ATE445591T1 - Verfahren zur herstellung von hochreinem (e)-n,n- diethyl-2-cyano-3-(3,4-dihydro-5- nitrophenyl)acrylamid (entacapon) - Google Patents

Verfahren zur herstellung von hochreinem (e)-n,n- diethyl-2-cyano-3-(3,4-dihydro-5- nitrophenyl)acrylamid (entacapon)

Info

Publication number
ATE445591T1
ATE445591T1 AT05826478T AT05826478T ATE445591T1 AT E445591 T1 ATE445591 T1 AT E445591T1 AT 05826478 T AT05826478 T AT 05826478T AT 05826478 T AT05826478 T AT 05826478T AT E445591 T1 ATE445591 T1 AT E445591T1
Authority
AT
Austria
Prior art keywords
diethyl
cyano
nitrophenyl
acrylamide
organic
Prior art date
Application number
AT05826478T
Other languages
English (en)
Inventor
Venkatasubramanian Tarur
Dhananjay Sathe
Nandu Bhise
Avinash Naidu
Umesh Aher
Sachin Patil
Original Assignee
Usv Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Usv Ltd filed Critical Usv Ltd
Application granted granted Critical
Publication of ATE445591T1 publication Critical patent/ATE445591T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/32—Separation; Purification; Stabilisation; Use of additives
    • C07C253/34—Separation; Purification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT05826478T 2005-11-09 2005-11-09 Verfahren zur herstellung von hochreinem (e)-n,n- diethyl-2-cyano-3-(3,4-dihydro-5- nitrophenyl)acrylamid (entacapon) ATE445591T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IN2005/000363 WO2007054950A1 (en) 2005-11-09 2005-11-09 A process for the preparation of highly pure (e) n,n-diethyl-2-cyano-3-(3,4-dihydroxy- 5-nitro phenyl) acrylamide (entacapone)

Publications (1)

Publication Number Publication Date
ATE445591T1 true ATE445591T1 (de) 2009-10-15

Family

ID=36910913

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05826478T ATE445591T1 (de) 2005-11-09 2005-11-09 Verfahren zur herstellung von hochreinem (e)-n,n- diethyl-2-cyano-3-(3,4-dihydro-5- nitrophenyl)acrylamid (entacapon)

Country Status (5)

Country Link
US (1) US20080319226A1 (de)
EP (1) EP1945607B1 (de)
AT (1) ATE445591T1 (de)
DE (1) DE602005017204D1 (de)
WO (1) WO2007054950A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009084031A2 (en) * 2007-12-03 2009-07-09 Neuland Laboratories Ltd An improved process for preparation of (2e)-2-cyano-3-(3,4- dihydroxy-5-nitrophenyl)n,n-diethyl-2-propenamide polymorphic form a
EP2251323B1 (de) * 2009-05-14 2014-04-23 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Verfahren zur Reinigung von Entacapon
CN104402764A (zh) * 2014-11-26 2015-03-11 千辉药业（安徽）有限责任公司 一种恩他卡朋的制备方法
CN105061259A (zh) * 2015-08-25 2015-11-18 重庆植恩药业有限公司 一种恩他卡朋a型晶的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU213587A (en) * 1986-11-28 1989-06-30 Orion Yhtymae Oy Process for obtaining new pharmacologic active cateholic derivatives
GB2238047B (en) * 1989-11-03 1993-02-10 Orion Yhtymae Oy Stable polymorphic form of (e)-n,n-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide and the process for its preparation
WO2005070881A1 (en) * 2003-12-24 2005-08-04 Wockhardt Limited An efficient process for the manufacture of (e)-entacapone polymorphic form a
EP1699753B1 (de) * 2003-12-29 2014-11-26 Suven Life Sciences Limited Verbessertes verfahren zur herstellung von entacapon
AU2003292465A1 (en) * 2003-12-29 2005-08-12 Siddiqui Mohammed Jaweed Mukarram Stable polymorphs of (e)-n,n-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide
WO2005063696A2 (de) * 2003-12-31 2005-07-14 Cilag Ag Neue kristalline formen von entacapone und deren herstellung

Also Published As

Publication number Publication date
US20080319226A1 (en) 2008-12-25
EP1945607B1 (de) 2009-10-14
DE602005017204D1 (de) 2009-11-26
EP1945607A1 (de) 2008-07-23
WO2007054950A1 (en) 2007-05-18

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