RU2386639C2 - Связывающие молекулы, обладающие терапевтической активностью - Google Patents

Связывающие молекулы, обладающие терапевтической активностью Download PDF

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RU2386639C2
RU2386639C2 RU2006112598/13A RU2006112598A RU2386639C2 RU 2386639 C2 RU2386639 C2 RU 2386639C2 RU 2006112598/13 A RU2006112598/13 A RU 2006112598/13A RU 2006112598 A RU2006112598 A RU 2006112598A RU 2386639 C2 RU2386639 C2 RU 2386639C2
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polypeptide
sequence
antibody
cd45ro
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Франк КОЛЬБИНГЕР (DE)
Франк Кольбингер
Хосе М. КАРБАЛЛИДО-ЭРЕРРА (AT)
Хосе М. КАРБАЛЛИДО-ЭРЕРРА
Андраш АСОДИ (AT)
Андраш АСОДИ
Хосе У. САЛДАНА (GB)
Хосе У. САЛДАНА
Брюс М. ХОЛЛ (AU)
Брюс М. ХОЛЛ
Сильвия ГРЕГОРИ (IT)
Сильвия ГРЕГОРИ
Мария Грация РОНКАРОЛО (IT)
Мария Грация РОНКАРОЛО
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Вероник ЛУ
Грегорио АВЕРСА (CA)
Грегорио АВЕРСА
Маргит ЙЕШКЕ (CH)
Маргит ЙЕШКЕ
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Abstract

Изобретение относится к области иммунологии и биотехнологии. Описаны варианты гуманизированного антитела к CD45RO/RB, несущие легкую и тяжелую цепь. Раскрыты варианты: выделенного полинуклеотида, кодирующего антитела, экспрессионного вектора, содержащего полинуклеотид и клетки-хозяина, включающей вектор экспрессии. Описано применение антитела для лечения и/или профилактики различных заболеваний, в том числе в составе фармацевтической композиции. Использование изобретения обеспечивает антитела, распознающие как CD45RO, так и CD45RB, что может найти применение в медицине. 7 н. и 2 з.п. ф-лы, 14 ил., 2 табл.

Description

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Claims (9)

1. Гуманизированное антитело к CD45RO/RB, содержащее полипептид, имеющий последовательность SEQ ID NO:31 или SEQ ID NO:32, и полипептид, имеющий последовательность SEQ ID NO:7 или SEQ ID NO:8.
2. Гуманизированное антитело к CD45RO/RB, которое содержит
полипептид, имеющий последовательность SEQ ID NO:31, и полипептид, имеющий последовательность SEQ ID NO:7,
полипептид, имеющий последовательность SEQ ID NO:31, и полипептид, имеющий последовательность SEQ ID NO:8,
полипептид, имеющий последовательность SEQ ID NO:32, и полипептид, имеющий последовательность SEQ ID NO:7, или
полипептид, имеющий последовательность SEQ ID NO:32, и полипептид, имеющий последовательность SEQ ID NO:8.
3. Выделенный полинуклеотид, кодирующий антитело по одному из пп.1 и 2.
4. Экспрессионный вектор, содержащий полинуклеотиды по п.3.
5. Выделенная эукариотическая клетка-хозяин, которая включает систему экспрессии по п.4.
6. Применение гуманизированного антитела по одному из пп.1 и 2 или выделенного полинуклеотида по п.3 для лечения и/или профилактики аутоиммунных заболеваний, отторжения трансплантата, псориаза, дерматита, воспалительного заболевания кишечника и/или аллергий.
7. Применение по п.6 для лечения и/или профилактики реакции трансплантат против хозяина (РТПХ).
8. Применение гуманизированного антитела по п.6 для приготовления лекарственного средства, предназначенного для лечения отторжения трансплантата панкреатических островковых клеток.
9. Фармацевтическая композиция для лечения и/или профилактики аутоиммунных заболеваний, отторжения трансплантата, псориаза, дерматита, воспалительного заболевания кишечника и/или аллергий, включающая терапевтически эффективное количество гуманизированнного антитела по одному из пп.1-3 в сочетании по меньшей мере с одним фармацевтически приемлемым носителем или разбавителем.
RU2006112598/13A 2003-09-18 2004-09-17 Связывающие молекулы, обладающие терапевтической активностью RU2386639C2 (ru)

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US10/666,332 2003-09-18
US10/666,332 US20050069538A1 (en) 2003-09-18 2003-09-18 Therapeutic binding molecules
GB0414309.5 2004-06-25
GB0414309A GB0414309D0 (en) 2004-06-25 2004-06-25 Organic compounds

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EP2502631A1 (en) 2011-03-22 2012-09-26 Medizinische Hochschule Hannover Immune suppressor and its use
GB201409558D0 (en) 2014-05-29 2014-07-16 Ucb Biopharma Sprl Method
GB201412659D0 (en) 2014-07-16 2014-08-27 Ucb Biopharma Sprl Molecules
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CN105886609B (zh) * 2015-02-17 2020-02-21 陈沛隆 药物不良反应风险评估方法及其装置
CA2982115A1 (en) 2015-04-06 2016-10-13 President And Fellows Of Harvard College Compositions and methods for non-myeloablative conditioning
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JP2019522050A (ja) * 2016-06-17 2019-08-08 マジェンタ セラピューティクス インコーポレイテッドＭａｇｅｎｔａ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． 細胞の枯渇のための組成物および方法
JP2020522254A (ja) 2017-05-31 2020-07-30 エルスター セラピューティクス， インコーポレイテッド 骨髄増殖性白血病（ｍｐｌ）タンパク質に結合する多特異性分子およびその使用
WO2022079199A1 (en) 2020-10-15 2022-04-21 UCB Biopharma SRL Binding molecules that multimerise cd45
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Publication number Priority date Publication date Assignee Title
US6106834A (en) * 1993-06-02 2000-08-22 Research Corporation Technologies, Inc. Use of anti-CD45 leukocyte antigen antibodies for immunomodulation
GB0103389D0 (en) * 2001-02-12 2001-03-28 Novartis Ag Organic compounds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Friend et. al., "Phase I study of an engineered aglycosylated humanized CD3 antibody in renal transplant rejection", Transplantation, vol.68 (11), стр.1632-1637, 1999. *

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