Co. Ingenieurbüro Berlin Beschichtungssystem für Implantate zur Erhöhung der Gewebsverträglichkeit
ES2232287B1 (es) * 2003-07-04 2006-11-01 Advanced In Vitro Cell Technologies, S.L. Nanoparticulas de derivados polioxietilenados.
US20060246137A1 (en) * 2003-07-30 2006-11-02 Laurence Hermitte Complex matrix for biomedical use
ES2406555T3 (es) * 2003-10-29 2013-06-07 Teijin Limited Compuesto de ácido hialurónico, hidrogel del mismo y material para tratar articulaciones
JP2007513650A (ja) * 2003-11-20 2007-05-31 アンジオテック インターナショナル アーゲー 移植可能なセンサーおよび移植可能なポンプならびに瘢痕化抑制剤
US20080176205A1 (en) * 2003-12-04 2008-07-24 University Of Utah Research Foundation Process and Formulation to Improve Viability of Stored Cells and Tissue
US8524213B2 (en) * 2003-12-30 2013-09-03 Genzyme Corporation Polymeric materials, their preparation and use
WO2005066215A1 (en) * 2003-12-30 2005-07-21 Genzyme Corporation Cohesive gels form cross-linked hyaluronan and/or hylan, their preparation and use
WO2005072195A2 (en) 2004-01-23 2005-08-11 Inamed Medical Products Corporation Releasably-securable one-piece adjustable gastric band
EP2145610A1 (en) * 2004-03-08 2010-01-20 Allergan Medical S.A. Closure system for tubular organs
AU2005223678B2 (en) * 2004-03-17 2010-08-26 Genzyme Corporation Anti-adhesion spraying
WO2005094257A2 (en) * 2004-03-18 2005-10-13 Inamed Medical Products Corporation Apparatus and method for volume adjustment of intragastric balloons
BRPI0510477B1 (pt) 2004-04-28 2023-01-17 Angiotech Biomaterials Corporation Método para formar um gel e dispositivo para uso em aplicações médicas
ES2246695B1 (es) * 2004-04-29 2007-05-01 Instituto Cientifico Y Tecnologico De Navarra, S.A. Composicion estimuladora de la respuesta inmunitaria que comprende nanoparticulas a base de un copolimero de metil vinil eter y anhidrido maleico.
ES2246694B1 (es) * 2004-04-29 2007-05-01 Instituto Cientifico Y Tecnologico De Navarra, S.A. Nanoparticulas pegiladas.
EP1753787B1 (en) * 2004-05-20 2016-10-19 Mentor Worldwide LLC Method of covalently linking hyaluronan and chitosan
EP1750769B1 (en) * 2004-05-20 2013-01-23 Mentor Worldwide LLC Methods for making injectable polymer hydrogels
ITMI20041373A1 (it) 2004-07-09 2004-10-09 Lima Lto S P A N-metil-ammidi di carbossimetilcellulosa acido alginico o carbossimetalamido
JP5060131B2 (ja) 2004-09-07 2012-10-31 中外製薬株式会社 水溶性ヒアルロン酸修飾物の製造方法
EP1818344A4 (en) * 2004-11-15 2012-04-18 Shiseido Co Ltd METHOD FOR SYNTHESIZING RETICULATED HYALURONIC ACID GEL
US8481080B2 (en) 2004-11-24 2013-07-09 Novozymes Biopolymer A/S Method of cross-linking hyaluronic acid with divinulsulfone
CA2744999A1 (en) * 2004-12-30 2006-07-13 Genzyme Corporation Regimens for intra-articular viscosupplementation
AU2005100176A4 (en) * 2005-03-01 2005-04-07 Gym Tv Pty Ltd Garbage bin clip
US8251888B2 (en) 2005-04-13 2012-08-28 Mitchell Steven Roslin Artificial gastric valve
DE102005030614B4 (de) * 2005-06-30 2014-05-08 Biotissue Ag Zellfreies Transplantat, dessen Verwendung, Verfahren zu dessen Herstellung, dabei hergestellte Matrix mit Gel und Verfahren zur Herstellung dieser Matrix mit Gel
ES2440240T3 (es) * 2005-08-04 2014-01-28 Teijin Limited Derivado de celulosa
EP1937701A4 (en) * 2005-09-02 2009-09-16 Colbar Lifescience Ltd CROSS-LINKED POLYSACCHARIDE AND PROTEIN MATRICES AND METHOD FOR THE PRODUCTION THEREOF
JP2009508596A (ja) 2005-09-19 2009-03-05 ヒストジェニックス コーポレイション 細胞支持基材及びその調製方法
EP1968499A1 (en) 2005-12-14 2008-09-17 Anika Therapeutics Inc. Bioabsorbable implant of hyaluronic acid derivative for treatment of osteochondral and chondral defects
WO2007070547A2 (en) * 2005-12-14 2007-06-21 Anika Therapeutics, Inc. Treatment of arthritis and other musculoskeletal disorders with crosslinked hyaluronic acid
US7798954B2 (en) 2006-01-04 2010-09-21 Allergan, Inc. Hydraulic gastric band with collapsible reservoir
US8043206B2 (en) 2006-01-04 2011-10-25 Allergan, Inc. Self-regulating gastric band with pressure data processing
EP2492285A1 (en) 2006-03-07 2012-08-29 ProChon Biotech Ltd. Hydrazido derivatives of hyaluronic acid
US7674781B2 (en) * 2006-04-28 2010-03-09 Heather Sheardown Hyaluronic acid-retaining polymers
ITMI20061726A1 (it) * 2006-09-11 2008-03-12 Fidia Farmaceutici Derivati crosslinkati a base di acido ialuronico reticolato via click chemistry
AU2007295894B2 (en) * 2006-09-13 2013-10-17 Enhance Skin Products, Inc. Cosmetic composition for the treatment of skin and methods thereof
JP5030219B2 (ja) * 2007-07-19 2012-09-19 眞知子 瀧上 カルボキシメチルセルロースアルカリ塩のゲルの製造方法及びそれによって得られたカルボキシメチルセルロースアルカリ塩のゲル
DE102006047346A1 (de) * 2006-10-06 2008-04-10 Transtissue Technologies Gmbh Matrix-Gel-Transplantat ohne Zellen
EP2106263B1 (en) * 2007-01-04 2016-12-21 Hepacore Ltd. Water soluble reactive derivatives of carboxy polysaccharides and fibrinogen conjugates thereof
US20080176958A1 (en) 2007-01-24 2008-07-24 Insert Therapeutics, Inc. Cyclodextrin-based polymers for therapeutics delivery
US8529951B1 (en) 2007-02-21 2013-09-10 Anand Ramamurthi Elastogenic cues and methods for using same
US8987230B2 (en) * 2007-05-01 2015-03-24 National University Corporation Tokyo Medical And Dental University Hybrid gel comprising chemically crosslinked hyaluronic acid derivative and pharmaceutical composition comprising the same
BRPI0811784A2 (pt) * 2007-05-23 2011-05-10 Allergan Inc colÁgeno reticulado e uso do mesmo
US8658148B2 (en) 2007-06-22 2014-02-25 Genzyme Corporation Chemically modified dendrimers
FR2918377B1 (fr) 2007-07-05 2010-10-08 Estelle Piron Gel co-reticule de polysaccharides
US20110077737A1 (en) * 2007-07-30 2011-03-31 Allergan, Inc. Tunably Crosslinked Polysaccharide Compositions
US8318695B2 (en) 2007-07-30 2012-11-27 Allergan, Inc. Tunably crosslinked polysaccharide compositions
US8697044B2 (en) * 2007-10-09 2014-04-15 Allergan, Inc. Crossed-linked hyaluronic acid and collagen and uses thereof
BRPI0819075A2 (pt) 2007-11-16 2014-10-07 Vicept Therapeutics Inc Método para tratar púrpura em um indivíduo e método para diminuir a púrpura em um indivíduo antes de um procedimento cirúrgico
US8394782B2 (en) * 2007-11-30 2013-03-12 Allergan, Inc. Polysaccharide gel formulation having increased longevity
US20090143348A1 (en) * 2007-11-30 2009-06-04 Ahmet Tezel Polysaccharide gel compositions and methods for sustained delivery of drugs
US8394784B2 (en) 2007-11-30 2013-03-12 Allergan, Inc. Polysaccharide gel formulation having multi-stage bioactive agent delivery
FR2924615B1 (fr) * 2007-12-07 2010-01-22 Vivacy Lab Hydrogel cohesif biodegradable.
CN101878230B (zh) * 2007-12-19 2012-11-21 赢创高施米特有限公司 乳液中的交联透明质酸
RU2366666C1 (ru) * 2007-12-20 2009-09-10 Институт синтетических полимерных материалов (ИСПМ) им. Н.С. Ениколопова РАН Способ получения сшитых солей гиалуроновой кислоты в водной среде
US7763268B2 (en) * 2008-01-18 2010-07-27 The Research Foundation Of State University Of New York Load bearing hydrogel implants
RU2386640C2 (ru) * 2008-06-25 2010-04-20 Институт синтетических полимерных материалов (ИСПМ) им. Н.С. Ениколопова РАН Способ получения модифицированной рибофлавином сшитой соли гиалуроновой кислоты
RU2386641C2 (ru) * 2008-07-09 2010-04-20 Институт синтетических полимерных материалов (ИСПМ) им. Н.С. Ениколопова РАН Способ получения модифицированной ретинолом сшитой соли гиалуроновой кислоты
RU2387670C1 (ru) * 2008-07-30 2010-04-27 Институт синтетических полимерных материалов (ИСПМ) им. Н.С. Ениколопова РАН Способ получения модифицированной фолиевой кислотой сшитой соли гиалуроновой кислоты
RU2387671C1 (ru) * 2008-07-30 2010-04-27 Институт синтетических полимерных материалов (ИСПМ) им. Н.С. Ениколопова РАН Способ получения модифицированной витаминами сшитой соли гиалуроновой кислоты
US8450475B2 (en) 2008-08-04 2013-05-28 Allergan, Inc. Hyaluronic acid-based gels including lidocaine
ES2658609T3 (es) 2008-09-02 2018-03-12 Tautona Group Lp Hilos de ácido hialurónico y/o derivados de los mismos, métodos para fabricar los mismos, y usos de los mismos
TWI387620B (zh) * 2008-09-23 2013-03-01 Scivision Biotech Inc 交聯透明質酸之製造方法
WO2010038231A1 (en) 2008-10-02 2010-04-08 L.R.R.& D. Ltd. Interface layer wound dressing
US20100305397A1 (en) * 2008-10-06 2010-12-02 Allergan Medical Sarl Hydraulic-mechanical gastric band
EP2362762A1 (en) * 2008-10-06 2011-09-07 Allergan Medical Sàrl Mechanical gastric band with cushions
CN101721349B (zh) 2008-10-16 2011-07-20 常州百瑞吉生物医药有限公司 可注射原位交联水凝胶及其制备方法和用途
US20100185049A1 (en) 2008-10-22 2010-07-22 Allergan, Inc. Dome and screw valves for remotely adjustable gastric banding systems
CZ301555B6 (cs) 2008-11-06 2010-04-14 Cpn S. R. O. Zpusob prípravy DTPA sítovaných derivátu kyseliny hyaluronové a jejich modifikace
US8679470B2 (en) 2008-11-28 2014-03-25 Luromed Llc Composition using cross-linked hyaluronic acid for topical cosmetic and therapeutic applications
JP2010202522A (ja) * 2009-02-27 2010-09-16 Shiseido Co Ltd 耐塩性増粘剤及びそれを配合した化粧料
ES2621380T3 (es) * 2009-04-02 2017-07-03 Allergan, Inc. Hidrogeles con forma de cabello para aumento de tejidos blandos
US9371402B2 (en) 2009-04-09 2016-06-21 Scivision Biotech Inc. Method for producing cross-linked hyaluronic acid
US20110184229A1 (en) * 2009-05-01 2011-07-28 Allergan, Inc. Laparoscopic gastric band with active agents
US20100280310A1 (en) * 2009-05-01 2010-11-04 Allergan, Inc. Laparoscopic Gastric Band With Active Agents
IT1399351B1 (it) 2009-06-16 2013-04-16 Fidia Farmaceutici Procedimento per la sintesi di coniugati di glicosamminoglicani (gag) con molecole biologicamente attive, coniugati polimerici e usi relativi
WO2011014432A1 (en) 2009-07-30 2011-02-03 Carbylan Biosurgery, Inc. Modified hyaluronic acid polymer compositions and related methods
US20110137112A1 (en) * 2009-08-28 2011-06-09 Allergan, Inc. Gastric band with electric stimulation
WO2011031400A2 (en) * 2009-08-28 2011-03-17 Allergan, Inc. Gastric band with electric stimulation
US8273725B2 (en) 2009-09-10 2012-09-25 Genzyme Corporation Stable hyaluronan/steroid formulation
US8247390B2 (en) * 2009-09-28 2012-08-21 Luromed Llc Modified hydrophilic polymers containing hydrophobic groups
CN107261150A (zh) * 2009-11-23 2017-10-20 布鲁林克医药品公司 用于传递治疗剂的基于环糊精的聚合物
US20110171311A1 (en) * 2010-01-13 2011-07-14 Allergan Industrie, Sas Stable hydrogel compositions including additives
US9114188B2 (en) 2010-01-13 2015-08-25 Allergan, Industrie, S.A.S. Stable hydrogel compositions including additives
US20110172180A1 (en) 2010-01-13 2011-07-14 Allergan Industrie. Sas Heat stable hyaluronic acid compositions for dermatological use
US20110171286A1 (en) * 2010-01-13 2011-07-14 Allergan, Inc. Hyaluronic acid compositions for dermatological use
US8758221B2 (en) * 2010-02-24 2014-06-24 Apollo Endosurgery, Inc. Source reservoir with potential energy for remotely adjustable gastric banding system
US8840541B2 (en) * 2010-02-25 2014-09-23 Apollo Endosurgery, Inc. Pressure sensing gastric banding system
JP5749283B2 (ja) * 2010-03-12 2015-07-15 アラーガン・アンデュストリー・ソシエテ・パール・アクシオン・サンプリフィエAllergan Industrie Sas 皮膚状態を改善するための流体組成物
ES2585388T5 (es) 2010-03-22 2019-08-08 Allergan Inc Hidrogeles reticulados de polisacárido y proteína-polisacárido para aumento de tejido blando
US9028394B2 (en) 2010-04-29 2015-05-12 Apollo Endosurgery, Inc. Self-adjusting mechanical gastric band
US9044298B2 (en) 2010-04-29 2015-06-02 Apollo Endosurgery, Inc. Self-adjusting gastric band
US20110270024A1 (en) 2010-04-29 2011-11-03 Allergan, Inc. Self-adjusting gastric band having various compliant components
US20110270025A1 (en) 2010-04-30 2011-11-03 Allergan, Inc. Remotely powered remotely adjustable gastric band system
US8517915B2 (en) 2010-06-10 2013-08-27 Allergan, Inc. Remotely adjustable gastric banding system
KR101400907B1 (ko) 2010-07-12 2014-06-10 포항공과대학교 산학협력단 조직 증강용 충전 조성물
US8889123B2 (en) 2010-08-19 2014-11-18 Allergan, Inc. Compositions and soft tissue replacement methods
US8883139B2 (en) 2010-08-19 2014-11-11 Allergan Inc. Compositions and soft tissue replacement methods
US8697057B2 (en) 2010-08-19 2014-04-15 Allergan, Inc. Compositions and soft tissue replacement methods
US9005605B2 (en) 2010-08-19 2015-04-14 Allergan, Inc. Compositions and soft tissue replacement methods
US20120059216A1 (en) 2010-09-07 2012-03-08 Allergan, Inc. Remotely adjustable gastric banding system
US8961393B2 (en) 2010-11-15 2015-02-24 Apollo Endosurgery, Inc. Gastric band devices and drive systems
CZ303548B6 (cs) 2011-01-05 2012-11-28 Contipro Pharma A.S. Zdravotní prípravek tvorící jód, zpusob jeho prípravy a bandáž, která jej obsahuje
WO2012140650A2 (en) 2011-04-12 2012-10-18 Hepacore Ltd. Conjugates of carboxy polysaccharides with fibroblast growth factors and variants thereof
US9381269B2 (en) 2011-04-13 2016-07-05 Avent, Inc. Biosorbable wound treatment device, process for making, and method of using the same
CA2833739A1 (en) 2011-04-20 2012-10-26 Carbylan Biosurgery, Inc. In-situ gel forming compositions
ITTO20110428A1 (it) 2011-05-13 2012-11-14 Rottapharm Spa Esteri dell'acido ialuronico, loro preparazione ed uso in dermatologia
CN107412002A (zh) 2011-06-03 2017-12-01 阿勒根公司 包括抗氧化剂的皮肤填充剂组合物
US9408797B2 (en) 2011-06-03 2016-08-09 Allergan, Inc. Dermal filler compositions for fine line treatment
US20130096081A1 (en) 2011-06-03 2013-04-18 Allergan, Inc. Dermal filler compositions
US9393263B2 (en) 2011-06-03 2016-07-19 Allergan, Inc. Dermal filler compositions including antioxidants
CN103687622A (zh) 2011-06-16 2014-03-26 香港科技大学 含有多个乙烯砜的分子
WO2013010045A1 (en) 2011-07-12 2013-01-17 Biotime Inc. Novel methods and formulations for orthopedic cell therapy
ES2899992T3 (es) 2011-08-10 2022-03-15 Glycores 2000 Srl Acido hialurónico reticulado de bajo peso molecular resistente a la degradación
US9662422B2 (en) 2011-09-06 2017-05-30 Allergan, Inc. Crosslinked hyaluronic acid-collagen gels for improving tissue graft viability and soft tissue augmentation
US20130244943A1 (en) 2011-09-06 2013-09-19 Allergan, Inc. Hyaluronic acid-collagen matrices for dermal filling and volumizing applications
US20140256695A1 (en) * 2011-11-11 2014-09-11 Phi Nguyen Injectable filler
FR2983483B1 (fr) 2011-12-02 2014-11-14 Vivacy Lab Procede de substitution et reticulation simultanees d'un polysaccharide via ses fonctions hydroxyles
US8876694B2 (en) 2011-12-07 2014-11-04 Apollo Endosurgery, Inc. Tube connector with a guiding tip
JP6316537B2 (ja) * 2011-12-20 2018-04-25 三洋化成工業株式会社 分岐ヒアルロン酸及びその製造方法
US8961394B2 (en) 2011-12-20 2015-02-24 Apollo Endosurgery, Inc. Self-sealing fluid joint for use with a gastric band
WO2013109959A1 (en) * 2012-01-18 2013-07-25 University Of Kansas Hyaluronic acid particles and their use in biomedical applications
DK2831237T3 (en) 2012-03-30 2018-03-05 Univ Oklahoma HIGH-MOLECULAR HEPAROSAN POLYMERS AND METHODS OF PRODUCING AND USING THEREOF
CZ2012282A3 (cs) 2012-04-25 2013-11-06 Contipro Biotech S.R.O. Zesítovaný derivát hyaluronanu, zpusob jeho prípravy, hydrogel a mikrovlákna na jeho bázi
ITPD20120173A1 (it) 2012-05-31 2013-12-01 Fidia Farmaceutici "nuovo sistema di rilascio di proteine idrofobiche"
WO2014055493A1 (en) 2012-10-02 2014-04-10 Cerulean Pharma Inc. Methods and systems for polymer precipitation and generation of particles
US20160228603A1 (en) * 2013-04-12 2016-08-11 Miba Medical Inc. Body augmentation device
CA2916119A1 (en) * 2013-06-28 2014-12-31 Galderma S.A. Method for manufacturing a shaped cross-linked hyaluronic acid product
CN103333349A (zh) * 2013-06-28 2013-10-02 陕西巨子生物技术有限公司 一种注射用透明质酸-胶原蛋白复合水凝胶及其制备方法
EP2832378A2 (en) 2013-08-01 2015-02-04 Ivis Technologies S R L Adhesive biopolymer for use as a temporary replacement of the epithelium
TWI482634B (zh) 2013-10-24 2015-05-01 Ind Tech Res Inst 生醫組合物
KR101459070B1 (ko) 2013-12-09 2014-11-17 (주) 뉴메딕 지속성을 갖는 히알루론산 겔 조성물
AR099900A1 (es) 2014-04-01 2016-08-24 Merz Pharma Gmbh & Co Kgaa Rellenos para tejidos blandos con polisacáridos con persistencia mejorada, kit, procedimiento, uso
EP4574179A3 (en) 2014-08-15 2025-10-01 The Johns Hopkins University Composite material for tissue restoration
US10722444B2 (en) 2014-09-30 2020-07-28 Allergan Industrie, Sas Stable hydrogel compositions including additives
KR101694121B1 (ko) 2014-10-28 2017-01-10 (주)헵틸와이 이중 가교구조의 생체친화형 다공성 시트 및 그 제조방법
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
KR101521058B1 (ko) 2014-12-08 2015-05-15 이노팜 주식회사 생체적합성 조성물 및 이의 제조방법
CN104530460A (zh) * 2014-12-19 2015-04-22 大连理工大学 糖基化高分子材料及其制备方法
WO2016128783A1 (en) 2015-02-09 2016-08-18 Allergan Industrie Sas Compositions and methods for improving skin appearance
US20180236129A1 (en) 2015-02-13 2018-08-23 Allergan Industrie, Sas Implants for sculpting, augmenting or correcting facial features such as the chin
CN107921237A (zh) 2015-04-27 2018-04-17 反射医学公司 交感神经心肺神经调节系统和方法
ES2872551T3 (es) * 2015-06-30 2021-11-02 Merz Pharma Gmbh & Co Kgaa Método para la producción de ácido hialurónico reticulado
KR101818705B1 (ko) 2015-07-20 2018-01-16 포항공과대학교 산학협력단 약물이 충전된 히알루론산 가교물 하이드로겔 및 이의 이용
KR20170025778A (ko) 2015-08-31 2017-03-08 대화제약 주식회사 항산화제를 포함하는 생체 적합성 고분자 히알루론산 유도체 및 그 히알루론산의 가교결합물
EP3673927A1 (en) * 2015-11-18 2020-07-01 LifeCell Corporation Hydrogel coated mesh
WO2017139487A1 (en) 2016-02-09 2017-08-17 Northwind Medical, Inc. Methods, agents, and devices for local neuromodulation of autonomic nerves
KR101866310B1 (ko) 2016-05-31 2018-06-11 주식회사 글랜젠 생체 내 지속성 및 항산화 작용이 향상된 진피 충전재 조성물 및 이의 제조방법
EP3478287A4 (en) 2016-06-29 2020-04-08 Tulavi Therapeutics, Inc. TREATMENT OF SEPTICEMIA AND ASSOCIATED INFLAMMATORY CONDITIONS BY LOCAL NEUROMODULATION OF THE AUTONOMOUS NERVOUS SYSTEM
WO2018053276A1 (en) 2016-09-16 2018-03-22 Glycologix, Llc Sulfated glycosaminoglycan biomaterials as proteoglycan mimics
CZ2016826A3 (cs) 2016-12-22 2018-07-04 Contipro A.S. Léčivý prostředek s nosičem na bázi hyaluronanu a/nebo jeho derivátů, způsob výroby a použití
CA3052135C (en) 2017-02-02 2022-01-11 Amtixbio Co., Ltd. Hydrogel using, as substrate, hyaluronic acid derivative modified with gallol group and use thereof
US20190240335A1 (en) 2018-02-07 2019-08-08 Promedon S.A. Biocompatible Hydrogel Compositions
CA3134480A1 (en) * 2018-03-29 2020-10-03 Ramesh S. AYYALA Methods and compositions for delivery of a therapeutic agent
WO2019217765A1 (en) 2018-05-09 2019-11-14 The Johns Hopkins University Nanofiber-hydrogel composites for cell and tissue delivery
CN112423799A (zh) 2018-05-09 2021-02-26 约翰·霍普金斯大学 用于增强的软组织替代和再生的纳米纤维-水凝胶复合物
IL279445B2 (en) 2018-06-15 2025-05-01 Croma Pharma Gmbh Stabilized hyaluronic acid
US12297346B2 (en) 2018-06-15 2025-05-13 Croma-Pharma Gmbh Hydrogel composition comprising a crosslinked polymer
US20210315587A1 (en) 2018-07-02 2021-10-14 Tulavi Therapeutics, Inc. Methods and devices for in situ formed nerve cap with rapid release
CN112638437B (zh) 2018-07-02 2023-12-08 图拉维治疗股份有限公司 原位形成神经帽的方法和装置
KR102392812B1 (ko) 2018-07-06 2022-04-29 주식회사 엘지화학 높은 점탄성 및 응집성을 동시에 갖는 히알루론산 필러
HUE065503T2 (hu) 2018-07-10 2024-05-28 Lg Chemical Ltd Nagy emelõkapacitású és alacsony injekciós erejû hialuronsav-töltõanyag
KR102334794B1 (ko) 2018-12-20 2021-12-03 주식회사 엘지화학 우수한 필러 특성을 갖는 히알루론산 하이드로겔을 포함하는 필러
EP3900750A4 (en) 2018-12-21 2022-02-16 LG Chem, Ltd. FILLER WITH HYALURONIC ACID HYDROGEL WITH EXCELLENT FILLING PROPERTIES
KR102162724B1 (ko) 2020-03-24 2020-10-07 바이오플러스 주식회사 가교 히알루론산 겔 및 이의 제조 방법
WO2021201150A1 (ja) 2020-03-31 2021-10-07 株式会社クレハ 生体吸収性医療材料
CA3177686A1 (en) * 2020-05-14 2021-11-18 Allergan Pharmaceuticals International Limited Compositions comprising tropoelastin crosslinked to hyaluronic acid and methods of use thereof
KR102366394B1 (ko) * 2021-01-05 2022-02-23 조광용 고팽윤성 히알루론산 비드 겔
KR20220106283A (ko) 2021-01-22 2022-07-29 (주)앰틱스바이오 자가 가교형 히알루론산 유도체 기반 창상피복재
KR102598899B1 (ko) * 2021-05-13 2023-11-07 주식회사 바이오스탠다드 히알루론산 기반 기능성 하이드로겔 복합체 및 이의 제조방법
WO2023010115A1 (en) * 2021-07-30 2023-02-02 Regents Of The University Of Minnesota Biomaterials for embolization and drug delivery
US11980699B2 (en) 2021-09-01 2024-05-14 Shanghai Qisheng Biological Preparation Co., Ltd. Cartilage regeneration using injectable, in situ polymerizable collagen compositions containing chondrocytes or stem cells
US20240269349A1 (en) 2021-09-09 2024-08-15 Sunbio Inc. Sol-gel conversion over time of 6-arm peg hydrogel
CN118434792A (zh) 2021-12-28 2024-08-02 上海其胜生物制剂有限公司 透明质酸-胶原共聚物组合物及其医学应用
WO2024172910A1 (en) * 2023-02-15 2024-08-22 Lifesprout, Inc. Modified crosslinked polymers
WO2025091137A1 (en) 2023-11-02 2025-05-08 Volumina Medical Sa Implantable device compositions including ester bonds

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1047380B (de) * 1954-08-18 1958-12-24 American Home Prod Verfahren zur Herstellung einer hyaluronidasefreien, teilweise depolymerisierte Hyaluronsaeure enthaltenden waessrigen Traegerloesung fuer Arzneimittel
DE1043589B (de) * 1956-01-02 1958-11-13 Kisaku Ibe Haut- und Haarpflegemittel und Verfahren zu ihrer Herstellung
US3357784A (en) * 1964-09-30 1967-12-12 Kendall & Co Exposure to intense ultraviolet light to improve characteristics of cellulosic fabrics in divinyl sulfone and glyoxal cross-linking processes
SE361320B (enExample) * 1972-03-14 1973-10-29 Exploaterings Ab Tbf
US4152170A (en) 1975-06-18 1979-05-01 Sumitomo Chemical Company, Ltd. Cross-linked pullulan
GB1515963A (en) * 1975-07-15 1978-06-28 Massachusetts Inst Technology Crosslinked collagen-mucopolysaccharide composite materials
US4141973A (en) * 1975-10-17 1979-02-27 Biotrics, Inc. Ultrapure hyaluronic acid and the use thereof
US4303676A (en) * 1980-03-21 1981-12-01 Balazs Endre A Hyaluronate based compositions and cosmetic formulations containing same
JPS59162779A (ja) * 1983-03-04 1984-09-13 Toshiba Corp 周波数変換装置の制御方法
US4448718A (en) * 1983-09-13 1984-05-15 Massachusetts Institute Of Technology Method for the preparation of collagen-glycosaminoglycan composite materials
CA1238043A (en) * 1983-12-15 1988-06-14 Endre A. Balazs Water insoluble preparations of hyaluronic acid and processes therefor
US4487865A (en) * 1983-12-15 1984-12-11 Biomatrix, Inc. Polymeric articles modified with hyaluronate
US4500676A (en) * 1983-12-15 1985-02-19 Biomatrix, Inc. Hyaluronate modified polymeric articles
US4713448A (en) * 1985-03-12 1987-12-15 Biomatrix, Inc. Chemically modified hyaluronic acid preparation and method of recovery thereof from animal tissues

Also Published As

Publication number Publication date
JPH0430961B2 (enExample) 1992-05-25
GB2181148B (en) 1989-06-07
GB2168067A (en) 1986-06-11
SE8901672D0 (sv) 1989-05-10
AU569157B2 (en) 1988-01-21
IT1187737B (it) 1987-12-23
GB2181147A (en) 1987-04-15
DE3546811C2 (enExample) 1993-09-02
SE8901672L (sv) 1989-05-10
AU572419B2 (en) 1988-05-05
GB2168067B (en) 1989-06-07
SE501828C2 (sv) 1995-05-22
FR2574414A1 (fr) 1986-06-13
JPH02138346A (ja) 1990-05-28
AU7217387A (en) 1987-08-27
GB2181148A (en) 1987-04-15
JPH0637575B2 (ja) 1994-05-18
IT8522089A0 (it) 1985-09-09
FR2574414B1 (fr) 1987-07-03
AU4304585A (en) 1986-06-12
SE8503486D0 (sv) 1985-07-15
GB8618719D0 (en) 1986-09-10
SE460792B (sv) 1989-11-20
GB8618720D0 (en) 1986-09-10
SE8503486L (sv) 1986-06-07
DE3520008A1 (de) 1986-06-19
DE3520008C2 (enExample) 1991-10-10
JPS61138601A (ja) 1986-06-26
GB8512072D0 (en) 1985-06-19
US4582865A (en) 1986-04-15
GB2205848A (en) 1988-12-21
GB2205848B (en) 1989-05-24
GB2181147B (en) 1989-06-07
GB8817772D0 (en) 1988-09-01

Similar Documents

Publication Publication Date Title
CA1230186A (en) Cross-linked gels of hyaluronic acid and products containing such gels
US4605691A (en) Cross-linked gels of hyaluronic acid and products containing such gels
US4636524A (en) Cross-linked gels of hyaluronic acid and products containing such gels
CA1276143C (en) Chemically modified hyaluronic acid preparation and method of recovery thereof from animal tissues
EP0224987B1 (en) Drug delivery systems based on hyaluronan, derivatives thereof and their salts and method of producing same
Muzzarelli Carboxymethylated chitins and chitosans
Holme et al. Chitosan N-sulfate. A water-soluble polyelectrolyte
Rinaudo Main properties and current applications of some polysaccharides as biomaterials
AU773628B2 (en) Process for cross-linking hyaluronic acid to polymers
US5099013A (en) Hylan preparation and method of recovery thereof from animal tissues
JP2684208B2 (ja) 水不溶性バイオ適合性ゲルの製造方法
EP1753787B1 (en) Method of covalently linking hyaluronan and chitosan
US5827937A (en) Polysaccharide gel composition
US7521434B2 (en) Cross-linked gels of hyaluronic acid with hydrophobic polymers and processes for making them
JP7784138B2 (ja) 超分岐ポリグリセロールポリグリシジルエーテルおよび多糖用の架橋物質としてのその使用
JP2010077434A (ja) 架橋ヒアルロン酸の製造方法
EP0939086B1 (en) Process for producing crosslinked hyaluronic acid
Burchard Networks in nature
EP2844310B1 (en) Shape-memory cross-linked polysaccharides
CN120025572B (zh) 一种具有抗酶解性能的葡聚糖-透明质酸钠凝胶的制备方法
Schuerch Biomedical applications of polysaccharides
RU2788454C1 (ru) Способ получения гибридного препарата бромелайна и карбоксиметилцеллюлозы в виде густого раствора

Legal Events

Date Code Title Description
MKEX Expiry