BR0115978A - Cadeia leve, cadeia pesada, imunoglobulina ou fragmento de ligação de antìgeno, anticorpo humanizado ou fragmento de ligação de antìgeno do mesmo, métodos para prevenir ou tratar uma doença amiloidogênica e doença de alzheimer em um paciente, composição farmacêutica, polipeptìdeo isolado, variante de um polipeptìdeo, mólecula de ácido nucleico isolada, vetor, célula hospedeira, método para produzir um anticorpo, ou fragmento do mesmo, método para identificar resìduos que levem à substituição em uma região de esqueleto variável de imunoglobina 3d6 humanizada, uso de seguência de região variável especificada, e, molécula de ácido nucleico isolada - Google Patents

Cadeia leve, cadeia pesada, imunoglobulina ou fragmento de ligação de antìgeno, anticorpo humanizado ou fragmento de ligação de antìgeno do mesmo, métodos para prevenir ou tratar uma doença amiloidogênica e doença de alzheimer em um paciente, composição farmacêutica, polipeptìdeo isolado, variante de um polipeptìdeo, mólecula de ácido nucleico isolada, vetor, célula hospedeira, método para produzir um anticorpo, ou fragmento do mesmo, método para identificar resìduos que levem à substituição em uma região de esqueleto variável de imunoglobina 3d6 humanizada, uso de seguência de região variável especificada, e, molécula de ácido nucleico isolada

Info

Publication number
BR0115978A
BR0115978A BR0115978-0A BR0115978A BR0115978A BR 0115978 A BR0115978 A BR 0115978A BR 0115978 A BR0115978 A BR 0115978A BR 0115978 A BR0115978 A BR 0115978A
Authority
BR
Brazil
Prior art keywords
nucleic acid
acid molecule
antigen binding
humanized
binding fragment
Prior art date
Application number
BR0115978-0A
Other languages
English (en)
Inventor
Guriq Basi
Jose Saldanha
Ted Yednock
Original Assignee
Neuralab Ltd
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22953834&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0115978(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Neuralab Ltd, Wyeth Corp filed Critical Neuralab Ltd
Publication of BR0115978A publication Critical patent/BR0115978A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/193—Colony stimulating factors [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0007—Nervous system antigens; Prions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurosurgery (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Mycology (AREA)
  • Psychology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Peptides Or Proteins (AREA)

Abstract

"CADEIA LEVE, CADEIA PESADA, IMUNOGLOBULINA OUFRAGMENTO DE LIGAçãO DE ANTìGENO, ANTICORPO HUMANIZADO OU FRAGMENTO DE LIGAçãO DE ANTìGENO DO MESMO, MéTODOS PARA PREVENIR OU TRATAR UMA DOENçA AMILOIDOGêNICA E DOENçA DE ALZHEIMER EM UM PACIENTE, COMPOSIçãO FARMACêUTICA, POLIPEPTìDEO ISOLADO, VARIANTE DE UM POLIPEPTìDEO, MOLéCULA DE áCIDO NUCLEICO ISOLADA, VETOR, CéLULA HOSPEDEIRA, MéTODO PARA PRODUZIR UM ANTICORPO, OU FRAGMENTO DO MESMO, MéTODO PARA IDENTIFICAR RESìDUOS QUE LEVEM á SUBSTITUIçãO EM UMA REGIãO DE ESQUELETO VARIáVEL DE IMUNOGLOBULINA 3D6 HUMANIZADA, USO DE SEQuêNCIA DE REGIãO VARIáVEL ESPECIFICADA, E, MOLéCULA DE áCIDO NUCLEICO ISOLADA". A invenção provê melhorados agentes e métodos para o tratamento de doenças associadas com depósitos amilóides de A<225> no cérebro de um paciente. Os agentes preferidos incluem anticorpos humanizados.
BR0115978-0A 2000-12-06 2001-12-06 Cadeia leve, cadeia pesada, imunoglobulina ou fragmento de ligação de antìgeno, anticorpo humanizado ou fragmento de ligação de antìgeno do mesmo, métodos para prevenir ou tratar uma doença amiloidogênica e doença de alzheimer em um paciente, composição farmacêutica, polipeptìdeo isolado, variante de um polipeptìdeo, mólecula de ácido nucleico isolada, vetor, célula hospedeira, método para produzir um anticorpo, ou fragmento do mesmo, método para identificar resìduos que levem à substituição em uma região de esqueleto variável de imunoglobina 3d6 humanizada, uso de seguência de região variável especificada, e, molécula de ácido nucleico isolada BR0115978A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25189200P 2000-12-06 2000-12-06
PCT/US2001/046587 WO2002046237A2 (en) 2000-12-06 2001-12-06 Humanized antibodies that recognize beta amyloid peptide

Publications (1)

Publication Number Publication Date
BR0115978A true BR0115978A (pt) 2005-05-03

Family

ID=22953834

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0115978-0A BR0115978A (pt) 2000-12-06 2001-12-06 Cadeia leve, cadeia pesada, imunoglobulina ou fragmento de ligação de antìgeno, anticorpo humanizado ou fragmento de ligação de antìgeno do mesmo, métodos para prevenir ou tratar uma doença amiloidogênica e doença de alzheimer em um paciente, composição farmacêutica, polipeptìdeo isolado, variante de um polipeptìdeo, mólecula de ácido nucleico isolada, vetor, célula hospedeira, método para produzir um anticorpo, ou fragmento do mesmo, método para identificar resìduos que levem à substituição em uma região de esqueleto variável de imunoglobina 3d6 humanizada, uso de seguência de região variável especificada, e, molécula de ácido nucleico isolada

Country Status (39)

Country Link
US (2) US7189819B2 (pt)
EP (2) EP1358213B1 (pt)
JP (6) JP4166569B2 (pt)
KR (2) KR100996936B1 (pt)
CN (4) CN100448893C (pt)
AR (1) AR035402A1 (pt)
AT (1) ATE414719T1 (pt)
AU (2) AU2592102A (pt)
BG (1) BG66292B1 (pt)
BR (1) BR0115978A (pt)
CA (1) CA2430772C (pt)
CY (1) CY1108740T1 (pt)
CZ (1) CZ20031601A3 (pt)
DE (1) DE60136651D1 (pt)
DK (1) DK1358213T3 (pt)
EA (2) EA011450B1 (pt)
EC (1) ECSP034685A (pt)
EE (1) EE05309B1 (pt)
ES (1) ES2317953T3 (pt)
GE (1) GEP20084339B (pt)
HK (1) HK1070904A1 (pt)
HR (1) HRP20030547A8 (pt)
HU (1) HU229681B1 (pt)
IL (2) IL156030A0 (pt)
IS (1) IS2620B (pt)
MX (1) MXPA03005048A (pt)
MY (2) MY162171A (pt)
NO (1) NO339290B1 (pt)
NZ (3) NZ526813A (pt)
PE (1) PE20020574A1 (pt)
PL (1) PL211761B1 (pt)
PT (1) PT1358213E (pt)
SI (1) SI1358213T1 (pt)
SK (1) SK288209B6 (pt)
TW (1) TWI255272B (pt)
UA (1) UA87093C2 (pt)
UY (1) UY27062A1 (pt)
WO (1) WO2002046237A2 (pt)
ZA (1) ZA200305169B (pt)

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