WO2015169428A2 - Nebulizer - Google Patents

Nebulizer Download PDF

Info

Publication number
WO2015169428A2
WO2015169428A2 PCT/EP2015/000900 EP2015000900W WO2015169428A2 WO 2015169428 A2 WO2015169428 A2 WO 2015169428A2 EP 2015000900 W EP2015000900 W EP 2015000900W WO 2015169428 A2 WO2015169428 A2 WO 2015169428A2
Authority
WO
WIPO (PCT)
Prior art keywords
nebulizer
locking
container
indicator device
spring
Prior art date
Application number
PCT/EP2015/000900
Other languages
English (en)
French (fr)
Other versions
WO2015169428A3 (en
Inventor
Joachim Eicher
Josef GATZ
Markus Mueller
Herbert Wachtel
Original Assignee
Boehringer Ingelheim International Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to BR112016023720-0A priority Critical patent/BR112016023720B1/pt
Priority to CN201580022298.9A priority patent/CN106232166B/zh
Application filed by Boehringer Ingelheim International Gmbh filed Critical Boehringer Ingelheim International Gmbh
Priority to ES15724938T priority patent/ES2853775T3/es
Priority to PL15724938T priority patent/PL3139981T3/pl
Priority to AU2015258107A priority patent/AU2015258107B2/en
Priority to MX2016014399A priority patent/MX2016014399A/es
Priority to DK15724938.4T priority patent/DK3139981T3/da
Priority to NZ724463A priority patent/NZ724463B2/en
Priority to KR1020167033120A priority patent/KR102382358B1/ko
Priority to JP2016566222A priority patent/JP6643252B2/ja
Priority to CA2948066A priority patent/CA2948066C/en
Priority to EP15724938.4A priority patent/EP3139981B1/en
Priority to US15/308,879 priority patent/US10716907B2/en
Priority to EA201692239A priority patent/EA032832B1/ru
Publication of WO2015169428A2 publication Critical patent/WO2015169428A2/en
Publication of WO2015169428A3 publication Critical patent/WO2015169428A3/en
Priority to IL247926A priority patent/IL247926B/en
Priority to PH12016502190A priority patent/PH12016502190A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/006—Sprayers or atomisers specially adapted for therapeutic purposes operated by applying mechanical pressure to the liquid to be sprayed or atomised
    • A61M11/007—Syringe-type or piston-type sprayers or atomisers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A61M15/0025—Mouthpieces therefor with caps
    • A61M15/0026—Hinged caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A61M15/0035—Piercing means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A61M15/0035—Piercing means
    • A61M15/0036—Piercing means hollow piercing means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A61M15/004—Details of the piercing or cutting means with fixed piercing or cutting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A61M15/0041—Details of the piercing or cutting means with movable piercing or cutting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/007—Mechanical counters
    • A61M15/0071—Mechanical counters having a display or indicator
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/007—Mechanical counters
    • A61M15/0071—Mechanical counters having a display or indicator
    • A61M15/0073—Mechanical counters having a display or indicator on a ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/0081—Locking means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
    • B05B11/1042—Components or details
    • B05B11/108—Means for counting the number of dispensing strokes
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06M—COUNTING MECHANISMS; COUNTING OF OBJECTS NOT OTHERWISE PROVIDED FOR
    • G06M3/00—Counters with additional facilities
    • G06M3/02—Counters with additional facilities for performing an operation at a predetermined value of the count, e.g. arresting a machine
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06M—COUNTING MECHANISMS; COUNTING OF OBJECTS NOT OTHERWISE PROVIDED FOR
    • G06M3/00—Counters with additional facilities
    • G06M3/02—Counters with additional facilities for performing an operation at a predetermined value of the count, e.g. arresting a machine
    • G06M3/021—Counters with additional facilities for performing an operation at a predetermined value of the count, e.g. arresting a machine with drums type indicating means
    • G06M3/022—Counters with additional facilities for performing an operation at a predetermined value of the count, e.g. arresting a machine with drums type indicating means by subtracting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/0007—Special media to be introduced, removed or treated introduced into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0468—Liquids non-physiological
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/12—General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/27—General characteristics of the apparatus preventing use
    • A61M2205/273—General characteristics of the apparatus preventing use preventing reuse, e.g. of disposables
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/27—General characteristics of the apparatus preventing use
    • A61M2205/276—General characteristics of the apparatus preventing use preventing unwanted use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/583—Means for facilitating use, e.g. by people with impaired vision by visual feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/586—Ergonomic details therefor, e.g. specific ergonomics for left or right-handed users
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2207/00—Methods of manufacture, assembly or production
    • A61M2207/10—Device therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2209/00—Ancillary equipment
    • A61M2209/06—Packaging for specific medical equipment
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/0005—Components or details
    • B05B11/0037—Containers
    • B05B11/0054—Cartridges, i.e. containers specially designed for easy attachment to or easy removal from the rest of the sprayer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06M—COUNTING MECHANISMS; COUNTING OF OBJECTS NOT OTHERWISE PROVIDED FOR
    • G06M1/00—Design features of general application
    • G06M1/02—Housing

Definitions

  • the present invention relates to a nebulizer according to the preamble of claim 1 , 2 or 16.
  • WO 2012/162305 A1 discloses a nebulizer.
  • a container can be inserted into a housing of the nebulizer.
  • the housing is closed by a lower housing part.
  • the drive spring can be put under tension and fluid can be sucked into a compression chamber of the pressure generator.
  • the container is moved into the lower housing part in a stroke movement within the nebulizer and when tensioned for the first time the container may be pierced through its base by a piercing element in the lower housing part to allow venting of the container.
  • the drive spring is released and moves the delivery tube into the pressure chamber so that the fluid is put under pressure by the drive spring and is delivered or atomized through a nozzle into a mouthpiece as an aerosol, without the use of propellant gas.
  • the container is moving axially forth and back during conveying of the fluid to be nebulized, and during pressure generation and nebulization.
  • the container may be connected inseparably with the housing part by a securing device forming a transportation lock for holding the container unmovable in a delivery state.
  • the nebulizer comprises an indicator device for counting and/or indicating a number of uses performed or still possible.
  • the indicator device blocks further use in a locked state when a predetermined number of uses has been reached or exceeded with the current container. Then, the container can be replaced together with a housing part and the nebulizer can be used further with the new container.
  • US 7,823,584 B2 discloses a similar nebulizer, wherein a counter device can be integrated into a housing part that is exchangeable or replaceable together with the container, which is inseparable from the housing part.
  • the nebulizer comprises a locking device for blocking the lower housing part and an inner housing part against further rotation in a second locked state after a predetermined number of containers has been used to finally lock the nebulizer against any further use.
  • This locking device comprises a spring as locking element which radially engages into an upper housing part of the nebulizer to block any further rotation when the nebulizer has been tensioned for the last time. The rotational locking cannot be unlocked again.
  • WO 2007/104694 A1 discloses an inhaler for powdery substances with an indi- cator device which may comprise a worm gear for driving an indicator element.
  • Object of the present invention is to provide a nebulizer allowing easy and/or secure operation and handling and/or a compact and/or reliable construction, preferably while allowing replacement of the container without replacement of any housing part of the nebulizer.
  • the present invention relates to a nebulizer for nebulizing a fluid, preferably liquid medicament, from a preferably replaceable container containing the fluid.
  • a nebulizer for nebulizing a fluid, preferably liquid medicament, from a preferably replaceable container containing the fluid.
  • an indicator device is provided for counting and/or indicating the number of uses already performed or still possible with the container.
  • the indicator device controls or causes a locking device to lock the nebulizer against further use in a locked state when a predetermined number of uses has been reached or exceeded with the respective container.
  • the nebulizer comprises a housing part which can be detached from the nebulizer or opened for replacing the container.
  • the locking device or a locking element thereof is adapted to block any (further) rotation of the nebulizer, in particular of a lower or detachable and/or inner housing part relative to an upper housing part of the nebulizer.
  • the nebulizer cannot be tensioned or prepared for the next use, so that e.g. any pumping or dispensing of fluid is prevented, when the rotation is blocked in the locked state.
  • (complete) tensioning is necessary for preparing the nebulizer for next use, i.e. next nebulization of fluid.
  • the locking device or locking element is adapted to block the rotation preferably before a complete tensioned state or position of the nebulizer is reached and/or in an intermediate position or partially tensioned state, most preferably in the second half of the total rotation angle necessary for (completely) tensioning the nebulizer.
  • the container is replaceable preferably only in an at least partially tensioned state of the nebulizer such that complete closing of the nebulizer or its housing is not possible when the indicator device is in the locked state.
  • This allows easy and/or secure operation and handling.
  • a user can easily realize that the indicator device preferably together with the container has to be changed and cannot be reused when the nebulizer cannot be closed.
  • a locking element of the locking device axially engages by form-fit and/or with multiple, pref- erably rib-like engagement portions into respective pockets or vice versa in a locking position to block the rotation.
  • the locking device comprises preferably an axially moveable locking member interacting with the locking element via an inclined surface for radially moving the locking element preferably outwards into the locking position.
  • the locking element is formed by or comprises a sliding block.
  • the locking element or sliding block is preferably (only) radially moveable. This allows secure operation and/or simple construction, wherein a very quick locking can be achieved even if the nebulizer or its housing part is rotated with high speed. Further, a simple construction or easy operation for unlocking or release are possible.
  • the locking device and/or locked state can preferably be reset to release or unlock the rotation locking.
  • This allows replacement of the container and indicator device, wherein the nebulizer and its housing part can be reused, while a very secure locking and, thus, secure operation can be realized in the locked state.
  • the container cannot be used anymore in the locked state when the indicator device has detected that a predetermined number of uses has been reached or exceeded, in particular with the respective container.
  • the indicator device may either directly or indirectly lock or initiate or trigger locking of the nebulizer and/or container against further use.
  • the indicator device may directly actuate the locking device or indirectly initiate actuation of the locking device.
  • the indirect actuation is realized by means or via at least partial opening of the nebulizer or its housing or housing part in order to lock the nebulizer against further use with the current container.
  • the nebulizer is blocked (automatically) against further use or tensioning if the nebulizer housing or housing part is at least partially open or opened or if, with other words, when the nebulizer or its housing is not (com- pletely) closed.
  • the nebulizer is not immediately blocked against further use when the indicator device enters the locked state.
  • the indicator device may initiate or cause or trigger in its locked state that the locking device is going to block the nebulizer against further use, e.g. during the next actuation or tensioning or the like.
  • the locking device may enter its locking state later, e.g. after at least partial opening of the nebulizer and/or at least partial tensioning of the nebulizer or rotation of the housing part or inner part of the nebulizer or the like.
  • the blocking of the nebulizer can be initiated or caused by the indicator device not only indirectly, but alternatively or additionally also later during further handling, operation, actuation or the like.
  • the indicator device blocks or initiates or causes blocking of the nebulizer and/or container against further use also preferably in the sense of the present invention.
  • the locking of the nebulizer against further use can be overcome by replacing the container, in particular including the indicator device, against one not yet used.
  • the indicator device is inseparably connected with the container or with a container housing of the container, but separable from the nebulizer or its housing and from the housing part, so that the indicator device is replaceable together with the container.
  • This allows reuse of the nebulizer and the housing part with another container including another indicator device.
  • the overall size of the components to be exchanged is kept small, so that the replacement packages are size reduced, so that transport of a large number of packages is facilitated.
  • the indicator device is fixedly arranged at a bottom of the container and/or opposite to an outlet of the container. This allows a very compact construction. Further, the indicator device does not interfere with the fluidic connec- tion of the container to the nebulizer or vice versa.
  • Fig. 2 a schematic section, rotated 90° compared with Fig. 1 , of the known nebulizer in a tensioned state;
  • Fig. 3 a schematic section of a nebulizer with an inserted container in a non-tensioned state according to a preferred embodiment of the present invention
  • Fig. 4 a partial enlargement of the encircled part of Fig. 3;
  • Fig. 5 a perspective view of the section of the nebulizer according to Fig.
  • FIG. 6 an enlargement of the encircled part of Fig. 5;
  • Fig. 7 a schematic exploded view of an indicator device according to a preferred embodiment of the present invention.
  • Fig. 8 an axial section of the indicator device in an actuated state; an axial section of the indicator device in a locked state; a perspective section of the indicator device in an actuated state; a perspective section of the indicator device in an released state; a partial enlargement of the nebulizer similar to Fig. 4, but in a partially tensioned state; a partial enlargement of the nebulizer similar to Fig. 4, but in a fully tensioned state; a partial section of the nebulizer similar to Fig. 4, but in an intermediate state during a dispensing stroke; a partial section of the nebulizer similar to Fig.
  • Fig. 23 a partial schematic section of the nebulizer with unlocked locking device according to another embodiment
  • Fig. 24 a perspective section of the nebulizer with the unlocked locking device according to a further embodiment.
  • Fig. 25 a schematic section similar to Fig. 24 with the locking device in the locking position.
  • Figs. 1 and 2 show a known nebulizer 1 for atomizing a fluid 2, particularly a highly effective pharmaceutical composition, medicament or the like, diagram- matically shown in a non-tensioned state (Fig. 1 ) and in a tensioned state (Fig. 2).
  • the nebulizer 1 is constructed in particular as a portable inhaler and preferably operates only mechanical and/or without propellant gas.
  • an aerosol 14 (Fig. 1 ) is formed or dispensed, which can be breathed in or inhaled by a user.
  • the inhaling is done at least once a day, more particularly several times a day, preferably at set intervals, depending on the complaint or illness from which a patient is suffering.
  • the nebulizer 1 is provided with or comprises an insertable or replaceable container 3 containing the fluid 2.
  • the container 3 thus forms a reservoir for the fluid 2, which is to be nebulized.
  • the container 3 contains multiple doses of fluid 2 or active substance in particular sufficient to provide up to 200 dosage units or doses, for example, i.e. to allow up to 200 sprays or applications.
  • a typical container 3, as disclosed in WO 96/0601 1 A1 holds e.g. a volume of about 2 to 20 ml.
  • the number of doses contained in the container 3 and/or the total volume of the fluid 2 contained in the container 3 can vary depending on the fluid 2 or respective medicament and/or depending on the container 3 and/or depending on the necessary medication or the like.
  • the container 3 can be replaced or exchanged, wherein the total number of uses of the nebulizer 1 and thus the number of containers 3, which can be used with the same nebulizer 1 , is preferably restricted, e.g. to a total number of four or five containers 3.
  • WO 2012/162305 A1 discloses additionally such a restriction to the total numbers of containers 3 which can be used with the same nebulizer 1 .
  • the container 3 is preferably substantially cylindrical or cartridge-shaped and once the nebulizer 1 has been opened the container 3 can be inserted therein preferably from below and changed if desired. It is preferably of rigid construction, the fluid 2 in particular being held in a collapsible bag 4 in the container 3.
  • the container 3 comprises a venting opening or hole 23 which is opened before or during first use.
  • the nebulizer 1 comprises a delivery mechanism, preferably a pressure generator 5, for conveying and nebulizing the fluid 2, particularly in a preset and option- ally in an adjustable dosage amount.
  • the nebulizer 1 or pressure generator 5 comprises preferably a holder 6 for re- leasably holding the container 3, a drive spring 7 associated to the holder 6, only partly shown, and/or a blocking element 8 preferably in form of or with a button for preferably manual actuation or depressing.
  • the blocking element 8 can catch and block the holder 6 and can be manually operated to release the holder 6 allowing drive spring 7 to expand.
  • the nebulizer 1 or pressure generator 5 comprises preferably a conveying ele- ment, such as a conveying tube 9, a non-return valve 10, a pressure chamber 1 and/or an nozzle 12 for nebulizing the fluid 2 into a mouthpiece 13.
  • a conveying ele- ment such as a conveying tube 9, a non-return valve 10, a pressure chamber 1 and/or an nozzle 12 for nebulizing the fluid 2 into a mouthpiece 13.
  • the completely inserted container 3 is fixed or held in the nebulizer 1 via the holder 6 such that the conveying element fluidically connects the container 3 to the nebulizer 1 or pressure generator 5.
  • the conveying tube 9 penetrates into the container 3.
  • the nebulizer 1 or holder 6 is preferably constructed so that the container 3 can be exchanged.
  • the nebulizer 1 operates with a spring pressure of 5 to 200 MPa, preferably 10 to 100 M Pa on the fluid 2, and/or with a volume of fluid 2 delivered per stroke of 10 to 50 ⁇ , preferably 1 0 to 20 ⁇ , most preferably about 15 ⁇ .
  • the fluid 2 is converted into or nebulized as aerosol 14, the droplets of which have an aerodynamic diameter of up to 20 ⁇ , preferably 3 to 10 ⁇ .
  • the generated jet spray has an angle of 20° to 160°, preferably 80° to 100°.
  • a user or patient can inhale the aerosol 14, preferably while an air supply can be sucked into the mouthpiece 13 through at least one optional air supply opening 15.
  • the nebulizer 1 comprises preferably a housing 24 and/or (upper) housing part 16 and optionally a biasing or inner part 17 preferably which is rotatable relative thereto (Fig. 2) and/or has an upper part 17a and a lower part 17b (Fig. 1 ).
  • the nebulizer 1 or housing 24 comprises preferably a (lower) housing part 18.
  • This part 18 is in particular manually operable, and/or releasable fixed, particu- larly fitted or held onto the inner part 7, preferably by means of a retaining element 19.
  • the housing parts 16 and 18 and/or other parts form the housing 24 of the nebulizer 1.
  • the housing 24 can be opened and/or the housing part 18 can be detached from the nebulizer 1 , inner part 17 or housing 24.
  • the container 3 can be inserted before the housing 24 is closed and/or before the housing part 18 is connected to the housing 24.
  • the container 3 may be inserted, opened and/or fluidically connected to the delivery mechanism automatically or simultaneously when (completely) connecting the housing part 18 to the housing 24 / nebulizer 1 and/or when (completely) closing the housing 24 / nebulizer 1.
  • the container 3 is open or fluidically connected when tensioning the nebulizer 1 for the first time with the current container 3.
  • the nebulizer 1 or drive spring 7 can be manually activated or tensioned or loaded, in particular by actuation of an actuation member, here preferably by rotating housing part 18 or any other component.
  • the actuation member preferably the housing part 18, can be actuated, here ro- tated relative to the upper housing part 16, carrying with it or driving the inner part 17.
  • the inner part 17 acts on a gear or transmission to transform the rotation in an axial movement.
  • the drive spring 7 is tensioned in the axial direction by means of the gear or transmission (not shown) formed between the inner part 17, in particular its upper part 17a, and the holder 6 and acting on the holder 6.
  • the container 3 is moved axially downwards until the container 3 assumes an end position as shown in Fig. 2.
  • the drive spring 7 is under tension and can be caught or held by the blocking element 8.
  • the housing part 18 preferably forms a cap-like lower housing part and/or fits around or over a lower free end portion of the container 3.
  • the container 3 moves with its end portion (further) into the housing part 18 or towards the end face thereof, while an aeration means, such as an ax- ially acting spring 20 arranged in the housing part 18, comes in contact with base 21 of the container 3 and pierces the container 3 or a base seal or foil 50 thereon with a piercing element 22 when the container 3 makes contact with it for the first time, to allow air in or aeration, preferably by opening or piercing venting hole 23.
  • the venting hole 23 allows for pressure compensation inside the container 3 when fluid 2 is drawn from the container 3 during the actuation of the nebulizer 1.
  • the nebulizer 1 comprises preferably an indicator device 25, which counts in particular actuations of the nebulizer 1 , preferably by detecting its tensioning or the rotation of the inner part 17 relative to the upper part 16 or housing 24.
  • the counter device 25 or an associated locking device 26 locks the nebulizer 1 against (further) actuation or use, e.g. blocks further rotation of the housing part 18 / inner part 17 and, thus, tensioning of the nebulizer 1 or its drive spring 7 and/or blocks actuation of the blocking element 8, in a locked state when a certain number of actuations or operations or discharged doses has been reached or exceeded.
  • the locking device 26 is controlled or controlable by the indicator device 25.
  • nebulizer 1 container 3, indicator device 25 and/or locking device 26 is described and shown according to the invention, wherein primarily important aspects and differences will be described and the previous aspects, features and explanations apply preferably additionally or correspondingly even without repetition.
  • Fig. 3 shows the nebulizer 1 with the container 3 and indicator device 25 according the present invention in a schematic section (longitudinal section) in the non- tensioned state with completely closed nebulizer housing 24 and, thus, closed housing part 18, wherein the container 3 including the proposed indicator device 25 are inserted into or received within the nebulizer 1 and/or housing 24.
  • Fig. 4 shows an enlarged partial section of the encircled part of Fig. 3.
  • Fig. 5 shows a perspective view of the section of the nebulizer 1 of Fig. 3.
  • Fig. 6 shows a partial enlargement of the encircled part of Fig. 5.
  • the nebulizer 1 has preferably a longitudinal form or axis which corresponds to the axial direction and/or to the main dispensing direction and/or to stroke movement of the container 3 during tensioning and dispensing.
  • the nebulizer 1 or its mouthpiece 13 is prefer- ably closed by a mouthpiece cover 27.
  • the mouthpiece cover 27 is preferably pivotable to allow opening of the mouthpiece 13 for using the nebulizer 1 .
  • the indicator device 25 is directly and/or unreleasably secured or fixed to or connected with the container 3.
  • the indicator device 25 is associated to a respective container 3. If the container 3 of the nebulizer 1 is replaced, the indicator device 25 is necessarily or positively replaced as well.
  • the indicator device 25 is fixedly arranged at the bottom or container base 21 of the container 3 and/or opposite to an outlet or head 28 of the con- tainer 3.
  • the indicator device 25 is preferably directly connected to or abuts at an outer case or preferably rigid housing 29 of the container 3.
  • the indicator device 25 and the container 3 are connected by form-fit and/or snap-fit.
  • the indicator device 25 circumvents and/or grips over a (lower or bottom) edge 30 and/or any other protrusion or the like of the container 3.
  • the edge 30 is a little bit wider in diameter so that it protrudes radially over the essentially cylindrical outer form of the side wall of the container 3 / container housing 29.
  • the diameter of the indicator device 25 is preferably at least essentially equal to or slightly greater than the diameter of the container 3 or its edge 30.
  • the edge 30 is preferably formed between the side wall and the bottom or base 21 of the container 3 or container housing 29.
  • the edge 30 is formed by flanging, bordering, bending or crimping or by any other suitable material- deforming process.
  • the indicator device 25 comprises a housing 31 and/or preferably has an at least essentially cylindrical form.
  • the indicator device 25 or its housing 31 is preferably attached to the container 3 or its base 21 or housing 29 with an at least essentially flat and/or axial side.
  • the indicator device 25 or its housing 31 comprises preferably a holding or gripping section 32 for connecting the indicator device 25 with the container 3.
  • the gripping section 32 circumvents the edge 30 and/or grips around or over the edge 30.
  • the gripping section 32 is preferably annular and/or grips over the edge 31 at positions distributed over the circumference of the edge 30 or container 3.
  • the indicator device 25 and the container 3 are connected with each other by a snap-fit or click connection.
  • the container 3 and the indicator device 25 are connected with each other by axially snapping one part on the other.
  • the gripping section 32 is sufficiently elastic in radial direction so that the container 3 can be entered axially with its edge 30.
  • the gripping section 32 preferably comprises a respectively inclined insertion face to facilitate insertion of edge 30 into the annular gripping section 32 or between circumferentially distributed gripping sections 32.
  • Fig. 7 shows in a schematic, exploded view the indicator device 25 according to the preferred embodiment of the present invention.
  • the indicator or its housing 31 comprises preferably an upper part 33 and a low- er part 34.
  • the upper part 33 holds or forms the gripping section 32.
  • the indicator device 25 comprises preferably an indicator element 35 and an associated actuation element 36 and/or a transmission 40 or gear 41 for indexing the indicator element 35 or for causing the indexing of the indicator element 35.
  • the indicator device 25 is for counting and/or indicating a number of uses per- formed or still possible with the respective or associated container 3.
  • the indicator element 35 comprises markings 37, such as one or more symbols, numbers, coloured or shaded areas or the like, for at least roughly indicating the number of uses already performed with or still possible with the respective container 3.
  • the indicator element 35 is preferably rotat- able and/or comprises a circumferential wall or outer surface with the at least one marking 37.
  • the indicator housing 31 comprises preferably a window 31 a, in particular in the circumferential wall through the relevant marking 37 is visible for a user or pa- tient, preferably through the housing part 18 which is in particular transparent.
  • the actuation element 36 comprises preferably an actuation arm 38 which, intern comprises preferably a free or actuation end 39, for direct or indirect actuation or indexing of the indicator element 35. Indexing means that the indicator element 35 is moved forward in increments or steps.
  • the transmission 40 results in a reduction and/or is re- alized as a worm device.
  • the indicator device 25 or transmission 40 comprises preferably a gear 41 and/or a worm 42.
  • the worm 42 is directly formed by the gear 41 so that the gear 41 forms a worm gear and preferably comprises radially protruding teeth 43 in which at least one convolution of the worm 42 is formed (compare the horizontal or axial sections of the mounted indicator device 25 shown in Figs. 8 and 9).
  • the gear 41 comprises preferably an axle, in particular one or more axle sections 44 which may axially protrude on opposite sides as realized in the present embodiment.
  • the actuation element 36 causes a rotation of the gear 41 around an axis preferably perpendicular to the direction of movement of the actuation element 36, the axis preferably being arranged in a horizontal plane identical or parallel to the plane given by the movement of the actuation element 36.
  • the gear 41 is rotatably held preferably by the housing 31 or lower housing part 34, preferably by two bearing sections 45 of the lower part 34.
  • the bearing sections 45 comprises recesses for rotatably holding the axle sections 44.
  • other constructional solutions are possible as well.
  • the housing 31 or lower part 34 bears preferably the indicator element 35 such that it can rotate.
  • the lower part 34 comprises preferably two bearing portions 46 arranged on opposite radial sides and axially protruding for rotatably bearing the indicator element 35.
  • the actuation element 35 and/or transmission 40 are preferably arranged at least essentially in between the bearing portions 46.
  • the indicator device 25 comprises preferably an actuation spring 47, in particular for biasing the actuation element 36 into a preferred direction and/or for driving the indicator element 35
  • Fig. 8 shows in a horizontal or axial section the mounted indicator device 25 in an actuated state where the actuation element 36 has been moved or pushed sidewards, namely starting from the first position shown in Figs. 3 to 6 towards the left into a second position which is shown in Fig. 8.
  • Fig. 9 shows in a similar section as Fig. 8 the indicator device 25 in a locked state where the actuation element 36 is in a locked, third position. It can been seen from Figs. 8 and 9 that protrusions 60 of the indicator element 35 (not shown in Figs. 8 and 9) extend axially, wherein always at least one protrusion 60 is caught in the worm 42 so that a worm drive is formed between the gear 41 and the indicator element 35. Thus, any rotation of gear 41 is trans- formed in a reduced rotation of the indicator element 35. Further, a permanent engagement between the gear 41 and the indicator element 35, more precisely between at least one protrusion 60 and the worm 42, is ensured. However, other constructional solutions or couplings between the gear 41 and the indicator element 35 are possible.
  • Fig. 10 shows the mounted indicator device 25 in a perspective section in the initial, first position and state.
  • Fig. 1 1 shows the indicator device 25 in a similar perspective section, but with released actuation element 36, i.e. just before the locked state is reached.
  • the transmission 40 or gear 41 forms a worm (helical groove) 42 with at least one convolution, preferably a with about 1 .5 or more convolutions, so that always at least one engaging element of the indicator element 35 or of any other transmission component, in particular the inwardly or axially projecting pro- trusion 60, engages in the worm 42.
  • rotation of the gear 41 around its preferably transversal axis results in a rotation of the indicator element 35 around its preferably longitudinally oriented rotation axis.
  • other constructional solutions are possible as well.
  • the teeth 43 are relatively long and/or extend radially sufficiently so that the protrusions are securely guided within the convolutions of the worm 42, in between the teeth 43, and that the actuation portion 39 can still move in radial direction between the protrusion 60 engaging into the worm 42 and the gear 41 in order to actuate or rotate the gear 41 in the desired manner.
  • the actuation portion 39 may engage into respectively deep cut outs between the teeth 43 in order to be able to move below the respective projection 60.
  • the indicator device 25 comprises preferably a piercing part 48 (compare Fig. 3 to 6).
  • the piercing part 48 is arranged within the indicator device 25 or its housing 31 .
  • the piercing part 48 is preferably axially moveable.
  • the piercing part 48 is preferably moveable such that it can protrude towards the container 3 and/or can open an aeration opening, preferably the venting hole 23, of the container 3, in particular by breaking or piercing a foil 50 covering the venting hole 23.
  • the piecing element 48 comprises preferably an opening end or tip 49 which can open or pierce the foil 50 covering the container base 21 , in particular an indention 51 formed in the container 3 or its base 21 .
  • the indention 51 comprises a break through which forms the venting hole 23.
  • other constructional solutions are possible as well.
  • Fig. 12 shows in a partial enlargement similar to Fig. 4 a lower portion of the nebulizer 1 in an intermediate state after partial tensioning.
  • the indicator device 25 is in an actuated state as shown in Fig. 8 (second position).
  • the nebulizer 1 or housing part 18 comprises preferably a driving part 52 for driving or actuating the indicator device 25 when using the nebulizer 1 , in particular for actuating the indicator device 25 in response to any tensioning of the nebulizer 1 and/or any (axial or stroke-like) movement of the container 3.
  • the driving part 52 is arranged or formed in the housing part 18, in particular on the axial end face or bottom 53 of the housing part 18.
  • the driving part 52 is arranged centrally and/or extends axially.
  • the driving part 52 is at least substantially cylindrical and/or pin-like or bolt-like.
  • the driving part 52 is held by the housing part 18 and/or integrally formed by the housing part 18.
  • the movement of the container 3 and, thus, of the indicator device 25 during the tensioning (downward movement in the drawings) and/or during pressurization and dispensing (upward movement in the drawings) and/or one or both of the respective end positions in the non-tensioned state and tensioned state, respectively, can be used for actuating the indicator device 25, i.e. for counting.
  • the relative movement of the container 3 and/or indicator device 25 within the nebulizer 1 is used for actuating or triggering the indicator device 25 and/or counting.
  • the driving part 25 When tensioning the nebulizer 1 and/or moving the indicator device 25 downwards, the driving part 25 enters or engages through an insertion opening 54 of the indicator device 25 or its housing 31 , in particular axially.
  • the driving part 52 and the insertion opening 54 are arranged centrally and/or axially aligned.
  • the driving part 52 actuates the actuation element 36, i.e. moves the actuation element 36 from an initial first position shown in Fig. 3 to 6, to an actuated second position shown in Fig. 9.
  • the actuation spring 47 biases the actuation element 36 into the first position.
  • the actuation element 36 is moveable back and forth between the first and second positions for indexing the indicator element 35, in particular for incrementally rotating the gear 41 in one direction to respectively drive the indicator element 35.
  • any rotation of gear 41 is transformed in a reduced rotation of the indicator element 35, thus every movement of the actuation element 36 from the first to the second position or vice versa results in a movement of the indicator element 35.
  • the actuation element 36 is moveable transversally, preferably perpendicularly, to the longitudinal or dispensing direction of the con- tainer 3 or nebulizer 1 and/or to the stroke movement of the container 3 and/or indicator device 25.
  • the actuation element 36 is moved from the more central first position radially outwards to the second position, in particular against the force of the associated, preferably helical actuation spring 47 biasing the actuation element 36 in opposite direction.
  • the actuation element 36 In the second position, the actuation element 36 has been moved with its actuation arm 38 or actuation portion 39 out of engagement with gear 41 as indicated in Figs. 8 and 12.
  • Fig. 13 shows in a similar enlarged section as Fig. 12 the fully tensioned state.
  • the container 3, more precisely the aeration opening or venting hole 23, is opened at least when the nebulizer 1 is tensioned with a container 3 for the first time.
  • the opening of the container 3 or venting hole 23 for aeration is realized by piercing or breaking, in particular of foil 50.
  • the opening or piercing can be effected directly by the driving part 52.
  • the opening or piercing can be effected independently from the driving part 52, e.g. by means of the aeration spring 20 with the piercing element 22 similar to the embodiment shown in Fig. 2.
  • the opening or piercing can be achieved indirectly, preferably via the piercing part 48 which is preferably actuated by the driving part 52.
  • the piercing part 48 is formed as separate part and/or provided by the indicator device 25 and/or arranged within the indicator device 25.
  • the piercing part 48 is held axially moveable by a support structure 55 of the indicator device 25, housing 31 , upper part 32 and/or indicator element 35, as schematically indicated in Figs. 10 and 1 1 .
  • the piercing part 48 and/or the support structure 55 are a one-piece- construction with a further part of the indicator devices 25, e.g. with the indicator element 35 or with the indicator housing 31 , especially with the upper part 33 of the indicator housing 31 .
  • the piercing part 48, support structure 55 and the further part of the indicator device 25 are made of plastic in an injection molding process.
  • the support structure 55 comprises flexible arms or ribs for holding the piercing part 48 axially moveable.
  • the piercing part 48 can be constructed as separate, axially moveable part, which is optionally spring biased in the longitudinal or axial direction away from the container 3, so that the piercing tip 49 is retracted from the container 3 in the non-tensioned state.
  • the piercing part 48 or its tip 49 is preferably received within the indicator device 25 or its housing 31 , but can protrude outwards in the actuated state.
  • the opening or piercing can be repeated each time the nebulizer 1 is tensioned, i.e. each time when the container 3 reaches its end position in the tensioned state.
  • the piercing part 48 may be biased into its retracted or initial position shown in Fig. 3 to 6, in particular by a preferably integrally formed biasing arm, spring or the like, preferably by the support structure 55.
  • the piercing part 48 may comprise a compensation portion, such as a flexible arm 56, for compensating any tolerances in axial direction. Such tolerances can occur in particular due to variations during production, in particular variations of the length of the container 3 and/or other components, variations of the connections of the container 3 with the indicator device 25, variations of the length of the indicator device 25 or its housing 31 , variations of the axial position of the container 3 within the holder 6, and the like. Thus, different distances between the free end of driving part 52 and the counter-face of the piercing part 48 can result.
  • the construction is such that the driving part 52 and the piercing part 48 cooperate in any case such that the desired piercing is ensured.
  • the compensation portion allows axial compression - here by radial flexing of arms 56 - when a predetermined axial force is exceeded in order to avoid any damage of the container 3 and/or any other component of the nebulizer 1 .
  • the driving part 52 first moves the piercing part 48 towards the container base 21 into the piercing position and further axial movement of the driving part 52 is compensated by the compensation portion, prefer- ably by the flexible arms 56 being spread radially outwards, giving way to the tip of the driving part 52 for entering a central recess in the piercing part 48 (on the side opposite to the piercing tip 49).
  • the piercing part 48 comprises preferably at least one axial channel, in particular one or more axially extending grooves 57 circumferentially distributed around the circumference of tip 49, in order to ensure unblocked aeration or venting even if the piercing part 48 stucks or stays in the foil 50 or piercing position.
  • Fig. 14 shows in a similar enlargement as Fig. 4, 12 and 13 an intermediate state of the pressurization or dispensing process, i.e. when the container 3 has been moved partially upwards again.
  • the driving part 52 has been withdrawn from the indicator device 25 or through the insertion opening 54 par- tially such that the actuation element 36 starts to return to its initial or first position due to the force of the actuation spring 47.
  • the actuation element 36 returns into the first position shown in Figs. 3 to 6 when the back movement is completed.
  • the back movement of the container 3 and/or of the actuation element 36 actuates preferably the indicator device 25 or gear 41 and/or is detected or counted.
  • the actuation element 36 or its arm 38 or actuation portion 39 transmits the back movement or movement from the second to the first position to the transmission 40. In particular, this movement causes an incremental rota- tion of gear 41 .
  • the movement of the container 3 and/or indicator device 25 within the nebulizer 1 during dispensing is preferably used for actuating or triggering the indicator device 25 and/or for counting.
  • the actuation arm 38 or its portion 39 abuts against one tooth 43 of gear 41 during the back movement and, thus, turns the gear 41 due to the back movement one step further, in the drawings in clockwise direction.
  • the indicator device 25 comprises a ratchet 58 preventing any counter-rotation of the transmission 40 or gear 41 .
  • the ratchet 58 is formed by a flexible arm extending from the housing 31 , in particular lower housing part 34, and/or meshing with or engaging into the gear 41 or its teeth 43.
  • the driving part 52 is preferably further or completely retracted from the indicator device 25, the indicator housing 31 and/or insertion opening 54 as shown in Fig. 3 to 6.
  • the transmission 40 or gear 41 transforms the actuation, in particular the (backward) movement of the actuation element 36 or its arm 38 / actuating portion 39, into an indexing of the indicator element 35.
  • the transmission ratio or transmission function of the transmission 40 or gear 41 may be designed or constructed such that a reduction or non-linear driving or indexing is achieved.
  • the transmission 40 or gear 41 forms preferably a worm drive for achieving a desired reduction.
  • the movement of the actuation element 36 - in particular from the first position to the second position - results in that the actuation arm 38 or its actuation por- tion 39 are moved out of engagement with the gear 41 , in particular can be pulled over the next tooth 43.
  • the arm 38 is flexed out.
  • the subsequent movement in opposite direction i.e. the back movement or movement from the second to the first position, results in that the actuation arm 38 or its actuation portion 39 contacts the next tooth 41 and can transmit the at least essential line- ar movement of the arm 38, more precisely the preferably linear movement of the actuation element 36, into a rotation of the gear 41 , more precisely in an indexing of gear 41 by preferably one tooth 43.
  • the teeth 43 are asymmetrical, i.e. comprise differently inclined shoulders on one side and the other side in order to facilitate and/or ensure the incremental actuation and movement in one rotational direction by the back and forth movement and engagement of the actuation arm 38.
  • the actuation element 36 is linearly moveable and/or forms a sliding carriage.
  • the actuation element 36 is supported and/or held moveably by the housing 31 , in particular lower part 34 of the housing 31 .
  • the housing 31 in particular lower part 34 of the housing 31 .
  • other constructional solutions are possible as well.
  • the actuation spring 47 acts preferably between the housing 31 or lower part 34 on one hand and the actuation element 36 on the other hand.
  • the spring 47 is preferably already compressed and/or biased in the first position and/or biases the actuation element 36 such that it at least partially closes or blocks the insertion opening 54.
  • the actuation element 36 comprises an inclined gliding surface 59 at its part protecting into or over the insertion opening 32 in the first position. This surface 59 is inclined such that the insertion of the driving part 52, i.e. its axial movement or abutment, is transformed into a transversal or radial movement of the actuation element 36.
  • such a surface 59 can also be formed at the driving part 52 to achieve the desired transformation of the axial movement into a transversal or radial movement by means of an inclined plane. Therefore, the actuation or rotation of the transmission 40 or gear 41 is preferably effected by the force of the actuation spring 47 or any other pressure or energy store or spring means. This results in the advantage that no additional force is necessary for driving the indicator device 25 or its indicator element 35. Consequently, the pressurization and dispensing process is not disturbed.
  • the triggering of the counting or actuation of the transmission 40 / gear 41 is effected preferably by the pressurization or dispensing process or movement, i.e. during the actual dispensing of fluid 2, i.e. usually during actual use or inhalation.
  • the actuation spring 47 biases the actuation element 36 preferably towards closing the insertion opening 54.
  • the movement of the actuation element 36 is restricted so that it does not completely close the insertion opening 54 before the locked state is reached.
  • This limitation is realized in the present embodiment preferably via a control means or portion 62 against which a control part 63 abuts in particular to restrict the back movement of the actuation element 36 at the first position.
  • the abutment is shown in particular in Fig. 10.
  • other constructional solutions are possible as well.
  • the indicator device 25 comprises a blocking part 61 which blocks further use of the container 3 and/or closes or blocks the insertion opening 54 in the locked state as schematically shown in the schematically enlargement of Fig. 15 which shows a similar part as Fig. 4 and 12 to 14.
  • the container 3 has returned to its non-tensioned position and the driving part 52 has been retracted from the indicator device 25.
  • the indicator device 25 has moved the indicator element 35 one step further and detected or registered that the predetermined number of uses has been reached or exceeded and, thus, that the locked state shall be entered.
  • the indicator element 35 comprises preferably a control portion 62 which releases the actuating element 36 for detection of the locked state which results in locking the nebulizer 1 or current container 3 against further use.
  • control portion 62 comprises a cut out or recess which allows or initiates movement of the blocking part 61 into a blocking position.
  • the blocking part 61 blocks or closes the insertion opening 54 in the blocking position, i.e. in the locked state.
  • control portion 62 is a wall or ridge on the inside of the rotatable indicator element 35.
  • the blocking part 61 is integrated into the indicator device 25 or its housing 31 .
  • the blocking part 61 is preferably moveable transversally or perpendicular to the longitudinal or dispensing direction of the container or nebulizer 1 and/or of the direction of stroke movement of the container 3.
  • the blocking part 61 blocks the actuation or insertion movement of the driving part 52, in particular relative to the indicator device 25 and/or (sufficient) insertion of the driving part 52.
  • the blocking part 61 is linearly moveable and/or formed by a sliding carriage.
  • the blocking part 61 is biased into its blocking position, in the present embodiment preferably by actuation spring 47 or any other suitable biasing means.
  • the blocking part 61 closes or blocks the insertion opening 54 of the indicator device 25 after the last dose of fluid 2 has been dispensed and when the locked state has been entered or detected.
  • This detection is preferably realized in that the blocking part 61 or any associated component, such as control part 63, can pass the control portion 62 in the locked state, most preferably by spring force, in particular by the force of actuation spring 47 or the like, as schematically shown in Fig. 1 1 .
  • the blocking part 61 is connected with or formed by the actuation element 36 or vice versa. Most preferably, the blocking part 61 forms a wall or side, preferably flat side, of the actuation element 36.
  • the blocking part 61 forms a wall or side, preferably flat side, of the actuation element 36.
  • other construc- tional solutions are possible as well.
  • the actuation element 36 can move in the locked state from the first position into the third position, i.e. preferably in the opposite direction than the movement into the second position.
  • the actuation element 36 can close the insertion opening 54 preferably completely in the third position (blocking position).
  • the blocking position of the blocking part 61 corresponds pref- erably to the third position of the actuation element 36.
  • the actuation element 36 In the locked state or third position, the actuation element 36 has moved with the actuation arm 38 or its portion 39 further in the actuation direction so that the actuation portion 39 has passed the previous tooth 43 in the rotation direction of gear 41 as indicated in Fig. 15.
  • the actuation element 36 is constructed to block further use of the container 3 in the locked state or third position (blocking position).
  • the actuation element 36 is moveable back and forth between the first and second position for indexing the indicator element 35 and is moveable into a third position to block further use of the container 3 in the locked state.
  • the closed indicator device 25 or blocking part 61 results in particular in that the container 3 cannot move inside the closed housing of the nebulizer 1 in the stroke-like fashion as previously described and as required for normal or further use so that normal use is prevented.
  • Fig. 16 shows this state (partially tensioned nebulizer 1 with partially opened housing part 18) in a schematic, longitudinal section of the nebulizer 1 .
  • the container 3 is moving downwardly together with the indicator device 25.
  • the indicator device 25 abuts soon with its blocking part 61 / actuating element 36 against the member usually actuating the indicator device 25, here the driving part 52, so that a further usual downward movement is not possible.
  • the blocking part 61 restricts the axial moveability of the container 3 in the nebulizer 1 in the locked state, preferably by preventing the driving part 52 from insertion into the indicator device 25 or restricting its insertion in the locked state. Due to the force applied when tensioning the nebulizer 1 and due to the 0 resulting axial force in the movement of the container 3, the housing part 18 will be moved outwards or relative to the nebulizer 1 , inner part 17 or upper part 16 together with the container 3 and indicator device 25 during the further tensioning movement in axial direction in the locked state. 5
  • the above common downward movement of container 3, indicator device 25 and housing part 18 is possible due to a respectively constructed fastening of the housing part 8 at the nebulizer 1 .
  • the retaining force is select- ed or set such that it can be overcome by the downward movement of the container 3.
  • the retaining element 19 engages with a retaining nose 64 in a respective retaining recess 65 in the housing part 8 or vice versa.
  • substantially an undercut or indention can be realized.
  • the abutting shoulders which extend at least essentially radially of the nose 64 on one hand and the recess 65 on the other hand are slightly inclined, preferably by about 1 ° to 5° to the radial plane such that the axial force of the tensioning pro- cess can overcome the retaining force provided by the engagement of the nose 64 into the recess 65 so that the retaining element 19 is flexed radially and the retaining engagement is overcome. Consequently, the housing part 18 is moved downwardly as well and, thus, is pushed at least partly from the nebulizer 1 or separated from the upper housing part 16 and/or pushed from the inner part 17.
  • This pushing or axial displacement of the housing part 18 or any other opening of the nebulizer 1 results preferably in that the nebulizer 1 is locked against further use by means of the locking device 26. Therefore, the indicator device 25 or its blocking part 61 effects indirectly via the opening of the nebulizer 1 the de- sired locking of the nebulizer 1 in the locked state.
  • the locking device 26 blocks tensioning of the nebulizer 1 in the locked state.
  • the locking device 26 comprises a moveable locking element 66 and an associated locking spring 67.
  • the locking element 66 is preferably axially moveable between a locked position and an unlocked position.
  • the locking element 66 is preferably biased into a locking position / the locked position by the locking spring 67.
  • the locking element 66 In the locked position, the locking element 66 is preferably in its lower axial position shown in Fig. 16. Fig. 17 shows an enlargement of the encircled area of Fig. 16. In the locked position, the locking element 66 blocks rotation of the inner part 17 relative to the outer part 16 and, thus, blocks (further) tensioning of the nebulizer 1 .
  • This is preferably achieved in the present embodiment in that the locking element 66 moves or engages preferably (only) axially into a respective pocket 68 formed in the upper part 16 such that said relative rotation is blocked.
  • the locking element 66 engages with an engagement portion 69 into the respective recess or pocket 68 such that any further rotation and/or back rotation is prevented.
  • other constructional solutions are possible as well.
  • the engagement portion 69 protrudes radially and/or is at least essentially rib-like.
  • the locking element 66 comprises preferably multi- pie or three engagement portions 69 as shown in Fig. 21 which is a schematic side view of the nebulizer 1 in the region of the encircled part of Fig. 16 with opened or cut-away upper housing part 16.
  • Fig. 21 shows the locking element 66 in its unlocked or upper position.
  • the engagement portions 69 extend preferably parallel to each other and/or in axial or actuation direction.
  • the engagement portions 69 are preferably rib-like and/or protrude radially and/or outwardly.
  • the locking element 66 together with the engagement portion(s) 69 is preferably formed by one-piece and/or as an integral or rigid part and/or made preferably of plastics.
  • Fig. 22 shows in a schematic radial section the engagement of the locking device 26 or its locking element 66 in the locked state or position, i.e. the rotational blocking, of the nebulizer 1 , in particular of the inner part 7 and/or lower housing part 18 relative to the upper or outer housing part 16.
  • the engagement portions 69 engage or protrude into separate or corresponding pockets 68 formed at or by (the inner side of) the housing part 16 of the nebulizer 1 .
  • other constructional solutions are possible as well.
  • the locking element 66 is preferably guided by the inner part 17 and/or in a respective groove 75 and/or by a preferably rib-like protrusion 76 or the like, as schematically indicated in Fig. 22, such that the locking element 66 is preferably only axially moveable.
  • a preferably rib-like protrusion 76 or the like as schematically indicated in Fig. 22, such that the locking element 66 is preferably only axially moveable.
  • other constructional solutions are possible as well.
  • the locking device 26, in particular the locking element 66 and the locking spring 5 67, are preferably arranged and/or supported by the inner part 17 and/or extend between the inner part 17 and upper part 16.
  • the nebulizer 1 , inner part 17 or locking device 26 comprises preferably a cover 70 covering the locking device 26 at least on the periphery of the lower part 17b i o of the inner part 17 in order to prevent or at least complicate any undesired manipulation of the locking device 26 or locking element 66 by a user or patient.
  • the locking device 26 or locking element 66 is locking relative rotation or further rotation before the complete tensioned state or position is 15 reached , i.e. preferably in an intermediate position, most preferably in the second half of the total rotation angle necessary for tensioning the nebulizer 1 by turning the lower housing part 18 relative to the upper housing part 16.
  • This intermediate blocking has the advantage that it is preferably not possible to 0 fully actuate the nebulizer 1 as it is not possible to reach complete tensioning and, thus, the gear or transmission transforming the relative rotation into the axial stroke of the holder 6 actually holds the holder 6 in the intermediate position and does not allow any axial back movement into the upper, non-tensioned position.
  • the locking device 26 locks the nebulizer 1 against further tensioning after the complete tensioned state has been reached.
  • the locking device 26 or its 0 locking element 66 locks the release of the spring 7 or holder 6 to dispense the fluid 2, in particular by locking any depression of blocking element 8 and, thus, blocking the release.
  • the locking device 26 or its locking element 66 can be adapted to block additionally the actuation of the nebulizer 1 or block triggering the nebuli- zation of a dose of the fluid 2 or block the depression of the blocking element 8 or any other actuation button or the like of the nebulizer 1 . This may form an additional measure to block further use of the nebulizer 1 in the locked state.
  • the nebulizer 1 or upper part 16 may be enforced by one or more metallic inserts or enforcement elements, which may be ring-like and/or may extend in circumferential direction and/or may be arranged adjacent to or around the pocket 68 and/or adjacent to the lower or free end of the upper part 16.
  • Fig. 18 shows the nebulizer 1 in a similar schematic section as Fig. 16, however with the locking device 26 in the unlocked position, i.e. the locking element 66 in the upper position.
  • the locking device 26 or locking element 66 is brought into this position or unlocked preferably only by closing the nebulizer 1 , in particular by the housing part 18 in the completely attached or closed position.
  • the housing part 18 comprises a preferably finger-like and/or axially extending actuator 71 which extends into the locking device 66 and/or into the cover 70 and/or axially abuts and/or pushes the locking element 66 into its unlocking position (upper position), as shown in Fig. 18.
  • the completely closed nebulizer 1 or housing part 18 unlocks the locking device 26 and, thus, unlocks the nebulizer 1 .
  • the actuator 71 is preferably arranged within the housing part 18 so that any manipulation is not possible or at least complicated.
  • the locking device 26 locks preferably automatically.
  • the locking spring 67 biases the locking element 66 into the locking position, so that upon at least partial opening of the nebulizer 1 or (axial) displacement of its housing part 18, the locking device 26 or its locking element 66 can move and moves into the locking position.
  • the locking element 66 is moveable (essentially or only) in axial di- rection.
  • the nebulizer 1 or its housing part 18 can be closed completely again.
  • the nebulizer 1 or its locking device 26 can be or is unlocked again.
  • the actuator 71 pushes the locking element 66 back into its unlocking position.
  • the locking device 26 or locked state is reset or unlocked again, preferably by (completely) closing the nebulizer 1 , its housing 24 or housing part 18, and the nebulizer 1 can be used with the new container 3 as previously.
  • the locking element 66 is preferably formed by one single part.
  • the locking device 26 may comprise multiple parts forming or containing the locking element 66.
  • the container 3 is or has to be replaced in an at least partially ten- sioned state of the nebulizer 1 , in particular such a tensioned state that complete closing of the nebulizer 1 or its housing 24 is not possible when the indicator device 25 is in the locked state or when the insertion opening 54 is closed.
  • the locking element 66 is (only) axially moveable be- tween the locking and non-locking position and vice versa.
  • the locking element 66 can be moveable alternatively or additionally in radial direction to switch between the locking and non-locking position or vice versa, as explained later with regard to Fig. 24 and 25 showing a further embodiment.
  • the locking element 66 may be pushed radially outwards, in particular to engage in a respective groove or recess or the like in the locking position, in order to block (further) tensioning or use of the nebulizer 1 .
  • the locking element 66 may form or may be formed by a sliding block.
  • the locking spring 67 is preferably arranged at the lower part 17b of the inner part 17 and/or at the lower end of the locking device 26 or locking element 66, or near or adjacent to the housing part 18.
  • the locking spring 67 can also be arranged at the other end and/or within the up- per housing part 16 of the nebulizer 1 as shown in Fig. 23 and/or at any other convenient location.
  • Fig. 23 shows in a partial schematic section the locking device 26 according to another embodiment with differently arranged locking spring 67, namely in the upper housing part 16. It has to be noted that the previous explanations apply also for the other embodiments and all further embodiments described in a similar or a corresponding manner, even if a respective repetition is omitted.
  • the locking spring 67 is preferably a push-spring or compression-spring.
  • a pull-spring could be used alternatively.
  • the locking spring 66 is preferably a helical spring. However, it could be used alternatively e.g. a flat spring or leaf spring or any other spring.
  • Fig. 19 shows in a schematic section the indicator device 25 according to a modified embodiment of the present invention.
  • Fig. 20 shows a perspective view of the section according to Fig. 19.
  • the actuation arm 38 and actuation portion 39 do not engage in between the worm drive, i.e. between the gear 41 and the engag- ing protrusions 60 of the driven part, here namely the indicator element 35, but engage with or actuate the gear 41 on another side or the side opposite the worm drive, here preferably in Fig. 19 from below and not from above.
  • the actuation arm 38 extends more or less in a radial plane and/or more or less in a common plane with the actuation spring 47 and/or blocking part 61 or the sliding carriage part of the actuation element 36.
  • the actuation arm 38 or portion 39 engages with the gear 41 on the side opposite the container 3 or gripping section 32.
  • the indicator device 25 counts preferably when the nebulizer 1 is tensioned, i.e. during the tensioning process and not during the dispensing process as provided in the initial embodiment of the present inven- tion.
  • the actuation element 36 or its arm 38 drives or rotates the transmission 40 or gear 41 , when the driving part 52 is inserted into the indicator device 25, its housing 31 or its insertion opening 54 and/or when the actuation el- ement 36 is moved from the first position to the second position and/or when the actuation element 36 is pushed transversally by the driving part 52.
  • the actuation arm or its actuation portion 39 passes the next tooth 43 of the gear 41 , i.e. does not drive the gear 41 .
  • the indicator device 25 or counting is not driven by the force of the actuation spring 47 or any other spring or energy store, but by the relative movement of the indicator device 25 within the nebulizer 1 or by the insertion of an actuator element, such as the driving part 52.
  • an actuator element such as the driving part 52.
  • the blocking of the carriage / actuation element 36 / locking part 61 to move into the third or locking position are released during the tensioning when a predetermined number of uses is reached or exceeded. Then, the carriage / actuation element 36 / blocking part 61 abut against the driving part 52 because the counting occurs during the tensioning.
  • the nebulizer 1 is actuated or when the blocking element 8 is depressed, the nebulizer 1 is triggered and the (last) dose of fluid 2 is nebulized.
  • the driving part 52 is removed from the indicator device 25 or insertion opening 54 so that the carriage / actuation element 36 / blocking part 61 are free to move into the third or locking position due to the force of the actuation spring 47 or any other spring means.
  • the nebulizer 1 or its housing 24 or housing part 18 will be partially opened when the driving part 52 abuts against the closed indica- tor device 25, in particular against the carriage / actuation element 36 / blocking part 61 restricting or closing the insertion opening 54.
  • the counting or actuating of the indicator device 25 takes place or occurs when dispensing fluid, i.e. when the driving part 52 is withdrawn from the insertion opening 54.
  • the carriage / actuation element 36 / blocking part 61 are released during the last use of the nebulizer 1 or dis- pensing , i.e. when moving from the second to the first position so that the carriage / actuation element 36 / blocking part 61 can move further directly into the third or unlocking position.
  • any later dispensing is not possible.
  • the indicator device 25 blocks full axial or stroke-moveability of the container 3 within the nebulizer 1 in the locked state and/or causes at least partially opening of the nebulizer housing 24 and/or housing part 18 in the locked state, in particular when the nebulizer 1 is tensioned at least partially for the last time with the current container 3.
  • Figs. 19 and 20 show the indicator device 26 according to the present invention in the non-actuated or initial state and/or with the actuation element 36 in the first position.
  • the control part 63 which extends preferably upwards and/or in axial direction, abuts against the preferably ring-like control portion 62 which is preferably formed by or at the indicator element 35.
  • control por- tion 62 has a radial distance to the outer wall of the indicator element 35 so that the control part 63 can move inbetween and that the actuation element 36 is free to move between the first and second positions, while the abutment of the control part 63 against the control portion 62 prevents movement of the actuation element 36 from the first position further towards the third position and/or further to (complete) closing the insertion opening 54.
  • the protrusions 60 are dent-like and/or are tapered towards its free ends.
  • the protrusions 60 are formed on or connected with the control portion 62.
  • the insertion opening 54 is provided preferably with a conical surface or edge to facilitate insertion of the driving part 52 or the like.
  • the support structure 55 forms or comprises one or more flexible arms for moveably holding the piercing part 48, preferably in the center of the indicator device 25 or its housing 31 or a respective opening of the housing 31 , so that the piercing part 48 is usually held inside the indicator device 25 but can move and in particular protrude outwards and/or towards the container 3 for opening or piercing aeration.
  • other constructional solutions are possi- ble.
  • the indicator device 25 and the container 3 form an inseparable assembly or unit, which has to be replaced completely after use, in particular after reaching the locked state.
  • the container 3 and indicator device 25 are supplied or offered as a kit which can be assembled by the use or patient.
  • the indicator device 25 cannot be reset after reaching the locked state so that it cannot be reused. However, it is also possible to modify the indicator device 25 such that it can be reset and reused. In this case, the indicator device 25 has to be separated from the present container 3 and connected with a new (unused) container 3. Most preferably, such a container change would automatically reset the indicator device 25.
  • the insertion opening 54 which is preferably arranged centrally and/or opens in axial direction and/or allows axial insertion of an actuator element, in particular the driving part 52 in the present embodiment, can also be formed as a recess, groove, indention or the like and/or can be arranged at any position or location at the indicator device 25 with any orientation.
  • the insertion opening 54 or its closing can also be omitted.
  • the indicator device 25, actuation element 36 or blocking part 61 can more or less directly communicate with or actuate the locking device 26 or, for example, the retaining element 19 or blocking element 8 in order to cause a direct or indi- rect locking of the nebulizer 1 or container 3 against further use.
  • the actuation element 36 or blocking part 61 is moveable preferably linearly, in particular like a sliding carriage.
  • a sliding carriage is formed.
  • the sliding carriage forms a base part of the actuation element 36 or blocking part 61 .
  • the sliding carriage, actuation element 36 or blocking part 61 is moveably held by sliding guides 72 on opposite sides, preferably on opposite sides of the insertion opening 54, as schematically shown in Figs. 8 and 9.
  • the guides 72 are formed by respective rails or the like of the housing 31 or its lower part 34 which grip over respective edges or base portions 73 of the actuation element 36 or blocking part 61 to form the desired sliding guidance.
  • other constructional solutions are possible as well.
  • any other motion in particular a radial and/or pivotal movement, is possible, in particular for partially or completely closing the insertion opening 54.
  • the actuation element 36 and/or blocking part 61 can move outwards from the indicator device 25 or its housing 31 , preferably transversally and/or at one side of the indicator housing 31 for locking at least one engagement possibility and/or actuating any other component in the locked state or for locking the nebulizer 1 and/or container 3.
  • the actuation element 36 and/or blocking part 61 can engage into or abut against a section or contour of the housing part 18 and/or nebulizer housing 24 or the like in order to restrict or prevent operation or movement in the locked state in order to block further use of the nebulizer 1 and/or container 3 in the locked state.
  • the actuation element 36 and/or blocking part 61 are preferably biased by spring 47 or any other spring means.
  • the spring or spring means can be formed integrally and/or by plastic parts or pieces.
  • a spiral or clock spring or any other spring, such as helical spring 47 or the like, could be used for biasing the actuation element 36 and/or blocking part 61 , preferably into the locked state.
  • the driving part 52 directly drives or actuates the gear 41.
  • the driving part 52 is preferably elastically supported by the housing part 18, in particular via a spring means (not shown), in particular for compensat- ing axial tolerances and/or allowing radial or transversal flexing of the driving part 52.
  • the driving part 52 may be flexible in order to allow transversal flexing for engaging with the gear 41 only in one direction of relative axial movement to the gear 41 to rotate the gear 41 only in one rotational direction.
  • the indicator device 25 can comprise any other counting mechanism, in particular as described in WO 2009/037085 A1 , page 4, line 19 to page 10, line 13, which is incorporated herein by reference. Such a counting mechanism can also trigger, release or actuate the actuation element 36 and/or blocking part 61. When using this counting mechanism, the rotatable indicator element 35 can also release or control the release of the carriage, actuation element 36 or blocking part 61 in the locked state to move into the third or locking position or close the insertion opening 54. It is also possible that the carriage or blocking part 61 is independent from the counting.
  • the driving part 52 may engage the hub of the counting mechanism shown in WO 2009/037085 A1 or the like and/or drive or actuate the indicator device 25 or counting without actuating the carriage or blocking part 61 .
  • the functions are separated.
  • the carriage and/or blocking part 61 are preferably used only for restricting or closing the insertion opening 54 in the locked state, but not for actuating or driving the indicator device 25 of its counting mechanism or transmission 40 or indicator element 35 or the like.
  • the container 3 or indicator device 25 or insertion opening 54 may be provided with an optional protection 74, shown schematically only in Fig. 19, which covers in particular the insertion opening 54 before the first use.
  • the protection 74 has to be removed before the container 3 and/or indicator device 25 can be inserted into the nebulizer 1 or housing part 18.
  • the protection 74 extends transversally over the indicator device 25 or its housing 31 and/or over the container 3 and/or has a larger diameter than the indicator device 25 and/or container 3, in particular such that it does not fit into the nebulizer 1 or housing part 18.
  • the protection 74 can be removed only irreversibly, i.e. cannot be re-connected after removal.
  • the protection 74 covers or closes the insertion opening 54 and/or the indicator device 25.
  • the protection 74 is connected to the indicator device 25 or container 3 by form-fit or force-fit and/or by a snap-fit or click-fit.
  • nebulizer 1 and, in particular, of the locking device 26 will be described with reference to Fig. 24 and 25.
  • the follow- ing description will focus on relevant differences and new aspects in particular in comparison to the embodiment according to Fig. 16 to 18, 21 and 22, wherein the previous explanations and features shall preferably apply respectively or in a corresponding manner for the further and other embodiment even if a respective description is omitted.
  • Fig. 24 shows in a partial schematic section of the nebulizer 1 , the locking device 26 of the further embodiment in the unlocked position.
  • Fig. 25 shows the locking device 26 in a respective section, but in the locked position or state.
  • the locking element 66 is preferably formed as a sliding block which is preferably moveable (only) radially.
  • the locking device 26 comprises preferably a locking member 77 interacting with the locking element 66 via at least one inclined sur- face 78 for actuating , in particular radially moving the locking element 66 into the locking position.
  • the locking element 66 is moved into the locking position by form-fit engagement or actuation, here of the locking member 77 or inclined surface 78.
  • the locking element 66 is preferably moveable positively from the unlocked position into the locked position and/or vice versa.
  • the locking element 66 is preferably moveable back into the unlocked position by form-fit engagement and/or by reverse or upward movement of the locking member 77 and/or engagement or abutment of a respective, preferably inclined control surface 79 of the locking element 66 as schematically shown in Fig. 25.
  • control surface 79 cooperates with a respective wall or angled portion 80 of the locking member 77 as schematically shown in Fig. 25 in order to transform the preferably linear and/or axial movement of the locking member 77 into the lateral or radial - here unlocking or inwards - movement of the locking element 66 into the unlocked position.
  • control surface 79 is formed at or by a control portion 81 of the locking element 66.
  • the inclined control surface 79 can additionally or alternatively be formed or built at or by the angled portion 80 or locking member 77 in order to realize the positive movement, here radially inwards, opposite to the locking movement, here radially outwards.
  • the locking element 66 is preferably reversible from the locking posi- tion into the unlocking position for releasing the rotational blocking or locked state. This is realized in the present embodiment preferably by axial actuation or upward movement of the locking member 77 by the axially abutting actuator 71 when closing the nebulizer 1 or its housing part 18.
  • axial actuation or upward movement of the locking member 77 by the axially abutting actuator 71 when closing the nebulizer 1 or its housing part 18.
  • other constructional solutions are possible as well.
  • the above principle of transforming the axial movement or actuation into a radial movement applies also preferably in the opposite direction, i.e. when actuating or locking the locking element 66.
  • the inclined surface 78 cooperates preferably with a counter portion 82 formed at or by the locking element 66.
  • the locking member 77 comprises preferably two inclined surfaces 78 and the locking element 66 comprises preferably two counter portions 82 in order to precisely move or actuate the locking element 66 and/or to move the locking element 66 without any or minimized tilting.
  • the linear or axial movement or actuation of the locking member 77 can be transformed into a lateral or transversal or radial or outwards movement of the locking element 66 into the locked position shown in Fig. 25.
  • the locking element 66 is held or locked in the locked position by an at least essentially flat or axial bearing portion or surface83,in particular two surfaces 83.
  • the locking member 77 forms the essentially flat or axial bearing surface ⁇ ) 83 to hold or lock the locking element 66 in the locked position.
  • the counter portion(s) 82 can move along the respective inclined surface 78 during the axial - here downward - movement of the locking member 77 and, then, reach the respective bearing surface 83. This state is shown in Fig. 25.
  • the locking element 66 can consist of or the locking device 26 can comprise at least one or more locking elements 66 - preferably with one or multiple engagement portions 69 - distributed around or on the circumference of the inner part 17 and/or biased preferably in parallel and/or in axial direction into a locking position by one or more locking springs 67. This modification is not shown, but would allow very secure blocking in the locked state.
  • the proposed nebulizer 1 is preferably designed to be portable and in particular is a mobile hand operated device.
  • the proposed solution may, however, be used not only in the nebulizers 1 specifically described here but also in other nebulizers or inhalers, e.g. powder inhalers or so-called metered dose inhalers.
  • the fluid 2 is a liquid, as already mentioned, especially an aqueous pharmaceutical formulation or an ethanolic pharmaceutical formulation. However, it may also be some other pharmaceutical formulation, a suspension or the like.
  • the fluid 2 may also comprise particles or powder.
  • some other kind of supply device may be provided, especially an expulsion opening (not shown) or a supply channel (not shown) for supplying the fluid to or powder or the like into the mouthpiece 13.
  • the optional air supply opening 15 then serves to supply ambient air preferably in parallel so as to general or allow an airflow with a sufficient volume for breathing in or inhaling through the mouthpiece 13.
  • the fluid 2 may also be atomized by means of a propellant gas.
  • Preferred ingredients and/or formulations of the preferably medicinal fluid 2 are listed in particular in WO 2009/1 15200 A1 , preferably on pages 25 to 40, or in EP 2 614 848 A1 , paragraphs 0040 to 0087, which are incorporated herewith by reference.
  • these may be aqueous or non-aqueous solutions, mixtures, formulations containing ethanol or free from any solvent, or the like.
  • venting hole 63 control part
  • nebulizer housing 64 retaining nose

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Mechanical Engineering (AREA)
  • Physics & Mathematics (AREA)
  • Theoretical Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
  • Nozzles (AREA)
  • Details Of Rigid Or Semi-Rigid Containers (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Closures For Containers (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
PCT/EP2015/000900 2014-05-07 2015-05-04 Nebulizer WO2015169428A2 (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
US15/308,879 US10716907B2 (en) 2014-05-07 2015-05-04 Nebulizer
NZ724463A NZ724463B2 (en) 2014-05-07 2015-05-04 Nebulizer
ES15724938T ES2853775T3 (es) 2014-05-07 2015-05-04 Nebulizador
PL15724938T PL3139981T3 (pl) 2014-05-07 2015-05-04 Nebulizator
AU2015258107A AU2015258107B2 (en) 2014-05-07 2015-05-04 Nebulizer
MX2016014399A MX2016014399A (es) 2014-05-07 2015-05-04 Nebulizador.
DK15724938.4T DK3139981T3 (da) 2014-05-07 2015-05-04 Forstøver
BR112016023720-0A BR112016023720B1 (pt) 2014-05-07 2015-05-04 Nebulizador
KR1020167033120A KR102382358B1 (ko) 2014-05-07 2015-05-04 분무기
CA2948066A CA2948066C (en) 2014-05-07 2015-05-04 Nebulizer
JP2016566222A JP6643252B2 (ja) 2014-05-07 2015-05-04 ネブライザ
EP15724938.4A EP3139981B1 (en) 2014-05-07 2015-05-04 Nebulizer
CN201580022298.9A CN106232166B (zh) 2014-05-07 2015-05-04 喷雾器
EA201692239A EA032832B1 (ru) 2014-05-07 2015-05-04 Небулайзер
IL247926A IL247926B (en) 2014-05-07 2016-09-20 A device that turns a liquid into a fine spray
PH12016502190A PH12016502190A1 (en) 2014-05-07 2016-11-04 Nebulizer

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14001603.1 2014-05-07
EP14001603 2014-05-07

Publications (2)

Publication Number Publication Date
WO2015169428A2 true WO2015169428A2 (en) 2015-11-12
WO2015169428A3 WO2015169428A3 (en) 2015-12-30

Family

ID=50679834

Family Applications (4)

Application Number Title Priority Date Filing Date
PCT/EP2015/000903 WO2015169431A2 (en) 2014-05-07 2015-05-04 Nebulizer, indicator device and container
PCT/EP2015/000900 WO2015169428A2 (en) 2014-05-07 2015-05-04 Nebulizer
PCT/EP2015/059740 WO2015169759A1 (en) 2014-05-07 2015-05-04 Nebulizer and container
PCT/EP2015/000901 WO2015169429A2 (en) 2014-05-07 2015-05-04 Container, indicator device, and nebulizer

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/EP2015/000903 WO2015169431A2 (en) 2014-05-07 2015-05-04 Nebulizer, indicator device and container

Family Applications After (2)

Application Number Title Priority Date Filing Date
PCT/EP2015/059740 WO2015169759A1 (en) 2014-05-07 2015-05-04 Nebulizer and container
PCT/EP2015/000901 WO2015169429A2 (en) 2014-05-07 2015-05-04 Container, indicator device, and nebulizer

Country Status (33)

Country Link
US (4) US10716907B2 (ko)
EP (7) EP3139980A1 (ko)
JP (5) JP6745225B2 (ko)
KR (5) KR102492824B1 (ko)
CN (6) CN116036425A (ko)
AP (1) AP2016009486A0 (ko)
AR (2) AR100963A1 (ko)
AU (6) AU2015258110B2 (ko)
BR (5) BR112016023719B1 (ko)
CA (4) CA2945018C (ko)
CL (5) CL2016002801A1 (ko)
DK (4) DK3139982T3 (ko)
EA (5) EA035261B1 (ko)
ES (4) ES2957901T3 (ko)
FI (1) FI3928818T3 (ko)
HR (2) HRP20230370T1 (ko)
HU (4) HUE058904T2 (ko)
IL (4) IL247928B (ko)
LT (2) LT3139982T (ko)
MX (5) MX2016014403A (ko)
MY (1) MY187485A (ko)
NZ (2) NZ724449A (ko)
PE (2) PE20210959A1 (ko)
PH (5) PH12016502192B1 (ko)
PL (4) PL3139981T3 (ko)
PT (3) PT3139979T (ko)
RS (2) RS63171B1 (ko)
SG (2) SG11201608891RA (ko)
SI (2) SI3139982T1 (ko)
TW (1) TWI607770B (ko)
UA (1) UA121114C2 (ko)
UY (1) UY36115A (ko)
WO (4) WO2015169431A2 (ko)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10716907B2 (en) 2014-05-07 2020-07-21 Boehringer Ingelheim International Gmbh Nebulizer
WO2024209239A1 (en) 2023-04-06 2024-10-10 Neutec Inhaler Ilac Sanayi Ve Ticaret Anonim Sirketi Nebulizer and container for a nebulizer

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2077132A1 (en) 2008-01-02 2009-07-08 Boehringer Ingelheim Pharma GmbH & Co. KG Dispensing device, storage device and method for dispensing a formulation
WO2010112358A2 (de) 2009-03-31 2010-10-07 Boehringer Ingelheim International Gmbh Verfahren zur beschichtung einer oberfläche eines bauteils
JP5763053B2 (ja) 2009-05-18 2015-08-12 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング アダプタ、吸入器具及びアトマイザ
US10016568B2 (en) 2009-11-25 2018-07-10 Boehringer Ingelheim International Gmbh Nebulizer
EA026241B1 (ru) 2009-11-25 2017-03-31 Бёрингер Ингельхайм Интернациональ Гмбх Распылитель
JP5658268B2 (ja) 2009-11-25 2015-01-21 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ネブライザ
JP5874724B2 (ja) 2010-06-24 2016-03-02 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ネブライザ
WO2012130757A1 (de) 2011-04-01 2012-10-04 Boehringer Ingelheim International Gmbh Medizinisches gerät mit behälter
US9827384B2 (en) 2011-05-23 2017-11-28 Boehringer Ingelheim International Gmbh Nebulizer
WO2013152894A1 (de) 2012-04-13 2013-10-17 Boehringer Ingelheim International Gmbh Zerstäuber mit kodiermitteln
EP2835146B1 (en) 2013-08-09 2020-09-30 Boehringer Ingelheim International GmbH Nebulizer
US9744313B2 (en) 2013-08-09 2017-08-29 Boehringer Ingelheim International Gmbh Nebulizer
EP3139984B1 (en) 2014-05-07 2021-04-28 Boehringer Ingelheim International GmbH Nebulizer
DK3139979T3 (da) 2014-05-07 2023-10-09 Boehringer Ingelheim Int Enhed, forstøver og fremgangsmåde
JP6900372B2 (ja) 2015-11-09 2021-07-07 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ネブライザ及び容器
DE102015120949A1 (de) * 2015-12-02 2017-06-08 Alfred Von Schuckmann Inhalator für pulverförmige Substanzen sowie Zählwerk für einen Inhalator
DE102015120948A1 (de) * 2015-12-02 2017-06-08 Alfred Von Schuckmann Handgerät zur Ausgabe einer pharmazeutischen Substanz sowie Zählwerk und Schraubkappe für ein solches Handgerät
GB201605102D0 (en) 2016-03-24 2016-05-11 Nicoventures Holdings Ltd Mechanical connector for electronic vapour provision system
CN109259332B (zh) * 2016-05-06 2021-06-25 卓尔悦欧洲控股有限公司 雾化装置及带有该雾化装置的电子烟
US11369760B2 (en) * 2016-08-24 2022-06-28 Anovent Pharmaceutical (U.S.), Llc Inhalation atomizer comprising a blocking function and a counter
JP6733442B2 (ja) * 2016-09-08 2020-07-29 オムロンヘルスケア株式会社 メッシュ式ネブライザ
EA038372B1 (ru) 2016-12-21 2021-08-17 Бёрингер Ингельхайм Интернациональ Гмбх Ингалятор и картридж
DE102017100012A1 (de) * 2017-01-02 2018-07-05 Nebu-Tec Med. Produkte Eike Kern Gmbh Verneblereinheit mit direkt anschließbarer Ampulle
US10556072B2 (en) * 2017-01-31 2020-02-11 Dunan Microstaq, Inc. Metering device for a metered dose inhaler
WO2018172293A1 (en) * 2017-03-20 2018-09-27 Vectura Delivery Devices Limited Container for cleaning the membrane of a nebulizer
SG11201908683XA (en) * 2017-03-20 2019-10-30 Vectura Delivery Devices Ltd Method and container for cleaning the membrane of a nebulizer
KR20200032723A (ko) * 2017-07-21 2020-03-26 베링거 인겔하임 인터내셔날 게엠베하 분무기
CN115646681A (zh) * 2017-07-21 2023-01-31 勃林格殷格翰国际有限公司 喷雾器和储器
US20190054260A1 (en) * 2017-08-17 2019-02-21 Monzano Group LLC Nebulizer devices and methods
US10370176B2 (en) 2017-09-12 2019-08-06 Wd-40 Company Child resistant aerosol actuator
CN108041008B (zh) * 2017-12-08 2020-11-27 台州市协丰机械有限公司 一种电动喷雾器及其壳体安装结构
EP3727532B1 (de) * 2017-12-18 2022-10-12 Boehringer Ingelheim International GmbH Vorrichtung zum versetzen eines inhalators in einen auslösebereiten zustand
EP3501582B1 (en) * 2017-12-21 2022-04-27 Boehringer Ingelheim International GmbH Nebulizer and cartridge
DK3727533T3 (da) 2017-12-22 2023-02-06 Softhale Nv Blokeringsanordning
US20210268213A1 (en) 2018-06-15 2021-09-02 Boehringer Ingelheim International Gmbh System, cartridge and process
US10421086B1 (en) * 2018-06-19 2019-09-24 Christine Kuligowski Reusable dry erase spray paint can
KR102581573B1 (ko) * 2018-09-27 2023-09-25 에스에이치엘 메디컬 아게 에어로졸 디스펜서용 활성화 메커니즘
CN111135403A (zh) * 2018-11-02 2020-05-12 正大天晴药业集团股份有限公司 胶囊型干粉吸入器
CN111195382B (zh) * 2018-11-16 2022-04-19 微邦科技股份有限公司 雾化给药装置的锁定结构
EP3886954A4 (en) * 2018-11-30 2022-09-07 Noble International, Inc. TRAINING DEVICE FOR INHALATION CARTRIDGE PLACEMENT
CA3135437C (en) * 2019-04-01 2023-09-12 Ppg Architectural Finishes, Inc. Pneumatic material spray gun cartridge tip assemblies
US20210030978A1 (en) * 2019-07-29 2021-02-04 Cai Gu Huang Cartridge with single-layer container and its nozzle-shaped cap for nebulization inhalation
TWM620483U (zh) * 2020-06-30 2021-12-01 微邦科技股份有限公司 噴霧器及儲存裝置
CN115835897A (zh) 2020-07-03 2023-03-21 勃林格殷格翰国际有限公司 喷雾器
CN113967299A (zh) * 2020-07-22 2022-01-25 苏州天健云康信息科技有限公司 雾化装置以及用于雾化装置的计数模块
GB2626538A (en) * 2023-01-24 2024-07-31 Merxin Ltd Cartridge
CN117180564B (zh) * 2023-07-24 2024-04-19 齐鲁制药有限公司 一种带锁定机构的计数器和包含计数器的喷雾器
CN117205412B (zh) * 2023-11-07 2024-02-13 正大天晴(广州)医药有限公司 剂量指示装置

Family Cites Families (608)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6199766B1 (en) 1909-03-29 2001-03-13 University Of Southampton Targeting of flying insects with insecticides and apparatus for charging liquids
US1828864A (en) 1923-02-20 1931-10-27 Gilmont Products Corp Method of filling bicompartment collapsible tubes
GB414953A (en) 1932-12-24 1934-08-16 Josef Schoene Medical injection syringe
US2127401A (en) 1937-11-15 1938-08-16 Gillican Charles Crum Method of packaging rosin
US2161071A (en) 1938-05-02 1939-06-06 Zellerbach Paper Company Method of packing frozen food
US2321428A (en) 1939-04-25 1943-06-08 Ferdinand G Schloz Nozzle
US2329311A (en) 1940-06-05 1943-09-14 Harry F Waters Method of producing liquid-containing packages
US2362103A (en) 1941-01-04 1944-11-07 Arthur E Smith Ampoule
US2651303A (en) 1948-11-13 1953-09-08 Richard S Johnson Inhaler
US2720969A (en) 1953-12-10 1955-10-18 Becton Dickinson Co Package and mounting for hypodermic syringe assembly
DK83175C (da) 1955-07-04 1957-07-22 Grosserer Gorm Tage Hansen Luftreguleringsanlæg til drivhuse.
US2974880A (en) 1955-11-15 1961-03-14 Drackett Co Aerosol spray head
US2793776A (en) 1956-05-23 1957-05-28 Lipari Michael Container attachment for providing a compartmental dispensing receptacle
US3172568A (en) 1959-03-27 1965-03-09 Modern Lab Inc Pressurized dispensing device
US3032823A (en) 1960-05-26 1962-05-08 Sherman Plastics Corp Method of forming plastic articles
GB951228A (en) 1961-09-26 1964-03-04 Ici Ltd Packaging process
FR1314002A (fr) 1961-11-24 1963-01-04 Procédé et dispositif pour distribuer une substance non compacte
US3299603A (en) 1962-03-12 1967-01-24 Continental Can Co Method of filling pouches
NL297349A (ko) 1962-08-31
US3354883A (en) 1965-03-08 1967-11-28 Southerland Elizabeth Lee Disposable syringe having frangible means for mixing plural medicaments
US3440144A (en) 1965-05-21 1969-04-22 Andersen Prod H W Method and apparatus for checking and testing the effectiveness of sterilization
US3457694A (en) 1966-08-25 1969-07-29 Hideo Tatibana Method of and apparatus for fusion sealing the opening of flexible plastic bottle-like containers
US3491803A (en) 1966-10-03 1970-01-27 Haskon Inc Machine for filling with liquids containers having deformable side walls
FR1502925A (fr) 1966-10-12 1967-11-24 Vaporisateurs Marcel Franck Perfectionnements apportés aux pompes à piston pour la distribution de liquides ou pâtes fluides
GB1230472A (ko) 1967-07-10 1971-05-05
US3590557A (en) 1968-03-07 1971-07-06 Fr Hesser Maschinenfabrick Ag Apparatus for closing packaging containers with elastically deformable walls
US3580249A (en) 1968-09-16 1971-05-25 Kentaro Takaoka Aerosol nebulizers
US3674028A (en) 1969-06-04 1972-07-04 Ims Ltd Multi-mix
US3858580A (en) * 1969-06-04 1975-01-07 Ims Ltd Intravenous container mixing assembly
BE751383R (fr) 1969-08-12 1970-12-03 Oreal Valve perfectionnee pour recipient pressurise distributeur de plusieursproduits
US3655096A (en) 1969-10-22 1972-04-11 Pillsbury Co Container for diluting and dispensing material
US3949751A (en) 1970-03-03 1976-04-13 Fisons Limited Method and device for dispensing medicament to the body
US3674060A (en) 1970-12-14 1972-07-04 Continental Can Co Apparatus for filling and adjusting the contents level in flexible containers
BE788194A (fr) 1971-08-31 1973-02-28 Thomae Gmbh Dr K Dispositif pour l'administration de quantites mecaniquement dosees de medicaments liquides ou en solution
US3861851A (en) 1971-12-08 1975-01-21 Schiemann Dr Wolfram Apparatus for moulding the neck of an extruded hollow body
US3802604A (en) 1972-02-28 1974-04-09 Oreal Device for storing two products separately and dispensing them simultaneously
DE2221101C3 (de) 1972-04-28 1975-05-15 Wolf-Geraete Gmbh, 5240 Betzdorf Flaschenartiger Mischbehälter
US3933279A (en) 1972-11-28 1976-01-20 Ciba-Geigy Corporation Aerosol dispenser for fluid products comprising a piston pump assembly for generating compressed air
US3946732A (en) 1973-08-08 1976-03-30 Ampoules, Inc. Two-chamber mixing syringe
US3951310A (en) 1974-02-11 1976-04-20 V.C.A. Corporation Spring-charged aerosol dispenser
US3973603A (en) 1974-06-18 1976-08-10 Franz Henry H Control for filling flexible bottles or containers
DK140801B (da) 1975-01-15 1979-11-19 Nordisk Insulinlab Fremgangsmåde til fremstilling af et stabilt langtidsvirkende insulinpræparat.
US3924741A (en) 1975-03-04 1975-12-09 Gibson Ass Inc Two-compartment container
US3953995A (en) 1975-05-27 1976-05-04 Haswell John W Means for making double groove pulleys
US4153689A (en) 1975-06-13 1979-05-08 Takeda Chemical Industries, Ltd. Stable insulin preparation for nasal administration
US4012472A (en) 1975-07-17 1977-03-15 Arbrook, Inc. Medical fluids container
US4174035A (en) 1975-09-04 1979-11-13 Georg Wiegner Two-component container and package
US4036439A (en) 1975-09-24 1977-07-19 Newman-Green, Inc. Spray head for nebulization of fluids
US4067499A (en) 1976-02-17 1978-01-10 Cohen Milton J Non-aerosol continuous spray dispenser
US4126559A (en) 1976-03-30 1978-11-21 Pall Corporation Pharmaceutical filter
US4094317A (en) 1976-06-11 1978-06-13 Wasnich Richard D Nebulization system
US4048997A (en) 1976-11-01 1977-09-20 Mpl, Inc. Syringe with actinic radiation protection
US4099049A (en) * 1976-11-10 1978-07-04 Pitney-Bowes, Inc. Ascending register lockout system for a postage meter
IT1075249B (it) 1976-12-10 1985-04-22 Ottina Luigi Dispositivo a due contenitori per la conservazione indipendente di due componenti e la preparazione estemporanea di un prodotto con detti due componenti
US4177938A (en) 1977-06-30 1979-12-11 Brina Guido J Container with mixing cartridge
US4178928A (en) 1977-08-10 1979-12-18 Tischlinger Edward A Self injector
US4245788A (en) 1978-03-20 1981-01-20 Wright Hershel E Dispensing device for fluid material
US4195730A (en) 1978-06-20 1980-04-01 General Foods Corporation Container having separate storage facilities for two materials
CA1097276A (en) 1978-12-15 1981-03-10 Marcel J. H. Staar Package for storing and spraying small amounts of liquids
US4315570A (en) 1979-01-04 1982-02-16 Jules Silver Two-compartment container with means for dispersing contents of one compartment into the other compartment
JPS5819535B2 (ja) 1979-04-16 1983-04-19 本州製紙株式会社 密封容器のシ−ル方法
EP0018609B1 (de) 1979-04-30 1983-09-21 Hoechst Aktiengesellschaft Gegen Denaturierung beständige, wässrige Protein-Lösungen, Verfahren zu ihrer Herstellung und ihre Verwendung
DK374579A (da) 1979-09-07 1981-03-08 Nordisk Insulinlab Fremgangsmaade til fremstilling af et injucerbart insulinpraeparat
JPS5684246A (en) 1979-11-28 1981-07-09 Toppan Printing Co Ltd Vessel
US4377106A (en) 1980-06-30 1983-03-22 Realex Corporation Tamper-resistant locking clip for dispensing pumps
GB2083382B (en) 1980-09-08 1984-06-20 Metal Box Co Ltd Forming can bodies
DE3118783C2 (de) 1981-05-12 1986-02-20 Cantec, Inc., Fort Worth, Tex. Vorrichtung zum Sicken des Rumpfes eines Blechgebindes
AU558474B2 (en) 1981-07-17 1987-01-29 Nordisk Insulinlaboratorium A stable aqueous, therapeutic insulin preparation and a process for preparing it
US4516967A (en) 1981-12-21 1985-05-14 Kopfer Rudolph J Wet-dry compartmental syringe
WO1983003054A1 (en) 1982-03-03 1983-09-15 Johansen, Kristian, Betton A proces for producing an insulin preparation
GB2123481B (en) 1982-06-19 1985-04-17 Lucas Ind Plc C i engine fuel injection nozzles
US4456016A (en) 1982-07-01 1984-06-26 Trutek Research, Inc. Inhalation valve
US4515586A (en) 1982-11-30 1985-05-07 Abbott Laboratories Powder syringe mixing system
US4476116A (en) 1982-12-10 1984-10-09 Syntex (U.S.A.) Inc. Polypeptides/chelating agent nasal compositions having enhanced peptide absorption
USRE33444E (en) 1984-01-09 1990-11-20 Fluid treating for removal of components or for transfer of heat, momentum-apparatus and method
NZ209900A (en) 1984-10-16 1989-08-29 Univ Auckland Automatic inhaler
US4964540A (en) 1984-10-17 1990-10-23 Exxel Container, Inc. Pressurized fluid dispenser and method of making the same
EP0386800A1 (en) 1985-03-20 1990-09-12 Turbo Tek Enterprises, Inc. Spraying device having controlled additive fluid feed and a telescoping spray tube assembly
US4858830A (en) 1985-03-20 1989-08-22 Turbo Tek Enterprises, Inc. Spraying device having an additive fluid dispenser at an exit end
US4682734A (en) 1985-03-20 1987-07-28 Turbo Tek Enterprises, Inc. Spraying device having controlled additive fluid feed and a telescoping spray tube assembly
US4603794A (en) 1985-03-29 1986-08-05 Battelle Development Corporation Pressure multiplying dispenser
IT1185850B (it) 1985-08-02 1987-11-18 Zambon Spa Tappo serbatoio contagocce per flaconi
JPS6274364A (ja) 1985-09-27 1987-04-06 株式会社　ニツシヨ− 医療用具
US4727985A (en) 1986-02-24 1988-03-01 The Boc Group, Inc. Mixing and dispensing apparatus
JP2573275B2 (ja) 1986-03-10 1997-01-22 ブルグハルト，クルト 薬学的製剤及びその製造法
DE3611690A1 (de) 1986-04-08 1987-10-15 Pfeiffer Erich Gmbh & Co Kg Austragvorrichtung fuer mischmedien
DK179286D0 (da) 1986-04-18 1986-04-18 Nordisk Gentofte Insulinpraeparat
US4749082A (en) 1986-05-05 1988-06-07 Imperial Schrade Corp. Knife transport/display package
FR2604363A1 (fr) 1986-09-30 1988-04-01 Merieux Inst Dispositif d'injection de substances, notamment medicamenteuses
FI89458C (fi) 1986-11-06 1993-10-11 Leiras Oy Inhaleringsanordning
US4796614A (en) 1987-02-26 1989-01-10 Trutek Research, Inc. Collapsible inhalation valve
US4952310A (en) 1987-03-03 1990-08-28 Mcmahan Anthony A Intrachannel clarifier
GB8710067D0 (en) 1987-04-28 1987-06-03 British Telecomm Optical device
JP2656944B2 (ja) 1987-04-30 1997-09-24 クーパー ラボラトリーズ タンパク質性治療剤のエアロゾール化
DE3721308A1 (de) 1987-06-27 1989-01-05 Gerhard Hansen Verfahren zum befuellen und anschliessenden verschweissen eines behaelters sowie vorrichtung und behaelter zur durchfuehrung dieses verfahrens
US4840017A (en) 1987-08-03 1989-06-20 Baxter Healthcare Corporation Method for filling collapsible containers
DE3729206A1 (de) 1987-08-28 1989-03-09 Siemens Ag Verfahren zum ausbilden von tintenkanaelen in einem schreibkopf fuer eine tintenmosaikschreibeinrichtung
PT88490B (pt) 1987-09-14 1992-11-30 Novo Nordisk As Processo para a preparacao de composicoes farmaceuticas para libertacao nao-enterica trans-mucosa contendo monossacaridos ou oligossacaridos
FR2621818B1 (fr) 1987-10-19 1990-12-14 Medipro Medicament comprenant l'association de polymixine b, de netilmicine et d'amphotericine b administre par vaporisation
FR2621817B1 (fr) 1987-10-19 1990-12-14 Medipro Medicament comprenant l'association de polymyxine b, de tobramycine et d'amphotericine b administre par vaporisation
FR2624015B1 (fr) 1987-12-03 1990-06-29 Medipro Medicament comprenant l'association de colistine, de tobramycine et d'amphotericine b administre par vaporisation
US5067655A (en) 1987-12-11 1991-11-26 Deutsche Forschungsanstalt Fuer Luft- Und Raumfahrt Whirl nozzle for atomizing a liquid
US4805377A (en) 1987-12-23 1989-02-21 Entravision, Inc. Method of packaging and sterilizing a pharmaceutical product
DE3837595A1 (de) 1988-04-14 1990-05-10 Goldwell Gmbh Doppelkammer-behaelter
US4951661A (en) 1988-06-08 1990-08-28 Thayer Medical Corporation Quick-connect adapter valve for connecting nebulizer and fluid ventilator hose
JP2720899B2 (ja) 1988-07-15 1998-03-04 合資会社ミノファーゲン製薬本舗 経粘膜吸収促進剤及びこれを用いた経鼻投与剤
DE3827121A1 (de) 1988-08-10 1990-02-15 Hoechst Ag Verfahren zur herstellung von des-b30-insulinen und des-b30-insulinderivaten
US5025957A (en) 1988-10-07 1991-06-25 Ryder International Corp. Liquid dispenser nozzle assembly
DE3834184C1 (ko) 1988-10-07 1989-12-28 Bernd 7166 Sulzbach-Laufen De Hansen
JPH02104531A (ja) 1988-10-14 1990-04-17 Toyo Jozo Co Ltd 経鼻投与用生理活性ペプチド組成物
US5059187A (en) 1988-11-30 1991-10-22 Dey Laboratories, Inc. Method for the cleansing of wounds using an aerosol container having liquid wound cleansing solution
FR2639903B1 (fr) 1988-12-05 1991-05-10 Cebal Procede et dispositif de fermeture d'un tube souple apres remplissage
GB8828477D0 (en) 1988-12-06 1989-01-05 Riker Laboratories Inc Medical aerosol formulations
CA2006582A1 (fr) 1988-12-27 1990-06-27 Gabriel Meyer Flacon de stockage et de transfert concu pour stocker deux composants dune substance medicamenteuse
US5129550A (en) 1989-01-23 1992-07-14 Battelle Memorial Institute Spray bottle apparatus with force multiply pistons
US5718355A (en) * 1989-02-03 1998-02-17 Senetics, Inc. Indicator device responsive to axial force for use with inhaler
CA2050905A1 (en) 1989-02-23 1990-08-24 George R. Felt Therapeutic aerosol formulations
GB8904370D0 (en) 1989-02-25 1989-04-12 Cosmas Damian Ltd Liquid delivery compositions
JP2922935B2 (ja) 1989-08-11 1999-07-26 東興薬品工業株式会社 粘稠液用鼻孔内噴霧容器の使捨てアダプタ
FR2653744B1 (fr) 1989-10-31 1992-03-06 Valois Procede pour conditionner sous vide des produits notamment cosmetiques et pharmaceutiques a l'interieur de reservoirs deformables obtures par une pompe de distribution sans reprise d'air, dispositif pour le mettre en óoeuvre et distributeurs ainsi obt.
US4979941A (en) 1989-12-05 1990-12-25 International Medication Systems, Limited Device suitable for mixing medication
SK280967B6 (sk) 1990-03-02 2000-10-09 Glaxo Group Limited Inhalačný prístroj
SG45171A1 (en) 1990-03-21 1998-01-16 Boehringer Ingelheim Int Atomising devices and methods
IT1243344B (it) 1990-07-16 1994-06-10 Promo Pack Sa Inalatore plurimonodose per medicamenti in polvere
DE4027320C2 (de) 1990-08-29 1993-09-30 Ursapharm Arzneimittel Gmbh Fluid-Abgabeeinrichtung für keimfreies Fluid
US5230884A (en) 1990-09-11 1993-07-27 University Of Wales College Of Cardiff Aerosol formulations including proteins and peptides solubilized in reverse micelles and process for making the aerosol formulations
IL99699A (en) 1990-10-10 2002-04-21 Autoimmune Inc Drug with the option of oral, intra-intestinal, or inhaled dosing for suppression of autoimmune response associated with type I diabetes
JPH04177092A (ja) 1990-11-08 1992-06-24 Toshiba Corp 熱交換器およびその製造方法
GB9024760D0 (en) 1990-11-14 1991-01-02 Riker Laboratories Inc Inhalation device and medicament carrier
US5352196A (en) 1990-11-19 1994-10-04 Habley Medical Technology Corporation Mixing vial
GB9025654D0 (en) * 1990-11-26 1991-01-09 Riker Laboratories Inc Device
WO1992011050A1 (en) 1990-12-17 1992-07-09 Minnesota Mining And Manufacturing Company Inhaler
EP0683890B1 (en) 1991-03-05 2002-04-03 Aradigm Corporation Method and device for correcting the drift offset of a pressure sensor of a flowmeter
US5394866A (en) 1991-03-05 1995-03-07 Aradigm Corporation Automatic aerosol medication delivery system and methods
FR2673608A1 (fr) 1991-03-07 1992-09-11 Chanel Distributeur de produit comprenant des moyens d'inviolabilite.
AU643141B2 (en) 1991-03-15 1993-11-04 Amgen, Inc. Pulmonary administration of granulocyte colony stimulating factor
WO1992017231A1 (en) 1991-03-28 1992-10-15 Innomed, Inc. Microelectronic inhaler having a counter and timer
US5156918A (en) 1991-03-28 1992-10-20 Northwestern University Self-assembled super lattices
IT223172Z2 (it) 1991-04-09 1995-06-13 Tecnomedica Ricerche Srl Dispositivo per la somministrazione di farmaci, particolarmente farma-ci a due componenti
AU651882B2 (en) 1991-05-14 1994-08-04 Visiomed Group Limited Aerosol inhalation device
DE4117078A1 (de) 1991-05-25 1992-11-26 Boehringer Ingelheim Kg Verfahren zur herstellung therapeutisch anwendbarer aerosole
WO1992022286A1 (en) 1991-06-12 1992-12-23 Minnesota Mining And Manufacturing Company Albuterol sulfate suspension aerosol formulations
JPH057246A (ja) 1991-06-27 1993-01-14 Fujitsu Ltd キヤンプオンサービス通信方式
EP0520571B1 (en) 1991-06-28 1998-09-09 Weston Medical Limited Atomising nozzle
US5222385A (en) 1991-07-24 1993-06-29 American National Can Company Method and apparatus for reforming can bottom to provide improved strength
EP0526393B1 (de) 1991-07-30 1996-08-28 Sulzer Chemtech AG Einmischvorrichtung
JPH0553470A (ja) 1991-08-29 1993-03-05 Ricoh Co Ltd 定着ユニツト
US5246142A (en) 1991-09-26 1993-09-21 Dipalma Elio Device for storing two products separately and subsequently mixing them
US5456522A (en) 1991-10-14 1995-10-10 Kennametal Inc. Concave cutter bit
ES2088263T3 (es) 1992-01-21 1996-08-01 Medicorp Holding Dispositivo de almacenamiento de una sustancia medicamentosa liquida y de distribucion de gotas oftalmicas.
US5282549A (en) 1992-03-16 1994-02-01 Williams Dispenser Corporation Dispenser with an energy storage member and an overload prevention mechanism
US5263842A (en) 1992-03-30 1993-11-23 Stanley-Bostitch, Inc. Nail driver with improved nosepiece assembly
SE9201718D0 (sv) 1992-06-03 1992-06-03 Astra Ab Nasal spray device
US5271153A (en) 1992-06-11 1993-12-21 The Procter & Gamble Company Apparatus for assembling a thin film beam spring vent valve
AU4384093A (en) 1992-06-11 1994-01-04 Procter & Gamble Company, The Thin film beam spring vent valve and method and apparatus for assembling it
US5261565A (en) 1992-06-11 1993-11-16 The Procter & Gamble Company Thin film beam spring vent valve
CA2097866A1 (en) 1992-06-11 1993-12-12 Howard Norman Reiboldt Method and apparatus for assembling a thin film beam spring vent valve
US5284133A (en) 1992-07-23 1994-02-08 Armstrong Pharmaceuticals, Inc. Inhalation device with a dose-timer, an actuator mechanism, and patient compliance monitoring means
GB2273660B (en) 1992-09-11 1996-07-17 Aid Medic Ltd Drug delivery arrangement
IL107120A (en) 1992-09-29 1997-09-30 Boehringer Ingelheim Int Atomising nozzle and filter and spray generating device
US6007676A (en) 1992-09-29 1999-12-28 Boehringer Ingelheim International Gmbh Atomizing nozzle and filter and spray generating device
DE4237568C1 (de) 1992-11-06 1994-05-11 Dieter Dipl Ing Dr Med Koehler Verfahren und Vorrichtung zum Erzeugen eines Aerosols
US5339990A (en) 1992-11-10 1994-08-23 Wilder Robert E Adjustable pump dispenser
ATE177941T1 (de) 1992-12-09 1999-04-15 Boehringer Ingelheim Pharma Stabilisierte medizinische aerosollösungen
ES2115201T3 (es) 1992-12-15 1998-06-16 Sanofi Sa Dispositivo para la preparacion de una solucion, de una suspension o de una emulsion de una sustancia medicinal.
US5888477A (en) 1993-01-29 1999-03-30 Aradigm Corporation Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin
US5934272A (en) 1993-01-29 1999-08-10 Aradigm Corporation Device and method of creating aerosolized mist of respiratory drug
AU685433B2 (en) 1993-02-12 1998-01-22 Regents Of The University Of Minnesota Pulmonary administration of sCR1 and other complement inhibitory proteins
US5399159A (en) 1993-03-30 1995-03-21 Origin Medsystems, Inc. Apparatus and method for hand-held insufflation
DE69406916T2 (de) 1993-04-30 1998-06-25 Minnesota Mining And Mfg. Co., Saint Paul, Minn. Abdichtung an aerosolbehältern
JPH06312019A (ja) 1993-04-30 1994-11-08 Shinko Kagaku Kk 薬液噴霧容器
US6062430A (en) 1993-05-05 2000-05-16 Ing. Erich Pfeiffer Gmbh Dispensing container with variable volume compensation
US5709202A (en) 1993-05-21 1998-01-20 Aradigm Corporation Intrapulmonary delivery of aerosolized formulations
US5497763A (en) 1993-05-21 1996-03-12 Aradigm Corporation Disposable package for intrapulmonary delivery of aerosolized formulations
WO1994027729A1 (de) 1993-05-25 1994-12-08 Winfried Werding Spritzdüse für die regulierung der durchflussmenge pro zeiteinheit
GB9312984D0 (en) 1993-06-23 1993-08-04 Bespak Plc Atomising dispenser
NZ271181A (en) 1993-07-19 1998-06-26 Amgen Inc Protein protection; method for stabilising aerosolised proteins by adding a water-soluble polar organic compound to the aqueous solution prior to aerosolisation
US5433343A (en) 1993-07-30 1995-07-18 Meshberg; Philip Delivery system for measured quantities of liquids, especially medications
US6596260B1 (en) 1993-08-27 2003-07-22 Novartis Corporation Aerosol container and a method for storage and administration of a predetermined amount of a pharmaceutically active aerosol
DE69412492T2 (de) 1993-09-07 1999-02-11 Debiotech S.A., Lausanne Spritzenvorrichtung zum mischen von zwei präparaten
US5435884A (en) 1993-09-30 1995-07-25 Parker-Hannifin Corporation Spray nozzle and method of manufacturing same
JPH07118164A (ja) 1993-10-19 1995-05-09 Dot:Kk 経鼻吸収薬物用キャリヤおよび生理活性ペプチド組成物
JPH07118166A (ja) 1993-10-19 1995-05-09 Dot:Kk インシュリン組成物
JPH07165613A (ja) 1993-10-19 1995-06-27 Dot:Kk 経鼻吸収薬物用キャリヤおよび生理活性ペプチド組成物
JP2957154B2 (ja) 1997-11-18 1999-10-04 株式会社三五 管端の成形方法とその装置
US5518147A (en) 1994-03-01 1996-05-21 The Procter & Gamble Company Collapsible pump chamber having predetermined collapsing pattern
US6051256A (en) 1994-03-07 2000-04-18 Inhale Therapeutic Systems Dispersible macromolecule compositions and methods for their preparation and use
SE9401220D0 (sv) 1994-04-11 1994-04-11 Astra Ab Valve
US5451569A (en) 1994-04-19 1995-09-19 Hong Kong University Of Science And Technology R & D Corporation Limited Pulmonary drug delivery system
GB9408276D0 (en) 1994-04-26 1994-06-15 Bespak Plc Dispensing pump
GB9420971D0 (en) 1994-05-06 1994-12-07 Minnesota Mining & Mfg Aerosol valves
JP3414539B2 (ja) 1994-05-11 2003-06-09 有限会社ドット 経鼻吸収用組成物
US5435282A (en) 1994-05-19 1995-07-25 Habley Medical Technology Corporation Nebulizer
US5848588A (en) 1994-05-25 1998-12-15 Trudell Medical Group Backpiece for receiving an MDI adapter in an aerosolization spacer
KR960704591A (ko) 1994-05-25 1996-10-09 메이어 가브리엘 의학 물질의 용액, 현탁액 또는 에멀션의 제제를 위한 장치(device for the preparation fo a solution. a suspension or an emulsion of a medicinal substance)
US5564414A (en) * 1994-05-26 1996-10-15 Walker; William F. Pressurized and metered medication dose counter on removable sleeve
JP2930526B2 (ja) 1994-05-31 1999-08-03 株式会社キートロン インジェクター型アトマイザー
JPH07323086A (ja) 1994-06-01 1995-12-12 Matsushita Seiko Co Ltd 吸入器
US5482030A (en) 1994-06-13 1996-01-09 Klein; David Aerosol and non-aerosol spray counter
WO1996000050A1 (en) 1994-06-23 1996-01-04 R.P. Scherer Corporation Ocular treatment device
GB2291135B (en) 1994-07-06 1998-02-25 Boehringer Ingelheim Kg Device for dispensing fluid
US5509404A (en) 1994-07-11 1996-04-23 Aradigm Corporation Intrapulmonary drug delivery within therapeutically relevant inspiratory flow/volume values
DE4428434A1 (de) 1994-08-11 1996-02-15 Boehringer Ingelheim Kg Verschlußkappe und Verfahren zur gasblasenfreien Füllung von Behältern
WO1996006581A1 (en) 1994-08-30 1996-03-07 R.P. Scherer Limited Ocular treatment device
JP3706136B2 (ja) 1994-09-21 2005-10-12 ネクター セラピューティクス 乾燥粉末薬剤の分散装置及び方法
US5503869A (en) 1994-10-21 1996-04-02 Glaxo Wellcome Inc. Process for forming medicament carrier for dry powder inhalator
US5622163A (en) 1994-11-29 1997-04-22 Iep Group, Inc. Counter for fluid dispensers
WO1996019389A1 (fr) 1994-12-22 1996-06-27 Pentel Kabushiki Kaisha Conteneur de deversement
MX9704550A (es) 1994-12-22 1997-10-31 Astra Ab Formulaciones de medicamentos en aerosol.
US5499750A (en) 1995-01-17 1996-03-19 Manifold; William J. Spraying device having a removable and replaceable bladder
AUPN089295A0 (en) 1995-02-02 1995-03-02 International Diabetes Institute Treatment of diabetic neuropathy
JP2802488B2 (ja) 1995-02-08 1998-09-24 有限会社ドット 経鼻吸収用生理活性ペプチド組成物
US5685846A (en) 1995-02-27 1997-11-11 Schott Parenta Systems, Inc. Dual chamber internal by-pass syringe assembly
US5541569A (en) 1995-02-28 1996-07-30 Jang; Huey J. Switch having a circuit breaker
AR002976A1 (es) 1995-03-31 1998-05-27 Lilly Co Eli Formulaciones farmaceuticas parenterales de efecto prolongado de insulina; cristales de dichos analogos aplicables en dichas formulaciones yprocedimiento de las formulaciones mencionadas
US6427682B1 (en) 1995-04-05 2002-08-06 Aerogen, Inc. Methods and apparatus for aerosolizing a substance
TR199701167T1 (xx) 1995-04-14 1998-03-21 Glaxo Wellcome Inc. Albuterol i�in �l��lm�� doz inhaleri.
US6392962B1 (en) 1995-05-18 2002-05-21 Rmp, Inc. Method of sleep time measurement
JP3462934B2 (ja) 1995-06-19 2003-11-05 株式会社吉野工業所 合成樹脂製肉薄密封容器
DK0835098T3 (da) 1995-06-27 2002-10-07 Boehringer Ingelheim Pharma Stabilt lægemiddelpræparat til frembringlese af drivgasfrie aerosoler
US6209538B1 (en) 1995-08-02 2001-04-03 Robert A. Casper Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament
JPH11292787A (ja) 1995-08-15 1999-10-26 Asahi Chem Ind Co Ltd 生理活性ペプチドを含有する経粘膜投与製剤
EP0846011A1 (en) 1995-08-18 1998-06-10 Pharmasol Limited Spray applicator
GB9516984D0 (en) 1995-08-18 1995-10-18 Pharmasol Ltd Spray applicator
JPH0977073A (ja) 1995-09-19 1997-03-25 Yoshino Kogyosho Co Ltd 合成樹脂製肉薄密封容器
US5738087A (en) 1995-09-21 1998-04-14 King; Russell W. Aerosol medication delivery system
DE19536903C2 (de) 1995-10-04 1998-09-10 Boehringer Ingelheim Int Vorrichtung zum Haltern eines fluidischen Bauteils
DE19536902A1 (de) * 1995-10-04 1997-04-10 Boehringer Ingelheim Int Vorrichtung zur Hochdruckerzeugung in einem Fluid in Miniaturausführung
DE59610157D1 (de) 1995-11-17 2003-03-27 Ursatec Verpackung Gmbh Vor kontamination schützende abgabevorrichtung für fluide
ES2128220B1 (es) 1995-12-04 1999-12-16 Cusi Lab Envase farmaceutico de dos sustancias separadas, con dispositivo de mezcla, aplicacion dosificada y su proceso de montaje.
DE19545226C1 (de) 1995-12-05 1997-06-19 Boehringer Ingelheim Int Sperrspannwerk für einen federbetätigten Abtrieb
US7131441B1 (en) 1995-12-07 2006-11-07 Skyepharma Ag Inhaler for multiple dosed administration of a pharmacological dry powder
CN1209059A (zh) 1995-12-21 1999-02-24 基因实验室技术有限公司 紫杉烷类组合物及方法
DE19549033C1 (de) 1995-12-28 1997-05-28 Boehringer Ingelheim Int Mechanisches Zählwerk für ein Dosiergerät
CA2245079A1 (en) 1996-02-05 1997-08-07 Fred Silverstein Ventilation imaging using a fine particle aerosol generator
CN1118628C (zh) 1996-02-09 2003-08-20 威斯顿布里奇国际有限公司 用于微型泵的微加工过滤器
GB9606188D0 (en) 1996-03-23 1996-05-29 Danbiosyst Uk Pollysaccharide microspheres for the pulmonary delivery of drugs
DE19615422A1 (de) 1996-04-19 1997-11-20 Boehringer Ingelheim Kg Zweikammer-Kartusche für treibgasfreie Dosieraerosole
JPH09315953A (ja) 1996-05-28 1997-12-09 Dot:Kk 経鼻吸収用生理活性ペプチド組成物
GB2316323B (en) 1996-06-20 1999-09-22 Aid Medic Ltd Dispensing system
GB9619445D0 (en) 1996-09-18 1996-10-30 Boots Co Plc Fluid dispenser
JP3666537B2 (ja) 1996-11-14 2005-06-29 セイコーエプソン株式会社 インクジェット式記録装置用インクカートリッジの製造方法
FR2756546B1 (fr) 1996-11-29 1999-01-29 Valois Dispositif de fixation d'un organe de distribution sur un col de recipient
FR2756502B1 (fr) 1996-12-03 1999-01-22 Oreal Buse pour dispositif de pulverisation d'un liquide et dispositif de pulverisation equipe d'une telle buse
US20030215396A1 (en) 1999-09-15 2003-11-20 Boehringer Ingelheim Pharma Kg Method for the production of propellant gas-free aerosols from aqueous medicament preparations
US6259654B1 (en) 1997-03-28 2001-07-10 Telaric, L.L.C. Multi-vial medication organizer and dispenser
DE19653969A1 (de) 1996-12-20 1998-06-25 Boehringer Ingelheim Kg Neue wässrige Arzneimittelzubereitung zur Erzeugung treibgasfreier Aerosole
GB9626960D0 (en) 1996-12-27 1997-02-12 Glaxo Group Ltd Valve for aerosol container
ATE287257T1 (de) 1997-01-16 2005-02-15 Massachusetts Inst Technology Zubereitung von partikelhaltigen arzneimitteln zur inhalation
JP3940455B2 (ja) 1997-01-30 2007-07-04 武田薬品工業株式会社 ２室式容器兼用注射器
US5829435A (en) 1997-02-24 1998-11-03 Aradigm Corporation Prefilter for prevention of clogging of a nozzle in the generation of an aerosol and prevention of administration of undesirable particles
DE19708406A1 (de) 1997-03-03 1998-09-10 Alfred Von Schuckmann Gerät zur dosierten Ausgabe von Substanzen
SE9700936D0 (sv) 1997-03-14 1997-03-14 Astra Ab Inhalation device
US7978564B2 (en) 1997-03-28 2011-07-12 Carlos De La Huerga Interactive medication container
JPH1147274A (ja) 1997-06-03 1999-02-23 Takeda Chem Ind Ltd ２室型注射器及び２室型注射器用接続具
IT1293005B1 (it) 1997-06-10 1999-02-11 Bernardino Parise Contenitore per sostanze concentrate in polvere o liquide da porre in soluzione entro un involucro al momento dell'uso
KR100235460B1 (ko) 1997-06-25 1999-12-15 유무성 재활용 가능한 일회용 카메라
US6200181B1 (en) 1997-07-01 2001-03-13 Candescent Technologies Corporation Thermally conductive spacer materials and spacer attachment methods for thin cathode ray tube
JP2001524330A (ja) 1997-07-18 2001-12-04 バスカ， インコーポレイテッド 移植ポートに経皮的に接近するための方法および装置
EP0894511A3 (en) 1997-07-29 2001-02-07 Chino, Mitsumasa Dustproof mask
DE19733651A1 (de) 1997-08-04 1999-02-18 Boehringer Ingelheim Pharma Wässrige Aerosolzubereitungen enthaltend biologisch aktive Markomoleküle und Verfahren zur Erzeugung entsprechender Aerosole
US20060239930A1 (en) 1997-08-04 2006-10-26 Herbert Lamche Process for nebulizing aqueous compositions containing highly concentrated insulin
FR2767793B1 (fr) 1997-09-02 1999-11-19 Valois Sa Dispositif de distribution a bague de fixation a emmanchage conique
CA2303816C (en) 1997-09-04 2007-07-31 Heineken Technical Services B.V. Assembly for storing and dispensing beer and other carbonated beverages
DE19742559C2 (de) 1997-09-26 1999-08-05 Gaplast Gmbh Behälter mit Pumpe
DE19742439C1 (de) 1997-09-26 1998-10-22 Boehringer Ingelheim Int Mikrostrukturiertes Filter
US6458095B1 (en) 1997-10-22 2002-10-01 3M Innovative Properties Company Dispenser for an adhesive tissue sealant having a housing with multiple cavities
US6395331B1 (en) 1997-10-28 2002-05-28 Yazaki Corporation Transparent substrate bearing an anti-stain, hydrophobic coating, and process for making it
US5902298A (en) 1997-11-07 1999-05-11 Bracco Research Usa Medicament container stopper with integral spike access means
GB2332372B (en) 1997-12-08 2002-08-14 Minnesota Mining & Mfg Pharmaceutical aerosol compositions
GB9827370D0 (en) 1998-01-16 1999-02-03 Pari Gmbh Mouthpiece for inhalation therapy units
US7963955B2 (en) 1998-02-27 2011-06-21 Boehringer Ingelheim International Gmbh Container for a medicinal liquid
DE19808295A1 (de) 1998-02-27 1999-11-11 Boehringer Ingelheim Int Behälter für eine medizinische Flüssigkeit
US6685691B1 (en) 1998-02-27 2004-02-03 Boehringer Ingelheim Gmbh Container for a medicinal liquid
US5975370A (en) 1998-03-16 1999-11-02 Owens-Illinois Closure Inc. Tamper-evident plunger-hold-down attachment for pump dispenser
US6171972B1 (en) 1998-03-17 2001-01-09 Rosemount Aerospace Inc. Fracture-resistant micromachined devices
US6113078A (en) 1998-03-18 2000-09-05 Lytesyde, Llc Fluid processing method
GB9807558D0 (en) * 1998-04-09 1998-06-10 Bason Neil P An indicator device
US6378714B1 (en) 1998-04-20 2002-04-30 Becton Dickinson And Company Transferset for vials and other medical containers
US6729330B2 (en) * 1998-05-05 2004-05-04 Trudell Medical International Indicating device for aerosol container
US6257233B1 (en) 1998-06-04 2001-07-10 Inhale Therapeutic Systems Dry powder dispersing apparatus and methods for their use
US6267154B1 (en) 1998-06-05 2001-07-31 Abbott Laboratories System for storing mixing and administering a drug
DE19851279B4 (de) 1998-06-17 2006-05-24 GSF - Forschungszentrum für Umwelt und Gesundheit GmbH Vorrichtung zum gesteuerten inhalatorischen Einbringen von dosierten Medikamenten in die Lunge
KR100600423B1 (ko) 1998-06-18 2006-07-13 베링거 인겔하임 파마슈티칼즈, 인코포레이티드 2개 이상의 활성 물질을 포함하는 연무질 약제학적 제형
US6423298B2 (en) 1998-06-18 2002-07-23 Boehringer Ingelheim Pharmaceuticals, Inc. Pharmaceutical formulations for aerosols with two or more active substances
WO2000001612A2 (en) 1998-07-06 2000-01-13 Iep Group, Inc. Counter for fluid dispenser
US6584976B2 (en) 1998-07-24 2003-07-01 3M Innovative Properties Company Face mask that has a filtered exhalation valve
GB2333129A (en) 1998-09-15 1999-07-14 Thomas David White Spray dispenser with collapsible container
JP2957176B1 (ja) 1998-09-24 1999-10-04 株式会社三五 二重構造容器の製造方法
ID29605A (id) 1998-10-17 2001-09-06 Boehringer Ingelheim Pharma Konsentrat bahan aktif dengan formoterol, yang sesuai untuk penyimpanan
DE19847968A1 (de) 1998-10-17 2000-04-20 Boehringer Ingelheim Pharma Verschlußkappe und Behälter als Zweikammer-Kartusche für Vernebler zur Erzeugung von Aerosolen
US6745763B2 (en) 1998-10-27 2004-06-08 Garth T. Webb Vaporizing device for administering sterile medication
US6152296A (en) 1998-11-06 2000-11-28 Shih; Kuang-Sheng Additive holder for a pet bottle
DE19851404A1 (de) 1998-11-07 2000-05-11 Boehringer Ingelheim Int Druckausgleichsvorrichtung für einen Doppelbehälter
US6110247A (en) 1998-11-13 2000-08-29 Mesosystems Technology, Inc. Micromachined impactor pillars
NL1010749C2 (nl) 1998-12-07 2000-06-08 V O F Pharmasept Houder voor het gedoseerd en in hoofdzaak kiemvrij afgeven van een vloeistof.
US6186409B1 (en) 1998-12-10 2001-02-13 Bowles Fluidics Corporation Nozzles with integrated or built-in filters and method
US6352152B1 (en) 1998-12-18 2002-03-05 Smithkline Beecham Corporation Method and package for storing a pressurized container containing a drug
US6390291B1 (en) 1998-12-18 2002-05-21 Smithkline Beecham Corporation Method and package for storing a pressurized container containing a drug
US6315112B1 (en) 1998-12-18 2001-11-13 Smithkline Beecham Corporation Method and package for storing a pressurized container containing a drug
US6119853A (en) 1998-12-18 2000-09-19 Glaxo Wellcome Inc. Method and package for storing a pressurized container containing a drug
DE19902844C1 (de) 1999-01-20 1999-11-18 Kendall Med Erzeugnisse Gmbh Medikamentenvernebler mit verbessertem Prallschirm
GB9902493D0 (en) 1999-02-05 1999-03-24 Glaxo Group Ltd Inhalation device
AU3421600A (en) 1999-02-14 2000-08-29 Ing. Erich Pfeiffer Gmbh Dispenser for flowable media
GB2347870A (en) 1999-02-22 2000-09-20 Sunrise Medical Hhg Inc Medical nebuliser
DE19940713A1 (de) 1999-02-23 2001-03-01 Boehringer Ingelheim Int Kartusche für eine Flüssigkeit
GB9909357D0 (en) 1999-04-24 1999-06-16 Glaxo Group Ltd Medicament carrier
FR2793707B1 (fr) 1999-05-21 2002-02-15 Valois Sa Dispositif de distribution de produit fluide ameliore
SE9902672D0 (sv) * 1999-07-12 1999-07-12 Astra Ab Delivery device
DE19933330A1 (de) 1999-07-16 2001-01-18 Pfeiffer Erich Gmbh & Co Kg Spender für Medien
DE19937442A1 (de) 1999-08-07 2001-02-08 Pfeiffer Erich Gmbh & Co Kg Spender für strömungsfähige Medien, insbesondere zurZerstäubung von Flüssigkeiten
CA2382216A1 (en) 1999-08-20 2001-03-01 Xian Ming Zeng Method to produce powders for pulmonary or nasal administration
AU7340100A (en) 1999-08-31 2001-03-26 Kimberly-Clark Worldwide, Inc. Portable purification system
DE19942792A1 (de) 1999-09-08 2001-03-15 Pfeiffer Erich Gmbh & Co Kg Spender für Medien
AT409800B (de) 1999-09-13 2002-11-25 Hoffmann La Roche Verfahren und vorrichtung zur verbesserung der lagerfähigkeit tonometrierter flüssigkeiten
US6581596B1 (en) 1999-09-24 2003-06-24 Respironics, Inc. Apparatus and method of providing high frequency variable pressure to a patient
CA2390111C (en) 1999-10-06 2007-08-07 Raul Goldemann Breathing-controlled inhalation device for dry powder and method for the even distribution of said dry powder in the air
ES2214204T3 (es) 1999-10-14 2004-09-16 Becton, Dickinson And Company Dispositivo de administracion nasal que incluye una boquilla de pulverizacion.
GB2355252B (en) 1999-10-14 2002-01-23 Bespak Plc Improvements in drug delivery devices
US6136846A (en) 1999-10-25 2000-10-24 Supergen, Inc. Formulation for paclitaxel
IT1308581B1 (it) 1999-12-03 2002-01-08 Medel Italiana Srl Apparato per nebulizzare un liquido, in particolare per uso medico.
US6302101B1 (en) 1999-12-14 2001-10-16 Daniel Py System and method for application of medicament into the nasal passage
DE19962110C2 (de) 1999-12-22 2003-06-12 Pari Gmbh Inhalationsvernebler mit einstückigem Ventilelement
IT1317846B1 (it) 2000-02-22 2003-07-15 Chiesi Farma Spa Formulazioni contenenti un farmaco anticolinergico per il trattamentodella broncopneumopatia cronica ostruttiva.
ATE392885T1 (de) 2000-02-28 2008-05-15 Pharmakodex Ltd Verabreichungssystemen für oral anzuwendende arzneimittel
US6689092B2 (en) 2000-03-03 2004-02-10 Boehringer International Gmbh Needle-less injector of miniature type
US6701928B2 (en) 2000-04-06 2004-03-09 Wake Forest University Inhaler dispensing system adapters for laryngectomized subjects and associated methods
US6644305B2 (en) 2000-04-14 2003-11-11 Trudell Medical International Nasal inhaler
US6948494B1 (en) 2000-05-10 2005-09-27 Innovative Devices, Llc. Medicament container with same side airflow inlet and outlet and method of use
EP1284911B1 (en) 2000-05-19 2006-11-15 The Gillette Company System for dispensing multi-component products
SK286694B6 (sk) 2000-05-22 2009-03-05 Chiesi Farmaceutici S.P.A. Aerosólový farmaceutický prostriedok
US20020000225A1 (en) 2000-06-02 2002-01-03 Carlos Schuler Lockout mechanism for aerosol drug delivery devices
JP2001346878A (ja) 2000-06-12 2001-12-18 Terumo Corp 噴射式の薬液注入装置
AU2001270074A1 (en) 2000-06-22 2002-01-02 Glaxo Group Limited Method and package for storing a pressurized container containing a drug
US6325248B1 (en) 2000-07-05 2001-12-04 Robert E. Corba Container assembly
US6363932B1 (en) 2000-07-06 2002-04-02 Clinical Technologies, Inc. Aerosol enhancement device
MXPA02012859A (es) 2000-07-15 2003-05-14 Glaxo Group Ltd Dispensador de medicamento.
US6435175B1 (en) 2000-08-29 2002-08-20 Sensormedics Corporation Pulmonary drug delivery device
DE10049200A1 (de) 2000-10-05 2002-04-11 Clariant Gmbh Verfahren zur Herstellung von Azofarbmitteln
GB2367756B (en) 2000-10-12 2003-01-08 Bespak Plc Dispensing apparatus
US6706726B2 (en) 2000-10-14 2004-03-16 Boehringer Ingelheim Pharma Gmbh & Co. Kg Anticholinergics which may be used as medicaments as well as processes for preparing them
DE10050994A1 (de) 2000-10-14 2002-04-18 Boehringer Ingelheim Pharma Neue als Arneimittel einsetzbare Anticholinergika sowie Verfahren zu deren Herstellung
DE10050982A1 (de) 2000-10-16 2002-04-18 Pfeiffer Erich Gmbh & Co Kg Spender und Verfahren zum Austragen von Medien
DE20018518U1 (de) 2000-10-28 2001-02-01 Boehringer Ingelheim Pharma KG, 55218 Ingelheim Zerstäuber für Nasenspray
US6620438B2 (en) 2001-03-08 2003-09-16 Boehringer Ingelheim Pharma Kg Pharmaceutical compositions based on anticholinergics and NK1-receptor antagonists
US20020111363A1 (en) 2000-10-31 2002-08-15 Karin Drechsel Inhalable formulation of a solution containing a tiotropium salt
US20020137764A1 (en) 2000-10-31 2002-09-26 Karin Drechsel Inhalable formulation of a solution containing a tiotropium salt
FR2816523B1 (fr) 2000-11-15 2003-01-10 Oreal Tete de distribution nettoyable, et distributeur ainsi equipe
US6641782B1 (en) 2000-11-15 2003-11-04 Polaroid Corporation Apparatus for performing diagnostic testing
EP1211628B1 (en) 2000-11-30 2014-05-14 Canon Kabushiki Kaisha Inhaler and a discharge head control method
US6915901B2 (en) 2000-12-11 2005-07-12 Marc Feinberg Packaging assembly for surgical use
US6722364B2 (en) 2001-01-12 2004-04-20 Becton, Dickinson And Company Medicament inhalation delivery devices and methods for using the same
DE10104367A1 (de) 2001-02-01 2002-08-08 Boehringer Ingelheim Pharma Betamimetika enthaltende Arzneimittelkompositionen mit geringeren Nebenwirkungen
FR2821573B1 (fr) 2001-03-05 2003-06-13 Verbena Corp N V Buse de pulverisation a canaux profiles
GB0106046D0 (en) 2001-03-12 2001-05-02 Glaxo Group Ltd Canister
DE10111843A1 (de) 2001-03-13 2002-09-19 Boehringer Ingelheim Pharma Verbindungen zur Behandlung von inflammatorischen Erkrankungen
AU2002336246B8 (en) 2001-03-15 2006-02-02 Creare Incorporated Nebulizer having cooling chamber
US6550472B2 (en) 2001-03-16 2003-04-22 Aerogen, Inc. Devices and methods for nebulizing fluids using flow directors
WO2002076854A1 (en) 2001-03-26 2002-10-03 3M Innovative Properties Company Metering valve for a metered dose inhaler having improved flow
ATE367527T1 (de) 2001-04-27 2007-08-15 Hydrocision Inc Hochdruckeinwegpumpenkassette zur anwendung auf medizinischem gebiet
US6725858B2 (en) 2001-05-07 2004-04-27 Hudson Respiratory Care Inc. Valved aerosol tee adapter assembly
GB0114175D0 (en) 2001-06-11 2001-08-01 Glaxo Group Ltd Medicament dispenser
DE10131178A1 (de) 2001-06-29 2003-01-16 Boehringer Ingelheim Pharma Vernebler zur Applikation von Flüssigkeiten in die Augen
EP1417539A1 (en) 2001-08-10 2004-05-12 Paul Mayo Holt Methods and apparatus for use in photopolymer plate manufacture
GB2372575B (en) 2001-08-10 2003-01-15 Chemence Ltd Method for forming a sachet
TWI324934B (en) 2001-08-28 2010-05-21 Schering Corp Pharmaceutical compositions for the treatment of asthma
PT1446172E (pt) 2001-09-06 2010-05-06 Microdose Therapeutx Inc Inalador do tipo dpi
DE60209511T2 (de) 2001-09-18 2006-10-05 Nycomed Danmark Aps Zusammensetzungen zur behandlung des schnupfens, welche ipratropium und xylometazolin enthalten
WO2003035030A1 (en) 2001-10-24 2003-05-01 Pari Gmbh Kit for the preparation of a pharmaceutical composition
AU3297402A (en) 2001-10-26 2003-10-30 Dey, L.P. An albuterol and ipratropium inhalation solution, system, kit and method for relieving symptoms of chronic obstructive pulmonary disease
US20030191151A1 (en) 2001-10-26 2003-10-09 Imtiaz Chaudry Albuterol and ipratropium inhalation solution, system, kit and method for relieving symptoms of chronic obstructive pulmonary disease
US6779520B2 (en) 2001-10-30 2004-08-24 Iep Pharmaceutical Devices Inc. Breath actuated dry powder inhaler
EP1450802A2 (en) 2001-10-30 2004-09-01 The General Hospital Corporation Methods for the prevention or treatment of bacterial and fungal infections
TW565485B (en) 2001-11-07 2003-12-11 Sansha Electric Mfg Co Ltd Power supply apparatus for welder
DE10154237A1 (de) 2001-11-07 2003-05-15 Steag Microparts Gmbh Zerstäuber für manuelle Betätigung
WO2003045482A1 (en) 2001-11-26 2003-06-05 Bodrapan I/S Inhalation device
US20040092428A1 (en) 2001-11-27 2004-05-13 Hongming Chen Oral pharmaceuticals formulation comprising paclitaxel, derivatives and methods of administration thereof
DE10159692A1 (de) * 2001-11-29 2003-06-12 Pfeiffer Erich Gmbh & Co Kg Dosiervorrichtung
EP1461101A4 (en) 2001-12-07 2005-02-09 Glaxo Group Ltd DOSAGE VALVE, PHARMACEUTICAL AGENT AEROSOL-DOSER, AND METHODS THEREOF
NL1019562C2 (nl) 2001-12-13 2003-06-17 Heineken Tech Services Klepsamenstel voor gebruik bij drankafgifte.
BR0215184A (pt) 2001-12-20 2006-06-06 Bristol Myers Squibb Co composições farmacêuticas de derivados de taxano oralmente ativos tendo biodisponibilidade aumentada
US6994083B2 (en) 2001-12-21 2006-02-07 Trudell Medical International Nebulizer apparatus and method
EP1321159A1 (en) 2001-12-21 2003-06-25 CHIESI FARMACEUTICI S.p.A. Pressurized metered dose inhaler (pMDI) actuators with laser drilled orifices
US8777011B2 (en) 2001-12-21 2014-07-15 Novartis Ag Capsule package with moisture barrier
ATE406225T1 (de) 2002-01-17 2008-09-15 Quide B V Verfahren und formvorrichtung zum herstellen eines produkts mit unterschiedlichen durchmessern
SE0200312D0 (sv) 2002-02-01 2002-02-01 Astrazeneca Ab Novel composition
US6907879B2 (en) 2002-02-04 2005-06-21 Ndt Agent delivery and aspiration device
ATE311917T1 (de) 2002-02-14 2005-12-15 Atmed Ag Inhalationshilfsgerät
GB0204328D0 (en) 2002-02-25 2002-04-10 Fyne Dynamics Ltd Flow indicator
GB0204829D0 (en) 2002-03-01 2002-04-17 Glaxo Group Ltd A fluid dispensing device
US7004164B2 (en) * 2002-03-21 2006-02-28 Trudell Medical International Indicating device for aerosol container
JP4201520B2 (ja) 2002-04-09 2008-12-24 株式会社カナエ 滅菌袋の利用方法
US20040019073A1 (en) 2002-04-11 2004-01-29 Boehringer Ingelheim Pharma Gmbh Co. Kg Aerosol formulation for inhalation containing a tiotropium salt
PT1497289E (pt) 2002-04-12 2005-11-30 Boehringer Ingelheim Pharma Farmaco contendo betamimeticos e um novo anticolinergico
US7417051B2 (en) 2002-04-12 2008-08-26 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments comprising betamimetics and a novel anticholinergic
US6889690B2 (en) 2002-05-10 2005-05-10 Oriel Therapeutics, Inc. Dry powder inhalers, related blister devices, and associated methods of dispensing dry powder substances and fabricating blister packages
DE60330776D1 (de) 2002-05-10 2010-02-11 Oriel Therapeutics Inc Trockenpulverinhalator mit einer durch piezoelektrisches polymer angetriebenen abgabevorrichtung, und zugehörige blisterverpackung mit einem piezoelektrischen polymermaterial
CA2484578A1 (en) 2002-05-16 2003-11-27 Boehringer Ingelheim International Gmbh System comprising a nozzle and a fixing means therefor
EP1369139A1 (en) * 2002-06-03 2003-12-10 3M Innovative Properties Company Dose indicators and dispensing canister-indicator assemblies
US6832704B2 (en) 2002-06-17 2004-12-21 Summit Packaging Systems, Inc. Metering valve for aerosol container
DE10233150B4 (de) 2002-07-22 2013-03-07 Alfred Von Schuckmann Handbetätigbarer Inhalator für pulverförmige Substanzen
JP4261834B2 (ja) 2002-07-25 2009-04-30 泉工医科工業株式会社 液体バッグ、液体バッグ用口部材およびその製造方法
GB0217196D0 (en) 2002-07-25 2002-09-04 Glaxo Group Ltd Medicament dispenser
PT1658872E (pt) * 2002-07-31 2011-05-12 Chiesi Farma Spa Inalador de p?
CN1674887A (zh) 2002-08-14 2005-09-28 贝林格尔英格海姆法玛两合公司 含抗胆碱能剂的吸入用的气雾剂制剂
US20040166065A1 (en) 2002-08-14 2004-08-26 Boehringer Ingelheim Pharma Gmbh & Co. Kg Aerosol formulation for inhalation comprising an anticholinergic
US7337776B2 (en) 2002-08-20 2008-03-04 Aga Ab Methods for easing pain and anxiety from atrial or ventricular defibrillation
NZ538925A (en) 2002-08-28 2007-03-30 Boehringer Ingelheim Int Blocking device for a sprung lock with a spring operation
US7396341B2 (en) 2002-08-28 2008-07-08 Boehringer Ingelheim International Gmbh Blocking device for a locking stressing mechanism having a spring-actuated output drive device
AU2003260754B2 (en) 2002-08-29 2009-12-03 Cipla Limited Pharmaceutical products and compositions comprising specific anticholinergic agents, beta-2 agonists and corticosteroids
US20040045546A1 (en) 2002-09-05 2004-03-11 Peirce Management, Llc Pharmaceutical delivery system for oral inhalation through nebulization consisting of inert substrate impregnated with substance (S) to be solubilized or suspended prior to use
PL375495A1 (en) 2002-09-05 2005-11-28 Boehringer Ingelheim Pharma Gmbh & Co.Kg Device for discharging liquids, a cartridge suited therefor, and system comprised of the device for discharging liquids and of the cartridge
JP4261851B2 (ja) 2002-09-11 2009-04-30 キヤノン株式会社 吸入装置および該吸入装置の制御方法
US20040102470A1 (en) 2002-09-13 2004-05-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Method for improving the ability of patients suffering from lung diseases to participate in and benefit from pulmonary rehabilitation programs
US6896129B2 (en) 2002-09-20 2005-05-24 Illinois Tool Works Inc. Banded container package with opening feature
US7322352B2 (en) * 2002-09-21 2008-01-29 Aventis Pharma Limited Inhaler
US6776834B2 (en) 2002-09-23 2004-08-17 Ict Coatings N.V. Composition for treating substrate and process of treatment
EP1556646B1 (en) 2002-10-07 2013-12-18 Becton, Dickinson and Company Method for filling a container having at least one flexible component
US6772911B2 (en) 2002-10-15 2004-08-10 Kevin Gee Flow controller for container
FR2846308B1 (fr) * 2002-10-28 2006-02-10 Valois Sas Dispositif de distribution de produit fluide avec indicateur de dose
GB0226021D0 (en) * 2002-11-07 2002-12-18 Corporate Intellectual Propert A container
US7621266B2 (en) 2003-01-14 2009-11-24 Boehringer Ingelheim International Gmbh Nozzle-system for a dispenser for fluids consisting of a nozzle and a nozzle-holder and/or screw cap
DE10300983A1 (de) 2003-01-14 2004-07-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg Düsensystem für eine Ausbringungsvorrichtung für Flüssigkeiten bestehend aus Düse und Düsenhalter und/oder Überwurfmutter
GB0300939D0 (en) 2003-01-16 2003-02-12 Unilever Plc Method of creating a cosmetic spray
JP2004244109A (ja) 2003-01-24 2004-09-02 Toyo Aerosol Ind Co Ltd 二液分配用エアゾ−ル装置。
GB2398253B (en) 2003-02-11 2005-08-31 Bespak Plc Dispensing apparatus
US7331340B2 (en) * 2003-03-04 2008-02-19 Ivax Corporation Medicament dispensing device with a display indicative of the state of an internal medicament reservoir
MXPA05009920A (es) 2003-03-20 2005-11-04 Boehringer Ingelheim Pharma Formulacion para un inhalador con dosis medida que emplea hidrofluoroalcanos como propulsores.
US6837089B2 (en) 2003-04-03 2005-01-04 Ball Corporation Method and apparatus for reforming and reprofiling a bottom portion of a container
FR2853635B1 (fr) 2003-04-09 2007-04-06 Rexam Dispensing Sys Bouton-poussoir de pulverisateur
US7360537B2 (en) 2003-04-16 2008-04-22 Trudell Medical International Antistatic medication delivery apparatus
JP4154317B2 (ja) 2003-04-25 2008-09-24 トヨタ自動車株式会社 燃料噴射弁
DE10320143A1 (de) 2003-05-06 2004-12-16 Pari GmbH Spezialisten für effektive Inhalation Vernebleranschlussvorrichtung für Beatmungsgeräte oder dergleichen
DE20307306U1 (de) 2003-05-09 2003-07-24 K-Jump Health Co., Ltd., Wu-Ku, Taipeh/T'ai-pei Medizinischer, mechanischer Kompressorzerstäubungsapparat
FR2854973B1 (fr) * 2003-05-15 2005-08-19 Valois Sas Compteur de doses pour distributeur de produit fluide.
DE10323603A1 (de) 2003-05-20 2004-12-30 Ing. Erich Pfeiffer Gmbh Dosiervorrichtung mit einer Pumpeinrichtung
JP2006528228A (ja) 2003-05-22 2006-12-14 アルタナ　ファルマ　アクチエンゲゼルシャフト サルメテロール及びシクレソニドの組合せ物
US7896264B2 (en) 2003-06-30 2011-03-01 Boehringer Ingelheim International Gmbh Microstructured high pressure nozzle with built-in filter function
BRPI0412043B1 (pt) 2003-06-30 2018-01-23 Boehringer Ingelheim International Gmbh Bocal microestruturado com filtro, vaporizador para terapia de inalação e processo para a fabricação do referido bocal
US7273603B2 (en) 2003-07-11 2007-09-25 Boehringer Ingelheim International Gmbh HFC solution formulations containing an anticholinergic
US7600512B2 (en) 2003-07-14 2009-10-13 Vortran Medical Technology 1, Inc. Inhaler with breath actuated dose counter
DE202004021188U1 (de) * 2003-07-14 2007-03-15 Neo-Inhalation Ltd., Odiham Inhalationsgerät
CN100435970C (zh) 2003-07-16 2008-11-26 泊灵格英格尔海姆药品两合公司 一种用板状复合结构来生产微流体装置的工艺方法
ATE345173T1 (de) 2003-07-16 2006-12-15 Boehringer Ingelheim Micropart Verfahren zur herstellung von mikrofluidanordnungen aus einer plattenförmigen verbundstruktur
US20050028815A1 (en) 2003-07-23 2005-02-10 Deaton Daniel M. Apparatus for electronic dosage counter
DE10339197A1 (de) 2003-08-22 2005-03-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg Sprühgetrocknete amorphe Pulver mit geringer Restfeuchte und guter Lagerstabilität
DE10345065A1 (de) 2003-09-26 2005-04-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Aerosolformulierung für die Inhalation enthaltend ein Anticholinergikum
US7621273B2 (en) * 2003-10-28 2009-11-24 Trudell Medical International Indicating device with warning dosage indicator
JP3792690B2 (ja) 2003-11-11 2006-07-05 松本重工業株式会社 熱交換器用の異形伝熱管の製造方法
GB0328564D0 (en) 2003-12-10 2004-01-14 Dunne Stephen T Variable flow discharge metered dose valve
DE10358387A1 (de) 2003-12-13 2005-07-07 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pulver enthaltend niedermolekulares Dextran und Verfahren zu deren Herstellung
US20050191246A1 (en) 2003-12-13 2005-09-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Powders comprising low molecular dextran and methods of producing those powders
US7100530B2 (en) 2003-12-15 2006-09-05 Trudell Medical International, Inc. Dose indicating device
US8210166B2 (en) 2003-12-16 2012-07-03 Wolfe Tory Medical, Inc. Vial multi-access adapter
DE102004001451A1 (de) 2004-01-08 2005-08-11 Boehringer Ingelheim International Gmbh Vorrichtung zum Haltern eines fluidischen Bauteiles
JP2007517529A (ja) 2004-01-09 2007-07-05 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ノズル、ノズル・ホルダ、及び／又はチェック・ナットを備えた液体用供給装置のためのノズル・システム
GB0402694D0 (en) 2004-02-06 2004-03-10 Glaxo Group Ltd A fluid dispenser
EP1727579A1 (en) 2004-02-12 2006-12-06 Geir Jansen Medicament dispenser
DE102004009435A1 (de) 2004-02-24 2005-12-08 Boehringer Ingelheim International Gmbh Zerstäuber
DE102004009434A1 (de) 2004-02-24 2005-12-15 Boehringer Ingelheim International Gmbh Zerstäuber
US20050183718A1 (en) 2004-02-24 2005-08-25 Boehringer Ingelheim International Gmbh Nebulizer
ES2765048T3 (es) 2004-03-10 2020-06-05 Glaxo Group Ltd Un dispositivo de dispensación con elemento de restricción
US7258716B2 (en) 2004-03-22 2007-08-21 Joseph Gerard Birmingham Microimpactor system having optimized impactor spacing
JP4397729B2 (ja) * 2004-03-26 2010-01-13 株式会社資生堂 カウンター機構付きエアゾール
EP1737517B1 (en) * 2004-04-02 2010-10-06 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services Aerosol delivery systems
US20050239778A1 (en) 2004-04-22 2005-10-27 Boehringer Ingelheim International Gmbh Novel medicament combinations for the treatment of respiratory diseases
CA2564041A1 (en) 2004-04-24 2005-11-17 Christopher E. Bossi Universal medication carrier
DE102004021789A1 (de) 2004-05-03 2006-04-27 Boehringer Ingelheim International Gmbh Zerstäuber zum Ausbringen von Flüssigkeiten für medizinische Zwecke
DE102004022928A1 (de) 2004-05-10 2005-12-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pulver enthaltend neuartige Oligosacharidgemische und Verfahren zu deren Herstellung
US7727962B2 (en) 2004-05-10 2010-06-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Powder comprising new compositions of oligosaccharides and methods for their preparation
US7611709B2 (en) 2004-05-10 2009-11-03 Boehringer Ingelheim Pharma Gmbh And Co. Kg 1,4 O-linked saccharose derivatives for stabilization of antibodies or antibody derivatives
US7191776B2 (en) 2004-05-10 2007-03-20 Smiths Medical Asd, Inc. Nebulizer breathing system
US7723306B2 (en) 2004-05-10 2010-05-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Spray-dried powder comprising at least one 1,4 O-linked saccharose-derivative and methods for their preparation
DE102004022927A1 (de) 2004-05-10 2005-12-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg 1,4 O-verknüpfte Saccharose-Derivate zur Stabilisierung von Antikörpern oder Antikörper-Derivaten
DE102004022926A1 (de) 2004-05-10 2005-12-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Sprühgetrocknete Pulver enthaltend zumindest ein 1,4 O-verknüpftes Saccharose-Derivat und Verfahren zu deren Herstellung
US7448385B2 (en) 2004-06-07 2008-11-11 Purepharm Inc. Nasal adaptation of an oral inhaler device
DE102004031673B4 (de) 2004-06-30 2009-04-16 Erbe Elektromedizin Gmbh Medizinische Pumpe
SE0401773D0 (sv) 2004-07-02 2004-07-02 Astrazeneca Ab An inhalation and a method for assemnling said inhalation device
JP5209963B2 (ja) 2004-07-02 2013-06-12 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 噴霧剤としてｔｇ２２７ｅａ又はｔｇ１３４ａを含有するエアロゾル懸濁製剤
SE0401786D0 (sv) * 2004-07-05 2004-07-05 Astrazeneca Ab Inhaler device
EP1616629B1 (de) 2004-07-13 2014-04-02 Aptar Radolfzell GmbH Betätigungseinrichtung für einen Medienspender
KR101214823B1 (ko) * 2004-07-16 2012-12-24 알미랄, 에스.에이. 분말 약제의 투약을 위한 흡입기 및 이 흡입기와 함께사용하기 위한 분말 카트리지 시스템
KR101038403B1 (ko) 2004-07-28 2011-06-01 다이닛본 스미토모 세이야꾸 가부시끼가이샤 복수의 층을 갖는 필름-코팅된 정제
DE102004038885A1 (de) 2004-08-10 2006-02-23 Boehringer Ingelheim Pharma Gmbh & Co. Kg Aerosolformulierung für die Inhalation enthaltend ein Anticholinergikum
GB2417024B (en) 2004-08-11 2007-01-03 Bespak Plc Improvements in metering valves for dispensers
WO2006027595A1 (en) 2004-09-09 2006-03-16 Cipla Limited Pharmaceutical composition comprising an isomer of a betamimetic agent and an anti-cholinergic agent
US8557861B2 (en) 2004-09-28 2013-10-15 Mast Therapeutics, Inc. Low oil emulsion compositions for delivering taxoids and other insoluble drugs
WO2006037636A2 (en) 2004-10-06 2006-04-13 Boehringer Ingelheim International Gmbh Dispensing device, storage device and method for dispensing powder
GB0422413D0 (en) 2004-10-08 2004-11-10 Breath Ltd High efficiency nebulisation
EP1807136A2 (en) 2004-10-12 2007-07-18 Aradigm Corporation Device and method for generating an aerosol from a liquid formulation and ensuring its sterility
DE102004052360A1 (de) 2004-10-28 2006-05-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung eines mit einer Behälteröffung versehenen Behälters und nach diesem Verfahren hergestellte Behälter
DE102005033398A1 (de) * 2004-11-10 2006-05-11 Alfred Von Schuckmann Inhalier-Gerät
MXPA05001982A (es) 2004-12-22 2006-06-21 Ursapharm Arzneimittel Gmbh Despachador de fluidos.
CA2592413C (en) 2005-01-20 2015-11-17 Trudell Medical International Dispensing device having a connector between the housing and container
GB2422786B (en) 2005-03-03 2007-05-23 Bespak Plc Dispenser
FR2883400B1 (fr) 2005-03-16 2007-06-15 Valois Sas Dispositif d'indication de doses pour distribuer des produits fluides ou pulverulents
US20060225734A1 (en) 2005-04-08 2006-10-12 Ox-Gen Inc. Filter for oxygen delivery systems
GB0507224D0 (en) 2005-04-09 2005-05-18 Glaxo Group Ltd A fluid dispensing device
TWI442951B (zh) 2005-04-14 2014-07-01 Astrazeneca Ab 吸入器計量器
AU2006239821B2 (en) 2005-04-22 2011-11-10 Becton, Dickinson And Company Prepackaged medical device, packaging tray, and method
GB2425603B (en) 2005-04-27 2009-03-18 Hewlett Packard Development Co Apparatus that uses consumable items and a method of managing such apparatus
DE102005024439A1 (de) 2005-05-24 2006-12-07 Boehringer Ingelheim International Gmbh Zerstäuber
US20090173751A1 (en) 2005-05-26 2009-07-09 Incro Limited Check valve and a split-body fluid device having such a check valve
DE102005029498B4 (de) 2005-06-24 2007-08-30 Pari GmbH Spezialisten für effektive Inhalation Inhalationstherapievorrichtung
DE102005029746B4 (de) 2005-06-24 2017-10-26 Boehringer Ingelheim International Gmbh Zerstäuber
WO2007011475A1 (en) 2005-07-15 2007-01-25 Albemarle Corporation Middle phase micro emulsions and process of making and using the same
DE102005035705A1 (de) 2005-07-27 2007-02-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Arzneimittelblister
AU2006284173A1 (en) 2005-08-24 2007-03-01 Boehringer Ingelheim International Gmbh Atomiser comprising a counter and an end of operation lock
US7980045B2 (en) 2006-06-14 2011-07-19 International Packaging Solutions Llc Systems and methods for filling a collapsible container
GB0518770D0 (en) 2005-09-14 2005-10-26 Glaxo Group Ltd A closure for a dispensing device
GB0519151D0 (en) * 2005-09-20 2005-10-26 Aventis Pharma Ltd Inhaler
CA2623256A1 (en) 2005-09-29 2007-04-12 Nektar Therapeutics Receptacles and kits, such as for dry powder packaging
US20070090576A1 (en) 2005-10-20 2007-04-26 Boehringer Ingelheim International Gmbh Process for forming a container opening
GB0521510D0 (en) * 2005-10-21 2005-11-30 Novartis Ag Organic compounds
EP1779933A1 (en) 2005-10-26 2007-05-02 The Procter and Gamble Company Dispenser for a liquid
DE102005055960A1 (de) 2005-11-24 2007-07-19 Boehringer Ingelheim Pharma Gmbh & Co. Kg Aerosolformulierung für die Inhalation enthaltend ein Anticholinergikum
DE102005055963A1 (de) 2005-11-24 2007-07-19 Boehringer Ingelheim Pharma Gmbh & Co. Kg Aerosolformulierung für die Inhalation enthaltend ein Anticholinergikum
DE102005055957A1 (de) 2005-11-24 2007-07-12 Boehringer Ingelheim Pharma Gmbh & Co. Kg Aerosolformulierung für die Inhalation enthaltend ein Anticholinergikum
DE102005055958A1 (de) 2005-11-24 2007-07-19 Boehringer Ingelheim Pharma Gmbh & Co. Kg Aerosolformulierung für die Inhalation enthaltend ein Anticholinergikum
DE102005055961A1 (de) 2005-11-24 2007-05-31 Boehringer Ingelheim Pharma Gmbh & Co. Kg Aerosolformulierung für die Inhalation enthaltend ein Anticholinergikum
EP1795221A1 (en) 2005-12-02 2007-06-13 Boehringer Ingelheim Pharma GmbH & Co. KG Dispensing device, storage device and method for dispensing a formulation
US7380575B2 (en) 2005-12-20 2008-06-03 Scholle Corporation Filler device for filling flexible bags
JP4877504B2 (ja) 2006-01-27 2012-02-15 マックス株式会社 ガスカートリッジ
DE102006053374A1 (de) 2006-02-09 2007-08-16 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmazeutische Formulierung für Aerosole mit zwei oder mehr Wirkstoffen und mindestens einer oberflächenaktiven Substanz
JP2007238074A (ja) 2006-02-10 2007-09-20 Aisin Seiki Co Ltd 車両用ルーフ自動開閉装置
CA2642638A1 (en) 2006-02-14 2007-08-23 Battelle Memorial Institute Accurate metering system
EP1991295B1 (en) * 2006-03-03 2016-02-10 3M Innovative Properties Company Apparatus for metered dosed dispensing
MX2008011252A (es) 2006-03-07 2008-09-10 Boehringer Ingelheim Int Tobera de remolino.
DE102006029753A1 (de) 2006-03-10 2007-09-13 Alfred Von Schuckmann Inhalator für pulverförmige Substanzen
EP1834705B1 (de) 2006-03-13 2011-09-14 Ing. Erich Pfeiffer GmbH Austragvorrichtung für ein fliessfähiges Medium
US20090308772A1 (en) 2006-03-17 2009-12-17 Abrams William S Moisture-tight primary packaging for a dry powder inhaler
WO2007107431A1 (en) 2006-03-21 2007-09-27 Shl Medical Ab Dose information device
US20070221211A1 (en) 2006-03-27 2007-09-27 Boris Sagalovich Apparatus and process for inhaling medicines
WO2007124406A2 (en) * 2006-04-21 2007-11-01 3M Innovative Properties Company Dose counter
DE102006022002A1 (de) 2006-05-10 2007-11-15 Boehringer Ingelheim International Gmbh Zerstäuber und Verfahren zur Zerstäubung von Fluid
WO2007134967A1 (de) 2006-05-19 2007-11-29 Boehringer Ingelheim International Gmbh Treibgasfreie aerosolformulierung für die inhalation enthaltend ipratropiumbromid und salbutamolsulfat
WO2007134965A1 (de) 2006-05-19 2007-11-29 Boehringer Ingelheim International Gmbh Aerosolformulierung enthaltend ipratropiumbromid und salbutamolsulfat
DE102006023756A1 (de) 2006-05-20 2007-11-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg Ethanolhaltige Aerosolformulierung für die Inhalation
DE102006023770A1 (de) 2006-05-20 2007-11-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg Treibgasfreie Aerosolformulierung für die Inhalation
GB0610541D0 (en) 2006-05-26 2006-07-05 Bespak Plc Improvements in or relating to dispensing apparatus
DE102006025884A1 (de) 2006-06-02 2007-12-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Adapter mit einem Anschluss für einen Zerstäuber
DE102006025871A1 (de) 2006-06-02 2007-12-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Zerstäuber
GB0614621D0 (en) 2006-07-24 2006-08-30 3M Innovative Properties Co Metered dose dispensers
US8141550B2 (en) 2006-08-01 2012-03-27 Trudell Medical International Dispensing device
EP2056908B1 (en) 2006-08-22 2020-02-26 Glaxo Group Limited Drug dispenser
FR2907435B1 (fr) 2006-10-20 2009-01-09 Valois Sas Dispositif de distribution de produit fluide.
DE202006017793U1 (de) 2006-11-22 2007-01-11 Tsai, Chang-Keng Pneumatischer Flüssigkeitsspender mit doppelwandigem Behälter
MX2009006787A (es) 2006-12-22 2009-07-10 Almirall Lab Dispositivo de inhalacion para medicamentos en forma de polvo.
GB2448112B (en) * 2007-01-16 2011-08-17 Bespak Plc Improvements in or relating to dispensing apparatus
GB0700839D0 (en) 2007-01-17 2007-02-21 Braithwaite Philip Device
US8413651B2 (en) 2007-04-06 2013-04-09 Becton, Dickinson And Company Disposable spacer for inhalation delivery of aerosolized drugs and vaccines
US8651335B2 (en) 2007-04-23 2014-02-18 Meadwestvaco Calmar, Inc. Tamper evident nozzle shield and methods for using the same
DE102007023012A1 (de) 2007-05-15 2008-11-20 Boehringer Ingelheim Pharma Gmbh & Co. Kg Zerstäuber und Filter
GB0710488D0 (en) 2007-06-01 2007-07-11 Innovatek Medical Ltd Methods of treating components of a medical dispenser device
WO2009006137A1 (en) 2007-07-03 2009-01-08 Glaxo Group Limited Aerosol canister employing a polymeric film having improved moisture barrier properties
DE102007045438B4 (de) 2007-09-22 2016-09-01 Boehringer Ingelheim International Gmbh Inhalier-Gerät
EP2044967A1 (de) 2007-10-01 2009-04-08 Boehringer Ingelheim Pharma GmbH & Co. KG Zerstäuber
ITMI20071936A1 (it) 2007-10-08 2008-01-07 Lumson Spa Metodo per la realizzazione di un dispositivo per contenere a tenuta d'aria e per erogare sostanze fluide e dispositivo cosi' ottenuto
FR2924353B1 (fr) * 2007-12-03 2010-12-17 Valois Sas Dispositif de distribution de produit fluide.
EP2077132A1 (en) 2008-01-02 2009-07-08 Boehringer Ingelheim Pharma GmbH & Co. KG Dispensing device, storage device and method for dispensing a formulation
WO2009090245A1 (en) 2008-01-16 2009-07-23 Bang & Olufsen Medicom A/S A dispenser
WO2009093969A1 (en) 2008-01-23 2009-07-30 Astrazeneca Ab A medicament-containing dispenser provided with a display for presenting indicia to a user
US9364841B2 (en) 2008-02-19 2016-06-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Cartridge system
AU2009226643A1 (en) 2008-03-17 2009-09-24 Boehringer Ingelheim International Gmbh Reservoir and nebulizer
US8096420B2 (en) 2008-04-30 2012-01-17 Ethicon Endo-Surgery, Inc. Universal blister package
EP2135632A1 (de) 2008-06-20 2009-12-23 Boehringer Ingelheim International Gmbh Inhalator
TW201014623A (en) 2008-07-08 2010-04-16 Schering Corp Cover for metered dose inhaler aerosol cans
CN102159265B (zh) 2008-07-15 2015-09-16 Shl集团有限责任公司 药物输送器件
DE102008044770A1 (de) 2008-08-28 2010-03-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Antriebseinheit für Dosiszähler
US8033518B2 (en) 2008-10-08 2011-10-11 Kurt Cameron Schuchman Beverage holder device
WO2010094305A1 (en) 2009-02-18 2010-08-26 Boehringer Ingelheim International Gmbh Device, cartridge and method for dispensing a liquid
PL2398595T3 (pl) 2009-02-18 2018-05-30 Boehringer Ingelheim International Gmbh Urządzenie, wkład i sposób dozowania cieczy
CA2752677A1 (en) 2009-02-18 2010-08-26 Boehringer Ingelheim International Gmbh Nebuliser
EP2236224B1 (de) 2009-03-30 2013-03-06 Boehringer Ingelheim International GmbH Umformwerkzeug mit einem rotierbaren Grundkörper zum Formen einer Inhalatorkartusche und Verwendung eines solchen Umformwerkzeugs
EP2236227B1 (de) 2009-03-30 2013-12-18 Boehringer Ingelheim International GmbH Umformwerkzeug mit einem rotierbaren Grundkörper
WO2010112358A2 (de) 2009-03-31 2010-10-07 Boehringer Ingelheim International Gmbh Verfahren zur beschichtung einer oberfläche eines bauteils
JP5763053B2 (ja) 2009-05-18 2015-08-12 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング アダプタ、吸入器具及びアトマイザ
AR076624A1 (es) 2009-06-02 2011-06-22 Sanofi Aventis Deutschland Suministro de dos o mas medicametos por medio de una unica seleccion de dosis y una unica interfaz de dispensacion
EP2275160A1 (de) 2009-07-13 2011-01-19 Boehringer Ingelheim International Gmbh Hochdruckkammer
DE102009049902A1 (de) * 2009-10-13 2011-04-14 Ing. Erich Pfeiffer Gmbh Austragvorrichtung
JP5658268B2 (ja) 2009-11-25 2015-01-21 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ネブライザ
EA026241B1 (ru) * 2009-11-25 2017-03-31 Бёрингер Ингельхайм Интернациональ Гмбх Распылитель
US10016568B2 (en) 2009-11-25 2018-07-10 Boehringer Ingelheim International Gmbh Nebulizer
NZ599279A (en) 2009-11-25 2014-09-26 Boehringer Ingelheim Int Nebulizer
US8834443B2 (en) 2010-03-22 2014-09-16 Alex Yeung Injection safety system
WO2011131779A1 (en) 2010-04-23 2011-10-27 Sanofi-Aventis Deutschland Gmbh Drug delivery device and drug reservoir with mechanical coding mechanism
WO2011154295A2 (de) 2010-06-08 2011-12-15 Boehringer Ingelheim International Gmbh Medizinisches gerät mit zählwerk mit voreingestelltem zählbereich gerät mit zählwerksvariation
JP5874724B2 (ja) 2010-06-24 2016-03-02 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ネブライザ
US9154890B2 (en) 2011-02-23 2015-10-06 Cochlear Limited Wireless data transmission with predictive transmission adjustment
WO2012130757A1 (de) 2011-04-01 2012-10-04 Boehringer Ingelheim International Gmbh Medizinisches gerät mit behälter
DK2526989T3 (da) 2011-05-23 2020-04-06 Boehringer Ingelheim Int System omfattende en forstøver
WO2012161685A1 (en) 2011-05-23 2012-11-29 Boehringer Ingelheim International Gmbh Nebulizer
US10080853B2 (en) * 2011-05-23 2018-09-25 Boehringer Ingelheim International Gmbh Nebulizer
US9827384B2 (en) 2011-05-23 2017-11-28 Boehringer Ingelheim International Gmbh Nebulizer
EP2614848B1 (de) 2012-01-13 2020-07-01 Boehringer Ingelheim International GmbH Inhalator und Kapsel für einen Inhalator
GB201115874D0 (en) * 2011-09-14 2011-10-26 Astrazeneca Ab Inhaler
EP2617448A1 (en) 2012-01-20 2013-07-24 Almirall S.A. Inhalation device for powdered drugs
US20150306322A9 (en) 2012-01-23 2015-10-29 Sanofi Sa Inhalation Device
US20140352692A1 (en) * 2012-01-23 2014-12-04 Sanofi Sa Dose Counting Mechanism for an Inhalation Device and Inhalation Device
WO2013152894A1 (de) 2012-04-13 2013-10-17 Boehringer Ingelheim International Gmbh Zerstäuber mit kodiermitteln
US20140053838A1 (en) * 2012-07-12 2014-02-27 Annaniy Berenshteyn Dose counter assembly for inhaler
US9872964B2 (en) * 2012-08-22 2018-01-23 Presspart Gmbh & Co. Kg Metered dose inhaler counter and metered-dose inhaler including such a counter
US8910639B2 (en) * 2012-09-05 2014-12-16 R. J. Reynolds Tobacco Company Single-use connector and cartridge for a smoking article and related method
JP2016525437A (ja) 2013-08-09 2016-08-25 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ネブライザ
EP2835146B1 (en) 2013-08-09 2020-09-30 Boehringer Ingelheim International GmbH Nebulizer
US9744313B2 (en) 2013-08-09 2017-08-29 Boehringer Ingelheim International Gmbh Nebulizer
DK3139979T3 (da) 2014-05-07 2023-10-09 Boehringer Ingelheim Int Enhed, forstøver og fremgangsmåde
NZ724449A (en) 2014-05-07 2022-01-28 Boehringer Ingelheim Int Nebulizer and container

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10716907B2 (en) 2014-05-07 2020-07-21 Boehringer Ingelheim International Gmbh Nebulizer
WO2024209239A1 (en) 2023-04-06 2024-10-10 Neutec Inhaler Ilac Sanayi Ve Ticaret Anonim Sirketi Nebulizer and container for a nebulizer

Also Published As

Publication number Publication date
HUE053905T2 (hu) 2021-07-28
IL248068A0 (en) 2016-11-30
IL248068B (en) 2021-02-28
NZ724463A (en) 2021-11-26
US10576222B2 (en) 2020-03-03
RS63171B1 (sr) 2022-05-31
BR112016023719B1 (pt) 2021-12-21
SI3139982T1 (sl) 2022-05-31
AR100963A1 (es) 2016-11-16
AU2015258110A1 (en) 2016-10-20
US10099022B2 (en) 2018-10-16
MX2016014402A (es) 2017-01-20
EA201692241A1 (ru) 2017-05-31
AU2019203628B2 (en) 2020-09-03
PH12016502192A1 (en) 2017-01-16
KR20170016835A (ko) 2017-02-14
HRP20220596T1 (hr) 2022-06-24
EA201990525A2 (ru) 2019-07-31
ES2957901T3 (es) 2024-01-29
NZ724449A (en) 2022-01-28
ES2913297T3 (es) 2022-06-01
EP4052747A1 (en) 2022-09-07
WO2015169431A8 (en) 2016-10-20
JP2017514621A (ja) 2017-06-08
UY36115A (es) 2015-11-30
HUE058904T2 (hu) 2022-09-28
CL2016002801A1 (es) 2017-03-31
US10716906B2 (en) 2020-07-21
BR122022010094B1 (pt) 2023-10-03
EP3139981B1 (en) 2020-12-23
IL247926B (en) 2020-08-31
PT3139979T (pt) 2023-09-28
AU2019204569B2 (en) 2020-11-05
PH12019501875A1 (en) 2020-02-03
EP4242916A2 (en) 2023-09-13
MX2022005015A (es) 2022-05-16
KR102443739B1 (ko) 2022-09-19
PH12019501875B1 (en) 2020-02-03
PH12016502192B1 (en) 2017-01-16
PL3139983T3 (pl) 2024-01-03
CA2945018C (en) 2023-08-01
DK3928818T3 (da) 2023-04-17
CA2945028A1 (en) 2015-11-12
PL3139982T3 (pl) 2022-06-06
JP6594340B2 (ja) 2019-10-23
US20170049977A1 (en) 2017-02-23
RS64124B1 (sr) 2023-05-31
JP2019141706A (ja) 2019-08-29
KR102382358B1 (ko) 2022-04-05
EA032599B1 (ru) 2019-06-28
CL2016002803A1 (es) 2017-02-03
EA033013B1 (ru) 2019-08-30
DK3139982T3 (da) 2022-05-16
AU2019203628A1 (en) 2019-06-13
EP3139981A2 (en) 2017-03-15
AR121077A2 (es) 2022-04-13
SG10201709354PA (en) 2018-01-30
AU2015258110B2 (en) 2019-06-20
UA121114C2 (uk) 2020-04-10
BR112016023930A2 (pt) 2017-08-15
EP3139982B1 (en) 2022-02-16
JP2017514628A (ja) 2017-06-08
EA201692236A1 (ru) 2017-05-31
EP3139983A2 (en) 2017-03-15
PL3139981T3 (pl) 2021-06-14
KR20170003603A (ko) 2017-01-09
CA2945028C (en) 2023-09-05
WO2015169759A1 (en) 2015-11-12
PE20210959A1 (es) 2021-05-25
AU2015258107B2 (en) 2019-12-19
BR112016023719A2 (pt) 2017-08-15
BR112016023720A2 (pt) 2017-08-15
EP4052747A8 (en) 2023-04-12
CN106456908B (zh) 2020-07-24
DK3139981T3 (da) 2021-02-15
NZ724724A (en) 2022-01-28
CN111821546B (zh) 2023-01-13
EA035261B1 (ru) 2020-05-21
IL248069A0 (en) 2016-11-30
EP3139980A1 (en) 2017-03-15
CN106232165B (zh) 2020-01-17
AU2015257815B2 (en) 2019-05-02
KR20230018542A (ko) 2023-02-07
US20150320947A1 (en) 2015-11-12
IL247928A0 (en) 2016-11-30
CN106456908A (zh) 2017-02-22
AU2019204569A1 (en) 2019-08-22
CL2016002800A1 (es) 2017-01-27
BR112016023932A2 (pt) 2017-08-15
BR112016023720B1 (pt) 2022-11-16
EP3139983B1 (en) 2023-07-19
PT3928818T (pt) 2023-03-21
MX2016014401A (es) 2017-01-20
FI3928818T3 (fi) 2023-05-03
MY187485A (en) 2021-09-24
HUE061969T2 (hu) 2024-02-28
JP6745225B2 (ja) 2020-08-26
BR112016023932B1 (pt) 2022-11-29
IL247928B (en) 2021-03-25
WO2015169428A3 (en) 2015-12-30
CN106232165A (zh) 2016-12-14
CA2948066A1 (en) 2015-11-12
AU2015258108B2 (en) 2019-10-10
AU2015257815A1 (en) 2016-10-06
WO2015169431A3 (en) 2015-12-30
HUE063833T2 (hu) 2024-02-28
CA2945018A1 (en) 2015-11-12
CN106456913A (zh) 2017-02-22
CN116036425A (zh) 2023-05-02
TW201615235A (zh) 2016-05-01
EA032459B1 (ru) 2019-05-31
NZ724723A (en) 2021-11-26
EA032832B1 (ru) 2019-07-31
CL2019001772A1 (es) 2019-10-18
PH12016502191A1 (en) 2017-02-06
US10716907B2 (en) 2020-07-21
AP2016009486A0 (en) 2016-10-31
WO2015169431A2 (en) 2015-11-12
LT3928818T (lt) 2023-03-27
ES2941661T3 (es) 2023-05-24
IL248069B (en) 2020-08-31
CA2948066C (en) 2023-10-03
EA201692240A1 (ru) 2017-05-31
PH12016502190B1 (en) 2017-01-16
PT3139982T (pt) 2022-04-05
WO2015169429A3 (en) 2016-01-21
CA2948072A1 (en) 2015-11-12
EA201692239A1 (ru) 2017-03-31
IL247926A0 (en) 2016-11-30
WO2015169429A2 (en) 2015-11-12
LT3139982T (lt) 2022-04-11
US20170072149A1 (en) 2017-03-16
PE20161564A1 (es) 2017-01-25
CN111821546A (zh) 2020-10-27
AU2015258108A1 (en) 2016-10-20
JP2017514619A (ja) 2017-06-08
ES2853775T3 (es) 2021-09-17
CA2948072C (en) 2023-06-27
DK3139983T3 (da) 2023-09-11
PH12016502193A1 (en) 2017-02-06
SI3928818T1 (sl) 2023-04-28
KR20170005036A (ko) 2017-01-11
MX2016014403A (es) 2017-01-20
JP6992023B2 (ja) 2022-01-13
AU2015258107A1 (en) 2016-10-06
KR102492824B1 (ko) 2023-01-30
JP2017515562A (ja) 2017-06-15
EP3928818B1 (en) 2023-02-01
CN106232166A (zh) 2016-12-14
KR102409529B1 (ko) 2022-06-17
KR20170016833A (ko) 2017-02-14
EP4242916A3 (en) 2023-11-08
EP3139982A2 (en) 2017-03-15
EP3928818A1 (en) 2021-12-29
PH12016502190A1 (en) 2017-01-16
EA201990525A3 (ru) 2019-11-29
PL3928818T3 (pl) 2023-06-26
HRP20230370T1 (hr) 2023-06-23
BR112016023930B1 (pt) 2021-12-28
JP6643252B2 (ja) 2020-02-12
CN106232166B (zh) 2020-04-14
MX2016014399A (es) 2017-01-20
JP6526057B2 (ja) 2019-06-05
TWI607770B (zh) 2017-12-11
US20170072148A1 (en) 2017-03-16
CN106456913B (zh) 2019-08-30
CL2016002799A1 (es) 2017-02-10
SG11201608891RA (en) 2016-11-29

Similar Documents

Publication Publication Date Title
AU2019203628B2 (en) Nebulizer, indicator device and container
US10722666B2 (en) Nebulizer with axially movable and lockable container and indicator
EP3374011B1 (en) System comprising nebulizer and container
NZ724463B2 (en) Nebulizer
NZ724723B2 (en) Nebulizer, indicator device and container

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 15724938

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 247926

Country of ref document: IL

ENP Entry into the national phase

Ref document number: 2015258107

Country of ref document: AU

Date of ref document: 20150504

Kind code of ref document: A

REG Reference to national code

Ref country code: BR

Ref legal event code: B01A

Ref document number: 112016023720

Country of ref document: BR

ENP Entry into the national phase

Ref document number: 2016566222

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: MX/A/2016/014399

Country of ref document: MX

ENP Entry into the national phase

Ref document number: 2948066

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 15308879

Country of ref document: US

Ref document number: 12016502190

Country of ref document: PH

NENP Non-entry into the national phase

Ref country code: DE

REEP Request for entry into the european phase

Ref document number: 2015724938

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2015724938

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 20167033120

Country of ref document: KR

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 201692239

Country of ref document: EA

ENP Entry into the national phase

Ref document number: 112016023720

Country of ref document: BR

Kind code of ref document: A2

Effective date: 20161011