WO2004103996A1 - Hepatitis c inhibitor compounds - Google Patents
Hepatitis c inhibitor compounds Download PDFInfo
- Publication number
- WO2004103996A1 WO2004103996A1 PCT/CA2004/000750 CA2004000750W WO2004103996A1 WO 2004103996 A1 WO2004103996 A1 WO 2004103996A1 CA 2004000750 W CA2004000750 W CA 2004000750W WO 2004103996 A1 WO2004103996 A1 WO 2004103996A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- alkyl
- cycloalkyl
- compound according
- substituted
- compound
- Prior art date
Links
- 0 Cc(c(OC)ccc1)c1NC(C(OC)=O)=C* Chemical compound Cc(c(OC)ccc1)c1NC(C(OC)=O)=C* 0.000 description 6
- GALLMPFNVWUCGD-INEUFUBQSA-N C=C[C@H](C1)[C@]1(C(O)=O)N Chemical compound C=C[C@H](C1)[C@]1(C(O)=O)N GALLMPFNVWUCGD-INEUFUBQSA-N 0.000 description 1
- BJNJKOKPKYNBHD-UHFFFAOYSA-N CC(C)C1COCC1 Chemical compound CC(C)C1COCC1 BJNJKOKPKYNBHD-UHFFFAOYSA-N 0.000 description 1
- LCYIDKYBMDQDOZ-IWTSBMLOSA-N CC(C)Nc1nc(-c2nc(cc(c(OCCC(C)(C)[C@@H](C(N(CCC3)C3C(N[C@](C3)(C3C=C)C(O)=O)=O)=O)NC(OC3CCCC3)=O)c3)OC)c3c(O)c2)c[s]1 Chemical compound CC(C)Nc1nc(-c2nc(cc(c(OCCC(C)(C)[C@@H](C(N(CCC3)C3C(N[C@](C3)(C3C=C)C(O)=O)=O)=O)NC(OC3CCCC3)=O)c3)OC)c3c(O)c2)c[s]1 LCYIDKYBMDQDOZ-IWTSBMLOSA-N 0.000 description 1
- VZPWDIDCIACBOM-UHFFFAOYSA-N CCC1(C)COCOC1 Chemical compound CCC1(C)COCOC1 VZPWDIDCIACBOM-UHFFFAOYSA-N 0.000 description 1
- SDUMAMAOIIPHHC-GVHPTDIKSA-N CCc1nc(-c2cc(O[C@H](C[C@H]3C(N[C@](C4)(C4C=[O]4)C4=O)=O)CN3C(C(C(C)(C)C)NC(NC3CCCC3)=O)=O)c(ccc(OC)c3C)c3n2)c[s]1 Chemical compound CCc1nc(-c2cc(O[C@H](C[C@H]3C(N[C@](C4)(C4C=[O]4)C4=O)=O)CN3C(C(C(C)(C)C)NC(NC3CCCC3)=O)=O)c(ccc(OC)c3C)c3n2)c[s]1 SDUMAMAOIIPHHC-GVHPTDIKSA-N 0.000 description 1
- LVXQPSXJHNIWRE-CSKARUKUSA-N COC(/C=C(\C(OC)=O)/Nc(cccc1)c1OC)=O Chemical compound COC(/C=C(\C(OC)=O)/Nc(cccc1)c1OC)=O LVXQPSXJHNIWRE-CSKARUKUSA-N 0.000 description 1
- JFWIAQNNAPXWLS-UHFFFAOYSA-N COC(c1nc(c(OC)ccc2)c2c(O)c1)=O Chemical compound COC(c1nc(c(OC)ccc2)c2c(O)c1)=O JFWIAQNNAPXWLS-UHFFFAOYSA-N 0.000 description 1
- LIKRVBALRTXTPS-UHFFFAOYSA-N Cc(c(OC)c1)cc(c(O)c2)c1nc2C(OC)=O Chemical compound Cc(c(OC)c1)cc(c(O)c2)c1nc2C(OC)=O LIKRVBALRTXTPS-UHFFFAOYSA-N 0.000 description 1
- XCQBWOYLMVFXLP-DHZHZOJOSA-N Cc(c(OC)c1)ccc1N/C(/C(OC)=O)=C/C(OC)=O Chemical compound Cc(c(OC)c1)ccc1N/C(/C(OC)=O)=C/C(OC)=O XCQBWOYLMVFXLP-DHZHZOJOSA-N 0.000 description 1
- OPXLVWLFDKRYRB-UHFFFAOYSA-N Cc(c(OC)ccc1)c1N Chemical compound Cc(c(OC)ccc1)c1N OPXLVWLFDKRYRB-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/212—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Zoology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Priority Applications (18)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MXPA05012545A MXPA05012545A (es) | 2003-05-21 | 2004-05-19 | Compuestos inhibidores de la hepatitis c. |
NZ544076A NZ544076A (en) | 2003-05-21 | 2004-05-19 | Hepatitis C inhibitor compounds |
EA200501689A EA009295B1 (ru) | 2003-05-21 | 2004-05-19 | Соединения в качестве ингибиторов вируса гепатита с |
DK04733750T DK1654261T3 (da) | 2003-05-21 | 2004-05-19 | Hepatitis C-inhibitorforbindelser |
PL04733750T PL1654261T3 (pl) | 2003-05-21 | 2004-05-19 | Związki hamujące aktywność wirusa zapalenia wątroby typu C |
AU2004240704A AU2004240704B9 (en) | 2003-05-21 | 2004-05-19 | Hepatitis C inhibitor compounds |
DE602004010137T DE602004010137T2 (de) | 2003-05-21 | 2004-05-19 | Verbindungen als hepatitis c inhibitoren |
BRPI0410456A BRPI0410456B8 (pt) | 2003-05-21 | 2004-05-19 | compostos inibidores de hepatite c, composição farmacêutica, uso dos mesmos, bem como artigo de fabricação |
YUP-2005/0871A RS51294B (sr) | 2003-05-21 | 2004-05-19 | Inhibitorna jedinjenja za hepatitis c |
CA2522577A CA2522577C (en) | 2003-05-21 | 2004-05-19 | Hepatitis c inhibitor compounds |
JP2006529495A JP4447603B2 (ja) | 2003-05-21 | 2004-05-19 | C型肝炎インヒビター化合物 |
MEP-583/08A MEP58308A (en) | 2003-05-21 | 2004-05-19 | Hepatitis c inhibitor compounds |
EP04733750A EP1654261B1 (en) | 2003-05-21 | 2004-05-19 | Hepatitis c inhibitor compounds |
KR1020057022088A KR101115294B1 (ko) | 2003-05-21 | 2004-05-19 | C형 간염 억제제 화합물 |
SI200430588T SI1654261T1 (sl) | 2003-05-21 | 2004-05-19 | Inhibitorske spojine hepatitisa C |
IL172013A IL172013A (en) | 2003-05-21 | 2005-11-17 | Hepatitis C-inhibiting compounds and pharmaceutical preparations containing them |
NO20056047A NO332056B1 (no) | 2003-05-21 | 2005-12-19 | Hepatitt C inhibitor-forbindelser, farmasoytisk preparat inneholdende slike samt slike forbindelser for behandling av sykdom |
HR20080014T HRP20080014T3 (en) | 2003-05-21 | 2008-01-11 | Hepatitis c inhibitor compounds |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US47270903P | 2003-05-21 | 2003-05-21 | |
US60/472,709 | 2003-05-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2004103996A1 true WO2004103996A1 (en) | 2004-12-02 |
Family
ID=33476973
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CA2004/000750 WO2004103996A1 (en) | 2003-05-21 | 2004-05-19 | Hepatitis c inhibitor compounds |
Country Status (33)
Cited By (109)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005080388A1 (en) | 2004-02-20 | 2005-09-01 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
WO2005116054A1 (en) * | 2004-05-25 | 2005-12-08 | Boehringer Ingelheim International, Gmbh | Process for preparing acyclic hcv protease inhibitors |
WO2006007700A1 (en) * | 2004-07-20 | 2006-01-26 | Boehringer Ingelheim International Gmbh | Hepatitis c inhibitor dipeptide analogs |
WO2007005838A2 (en) | 2005-06-30 | 2007-01-11 | Virobay, Inc. | Hcv inhibitors |
WO2007019674A1 (en) | 2005-08-12 | 2007-02-22 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
EP1763531A1 (en) * | 2004-06-28 | 2007-03-21 | Boehringer Ingelheim International Gmbh | Hepatitis c inhibitor peptide analogs |
WO2007009109A3 (en) * | 2005-07-14 | 2007-06-07 | Gilead Sciences Inc | Antiviral compounds |
US7323447B2 (en) | 2005-02-08 | 2008-01-29 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US7368452B2 (en) | 2003-04-18 | 2008-05-06 | Enanta Pharmaceuticals, Inc. | Quinoxalinyl macrocyclic hepatitis C serine protease inhibitors |
WO2008057209A1 (en) * | 2006-10-27 | 2008-05-15 | Merck & Co., Inc. | Hcv ns3 protease inhibitors |
WO2008070358A2 (en) * | 2006-11-16 | 2008-06-12 | Phenomix Corporation | N-cyclopropyl-hydroxyproline-based tripeptidic hepatitis c serine protease inhibitors containing an isoindole, pyrrolopyridine, pyrrolopyrimidine or pyrrolopyrazine heterocycle in the side chain |
US7449479B2 (en) | 2002-05-20 | 2008-11-11 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
WO2009076173A2 (en) | 2007-12-05 | 2009-06-18 | Enanta Pharmaceuticals, Inc. | Fluorinated tripeptide hcv serine protease inhibitors |
WO2009076747A1 (en) | 2007-12-19 | 2009-06-25 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
EP2079480A2 (en) * | 2006-10-24 | 2009-07-22 | Merck & Co., Inc. | Hcv ns3 protease inhibitors |
US7592336B2 (en) | 2005-05-10 | 2009-09-22 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US7601686B2 (en) | 2005-07-11 | 2009-10-13 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US7608590B2 (en) | 2004-01-30 | 2009-10-27 | Medivir Ab | HCV NS-3 serine protease inhibitors |
WO2010033444A1 (en) * | 2008-09-16 | 2010-03-25 | Boehringer Ingelheim International Gmbh | Crystalline forms of a 2-thiazolyl- 4-quinolinyl-oxy derivative, a potent hcv inhibitor |
WO2010033443A1 (en) * | 2008-09-17 | 2010-03-25 | Boehringer Ingelheim International Gmbh | Combination of hcv ns3 protease inhibitor with interferon and ribavirin |
US7696242B2 (en) | 2004-07-20 | 2010-04-13 | Boehringer Ingelheim International Gmbh | Hepatitis C inhibitor peptide analogs |
US7718612B2 (en) * | 2007-08-02 | 2010-05-18 | Enanta Pharmaceuticals, Inc. | Pyridazinonyl macrocyclic hepatitis C serine protease inhibitors |
WO2010059667A1 (en) * | 2008-11-21 | 2010-05-27 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition of a potent hcv inhibitor for oral administration |
US7741281B2 (en) | 2005-11-03 | 2010-06-22 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
WO2010080874A1 (en) | 2009-01-07 | 2010-07-15 | Scynexis, Inc. | Cyclosporine derivative for use in the treatment of hcv and hiv infection |
US7763584B2 (en) | 2006-11-16 | 2010-07-27 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US7767660B2 (en) | 2006-12-20 | 2010-08-03 | Istituto Di Richerche Di Biologia Molecolare P. Angeletti Spa | Antiviral indoles |
US7772180B2 (en) | 2006-11-09 | 2010-08-10 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US7772183B2 (en) | 2005-10-12 | 2010-08-10 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US7781422B2 (en) | 2006-12-20 | 2010-08-24 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa | Antiviral indoles |
US7816348B2 (en) | 2006-02-03 | 2010-10-19 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
WO2010132163A1 (en) | 2009-05-13 | 2010-11-18 | Enanta Pharmaceuticals, Inc. | Macrocyclic compounds as hepatitis c virus inhibitors |
US7879797B2 (en) | 2005-05-02 | 2011-02-01 | Merck Sharp & Dohme Corp. | HCV NS3 protease inhibitors |
US7888464B2 (en) | 2006-11-16 | 2011-02-15 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US7897622B2 (en) | 2006-08-17 | 2011-03-01 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
US7906619B2 (en) | 2006-07-13 | 2011-03-15 | Achillion Pharmaceuticals, Inc. | 4-amino-4-oxobutanoyl peptides as inhibitors of viral replication |
US7935670B2 (en) | 2006-07-11 | 2011-05-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US7939667B2 (en) | 2003-05-21 | 2011-05-10 | Boehringer Ingelheim International Gmbh | Hepatitis C inhibitor compounds |
US7964560B2 (en) | 2008-05-29 | 2011-06-21 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US7973040B2 (en) | 2008-07-22 | 2011-07-05 | Merck Sharp & Dohme Corp. | Macrocyclic quinoxaline compounds as HCV NS3 protease inhibitors |
US7989438B2 (en) | 2007-07-17 | 2011-08-02 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa | Therapeutic compounds |
US8003604B2 (en) | 2006-11-16 | 2011-08-23 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
EP2361925A1 (en) * | 2003-10-10 | 2011-08-31 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases, particularly HCV NS3-NS4A protease |
EP2364984A1 (en) | 2005-08-26 | 2011-09-14 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
US8044023B2 (en) | 2008-05-29 | 2011-10-25 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US8044087B2 (en) | 2008-09-29 | 2011-10-25 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
EP2399988A2 (en) | 2006-08-11 | 2011-12-28 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Cell culture system for replication of HCV through the farnesoid X receptor (FXR) activation or inhibition and diagnostic method for HCV infection |
US8101595B2 (en) | 2006-12-20 | 2012-01-24 | Istituto di Ricerche di Biologia Molecolare P. Angletti SpA | Antiviral indoles |
US20120059033A1 (en) * | 2010-03-11 | 2012-03-08 | Boehringer Ingelheim International Gmbh | Crystalline Salts of a Potent HCV Inhibitor |
US8138164B2 (en) | 2006-10-24 | 2012-03-20 | Merck Sharp & Dohme Corp. | HCV NS3 protease inhibitors |
US8148399B2 (en) | 2005-07-29 | 2012-04-03 | Tibotec Pharmaceuticals Ltd. | Macrocyclic inhibitors of hepatitis C virus |
US8163693B2 (en) | 2007-09-24 | 2012-04-24 | Achillion Pharmaceuticals, Inc. | Urea-containing peptides as inhibitors of viral replication |
US8163921B2 (en) | 2008-04-16 | 2012-04-24 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US8178520B2 (en) | 2006-05-15 | 2012-05-15 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa | Macrocyclic compounds as antiviral agents |
US8178491B2 (en) | 2007-06-29 | 2012-05-15 | Gilead Sciences, Inc. | Antiviral compounds |
KR20120059481A (ko) * | 2009-07-07 | 2012-06-08 | 베링거 인겔하임 인터내셔날 게엠베하 | C형 간염 바이러스 프로테아제 억제제를 위한 약제학적 조성물 |
US8202996B2 (en) | 2007-12-21 | 2012-06-19 | Bristol-Myers Squibb Company | Crystalline forms of N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N- ((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide |
US8207341B2 (en) | 2008-09-04 | 2012-06-26 | Bristol-Myers Squibb Company | Process or synthesizing substituted isoquinolines |
US8216999B2 (en) | 2005-07-20 | 2012-07-10 | Merck Sharp & Dohme Corp. | HCV NS3 protease inhibitors |
US8242140B2 (en) | 2007-08-03 | 2012-08-14 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
WO2012107589A1 (en) | 2011-02-11 | 2012-08-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment and prevention of hcv infections |
US8278322B2 (en) | 2005-08-01 | 2012-10-02 | Merck Sharp & Dohme Corp. | HCV NS3 protease inhibitors |
US8283310B2 (en) | 2008-12-15 | 2012-10-09 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
EP2512477A1 (en) * | 2009-12-18 | 2012-10-24 | Boehringer Ingelheim International GmbH | Hcv combination therapy |
US8314141B2 (en) | 1996-10-18 | 2012-11-20 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases, particularly hepatitis C virus NS3 protease |
US8314062B2 (en) | 2006-06-23 | 2012-11-20 | Instituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Macrocyclic compounds as antiviral agents |
US8324417B2 (en) | 2009-08-19 | 2012-12-04 | Virobay, Inc. | Process for the preparation of (S)-2-amino-5-cyclopropyl-4,4-difluoropentanoic acid and alkyl esters and acid salts thereof |
US8343477B2 (en) | 2006-11-01 | 2013-01-01 | Bristol-Myers Squibb Company | Inhibitors of hepatitis C virus |
US8377873B2 (en) | 2006-10-24 | 2013-02-19 | Merck Sharp & Dohme Corp. | HCV NS3 protease inhibitors |
US8377874B2 (en) | 2006-10-27 | 2013-02-19 | Merck Sharp & Dohme Corp. | HCV NS3 protease inhibitors |
US8420596B2 (en) | 2008-09-11 | 2013-04-16 | Abbott Laboratories | Macrocyclic hepatitis C serine protease inhibitors |
US8435984B2 (en) | 2007-02-26 | 2013-05-07 | Achillion Pharmaceuticals, Inc. | Tertiary amine substituted peptides useful as inhibitors of HCV replication |
US8461107B2 (en) | 2008-04-28 | 2013-06-11 | Merck Sharp & Dohme Corp. | HCV NS3 protease inhibitors |
US8513186B2 (en) | 2007-06-29 | 2013-08-20 | Gilead Sciences, Inc. | Antiviral compounds |
EP2631238A1 (en) | 2007-02-27 | 2013-08-28 | Vertex Pharmaceuticals Incorporated | Spirocyclic inhibitors of serine proteases for the treatment of hcv infections |
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