IT1225762B - Composti farmacologicamente attivi, procedimenti per la loro preparazione e composizioni che li contengono. - Google Patents

Composti farmacologicamente attivi, procedimenti per la loro preparazione e composizioni che li contengono.

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Publication number
IT1225762B
IT1225762B IT8722790A IT2279087A IT1225762B IT 1225762 B IT1225762 B IT 1225762B IT 8722790 A IT8722790 A IT 8722790A IT 2279087 A IT2279087 A IT 2279087A IT 1225762 B IT1225762 B IT 1225762B
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Italy
Prior art keywords
procedures
preparation
active compounds
compositions containing
pharmacologically active
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IT8722790A
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English (en)
Other versions
IT8722790A0 (it
Inventor
Reijo Johannes Backstrom
Kalevi Evert Heinola
Erkki Juhani Honkanen
Seppo Kalevi Kaakkola
Pekka Juhani Kairisalo
Inge Britt Yvonne Linden
Pekka Topias Mannisto
Erkki Aarne Olavi Nissinen
Pentti Pohto
Aino Kyllikki Pippuri
Original Assignee
Orion Yhtymae Oy
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Priority claimed from FI864875A external-priority patent/FI864875A0/fi
Application filed by Orion Yhtymae Oy filed Critical Orion Yhtymae Oy
Publication of IT8722790A0 publication Critical patent/IT8722790A0/it
Application granted granted Critical
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/333—Radicals substituted by oxygen or sulfur atoms
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C07C205/20—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to carbon atoms of six-membered aromatic rings
    • C07C205/21—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to carbon atoms of six-membered aromatic rings having nitro groups and hydroxy groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C205/22—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to carbon atoms of six-membered aromatic rings having nitro groups and hydroxy groups bound to carbon atoms of the same non-condensed six-membered aromatic ring having one nitro groups bound to the ring
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    • C07C205/21—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to carbon atoms of six-membered aromatic rings having nitro groups and hydroxy groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C205/23—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to carbon atoms of six-membered aromatic rings having nitro groups and hydroxy groups bound to carbon atoms of the same non-condensed six-membered aromatic ring having two nitro groups bound to the ring
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    • C07C205/36—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
    • C07C205/37—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
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    • C07C205/43—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups having nitro groups or esterified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
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    • C07C45/562—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with nitrogen as the only hetero atom
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    • C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
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    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
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    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
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    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
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    • C07C59/40—Unsaturated compounds
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    • C07C59/40—Unsaturated compounds
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    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
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IT8722790A 1986-11-28 1987-11-27 Composti farmacologicamente attivi, procedimenti per la loro preparazione e composizioni che li contengono. IT1225762B (it)

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DK623087D0 (da) 1987-11-27
EG18338A (en) 1992-09-30
MA21120A1 (fr) 1988-07-01
ES2008359A6 (es) 1989-07-16
GB2200109B (en) 1991-07-03
DK175394B1 (da) 2004-09-20
HK75594A (en) 1994-08-12
JPS63170311A (ja) 1988-07-14
YU2289A (en) 1989-12-31
SE8704751L (sv) 1988-05-29
CS276263B6 (en) 1992-05-13
DK623087A (da) 1988-05-29
NO874966L (no) 1988-05-30
NL194821B (nl) 2002-12-02
FR2607493B1 (fr) 1994-08-12
RU2014319C1 (ru) 1994-06-15
GB8727854D0 (en) 1987-12-31
GB2200109A (en) 1988-07-27
DE3740383C2 (de) 1997-09-25
IS3290A7 (is) 1988-05-29
FR2607493A1 (fr) 1988-06-03
HUT45473A (en) 1988-07-28
CN1040062C (zh) 1998-10-07
JPH085781B2 (ja) 1996-01-24
NO171450C (no) 1993-03-17
YU213587A (en) 1989-06-30
AR243491A1 (es) 1993-08-31
YU47790B (sr) 1996-01-09
PT86236A (en) 1987-12-01
PH26145A (en) 1992-03-18
CS843988A3 (en) 1992-01-15
IE873242L (en) 1988-05-28
IS1753B (is) 2000-07-21
NL300136I2 (nl) 2004-02-02
YU48020B (sh) 1996-10-09
NZ222729A (en) 1990-04-26
ATA312987A (de) 1995-10-15
NL8702857A (nl) 1988-06-16
NL194821C (nl) 2003-04-03
JP2735834B2 (ja) 1998-04-02
NL300136I1 (nl) 2003-12-01
CN87108011A (zh) 1988-06-08
PT86236B (pt) 1990-11-07
YU2189A (en) 1989-12-31
CH685436A5 (de) 1995-07-14
DE19975025I2 (de) 2000-08-24
AU8187987A (en) 1988-06-02
PL152642B1 (en) 1991-01-31
CS277018B6 (en) 1992-11-18
MTP1012B (en) 1988-10-18
BE1003279A5 (fr) 1992-02-18
LV10236A (lv) 1994-10-20
IT8722790A0 (it) 1987-11-27
CA1334967C (en) 1995-03-28
HU206073B (en) 1992-08-28
DE3740383A1 (de) 1988-06-01
LV10236B (en) 1995-06-20
NO171450B (no) 1992-12-07
PL269091A1 (en) 1988-12-08
IE60320B1 (en) 1994-06-29
JPS63150237A (ja) 1988-06-22
CA1289078C (en) 1991-09-17
SE8704751D0 (sv) 1987-11-27
GR871817B (en) 1988-03-24
AU621036B2 (en) 1992-03-05
LU87050A1 (fr) 1988-05-03
CS844088A3 (en) 1992-05-13
AT401053B (de) 1996-06-25
BG60407B2 (bg) 1995-02-28
NO874966D0 (no) 1987-11-27
SE503434C2 (sv) 1996-06-17
US4963590A (en) 1990-10-16

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