AR069797A1 - Anticuerpos especificos bivalentes - Google Patents

Anticuerpos especificos bivalentes

Info

Publication number
AR069797A1
AR069797A1 ARP080105518A ARP080105518A AR069797A1 AR 069797 A1 AR069797 A1 AR 069797A1 AR P080105518 A ARP080105518 A AR P080105518A AR P080105518 A ARP080105518 A AR P080105518A AR 069797 A1 AR069797 A1 AR 069797A1
Authority
AR
Argentina
Prior art keywords
antibody
heavy chain
antigen
replaced
specifically binds
Prior art date
Application number
ARP080105518A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR069797A1 publication Critical patent/AR069797A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/522—CH1 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente también está relacionada con su elaboracion y su utilizacion. Reivindicacion 1: Un anticuerpo bivalente biespecífico que comprende: a) la cadena ligera y la cadena pesada de un anticuerpo que se une específicamente a un primer antígeno, en el que el dominio CH3 de la cadena pesada se reemplaza por un dominio constante CH1 de la cadena pesada; b) la cadena ligera y la cadena pesada de un anticuerpo que se une específicamente a un segundo antígeno, en el que el dominio constante CH3 de la cadena pesada está reemplazado por un dominio constante CL de la cadena ligera. Reivindicacion 2: El anticuerpo de acuerdo con la reivindicacion 1, que se caracteriza porque la cadena ligera y la cadena pesada de dicho primer anticuerpo que se une específicamente a un primer antígeno o dicho segundo anticuerpo que se une específicamente a un segundo antígeno están alteradas porque los dominios variables VL y VH están reemplazados el uno por el otro; y/o porque los dominios variables CL y CH1 están reemplazados el uno por el otro.
ARP080105518A 2007-12-21 2008-12-18 Anticuerpos especificos bivalentes AR069797A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07024866 2007-12-21

Publications (1)

Publication Number Publication Date
AR069797A1 true AR069797A1 (es) 2010-02-17

Family

ID=39684152

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080105518A AR069797A1 (es) 2007-12-21 2008-12-18 Anticuerpos especificos bivalentes

Country Status (15)

Country Link
US (1) US8227577B2 (es)
EP (1) EP2238173A1 (es)
JP (1) JP2011507489A (es)
KR (1) KR101266659B1 (es)
CN (1) CN101903405A (es)
AR (1) AR069797A1 (es)
AU (1) AU2008340695A1 (es)
BR (1) BRPI0821405A2 (es)
CA (1) CA2709347A1 (es)
CL (1) CL2008003782A1 (es)
IL (1) IL205750A0 (es)
MX (1) MX2010005682A (es)
PE (1) PE20091520A1 (es)
TW (1) TW200932270A (es)
WO (1) WO2009080254A1 (es)

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CL2008003782A1 (es) 2010-02-12
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US20090175851A1 (en) 2009-07-09
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BRPI0821405A2 (pt) 2015-06-16

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