ATE154644T1 - Nukleinsäureverstärkung - Google Patents

Nukleinsäureverstärkung

Info

Publication number
ATE154644T1
ATE154644T1 AT90913353T AT90913353T ATE154644T1 AT E154644 T1 ATE154644 T1 AT E154644T1 AT 90913353 T AT90913353 T AT 90913353T AT 90913353 T AT90913353 T AT 90913353T AT E154644 T1 ATE154644 T1 AT E154644T1
Authority
AT
Austria
Prior art keywords
nucleic acid
primer
sequence
specific nucleic
template
Prior art date
Application number
AT90913353T
Other languages
English (en)
Inventor
Lawrence T Malek
Cheryl Davey
Graham Henderson
Roy Sooknanan
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Application granted granted Critical
Publication of ATE154644T1 publication Critical patent/ATE154644T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6832—Enhancement of hybridisation reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6865—Promoter-based amplification, e.g. nucleic acid sequence amplification [NASBA], self-sustained sequence replication [3SR] or transcription-based amplification system [TAS]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Networks Using Active Elements (AREA)
AT90913353T 1989-08-23 1990-08-23 Nukleinsäureverstärkung ATE154644T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/397,681 US5130238A (en) 1988-06-24 1989-08-23 Enhanced nucleic acid amplification process

Publications (1)

Publication Number Publication Date
ATE154644T1 true ATE154644T1 (de) 1997-07-15

Family

ID=23572204

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90913353T ATE154644T1 (de) 1989-08-23 1990-08-23 Nukleinsäureverstärkung

Country Status (13)

Country Link
US (1) US5130238A (de)
EP (1) EP0487628B1 (de)
JP (1) JP2648802B2 (de)
KR (1) KR960005737B1 (de)
AT (1) ATE154644T1 (de)
AU (1) AU647411B2 (de)
CA (1) CA2065003C (de)
DE (1) DE69030955T2 (de)
DK (1) DK0487628T3 (de)
ES (1) ES2104611T3 (de)
FI (1) FI100192B (de)
NZ (1) NZ235009A (de)
WO (1) WO1991002818A1 (de)

Families Citing this family (946)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6090591A (en) * 1987-07-31 2000-07-18 The Board Of Trustees Of The Leland Stanford Junior University Selective amplification of target polynucleotide sequences
WO1989001050A1 (en) * 1987-07-31 1989-02-09 The Board Of Trustees Of The Leland Stanford Junior University Selective amplification of target polynucleotide sequences
US5622820A (en) * 1988-03-10 1997-04-22 City Of Hope Method for amplification and detection of RNA and DNA sequences
CA2020958C (en) * 1989-07-11 2005-01-11 Daniel L. Kacian Nucleic acid sequence amplification methods
US7009041B1 (en) 1989-07-11 2006-03-07 Gen-Probe Incorporated Oligonucleotides for nucleic acid amplification and for the detection of Mycobacterium tuberculosis
US5545522A (en) * 1989-09-22 1996-08-13 Van Gelder; Russell N. Process for amplifying a target polynucleotide sequence using a single primer-promoter complex
US7049102B1 (en) 1989-09-22 2006-05-23 Board Of Trustees Of Leland Stanford University Multi-gene expression profile
US5194370A (en) * 1990-05-16 1993-03-16 Life Technologies, Inc. Promoter ligation activated transcription amplification of nucleic acid sequences
GB9024005D0 (en) * 1990-11-05 1990-12-19 British Bio Technology Process for amplifying nucleic acid
WO1992018521A1 (en) * 1991-04-10 1992-10-29 Life Technologies, Inc. Method for amplifying and altering an rna sequence
US5981179A (en) * 1991-11-14 1999-11-09 Digene Diagnostics, Inc. Continuous amplification reaction
AU681082B2 (en) * 1992-05-06 1997-08-21 Gen-Probe Incorporated Nucleic acid sequence amplification method, composition and kit
US5612200A (en) * 1992-06-24 1997-03-18 Gen-Probe Incorporated Method and kit for destroying ability of nucleic acid to be amplified
WO1994002642A1 (en) * 1992-07-17 1994-02-03 Aprogenex, Inc. Background-reducing compounds for probe-mediated in-situ fluorimetric assays
US5521061A (en) * 1992-07-17 1996-05-28 Aprogenex, Inc. Enhancement of probe signal in nucleic acid-mediated in-situ hybridization studies
US5502177A (en) * 1993-09-17 1996-03-26 Gilead Sciences, Inc. Pyrimidine derivatives for labeled binding partners
US6890712B1 (en) * 1993-09-22 2005-05-10 Bioveris Corporation Cycling DNA/RNA amplification electrochemiluminescent probe assay
GB2284209A (en) * 1993-11-25 1995-05-31 Ole Buchardt Nucleic acid analogue-induced transcription of RNA from a double-stranded DNA template
EP1251182A3 (de) 1993-12-01 2002-11-27 Toyo Boseki Kabushiki Kaisha Verfahren zur Amplifikation und Erkennung von Nukleinsäure-Zielsequenzen unter Verwendung von thermostabilen Enzymen
US6071699A (en) 1996-06-07 2000-06-06 California Institute Of Technology Nucleic acid mediated electron transfer
FR2714062B1 (fr) * 1993-12-22 1996-02-16 Bio Merieux Promoteur modifié pour ARN polymérase, sa préparation et ses applications.
US20050123926A1 (en) * 1994-01-13 2005-06-09 Enzo Diagnostics, Inc., In vitro process for producing multiple nucleic acid copies
US20110097791A1 (en) * 1999-04-16 2011-04-28 Engelhardt Dean L Novel process, construct and conjugate for producing multiple nucleic acid copies
CA2140081C (en) 1994-01-13 2008-04-01 Dean L. Engelhardt Process, construct and conjugate for producing multiple nucleic acid copies
US6986985B1 (en) 1994-01-13 2006-01-17 Enzo Life Sciences, Inc. Process for producing multiple nucleic acid copies in vivo using a protein-nucleic acid construct
KR100230718B1 (ko) * 1994-03-16 1999-11-15 다니엘 엘. 캐시앙, 헨리 엘. 노르호프 등온 가닥 변위 핵산 증폭법
DE69524105T2 (de) * 1994-07-15 2002-07-18 Organon Teknika B.V., Boxtel Verwendung von rna-polymerase zur verbesserung von nukeinsaeure-amplifikationsverfahren
US5500341A (en) 1994-09-19 1996-03-19 Becton, Dickinson And Company Species-specific detection of Mycobacterium kansasii
FR2724934B1 (fr) * 1994-09-26 1997-01-24 Bio Merieux Oligonucleotide chimere et son utilisation dans l'obtention de transcrits d'un acide nucleique
FR2726277B1 (fr) 1994-10-28 1996-12-27 Bio Merieux Oligonucleotide utilisable comme amorce dans une methode d'amplification basee sur une replication avec deplacement de brin
CA2204355C (en) 1994-11-02 2001-01-16 Gail Mandel Peripheral nervous system specific sodium channels, dna encoding therefor, crystallization, x-ray diffraction, computer molecular modeling, rational drug design, drug screening, and methods of making and using thereof
US5789169A (en) * 1994-11-03 1998-08-04 Regents Of The University Of California Methods for the diagnosis of glaucoma
US5606043A (en) 1994-11-03 1997-02-25 The Regents Of The University Of California Methods for the diagnosis of glaucoma
US5849879A (en) * 1994-11-03 1998-12-15 The Regents Of The University Of California Methods for the diagnosis of glaucoma
US5665545A (en) * 1994-11-28 1997-09-09 Akzo Nobel N.V. Terminal repeat amplification method
IL114615A0 (en) 1995-07-16 1995-11-27 Yeda Res & Dev Modulators of the function of fas receptors and other proteins
CA2139070C (en) * 1994-12-23 2010-03-30 Burton W. Blais Method for enhancing detection ability of nucleic acid assays employing polymerase chain reaction
US5925518A (en) * 1995-05-19 1999-07-20 Akzo Nobel N.V. Nucleic acid primers for amplification of a mycobacteria RNA template
US5710029A (en) * 1995-06-07 1998-01-20 Gen-Probe Incorporated Methods for determining pre-amplification levels of a nucleic acid target sequence from post-amplification levels of product
US5705365A (en) * 1995-06-07 1998-01-06 Gen-Probe Incorporated Kits for determining pre-amplification levels of a nucleic acid target sequence from post-amplification levels of product
JPH11509100A (ja) * 1995-07-13 1999-08-17 イムノロジカル アソシエーツ オブ デンバー 核酸抽出、増幅および検出を統合する自己充足装置
WO1997019193A2 (en) 1995-11-21 1997-05-29 Yale University Unimolecular segment amplification and detection
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
US6048688A (en) * 1996-11-12 2000-04-11 Kimberly-Clark Corporation Method for detection of Pseudomonas aeruginosa using polymerase chain reaction
WO1997035026A1 (en) * 1996-03-18 1997-09-25 Molecular Biology Resources, Inc. Target nucleic acid sequence amplification
US5712127A (en) 1996-04-29 1998-01-27 Genescape Inc. Subtractive amplification
US5876992A (en) 1996-07-03 1999-03-02 Molecular Biology Resources, Inc. Method and formulation for stabilization of enzymes
US7014992B1 (en) * 1996-11-05 2006-03-21 Clinical Micro Sensors, Inc. Conductive oligomers attached to electrodes and nucleoside analogs
US6096273A (en) * 1996-11-05 2000-08-01 Clinical Micro Sensors Electrodes linked via conductive oligomers to nucleic acids
US7381525B1 (en) * 1997-03-07 2008-06-03 Clinical Micro Sensors, Inc. AC/DC voltage apparatus for detection of nucleic acids
US6025133A (en) * 1996-12-30 2000-02-15 Gen-Probe Incorporated Promoter-sequestered oligonucleoside and method of use
US6475724B1 (en) 1997-01-28 2002-11-05 The Regents Of The University Of California Nucleic acids, kits, and methods for the diagnosis, prognosis and treatment of glaucoma and related disorders
US6171788B1 (en) 1997-01-28 2001-01-09 The Regents Of The University Of California Methods for the diagnosis, prognosis and treatment of glaucoma and related disorders
US7138511B1 (en) 1997-01-28 2006-11-21 The Regents Of The University Of California Nucleic acids, kits and methods for the diagnosis, prognosis and treatment of glaucoma and related disorders
ES2271994T3 (es) * 1997-05-02 2007-04-16 Gen-Probe Incorporated Hibridacion en dos pasos y captura de un polinucleotido.
US6534273B2 (en) 1997-05-02 2003-03-18 Gen-Probe Incorporated Two-step hybridization and capture of a polynucleotide
US6214563B1 (en) 1997-08-01 2001-04-10 Aurora Biosciences Corporation Photon reducing agents for reducing undesired light emission in assays
US6221612B1 (en) * 1997-08-01 2001-04-24 Aurora Biosciences Corporation Photon reducing agents for use in fluorescence assays
US6200762B1 (en) 1997-08-01 2001-03-13 Aurora Biosciences Corporation Photon reducing agents and compositions for fluorescence assays
US6489110B1 (en) * 1998-01-23 2002-12-03 bioMérieux, B.V. EF-Tu mRNA as a marker for viability of bacteria
EP1051517A2 (de) * 1998-01-27 2000-11-15 Clinical Micro Sensors, Inc. Amplifizierung von nukleinsäuren mit elektronischer erkennung
US6686150B1 (en) * 1998-01-27 2004-02-03 Clinical Micro Sensors, Inc. Amplification of nucleic acids with electronic detection
US7087148B1 (en) 1998-06-23 2006-08-08 Clinical Micro Sensors, Inc. Binding acceleration techniques for the detection of analytes
US20050244954A1 (en) * 1998-06-23 2005-11-03 Blackburn Gary F Binding acceleration techniques for the detection of analytes
JP4438110B2 (ja) * 1998-07-01 2010-03-24 東ソー株式会社 標的核酸の定量方法
US6908770B1 (en) 1998-07-16 2005-06-21 Board Of Regents, The University Of Texas System Fluid based analysis of multiple analytes by a sensor array
US6316229B1 (en) 1998-07-20 2001-11-13 Yale University Single molecule analysis target-mediated ligation of bipartite primers
US6287824B1 (en) 1998-09-15 2001-09-11 Yale University Molecular cloning using rolling circle amplification
CA2342837A1 (en) 1998-09-15 2000-03-23 Yale University Artificial long terminal repeat vectors
AU769964B2 (en) * 1998-11-27 2004-02-12 Synaptics (Uk) Limited Position sensor
US6531302B1 (en) * 1999-04-12 2003-03-11 Nanogen/Becton Dickinson Partnership Anchored strand displacement amplification on an electronically addressable microchip
US6326173B1 (en) 1999-04-12 2001-12-04 Nanogen/Becton Dickinson Partnership Electronically mediated nucleic acid amplification in NASBA
WO2000062036A1 (en) * 1999-04-12 2000-10-19 Nanogen/Becton Dickinson Partnership Amplification and separation of nucleic acid sequences using strand displacement amplification and bioelectronic microchip technology
US6238868B1 (en) * 1999-04-12 2001-05-29 Nanogen/Becton Dickinson Partnership Multiplex amplification and separation of nucleic acid sequences using ligation-dependant strand displacement amplification and bioelectronic chip technology
EP1196630B2 (de) 1999-04-20 2018-10-17 Illumina, Inc. Detektion von nukleinsäurereaktionen auf kügelchen-arrays
US20030207295A1 (en) * 1999-04-20 2003-11-06 Kevin Gunderson Detection of nucleic acid reactions on bead arrays
US20060275782A1 (en) 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
US8080380B2 (en) * 1999-05-21 2011-12-20 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
US8481268B2 (en) 1999-05-21 2013-07-09 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
US6132997A (en) * 1999-05-28 2000-10-17 Agilent Technologies Method for linear mRNA amplification
CA2379130A1 (en) 1999-07-16 2001-01-25 Board Of Regents, The University Of Texas System Method and apparatus for the delivery of samples to a chemical sensor array
US7022517B1 (en) 1999-07-16 2006-04-04 Board Of Regents, The University Of Texas System Method and apparatus for the delivery of samples to a chemical sensor array
CA2378408C (en) 1999-07-23 2010-07-06 Gen-Probe Incorporated Polynucleotide amplification method
EP1218541B1 (de) 1999-07-26 2008-12-10 Clinical Micro Sensors, Inc. Nukelinsäuresequenzbestimmung mittels elektronischem nachweis
CN1373812B (zh) 1999-09-13 2012-04-11 纽亘技术公司 用于多核苷酸序列线性等温扩增的方法及组合物
US6692918B2 (en) 1999-09-13 2004-02-17 Nugen Technologies, Inc. Methods and compositions for linear isothermal amplification of polynucleotide sequences
AU1472501A (en) * 1999-11-05 2001-05-14 Gerigene Medical Corporation Augmentation and repair of age-related soft tissue defects
US20090074729A2 (en) * 1999-11-05 2009-03-19 Donald Kleinsek Augmentation and repair of spincter defects with cells including fibroblasts
US6361958B1 (en) * 1999-11-12 2002-03-26 Motorola, Inc. Biochannel assay for hybridization with biomaterial
US6875619B2 (en) 1999-11-12 2005-04-05 Motorola, Inc. Microfluidic devices comprising biochannels
US6794138B1 (en) * 1999-12-16 2004-09-21 Affymetrix, Inc. Methods of small sample amplification
US6489114B2 (en) 1999-12-17 2002-12-03 Bio Merieux Process for labeling a ribonucleic acid, and labeled RNA fragments which are obtained thereby
US6902891B2 (en) 1999-12-17 2005-06-07 Bio Merieux Process for labeling a nucleic acid
ATE403145T1 (de) * 2000-01-31 2008-08-15 Univ Texas Tragbare vorrichtung mit einer sensor-array- anordnung
US8076063B2 (en) 2000-02-07 2011-12-13 Illumina, Inc. Multiplexed methylation detection methods
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
US20050214825A1 (en) * 2000-02-07 2005-09-29 John Stuelpnagel Multiplex sample analysis on universal arrays
US7955794B2 (en) 2000-09-21 2011-06-07 Illumina, Inc. Multiplex nucleic acid reactions
US7087414B2 (en) 2000-06-06 2006-08-08 Applera Corporation Methods and devices for multiplexing amplification reactions
EP2351853A1 (de) 2000-06-06 2011-08-03 Life Technologies Corporation Methode und Vorrichtungen für multiplex Amplifizierungsreaktionen
US6605451B1 (en) 2000-06-06 2003-08-12 Xtrana, Inc. Methods and devices for multiplexing amplification reactions
US6602400B1 (en) 2000-06-15 2003-08-05 Motorola, Inc. Method for enhanced bio-conjugation events
US20060166227A1 (en) * 2000-06-20 2006-07-27 Stephen Kingsmore Protein expression profiling
WO2002000938A2 (en) * 2000-06-26 2002-01-03 Nugen Technologies, Inc. Methods and compositions for transcription-based nucleic acid amplification
US7846733B2 (en) 2000-06-26 2010-12-07 Nugen Technologies, Inc. Methods and compositions for transcription-based nucleic acid amplification
JP2004502431A (ja) 2000-06-30 2004-01-29 モレキュラー　ステージング，インコーポレイテッド ロリポッププローブを用いたシグナル増幅
WO2002012263A1 (en) * 2000-08-03 2002-02-14 Roche Diagnostics Gmbh Nucleic acid binding compounds containing pyrazolo[3,4-d]pyrimidine analogues of purin-2,6-diamine and their uses
UA81743C2 (uk) 2000-08-07 2008-02-11 Центокор, Инк. МОНОКЛОНАЛЬНЕ АНТИТІЛО ЛЮДИНИ, ЩО СПЕЦИФІЧНО ЗВ'ЯЗУЄТЬСЯ З ФАКТОРОМ НЕКРОЗУ ПУХЛИН АЛЬФА (ФНПα), ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ, ЩО ЙОГО МІСТИТЬ, ТА СПОСІБ ЛІКУВАННЯ РЕВМАТОЇДНОГО АРТРИТУ
US7288390B2 (en) 2000-08-07 2007-10-30 Centocor, Inc. Anti-dual integrin antibodies, compositions, methods and uses
US6902734B2 (en) 2000-08-07 2005-06-07 Centocor, Inc. Anti-IL-12 antibodies and compositions thereof
CA2835978C (en) 2000-09-01 2016-10-11 Gen-Probe Incorporated Amplification of hiv-1 sequences for detection of sequences associated with drug-resistance mutations
US6558929B2 (en) * 2000-09-15 2003-05-06 Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forshung E.V. PCR reaction mixture for fluorescence-based gene expression and gene mutation analyses
EP1399585B1 (de) 2000-10-23 2008-02-20 Gen-Probe Incorporated Zusammensetzungen und methoden zur detektion von humanem immundefizienz virus 2 (hiv-2)
DE60131903T2 (de) * 2000-10-24 2008-11-27 The Board of Trustees of the Leland S. Stanford Junior University, Palo Alto Direkte multiplex charakterisierung von genomischer dna
WO2002038789A1 (en) * 2000-11-10 2002-05-16 Sratagene Methods for preparation of a nucleic acid for analysis
EP1366191A2 (de) 2000-12-11 2003-12-03 Alexion Pharmaceuticals, Inc. 'nested' haarnadelförmige oligonukleotide zur amplifizierung von nukleinsäure
DE60142709D1 (de) * 2000-12-13 2010-09-09 Nugen Technologies Inc Methoden und zusammensetzungen zur generierung einer vielzahl von kopien von nukleinsäuresequenzen und methoden zur detektion derselben
US6794141B2 (en) * 2000-12-22 2004-09-21 Arcturus Bioscience, Inc. Nucleic acid amplification
CA2437558A1 (en) * 2001-01-31 2002-08-08 The Board Of Regents Of The University Of Texas System Method and apparatus for the confinement of materials in a micromachined chemical sensor array
IL153504A0 (en) 2001-03-09 2003-07-06 Nugen Technologies Inc Methods and compositions for amplification of rna sequences
WO2002072773A2 (en) 2001-03-09 2002-09-19 Nugen Technologies, Inc. Methods and compositions for amplification of rna sequences
US6573051B2 (en) * 2001-03-09 2003-06-03 Molecular Staging, Inc. Open circle probes with intramolecular stem structures
US20030092157A1 (en) * 2001-03-16 2003-05-15 Hayden Michael R. Compositions, screening systems and methods for modulating HDL cholesterol and triglyceride levels
US7338805B2 (en) 2001-05-04 2008-03-04 Bio Merieux Labeling reagents, methods for synthesizing such reagents and methods for detecting biological molecules
US20050009101A1 (en) * 2001-05-17 2005-01-13 Motorola, Inc. Microfluidic devices comprising biochannels
WO2004059289A2 (en) * 2001-05-22 2004-07-15 Epicentre Technologies Target-dependent transcription using deletion mutants of n4 rna polymerase
US8137911B2 (en) * 2001-05-22 2012-03-20 Cellscript, Inc. Preparation and use of single-stranded transcription substrates for synthesis of transcription products corresponding to target sequences
AU2002305019A1 (en) * 2001-05-25 2002-12-09 University Of British Columbia Diagnostic methods for cardiovascular disease, low hdl-cholesterol levels, and high triglyceride levels
US7241566B2 (en) * 2001-06-22 2007-07-10 Marshfield Clinic Methods and oligonucleotides for the detection of Salmonella sp., E. coli O157:H7, and Listeria monocytogenes
US9261460B2 (en) 2002-03-12 2016-02-16 Enzo Life Sciences, Inc. Real-time nucleic acid detection processes and compositions
EP1481076A4 (de) 2001-07-12 2005-05-11 Illumina Inc Multiplex-nukleinsäurereaktionen
US20030027196A1 (en) * 2001-08-02 2003-02-06 Barnes Wayne M. Magnesium precipitate methods for magnesium dependent enzymes
TWI335938B (en) * 2001-08-15 2011-01-11 Rna replication and amplification
DE10143106C1 (de) * 2001-09-03 2002-10-10 Artus Ges Fuer Molekularbiolog Vermehrung von Ribonukleinsäuren
US20120077196A9 (en) * 2001-09-03 2012-03-29 Guido Krupp Universal method for selective amplification of mRNAs
US7414111B2 (en) * 2001-09-19 2008-08-19 Alexion Pharmaceuticals, Inc. Engineered templates and their use in single primer amplification
DK1436404T3 (da) * 2001-09-19 2010-03-08 Alexion Pharma Inc Manipulerede templates og deres anvendelse i single-primer amplifikation
US7045319B2 (en) * 2001-10-30 2006-05-16 Ribomed Biotechnologies, Inc. Molecular detection systems utilizing reiterative oligonucleotide synthesis
US20040054162A1 (en) * 2001-10-30 2004-03-18 Hanna Michelle M. Molecular detection systems utilizing reiterative oligonucleotide synthesis
US20030175947A1 (en) * 2001-11-05 2003-09-18 Liu Robin Hui Enhanced mixing in microfluidic devices
US20030119000A1 (en) * 2001-11-05 2003-06-26 Jon Polansky Methods to screen and treat individuals with glaucoma or the propensity to develop glaucoma
CA2467719C (en) 2001-11-14 2015-03-17 Jill Giles-Komar Anti-il-6 antibodies, compositions, methods and uses
DK1458888T3 (da) * 2001-12-10 2011-06-20 Novartis Ag Fremgangsmåder til behandling af psykose og skizofreni baseret på polymorfier i CNTF-genet
AU2003235767A1 (en) 2002-01-08 2003-07-24 Roche Diagnostics Gmbh Use of silica material in an amplification reaction
AU2003208959A1 (en) * 2002-01-30 2003-09-02 Id Biomedical Corporation Methods for detecting vancomycin-resistant microorganisms and compositions therefor
US20060009409A1 (en) 2002-02-01 2006-01-12 Woolf Tod M Double-stranded oligonucleotides
WO2003064626A2 (en) 2002-02-01 2003-08-07 Sequitur, Inc. Double-stranded oligonucleotides
US7553619B2 (en) 2002-02-08 2009-06-30 Qiagen Gmbh Detection method using dissociated rolling circle amplification
EP1484394A4 (de) 2002-02-20 2005-11-09 Sysmex Corp PRIMER ZUR NUKLEINSÄUREAMPLIFIKATION BEIM NACHWEISEN VON HAUSHALTUNGSGEN-mRNA SOWIE TESTVERFAHREN MIT DIESEN PRIMERN
AU2003222269A1 (en) * 2002-03-11 2003-09-29 Nugen Technologies, Inc. Methods for generating double stranded dna comprising a 3' single stranded portion and uses of these complexes for recombination
US9353405B2 (en) 2002-03-12 2016-05-31 Enzo Life Sciences, Inc. Optimized real time nucleic acid detection processes
US7166478B2 (en) * 2002-03-12 2007-01-23 Enzo Life Sciences, Inc., C/O Enzo Biochem, Inc. Labeling reagents and labeled targets, target labeling processes and other processes for using same in nucleic acid determinations and analyses
EP1485503A4 (de) * 2002-03-15 2005-12-28 Arcturus Bioscience Inc Verbesserte nukleinsäureamplifikation
US20040241723A1 (en) * 2002-03-18 2004-12-02 Marquess Foley Leigh Shaw Systems and methods for improving protein and milk production of dairy herds
US7498171B2 (en) 2002-04-12 2009-03-03 Anthrogenesis Corporation Modulation of stem and progenitor cell differentiation, assays, and uses thereof
WO2003090605A2 (en) 2002-04-26 2003-11-06 Board Of Regents, The University Of Texas System Method and system for the detection of cardiac risk factors
AU2003279697A1 (en) * 2002-05-17 2004-02-16 Nugen Technologies, Inc. Methods for fragmentation, labeling and immobilizaton of nucleic acids
US20030219754A1 (en) * 2002-05-23 2003-11-27 Oleksy Jerome E. Fluorescence polarization detection of nucleic acids
EP1513958B1 (de) 2002-06-14 2011-08-10 Gen-Probe Incorporated Zusammensetzungen zum nachweis von hepatitis-b-virus
US20040009574A1 (en) * 2002-07-09 2004-01-15 Nanibhushan Dattagupta Compositions and methods for detecting streptococcus agalactiae capsular polysaccharide synthesis genes
US20040009482A1 (en) * 2002-07-09 2004-01-15 Nanibhushan Dattagupta Compositions and methods for detecting streptococcus agalactiae surface immunogenic protein genes
US20040009483A1 (en) * 2002-07-12 2004-01-15 Ilsley Diane D. Method of linear mRNA amplification using total RNA
US20060073475A1 (en) * 2002-08-09 2006-04-06 Nanibhushan Dattagupta Compositions and methods for detecting pathogenic bacteria expressing chaperonin proteins
AU2003236461B2 (en) 2002-08-29 2009-05-28 Epigenomics Ag Improved method for bisulfite treatment
DE10240868A1 (de) * 2002-09-04 2004-03-18 Artus Gesellschaft für molekularbiologische Diagnostik und Entwicklung mbH Verbesserte Verfahren zur Synthese von Nukleinsäuren
CA2501946C (en) 2002-10-16 2014-12-23 Gen-Probe Incorporated Compositions and methods for detecting west nile virus
CN1738914A (zh) * 2002-11-21 2006-02-22 震源技术公司 使用编码双链启动子一条链的引物的方法
US20040101844A1 (en) * 2002-11-21 2004-05-27 Amorese Douglas A. Methods and compositions for producing linearly amplified amounts of (+) strand RNA
US7597936B2 (en) * 2002-11-26 2009-10-06 University Of Utah Research Foundation Method of producing a pigmented composite microporous material
JP4824312B2 (ja) * 2002-11-26 2011-11-30 ユニバーシティ オブ ユタ リサーチ ファンデーション 微小孔物質、被分析物の局在化及び定量の方法、並びに被分析物の局在化及び定量用物品
JP2006508662A (ja) 2002-12-04 2006-03-16 アプレラ コーポレイション ポリヌクレオチドの多重増幅
US7955795B2 (en) * 2003-06-06 2011-06-07 Qiagen Gmbh Method of whole genome amplification with reduced artifact production
US9487823B2 (en) 2002-12-20 2016-11-08 Qiagen Gmbh Nucleic acid amplification
US7560231B2 (en) * 2002-12-20 2009-07-14 Roche Molecular Systems, Inc. Mannitol and glucitol derivatives
US6977153B2 (en) * 2002-12-31 2005-12-20 Qiagen Gmbh Rolling circle amplification of RNA
US6852494B2 (en) * 2003-01-10 2005-02-08 Linden Technologies, Inc. Nucleic acid amplification
WO2004083806A2 (en) 2003-01-22 2004-09-30 University Of South Florida Autonomous genosensor apparatus and methods for use
JP2006516391A (ja) * 2003-01-29 2006-07-06 エフ．ホフマン−ラ　ロシュ　アーゲー 重亜硫酸塩処理の改良された方法
US6943768B2 (en) 2003-02-21 2005-09-13 Xtellus Inc. Thermal control system for liquid crystal cell
EP2390352A1 (de) 2003-03-18 2011-11-30 Quantum Genetics Ireland Limited Systeme und Methoden zur Erhöhung der Milchproduktion bei Tieren
US20060192960A1 (en) * 2003-03-24 2006-08-31 Rencs Erik V Polarization detection
US8043834B2 (en) 2003-03-31 2011-10-25 Qiagen Gmbh Universal reagents for rolling circle amplification and methods of use
CA2463719A1 (en) * 2003-04-05 2004-10-05 F. Hoffmann-La Roche Ag Nucleotide analogs with six membered rings
CA2521084A1 (en) 2003-04-14 2004-10-28 Nugen Technologies, Inc. Global amplification using a randomly primed composite primer
WO2004094456A2 (en) 2003-04-18 2004-11-04 Becton, Dickinson And Company Immuno-amplification
AU2003229474A1 (en) * 2003-05-09 2004-11-26 Capital Biochip Company, Ltd. Methods and compositions for detecting sars virus
US9708410B2 (en) 2003-05-30 2017-07-18 Janssen Biotech, Inc. Anti-tissue factor antibodies and compositions
FR2855832B1 (fr) 2003-06-03 2007-09-14 Biomerieux Sa Procede de diagnostic et/ou de pronostic d'un syndrome septique
US20040248102A1 (en) 2003-06-03 2004-12-09 Diane Ilsley-Tyree Methods and compositions for performing template dependent nucleic acid primer extension reactions that produce a reduced complexity product
US20040259100A1 (en) * 2003-06-20 2004-12-23 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
US7670810B2 (en) 2003-06-20 2010-03-02 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
US20050181394A1 (en) * 2003-06-20 2005-08-18 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
CN100494399C (zh) * 2003-06-30 2009-06-03 清华大学 一种基于dna芯片的基因分型方法及其应用
US20060057766A1 (en) * 2003-07-08 2006-03-16 Quanxi Jia Method for preparation of semiconductive films
FR2857375B1 (fr) 2003-07-10 2007-11-09 Biomerieux Sa Procede de detection et/ou d'identification de bacteries de genre staphylococcus
JP5576010B2 (ja) 2003-08-04 2014-08-20 ザ・ホスピタル・フォー・シック・チルドレン ラフォラ病遺伝子
US20050059035A1 (en) * 2003-09-09 2005-03-17 Quest Diagnostics Incorporated Methods and compositions for the amplification of mutations in the diagnosis of cystic fibrosis
US7449292B2 (en) * 2003-09-12 2008-11-11 University Of Cincinnati Methods for predicting relative efficacy of a beta blocker therapy based on a B1-adrenergic receptor polymorphism
KR100571817B1 (ko) * 2003-09-19 2006-04-17 삼성전자주식회사 태그 서열에 혼성화하는 검출 프로브를 이용하는 표적핵산의 검출방법
CA2482097C (en) * 2003-10-13 2012-02-21 F. Hoffmann-La Roche Ag Methods for isolating nucleic acids
JP2007521018A (ja) * 2003-10-29 2007-08-02 リボメド バイオテクノロジーズ，インコーポレイテッド 反復的オリゴヌクレオチド合成のための組成物、方法、および検出技術
CA2793127A1 (en) 2003-11-12 2005-05-26 Bayer Healthcare Llc Oligonucleotides and methods for detection of west nile virus
US7501240B2 (en) 2003-12-02 2009-03-10 Roche Molecular Systems, Inc. Method for bisulfite treatment
FR2863275B1 (fr) * 2003-12-09 2007-08-10 Biomerieux Sa Procede pour le diagnostic/pronostic du cancer du sein
ATE549421T1 (de) 2003-12-19 2012-03-15 Gen Probe Inc Zusammensetzungen, verfahren und kits zum nachweis der nukleinsäuren von hiv-1 und hiv-2
US20050136411A1 (en) * 2003-12-22 2005-06-23 Collins Patrick J. Methods and compositions for linear mRNA amplification from small RNA samples
US20050147975A1 (en) * 2003-12-24 2005-07-07 Schembri Carol T. Methods and compositions for amplification of genomic DNA
AU2004311882A1 (en) 2003-12-29 2005-07-21 Nugen Technologies, Inc. Methods for analysis of nucleic acid methylation status and methods for fragmentation, labeling and immobilization of nucleic acids
US20050158710A1 (en) * 2004-01-16 2005-07-21 Shirley Tsang Detection of enterovirus nucleic acid
US20070281294A1 (en) * 2004-02-10 2007-12-06 Roche Moleculr Systems, Inc. Primers And Probes For The Detection Of Parvovirus B19
US20050202484A1 (en) 2004-02-19 2005-09-15 The Governors Of The University Of Alberta Leptin promoter polymorphisms and uses thereof
US8101431B2 (en) 2004-02-27 2012-01-24 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems
US8105849B2 (en) 2004-02-27 2012-01-31 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements
WO2005085475A1 (en) 2004-03-01 2005-09-15 Applera Corporation Methods, compositions and kits for use in polynucleotide amplification
US8338578B1 (en) 2004-03-05 2012-12-25 Quest Diagnostics Investments Incorporated Cystic fibrosis gene mutations
EP1574583A1 (de) * 2004-03-10 2005-09-14 Roche Diagnostics GmbH Verfahren zur Isolierung von Bakterien aus biologischen Proben
FR2868071B1 (fr) 2004-03-26 2006-06-09 Biomerieux Sa Reactifs de marquage, procedes de synthese de tels reactifs et procedes de detection de molecules biologiques
FR2868433B1 (fr) 2004-04-06 2008-01-18 Biomerieux Sa Procede pour le pronostic et/ou le diagnostic d'un cancer
US7229800B2 (en) 2004-04-16 2007-06-12 Becton, Dickinson And Company Neisseria gonorrhoeae assay
EP1758981A4 (de) 2004-05-28 2013-01-16 Wafergen Inc Vorrichtungen und verfahren für multiplex-analysen
US8124334B2 (en) * 2004-07-06 2012-02-28 Enzo Biochem, Inc. Selective detection of oncogenic HPV
AU2005262317B2 (en) 2004-07-13 2009-07-16 Gen-Probe Incorporated Compositions and methods for detection of hepatitis A virus nucleic acid
US7713697B2 (en) * 2004-08-27 2010-05-11 Gen-Probe Incorporated Methods and kits for amplifying DNA
ATE500344T1 (de) * 2004-08-27 2011-03-15 Gen Probe Inc Einfach-primernukleinsäuren-erweiterungsverfahr n
EP1632578A1 (de) 2004-09-03 2006-03-08 Roche Diagnostics GmbH Methode zur Dekontamination der DNA
RU2389798C2 (ru) 2004-09-14 2010-05-20 Дзе Риджентс Оф Дзе Юниверсити Оф Колорадо, Э Боди Корпорейт Способ лечения буциндололом, основанный на определении генотипа
JP2008514731A (ja) 2004-09-30 2008-05-08 ヴァンダ ファーマシューティカルズ インコーポレイテッド イロペリドンの投与方法
US20100063093A1 (en) * 2007-03-28 2010-03-11 Curt Wolfgang Methods for the administration of iloperidone
CA2929741A1 (en) 2004-09-30 2006-04-13 Gen-Probe Incorporated Assay for detecting and quantifying hiv-1
CA2582661C (en) * 2004-11-09 2015-08-11 Gen-Probe Incorporated Compositions and methods for detecting group a streptococci
WO2006065442A2 (en) * 2004-12-17 2006-06-22 Ventana Medical Systems, Inc. Methods and compositions for a microemulsion-based tissue treatment
EP1841879A4 (de) 2005-01-25 2009-05-27 Population Genetics Technologi Isothermische dna-amplifikation
FR2881437B1 (fr) 2005-01-31 2010-11-19 Biomerieux Sa Procede pour le diagnostic/pronostic d'un syndrome septique
US20060177859A1 (en) * 2005-02-07 2006-08-10 Gen-Probe Incorporated Compositions and methods for detecting group B streptococci
US20090124993A1 (en) 2005-02-17 2009-05-14 Burkly Linda C Treating neurological disorders
WO2006089154A1 (en) 2005-02-18 2006-08-24 Gen-Probe Incorporated Sample preparation method incorporating an alkaline shock
US9127305B2 (en) * 2005-02-28 2015-09-08 Bioquest, Inc. Methods for performing direct enzymatic reactions involving nucleic acid molecules
KR100977186B1 (ko) 2005-03-05 2010-08-23 주식회사 씨젠 이중 특이성 올리고뉴클레오타이드를 사용한 방법 및 이중특이성 올리고뉴클레오타이드
WO2006095941A1 (en) 2005-03-05 2006-09-14 Seegene, Inc. Processes using dual specificity oligonucleotide and dual specificity oligonucleotide
JP4398886B2 (ja) * 2005-03-07 2010-01-13 ソニー株式会社 通信端末装置、通信システム、通信方法、およびプログラム
EP1921454B1 (de) 2005-03-10 2015-08-12 Gen-Probe Incorporated Systeme und Verfahren zur Durchführung von Tests zum Nachweis oder zur Quantifizierung von Analyten
EP1700922B1 (de) 2005-03-10 2016-08-24 Roche Diagnostics GmbH 3-Substituierte 5-Nitroindolderivate und diese enthaltende markierte Oligonukleotidsonden
CA2842232C (en) 2005-03-10 2015-01-27 Gen-Probe Incorporated Systems and methods to perform assays for detecting or quantifying analytes within samples
US7759469B2 (en) 2005-03-10 2010-07-20 Roche Diagnostics Operations, Inc. Labeling reagent
JP4658660B2 (ja) * 2005-03-30 2011-03-23 株式会社日立ハイテクノロジーズ 核酸検出法
ES2440953T3 (es) 2005-03-31 2014-01-31 The General Hospital Corporation Modulación de la actividad de HGF/HGFR para tratar un linfedema
US8309303B2 (en) 2005-04-01 2012-11-13 Qiagen Gmbh Reverse transcription and amplification of RNA with simultaneous degradation of DNA
US20060223071A1 (en) * 2005-04-01 2006-10-05 Wisniewski Michele E Methods, compositions, and kits for detecting nucleic acids in a single vessel
US20060240442A1 (en) * 2005-04-20 2006-10-26 Vevea Dirk N Methods and oligonucleotides for the detection of Salmonella SP., E coli 0157:H7, and Listeria monocytogenes
PA8672101A1 (es) 2005-04-29 2006-12-07 Centocor Inc Anticuerpos anti-il-6, composiciones, métodos y usos
EP1877418B1 (de) 2005-05-06 2013-11-20 Gen-Probe Incorporated Zusammensetzungen und testanordnungen zur erkennung von nukleinsäuren des influenza-virus a
NZ564141A (en) 2005-05-09 2011-02-25 Theranos Inc Two way communication system for monitoring an analyte
ATE545701T1 (de) 2005-05-17 2012-03-15 Ozgene Pty Ltd Sequentielles klonierungssystem
US8377398B2 (en) 2005-05-31 2013-02-19 The Board Of Regents Of The University Of Texas System Methods and compositions related to determination and use of white blood cell counts
FR2886735B1 (fr) 2005-06-01 2015-09-11 Biomerieux Sa Procede de marquage ou de traitement d'un echantillon biologique contenant des molecules biologiques d'interet, notamment des acides nucleiques
US7550264B2 (en) 2005-06-10 2009-06-23 Datascope Investment Corporation Methods and kits for sense RNA synthesis
AU2006261953B2 (en) * 2005-06-24 2012-02-23 Board Of Regents, The University Of Texas System Systems and methods including self-contained cartridges with detection systems and fluid delivery systems
SI1896073T1 (sl) 2005-06-30 2013-06-28 Janssen Biotech, Inc. Protitelesa proti il-23, sestavki, prostopki in uporabe
US7838646B2 (en) 2005-08-18 2010-11-23 Quest Diagnostics Investments Incorporated Cystic fibrosis transmembrane conductance regulator gene mutations
EP1929045B9 (de) * 2005-09-06 2012-06-20 Gen-Probe Incorporated Verfahren, zusammensetzungen und kits zur isothermischen amplifikation von nukleinsäuren
WO2007030759A2 (en) 2005-09-07 2007-03-15 Nugen Technologies, Inc. Improved nucleic acid amplification procedure
EP1762627A1 (de) 2005-09-09 2007-03-14 Qiagen GmbH Verfahren zur Aktivierung einer Nukleinsäure für eine Polymerase-Reaktion
US9957569B2 (en) * 2005-09-12 2018-05-01 The Regents Of The University Of Michigan Recurrent gene fusions in prostate cancer
CA2622295C (en) 2005-09-12 2019-01-15 The Regents Of The University Of Michigan Recurrent gene fusions in prostate cancer
WO2007044671A2 (en) * 2005-10-06 2007-04-19 Lucigen Corporation Thermostable viral polymerases and methods of use
AU2006304721B2 (en) 2005-10-17 2012-01-19 Gen-Probe Incorporated Compositions and methods to detect Legionella pneumophila nucleic acid
JP2009514549A (ja) 2005-11-07 2009-04-09 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッド Ｃｈｌａｍｙｄｉａｔｒａｃｈｏｍａｔｉｓ特異的オリゴヌクレオチド配列
AU2006315489B2 (en) 2005-11-14 2012-09-06 Gen-Probe Incorporated Parametric calibration method
AU2006314528A1 (en) 2005-11-16 2007-05-24 Novartis Ag Biomarkers for anti-nogo-A antibody treatment in spinal cord injury
EP1788389A1 (de) 2005-11-18 2007-05-23 Universitat De Girona Verfahren zum spezifischen Nachweis von Legionella pneumophila
FR2902430B1 (fr) 2005-11-25 2012-11-02 Biomerieux Sa Oligonucleotides, utilisation, methode de detection et kit permettant de diagnostiquer la presence des genes h5 et n1 du virus d'influenza a
US7981606B2 (en) * 2005-12-21 2011-07-19 Roche Molecular Systems, Inc. Control for nucleic acid testing
EP2548577B1 (de) 2005-12-29 2017-02-15 Janssen Biotech, Inc. Humane anti-il-23-antikörper, zusammensetzungen, verfahren und verwendungen
US8030080B2 (en) 2006-01-18 2011-10-04 Argos Therapeutics, Inc. Systems and methods for processing samples in a closed container, and related devices
WO2007087262A2 (en) * 2006-01-23 2007-08-02 Population Genetics Technologies Ltd. Selective genome amplification
AU2007225038B2 (en) * 2006-03-15 2013-08-29 Revvity Health Sciences, Inc. Integrated nucleic acid assays
US8741230B2 (en) 2006-03-24 2014-06-03 Theranos, Inc. Systems and methods of sample processing and fluid control in a fluidic system
US11287421B2 (en) 2006-03-24 2022-03-29 Labrador Diagnostics Llc Systems and methods of sample processing and fluid control in a fluidic system
US7790386B2 (en) 2006-04-07 2010-09-07 Siemens Healthcare Diagnostics Inc. Neisseria gonorrhoeae specific oligonucleotide sequences
US8007999B2 (en) 2006-05-10 2011-08-30 Theranos, Inc. Real-time detection of influenza virus
CA2651946A1 (en) * 2006-05-12 2007-11-22 Gen-Probe Incorporated Compositions and methods to detect enterococci nucleic acid
CA2740917C (en) 2006-05-25 2013-01-08 Monsanto Technology Llc A method to identify disease resistant quantitative trait loci in soybean and compositions thereof
US7897747B2 (en) * 2006-05-25 2011-03-01 The Board Of Trustees Of The Leland Stanford Junior University Method to produce single stranded DNA of defined length and sequence and DNA probes produced thereby
US11001881B2 (en) 2006-08-24 2021-05-11 California Institute Of Technology Methods for detecting analytes
DE602007012045D1 (de) 2006-06-06 2011-03-03 Gen Probe Inc Markierte oligonukleotide und ihre verwendung in nukleinsäureverstärkungsverfahren
US20100022403A1 (en) * 2006-06-30 2010-01-28 Nurith Kurn Methods for fragmentation and labeling of nucleic acids
US8048626B2 (en) 2006-07-28 2011-11-01 California Institute Of Technology Multiplex Q-PCR arrays
US11525156B2 (en) 2006-07-28 2022-12-13 California Institute Of Technology Multiplex Q-PCR arrays
US9051601B2 (en) 2006-08-01 2015-06-09 Gen-Probe Incorporated Methods of nonspecific target capture of nucleic acids
JP5244103B2 (ja) 2006-08-09 2013-07-24 ホームステッド クリニカル コーポレイション 器官特異的蛋白質およびその使用方法
US11560588B2 (en) 2006-08-24 2023-01-24 California Institute Of Technology Multiplex Q-PCR arrays
US20080261216A1 (en) * 2006-09-08 2008-10-23 The Regents Of The University Of Michigan HERV Group II Viruses In Lymphoma And Cancer
FR2906537A1 (fr) 2006-09-28 2008-04-04 Biomerieux Sa Procede de diagnostic in vitro du cancer broncho-pulmonaire par detection des transcrits majoritaires alternatifs du gene klk8 codant la kallicreine 8 et son utilisation pour le pronostic de survie
US8012744B2 (en) 2006-10-13 2011-09-06 Theranos, Inc. Reducing optical interference in a fluidic device
US8338109B2 (en) 2006-11-02 2012-12-25 Mayo Foundation For Medical Education And Research Predicting cancer outcome
US20080113391A1 (en) 2006-11-14 2008-05-15 Ian Gibbons Detection and quantification of analytes in bodily fluids
US7492312B2 (en) * 2006-11-14 2009-02-17 Fam Adly T Multiplicative mismatched filters for optimum range sidelobe suppression in barker code reception
CA2614069C (en) 2006-12-11 2016-05-03 F. Hoffmann-La Roche Ag Nucleic acid isolation using polidocanol and derivatives
EP1932913B1 (de) 2006-12-11 2013-01-16 Roche Diagnostics GmbH Nukleinsäureisolation mithilfe von Polidocanol und Derivaten davon
WO2008080029A2 (en) 2006-12-21 2008-07-03 Gen-Probe Incorporated Methods and compositions for nucleic acid amplification
US7794937B2 (en) 2006-12-22 2010-09-14 Quest Diagnostics Investments Incorporated Cystic fibrosis transmembrane conductance regulator gene mutations
GB0701253D0 (en) 2007-01-23 2007-02-28 Diagnostics For The Real World Nucleic acid amplification and testing
US8183359B2 (en) * 2007-03-01 2012-05-22 Gen-Probe Incorporated Kits for amplifying DNA
EP1978111B1 (de) 2007-04-02 2013-03-27 Gen-Probe Incorporated Zusammensetzungen, Kits und zugehörige Verfahren zur Erkennung und/oder Überwachung von Pseudomonas aeruginosa
CA2629589C (en) * 2007-04-20 2016-03-29 F.Hoffmann-La Roche Ag Isolation and purification of nucleic acid molecules with a solid phase
FR2917090B1 (fr) 2007-06-11 2012-06-15 Biomerieux Sa Reactifs de marquage portant des fonctions diazo et nitro, procedes de synthese de tels reactifs et procedes de detection de molecules biologiques
WO2008157801A2 (en) 2007-06-21 2008-12-24 Gen-Probe Incorporated Instrument and receptacles for performing processes
CA2707436C (en) 2007-06-29 2014-01-28 Epicentre Technologies Corporation Copy dna and sense rna
US9303291B2 (en) 2007-07-06 2016-04-05 The Regents Of The University Of Michigan MIPOL1-ETV1 gene rearrangements
EP3018216B1 (de) 2007-07-06 2018-09-12 The Regents Of The University Of Michigan Rezidivierende genfusionen bei prostatakrebs
US8158430B1 (en) 2007-08-06 2012-04-17 Theranos, Inc. Systems and methods of fluidic sample processing
WO2009029648A2 (en) 2007-08-27 2009-03-05 Applera Corporation Methods and compositions for pcr
ES2447875T3 (es) 2007-10-02 2014-03-13 Theranos, Inc. Dispositivos modulares para punto de cuidados y usos de los mismos
WO2009049268A1 (en) 2007-10-12 2009-04-16 Rheonix, Inc. Integrated microfluidic device and methods
WO2009061640A2 (en) * 2007-11-06 2009-05-14 Siemens Healthcare Diagnostics Inc. Hepatitis b virus (hbv) specific oligonucleotide sequences
EP2071034A1 (de) 2007-12-12 2009-06-17 bioMérieux Verfahren zur Behandlung einer Lösung zum Vernichten von Ribonukleinsäure nach der Amplifikation
ES2425267T5 (es) 2007-12-21 2022-07-13 Biomerieux Sa Detección de Staphylococcus aureus resistente a meticilina
EP2235214B1 (de) * 2007-12-26 2014-07-09 Gen Probe Inc Zusammensetzungen und verfahren für den nachweis von candida albicans-nukleinsäure
US20090203531A1 (en) * 2008-02-12 2009-08-13 Nurith Kurn Method for Archiving and Clonal Expansion
US20090215050A1 (en) 2008-02-22 2009-08-27 Robert Delmar Jenison Systems and methods for point-of-care amplification and detection of polynucleotides
US7846666B2 (en) 2008-03-21 2010-12-07 Nugen Technologies, Inc. Methods of RNA amplification in the presence of DNA
JP2011518126A (ja) * 2008-03-25 2011-06-23 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン ＩＫＫｉ阻害剤の処置方法およびスクリーニング方法、ならびに関連するＩＫＫｉ診断方法
EP2108699B1 (de) 2008-04-08 2014-06-25 F.Hoffmann-La Roche Ag Vorrichtung zur analytischen Verarbeitung und Detektion
CA3128538C (en) 2008-04-21 2023-08-08 Gen-Probe Incorporated Method for detecting chikungunya virus
JP2009268665A (ja) * 2008-05-07 2009-11-19 Canon Inc 吸入装置
EP2806037B1 (de) 2008-05-13 2016-09-21 Gen-Probe Incorporated Inaktivierbare Target-Capture-Oligomere zur Verwendung bei der selektiven Hybridisierung und beim Fangen von Zielnukleinsäuresequenzen
WO2009140666A2 (en) 2008-05-15 2009-11-19 Ribomed Biotechnologies, Inc. METHODS AND REAGENTS FOR DETECTING CpG METHYLATION WITH A METHYL CpG BINDING PROTEIN (MBP)
EP2291553A4 (de) 2008-05-28 2011-12-14 Genomedx Biosciences Inc Systeme und verfahren zur expressionsbasierten unterscheidung unterschiedlicher klinischer krankheitsstadien bei prostatakrebs
CA2723917A1 (en) 2008-05-30 2009-12-30 Gen-Probe Incorporated Compositions, kits and related methods for the detection and/or monitoring of salmonella
US10407731B2 (en) 2008-05-30 2019-09-10 Mayo Foundation For Medical Education And Research Biomarker panels for predicting prostate cancer outcomes
ES2439951T3 (es) 2008-06-06 2014-01-27 F. Hoffmann-La Roche Ag Detección y cuantificación multiplex de ácidos nucleicos microbianos controlada de forma interna
WO2010009060A2 (en) * 2008-07-13 2010-01-21 Ribomed Biotechnologies, Inc. Molecular beacon-based methods for detection of targets using abscription
FR2934595B1 (fr) 2008-07-29 2013-04-05 Biomerieux Sa Reactifs de marquage ayant un noyau pyridine portant une fonction diazomethyle, procedes de synthese de tels reactifs et procedes de detection de molecules biologiques
GB0814570D0 (en) 2008-08-08 2008-09-17 Diagnostics For The Real World Isolation of nucleic acid
KR101781965B1 (ko) 2008-08-14 2017-09-27 테바 파마슈티컬즈 오스트레일리아 피티와이 엘티디 항-ｉｌ-12/ｉｌ-23 항체
WO2010030461A2 (en) * 2008-09-12 2010-03-18 Promega Corporation Assessing expression of endogenous and exogenous genes
US8383345B2 (en) 2008-09-12 2013-02-26 University Of Washington Sequence tag directed subassembly of short sequencing reads into long sequencing reads
EP2172563A1 (de) 2008-09-24 2010-04-07 bioMérieux S.A. Verfahren zur Verringerung der Abhängigkeit von Sequenzvariationen eines Nukleinsäuretargets in einem diagnostischen Hybridisierungs-Assay
US9090948B2 (en) 2008-09-30 2015-07-28 Abbott Molecular Inc. Primers and probes for detecting human papillomavirus and human beta globin sequences in test samples
EP2177271B8 (de) 2008-10-15 2019-12-18 F. Hoffmann-La Roche AG Magnetisches Trennsystem mit flexiblen magnetischen Stiften und zugehöriges Verfahren
CA2742074A1 (en) * 2008-10-29 2010-08-26 Janssen Pharmaceutica Nv Methods of treating psychosis and schizophrenia based on polymorphisms in the erbb4 gene
CN102307896B (zh) 2008-10-31 2016-10-12 森托科尔奥索生物科技公司 基于iii型纤连蛋白结构域的支架组合物、方法及用途
EP2189218A1 (de) 2008-11-12 2010-05-26 F. Hoffmann-Roche AG Trennung in einer Mikrowell platte unter Zuhilfenahme des Deckels
US9495515B1 (en) 2009-12-09 2016-11-15 Veracyte, Inc. Algorithms for disease diagnostics
US10236078B2 (en) 2008-11-17 2019-03-19 Veracyte, Inc. Methods for processing or analyzing a sample of thyroid tissue
EP2389449B1 (de) 2008-12-30 2015-02-18 Gen-Probe Incorporated Zusammensetzungen, kits und damit verbundene verfahren zum nachweis und/oder überwachen von listerien
FR2940805B1 (fr) 2009-01-05 2015-10-16 Biomerieux Sa Procede d'amplification et/ou de detection d'acides nucleiques, kits et utilisations de ce procede
CA2749113A1 (en) 2009-01-09 2010-07-15 The Regents Of The University Of Michigan Recurrent gene fusions in cancer
CA2750900C (en) 2009-01-30 2017-03-28 Gen-Probe Incorporated Systems and methods for detecting a signal and applying thermal energy to a signal transmission element
CN102596992B (zh) 2009-02-12 2015-09-09 詹森生物科技公司 基于ⅲ型纤连蛋白结构域的支架组合物、方法及用途
CA2756659A1 (en) 2009-02-26 2010-09-02 Gen-Probe Incorporated Assay for detection of human parvovirus nucleic acid
US9074258B2 (en) 2009-03-04 2015-07-07 Genomedx Biosciences Inc. Compositions and methods for classifying thyroid nodule disease
EP2408935A4 (de) 2009-03-15 2012-10-03 Ribomed Biotechnologies Inc Molekülerkennung auf basis abortiver transkription
US9393564B2 (en) 2009-03-30 2016-07-19 Ibis Biosciences, Inc. Bioagent detection systems, devices, and methods
WO2010126913A1 (en) 2009-04-27 2010-11-04 Gen-Probe Incorporated Methods and kits for use in the selective amplification of target sequences
JP6078339B2 (ja) 2009-05-07 2017-02-08 ベラサイト インコーポレイテッド 甲状腺状態の診断のための方法および組成物
EP2446057B1 (de) 2009-06-23 2014-11-19 Gen-Probe Incorporated Zusammensetzungen und verfahren für den nukleinsäurenachweis aus mollicutes
CA2766391C (en) 2009-07-01 2021-04-20 Gen-Probe Incorporated Methods and compositions for multiplex nucleic acid amplification
JP5575239B2 (ja) * 2009-07-21 2014-08-20 ジェン−プローブ・インコーポレーテッド 拡張されたダイナミックレンジにわたる核酸配列の定量的検出のための方法および組成物
US8614062B1 (en) 2009-07-24 2013-12-24 University Of South Florida RNA-based system and method to differentiate seafood
US20110059453A1 (en) * 2009-08-23 2011-03-10 Affymetrix, Inc. Poly(A) Tail Length Measurement by PCR
WO2011026139A1 (en) 2009-08-31 2011-03-03 Gen-Probe Incorporated Dengue virus assay
US9512481B2 (en) 2009-09-11 2016-12-06 The Regents Of The University Of Colorado, A Body Corporate Polymorphisms in the PDE3A gene
JP5800817B2 (ja) * 2009-09-17 2015-10-28 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 前立腺癌における再発性遺伝子融合
FR2950358B1 (fr) 2009-09-18 2015-09-11 Biomerieux Sa Dispositif d'amplification d'acides nucleiques simplifie et son procede de mise en oeuvre
CA3081708C (en) 2009-10-19 2023-10-03 Theranos Ip Company, Llc Integrated health data capture and analysis system
CN102858962A (zh) 2009-11-19 2013-01-02 索利斯拜欧代因公司 用于增加多肽稳定性和活性的组合物及相关方法
CN102648295B (zh) 2009-12-07 2017-08-08 伊鲁米那股份有限公司 用于多重基因分型的多样品索引
US10446272B2 (en) 2009-12-09 2019-10-15 Veracyte, Inc. Methods and compositions for classification of samples
WO2011079273A2 (en) 2009-12-23 2011-06-30 Arca Biopharma, Inc. Methods and compositions for cardiovascular diseases and conditions
US20110165568A1 (en) 2009-12-31 2011-07-07 Life Technologies Corporation Sequences of e.coli 055:h7 genome
EP2529026B1 (de) 2010-01-25 2013-11-13 Rd Biosciences Inc. Selbstfaltende amplifikation einer zielnukleinsäure
EP2528687B1 (de) 2010-01-29 2018-08-22 Micronics, Inc. System beinhaltend ein wirtinstrument und eine mikrofluidische kartusche für untersuchungen
EP3604558B1 (de) 2010-02-17 2022-10-12 Gen-Probe Incorporated Zusammensetzungen und verfahren zum nachweis von atopobium-vaginae-nukleinsäure
WO2011123507A1 (en) 2010-03-30 2011-10-06 Centocor Ortho Biotech Inc. Humanized il-25 antibodies
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
ES2555106T3 (es) 2010-04-05 2015-12-29 Prognosys Biosciences, Inc. Ensayos biológicos codificados espacialmente
EP3587593B1 (de) 2010-04-21 2023-09-27 Gen-Probe Incorporated Zusammensetzungen, verfahren und kits für den nachweis von nukleinsäuren des herpes-simplex-virus
AU2011248625B2 (en) 2010-04-26 2017-01-05 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-tRNA synthetase
CN103096911B (zh) 2010-04-27 2018-05-29 Atyr 医药公司 与异亮氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
CN103097524B (zh) 2010-04-28 2016-08-03 Atyr医药公司 与丙氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
US9068177B2 (en) 2010-04-29 2015-06-30 Atyr Pharma, Inc Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-tRNA synthetases
CA2797374C (en) 2010-04-29 2021-02-16 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of asparaginyl trna synthetases
CN103118693B (zh) 2010-04-29 2017-05-03 Atyr 医药公司 与缬氨酰‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
ES2623805T3 (es) 2010-05-03 2017-07-12 Atyr Pharma, Inc. Descubrimiento innovador de composiciones terapéuticas, de diagnóstico y de anticuerpos relacionadas con fragmentos de proteínas de fenilalanil-alfa-ARNt sintetasas
CN103096925A (zh) 2010-05-03 2013-05-08 Atyr医药公司 与精氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
WO2011140135A2 (en) 2010-05-03 2011-11-10 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of methionyl-trna synthetases
AU2011248101B2 (en) 2010-05-04 2016-10-20 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of p38 multi-tRNA synthetase complex
US10232374B2 (en) 2010-05-05 2019-03-19 Miroculus Inc. Method of processing dried samples using digital microfluidic device
US8945541B2 (en) 2010-05-14 2015-02-03 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-beta-tRNA synthetases
KR101176139B1 (ko) 2010-05-20 2012-08-22 광주과학기술원 관절염 동물모델로서 연골 특이적 ＨＩＦ?２α 형질전환 마우스 및 이의 용도
KR101223660B1 (ko) 2010-05-20 2013-01-17 광주과학기술원 ＨＩＦ－２α 억제제를 유효성분으로 포함하는 관절염 예방 또는 치료용 약제학적 조성물
EP2575857B1 (de) 2010-06-01 2018-01-24 aTyr Pharma, Inc. Innovative erkennung therapeutischer, diagnostischer und antikörperhaltiger zusammensetzungen in zusammenhang mit proteinfragmenten von lysyl-trna-synthetasen
US9422598B2 (en) 2010-06-04 2016-08-23 Biomerieux Method and kit for the prognosis of colorectal cancer
ES2569220T3 (es) 2010-06-22 2016-05-09 F. Hoffmann-La Roche Ag Envase de suspensión para partículas de unión para el aislamiento de material biológico
CA2802741C (en) 2010-06-30 2020-07-07 Gen-Probe Incorporated Method and apparatus for identifying analyte-containing samples using single-read determination of analyte and process control signals
US8790878B2 (en) 2010-07-07 2014-07-29 The Regents Of The University Of Michigan Diagnosis and treatment of breast cancer
EP3301195B1 (de) 2010-07-12 2022-11-02 Gen-Probe Incorporated Zusammensetzungen und assays zur detektion der 2009 h1n1-influenza-a-virus-nukleinsäure in schweinen
CN103118695B (zh) 2010-07-12 2016-08-03 Atyr医药公司 与甘氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的发现
EP2913402B1 (de) 2010-07-16 2017-10-18 Tocagen Inc. Retrovirusdetektion
CN103025891A (zh) 2010-07-29 2013-04-03 霍夫曼-拉罗奇有限公司 通用样品制备
WO2012013731A1 (en) 2010-07-29 2012-02-02 F. Hoffmann - La Roche Ag Qualitative and quantitative detection of microbial nucleic acids
ES2644797T3 (es) 2010-07-29 2017-11-30 F. Hoffmann-La Roche Ag PCR genérica
JP5952275B2 (ja) 2010-07-29 2016-07-13 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 多数のパラメーターのための対照核酸
CA2807552A1 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
US9029506B2 (en) 2010-08-25 2015-05-12 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of tyrosyl-tRNA synthetases
WO2012030856A2 (en) 2010-08-30 2012-03-08 Gen-Probe Incorporated Compositions, methods and reaction mixtures for the detection of xenotropic murine leukemia virus-related virus
EP2426222A1 (de) 2010-09-07 2012-03-07 F. Hoffmann-La Roche AG Generischer Puffer zur Amplifikation
US9110079B2 (en) 2010-09-29 2015-08-18 Biomerieux Method and kit for establishing an in vitro prognosis on a patient exhibiting SIRS
LT4108671T (lt) 2010-10-01 2025-01-10 Modernatx, Inc. Modifikuoti nukleozidai, nukleotidai, nukleorūgštys bei jų panaudojimas
EP3438289A1 (de) 2010-10-04 2019-02-06 Gen-Probe Prodesse, Inc. Zusammensetzungen, verfahren und kits für den nachweis von adenovirus-nukleinsäuren
US10233501B2 (en) 2010-10-19 2019-03-19 Northwestern University Biomarkers predictive of predisposition to depression and response to treatment
US20150218639A1 (en) 2014-01-17 2015-08-06 Northwestern University Biomarkers predictive of predisposition to depression and response to treatment
US20150225792A1 (en) 2014-01-17 2015-08-13 Northwestern University Compositions and methods for identifying depressive disorders
US10093981B2 (en) 2010-10-19 2018-10-09 Northwestern University Compositions and methods for identifying depressive disorders
WO2012054639A2 (en) 2010-10-22 2012-04-26 T2 Biosystems, Inc. Nmr systems and methods for the rapid detection of analytes
US8563298B2 (en) 2010-10-22 2013-10-22 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
ES2659543T3 (es) 2010-11-01 2018-03-16 Becton Dickinson And Company Ensayo de Gardnerella vaginalis
US9074251B2 (en) 2011-02-10 2015-07-07 Illumina, Inc. Linking sequence reads using paired code tags
US20150284802A1 (en) 2010-11-19 2015-10-08 The Regents Of The University Of Michigan ncRNA AND USES THEREOF
US20130267443A1 (en) 2010-11-19 2013-10-10 The Regents Of The University Of Michigan ncRNA AND USES THEREOF
US8945556B2 (en) 2010-11-19 2015-02-03 The Regents Of The University Of Michigan RAF gene fusions
EP2465945A1 (de) 2010-12-17 2012-06-20 F. Hoffmann-La Roche AG Allgemeine Matrix zur Steuerung von Nukleinsäuren
WO2012090073A2 (en) 2010-12-30 2012-07-05 The Netherlands Cancer Institute Methods and compositions for predicting chemotherapy sensitivity
EP4008781A1 (de) 2010-12-31 2022-06-08 BioAtla, Inc. Express-humanisierung von antikörpern
US10670608B2 (en) 2010-12-31 2020-06-02 Bioatla, Llc Comprehensive monoclonal antibody generation
TWI639703B (zh) 2011-01-21 2018-11-01 賽瑞諾斯有限公司 樣本使用最大化之系統及方法
US10457936B2 (en) 2011-02-02 2019-10-29 University Of Washington Through Its Center For Commercialization Massively parallel contiguity mapping
WO2012112558A1 (en) 2011-02-14 2012-08-23 The Regents Of The University Of Michigan Compositions and methods for the treatment of obesity and related disorders
USRE49975E1 (en) 2011-03-10 2024-05-21 Gen-Probe Incorporated Methods and compositions for the selection and optimization of oligonucleotide tag sequences
WO2012129758A1 (en) 2011-03-25 2012-10-04 Biomerieux Method and kit for determining in vitro probability for individual to suffer from colorectal cancer
US8710200B2 (en) 2011-03-31 2014-04-29 Moderna Therapeutics, Inc. Engineered nucleic acids encoding a modified erythropoietin and their expression
WO2012138789A2 (en) 2011-04-04 2012-10-11 Netherlands Cancer Institute Methods and compositions for predicting resistance to anticancer treatment
AU2012240240A1 (en) 2011-04-04 2013-05-09 Netherlands Cancer Institute Methods and compositions for predicting resistance to anticancer treatment with protein kinase inhibitors
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
ES2769028T3 (es) 2011-04-15 2020-06-24 Becton Dickinson Co Termociclador microfluídico de barrido en tiempo real
EP3604559A1 (de) 2011-04-25 2020-02-05 Gen-Probe Incorporated Zusammensetzungen und verfahren zum nachweis von bv-assoziierter bakterieller nukleinsäure
EP2701736A1 (de) 2011-04-25 2014-03-05 Advanced Bioscience Laboratories, Inc. Trunkierte hiv-hüllproteine (env), verfahren und zugehörige zusammensetzungen
EP2535712A1 (de) 2011-06-15 2012-12-19 F. Hoffmann-La Roche AG Analytisches System zur Herstellung eines biologischen Materials
EP2721170A2 (de) 2011-06-17 2014-04-23 Life Technologies Corporation Zusammensetzungen und verfahren für den nachweis von cronobacter spp. und cronobacter-spezies und stämmen
CA3113828A1 (en) 2011-07-15 2013-01-24 Gen-Probe Incorporated Compositions and method for detecting human parvovirus nucleic acid and for detecting hepatitis a virus nucleic acids in single-plex or multiplex assays
US8778843B1 (en) 2011-08-03 2014-07-15 Fry Laboratories, L.L.C. Semi-pan-protozoal by quantitative PCR
WO2013029021A1 (en) 2011-08-24 2013-02-28 Life Technologies Corporation Compositions and methods for detection of multiple microorganisms
EP4219741A3 (de) 2011-09-06 2023-08-23 Gen-Probe Incorporated Geschlossene nukleinsäurestrukturen
EP2753714B1 (de) 2011-09-06 2017-04-12 Gen-Probe Incorporated Zirkularisierte schablonen zur sequenzierung
EP3255155B1 (de) 2011-09-08 2019-04-24 Gen-Probe Incorporated Zusammensetzungen und verfahren zum nachweis von bv-assoziierter bakterieller nukleinsäure
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
US8380541B1 (en) 2011-09-25 2013-02-19 Theranos, Inc. Systems and methods for collecting and transmitting assay results
US9664702B2 (en) 2011-09-25 2017-05-30 Theranos, Inc. Fluid handling apparatus and configurations
US8840838B2 (en) 2011-09-25 2014-09-23 Theranos, Inc. Centrifuge configurations
US9619627B2 (en) 2011-09-25 2017-04-11 Theranos, Inc. Systems and methods for collecting and transmitting assay results
US9268915B2 (en) 2011-09-25 2016-02-23 Theranos, Inc. Systems and methods for diagnosis or treatment
US8475739B2 (en) 2011-09-25 2013-07-02 Theranos, Inc. Systems and methods for fluid handling
US20140170735A1 (en) 2011-09-25 2014-06-19 Elizabeth A. Holmes Systems and methods for multi-analysis
US9632102B2 (en) 2011-09-25 2017-04-25 Theranos, Inc. Systems and methods for multi-purpose analysis
US8435738B2 (en) 2011-09-25 2013-05-07 Theranos, Inc. Systems and methods for multi-analysis
US9175337B2 (en) 2011-09-21 2015-11-03 Gen-Probe Incorporated Methods for amplifying nucleic acid using tag-mediated displacement
US9810704B2 (en) 2013-02-18 2017-11-07 Theranos, Inc. Systems and methods for multi-analysis
EP3865875A1 (de) 2011-09-25 2021-08-18 Labrador Diagnostics LLC Systeme und verfahren für mehrfachanalyse
US10012664B2 (en) 2011-09-25 2018-07-03 Theranos Ip Company, Llc Systems and methods for fluid and component handling
US9250229B2 (en) 2011-09-25 2016-02-02 Theranos, Inc. Systems and methods for multi-analysis
WO2013045505A1 (en) 2011-09-28 2013-04-04 Novartis Ag Biomarkers for raas combination therapy
SMT202200229T1 (it) 2011-10-03 2022-07-21 Modernatx Inc Nucleosidi, nucleotidi e acidi nucleici modificati e loro usi
US9416153B2 (en) 2011-10-11 2016-08-16 Enzo Life Sciences, Inc. Fluorescent dyes
SG11201401628WA (en) 2011-10-19 2014-05-29 Nugen Technologies Inc Compositions and methods for directional nucleic acid amplification and sequencing
WO2013067413A1 (en) 2011-11-04 2013-05-10 Gen-Probe Incorporated Molecular assay reagents and methods
AU2012330817A1 (en) 2011-11-04 2014-05-22 Oslo Universitetssykehus Hf Methods and biomarkers for analysis of colorectal cancer
CN104053785A (zh) 2011-11-14 2014-09-17 综合医院公司 为患有抑郁症的受试者选择治疗方案的测定法和方法
DE102011120550B4 (de) 2011-12-05 2013-11-07 Gen-Probe Prodesse, Inc. Zusammensetzungen, Verfahren und Kits zur Detektion von Adenovirusnukleinsäuren
US10513737B2 (en) 2011-12-13 2019-12-24 Decipher Biosciences, Inc. Cancer diagnostics using non-coding transcripts
RU2649364C2 (ru) 2011-12-16 2018-04-02 Модерна Терапьютикс, Инк. Составы на основе модифицированного нуклеозида, нуклеотида и нуклеиновой кислоты
WO2013093629A2 (en) 2011-12-20 2013-06-27 Netherlands Cancer Institute Modular vaccines, methods and compositions related thereto
WO2013096460A1 (en) 2011-12-20 2013-06-27 The Regents Of The University Of Michigan Pseudogenes and uses thereof
WO2013096799A1 (en) 2011-12-22 2013-06-27 Ibis Biosciences, Inc. Systems and methods for isolating nucleic acids from cellular samples
US9803188B2 (en) 2011-12-22 2017-10-31 Ibis Biosciences, Inc. Systems and methods for isolating nucleic acids
CA2858284A1 (en) 2011-12-23 2013-06-27 Biomerieux Detection of meca variant strains of methicillin-resistant staphylococcus aureus
US9970061B2 (en) 2011-12-27 2018-05-15 Ibis Biosciences, Inc. Bioagent detection oligonucleotides
CA2860594A1 (en) 2012-01-09 2013-07-18 Oslo Universitetssykehus Hf Methods and biomarkers for analysis of colorectal cancer
GB2513793B (en) 2012-01-26 2016-11-02 Nugen Tech Inc Compositions and methods for targeted nucleic acid sequence enrichment and high efficiency library generation
JP6170077B2 (ja) 2012-02-16 2017-07-26 エータイアー ファーマ， インコーポレイテッド 自己免疫および炎症疾患を処置するためのヒスチジルｔＲＮＡ合成酵素
WO2013124738A2 (en) 2012-02-21 2013-08-29 Oslo Universitetssykehus Hf Methods and biomarkers for detection and prognosis of cervical cancer
US11098375B2 (en) 2012-02-24 2021-08-24 Gen-Probe Prodesse, Inc. Detection of Shiga toxin genes in bacteria
US20150111758A1 (en) 2012-03-06 2015-04-23 Oslo Universitetssykehus Hf Gene signatures associated with efficacy of postmastectomy radiotherapy in breast cancer
CA2869033C (en) 2012-03-29 2021-06-01 Becton, Dickinson And Company Nucleic acids for nucleic acid amplification
ES2845560T3 (es) 2012-03-29 2021-07-27 Novartis Ag Diagnóstico farmacéutico
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
WO2013151647A1 (en) 2012-04-02 2013-10-10 Life Technologies Corporation Compositions and methods for detection of mycobacterium avium paratuberculosis
AU2013243954A1 (en) 2012-04-02 2014-10-30 Moderna Therapeutics, Inc. Modified polynucleotides for the production of cosmetic proteins and peptides
US10501512B2 (en) 2012-04-02 2019-12-10 Modernatx, Inc. Modified polynucleotides
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
WO2013152114A1 (en) 2012-04-03 2013-10-10 The Regents Of The University Of Michigan Biomarker associated with irritable bowel syndrome and crohn's disease
EP2836846B1 (de) 2012-04-13 2024-04-24 Becton, Dickinson and Company Reflexprüfung von proben unter verwendung von restmaterialien aus einem vorhergehenden test
AU2013205110B2 (en) 2012-04-24 2016-10-13 Gen-Probe Incorporated Compositions, Methods and Kits to Detect Herpes Simplex Virus Nucleic Acids
AU2013205064B2 (en) 2012-06-04 2015-07-30 Gen-Probe Incorporated Compositions and Methods for Amplifying and Characterizing HCV Nucleic Acid
US9012022B2 (en) 2012-06-08 2015-04-21 Illumina, Inc. Polymer coatings
US8895249B2 (en) 2012-06-15 2014-11-25 Illumina, Inc. Kinetic exclusion amplification of nucleic acid libraries
GB2518078B (en) 2012-06-18 2015-04-29 Nugen Technologies Inc Compositions and methods for negative selection of non-desired nucleic acid sequences
US20140005061A1 (en) 2012-06-29 2014-01-02 Life Technologies Corporation Compositions and methods for detection of multiple microorganisms
WO2014005076A2 (en) 2012-06-29 2014-01-03 The Regents Of The University Of Michigan Methods and biomarkers for detection of kidney disorders
US9834823B2 (en) 2012-07-02 2017-12-05 The Translational Genomics Research Institute Primers, assays and methods for detecting an E. coli subtype
US20150011396A1 (en) 2012-07-09 2015-01-08 Benjamin G. Schroeder Methods for creating directional bisulfite-converted nucleic acid libraries for next generation sequencing
AU2013205087B2 (en) 2012-07-13 2016-03-03 Gen-Probe Incorporated Method for detecting a minority genotype
WO2014015217A1 (en) 2012-07-19 2014-01-23 Vertex Pharmaceuticals Incorporated Biomarkers for hcv infected patients
EP4071253A1 (de) 2012-07-26 2022-10-12 Illumina, Inc. Zusammensetzungen und verfahren zur amplifikation von nukleinsäuren
EP2877952B1 (de) 2012-07-27 2023-04-12 Gen-Probe Incorporated Dual-referenzkalibrierverfahren und system zum quantifizieren von polynukleotiden
AU2013202793B2 (en) 2012-07-31 2014-09-18 Gen-Probe Incorporated System, method and apparatus for automated incubation
EP4219765B1 (de) 2012-08-16 2024-12-18 Veracyte SD, Inc. Prostatakrebsprognose unter verwendung von biomarkern
CN104755630B (zh) 2012-08-30 2019-01-11 简·探针公司 多阶段核酸扩增
BR112015005429A2 (pt) 2012-09-11 2017-07-04 Theranos Inc sistemas de gestão de informação e métodos usando uma assinatura biológica
SG11201502618PA (en) 2012-10-04 2015-05-28 Univ Leland Stanford Junior Methods and reagents for detection, quantitation, and serotyping of dengue viruses
AU2013205122B2 (en) 2012-10-11 2016-11-10 Gen-Probe Incorporated Compositions and Methods for Detecting Human Papillomavirus Nucleic Acid
EP3901280B1 (de) 2012-10-17 2025-03-12 10x Genomics Sweden AB Verfahren und produkt zur optimierung einer lokalisierten oder räumlichen detektion einer genexpression in einer gewebeprobe
US20160046997A1 (en) 2012-10-18 2016-02-18 Oslo Universitetssykehus Hf Biomarkers for cervical cancer
US9181583B2 (en) 2012-10-23 2015-11-10 Illumina, Inc. HLA typing using selective amplification and sequencing
HRP20220607T1 (hr) 2012-11-26 2022-06-24 Modernatx, Inc. Terminalno modificirana rna
BR112015012239B1 (pt) 2012-11-27 2022-07-19 Pontificia Universidad Católica De Chile Método in vitro de diagnóstico de câncer de tireoide
US9890414B2 (en) 2012-11-28 2018-02-13 Abwiz Bio, Inc Preparation of gene-specific templates for the use in single primer amplification
AU2013205090B2 (en) 2012-12-07 2016-07-28 Gen-Probe Incorporated Compositions and Methods for Detecting Gastrointestinal Pathogen Nucleic Acid
JP6498125B2 (ja) 2012-12-21 2019-04-10 マイクロニクス， インコーポレイテッド 流体回路および関連する製造方法
CN107824233B (zh) 2012-12-21 2020-06-30 珀金埃尔默健康科学有限公司 用于微流体用途的低弹性膜
WO2014100725A1 (en) 2012-12-21 2014-06-26 Micronics, Inc. Portable fluorescence detection system and microassay cartridge
US9683230B2 (en) 2013-01-09 2017-06-20 Illumina Cambridge Limited Sample preparation on a solid support
JP2016509480A (ja) 2013-01-24 2016-03-31 カリフォルニア インスティチュート オブ テクノロジー 発色団に基づく特徴づけおよび検出方法
US10077475B2 (en) 2013-01-24 2018-09-18 California Institute Of Technology FRET-based analytes detection and related methods and systems
CN105164508B (zh) 2013-02-18 2019-04-02 赛拉诺斯知识产权有限责任公司 用于采集和传输测定结果的系统和方法
US9512422B2 (en) 2013-02-26 2016-12-06 Illumina, Inc. Gel patterned surfaces
US9914979B2 (en) 2013-03-04 2018-03-13 Fry Laboratories, LLC Method and kit for characterizing microorganisms
ES2887177T3 (es) 2013-03-13 2021-12-22 Illumina Inc Método de preparación de una biblioteca de secuenciación de ácidos nucleicos
PL2969479T3 (pl) 2013-03-13 2021-12-27 Illumina, Inc. Wielowarstwowe urządzenia płynowe i sposoby ich wytwarzania
US10640808B2 (en) 2013-03-13 2020-05-05 Abbott Molecular Inc. Systems and methods for isolating nucleic acids
AU2013202805B2 (en) 2013-03-14 2015-07-16 Gen-Probe Incorporated System and method for extending the capabilities of a diagnostic analyzer
EP2971171A4 (de) 2013-03-14 2016-11-02 Abbott Molecular Inc Multiplex-methylierungs-spezifische verstärkersysteme und -verfahren
EP2971175B1 (de) 2013-03-14 2019-04-17 Abbott Molecular Inc. Fehlerminimierung mittels uracil-dna-n-glycosylase
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
WO2014150910A1 (en) 2013-03-15 2014-09-25 Ibis Biosciences, Inc. Dna sequences to assess contamination in dna sequencing
US9976175B2 (en) 2013-03-15 2018-05-22 Gen-Probe Incorporated Calibration method, apparatus and computer program product
US9255265B2 (en) 2013-03-15 2016-02-09 Illumina, Inc. Methods for producing stranded cDNA libraries
US11976329B2 (en) 2013-03-15 2024-05-07 Veracyte, Inc. Methods and systems for detecting usual interstitial pneumonia
US9816088B2 (en) 2013-03-15 2017-11-14 Abvitro Llc Single cell bar-coding for antibody discovery
BR112015022470B1 (pt) 2013-03-15 2021-08-24 Becton, Dickinson And Company Sonda ou iniciador de oligonucleotídeo, método para determinar presença da sequência do gene de proteína externa principal (opca) de neisseria gonorrhoeae e composições para detecção de neisseria gonorrhoeae
EP2971130A4 (de) 2013-03-15 2016-10-05 Nugen Technologies Inc Sequentielle sequenzierung
WO2014151511A2 (en) 2013-03-15 2014-09-25 Abbott Molecular Inc. Systems and methods for detection of genomic copy number changes
KR101403507B1 (ko) 2013-03-21 2014-06-09 주식회사 현일바이오 결핵균 및 비결핵 마이코박테리아의 선택적 검출 방법, 그리고 이를 이용한 키트
US9340817B2 (en) 2013-03-27 2016-05-17 Sample6 Technologies, Inc. Methods of making recombinant phage, compositions and articles of manufacture of same for bacterial detection
KR101507505B1 (ko) 2013-04-18 2015-04-07 사회복지법인 삼성생명공익재단 제 1 형 근긴장성 이영양증의 진단 방법
EP2992331A4 (de) 2013-04-30 2017-03-29 Université de Montréal Neuartige biomarker für akute myeloische leukämie
US9365581B2 (en) 2013-05-02 2016-06-14 The Regents Of The University Of Michigan Deuterated amlexanox
JP6472788B2 (ja) 2013-05-07 2019-02-20 マイクロニクス， インコーポレイテッド 粘土鉱物およびアルカリ性溶液を使用して核酸含有試料を調製するための方法
CA2911308C (en) 2013-05-07 2021-10-19 Micronics, Inc. Device for preparation and analysis of nucleic acids
EP2994750B1 (de) 2013-05-07 2020-08-12 PerkinElmer Health Sciences, Inc. Mikrofluidische vorrichtungen und verfahren zur durchführung von serumtrennung und blutkreuzproben
WO2014183023A1 (en) 2013-05-09 2014-11-13 Trustees Of Boston University Using plexin-a4 as a biomarker and therapeutic target for alzheimer's disease
US10072300B2 (en) 2013-05-21 2018-09-11 Biomerieux Kit for the prognosis of colorectal cancer
EP3004433B1 (de) 2013-05-30 2018-09-05 The Regents of The University of California Im wesentlichen gleichmässige amplifizierung von genomen
US9828625B2 (en) 2013-06-19 2017-11-28 Phage Diagnostics, Inc. Phage-based bacterial detection assay
CN105473744B (zh) 2013-06-25 2020-06-19 普罗格诺西斯生物科学公司 采用微流控装置的空间编码生物分析
TR201816438T4 (tr) 2013-07-01 2018-11-21 Illumina Inc Katalizörsüz yüzey işlevselleştirme ve polimer aşılama.
JP2016525359A (ja) 2013-07-25 2016-08-25 ディーシーエイチ モレキュラー ダイアグノスティクス， インコーポレイテッド 細菌汚染を検出するための方法および組成物
WO2015018943A2 (en) 2013-08-08 2015-02-12 Institut Pasteur Correlation of disease activity with clonal expansions of human papillomavirus 16-specific cd8+ t-cells in patients with severe erosive oral lichen planus
WO2015023892A1 (en) 2013-08-14 2015-02-19 Gen-Probe Incorporated Compositions and methods for detecting hev nucleic acid
EP3480321B8 (de) 2013-08-28 2021-03-10 Becton, Dickinson and Company Massiv parallele einzelzellanalyse
US11545241B1 (en) 2013-09-07 2023-01-03 Labrador Diagnostics Llc Systems and methods for analyte testing and data management
BR112016007255A2 (pt) 2013-10-03 2017-09-12 Moderna Therapeutics Inc polinucleotídeos que codificam receptor de lipoproteína de baixa densidade
US9546399B2 (en) 2013-11-13 2017-01-17 Nugen Technologies, Inc. Compositions and methods for identification of a duplicate sequencing read
US10900093B2 (en) 2013-11-15 2021-01-26 Institut Pasteur Molecular marker of plasmodium falciparum artemisinin resistance
WO2015088913A1 (en) 2013-12-09 2015-06-18 Illumina, Inc. Methods and compositions for targeted nucleic acid sequencing
US11859246B2 (en) 2013-12-11 2024-01-02 Accuragen Holdings Limited Methods and compositions for enrichment of amplification products
US11286519B2 (en) 2013-12-11 2022-03-29 Accuragen Holdings Limited Methods and compositions for enrichment of amplification products
US10767222B2 (en) 2013-12-11 2020-09-08 Accuragen Holdings Limited Compositions and methods for detecting rare sequence variants
US9909181B2 (en) 2013-12-13 2018-03-06 Northwestern University Biomarkers for post-traumatic stress states
EP3083994B1 (de) 2013-12-20 2021-08-18 Illumina, Inc. Konservierung von genom-verbindungsinformationen in fragmentierten genomischen dna-proben
US9677132B2 (en) 2014-01-16 2017-06-13 Illumina, Inc. Polynucleotide modification on solid support
CA2936751C (en) 2014-01-16 2022-03-29 Illumina, Inc. Amplicon preparation and sequencing on solid supports
US9745614B2 (en) 2014-02-28 2017-08-29 Nugen Technologies, Inc. Reduced representation bisulfite sequencing with diversity adaptors
WO2015188178A1 (en) 2014-06-06 2015-12-10 The Regents Of The University Of Michigan Compositions and methods for characterizing and diagnosing periodontal disease
US20150353989A1 (en) 2014-06-09 2015-12-10 Illumina Cambridge Limited Sample preparation for nucleic acid amplification
GB201410420D0 (en) 2014-06-11 2014-07-23 Illumina Cambridge Ltd Methods for estimating cluster numbers
SG11201610357UA (en) 2014-06-13 2017-01-27 Illumina Cambridge Ltd Methods and compositions for preparing sequencing libraries
ES2713153T3 (es) 2014-06-30 2019-05-20 Illumina Inc Métodos y composiciones que utilizan la transposición unilateral
US12297505B2 (en) 2014-07-14 2025-05-13 Veracyte, Inc. Algorithms for disease diagnostics
EP3169793B1 (de) 2014-07-16 2022-07-06 Tangen Biosciences Inc. Isothermische verfahren zur amplifizierung von nukleinsäureproben
EP3183577B1 (de) 2014-08-21 2020-08-19 Illumina Cambridge Limited Reversible oberflächenfunktionalisierung
WO2016040602A1 (en) 2014-09-11 2016-03-17 Epicentre Technologies Corporation Reduced representation bisulfite sequencing using uracil n-glycosylase (ung) and endonuclease iv
CN107002076B (zh) 2014-09-15 2021-11-23 阿布维特罗有限责任公司 高通量核苷酸文库测序
US11873480B2 (en) 2014-10-17 2024-01-16 Illumina Cambridge Limited Contiguity preserving transposition
ES2905706T3 (es) 2014-10-31 2022-04-11 Illumina Cambridge Ltd Polímeros y recubrimientos de copolímeros de ADN
EP3215260B1 (de) 2014-11-03 2020-01-15 Tangen Biosciences Inc. Vorrichtung und verfahren für zellen-, sporen- oder viruserfassung und unterbrechung
GB201419731D0 (en) 2014-11-05 2014-12-17 Illumina Cambridge Ltd Sequencing from multiple primers to increase data rate and density
EP3770274A1 (de) 2014-11-05 2021-01-27 Veracyte, Inc. Systeme und verfahren zur diagnose von idiopathischer pulmonaler fibrose auf transbronchialen biopsien mit maschinellem lernen und hochdimensionalen transkriptionsdaten
JP2017533733A (ja) 2014-11-11 2017-11-16 アボツト・モレキユラー・インコーポレイテツド ハイブリダイゼーションプローブおよび方法
US10865433B2 (en) 2015-01-09 2020-12-15 Gen-Probe Incorporated Reaction mixtures for diagnosing bacterial vaginosis
KR101718800B1 (ko) 2015-01-21 2017-03-24 주식회사 디알나노 약물 및 ｓｉＲＮＡ의 공동―운반용 나노복합체 및 이의 용도
WO2016118766A2 (en) 2015-01-21 2016-07-28 T2 Biosystems, Inc. Nmr methods and systems for the rapid detection of tick-borne pathogens
US10208339B2 (en) 2015-02-19 2019-02-19 Takara Bio Usa, Inc. Systems and methods for whole genome amplification
EP3259602B9 (de) 2015-02-20 2021-05-19 Takara Bio USA, Inc. Verfahren zur schnellen präzisen abgabe, visualisierung und analyse von einzelzellen
WO2016149357A1 (en) 2015-03-16 2016-09-22 Gen-Probe Incorporated Methods and compositions for detecting bacterial nucleic acid and diagnosing bacterial vaginosis
US9708647B2 (en) 2015-03-23 2017-07-18 Insilixa, Inc. Multiplexed analysis of nucleic acid hybridization thermodynamics using integrated arrays
ES2984193T3 (es) 2015-03-31 2024-10-29 Illumina Cambridge Ltd Concatemerización de moldes en la superficie
FI3901281T3 (fi) 2015-04-10 2023-01-31 Biologisten näytteiden spatiaalisesti eroteltu moninkertainen nukleiinihappoanalyysi
US11035849B2 (en) 2015-04-13 2021-06-15 The Translational Genomics Research Institute Predicting the occurrence of metastatic cancer using epigenomic biomarkers and non-invasive methodologies
WO2016168755A1 (en) 2015-04-17 2016-10-20 Distributed Bio, Inc. Method for mass humanization of non-human antibodies
CA2982467C (en) 2015-04-24 2024-02-13 Becton, Dickinson And Company Multiplex detection of vulvovaginal candidiasis, trichomoniasis and bacterial vaginosis
ES2942572T3 (es) 2015-05-11 2023-06-02 Illumina Inc Plataforma para el descubrimiento y análisis de agentes terapéuticos
US11015217B2 (en) 2015-05-29 2021-05-25 Roche Molecular Systems, Inc. Method of inactivating microbes by citraconic anhydride
EP3303548A4 (de) 2015-06-05 2019-01-02 Miroculus Inc. Verdampfungsverwaltung in digitalen mikrofluidischen vorrichtungen
WO2016197103A1 (en) 2015-06-05 2016-12-08 Miroculus Inc. Air-matrix digital microfluidics apparatuses and methods for limiting evaporation and surface fouling
CN115015552A (zh) 2015-06-19 2022-09-06 赛拉预测公司 用于预测早产的生物标志物对
CN115261468A (zh) 2015-07-06 2022-11-01 伊卢米纳剑桥有限公司 用于核酸扩增的样品制备
HK1253950A1 (zh) 2015-07-07 2019-07-05 Illumina, Inc. 经由纳米压印的选择性表面图案化
CN107835857A (zh) 2015-07-17 2018-03-23 亿明达股份有限公司 用于测序应用的聚合物片层
EP3124619B1 (de) 2015-07-31 2019-03-06 Menicon Co., Ltd Reagenzien, verfahren und kit zur glaukomdiagnose über hunderassen hinweg und innerhalb von hunderassen
US9789087B2 (en) 2015-08-03 2017-10-17 Thomas Jefferson University PAR4 inhibitor therapy for patients with PAR4 polymorphism
HK1253910A1 (zh) 2015-09-02 2019-07-05 伊卢米纳剑桥有限公司 改善流控系统中的液滴操作的系统和方法
US9499861B1 (en) 2015-09-10 2016-11-22 Insilixa, Inc. Methods and systems for multiplex quantitative nucleic acid amplification
HK1259101A1 (zh) 2015-10-09 2019-11-22 Accuragen Holdings Limited 用於富集扩增产物的方法及组合物
KR101651817B1 (ko) 2015-10-28 2016-08-29 대한민국 Ngs 라이브러리 제작용 프라이머 세트 및 이를 이용한 ngs 라이브러리 제작방법 및 키트
WO2017096322A1 (en) 2015-12-03 2017-06-08 Accuragen Holdings Limited Methods and compositions for forming ligation products
EP3400309B1 (de) 2016-01-04 2025-03-19 Gen-Probe Incorporated Verfahren und zusammensetzungen zum nachweis von candida-spezies
CA3011991A1 (en) 2016-01-21 2017-07-27 T2 Biosystems, Inc. Rapid antimicrobial susceptibility testing using high-sensitivity direct detection methods
WO2017132538A1 (en) 2016-01-29 2017-08-03 The Regents Of The University Of Michigan Amlexanox analogs
WO2017155858A1 (en) 2016-03-07 2017-09-14 Insilixa, Inc. Nucleic acid sequence identification using solid-phase cyclic single base extension
DK3377226T3 (da) 2016-03-28 2021-04-26 Illumina Inc Mikrorækker i flere niveauer
US10765724B2 (en) 2016-03-29 2020-09-08 Janssen Biotech, Inc. Method of treating psoriasis with increased interval dosing of anti-IL12/23 antibody
AU2017250205A1 (en) 2016-04-14 2018-11-22 T2 Biosystems, Inc. Methods and systems for amplification in complex samples
CA3024630A1 (en) 2016-05-16 2017-11-23 Accuragen Holdings Limited Method of improved sequencing by strand identification
AU2017267653B2 (en) 2016-05-18 2021-05-13 Illumina, Inc. Self assembled patterning using patterned Hydrophobic surfaces
EP3469103B1 (de) 2016-06-10 2021-10-06 Gen-Probe Incorporated Zusammensetzungen und verfahren für den nachweis von zikavirus-nukleinsäure
CN109937364B (zh) 2016-06-27 2022-12-02 朱诺治疗学股份有限公司 Mhc-e限制性表位、结合分子以及相关方法和用途
CN110291402B (zh) 2016-06-27 2023-09-01 朱诺治疗学股份有限公司 鉴定肽表位的方法、结合此类表位的分子和相关用途
US11091795B2 (en) 2016-07-11 2021-08-17 Arizona Board Of Regents On Behalf Of The University Of Arizona Compositions and methods for diagnosing and treating arrhythmias
BR112019000693A2 (pt) 2016-07-15 2019-04-24 Poseida Therapeutics, Inc. composições de muc1- car e métodos para uso
US20190177421A1 (en) 2016-07-15 2019-06-13 Poseida Therapeutics, Inc. Chimeric antigen receptors and methods for use
EP3487616B1 (de) 2016-07-21 2023-08-09 Takara Bio USA, Inc. Multi-z-bildgebung von wells von multi-well-geräten und flüssigkeitsabgabe in die wells
US11535883B2 (en) 2016-07-22 2022-12-27 Illumina, Inc. Single cell whole genome libraries and combinatorial indexing methods of making thereof
US12168805B2 (en) 2016-08-10 2024-12-17 Institut Pasteur Methods and reagents for detecting piperaquine-resistant plasmodium falciparum malaria
CN109844133A (zh) 2016-08-15 2019-06-04 安可济控股有限公司 检测罕见序列变体的组合物和方法
CN109715781A (zh) 2016-08-22 2019-05-03 米罗库鲁斯公司 用于数字微流控设备中的并行液滴控制的反馈系统
US11414708B2 (en) 2016-08-24 2022-08-16 Decipher Biosciences, Inc. Use of genomic signatures to predict responsiveness of patients with prostate cancer to post-operative radiation therapy
MX2019003703A (es) 2016-09-30 2020-08-13 Janssen Biotech Inc Método seguro y eficaz para tratar la psoriasis con el anticuerpo específico anti-il23.
CN110736695A (zh) 2016-09-30 2020-01-31 多伦多大学管理委员会 用于鉴定和靶向异质群体中的个体细胞以选择性提取细胞内容物的系统
AU2017339511B2 (en) 2016-10-06 2021-12-02 Poseida Therapeutics, Inc. Inducible caspases and methods for use
US10422012B2 (en) 2016-10-10 2019-09-24 Roche Molecular Systems, Inc. Devices comprising bacteriophage PHI6 internal control compositions
CA3040907A1 (en) 2016-10-19 2018-04-26 Gen-Probe Incorporated Compositions and methods for detecting or quantifying hepatitis c virus
US11031099B2 (en) 2016-11-09 2021-06-08 Roche Molecular Systems, Inc. Detection of sequence variants
JP7645607B2 (ja) 2016-11-16 2025-03-14 ヤンセン バイオテツク，インコーポレーテツド 抗ｉｌ２３特異的抗体で乾癬を治療する方法
CN110088302B (zh) 2016-11-21 2025-02-25 简·探针公司 用于检测或定量乙型肝炎病毒的组合物和方法
JP2020515815A (ja) 2016-12-28 2020-05-28 ミロキュラス インコーポレイテッド デジタルマイクロ流体デバイスおよび方法
US10793901B2 (en) 2016-12-28 2020-10-06 Roche Molecular Systems, Inc. Reversibly protected nucleotide reagents with high thermal stability
GB201704754D0 (en) 2017-01-05 2017-05-10 Illumina Inc Kinetic exclusion amplification of nucleic acid libraries
WO2018127786A1 (en) 2017-01-06 2018-07-12 Oslo Universitetssykehus Hf Compositions and methods for determining a treatment course of action
KR101936799B1 (ko) 2017-01-09 2019-01-11 주식회사 엠이티라이프사이언스 구강전암의 치료용 약학 조성물 및 구강전암 또는 구강암의 예측 또는 진단 방법
US11208697B2 (en) 2017-01-20 2021-12-28 Decipher Biosciences, Inc. Molecular subtyping, prognosis, and treatment of bladder cancer
EP3573658A4 (de) 2017-01-30 2021-07-21 Janssen Biotech, Inc. Anti-tnf-antikörper, zusammensetzungen und verfahren zur behandlung von aktiver psoriatischer arthritis
CN110418652A (zh) 2017-02-07 2019-11-05 詹森生物科技公司 用于治疗活动性强直性脊柱炎的抗tnf抗体、组合物和方法
AU2018230784A1 (en) 2017-03-09 2019-10-10 Decipher Biosciences, Inc. Subtyping prostate cancer to predict response to hormone therapy
CN117959418A (zh) 2017-03-13 2024-05-03 波赛达治疗公司 用于选择性消除和替换造血干细胞的组合物和方法
CN110573254B (zh) 2017-03-24 2022-12-02 简·探针公司 盖组件和相关的使用方法
EP4212634A1 (de) 2017-03-24 2023-07-19 Gen-Probe Incorporated Zusammensetzungen und verfahren zum nachweis von flu b in proben
AU2018237578B2 (en) 2017-03-24 2024-03-07 Gen-Probe Incorporated Compositions and methods for detecting or quantifying Parainfluenza virus
WO2018187013A1 (en) 2017-04-04 2018-10-11 Omniome, Inc. Fluidic apparatus and methods useful for chemical and biological reactions
WO2018187476A1 (en) 2017-04-04 2018-10-11 Miroculus Inc. Digital microfluidic apparatuses and methods for manipulating and processing encapsulated droplets
US12492430B2 (en) 2017-04-11 2025-12-09 Tecan Genomics, Inc. Library quantitation and qualification
EP3615671B1 (de) 2017-04-23 2021-07-21 Illumina Cambridge Limited Zusammensetzungen und verfahren zur verbesserung der probenidentifikation in indizierten nukleinsäurebibliotheken
WO2018200386A1 (en) 2017-04-23 2018-11-01 Illumina, Inc. Compositions and methods for improving sample identification in indexed nucleic acid libraries
DK3615690T3 (da) 2017-04-23 2021-11-15 Illumina Cambridge Ltd Sammensætninger og fremgangsmåder til forbedring af prøveidentificering i indekserede nukleinsyrebiblioteker
WO2018202864A1 (fr) 2017-05-05 2018-11-08 bioMérieux Procédé de détection d'une réponse cellulaire immune
WO2018205035A1 (en) 2017-05-12 2018-11-15 Genomedx Biosciences, Inc Genetic signatures to predict prostate cancer metastasis and identify tumor agressiveness
CA3064205A1 (en) 2017-05-26 2018-11-29 Abvitro Llc High-throughput polynucleotide library sequencing and transcriptome analysis
US10995104B2 (en) 2017-05-30 2021-05-04 Roche Molecular System, Inc. Catalysts for reversing formaldehyde adducts and crosslinks
WO2018226798A1 (en) 2017-06-07 2018-12-13 Gen-Probe Incorporated Detecting babesia species nucleic acid in a sample
EP4293122B1 (de) 2017-06-07 2025-02-12 Oregon Health & Science University Einzelzellen-ganzgenombibliotheken zur methylierungssequenzierung
US20180363044A1 (en) 2017-06-14 2018-12-20 Roche Molecular Systems, Inc. Compositions and methods for improving the thermal stability of nucleic acid amplification reagents
US11217329B1 (en) 2017-06-23 2022-01-04 Veracyte, Inc. Methods and systems for determining biological sample integrity
JP6997287B2 (ja) 2017-07-10 2022-02-03 ジェン－プローブ・インコーポレーテッド 試料割り当てパラメータを使用した核酸増幅のための分析システムおよび方法
CN110892258A (zh) 2017-07-24 2020-03-17 米罗库鲁斯公司 具有集成的血浆收集设备的数字微流控系统和方法
CN110785813A (zh) 2017-07-31 2020-02-11 伊鲁米那股份有限公司 具有多路生物样本聚合的测序系统
EP4289967A3 (de) 2017-08-01 2024-03-20 Illumina, Inc. Räumliche indexierung von genetischem material und bibliothekherstellung unter verwendung von hydrogel-kügelchen und durchflusszellen
EP3662084B1 (de) 2017-08-01 2024-10-30 Illumina, Inc. Hydrogelkügelchen für nukleotidsequenzierung
US12497660B2 (en) 2017-08-04 2025-12-16 Veracyte SD, Inc. Use of immune cell-specific gene expression for prognosis of prostate cancer and prediction of responsiveness to radiation therapy
WO2019032809A1 (en) 2017-08-11 2019-02-14 Gen-Probe Incorporated COMPOSITIONS AND METHODS FOR DETECTING STAPHYLOCOCCUS AUREUS
BR112020003229A8 (pt) 2017-08-15 2023-05-09 Omniome Llc Aparelho e métodos de varredura úteis para detecção de analitos químicos e biológicos
EP4530633A3 (de) 2017-08-18 2026-03-25 Sera Prognostics, Inc. Schwangerschaftstaktproteine zur vorhersage des frühstadiums und der geburtszeit
WO2019046860A1 (en) 2017-09-01 2019-03-07 Miroculus Inc. DIGITAL MICROFLUIDIC DEVICES AND METHODS OF USE
WO2019051335A1 (en) 2017-09-07 2019-03-14 Juno Therapeutics, Inc. METHODS OF IDENTIFYING CELLULAR CHARACTERISTICS RELATED TO RESPONSES ASSOCIATED WITH CELL THERAPY
AU2018329741B2 (en) 2017-09-08 2025-02-20 Poseida Therapeutics, Inc. Compositions and methods for chimeric ligand receptor (CLR)-mediated conditional gene expression
TW201922780A (zh) 2017-09-25 2019-06-16 美商健生生物科技公司 以抗ｉｌ１２／ｉｌ２３抗體治療狼瘡之安全且有效之方法
AU2018353136B2 (en) 2017-10-19 2022-05-19 Pacific Biosciences Of California, Inc. Simultaneous background reduction and complex stabilization in binding assay workflows
US11099202B2 (en) 2017-10-20 2021-08-24 Tecan Genomics, Inc. Reagent delivery system
CN117504806A (zh) 2017-10-31 2024-02-06 豪夫迈·罗氏有限公司 改进的磁性粒子及其用途
US11851679B2 (en) 2017-11-01 2023-12-26 Juno Therapeutics, Inc. Method of assessing activity of recombinant antigen receptors
CA3081343A1 (en) 2017-11-06 2019-05-09 Janssen Biotech, Inc. Safe and effective method of treating psoriatic arthritis with anti-il23 specific antibody
WO2019099629A1 (en) 2017-11-17 2019-05-23 Gen-Probe Incorporated COMPOSITIONS AND METHODS FOR DETECTING C1orf43 NUCLEIC ACID
US11078534B2 (en) 2017-11-27 2021-08-03 Roche Molecular Systems, Inc. Photocleavable nucleotide reagents with high stability
EP3724354A1 (de) 2017-12-15 2020-10-21 Gen-Probe Incorporated Zusammensetzungen und verfahren zum nachweis von toxigenem clostridium difficile
CN118878697A (zh) 2017-12-20 2024-11-01 波赛达治疗公司 Vcar组合物和使用方法
EP3746225B1 (de) 2018-01-29 2024-10-30 Gen-Probe Incorporated Analytische systeme und verfahren
EP3749781B1 (de) 2018-02-06 2024-10-02 Gen-Probe Incorporated Dunkelrote farbstoffsondenformulierungen
KR102437660B1 (ko) 2018-02-13 2022-08-29 일루미나, 인코포레이티드 하이드로겔 비드를 사용한 dna 서열분석
US20190269757A1 (en) 2018-03-05 2019-09-05 Janssen Biotech, Inc. Methods of Treating Crohn's Disease with Anti-IL23 Specific Antibody
US20210107993A1 (en) 2018-03-07 2021-04-15 Poseida Therapeutics, Inc. Cartyrin compositions and methods for use
US20190292596A1 (en) 2018-03-21 2019-09-26 Roche Molecular Systems, Inc. Modified nucleoside phosphates with high thermal stability
US11203782B2 (en) 2018-03-29 2021-12-21 Accuragen Holdings Limited Compositions and methods comprising asymmetric barcoding
KR102383799B1 (ko) 2018-04-02 2022-04-05 일루미나, 인코포레이티드 서열-기반의 유전 검사용 대조군을 제조하기 위한 조성물 및 방법
WO2019191900A1 (en) 2018-04-03 2019-10-10 Burning Rock Biotech Compositions and methods for preparing nucleic acid libraries
FR3080185A1 (fr) 2018-04-16 2019-10-18 Biomerieux Evaluation du risque de complication chez un patient suspecte d'avoir une infection ayant un score sofa inferieur a deux
AU2019255987A1 (en) 2018-04-19 2020-12-10 Pacific Biosciences Of California, Inc. Improving accuracy of base calls in nucleic acid sequencing methods
KR20240052875A (ko) 2018-04-20 2024-04-23 일루미나, 인코포레이티드 단일 세포를 캡슐화하는 방법, 캡슐화된 세포 및 이의 용도
CN111201329B (zh) 2018-05-17 2025-02-11 伊鲁米纳公司 具有减少的扩增偏倚的高通量单细胞测序
EP3796999A4 (de) 2018-05-23 2022-03-09 Miroculus Inc. Steuerung der verdampfung in digitaler mikrofluidik
CN110785167B (zh) 2018-05-25 2023-04-07 Arca生物制药有限公司 涉及布新洛尔治疗心房颤动的方法和组合物
US11384376B2 (en) 2018-05-31 2022-07-12 Roche Molecular Systems, Inc. Reagents and methods for post-synthetic modification of nucleic acids
MX2019015262A (es) 2018-06-04 2023-01-25 Illumina Inc Bibliotecas de transcriptomas de celulas individuales de alto rendimiento y metodos de fabricacion y uso.
WO2019241290A1 (en) 2018-06-12 2019-12-19 Accuragen Holdings Limited Methods and compositions for forming ligation products
CN120099195A (zh) 2018-06-13 2025-06-06 简·探针公司 用于检测b群链球菌核酸的组合物和方法
US20210317515A1 (en) 2018-07-10 2021-10-14 Gen-Probe Incorporated Methods and systems for detecting and quantifying nucleic acids
EP3824295A4 (de) 2018-07-18 2022-04-27 Janssen Biotech, Inc. Prädiktoren mit verzögerter wirkung nach behandlung mit anti-il23-spezifischem antikörper
EP3830302B1 (de) 2018-08-01 2022-10-05 Gen-Probe Incorporated Zusammensetzungen und verfahren zum nachweis von nukleinsäuren des epstein-barr-virus
AU2019319203B8 (en) 2018-08-08 2025-10-09 Gen-Probe Incorporated Compositions, methods and kits for detecting Mycoplasma genitalium
EP3841224A1 (de) 2018-08-21 2021-06-30 Gen-Probe Incorporated Zusammensetzungen und verfahren zur amplifikation, detektion oder quantifizierung von menschlichem cytomegalovirus
EP3841222A1 (de) 2018-08-24 2021-06-30 Gen-Probe Incorporated Verfahren und zusammensetzungen zum nachweis von bakterieller nukleinsäure und zur diagnose von bakterieller vaginose
US11519033B2 (en) 2018-08-28 2022-12-06 10X Genomics, Inc. Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample
CN119119296A (zh) 2018-09-05 2024-12-13 波赛达治疗公司 同种异体细胞组合物和使用方法
WO2020069085A2 (en) 2018-09-27 2020-04-02 Gen-Probe Incorporated Compositions and methods for detecting bordetella pertussis and bordetella parapertussis nucleic acid
CN113195743A (zh) 2018-10-22 2021-07-30 简·探针公司 扩增，检测或定量人类多瘤病毒bk病毒的组合物和方法
EP4656734A3 (de) 2018-10-26 2026-02-25 Illumina, Inc. Modulierung von polymerkügelchen zur dna-verarbeitung
US20240011086A1 (en) 2018-11-15 2024-01-11 Omniome, Inc. Electronic detection of nucleic acid structure
CN113395979A (zh) 2018-11-20 2021-09-14 詹森生物科技公司 用抗il-23特异性抗体治疗银屑病的安全且有效的方法
KR20210098432A (ko) 2018-11-30 2021-08-10 일루미나, 인코포레이티드 단일 검정을 이용한 다수의 분석물의 분석
GB2578528B (en) 2018-12-04 2021-02-24 Omniome Inc Mixed-phase fluids for nucleic acid sequencing and other analytical assays
EP3894592A2 (de) 2018-12-10 2021-10-20 10X Genomics, Inc. Erzeugung von räumlichen anordnungen mit gradienten
US20200197517A1 (en) 2018-12-18 2020-06-25 Janssen Biotech, Inc. Safe and Effective Method of Treating Lupus with Anti-IL12/IL23 Antibody
CN112654715B (zh) 2018-12-19 2024-12-31 亿明达股份有限公司 改进多核苷酸簇克隆性优先性的方法
WO2020132396A1 (en) 2018-12-20 2020-06-25 Poseida Therapeutics, Inc. Nanotransposon compositions and methods of use
TW202030333A (zh) 2018-12-20 2020-08-16 美商簡 探針公司 用於檢測瘧原蟲物種核酸之組成物及方法
WO2020132350A2 (en) 2018-12-20 2020-06-25 Omniome, Inc. Temperature control for analysis of nucleic acids and other analytes
US20220080425A1 (en) 2018-12-31 2022-03-17 Gen-Probe Incorporated Tray for transfering solid reagents to a multi-well cartridge
US11926867B2 (en) 2019-01-06 2024-03-12 10X Genomics, Inc. Generating capture probes for spatial analysis
US11649485B2 (en) 2019-01-06 2023-05-16 10X Genomics, Inc. Generating capture probes for spatial analysis
CN113574066A (zh) 2019-01-15 2021-10-29 詹森生物科技公司 用于治疗幼年特发性关节炎的抗tnf抗体组合物和方法
KR20210118878A (ko) 2019-01-23 2021-10-01 얀센 바이오테크 인코포레이티드 건선성 관절염의 치료 방법에 사용하기 위한 항-tnf 항체 조성물
EP3917670A4 (de) 2019-01-31 2022-11-02 Miroculus Inc. Nichtverschmutzende zusammensetzungen und verfahren zum manipulieren und verarbeiten von eingekapselten tröpfchen
CN113613787B (zh) 2019-02-20 2023-06-13 加利福尼亚太平洋生物科学股份有限公司 用于检测化学和生物分析物的扫描装置和方法
CN113766975B (zh) 2019-02-28 2023-12-29 米罗库鲁斯公司 数字微流控设备及其使用方法
EP3837365A1 (de) 2019-03-01 2021-06-23 Illumina, Inc. Einzelkern- und einzell-bibliotheken mit hohem durchsatz und verfahren zu ihrer herstellung und verwendung
KR20210141990A (ko) 2019-03-14 2021-11-23 얀센 바이오테크 인코포레이티드 항-il12/il23 항체 조성물을 생성하기 위한 제조 방법
CN113924041B (zh) 2019-03-14 2024-12-03 因斯利克萨公司 基于时间门控的荧光检测的方法和系统
EP3938390A1 (de) 2019-03-14 2022-01-19 Janssen Biotech, Inc. Herstellungsverfahren zur herstellung von anti-tnf-antikörperzusammensetzungen
JP7662529B2 (ja) 2019-03-14 2025-04-15 ヤンセン バイオテツク，インコーポレーテツド 抗ｔｎｆ抗体組成物を産生するための方法
EP3938391A1 (de) 2019-03-14 2022-01-19 Janssen Biotech, Inc. Verfahren zur herstellung von anti-tnf-antikörperzusammensetzungen
EP4389916A3 (de) 2019-03-22 2024-10-16 Gen-Probe Incorporated Zusammensetzungen und verfahren zum nachweis von gruppe-a-streptococcus
CN113646007B (zh) 2019-03-29 2024-08-23 希森美康株式会社 新人工核酸、其制造方法及用途
CN119158636A (zh) 2019-04-08 2024-12-20 米罗库鲁斯公司 多盒式数字微流控装置和使用方法
CA3137749C (en) 2019-05-03 2023-12-05 Gen-Probe Incorporated Receptacle transport system for an analytical system
US11780911B2 (en) 2019-05-23 2023-10-10 Janssen Biotech, Inc. Method of treating inflammatory bowel disease with a combination therapy of antibodies to IL-23 and TNF alpha
EP3976820A1 (de) 2019-05-30 2022-04-06 10X Genomics, Inc. Verfahren zum nachweis der räumlichen heterogenität einer biologischen probe
MX2021014882A (es) 2019-06-03 2022-03-25 Janssen Biotech Inc Anticuerpos anti-tnf, composiciones y métodos para el tratamiento de la espondilitis anquilosante activa.
CN113939531A (zh) 2019-06-03 2022-01-14 詹森生物科技公司 用于治疗银屑病关节炎的抗tnf抗体组合物和方法
KR20220016954A (ko) 2019-06-04 2022-02-10 얀센 바이오테크 인코포레이티드 항-il23 특이적 항체에 의해 건선성 관절염을 치료하는 안전하고 효과적인 방법
US11644406B2 (en) 2019-06-11 2023-05-09 Pacific Biosciences Of California, Inc. Calibrated focus sensing
EP3994284A1 (de) 2019-07-03 2022-05-11 Gen-Probe Incorporated Trichomonas vaginalis oligonukleotide zur verwendung bei der bestimmung der anwesenheit in einer probe
KR20220034716A (ko) 2019-07-12 2022-03-18 일루미나 케임브리지 리미티드 고체 지지물 상에 고정된 crispr/cas9를 사용하여 핵산 서열분석 라이브러리를 제조하기 위한 조성물 및 방법
MX2021007774A (es) 2019-07-12 2021-08-05 Illumina Cambridge Ltd Preparacion de genoteca de acido nucleico usando electroforesis.
US10656368B1 (en) 2019-07-24 2020-05-19 Omniome, Inc. Method and system for biological imaging using a wide field objective lens
US11524298B2 (en) 2019-07-25 2022-12-13 Miroculus Inc. Digital microfluidics devices and methods of use thereof
WO2021028752A1 (en) 2019-08-15 2021-02-18 Janssen Biotech, Inc. Anti-tfn antibodies for treating type i diabetes
EP4018004B1 (de) 2019-08-23 2025-06-18 Gen-Probe Incorporated Zusammensetzungen, verfahren und kits zum nachweis von treponema pallidum
EP4025593A1 (de) 2019-09-05 2022-07-13 Poseida Therapeutics, Inc. Zusammensetzungen allogener zellen und verfahren zur verwendung
CA3153514A1 (en) 2019-09-05 2021-03-11 Gen-Probe Incorporated Detection of chlamydia trachomatis nucleic acid variants
EP4028407B1 (de) 2019-09-10 2023-08-16 Pacific Biosciences of California, Inc. Reversible nukleotide änderung
EP4025711A2 (de) 2019-11-08 2022-07-13 10X Genomics, Inc. Erhöhung der spezifität einer analytbindung
WO2021091611A1 (en) 2019-11-08 2021-05-14 10X Genomics, Inc. Spatially-tagged analyte capture agents for analyte multiplexing
AU2020402029B2 (en) 2019-12-09 2022-12-15 Gen-Probe Incorporated Quantification of polynucleotide analytes from dried samples
EP4073175A1 (de) 2019-12-09 2022-10-19 F. Hoffmann-La Roche AG Dikationische fluoreszenzfarbstoffe
MX2021011847A (es) 2019-12-19 2021-11-17 Illumina Inc Genotecas de celulas unicas de alto rendimiento y metodos para elaborarlas y usarlas.
AU2020407235A1 (en) 2019-12-20 2022-07-07 Poseida Therapeutics, Inc. Anti-MUC1 compositions and methods of use
ES2946357T3 (es) 2019-12-23 2023-07-17 10X Genomics Inc Métodos para el análisis espacial usando ligación con molde de ARN
WO2021133916A1 (en) 2019-12-23 2021-07-01 Abbott Laboratories Compositions and methods for detecting picobirnavirus
WO2021133842A1 (en) 2019-12-23 2021-07-01 10X Genomics, Inc. Compositions and methods for using fixed biological samples in partition-based assays
CN115135984B (zh) 2019-12-23 2025-12-23 10X基因组学有限公司 可逆固定试剂及其使用方法
WO2021138325A1 (en) 2019-12-30 2021-07-08 Abbott Laboratories Compositions and methods for detecting bunyavirus
US12365942B2 (en) 2020-01-13 2025-07-22 10X Genomics, Inc. Methods of decreasing background on a spatial array
ES2977336T3 (es) 2020-01-16 2024-08-22 Dnae Diagnostics Ltd Composiciones, kits y métodos para aislar polinucleótidos diana
US12405264B2 (en) 2020-01-17 2025-09-02 10X Genomics, Inc. Electrophoretic system and method for analyte capture
US11702693B2 (en) 2020-01-21 2023-07-18 10X Genomics, Inc. Methods for printing cells and generating arrays of barcoded cells
US11732299B2 (en) 2020-01-21 2023-08-22 10X Genomics, Inc. Spatial assays with perturbed cells
US20210230681A1 (en) 2020-01-24 2021-07-29 10X Genomics, Inc. Methods for spatial analysis using proximity ligation
US11821035B1 (en) 2020-01-29 2023-11-21 10X Genomics, Inc. Compositions and methods of making gene expression libraries
US12076701B2 (en) 2020-01-31 2024-09-03 10X Genomics, Inc. Capturing oligonucleotides in spatial transcriptomics
US12110541B2 (en) 2020-02-03 2024-10-08 10X Genomics, Inc. Methods for preparing high-resolution spatial arrays
US11898205B2 (en) 2020-02-03 2024-02-13 10X Genomics, Inc. Increasing capture efficiency of spatial assays
CN113275053A (zh) 2020-02-03 2021-08-20 帝肯基因组学公司 试剂存储系统
CN115243792A (zh) 2020-02-04 2022-10-25 加利福尼亚太平洋生物科学股份有限公司 流通池及其制造和使用方法
US11732300B2 (en) 2020-02-05 2023-08-22 10X Genomics, Inc. Increasing efficiency of spatial analysis in a biological sample
US12129516B2 (en) 2020-02-07 2024-10-29 10X Genomics, Inc. Quantitative and automated permeabilization performance evaluation for spatial transcriptomics
US11835462B2 (en) 2020-02-11 2023-12-05 10X Genomics, Inc. Methods and compositions for partitioning a biological sample
US12281357B1 (en) 2020-02-14 2025-04-22 10X Genomics, Inc. In situ spatial barcoding
US12399123B1 (en) 2020-02-14 2025-08-26 10X Genomics, Inc. Spatial targeting of analytes
US11891654B2 (en) 2020-02-24 2024-02-06 10X Genomics, Inc. Methods of making gene expression libraries
US11926863B1 (en) 2020-02-27 2024-03-12 10X Genomics, Inc. Solid state single cell method for analyzing fixed biological cells
US11768175B1 (en) 2020-03-04 2023-09-26 10X Genomics, Inc. Electrophoretic methods for spatial analysis
AU2021230341C1 (en) 2020-03-04 2026-03-26 Gen-Probe Incorporated Compositions and methods for detecting SARS-CoV-2 nucleic acid
JP7817176B2 (ja) 2020-03-04 2026-02-18 ポセイダ セラピューティクス，インコーポレイティド 代謝性肝障害の治療のための組成物と方法
US20230121433A1 (en) 2020-03-11 2023-04-20 Poseida Therapeutics, Inc. Chimeric stimulatory receptors and methods of use in t cell activation and differentiation
EP4127220B1 (de) 2020-03-30 2024-06-05 Illumina, Inc. Verfahren und zusammensetzungen zur herstellung von nukleinsäurebibliotheken
CN115996747A (zh) 2020-04-14 2023-04-21 波赛达治疗公司 用于治疗癌症的组合物和方法
EP4549582A3 (de) 2020-04-22 2025-06-18 10x Genomics, Inc. Verfahren zur räumlichen analyse unter verwendung von gezieltem rna-abbau
EP4146273A4 (de) 2020-05-05 2024-07-31 Janssen Biotech, Inc. Verfahren zur behandlung von morbus crohn mit anti-il23-spezifischem antikörper
WO2021224873A1 (en) 2020-05-07 2021-11-11 Grifols Diagnostic Solutions Inc. Methods and compositions for detecting sars-cov-2 nucleic acid
KR20230035237A (ko) 2020-05-12 2023-03-13 일루미나, 인코포레이티드 재조합 말단 데옥시뉴클레오티딜 트랜스퍼라제를 사용하여 변형된 염기를 갖는 핵산의 생성
US12416603B2 (en) 2020-05-19 2025-09-16 10X Genomics, Inc. Electrophoresis cassettes and instrumentation
EP4153220A4 (de) 2020-05-21 2024-09-11 Janssen Biotech, Inc. Verfahren zur behandlung von entzündlicher darmerkrankung mit einer kombinationstherapie von antikörpern gegen il-23 und tnf-alpha
ES2989052T3 (es) 2020-05-22 2024-11-25 10X Genomics Inc Medición espacio-temporal simultánea de la expresión génica y la actividad celular
EP4553168A3 (de) 2020-05-22 2025-08-27 10x Genomics, Inc. Räumliche analyse zur erkennung von sequenzvarianten
WO2021242834A1 (en) 2020-05-26 2021-12-02 10X Genomics, Inc. Method for resetting an array
CN116249785A (zh) 2020-06-02 2023-06-09 10X基因组学有限公司 用于抗原-受体的空间转录组学
AU2021283174A1 (en) 2020-06-02 2023-01-05 10X Genomics, Inc. Nucleic acid library methods
US12265079B1 (en) 2020-06-02 2025-04-01 10X Genomics, Inc. Systems and methods for detecting analytes from captured single biological particles
US12031177B1 (en) 2020-06-04 2024-07-09 10X Genomics, Inc. Methods of enhancing spatial resolution of transcripts
WO2021246820A1 (ko) 2020-06-05 2021-12-09 주식회사 씨젠 호흡기 병원체 검출을 위한 검체수송 키트 및 이를 이용한 호흡기 병원체 검출방법
WO2021252499A1 (en) 2020-06-08 2021-12-16 10X Genomics, Inc. Methods of determining a surgical margin and methods of use thereof
EP4162075A4 (de) 2020-06-08 2024-06-26 The Broad Institute, Inc. Kombinatorische einzelzellindizierung von amplifizierten nukleinsäuren
WO2021252617A1 (en) 2020-06-09 2021-12-16 Illumina, Inc. Methods for increasing yield of sequencing libraries
EP4165207B1 (de) 2020-06-10 2024-09-25 10X Genomics, Inc. Verfahren zur bestimmung der position eines analyten in einer biologischen probe
WO2021252574A1 (en) 2020-06-10 2021-12-16 Sera Prognostics, Inc. Nucleic acid biomarkers for placental dysfunction
EP4164796A4 (de) 2020-06-10 2024-03-06 10x Genomics, Inc. Flüssigkeitsabgabeverfahren
US12435363B1 (en) 2020-06-10 2025-10-07 10X Genomics, Inc. Materials and methods for spatial transcriptomics
ES2994976T3 (en) 2020-06-25 2025-02-05 10X Genomics Inc Spatial analysis of dna methylation
CA3177299A1 (en) 2020-06-30 2022-01-06 Illumina Inc. Catalytically controlled sequencing by synthesis to produce scarless dna
US12209280B1 (en) 2020-07-06 2025-01-28 10X Genomics, Inc. Methods of identifying abundance and location of an analyte in a biological sample using second strand synthesis
US11981960B1 (en) 2020-07-06 2024-05-14 10X Genomics, Inc. Spatial analysis utilizing degradable hydrogels
US11761038B1 (en) 2020-07-06 2023-09-19 10X Genomics, Inc. Methods for identifying a location of an RNA in a biological sample
WO2022013745A1 (en) 2020-07-13 2022-01-20 Janssen Biotech, Inc. Safe and effective method of treating psoriatic arthritis with anti-il23 specific antibody
WO2022016153A1 (en) 2020-07-17 2022-01-20 Gen-Probe Incorporated Detection of macrolide-resistant mycoplasma genitalium
CA3190588A1 (en) 2020-08-06 2022-02-10 Illumina, Inc. Preparation of rna and dna sequencing libraries using bead-linked transposomes
US12553898B1 (en) 2020-08-10 2026-02-17 10X Genomics, Inc. Fluorescent hybridization of antibody-oligonucleotide for multiplexing and signal amplification
CA3191159A1 (en) 2020-08-18 2022-02-24 Illumina, Inc. Sequence-specific targeted transposition and selection and sorting of nucleic acids
US11981958B1 (en) 2020-08-20 2024-05-14 10X Genomics, Inc. Methods for spatial analysis using DNA capture
JP7826289B2 (ja) 2020-09-11 2026-03-09 イルミナ ケンブリッジ リミテッド ヘアピンアダプターを使用して配列決定ライブラリーから標的配列を濃縮する方法
ES2993269T3 (en) 2020-09-18 2024-12-26 10X Genomics Inc Sample handling apparatus and image registration methods
US11926822B1 (en) 2020-09-23 2024-03-12 10X Genomics, Inc. Three-dimensional spatial analysis
JP7725490B2 (ja) 2020-09-25 2025-08-19 株式会社理研ジェネシス 新規人工核酸、その製造方法及び用途
WO2022087257A2 (en) 2020-10-21 2022-04-28 Gen-Probe Incorporated Fluid container management system
WO2022087148A1 (en) 2020-10-21 2022-04-28 Poseida Therapeutics, Inc. Compositions and methods for delivery of nucleic acids
CN116507742A (zh) 2020-11-05 2023-07-28 贝克顿迪金森公司 霍乱弧菌的多重检测和分型
US20240060145A1 (en) 2020-11-05 2024-02-22 Becton, Dickinson And Company Rapid identification and typing of vibrio parahaemolyticus
CA3194255A1 (en) 2020-11-05 2022-05-12 Becton, Dickinson And Company Multiplex detection of bacterial respiratory pathogens
US11827935B1 (en) 2020-11-19 2023-11-28 10X Genomics, Inc. Methods for spatial analysis using rolling circle amplification and detection probes
EP4121555B1 (de) 2020-12-21 2026-02-25 10X Genomics, Inc. Verfahren zur erfassung von sonden und/oder barcodes
EP4288562B1 (de) 2021-02-04 2024-11-20 Illumina, Inc. Erzeugung von langem indexiertem verknüpftem lesen auf transposomgebundenen kügelchen
ES2989523T3 (es) 2021-02-19 2024-11-26 10X Genomics Inc Método de uso de un dispositivo modular de soporte para ensayos
US20240060090A1 (en) 2021-02-23 2024-02-22 Poseida Therapeutics, Inc. Genetically modified induced pluripotent stem cells and methods of use thereof
US20240189446A1 (en) 2021-02-23 2024-06-13 Poseida Therapeutics, Inc. Compositions and methods for delivery of nucleic acids
EP4301863A1 (de) 2021-03-04 2024-01-10 Poseida Therapeutics, Inc. Zusammensetzungen und verfahren zur behandlung von hämophilie
JP2024510588A (ja) 2021-03-12 2024-03-08 ヤンセン バイオテツク，インコーポレーテツド 抗ｉｌ２３特異的抗体による、ｔｎｆ療法に対する不十分な応答を有する乾癬性関節炎患者を治療する方法
BR112023018353A2 (pt) 2021-03-12 2024-02-06 Janssen Biotech Inc Método seguro e eficaz para tratamento da artrite psoriática com anticorpo específico anti-il23
ES3008686T3 (en) 2021-03-18 2025-03-24 10X Genomics Inc Multiplex capture of gene and protein expression from a biological sample
AU2022245985A1 (en) 2021-03-22 2023-09-21 Illumina Cambridge Limited Methods for improving nucleic acid cluster clonality
IL307195A (en) 2021-03-29 2023-11-01 Illumina Inc Improved methods of library preparation
JP2024513187A (ja) 2021-03-29 2024-03-22 イルミナ インコーポレイテッド ライブラリー中のｄｎａ損傷を評価し、アンプリコンサイズバイアスを正規化するための組成物及び方法
JP2024512917A (ja) 2021-03-30 2024-03-21 イルミナ インコーポレイテッド 等温相補的ｄｎａ及びライブラリ調製の改善された方法
JP2024511760A (ja) 2021-03-31 2024-03-15 イルミナ インコーポレイテッド エラー補正のための固有分子識別子を有するトランスポゾンベースの技術を使用した指向性タグメンテーション配列決定ライブラリーの調製方法
WO2022221425A1 (en) 2021-04-14 2022-10-20 10X Genomics, Inc. Methods of measuring mislocalization of an analyte
EP4320271B1 (de) 2021-05-06 2025-03-19 10X Genomics, Inc. Verfahren zur erhöhung der auflösung von räumlicher analyse
CA3218222A1 (en) 2021-05-14 2022-11-17 Gen-Probe Incorporated Compositions and methods for detecting human adenovirus nucleic acid
EP4347879B1 (de) 2021-06-03 2025-02-19 10X Genomics, Inc. Verfahren, zusammensetzungen, kits und systeme zur verbesserung der analyterfassung zur räumlichen analyse
WO2022265994A1 (en) 2021-06-15 2022-12-22 Illumina, Inc. Hydrogel-free surface functionalization for sequencing
EP4363610B1 (de) 2021-07-01 2025-08-06 Gen-Probe Incorporated Enzymformulierungen und reaktionsmischungen zur nukleinsäureamplifikation
IL309997A (en) 2021-07-09 2024-03-01 Janssen Biotech Inc Production methods for the production of anti-TNF antibody compositions
IL309996A (en) 2021-07-09 2024-03-01 Janssen Biotech Inc Production methods for the production of anti-TNF antibody compositions
JP2024527581A (ja) 2021-07-09 2024-07-25 ヤンセン バイオテツク，インコーポレーテツド 抗ｉｌ１２／ｉｌ２３抗体組成物を生産するための製造方法
CA3226451A1 (en) 2021-07-21 2023-01-26 Sam Reed Method and system comprising a cartridge for sequencing target polynucleotides
GB202110479D0 (en) 2021-07-21 2021-09-01 Dnae Diagnostics Ltd Compositions, kits and methods for sequencing target polynucleotides
GB202110485D0 (en) 2021-07-21 2021-09-01 Dnae Diagnostics Ltd Compositions, kits and methods for sequencing target polynucleotides
CN117813391A (zh) 2021-07-23 2024-04-02 因美纳有限公司 制备用于dna测序的基底表面的方法
EP4377481A1 (de) 2021-07-27 2024-06-05 Gen-Probe Incorporated Zusammensetzungen und verfahren zum nachweis von gastrointestinalen pathogenen
US12553805B2 (en) 2021-08-02 2026-02-17 10X Genomics, Inc. Methods of preserving a biological sample
WO2023021330A1 (en) 2021-08-16 2023-02-23 University Of Oslo Compositions and methods for determining a treatment course of action
WO2023034076A1 (en) 2021-08-31 2023-03-09 Illumina, Inc. Flow cell with enhanced well imaging resolution
WO2023034489A1 (en) 2021-09-01 2023-03-09 10X Genomics, Inc. Methods, compositions, and kits for blocking a capture probe on a spatial array
WO2023060089A2 (en) 2021-10-04 2023-04-13 Poseida Therapeutics, Inc. Transposases and uses thereof
KR20240095537A (ko) 2021-10-04 2024-06-25 포세이다 테라퓨틱스, 인크. 트랜스포존 조성물 및 이의 이용 방법
CA3234961A1 (en) 2021-10-20 2023-04-27 Illumina, Inc. Methods for capturing library dna for sequencing
EP4424242A4 (de) 2021-10-29 2025-10-15 Seegene Inc Probensammeltupferwerkzeug und verfahren zum nachweis von erregern respiratorischer krankheitserreger
JP2024541946A (ja) 2021-10-29 2024-11-13 ヤンセン バイオテツク，インコーポレーテツド 抗ｉｌ２３特異的抗体を用いてクローン病を治療する方法
EP4419707A1 (de) 2021-11-10 2024-08-28 10X Genomics, Inc. Verfahren, zusammensetzungen und kits zur bestimmung der position eines analyten in einer biologischen probe
AU2022388887A1 (en) 2021-11-15 2024-07-04 Janssen Biotech, Inc. Methods of treating crohn's disease with anti-il23 specific antibody
KR20240103043A (ko) 2021-11-23 2024-07-03 얀센 바이오테크 인코포레이티드 항-il23 특이적 항체로 궤양성 결장염을 치료하는 방법
CN113981041B (zh) * 2021-11-25 2024-04-30 首都医科大学附属北京安贞医院 靶向富集测序试剂及靶向富集方法
WO2023102118A2 (en) 2021-12-01 2023-06-08 10X Genomics, Inc. Methods, compositions, and systems for improved in situ detection of analytes and spatial analysis
WO2023122033A1 (en) 2021-12-20 2023-06-29 10X Genomics, Inc. Self-test for pathology/histology slide imaging device
JPWO2023127857A1 (de) 2021-12-27 2023-07-06
US11772093B2 (en) 2022-01-12 2023-10-03 Miroculus Inc. Methods of mechanical microfluidic manipulation
AU2023208743A1 (en) 2022-01-20 2024-01-04 Illumina, Inc. Methods of detecting methylcytosine and hydroxymethylcytosine by sequencing
AU2023210287A1 (en) 2022-01-21 2024-09-05 Poseida Therapeutics, Inc. Compositions and methods for delivery of nucleic acids
WO2023152568A2 (en) 2022-02-10 2023-08-17 Oslo Universitetssykehus Hf Compositions and methods for characterizing lung cancer
US20250171809A1 (en) 2022-02-23 2025-05-29 Poseida Therapeutics, Inc. Genetically modified cells and methods of use thereof
WO2023175434A1 (en) 2022-03-15 2023-09-21 Diagenode S.A. Detection of methylation status of a dna sample
CA3223722A1 (en) 2022-04-07 2023-10-12 Illumina, Inc. Altered cytidine deaminases and methods of use
CA3257687A1 (en) 2022-05-18 2023-11-23 Janssen Biotech, Inc. METHOD FOR EVALUATING AND TREATMENT OF PSORIATIC ARTHRITIS WITH AN IL23 ANTIBODY
EP4282980A1 (de) 2022-05-23 2023-11-29 Mobidiag Oy Methoden zum verstärken einer nukleinsäure
WO2024020360A1 (en) 2022-07-18 2024-01-25 Pairwise Plants Services, Inc. Mustard green plants named 'pwrg-1', 'pwrg-2,' and 'pwsgc'
KR102559124B1 (ko) 2022-08-25 2023-07-26 주식회사 엔젠바이오 Flt3 유전자 증폭용 조성물 및 이의 용도
WO2024054924A1 (en) 2022-09-08 2024-03-14 Gen-Probe Incorporated Method of detecting nucleic acid analytes using dual-specificity primers
US20250388894A1 (en) 2022-09-30 2025-12-25 Illumina, Inc. Methods of using cpg binding proteins in mapping modified cytosine nucleotides
WO2024069581A1 (en) 2022-09-30 2024-04-04 Illumina Singapore Pte. Ltd. Helicase-cytidine deaminase complexes and methods of use
WO2024073047A1 (en) 2022-09-30 2024-04-04 Illumina, Inc. Cytidine deaminases and methods of use in mapping modified cytosine nucleotides
WO2024081776A1 (en) 2022-10-13 2024-04-18 Gen-Probe Incorporated Cellularity control for nucleic acid assays
EP4482979B1 (de) 2022-11-09 2025-10-01 10X Genomics, Inc. Verfahren, zusammensetzungen und kits zur bestimmung der position mehrerer analyten in einer biologischen probe
WO2024110898A1 (en) 2022-11-22 2024-05-30 Janssen Biotech, Inc. Method of treating ulcerative colitis with anti-il23 specific antibody
WO2024129969A1 (en) 2022-12-14 2024-06-20 Illumina, Inc. Systems and methods for capture and enrichment of clustered beads on flow cell substrates
AU2023408044A1 (en) 2022-12-19 2025-07-31 Gen-Probe Incorporated Compositions and methods for detecting gastrointestinal pathogens
EP4389887A1 (de) 2022-12-21 2024-06-26 Mobidiag Oy Isolierung und lyse von zellen
EP4389911A1 (de) 2022-12-21 2024-06-26 Mobidiag Oy Verfahren und systeme zur isolierung eines analyten
WO2024155938A1 (en) 2023-01-20 2024-07-25 Poseida Therapeutics, Inc. Lipidoid compounds and related compositions and uses
EP4651943A1 (de) 2023-01-20 2025-11-26 Poseida Therapeutics, Inc. Lipidoidverbindungen und verwandte zusammensetzungen und verwendungen
WO2024161179A1 (en) 2023-01-31 2024-08-08 Mobidiag Oy Compositions and methods for detecting stx nucleic acids
CN121079404A (zh) 2023-02-21 2025-12-05 波西达治疗公司 用于基因组编辑的组合物和方法
IL322548A (en) 2023-02-21 2025-10-01 Poseida Therapeutics Inc AAV PIGGYBAC transposon polynucleotide compositions and methods of using them
CN121079405A (zh) 2023-02-21 2025-12-05 波西达治疗公司 用于基因组编辑的组合物和方法
EP4680772A1 (de) 2023-03-16 2026-01-21 Gen-Probe Incorporated Zusammensetzungen und verfahren zum nachweis von gastrointestinalen parasiten
EP4689085A1 (de) 2023-04-05 2026-02-11 Poseida Therapeutics, Inc. Chimäre transposasen und verwendungen davon
EP4689091A2 (de) 2023-04-05 2026-02-11 Poseida Therapeutics, Inc. Transposasen und verwendungen davon
EP4455304A1 (de) 2023-04-28 2024-10-30 Mobidiag Oy Kontrollen für nukleinsäureamplifikationsverfahren
EP4455303A1 (de) 2023-04-28 2024-10-30 Mobidiag Oy Kontrollen für nukleinsäureamplifikationsverfahren
EP4454758A1 (de) 2023-04-28 2024-10-30 Mobidiag Oy Kontrollen für nukleinsäureamplifikationsverfahren
EP4705516A1 (de) 2023-05-05 2026-03-11 Gen-Probe Incorporated Verfahren und system zur verbesserung der spezifität eines analytnachweises mittels nukleinsäureamplifikation in echtzeit
WO2024233804A1 (en) 2023-05-10 2024-11-14 Poseida Therapeutics, Inc. Transposases and uses thereof
FI20235652A1 (en) 2023-06-12 2024-12-13 Mobidiag Oy Methods for isolating microbial analyte
AU2024332565A1 (en) 2023-09-01 2026-03-26 Poseida Therapeutics, Inc. Lipidoid compounds and related compositions and uses
WO2025064507A1 (en) 2023-09-19 2025-03-27 Poseida Therapeutics, Inc. Compositions and methods for integration of viral vectors
WO2025072800A2 (en) 2023-09-28 2025-04-03 Illumina, Inc. Altered cytidine deaminases and methods of use
WO2025081064A2 (en) 2023-10-11 2025-04-17 Illumina, Inc. Thermophilic deaminase and methods for identifying modified cytosine
WO2025137222A1 (en) 2023-12-19 2025-06-26 Illumina, Inc. Methylation detection assay
WO2025160432A1 (en) 2024-01-26 2025-07-31 Poseida Therapeutics, Inc. Methods and compositions for enhancing in vivo persistence and potency of cell therapy
WO2025171237A1 (en) 2024-02-08 2025-08-14 Poseida Therapeutics, Inc. Lipidoid compounds and related compositions and uses
WO2025172242A1 (en) 2024-02-13 2025-08-21 bioMérieux Method of assessing the risk of death of a patient
CA3249015A1 (en) 2024-03-20 2025-10-31 Janssen Biotech, Inc. Methods of treating crohn’s disease with anti-il23 specific antibody
WO2025221789A1 (en) 2024-04-16 2025-10-23 Poseida Therapeutics, Inc. Compositions and methods for use in car/tcr cell therapies
WO2025240905A1 (en) 2024-05-17 2025-11-20 The Broad Institute, Inc. Imaging-free high-resolution spatial macromolecule abundance reconstruction
WO2025262604A1 (en) 2024-06-17 2025-12-26 Janssen Biotech, Inc. Methods of treating crohn's disease with anti-il23 specific antibody
WO2025264831A1 (en) 2024-06-18 2025-12-26 Illumina, Inc. Methods for increasing sequencing quality of gc-rich regions
WO2025264836A1 (en) 2024-06-18 2025-12-26 Illumina, Inc. Methods for increasing sequencing quality of gc-rich regions
WO2026006774A1 (en) 2024-06-28 2026-01-02 Illumina, Inc. Altered cytidine deaminases and methods of use
WO2026006314A1 (en) 2024-06-28 2026-01-02 Illumina, Inc. Tagging target regions prior to nucleotide sequencing
WO2026033466A2 (en) 2024-08-07 2026-02-12 Gen-Probe Incorporated Methods and oligonucleotide combinations for detecting the presence of monkeypox virus (mpxv) in a sample
WO2026050332A1 (en) 2024-08-29 2026-03-05 Gen-Probe Incorporated Methods and compositions for amplifying and/or detecting rotavirus nucleic acids

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1982000158A1 (en) * 1980-07-08 1982-01-21 Salk Inst For Biological Studi System for amplification of eukaryotic genes
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
DK171161B1 (da) * 1985-03-28 1996-07-08 Hoffmann La Roche Fremgangsmåde til påvisning af forekomst eller fravær af mindst én specifik nukleinsyresekvens i en prøve eller til skelnen mellem to forskellige nukleinsyresekvenser i denne prøve
SE8601784L (sv) * 1986-04-18 1987-10-19 Flensburg Carl G A Sett for ileggning av signaturer samt ileggare for utovning av settet
EP0272098A3 (de) * 1986-12-15 1990-06-06 City Of Hope National Medical Center Verfahren zur Vergrösserung und zum Nachweis von RNS-Sequenzen
IL86724A (en) * 1987-06-19 1995-01-24 Siska Diagnostics Inc Methods and kits for amplification and testing of nucleic acid sequences
WO1989001050A1 (en) * 1987-07-31 1989-02-09 The Board Of Trustees Of The Leland Stanford Junior University Selective amplification of target polynucleotide sequences
DE3726934A1 (de) * 1987-08-13 1989-02-23 Merck Patent Gmbh Verfahren zum nachweis von nukleinsaeure-sequenzen
CA1340807C (en) * 1988-02-24 1999-11-02 Lawrence T. Malek Nucleic acid amplification process
HU216105B (hu) * 1988-12-16 1999-04-28 Akzo Nobel N.V. Amplifikációs eljárás önfenntartó szekvenciareplikációs rendszerrel
IE66597B1 (en) * 1989-05-10 1996-01-24 Akzo Nv Method for the synthesis of ribonucleic acid (RNA)

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WO1991002818A1 (en) 1991-03-07
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