KR960704591A - 의학 물질의 용액, 현탁액 또는 에멀션의 제제를 위한 장치(device for the preparation fo a solution. a suspension or an emulsion of a medicinal substance) - Google Patents

의학 물질의 용액, 현탁액 또는 에멀션의 제제를 위한 장치(device for the preparation fo a solution. a suspension or an emulsion of a medicinal substance)

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KR960704591A
KR960704591A KR1019960700447A KR19960700447A KR960704591A KR 960704591 A KR960704591 A KR 960704591A KR 1019960700447 A KR1019960700447 A KR 1019960700447A KR 19960700447 A KR19960700447 A KR 19960700447A KR 960704591 A KR960704591 A KR 960704591A
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container
piston
dish
stopper
sleeve
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메이어 가브리엘
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메이어 가브리엘
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2093—Containers having several compartments for products to be mixed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2422—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule
    • A61M5/2429—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule by telescoping of ampoules or carpules with the syringe body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2448—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/50—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/2013—Piercing means having two piercing ends
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202—Separating means
    • A61J1/2031—Separating means having openings brought into alignment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202—Separating means
    • A61J1/2044—Separating means having slits
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2051—Connecting means having tap means, e.g. tap means activated by sliding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2079—Filtering means
    • A61J1/2086—Filtering means for fluid filtration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3123—Details having air entrapping or venting means, e.g. purging channels in pistons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/02—Access sites
    • A61M39/04—Access sites having pierceable self-sealing members
    • A61M2039/042—Shrouds encircling the access needle preventing accidental needle-stick

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

본 발명은, 하나는 파우더, 리오필리사이트 또는 액체의 형태이고, 다른 하나는 희석제 또는 액체 용매인 두가지 성분으로부터 약체 용액을 제조하기 위한 장치에 관한 것이다. 이러한 화합물은 각각, 축으로 이동가능한 밀폐 장치-피스톤-밸브에 의해 폐쇄되는 개방을 가지고, 말단이 폐쇄된 용기(11) 및 인접 용기(13)에 저장된다. 본 장치가 저자 위치에 있을 때, 두 개의 밀폐 장치-피스톤-밸브(19, 24)사이의 고정되고, 폐쇄되고, 살균된 연결된 결합을 제공하고, 본 장치가 사용 위치에 있을 때, 두 용기(11, 13)사이에 액체-압박되고, 살균된 전달 채널을 한정하도록 배열된 로드(15)에 의해 상기 두 개의 밀폐 장치-피스톤-밸브(19, 24)가 연결된다. 밀폐 장치-피스톤-밸브(19, 24)는, 본 장치가 저장 위치에 있을 때, 매우 압박되고, 폐쇄되고, 이동로드(15)의 끝이 삽입되어 본 장치가 사용 위치에 있을 때, 개방되는 슬롯(31, 33)으로 제공되는 중앙 지역을 가진다.

Description

의학 물질의 요액, 현탁액 또는 에멀션의 제제를 위한 장치(DEVICE FOR THE PREPARATION OF A SOLUTION, A SUSPENSION OR AN EMULSION OF A MEDICINAL SUBSTANCE)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1내지 4도는 충전, 사용하기 위한 접속 및 사용의 연속적 단계를 나타내는, 본 발명에 따른 장치의 구조의 유리한 구체예를 도시한 도면,
제5도는 눈 적제 투여기로서의 사용을 위한 본 장치의 구조의 특수한 구체예를 도시한 도면.

Claims (12)

  1. 2가지 성분을 사용하여 활성 의약물질로부터 용액, 현탁액 또는 유탁액을 제조하는 장치로서, 분말형태의 제1성분을 동결건조물, 액체 또는 페이스트 상태로 함유하고 있으며 전방 용기(13)보다 높은 위치에 배치된 후방 용기(11); 희석제나 액체 용매(14)를 제2성분으로 함유하고 있는 전방 용기(13); 상기 2개의 용기를 운반축(15)과 함께 연결시키는 역할을 하고, 상기 후방 용기(11)의 마개-피스톤-디쉬(19)의 높이가 상기 전방용기(13)의 마개-피스톤-디쉬(24)보다 높게 설정되어 있으며, 중심 영역에 슬릿(31, 33)이 형성되어 있어서, 상기 장치가 적재 상태일 때는 강력하게 가압 및 밀폐되고 이동축(15)의 한 쪽 단부가 상기 슬릿내로 도입되어 상기 장치가 제2위치에 있을 때는 개방되도록 하는 작용을 하는 마개-피스톤-디쉬(19, 24); 및 자체의 단부가 상기 용기들의 장축 방향과 직각인 평면에 있도록 형상화되어 있는 이동축(15)으로 구성되고, 상기 장치는 바닥부(17)가 폐쇄된 1개의 후방 용기 및 다른1개의 전방 용기(11)로 이루어진 2개의 긴 용기에, 분말 형태, 동결건조 형태, 액체 또는 페이스트 형태의 제1성분과 희석제 또는 액체 용매 형태의 제2성분이 각각 충전 또는 저장되어 있으며, 상기 용기는 각각 운반 축(15)에 의해 함께 연결되어 있는 마개-피스톤-디쉬(19, 24)에 의해 용기내에서 축방향으로 이동이 가능한 방식으로 자체의 한 쪽 단부의 개구부가 폐쇠되어 있고, 상기 이동 축(15)은 상기 장치가 충전 또는 저장중인 제1위치에 있을 때에는 마게-피스톤-디쉬(19, 24)사이에 견고한 밀봉식 무균적 결합을 제공하도록 배치되고, 상기 장치가 사용할 때의 제2위치에 있을 때에는 상기 2개용기들 사이에 견고한 무균적 연결 통로를 확보할 수 있도록 되어 있는, 2가지 성분을 사용하여 활성의약물질로부터 용액, 현탁액 또는 유탁액을 제조하는 장치.
  2. 제1항에 있어서, 전방 용기(13), 및 후방 용기(11)의 일부 이상이 배치되는 슬리브(60)를 구비하는 것을 특징으로 하는 장치.
  3. 제2항에 있어서, 슬리브(60)가, 컵(70) 및 다중 투여 방식의 적용을 위한 장치(71)에 연결되는 것을 특징으로 하는 장치.
  4. 제2항에 있어서, 슬리브(60)가, 전방용기(13)에 일체화되어 있는 것을 특징으로 하는 장치.
  5. 제2항에 있어서, 슬리브(60)가, 전방용기(13)에 일체화된, 눈점적 도찰장치 또는 비강훈증기로 이루어진 페룰이 제공되는 것을 특징으로 하는 장치.
  6. 제2항에 있어서, 슬리브가, 서로 꼭 맞는 제1관형 부재(40) 및 제2관형 요소(42)가 포함되고, 상기 제1관형 부재에는 전방 용기(12)가 포함되고, 제2부재에서 후방 용기(11)가 포함되어 있는 것을 특징으로 하는 장치.
  7. 제6항에 있어서, 제1관형 부재는 단편(43)을 가지고, 제2관형 부재는 상기 단편들과 합동 작용하도록배열되어있는 2개 이상의 혀모양의 스트립(44)을 가지는 것을 특징으로 하는 장치.
  8. 제1항에 있어서, 마개-피스톤-디쉬(19, 24)가 각각 중앙 슬릿(32, 26)을 가지고, 운반 축(15)이 마개-피스톤-디쉬(19, 24)에 밀봉식 무균수단을 가지는 것을 특징으로 하는 방법.
  9. 제1항에 있어서, 장치를 사용중일 때, 운반 축(15)이, 마개-피스톤-디쉬에 대하여 표면들을 지지하도록 배열되는 정지 접촉부를 가지는 것을 특징으로 하는 장치.
  10. 제1항에 있어서, 상기 전방 및 후방 용기(11, 13)를 독립적으로 충전 및 취급하는 방식으로 상기 용기의 내측을 지지함으로써, 마개-피스톤-디쉬(19, 24)에서 관련 용기(11, 13)의 기밀식 무균 폐쇄를 보장하도록 되어 있는 것을 특징으로 하는 장치.
  11. 제1항에 있어서, 운반 축(15)이, 후방용기(11) 및 전방용기(13)와 상호 의존적으로 제조된 마개-피스톤-디쉬(19, 24)의 견실한 기밀식 무균 결합을 보장하도록 되어 있는 것을 특징으로 하는 장치.
  12. 제1항에 있어서, 전방 용기(13)가, 요구되는 치료학적 용도에서 기능하는 상이한 페룰 및 도포기를 수용할 수 있도록 되어 있는 것을 특징으로 하는 장치.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019960700447A 1994-05-25 1994-05-24 의학 물질의 용액, 현탁액 또는 에멀션의 제제를 위한 장치(device for the preparation fo a solution. a suspension or an emulsion of a medicinal substance) Withdrawn KR960704591A (ko)

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PCT/CH1994/000097 WO1995032015A1 (fr) 1994-05-25 1994-05-25 Dispositif pour la preparation d'une solution, d'une suspension ou d'une emulsion d'une substance medicinale

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KR (1) KR960704591A (ko)
AU (1) AU6643994A (ko)
CZ (1) CZ31996A3 (ko)
FI (1) FI960320A7 (ko)
NO (1) NO960286L (ko)
SK (1) SK22896A3 (ko)
WO (1) WO1995032015A1 (ko)

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Publication number Publication date
NO960286D0 (no) 1996-01-24
SK22896A3 (en) 1996-10-02
NO960286L (no) 1996-01-24
FI960320A7 (fi) 1996-03-11
CZ31996A3 (en) 1996-05-15
FI960320A0 (fi) 1996-01-24
WO1995032015A1 (fr) 1995-11-30
AU6643994A (en) 1995-12-18

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