DE602005017204D1 - Verfahren zur herstellung von hochreinem (e)-n,n-diethyl-2-cyano-3-(3,4-dihydro-5-nitrophenyl)acrylamid (entacapon) - Google Patents

Verfahren zur herstellung von hochreinem (e)-n,n-diethyl-2-cyano-3-(3,4-dihydro-5-nitrophenyl)acrylamid (entacapon)

Info

Publication number
DE602005017204D1
DE602005017204D1 DE602005017204T DE602005017204T DE602005017204D1 DE 602005017204 D1 DE602005017204 D1 DE 602005017204D1 DE 602005017204 T DE602005017204 T DE 602005017204T DE 602005017204 T DE602005017204 T DE 602005017204T DE 602005017204 D1 DE602005017204 D1 DE 602005017204D1
Authority
DE
Germany
Prior art keywords
diethyl
cyano
nitrophenyl
organic
acrylamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005017204T
Other languages
English (en)
Inventor
Venkatasubramanian Radha Tarur
Dhananjay Govind Sathe
Nandu Baban Bhise
Avinash Venkatraman Naidu
Umesh Parashram Aher
Sachin Shivaji Patil
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
USV Pvt Ltd
Original Assignee
USV Pvt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by USV Pvt Ltd filed Critical USV Pvt Ltd
Publication of DE602005017204D1 publication Critical patent/DE602005017204D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/32—Separation; Purification; Stabilisation; Use of additives
    • C07C253/34—Separation; Purification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE602005017204T 2005-11-09 2005-11-09 Verfahren zur herstellung von hochreinem (e)-n,n-diethyl-2-cyano-3-(3,4-dihydro-5-nitrophenyl)acrylamid (entacapon) Active DE602005017204D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IN2005/000363 WO2007054950A1 (en) 2005-11-09 2005-11-09 A process for the preparation of highly pure (e) n,n-diethyl-2-cyano-3-(3,4-dihydroxy- 5-nitro phenyl) acrylamide (entacapone)

Publications (1)

Publication Number Publication Date
DE602005017204D1 true DE602005017204D1 (de) 2009-11-26

Family

ID=36910913

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005017204T Active DE602005017204D1 (de) 2005-11-09 2005-11-09 Verfahren zur herstellung von hochreinem (e)-n,n-diethyl-2-cyano-3-(3,4-dihydro-5-nitrophenyl)acrylamid (entacapon)

Country Status (5)

Country Link
US (1) US20080319226A1 (de)
EP (1) EP1945607B1 (de)
AT (1) ATE445591T1 (de)
DE (1) DE602005017204D1 (de)
WO (1) WO2007054950A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009084031A2 (en) * 2007-12-03 2009-07-09 Neuland Laboratories Ltd An improved process for preparation of (2e)-2-cyano-3-(3,4- dihydroxy-5-nitrophenyl)n,n-diethyl-2-propenamide polymorphic form a
EP2251323B1 (de) * 2009-05-14 2014-04-23 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Verfahren zur Reinigung von Entacapon
CN104402764A (zh) * 2014-11-26 2015-03-11 千辉药业（安徽）有限责任公司 一种恩他卡朋的制备方法
CN105061259A (zh) * 2015-08-25 2015-11-18 重庆植恩药业有限公司 一种恩他卡朋a型晶的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU213587A (en) * 1986-11-28 1989-06-30 Orion Yhtymae Oy Process for obtaining new pharmacologic active cateholic derivatives
GB2238047B (en) * 1989-11-03 1993-02-10 Orion Yhtymae Oy Stable polymorphic form of (e)-n,n-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide and the process for its preparation
AU2003296838A1 (en) * 2003-12-24 2005-08-11 Siddiqui Mohammed Jaweed Mukarram An efficient process for the manufacture of (e)-entacapone polymorphic form a
CA2551791A1 (en) * 2003-12-29 2005-07-21 Wockhardt Limited Stable polymorphs of (e)-n,n-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide
CA2552099C (en) * 2003-12-29 2011-10-04 Suven Life Sciences Ltd Improved process for the preparation of entacapone
EP1713768A2 (de) * 2003-12-31 2006-10-25 Cilag AG Neue kristalline formen von entacapone und deren herstellung

Also Published As

Publication number Publication date
ATE445591T1 (de) 2009-10-15
WO2007054950A1 (en) 2007-05-18
EP1945607A1 (de) 2008-07-23
EP1945607B1 (de) 2009-10-14
US20080319226A1 (en) 2008-12-25

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN