BR0318454A - anticorpos dirigidos a hormÈnio da paratireóide (pth) e seus usos - Google Patents

anticorpos dirigidos a hormÈnio da paratireóide (pth) e seus usos

Info

Publication number
BR0318454A
BR0318454A BRPI0318454-4A BR0318454A BR0318454A BR 0318454 A BR0318454 A BR 0318454A BR 0318454 A BR0318454 A BR 0318454A BR 0318454 A BR0318454 A BR 0318454A
Authority
BR
Brazil
Prior art keywords
pth
parathyroid hormone
antigen
light chain
targeting antibodies
Prior art date
Application number
BRPI0318454-4A
Other languages
English (en)
Inventor
Lorin Roskos
Ian Foltz
Chadwick T King
Original Assignee
Abgenix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abgenix Inc filed Critical Abgenix Inc
Publication of BR0318454A publication Critical patent/BR0318454A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A61P5/20—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

"ANTICORPOS DIRIGIDOS A HORMÈNIO DA PARATIREóIDE (PTH) E SEUS USOS". Concretizações da invenção aqui descritas se referem aos anticorpos dirigidos ao hormónio da paratireóide (PTH) antígeno e aos usos de tais anticorpos. Especificamente, em algumas concretizações, são fornecidos anticorpos monoclonais totalmente humanos dirigidos ao PTH antígeno. Em concretizações adicionais, são fornecidas seqüências de nucleotídeos codificando, e seqüências de aminoácidos compreendendo, moléculas de imunoglobulina de cadeia pesada e de cadeia leve, particularmente seqüências correspondendo a seqüências de cadeia pesada e de cadeia leve contígüas, abrangendo as regiões de estrutura e/ou regiões de determinação de complementaridade (CDR), especialmente a partir de FR1 a FR4 ou CDR1 a CDR3.
BRPI0318454-4A 2003-08-08 2003-08-08 anticorpos dirigidos a hormÈnio da paratireóide (pth) e seus usos BR0318454A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2003/025161 WO2005016111A2 (en) 2003-08-08 2003-08-08 Antibodies directed to parathyroid hormone (pth) and uses thereof

Publications (1)

Publication Number Publication Date
BR0318454A true BR0318454A (pt) 2006-09-12

Family

ID=34572264

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0318454-4A BR0318454A (pt) 2003-08-08 2003-08-08 anticorpos dirigidos a hormÈnio da paratireóide (pth) e seus usos

Country Status (14)

Country Link
US (1) US7288253B2 (pt)
EP (1) EP1659918B1 (pt)
JP (1) JP2007521232A (pt)
CN (1) CN1838968A (pt)
AT (1) ATE420660T1 (pt)
AU (1) AU2003282780A1 (pt)
BR (1) BR0318454A (pt)
CA (1) CA2535156A1 (pt)
DE (1) DE60325906D1 (pt)
ES (1) ES2321088T3 (pt)
IL (1) IL173323A0 (pt)
MX (1) MXPA06001353A (pt)
NO (1) NO20061070L (pt)
WO (1) WO2005016111A2 (pt)

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WO2005016111A9 (en) 2005-05-19
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CN1838968A (zh) 2006-09-27
US7288253B2 (en) 2007-10-30
EP1659918A4 (en) 2007-05-02
EP1659918B1 (en) 2009-01-14
AU2003282780A1 (en) 2005-03-07
US20050031614A1 (en) 2005-02-10
CA2535156A1 (en) 2005-02-24
NO20061070L (no) 2006-05-05
WO2005016111A2 (en) 2005-02-24
ATE420660T1 (de) 2009-01-15
JP2007521232A (ja) 2007-08-02
ES2321088T3 (es) 2009-06-02

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