ZA200005866B - CD19xCD3 specific polypeptides and uses thereof. - Google Patents
CD19xCD3 specific polypeptides and uses thereof. Download PDFInfo
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- ZA200005866B ZA200005866B ZA200005866A ZA200005866A ZA200005866B ZA 200005866 B ZA200005866 B ZA 200005866B ZA 200005866 A ZA200005866 A ZA 200005866A ZA 200005866 A ZA200005866 A ZA 200005866A ZA 200005866 B ZA200005866 B ZA 200005866B
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Classifications
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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- A61P35/00—Antineoplastic agents
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
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- General Engineering & Computer Science (AREA)
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- Microbiology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Applications Claiming Priority (1)
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| EP98107269 | 1998-04-21 |
Publications (1)
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| ZA200005866B true ZA200005866B (en) | 2001-04-18 |
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| ZA200005866A ZA200005866B (en) | 1998-04-21 | 2000-10-20 | CD19xCD3 specific polypeptides and uses thereof. |
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| EP (2) | EP1071752B1 (fr) |
| JP (1) | JP4169478B2 (fr) |
| KR (1) | KR100508289B1 (fr) |
| CN (1) | CN1302103C (fr) |
| AT (1) | ATE244758T1 (fr) |
| AU (1) | AU761587B2 (fr) |
| BR (1) | BRPI9909860B8 (fr) |
| CA (1) | CA2326389C (fr) |
| CU (1) | CU23252B7 (fr) |
| CZ (1) | CZ302070B6 (fr) |
| DE (1) | DE69909459T2 (fr) |
| DK (1) | DK1071752T3 (fr) |
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| HU (1) | HU229039B1 (fr) |
| ID (1) | ID27512A (fr) |
| IL (2) | IL138857A0 (fr) |
| NO (1) | NO326523B1 (fr) |
| NZ (1) | NZ507381A (fr) |
| PL (1) | PL199747B1 (fr) |
| PT (1) | PT1071752E (fr) |
| RU (1) | RU2228202C2 (fr) |
| SI (1) | SI1071752T1 (fr) |
| SK (1) | SK286683B6 (fr) |
| TR (1) | TR200003087T2 (fr) |
| WO (1) | WO1999054440A1 (fr) |
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| KR100508289B1 (ko) * | 1998-04-21 | 2005-08-17 | 마이크로메트 에이지 | Ｃｄ１９×ｃｄ３ 특이 폴리펩티드 및 그의 용도 |
| ATE311199T1 (de) | 1999-05-07 | 2005-12-15 | Genentech Inc | Behandlung von autoimmunkrankheiten mit antagonisten die oberflächenmarker von b zellen binden |
| US8119101B2 (en) | 1999-05-10 | 2012-02-21 | The Ohio State University | Anti-CD74 immunoconjugates and methods of use |
| US7829064B2 (en) | 1999-05-10 | 2010-11-09 | Immunomedics, Inc. | Anti-CD74 immunoconjugates and methods |
| US8383081B2 (en) | 1999-05-10 | 2013-02-26 | Immunomedics, Inc. | Anti-CD74 immunoconjugates and methods of use |
| EP1543839B1 (fr) * | 1999-06-09 | 2017-09-20 | Immunomedics, Inc. | Immunothérapie de troubles auto-immuns à l'aide d'anticorps ciblant les cellules B |
| AU782160B2 (en) * | 1999-06-09 | 2005-07-07 | Immunomedics Inc. | Immunotherapy of autoimmune disorders using antibodies which target B-cells |
| DE19962583A1 (de) * | 1999-12-23 | 2001-06-28 | Mueller Hermelink Hans Konrad | Antikörper gegen Plasmazellen |
| US7446179B2 (en) | 2000-11-07 | 2008-11-04 | City Of Hope | CD19-specific chimeric T cell receptor |
| US20080260731A1 (en) * | 2002-03-01 | 2008-10-23 | Bernett Matthew J | Optimized antibodies that target cd19 |
| US9770517B2 (en) | 2002-03-01 | 2017-09-26 | Immunomedics, Inc. | Anti-Trop-2 antibody-drug conjugates and uses thereof |
| US20160279239A1 (en) | 2011-05-02 | 2016-09-29 | Immunomedics, Inc. | Subcutaneous administration of anti-cd74 antibody for systemic lupus erythematosus and autoimmune disease |
| US7425618B2 (en) | 2002-06-14 | 2008-09-16 | Medimmune, Inc. | Stabilized anti-respiratory syncytial virus (RSV) antibody formulations |
| US9453251B2 (en) | 2002-10-08 | 2016-09-27 | Pfenex Inc. | Expression of mammalian proteins in Pseudomonas fluorescens |
| US7820166B2 (en) | 2002-10-11 | 2010-10-26 | Micromet Ag | Potent T cell modulating molecules |
| RU2005141512A (ru) * | 2003-05-31 | 2007-07-20 | Микромет Аг (De) | Фармацевтические композиции, включающие биспецифические анти-cd3, анти-cd19 конструкции антител для лечения расстройств, связанных с b-клетками |
| DE602004025101D1 (de) | 2003-05-31 | 2010-03-04 | Micromet Ag | Humane anti-humane cd3-bindungsmoleküle |
| WO2005048917A2 (fr) | 2003-06-06 | 2005-06-02 | Medimmune, Inc. | Utilisation du epha4 et de ses modulateurs, pour le diagnostic, le traitement et la prevention du cancer |
| US7902338B2 (en) | 2003-07-31 | 2011-03-08 | Immunomedics, Inc. | Anti-CD19 antibodies |
| EP2216342B1 (fr) * | 2003-07-31 | 2015-04-22 | Immunomedics, Inc. | Anticorps anti-CD19 |
| ES2358427T3 (es) | 2003-10-16 | 2011-05-10 | Micromet Ag | Elementos de unión a cd-3 desinmunizados multiespecíficos. |
| ATE459374T1 (de) * | 2003-11-28 | 2010-03-15 | Micromet Ag | Polypeptide enthaltende zusammensetzungen |
| US7235641B2 (en) | 2003-12-22 | 2007-06-26 | Micromet Ag | Bispecific antibodies |
| US8883160B2 (en) | 2004-02-13 | 2014-11-11 | Ibc Pharmaceuticals, Inc. | Dock-and-lock (DNL) complexes for therapeutic and diagnostic use |
| US9550838B2 (en) | 2004-02-13 | 2017-01-24 | Ibc Pharmaceuticals, Inc. | Dock-and-lock (DNL) complexes for therapeutic and diagnostic use |
| DE602005022830D1 (de) * | 2004-02-16 | 2010-09-23 | Micromet Ag | Weniger immunogene bindungsmoleküle |
| EP1774017B1 (fr) | 2004-07-26 | 2013-05-15 | Pfenex Inc. | Procede permettant d'ameliorer l'expression d'une proteine par mise au point d'une souche par genie genetique |
| JP2008518023A (ja) | 2004-10-27 | 2008-05-29 | メディミューン，インコーポレーテッド | 同族抗原に対する親和性を改変することによる抗体特異性の調節 |
| CA2597924C (fr) * | 2005-02-15 | 2018-10-02 | Duke University | Anticorps anti-cd19 et leur utilisation en oncologie |
| US10058621B2 (en) | 2015-06-25 | 2018-08-28 | Immunomedics, Inc. | Combination therapy with anti-HLA-DR antibodies and kinase inhibitors in hematopoietic cancers |
| US9707302B2 (en) | 2013-07-23 | 2017-07-18 | Immunomedics, Inc. | Combining anti-HLA-DR or anti-Trop-2 antibodies with microtubule inhibitors, PARP inhibitors, bruton kinase inhibitors or phosphoinositide 3-kinase inhibitors significantly improves therapeutic outcome in cancer |
| US20160355591A1 (en) | 2011-05-02 | 2016-12-08 | Immunomedics, Inc. | Subcutaneous anti-hla-dr monoclonal antibody for treatment of hematologic malignancies |
| US8349332B2 (en) | 2005-04-06 | 2013-01-08 | Ibc Pharmaceuticals, Inc. | Multiple signaling pathways induced by hexavalent, monospecific and bispecific antibodies for enhanced toxicity to B-cell lymphomas and other diseases |
| US8475794B2 (en) | 2005-04-06 | 2013-07-02 | Ibc Pharmaceuticals, Inc. | Combination therapy with anti-CD74 antibodies provides enhanced toxicity to malignancies, Autoimmune disease and other diseases |
| RS54127B1 (en) | 2005-04-18 | 2015-12-31 | Amgen Research (Munich) Gmbh | ANTIBODIES NEUTRALIZERS OF THE HUMAN FACTOR OF STIMULATION OF THE COLONIA OF THE GRANULLocyte MACROPHAGUS |
| CA2606081C (fr) | 2005-04-26 | 2013-09-17 | Markus M. Heiss | Combinaison d'anticorps et de glucocorticoides destinee au traitement du cancer |
| JP5215180B2 (ja) | 2005-06-20 | 2013-06-19 | メダレックス インコーポレーティッド | Ｃｄ１９抗体およびその使用法 |
| WO2007024715A2 (fr) * | 2005-08-19 | 2007-03-01 | Abbott Laboratories | Immunoglobuline a deux domaines variables et utilisations de celle-ci |
| ES2856451T3 (es) | 2005-10-11 | 2021-09-27 | Amgen Res Munich Gmbh | Composiciones que comprenden anticuerpos específicos para diferentes especies, y usos de las mismas |
| JP5442998B2 (ja) * | 2005-12-16 | 2014-03-19 | アムゲン リサーチ （ミュンヘン） ゲーエムベーハー | 腫瘍性疾患を処置するための手段および方法 |
| BRPI0620632A2 (pt) | 2005-12-21 | 2011-12-20 | Micromet Ag | composições farmacêuticas com resistência a cea solúvel, processo de produção das mesmas, usos de anticorpo bi-especìfico de cadeia simples, molécula de ácido nucléico, vetor e hospedeiro na preparação de composição farmacêuticas, e kits |
| US20090221024A1 (en) * | 2006-03-02 | 2009-09-03 | Antitope Limited | T cell assays |
| US8524867B2 (en) | 2006-08-14 | 2013-09-03 | Xencor, Inc. | Optimized antibodies that target CD19 |
| WO2008031056A2 (fr) * | 2006-09-08 | 2008-03-13 | Medimmune, Llc | Anticorps anti-cd19 humanisés, et leur utilisation dans le traitement de l'oncologie, de la transplantation et de la maladie auto-immune |
| KR101940944B1 (ko) † | 2007-04-03 | 2019-01-22 | 암젠 리서치 (뮌헨) 게엠베하 | 종간 특이적 ｃｄ３―입실론 결합 도메인 |
| KR101626988B1 (ko) * | 2007-04-03 | 2016-06-02 | 암젠 리서치 (뮌헨) 게엠베하 | 종간 특이적 이중특이적인 결합제들 |
| HUE040467T2 (hu) | 2007-04-03 | 2019-03-28 | Amgen Res Munich Gmbh | Keresztfaj-specifikus kötõdomén |
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- 1999-04-21 PT PT99924816T patent/PT1071752E/pt unknown
- 1999-04-21 EP EP99924816A patent/EP1071752B1/fr not_active Expired - Lifetime
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