WO2004103996A1 - Hepatitis c inhibitor compounds - Google Patents

Hepatitis c inhibitor compounds Download PDF

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Publication number
WO2004103996A1
WO2004103996A1 PCT/CA2004/000750 CA2004000750W WO2004103996A1 WO 2004103996 A1 WO2004103996 A1 WO 2004103996A1 CA 2004000750 W CA2004000750 W CA 2004000750W WO 2004103996 A1 WO2004103996 A1 WO 2004103996A1
Authority
WO
WIPO (PCT)
Prior art keywords
alkyl
cycloalkyl
compound according
substituted
compound
Prior art date
Application number
PCT/CA2004/000750
Other languages
English (en)
French (fr)
Inventor
Montse Llinas-Brunet
Murray D. Bailey
Punit Bhardwaj
Josée BORDELEAU
Pasquale Forgione
Elise Ghiro
Vida Gorys
Nathalie Goudreau
Sylvie Goulet
Teddy Halmos
Jean Rancourt
Original Assignee
Boehringer Ingelheim International Gmbh
Boehringer Ingelheim Pharma Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33476973&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2004103996(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to CA2522577A priority Critical patent/CA2522577C/en
Priority to KR1020057022088A priority patent/KR101115294B1/ko
Priority to EA200501689A priority patent/EA009295B1/ru
Priority to DK04733750T priority patent/DK1654261T3/da
Priority to PL04733750T priority patent/PL1654261T3/pl
Priority to AU2004240704A priority patent/AU2004240704B9/en
Priority to DE602004010137T priority patent/DE602004010137T2/de
Priority to JP2006529495A priority patent/JP4447603B2/ja
Priority to MXPA05012545A priority patent/MXPA05012545A/es
Priority to YUP-2005/0871A priority patent/RS51294B/sr
Priority to BRPI0410456A priority patent/BRPI0410456B8/pt
Priority to MEP-583/08A priority patent/MEP58308A/xx
Priority to EP04733750A priority patent/EP1654261B1/en
Priority to NZ544076A priority patent/NZ544076A/en
Priority to SI200430588T priority patent/SI1654261T1/sl
Application filed by Boehringer Ingelheim International Gmbh, Boehringer Ingelheim Pharma Gmbh & Co Kg filed Critical Boehringer Ingelheim International Gmbh
Publication of WO2004103996A1 publication Critical patent/WO2004103996A1/en
Priority to IL172013A priority patent/IL172013A/en
Priority to NO20056047A priority patent/NO332056B1/no
Priority to HR20080014T priority patent/HRP20080014T3/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Zoology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PCT/CA2004/000750 2003-05-21 2004-05-19 Hepatitis c inhibitor compounds WO2004103996A1 (en)

Priority Applications (18)

Application Number Priority Date Filing Date Title
MXPA05012545A MXPA05012545A (es) 2003-05-21 2004-05-19 Compuestos inhibidores de la hepatitis c.
NZ544076A NZ544076A (en) 2003-05-21 2004-05-19 Hepatitis C inhibitor compounds
EA200501689A EA009295B1 (ru) 2003-05-21 2004-05-19 Соединения в качестве ингибиторов вируса гепатита с
DK04733750T DK1654261T3 (da) 2003-05-21 2004-05-19 Hepatitis C-inhibitorforbindelser
PL04733750T PL1654261T3 (pl) 2003-05-21 2004-05-19 Związki hamujące aktywność wirusa zapalenia wątroby typu C
AU2004240704A AU2004240704B9 (en) 2003-05-21 2004-05-19 Hepatitis C inhibitor compounds
DE602004010137T DE602004010137T2 (de) 2003-05-21 2004-05-19 Verbindungen als hepatitis c inhibitoren
BRPI0410456A BRPI0410456B8 (pt) 2003-05-21 2004-05-19 compostos inibidores de hepatite c, composição farmacêutica, uso dos mesmos, bem como artigo de fabricação
YUP-2005/0871A RS51294B (sr) 2003-05-21 2004-05-19 Inhibitorna jedinjenja za hepatitis c
CA2522577A CA2522577C (en) 2003-05-21 2004-05-19 Hepatitis c inhibitor compounds
JP2006529495A JP4447603B2 (ja) 2003-05-21 2004-05-19 Ｃ型肝炎インヒビター化合物
MEP-583/08A MEP58308A (en) 2003-05-21 2004-05-19 Hepatitis c inhibitor compounds
EP04733750A EP1654261B1 (en) 2003-05-21 2004-05-19 Hepatitis c inhibitor compounds
KR1020057022088A KR101115294B1 (ko) 2003-05-21 2004-05-19 Ｃ형 간염 억제제 화합물
SI200430588T SI1654261T1 (sl) 2003-05-21 2004-05-19 Inhibitorske spojine hepatitisa C
IL172013A IL172013A (en) 2003-05-21 2005-11-17 Hepatitis C-inhibiting compounds and pharmaceutical preparations containing them
NO20056047A NO332056B1 (no) 2003-05-21 2005-12-19 Hepatitt C inhibitor-forbindelser, farmasoytisk preparat inneholdende slike samt slike forbindelser for behandling av sykdom
HR20080014T HRP20080014T3 (en) 2003-05-21 2008-01-11 Hepatitis c inhibitor compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47270903P 2003-05-21 2003-05-21
US60/472,709 2003-05-21

Publications (1)

Publication Number Publication Date
WO2004103996A1 true WO2004103996A1 (en) 2004-12-02

Family

ID=33476973

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2004/000750 WO2004103996A1 (en) 2003-05-21 2004-05-19 Hepatitis c inhibitor compounds

Country Status (33)

Country Link
US (5) US7585845B2 (US08067438-20111129-C00451.png)
EP (1) EP1654261B1 (US08067438-20111129-C00451.png)
JP (2) JP4447603B2 (US08067438-20111129-C00451.png)
KR (1) KR101115294B1 (US08067438-20111129-C00451.png)
CN (3) CN103203010A (US08067438-20111129-C00451.png)
AT (1) ATE378334T1 (US08067438-20111129-C00451.png)
AU (1) AU2004240704B9 (US08067438-20111129-C00451.png)
BR (1) BRPI0410456B8 (US08067438-20111129-C00451.png)
CA (1) CA2522577C (US08067438-20111129-C00451.png)
CL (1) CL2004001161A1 (US08067438-20111129-C00451.png)
CO (1) CO5630024A2 (US08067438-20111129-C00451.png)
CY (1) CY1107200T1 (US08067438-20111129-C00451.png)
DE (1) DE602004010137T2 (US08067438-20111129-C00451.png)
DK (1) DK1654261T3 (US08067438-20111129-C00451.png)
EA (1) EA009295B1 (US08067438-20111129-C00451.png)
EC (1) ECSP056181A (US08067438-20111129-C00451.png)
ES (1) ES2297424T3 (US08067438-20111129-C00451.png)
HR (1) HRP20080014T3 (US08067438-20111129-C00451.png)
IL (1) IL172013A (US08067438-20111129-C00451.png)
ME (1) MEP58308A (US08067438-20111129-C00451.png)
MX (1) MXPA05012545A (US08067438-20111129-C00451.png)
MY (1) MY143076A (US08067438-20111129-C00451.png)
NO (1) NO332056B1 (US08067438-20111129-C00451.png)
NZ (1) NZ544076A (US08067438-20111129-C00451.png)
PE (1) PE20050204A1 (US08067438-20111129-C00451.png)
PL (1) PL1654261T3 (US08067438-20111129-C00451.png)
PT (1) PT1654261E (US08067438-20111129-C00451.png)
RS (1) RS51294B (US08067438-20111129-C00451.png)
TW (1) TWI327145B (US08067438-20111129-C00451.png)
UA (1) UA83046C2 (US08067438-20111129-C00451.png)
UY (1) UY28323A1 (US08067438-20111129-C00451.png)
WO (1) WO2004103996A1 (US08067438-20111129-C00451.png)
ZA (1) ZA200508201B (US08067438-20111129-C00451.png)

Cited By (109)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005080388A1 (en) 2004-02-20 2005-09-01 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
WO2005116054A1 (en) * 2004-05-25 2005-12-08 Boehringer Ingelheim International, Gmbh Process for preparing acyclic hcv protease inhibitors
WO2006007700A1 (en) * 2004-07-20 2006-01-26 Boehringer Ingelheim International Gmbh Hepatitis c inhibitor dipeptide analogs
WO2007005838A2 (en) 2005-06-30 2007-01-11 Virobay, Inc. Hcv inhibitors
WO2007019674A1 (en) 2005-08-12 2007-02-22 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
EP1763531A1 (en) * 2004-06-28 2007-03-21 Boehringer Ingelheim International Gmbh Hepatitis c inhibitor peptide analogs
WO2007009109A3 (en) * 2005-07-14 2007-06-07 Gilead Sciences Inc Antiviral compounds
US7323447B2 (en) 2005-02-08 2008-01-29 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7368452B2 (en) 2003-04-18 2008-05-06 Enanta Pharmaceuticals, Inc. Quinoxalinyl macrocyclic hepatitis C serine protease inhibitors
WO2008057209A1 (en) * 2006-10-27 2008-05-15 Merck & Co., Inc. Hcv ns3 protease inhibitors
WO2008070358A2 (en) * 2006-11-16 2008-06-12 Phenomix Corporation N-cyclopropyl-hydroxyproline-based tripeptidic hepatitis c serine protease inhibitors containing an isoindole, pyrrolopyridine, pyrrolopyrimidine or pyrrolopyrazine heterocycle in the side chain
US7449479B2 (en) 2002-05-20 2008-11-11 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
WO2009076173A2 (en) 2007-12-05 2009-06-18 Enanta Pharmaceuticals, Inc. Fluorinated tripeptide hcv serine protease inhibitors
WO2009076747A1 (en) 2007-12-19 2009-06-25 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
EP2079480A2 (en) * 2006-10-24 2009-07-22 Merck & Co., Inc. Hcv ns3 protease inhibitors
US7592336B2 (en) 2005-05-10 2009-09-22 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7601686B2 (en) 2005-07-11 2009-10-13 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7608590B2 (en) 2004-01-30 2009-10-27 Medivir Ab HCV NS-3 serine protease inhibitors
WO2010033444A1 (en) * 2008-09-16 2010-03-25 Boehringer Ingelheim International Gmbh Crystalline forms of a 2-thiazolyl- 4-quinolinyl-oxy derivative, a potent hcv inhibitor
WO2010033443A1 (en) * 2008-09-17 2010-03-25 Boehringer Ingelheim International Gmbh Combination of hcv ns3 protease inhibitor with interferon and ribavirin
US7696242B2 (en) 2004-07-20 2010-04-13 Boehringer Ingelheim International Gmbh Hepatitis C inhibitor peptide analogs
US7718612B2 (en) * 2007-08-02 2010-05-18 Enanta Pharmaceuticals, Inc. Pyridazinonyl macrocyclic hepatitis C serine protease inhibitors
WO2010059667A1 (en) * 2008-11-21 2010-05-27 Boehringer Ingelheim International Gmbh Pharmaceutical composition of a potent hcv inhibitor for oral administration
US7741281B2 (en) 2005-11-03 2010-06-22 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
WO2010080874A1 (en) 2009-01-07 2010-07-15 Scynexis, Inc. Cyclosporine derivative for use in the treatment of hcv and hiv infection
US7763584B2 (en) 2006-11-16 2010-07-27 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7767660B2 (en) 2006-12-20 2010-08-03 Istituto Di Richerche Di Biologia Molecolare P. Angeletti Spa Antiviral indoles
US7772180B2 (en) 2006-11-09 2010-08-10 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7772183B2 (en) 2005-10-12 2010-08-10 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7781422B2 (en) 2006-12-20 2010-08-24 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa Antiviral indoles
US7816348B2 (en) 2006-02-03 2010-10-19 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
WO2010132163A1 (en) 2009-05-13 2010-11-18 Enanta Pharmaceuticals, Inc. Macrocyclic compounds as hepatitis c virus inhibitors
US7879797B2 (en) 2005-05-02 2011-02-01 Merck Sharp & Dohme Corp. HCV NS3 protease inhibitors
US7888464B2 (en) 2006-11-16 2011-02-15 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7897622B2 (en) 2006-08-17 2011-03-01 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7906619B2 (en) 2006-07-13 2011-03-15 Achillion Pharmaceuticals, Inc. 4-amino-4-oxobutanoyl peptides as inhibitors of viral replication
US7935670B2 (en) 2006-07-11 2011-05-03 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7939667B2 (en) 2003-05-21 2011-05-10 Boehringer Ingelheim International Gmbh Hepatitis C inhibitor compounds
US7964560B2 (en) 2008-05-29 2011-06-21 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7973040B2 (en) 2008-07-22 2011-07-05 Merck Sharp & Dohme Corp. Macrocyclic quinoxaline compounds as HCV NS3 protease inhibitors
US7989438B2 (en) 2007-07-17 2011-08-02 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa Therapeutic compounds
US8003604B2 (en) 2006-11-16 2011-08-23 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
EP2361925A1 (en) * 2003-10-10 2011-08-31 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
EP2364984A1 (en) 2005-08-26 2011-09-14 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases
US8044023B2 (en) 2008-05-29 2011-10-25 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8044087B2 (en) 2008-09-29 2011-10-25 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
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US8138164B2 (en) 2006-10-24 2012-03-20 Merck Sharp & Dohme Corp. HCV NS3 protease inhibitors
US8148399B2 (en) 2005-07-29 2012-04-03 Tibotec Pharmaceuticals Ltd. Macrocyclic inhibitors of hepatitis C virus
US8163693B2 (en) 2007-09-24 2012-04-24 Achillion Pharmaceuticals, Inc. Urea-containing peptides as inhibitors of viral replication
US8163921B2 (en) 2008-04-16 2012-04-24 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8178520B2 (en) 2006-05-15 2012-05-15 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa Macrocyclic compounds as antiviral agents
US8178491B2 (en) 2007-06-29 2012-05-15 Gilead Sciences, Inc. Antiviral compounds
KR20120059481A (ko) * 2009-07-07 2012-06-08 베링거 인겔하임 인터내셔날 게엠베하 Ｃ형 간염 바이러스 프로테아제 억제제를 위한 약제학적 조성물
US8202996B2 (en) 2007-12-21 2012-06-19 Bristol-Myers Squibb Company Crystalline forms of N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N- ((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide
US8207341B2 (en) 2008-09-04 2012-06-26 Bristol-Myers Squibb Company Process or synthesizing substituted isoquinolines
US8216999B2 (en) 2005-07-20 2012-07-10 Merck Sharp & Dohme Corp. HCV NS3 protease inhibitors
US8242140B2 (en) 2007-08-03 2012-08-14 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
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US8278322B2 (en) 2005-08-01 2012-10-02 Merck Sharp & Dohme Corp. HCV NS3 protease inhibitors
US8283310B2 (en) 2008-12-15 2012-10-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
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US8377873B2 (en) 2006-10-24 2013-02-19 Merck Sharp & Dohme Corp. HCV NS3 protease inhibitors
US8377874B2 (en) 2006-10-27 2013-02-19 Merck Sharp & Dohme Corp. HCV NS3 protease inhibitors
US8420596B2 (en) 2008-09-11 2013-04-16 Abbott Laboratories Macrocyclic hepatitis C serine protease inhibitors
US8435984B2 (en) 2007-02-26 2013-05-07 Achillion Pharmaceuticals, Inc. Tertiary amine substituted peptides useful as inhibitors of HCV replication
US8461107B2 (en) 2008-04-28 2013-06-11 Merck Sharp & Dohme Corp. HCV NS3 protease inhibitors
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