CY1110033T1 - Τεχνητα ανθρωπινα θεραπευτικα αντισωματα εναντια σε ισομορφες cd45 - Google Patents

Τεχνητα ανθρωπινα θεραπευτικα αντισωματα εναντια σε ισομορφες cd45

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Publication number
CY1110033T1
CY1110033T1 CY20101100424T CY101100424T CY1110033T1 CY 1110033 T1 CY1110033 T1 CY 1110033T1 CY 20101100424 T CY20101100424 T CY 20101100424T CY 101100424 T CY101100424 T CY 101100424T CY 1110033 T1 CY1110033 T1 CY 1110033T1
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CY
Cyprus
Prior art keywords
ser
asn
ile
thr
tyr
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Application number
CY20101100424T
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English (en)
Inventor
Frank Kolbinger
Herrera José M Carballido
András ASZODI
José W SALDANHA
Bruce M Hall
Silvia Gregori
Maria Grazia Roncarolo
Véronique Loux
Gregorio Aversa
Margit Jeschke
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Priority claimed from US10/666,332 external-priority patent/US20050069538A1/en
Priority claimed from GB0414309A external-priority patent/GB0414309D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CY1110033T1 publication Critical patent/CY1110033T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/289—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD45
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Ένα μόριο το οποίο περιλαμβάνει τουλάχιστον ένα σημείο πρόσδεσης αντιγόνου, το οποίο περιλαμβάνει σε ακολουθία τις υπερ-κυμαινόμενες περιοχές CDR1, CDR2 και CDR3, όπου η CDR1 διαθέτει την ακολουθία αμινοξέος Asn-Tyr-Ile-Ile-His (ΝΥIIΗ), η CDR2 διαθέτει την ακολουθία αμινοξέος Tyr-Phe-Asn-Pro-Tyr-Asn-His-Gly-Thr-Lys-Tyr-Asn-Glu-Lys-Phe-Lys-Gly (YFNPYNHGTKYNEKFKG) και η CDR3 διαθέτει την ακολουθία αμινοξέος Ser-Gly-Pro-Tyr-Ala-Trp-Phe-Asp-Thr (SGPYAWFDT) · για παράδειγμα, περιλαμβάνει περαιτέρω σε ακολουθία τις υπερ-κυμαινόμενες περιοχές CDR1', CDR2' και CDR3', όπου η CDR1' διαθέτει την ακολουθία αμινοξέος Arg-Ala-Ser-Gln-Asn-Ile-Gly-Thr-Ser-Ile-Gln (RASQNIGTSIQ), η CDR2' διαθέτει την ακολουθία αμινοξέος Ser-Ser-Ser-Glu-Ser-Ile-Ser (SSSESIS) και η CDR3' διαθέτει την ακολουθία αμινοξέος Gln-Gln-Ser-Asn-Thr-Trp-Pro-Phe-Thr (QQSNTWPFT), π.χ. ένα χιμαιρικό ή τεχνητό ανθρώπινο αντίσωμα, χρήσιμο ως φαρμακευτικό προϊόν.
CY20101100424T 2003-09-18 2010-05-14 Τεχνητα ανθρωπινα θεραπευτικα αντισωματα εναντια σε ισομορφες cd45 CY1110033T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/666,332 US20050069538A1 (en) 2003-09-18 2003-09-18 Therapeutic binding molecules
GB0414309A GB0414309D0 (en) 2004-06-25 2004-06-25 Organic compounds
EP04765363A EP1664122B1 (en) 2003-09-18 2004-09-17 Therapeutic humanised antibodies against cd45 isoforms

Publications (1)

Publication Number Publication Date
CY1110033T1 true CY1110033T1 (el) 2015-01-14

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ID=34315457

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CY20101100424T CY1110033T1 (el) 2003-09-18 2010-05-14 Τεχνητα ανθρωπινα θεραπευτικα αντισωματα εναντια σε ισομορφες cd45

Country Status (29)

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EP (1) EP1664122B1 (el)
JP (1) JP4762142B2 (el)
KR (1) KR20060079232A (el)
AR (2) AR045765A1 (el)
AT (1) ATE461219T1 (el)
AU (1) AU2004272289B2 (el)
BR (1) BRPI0414515A (el)
CA (1) CA2537217A1 (el)
CY (1) CY1110033T1 (el)
DE (1) DE602004026081D1 (el)
DK (1) DK1664122T3 (el)
EC (1) ECSP066432A (el)
ES (1) ES2341341T3 (el)
HK (1) HK1091844A1 (el)
HR (1) HRP20100334T1 (el)
IL (1) IL173820A0 (el)
IS (1) IS8397A (el)
MA (1) MA28041A1 (el)
MY (1) MY143963A (el)
NO (1) NO20061681L (el)
NZ (1) NZ545605A (el)
PE (1) PE20060019A1 (el)
PL (1) PL1664122T3 (el)
PT (1) PT1664122E (el)
RU (1) RU2386639C2 (el)
SI (1) SI1664122T1 (el)
TN (1) TNSN06087A1 (el)
TW (1) TW200521231A (el)
WO (1) WO2005026210A2 (el)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2502631A1 (en) 2011-03-22 2012-09-26 Medizinische Hochschule Hannover Immune suppressor and its use
GB201409558D0 (en) 2014-05-29 2014-07-16 Ucb Biopharma Sprl Method
GB201412659D0 (en) 2014-07-16 2014-08-27 Ucb Biopharma Sprl Molecules
GB201412658D0 (en) 2014-07-16 2014-08-27 Ucb Biopharma Sprl Molecules
CN105886609B (zh) * 2015-02-17 2020-02-21 陈沛隆 药物不良反应风险评估方法及其装置
BR112017021536A2 (pt) 2015-04-06 2018-07-03 Harvard College composições e métodos para o condicionamento não mieloablativo
GB201601075D0 (en) 2016-01-20 2016-03-02 Ucb Biopharma Sprl Antibodies molecules
GB201601077D0 (en) 2016-01-20 2016-03-02 Ucb Biopharma Sprl Antibody molecule
GB201601073D0 (en) * 2016-01-20 2016-03-02 Ucb Biopharma Sprl Antibodies
GB201521383D0 (en) 2015-12-03 2016-01-20 Ucb Biopharma Sprl And Ucb Celltech Method
GB201521389D0 (en) 2015-12-03 2016-01-20 Ucb Biopharma Sprl Method
GB201521382D0 (en) 2015-12-03 2016-01-20 Ucb Biopharma Sprl Antibodies
GB201521393D0 (en) 2015-12-03 2016-01-20 Ucb Biopharma Sprl Antibodies
GB201521391D0 (en) 2015-12-03 2016-01-20 Ucb Biopharma Sprl Antibodies
BR112018076263A2 (pt) * 2016-06-17 2019-03-26 Magenta Therapeutics, Inc. composições e métodos para a depleção de células
US20210246227A1 (en) 2017-05-31 2021-08-12 Elstar Therapeutics, Inc. Multispecific molecules that bind to myeloproliferative leukemia (mpl) protein and uses thereof
JP2023547795A (ja) 2020-10-15 2023-11-14 ユーシービー バイオファルマ エスアールエル Ｃｄ４５を多量体化する結合分子
JP2024500189A (ja) 2020-12-21 2024-01-04 アロジーン セラピューティクス，インコーポレイテッド プロテアーゼ活性化ｃｄ４５ゲートｃａｒ
WO2023091954A2 (en) 2021-11-19 2023-05-25 The Trustees Of The University Of Pennsylvania Engineered pan-leukocyte antigen cd45 to facilitate car t cell therapy

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6106834A (en) * 1993-06-02 2000-08-22 Research Corporation Technologies, Inc. Use of anti-CD45 leukocyte antigen antibodies for immunomodulation
GB0103389D0 (en) * 2001-02-12 2001-03-28 Novartis Ag Organic compounds

Also Published As

Publication number Publication date
AR045765A1 (es) 2005-11-09
JP2007529196A (ja) 2007-10-25
PE20060019A1 (es) 2006-02-27
TW200521231A (en) 2005-07-01
IL173820A0 (en) 2006-07-05
HK1091844A1 (en) 2007-01-26
AU2004272289A1 (en) 2005-03-24
AR079458A2 (es) 2012-01-25
KR20060079232A (ko) 2006-07-05
NO20061681L (no) 2006-06-13
DE602004026081D1 (de) 2010-04-29
WO2005026210A3 (en) 2005-07-14
WO2005026210A2 (en) 2005-03-24
IS8397A (is) 2006-04-03
NZ545605A (en) 2009-03-31
MY143963A (en) 2011-07-29
PT1664122E (pt) 2010-05-10
EP1664122A2 (en) 2006-06-07
ATE461219T1 (de) 2010-04-15
CA2537217A1 (en) 2005-03-24
BRPI0414515A (pt) 2006-11-07
ES2341341T3 (es) 2010-06-18
RU2006112598A (ru) 2007-10-27
MA28041A1 (fr) 2006-07-03
SI1664122T1 (sl) 2010-07-30
PL1664122T3 (pl) 2010-08-31
EP1664122B1 (en) 2010-03-17
HRP20100334T1 (hr) 2010-07-31
TNSN06087A1 (en) 2007-10-03
DK1664122T3 (da) 2010-06-28
AU2004272289B2 (en) 2008-09-18
JP4762142B2 (ja) 2011-08-31
ECSP066432A (es) 2006-09-18
RU2386639C2 (ru) 2010-04-20

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