YU47790B - Postupak za dobijanje novih farmakološki aktivnih kateholnih derivata - Google Patents

Postupak za dobijanje novih farmakološki aktivnih kateholnih derivata

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Publication number
YU47790B
YU47790B YU2289A YU2289A YU47790B YU 47790 B YU47790 B YU 47790B YU 2289 A YU2289 A YU 2289A YU 2289 A YU2289 A YU 2289A YU 47790 B YU47790 B YU 47790B
Authority
YU
Yugoslavia
Prior art keywords
optionally substituted
formula
compound
hydrogen
cyano
Prior art date
Application number
YU2289A
Other languages
English (en)
Serbian (sr)
Other versions
YU2289A (en
Inventor
R.J. Backstrom
K.E. Heinola
E.J. Honkanen
S.K. Kaakkola
P.J. Kairisalo
J-B.Y. Linden
P.T. Mannis-To
E.A.O. Nissinen
P. Pohto
A.K. Pippuri
J.J. Pys-Tynene
Original Assignee
Orion Yhtyma Oy.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26158050&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=YU47790(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from FI864875A external-priority patent/FI864875A0/fi
Application filed by Orion Yhtyma Oy. filed Critical Orion Yhtyma Oy.
Publication of YU2289A publication Critical patent/YU2289A/xx
Publication of YU47790B publication Critical patent/YU47790B/sh

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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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Abstract

POSTUPAK ZA DOBIJANJE NOVIH FARMAKOLOSKI AKTIVNIH KATEHOLNIH DERIVATA formule I u kojoj R1 i R2 nezavisno obuhvataju vodonik, opciono supstituisani acil, opciono supstituisani aroil, X je elektronegativni supstituent kao sto je halogen, nitro, cijano, ili aldehid, i R3 obuhvata grupu u kojoj R8 i R9 nezavisno predstavljaju vodonik ili jednu od sledecih opciono supstituisanih grupa: alkil, alkenil, alkinil, cikloalkil, aralkil ili uzeti zajedno formiraju opciono supstituisanu piperidil grupu, n aznacen time, sto jedinjenje formule X u kojoj R1 i R2 predstavljaju opciono supstituisani acil ili aroil, X ima napred navedeno znacenje, i Y je halogen, reaguje sa aminom for-mule XI u kojoj R8 je vodonik i R9 je adamantil ili opciono supstituisani alkil ili opciono supstituisani piperidil, pri cemu se reakcija izvodi uz mesanje najpre na 0°C a zatim na temperaturi okoline, u dihlor-metanu uz upotrebu male kolicine trietilamina ili 2,6-lutidina, dajuci jedinjenje formule Ie u kojoj R1, R2, X, R8 i R9 imaju napred navedena znacenja, i po zelji, ako je potrebno, ovo jedinjenje moze da se podvrgne hidrolizi uz upotrebu katalitickih kolicina sumporne kiseline i uz refluks u metanolu, i prevede u odgovarajuce jedinjenje u kome R1 i R2 oba su vodonik.
YU2289A 1986-11-28 1989-01-06 Postupak za dobijanje novih farmakološki aktivnih kateholnih derivata YU47790B (sr)

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FI864875A FI864875A0 (fi) 1986-11-28 1986-11-28 Nya farmakologiskt aktiva foereningar, dessa innehaollande kompositioner samt foerfarande och mellanprodukter foer anvaendning vid framstaellning av dessa.
GB878712437A GB8712437D0 (en) 1986-11-28 1987-05-27 Pharmacologically active compounds

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YU2189A YU48020B (sh) 1986-11-28 1989-01-06 Postupak za dobijanje novih farmakoloških aktivnih ketholnih derivata
YU2289A YU47790B (sr) 1986-11-28 1989-01-06 Postupak za dobijanje novih farmakološki aktivnih kateholnih derivata

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EG18338A (en) 1992-09-30
NL194821C (nl) 2003-04-03
JPH085781B2 (ja) 1996-01-24
NZ222729A (en) 1990-04-26
FR2607493B1 (fr) 1994-08-12
BG60407B2 (bg) 1995-02-28
AU8187987A (en) 1988-06-02
IS1753B (is) 2000-07-21
CS844088A3 (en) 1992-05-13
ES2008359A6 (es) 1989-07-16
GB2200109B (en) 1991-07-03
IT8722790A0 (it) 1987-11-27
IS3290A7 (is) 1988-05-29
GB8727854D0 (en) 1987-12-31
IT1225762B (it) 1990-11-26
PL152642B1 (en) 1991-01-31
DE3740383A1 (de) 1988-06-01
NO874966D0 (no) 1987-11-27
MTP1012B (en) 1988-10-18
YU48020B (sh) 1996-10-09
LV10236A (lv) 1994-10-20
FR2607493A1 (fr) 1988-06-03
AR243491A1 (es) 1993-08-31
LU87050A1 (fr) 1988-05-03
PT86236B (pt) 1990-11-07
US4963590A (en) 1990-10-16
NL300136I1 (nl) 2003-12-01
DE3740383C2 (de) 1997-09-25
AU621036B2 (en) 1992-03-05
ATA312987A (de) 1995-10-15
CN87108011A (zh) 1988-06-08
JPS63170311A (ja) 1988-07-14
JP2735834B2 (ja) 1998-04-02
NL194821B (nl) 2002-12-02
HU206073B (en) 1992-08-28
IE873242L (en) 1988-05-28
NO874966L (no) 1988-05-30
DE19975025I2 (de) 2000-08-24
CS276263B6 (en) 1992-05-13
PH26145A (en) 1992-03-18
IE60320B1 (en) 1994-06-29
YU2189A (en) 1989-12-31
YU213587A (en) 1989-06-30
CS843988A3 (en) 1992-01-15
GR871817B (en) 1988-03-24
AT401053B (de) 1996-06-25
CA1289078C (en) 1991-09-17
MA21120A1 (fr) 1988-07-01
DK175394B1 (da) 2004-09-20
LV10236B (en) 1995-06-20
NO171450B (no) 1992-12-07
SE8704751D0 (sv) 1987-11-27
PL269091A1 (en) 1988-12-08
HUT45473A (en) 1988-07-28
YU2289A (en) 1989-12-31
CS277018B6 (en) 1992-11-18
SE8704751L (sv) 1988-05-29
GB2200109A (en) 1988-07-27
BE1003279A5 (fr) 1992-02-18
PT86236A (en) 1987-12-01
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HK75594A (en) 1994-08-12
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SE503434C2 (sv) 1996-06-17
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CN1040062C (zh) 1998-10-07
CA1334967C (en) 1995-03-28
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