US20060142373A1 - Medicaments for the Treatment or Prevention of Fibrotic Diseases - Google Patents

Medicaments for the Treatment or Prevention of Fibrotic Diseases Download PDF

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Publication number
US20060142373A1
US20060142373A1 US11/275,223 US27522305A US2006142373A1 US 20060142373 A1 US20060142373 A1 US 20060142373A1 US 27522305 A US27522305 A US 27522305A US 2006142373 A1 US2006142373 A1 US 2006142373A1
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United States
Prior art keywords
phenyl
methylene
indolinone
group
anilino
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Abandoned
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US11/275,223
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Inventor
John Park
Gerald Roth
Armin Heckel
Nveed Chaudhary
Trixi Brandl
Georg Dahmann
Matthias Grauert
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Boehringer Ingelheim International GmbH
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Boehringer Ingelheim International GmbH
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36602118&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=US20060142373(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim International GmbH filed Critical Boehringer Ingelheim International GmbH
Assigned to BOEHRINGER INGELHEIM INTERNATIONAL GMBH reassignment BOEHRINGER INGELHEIM INTERNATIONAL GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: GRAUERT, MATTHIAS, HECKEL, ARMIN, BRANDL, TRIXI, DAHMANN, GEORG, ROTH, GERALD JUERGEN, CHAUDHARY, NVEED, PARK, JOHN EDWARD
Publication of US20060142373A1 publication Critical patent/US20060142373A1/en
Priority to US12/645,151 priority Critical patent/US20100204211A1/en
Priority to US14/184,821 priority patent/US20140296217A1/en
Priority to US14/982,179 priority patent/US10154990B2/en
Priority to US16/167,567 priority patent/US20190038600A1/en
Priority to US16/921,043 priority patent/US20200330435A1/en
Priority to US18/363,779 priority patent/US20230372297A1/en
Abandoned legal-status Critical Current

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Definitions

  • the present invention relates to a new use of indolinones of general formula substituted in the 6 position, the tautomers, the diastereomers, the enantiomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof.
  • Remodeling is a normal response to tissue injury and inflammation that is observed in many tissues throughout the body. After resolution of the inflammation and repair of tissue damage, the tissue is generally returned to its original condition. Excessive uncontrolled tissue repair or the failure to stop remodeling when it is no longer required leads to condition known as fibrosis. Fibrosis is characterized by excessive deposition of extracellular matrix components and overgrowth of fibroblasts.
  • Fibrosis can occur in all tissues but is especially prevalent in organs with frequent exposure to chemical and biological insults including the lung, skin, digestive tract, kidney, and liver (Eddy, 1996, J Am Soc Nephrol, 7(12):2495-503; Dacic et al., 2003, Am J Respir Cell Mol Biol, 29S: S5-9; Wynn, 2004, Nat Rev Immunol, 4(8):583-94). Fibrosis often severely compromises the normal function(s) of the organ and many fibrotic diseases are, in fact, life-threatening or severely disfiguring, such as idiopathic pulmonary fibrosis (IPF), liver cirrhosis, scleroderma, or renal fibrosis. Treatment options for these diseases are often limited to organ transplantation, a risky and expensive procedure.
  • IPF idiopathic pulmonary fibrosis
  • PDGF platelet-derived growth factor
  • FGF fibroblast growth factor
  • VEGF vascular endothelial growth factor
  • EGF epidermal growth factor
  • TGFb transforming growth factor beta growth factor families in the induction or persistence of fibrosis
  • PDGF, EGF and FGF family members are potent mitogens for mesenchymal cells such as smooth muscle cells, myofibroblasts and fibroblasts (Benito et al., 1993, Growth Regul 3(3):172-9; Simm et al, 1998, Basic Res Cardiol, 93(S3):40-3; Klagsburn, Prog Growth Factor Res, 1989, 1(4):207-35; Kirkland et al., 1998, J Am Soc Nephrol, 9(8):1464-73), the very cells which supplant normal tissue in fibrosis and are believed to play a role in tissue remodeling (Abboud, 1995, Annu Rev Physiol., 57:297-309; Jinnin et al., 2004, J Cell Physiol, online; Martinet et al., 1996, Arch Toxicol 18:127-39; Desmouliere, Cell Biology International, 1995, 19:471-6; Jelaska et al., Springer Semin Immunopathol,
  • FGF1/FGF2-deficient mice show dramatically decreased liver fibrosis after chronic carbon tetrachloride (CCl4) exposure (Yu et al., 2003, Am J Pathol, 163(4):1653-62).
  • FGF expression is increased in human renal interstitial fibrosis where it strongly correlates with interstitial scarring (Strutz et al., 2000, Kidney Intl, 57:1521-38) as well as in a model of experimental lung fibrosis (Barrios et al., 1997, Am J Physiol, 273 (2 Pt 1):L451-8), again lending credence to the idea that fibrosis in various tissues has a common basis.
  • VEGF vascular endothelial growth factor
  • TGFb stimulates production of extracellular matrix proteins including fibronectin and collagens and is believed to play an important role in fibrosis in many tissues (Leask et al., 2004, FASEB J 18(7):816-27; Bartram et al., 2004, Chest 125(2):754-65; Strutz et al., 2003, Springer Semin Immunopathol, 24:459-76; Wynn, 2004, Nat Rev Immunol, 4(8):583-94). Inhibitors of TGFb production and signaling pathways are active in a number of fibrosis animal models (Wang et al., 2002, Exp Lung Res, 28:405-17; Laping, 2003, Curr Opin Pharmacol, 3(2):204-8).
  • the present invention thus relates to the use of the compounds of above general formula I for the preparation of a medicament for the treatment or prevention of specific fibrotic diseases.
  • the present invention also relates to a method for the treatment or prevention of specific fibrotic diseases, by administration to a patient in need thereof of a pharmaceutical composition comprising a compound of above general formula I, together with a pharmaceutically suitable carrier.
  • a pharmaceutical composition comprising a compound of above general formula I, together with a pharmaceutically suitable carrier.
  • patient is meant to comprise the mammalian animal body, preferably the human body.
  • the present invention further relates to a pharmaceutical composition for the treatment or prevention of specific fibrotic diseases which comprises a compound of above general formula I alone or in combination with one or more further therapeutic agents.
  • the compounds of above general formula I are the compounds in which
  • X denotes an oxygen or sulphur atom
  • R 1 denotes a hydrogen atom or a prodrug group such as a C 1-4 -alkoxycarbonyl or C 2-4 -alkanoyl group,
  • R 2 denotes a carboxy group, a straight-chain or branched C 1-6 -alkoxy-carbonyl group, a C 4-7 -cycloalkoxy-carbonyl or an aryloxycarbonyl group,
  • C 1-6 -alkoxy-carbonyl group which is terminally substituted in the alkyl moiety by a phenyl, heteroaryl, carboxy, C 1-3 -alkoxy-carbonyl, aminocarbonyl, C 1-3 -alkylamino-carbonyl or di-(C 1-3 -alkyl)-aminocarbonyl group,
  • an aminocarbonyl or methylaminocarbonyl group an ethylaminocarbonyl group optionally substituted in the 2 position of the ethyl group by a hydroxy or C 1-3 -alkoxy group or a di-(C 1-2 -alkyl)-aminocarbonyl group,
  • R 3 denotes a hydrogen atom, a C 1-6 -alkyl, C 3-7 -cycloalkyl, trifluoromethyl or heteroaryl group,
  • a phenyl or naphthyl group a phenyl or naphthyl group mono- or disubstituted by a fluorine, chlorine, bromine or iodine atom, by a trifluoromethyl, C 1-3 -alkyl or C 2-3 -alkoxy group, whilst in the event of disubstitution the substituents may be identical or different and wherein the abovementioned unsubstituted as well as the mono- and disubstituted phenyl and naphthyl groups may additionally be substituted
  • C 1-3 -alkylcarbonylamino N—(C 1-3 -alkyl)-C 1-3 -alkyl-carbonylamino, C 1-3 -alkylcarbonylamino-C 1-3 -alkyl, N—(C 1-3 -alkyl)-C 1-3 -alkylcarbonylamino-C 1-3 -alkyl, C 1-3 -alkyl-sulphonylamino, C 1-3 -alkylsulphonylamino-C 1-3 -alkyl, N—(C 1-3 -alkyl)-C 1-3 -alkylsulphonylamino-C 1-3 -alkyl or aryl-C 1-3 -alkylsulphonylamino group,
  • R 4 denotes a C 3-7 -cycloalkyl group
  • methylene group in the 4 position of a 6- or 7-membered cycloalkyl group may be substituted by an amino, C 1-3 -alkylamino or di-(C 1-3 -alkyl)-amino group or replaced by an —NH or —N(C 1-3 -alkyl) group,
  • R 6 a phenyl group substituted by the group R 6 , which may additionally be mono- or disubstituted by fluorine, chlorine, bromine or iodine atoms, by C 1-5 -alkyl, trifluoromethyl, hydroxy, C 1-3 -alkoxy, carboxy, C 1-3 -alkoxycarbonyl, amino, acetylamino, C 1-3 -alkyl-sulphonylamino, aminocarbonyl, C 1-3 -alkyl-aminocarbonyl, di-(C 1-3 -alkyl)-aminocarbonyl, aminosulphonyl, C 1-3 -alkyl-aminosulphonyl, di-(C 1-3 -alkyl)-aminosulphonyl, nitro or cyano groups, wherein the substituents may be identical or different and wherein
  • R 6 denotes a hydrogen, fluorine, chlorine, bromine or iodine atom
  • a C 1-3 -alkoxy group a C 1-3 -alkoxy-C 1-3 -alkoxy, phenyl-C 1-3 -alkoxy, amino-C 2-3 -alkoxy, C 1-3 -alkylamino-C 2-3 -alkoxy, di-(C 1-3 -alkyl)-amino-C 2-3 -alkoxy, phenyl-C 1-3 -alkylamino-C 2-3 -alkoxy, N—(C 1-3 -alkyl) -phenyl-C 1-3 -alkylamino-C 2-3 -alkoxy, C 5-7 -cycloalkyleneimino-C 2-3 -alkoxy or C 1-3 -alkylmercapto group,
  • methylene group in the 4 position of the 6- or 7-membered cycloalkyl moiety may be substituted by an amino, C 1-3 -alkylamino or di-(C 1-3 -alkyl)-amino group or replaced by an —NH or —N(C 1-3 -alkyl) group,
  • a methylene group linked to the imino group may be replaced by a carbonyl or sulphonyl group or
  • the cycloalkylene moiety may be fused to a phenyl ring or one or two hydrogen atoms may each be replaced by a C 1-3 -alkyl group and/or
  • the methylene group in the 4 position of a 6- or 7-membered cycloalkyleneimino group may be substituted by a carboxy, C 1-3 -alkoxycarbonyl, aminocarbonyl, C 1-3 -alkylaminocarbonyl, di-(C 1-3 -alkyl)-aminocarbonyl, phenyl-C 1-3 -alkylamino or N—(C 1-3 -alkyl)-phenyl-C 1-3 -alkylamino group or
  • R 7 denotes a C 3-7 -cycloalkyl group
  • a —(CH 2 ) 2 group may be replaced by a —CO—NH group
  • a —(CH 2 ) 3 group may be replaced by a —NH—CO—NH or —CO—NH—CO group or a —(CH 2 ) 4 group may be replaced by a —NH—CO—NH—CO group
  • a hydrogen atom bound to a nitrogen atom may be replaced by a C 1-3 -alkyl group
  • a hydroxy or C 1-3 -alkoxy group an amino, C 1-7 -alkylamino, di-(C 1-7 -alkyl) -amino, phenylamino, N-phenyl-C 1-3 -alkyl-amino, phenyl-C 1-3 -alkylamino, N—(C 1-3 -alkyl)-phenyl-C 1-3 -alkylamino or di-(phenyl-C 1-3 -alkyl)-amino group,
  • guanidino group wherein one or two hydrogen atoms may each be replaced by a C 1-3 -alkyl group
  • R 8 denotes a hydrogen atom or a C 1-3 -alkyl group
  • n denotes one of the numbers 0, 1, 2 or 3 and
  • R 9 denotes an amino, C 1-4 -alkylamino, di-(C 1-4 -alkyl)-amino, phenylamino, N—(C 1-4 -alkyl)-phenylamino, benzylamino,
  • R 10 denotes a hydrogen atom, a C 1-3 -alkyl group, a C 1-3 -alkylcarbonyl, arylcarbonyl, phenyl-C 2-3 -alkyl-carbonyl, C 1-3 -alkylsulphonyl, arylsulphonyl or phenyl-C 1-3 -alkylsulphonyl group,
  • n denotes one of the numbers 1, 2, 3 or 4,
  • ⁇ denotes the number 1 or, if m denotes one of the numbers 2, 3 or 4, o may also denote the number 0 and
  • R 11 denotes an amino, C 1-4 -alkylamino, di-(C 1-4 -alkyl)-amino, phenylamino, N—(C 1-4 -alkyl)-phenylamino, benzylamino, N—(C 1-4 -alkyl)-benzylamino, C 1-4 -alkoxy or C 1-3 -alkoxy-C 1-3 -alkoxy group, a di-(C 1-4 -alkyl)-amino-C 1-3 -alkylamino group optionally substituted in the 1 position by a C 1-3 -alkyl group or a 4- to 7-membered cycloalkyleneimino group, wherein the cycloalkylene moiety may be fused to a phenyl ring or in each case the methylene group in the 4 position of a 6- or 7-membered cycloalkyleneimino group may be replaced by an oxygen or sulph
  • the cycloalkylene moiety may be fused to a phenyl group or to an oxazolo, imidazolo, thiazolo, pyridino, pyrazino or pyrimidino group optionally substituted by a fluorine, chlorine, bromine or iodine atom, by a nitro, C 1-3 -alkyl, C 1-3 -alkoxy or amino group, and/or
  • one or two hydrogen atoms may each be replaced by a C 1-3 -alkyl, C 5-7 -cycloalkyl or phenyl group and/or
  • the methylene group in the 3 position of a 5-membered cycloalkyleneimino group may be substituted by a hydroxy, hydroxy-C 1-3 -alkyl, C 1-3 -alkoxy or C 1-3 -alkoxy-C 1-3 -alkyl group,
  • the methylene group in the 3 or 4 position of a 6- or 7-membered cycloalkyleneimino group may in each case be substituted by a hydroxy, hydroxy-C 1-3 -alkyl, C 1-3 -alkoxy, C 1-3 -alkoxy-C 1-3 -alkyl, carboxy, C 1-4 -alkoxycarbonyl, aminocarbonyl, C 1-3 -alkylaminocarbonyl, di-(C 1-3 -alkyl)-aminocarbonyl, phenyl-C 2-3 -alkylamino or N—(C 1-3 -alkyl)-phenyl-C 1-3 -alkyl-amino group or
  • sulphinyl, sulphonyl may be replaced by an oxygen or sulphur atom, by a sulphinyl, sulphonyl, —NH, —N(C 1-3 -alkyl-), —N(phenyl), —N(phenyl-C 1-3 -alkyl-), —N(C 1-3 -alkyl-carbonyl-), —N(C 1-4 -alkyl-hydroxy-carbonyl-), —N(C 1-4 -alkoxy-carbonyl-), —N(benzoyl-) or —N(phenyl-C 1-3 -alkyl-carbonyl-) group,
  • a methylene group linked to an imino-nitrogen atom of the cycloalkyleneimino group may be replaced by a carbonyl or sulphonyl group or in a 5- to 7-membered monocyclic cycloalkyleneimino group or a cycloalkyleneimino group fused to a phenyl group the two methylene groups linked to the imino-nitrogen atom may each be replaced by a carbonyl group,
  • R 6 denotes a C 1-4 -alkyl group which is substituted by a carboxy, C 1-3 -alkoxycarbonyl, aminocarbonyl, C 1-3 -alkylaminocarbonyl or di-(C 1-3 -alkyl)-aminocarbonyl group or by a 4- to 7-membered cycloalkyleneiminocarbonyl group,
  • R 12 denotes a hydrogen atom, a C 1-6 -alkyl or C 3-7 -cycloalkyl group or a C 1-3 -alkyl group terminally substituted by a phenyl, heteroaryl, trifluoromethyl, hydroxy, C 1-3 -alkoxy, aminocarbonyl, C 1-4 -alkylamino-carbonyl, di-(C 1-4 -alkyl)-amino-carbonyl, C 1-3 -alkyl-carbonyl, C 1-3 -alkyl-sulphonylamino, N—(C 1-3 -alkyl)-C 1-3 -alkyl-sulphonylamino, C 1-3 -alkyl-aminosulphonyl or di-(C 1-3 -alkyl) -aminosulphonyl group and
  • p denotes one of the numbers 0, 1, 2 or 3 and
  • R 13 assumes the meanings of the abovementioned group R 7 , or, if p denotes one of the numbers 1, 2 or 3, it may also denote a hydrogen atom,
  • R 14 denotes a hydrogen atom, a C 1-4 -alkyl group, a C 1-3 -alkylcarbonyl, arylcarbonyl, phenyl-C 1-3 -alkylcarbonyl, heteroarylcarbonyl, heteroaryl-C 1-3 -alkylcarbonyl, C 1-4 -alkylsulphonyl, arylsulphonyl, phenyl-C 1-3 -alkylsulphonyl, heteroarylsulphonyl or heteroaryl-C 1-3 -alkyl-sulphonyl group,
  • q denotes one of the numbers 1, 2, 3 or 4,
  • r denotes the number 1 or, if q is one of the numbers 2, 3 or 4, it may also denote the number 0 and
  • R 15 assumes the meanings of the abovementioned group R 7 .
  • R 16 denotes a hydrogen atom or a C 1-4 -alkyl group optionally terminally substituted by a cyano, trifluoromethyl-carbonylamino or N—(C 1-3 -alkyl)-trifluoromethyl-carbonyl-amino group and
  • R 17 denotes a C 1-3 -alkyl group
  • all the single-bonded or fused phenyl groups contained in the groups mentioned under R 6 may be mono- or disubstituted by fluorine, chlorine, bromine or iodine atoms, by C 1-5 -alkyl, trifluoromethyl, hydroxy, C 1-3 -alkoxy, carboxy, C 1-3 -alkoxycarbonyl, aminocarbonyl, C 1-4 -alkylamino-carbonyl, di-(C 1-4 -alkyl)-amino-carbonyl, aminosulphonyl, C 1-3 -alkyl-aminosulphonyl, di-(C 1-3 -alkyl)-aminosulphonyl, C 1-3 -alkyl-sulphonylamino, nitro or cyano groups, wherein the substituents may be identical or different, or two adjacent hydrogen atoms of the phenyl groups may be replaced by a methylenedioxy group, and
  • R 5 denotes a hydrogen atom or a C 1-3 -alkyl group
  • an aryl group is meant a phenyl or naphthyl group optionally mono- or disubstituted by a fluorine, chlorine, bromine or iodine atom, by a cyano, trifluoromethyl, nitro, carboxy, aminocarbonyl, C 1-3 -alkyl or C 1-3 -alkoxy group and
  • heteroaryl group a monocyclic 5- or 6-membered heteroaryl group optionally substituted by a C 1-3 -alkyl group in the carbon skeleton, wherein
  • the 6-membered heteroaryl group contains one, two or three nitrogen atoms and
  • the 5-membered heteroaryl group contains an imino group optionally substituted by a C 1-3 -alkyl or phenyl-C 1-3 -alkyl group, an oxygen or sulphur atom or
  • an imino group optionally substituted by a C 1-3 -alkyl or phenyl-C 1-3 -alkyl group or an oxygen or sulphur atom and additionally a nitrogen atom or
  • a phenyl ring may be fused to the abovementioned monocyclic heterocyclic groups via two adjacent carbon atoms and the bonding takes place via a nitrogen atom or via a carbon atom of the heterocyclic moiety or a fused phenyl ring,
  • the saturated alkyl and alkoxy moieties with more than 2 carbon atoms which are present in the groups defined hereinbefore also include the branched isomers thereof, such as for example the isopropyl, tert.butyl, isobutyl group, unless otherwise stated, and
  • the hydrogen atom of any carboxy group present or a hydrogen atom bound to a nitrogen atom may each be replaced by a group which can be cleaved in vivo.
  • a group which can be cleaved in vivo from an imino or amino group is meant, for example, a hydroxy group, an acyl group such as the benzoyl or pyridinoyl group or a C 1-16 -alkanoyl group such as the formyl, acetyl, propionyl, butanoyl, pentanoyl or hexanoyl group, an allyloxycarbonyl group, a C 1-16 -alkoxycarbonyl group such as the methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, butoxycarbonyl, tert.butoxycarbonyl, pentoxycarbonyl, hexyloxycarbonyl, octyloxycarbonyl, nonyloxycarbonyl, decyloxycarbonyl, undecyloxycarbonyl, dodecyloxycarbonyl or hexadecyl
  • R 6 denotes a C 1-8 -alkyl, C 5-7 -cycloalkyl, phenyl or phenyl-C 1-3 -alkyl group,
  • R f denotes a hydrogen atom, a C 1-3 -alkyl, C 5-7 -cycloalkyl or phenyl group and
  • R g denotes a hydrogen atom, a C 1-3 -alkyl or R e CO—O—(R f CR g )—O group wherein R e to R g are as hereinbefore defined,
  • amino group may be a phthalimido group
  • ester groups may also be used as a group which can be converted in vivo into a carboxy group
  • R 2 denotes a straight-chain or branched C 1-6 -alkoxy-carbonyl group, a C 4-7 -cycloalkoxycarbonyl or a aryloxycarbonyl group,
  • C 1-6 -alkoxy-carbonyl group which is terminally substituted in the alkyl moiety by a phenyl, heteroaryl, carboxy, C 1-3 -alkoxycarbonyl, aminocarbonyl, C 1-3 -alkylaminocarbonyl or di-(C 1-3 -alkyl)-aminocarbonyl group,
  • R 2 denotes an aminocarbonyl or methylaminocarbonyl group, an ethylaminocarbonyl group optionally substituted in the 2 position of the ethyl group by a hydroxy or C 1-3 -alkoxy group or a di-(C 1-2 -alkyl)-aminocarbonyl group,
  • R 4 denotes an R 7 -(C 1-4 -alkyl)-phenyl group, wherein
  • R 7 denotes an amino, C 1-7 -alkylamino, di-(C 1-7 -alkyl)-amino, phenylamino, N-phenyl-C 2-3 -alkyl-amino, phenyl-C 1-3 -alkylamino, N—(C 1-3 -alkyl)-phenyl-C 1-3 -alkylamino or di-(phenyl-C 1-3 -alkyl)-amino group,
  • Preferred compounds of general formula I are those wherein
  • R 1 and R 3 are as hereinbefore defined and X denotes an oxygen atom
  • R 2 denotes a carboxy group, a straight-chain or branched C 1-6 -alkoxy-carbonyl group, a C 5-7 -cycloalkoxycarbonyl or a phenoxycarbonyl group,
  • C 1-3 -alkoxy-carbonyl group which is terminally substituted in the alkyl moiety by a phenyl, heteroaryl, carboxy, C 1-3 -alkoxycarbonyl, aminocarbonyl, C 1-3 -alkylaminocarbonyl or di-(C 1-3 -alkyl)-aminocarbonyl group,
  • an aminocarbonyl or methylaminocarbonyl group an ethylaminocarbonyl group optionally substituted in the 2 position of the ethyl group by a hydroxy or C 1-3 -alkoxy group or a di-(C 1-2 -alkyl)-aminocarbonyl group,
  • R 4 denotes a C 3-7 -cycloalkyl group
  • methylene group in the 4 position of a 6- or 7-membered cycloalkyl group may be substituted by an amino, C 1-3 -alkylamino or di-(C 1-3 -alkyl)-amino group or replaced by an —NH or —N(C 1-3 -alkyl) group,
  • R 6 a phenyl group substituted by the group R 6 , which may additionally be mono- or disubstituted by fluorine, chlorine or bromine atoms, by C 1-3 -alkyl, trifluoromethyl, hydroxy, C 1-3 -alkoxy, carboxy, C 1-3 -alkoxycarbonyl, amino, acetylamino, aminocarbonyl, C 1-3 -alkyl-aminocarbonyl, di-(C 1-3 -alkyl)-aminocarbonyl, nitro or cyano groups, wherein the substituents may be identical or different and wherein
  • R 6 denotes a hydrogen, fluorine, chlorine, bromine or iodine atom
  • a C 1-3 -alkoxy group an amino-C 2-3 -alkoxy, C 1-3 -alkylamino-C 2-3 -alkoxy, di-(C 1-3 -alkyl)-amino-C 2-3 -alkoxy, phenyl-C 1-3 -alkylamino-C 2-3 -alkoxy, N—(C 1-3 -alkyl)-phenyl-C 1-3 -alkylamino-C 2-3 -alkoxy, pyrrolidino-C 2-3 -alkoxy, piperidino-C 2-3 -alkoxy or C 1-3 -alkylmercapto group,
  • a methylene group linked to the imino group may be replaced by a carbonyl or sulphonyl group or
  • one or two hydrogen atoms may each be replaced by a C 1-3 -alkyl group and/or
  • the methylene group in the 4 position of a 6- or 7-membered cycloalkyleneimino group may be substituted by a carboxy, C 1-3 -alkoxycarbonyl, aminocarbonyl, C 1-3 -alkylaminocarbonyl, di-(C 1-3 -alkyl)-aminocarbonyl, phenyl-C 1-3 -alkylamino or N—(C 1-3 -alkyl) -phenyl-C 1-3 -alkylamino group or
  • sulphinyl may be replaced by an oxygen or sulphur atom, by a sulphinyl, sulphonyl, —NH or —N(C 1-3 -alkyl) group,
  • R 7 denotes a C 5-7 -cycloalkyl group
  • methylene group in the 4 position of a 6- or 7-membered cycloalkyl group may be replaced by an —NH or —N(C 1-3 -alkyl) group or
  • a —(CH 2 ) 2 group may be replaced by a —CO—NH group
  • a —(CH 2 ) 3 group may be replaced by a —NH—CO—NH—
  • a —(CH 2 ) 4 group may be replaced by a —NH—CO—NH—CO group
  • a hydrogen atom bound to a nitrogen atom may be replaced by a C 1-3 -alkyl group
  • a ⁇ -hydroxy-C 2-3 -alkyl-amino N—(C 1-3 -alkyl)- ⁇ -hydroxy-C 2,3 -alkyl-amino, di-( ⁇ -hydroxy-C 2-3 -alkyl)-amino, di- ⁇ -(C 2-3 -alkoxy)-C 2-3 -alkyl)-amino or N-(dioxolan-2-yl)-C 1-3 -alkyl-amino group, a C 1-3 -alkylcarbonylamino-C 2-3 -alkyl-amino or C 1-3 -alkylcarbonylamino-C 2-3 -alkyl-N—(C 1-3 -alkyl)-amino group,
  • guanidino group wherein a hydrogen atom may be replaced by a C 1-3 -alkyl group
  • R 8 denotes a hydrogen atom or a C 1-3 -alkyl group
  • n denotes one of the numbers 0, 1, 2 or 3 and
  • R 9 denotes an amino, C 1-3 -alkylamino, di-(C 1-3 -alkyl)-amino, phenylamino, benzylamino or C 1-4 -alkoxy group, a 5- to 7-membered cycloalkyleneimino group, wherein the methylene group in position 4 of the piperidino group may be replaced by an oxygen or sulphur atom, by an —NH, —N(C 1-3 -alkyl), —N(phenyl), —N(C 1-3 -alkyl-carbonyl) or —N(benzoyl) group, or, if n denotes one of the numbers 1, 2 or 3, it may also denote a hydrogen atom,
  • R 10 denotes a hydrogen atom, a C 1-3 -alkyl group, a C 1-3 -alkylcarbonyl or C 1-3 -alkylsulphonyl group,
  • n denotes one of the numbers 1, 2 or 3,
  • ⁇ denotes the number 1 or, if m is one of the numbers 2 or 3, ⁇ may also denote the number 0 and
  • R 11 denotes an amino, C 1-3 -alkylamino, di-(C 1-3 -alkyl)-amino, C 1-4 -alkoxy or C 1-3 -alkoxy-C 1-3 -alkoxy group or a 5- to 7-membered cycloalkyleneimino group, wherein the methylene group in position 4 of the piperidino group may be replaced by an oxygen or sulphur atom, by an —NH, —N(C 1-3 -alkyl), —N(phenyl), —N(C 1-3 -alkyl-carbonyl) or —N(benzoyl) group,
  • cycloalkylene moiety may be fused to a phenyl group or
  • one or two hydrogen atoms may each be replaced by a C 1-3 -alkyl group and/or
  • the methylene group in position 3 of the pyrrolidino group may be substituted by a hydroxy or C 1-3 -alkoxy group
  • the methylene group in the 4 position of a 6- or 7-membered cycloalkyleneimino group may be substituted by a hydroxy, hydroxy-C 1-3 -alkyl, C 1-3 -alkoxy, carboxy, C 1-3 -alkoxycarbonyl, aminocarbonyl, C 1-3 -alkylaminocarbonyl, di-(C 1-3 -alkyl)-aminocarbonyl, phenyl-C 1-3 -alkylamino or N—(C 1-3 -alkyl)-phenyl-C 1-3 -alkylamino group or
  • sulphinyl, sulphonyl may be replaced by an oxygen or sulphur atom, by a sulphinyl, sulphonyl, —NH, —N(C 1-3 -alkyl), —N(phenyl), —N(phenyl-C 1-3 -alkyl), —N(C 1-3 -alkyl-carbonyl), —N(C 1-4 -alkoxy-carbonyl), —N(benzoyl) or —N(phenyl-C 1-3 -alkyl-carbonyl) group,
  • a methylene group linked to an imino-nitrogen atom of the cycloalkyleneimino group may be replaced by a carbonyl or sulphonyl group or in a 5- to 6-membered monocyclic cycloalkyleneimino group or a cycloalkyleneimino group fused to a phenyl group the two methylene groups linked to the imino-nitrogen atom may each be replaced by a carbonyl group,
  • R 6 denotes a C 1-4 -alkyl group which is terminally substituted by a carboxy, C 1-3 -alkoxycarbonyl, aminocarbonyl, C 1-3 -alkylaminocarbonyl or di-(C 1-3 -alkyl)-aminocarbonyl group or by a 4- to 7-membered cycloalkyleneiminocarbonyl group,
  • R 12 denotes a hydrogen atom, a C 1-3 -alkyl, C 5-7 -cycloalkyl, phenyl-C 1-3 -alkyl or heteroaryl-C 1-3 -alkyl group and
  • p denotes one of the numbers 0, 1, 2 or 3 and
  • R 13 assumes the meanings of the abovementioned group R 7 , or, if p denotes one of the numbers 1, 2 or 3, it may also denote a hydrogen atom,
  • R 14 denotes a hydrogen atom, a C 1-4 -alkyl group, a C 1-3 -alkylcarbonyl, phenylcarbonyl, phenyl-C 2-3 -alkylcarbonyl, heteroarylcarbonyl, heteroaryl-C 1-3 -alkylcarbonyl, C 1-4 -alkylsulphonyl, phenylsulphonyl, phenyl-C 1-3 -alkylsulphonyl-heteroarylsulphonyl or heteroaryl-C 1-3 -alkyl-sulphonyl group,
  • q denotes one of the numbers 1, 2, 3 or 4,
  • r denotes the number 1 or, if q is one of the numbers 2, 3 or 4, it may also denote the number 0 and
  • R 15 assumes the meanings of the abovementioned group R 7 .
  • R 16 denotes a hydrogen atom or a C 1-4 -alkyl group optionally terminally substituted by a cyano, trifluoromethyl-carbonylamino or N—(C 1-3 -alkyl)-trifluoromethyl-carbonyl-amino group and
  • R 17 denotes a C 1-3 -alkyl group
  • phenyl groups contained in the groups mentioned under R 6 may be mono- or disubstituted by fluorine, chlorine or bromine atoms, by C 1-3 -alkyl, trifluoromethyl, hydroxy, C 1-3 -alkoxy, carboxy, C 1-3 -alkoxycarbonyl, aminocarbonyl, C 1-3 -alkyl-aminocarbonyl, aminosulphonyl, C 1-3 -alkyl-aminosulphonyl, nitro or cyano groups, wherein the substituents may be identical or different, or two adjacent hydrogen atoms of the phenyl groups may be replaced by a methylenedioxy group, and
  • R 5 denotes a hydrogen atom or a C 1-3 -alkyl group
  • heteroaryl group as mentioned above is meant a pyridinyl, pyrazinyl, pyrimidinyl, pyridazinyl, pyrrolyl, furyl, thienyl, oxazolyl, thiazolyl, pyrazolyl, imidazolyl or triazolyl group optionally substituted in the carbon skeleton by a C 1-3 -alkyl group wherein a hydrogen atom bound to a nitrogen atom may be replaced by a C 1-3 -alkyl or phenyl-C 1-3 -alkyl group and wherein the 5-membered heteroaryl groups containing at least one imino group are bound via a carbon or nitrogen atom,
  • a hydrogen atom bound to a nitrogen atom in the abovementioned groups may be replaced by a group which can be cleaved in vivo, particularly by an acetyl or tert.butoxycarbonyl group,
  • the carboxy groups contained in the abovementioned groups may each be substituted by a group which can be cleaved in vivo and may occur, for example, in the form of the tert.butoxycarbonyl group,
  • saturated alkyl and alkoxy moieties contained in the abovementioned groups which contain more than 2 carbon atoms, may be straight-chain or branched, unless otherwise stated,
  • R 2 denotes a straight-chain or branched Cl -alkoxy-carbonyl group, a C 3-7 -cycloalkoxycarbonyl or a phenoxycarbonyl group,
  • C 1-3 -alkoxy-carbonyl group which is terminally substituted in the alkyl moiety by a phenyl-carboxy, C 1-3 -alkoxycarbonyl, aminocarbonyl, C 1-3 -alkylaminocarbonyl or di-(C 1-3 -alkyl)-aminocarbonyl group,
  • a second sub-group of preferred compounds of general formula I deserving special mention comprises those wherein
  • R 2 denotes an aminocarbonyl or methylaminocarbonyl group, an ethylaminocarbonyl group optionally substituted in the 2 position of the ethyl group by a hydroxy or C 1-3 -alkoxy group or a di-(C 1-2 -alkyl)-aminocarbonyl group,
  • a third sub-group of preferred compounds of general formula I deserving special mention comprises those wherein
  • R 4 denotes an R 7 -(n-C 1-4 -alkyl)-phenyl group, wherein
  • R 7 denotes an amino, C 1-6 -alkylamino, di-(C 1-6 -alkyl)-amino, phenylamino, N-phenyl-C 2-3 -alkyl-amino, phenyl-C 1-3 -alkylamino, N—(C 1-3 -alkyl)-phenyl-C 1-3 -alkylamino or di-(phenyl-C 1-3 -alkyl)-amino group,
  • X denotes an oxygen atom
  • R 1 denotes a hydrogen atom
  • R 2 denotes a carboxy group, a straight-chain or branched C 1-4 -alkoxycarbonyl group or a phenoxycarbonyl group,
  • C 1-3 -alkoxy-carbonyl group which is terminally substituted in the alkyl moiety by a phenyl, carboxy, C 1-3 -alkoxycarbonyl, aminocarbonyl, C 1-3 -alkylaminocarbonyl or di-(C 1-3 -alkyl)-aminocarbonyl group,
  • an aminocarbonyl or methylaminocarbonyl group an ethylaminocarbonyl group optionally substituted in the 2 position of the ethyl group by a hydroxy or C 1-3 -alkoxy group or a di-(C 1-2 -alkyl)-aminocarbonyl group,
  • R 3 denotes a C 1-4 -alkyl group or a phenyl group which may be substituted by a fluorine, chlorine or bromine atom, by a trifluoromethyl, C 1-3 -alkyl, hydroxy or C 1-3 -alkoxy group,
  • R 4 denotes a C 5-6 -cycloalkyl group
  • methylene group in position 4 of the cyclohexyl group may be substituted by an amino, C 1-3 -alkylamino or di-(C 1-3 -alkyl)-amino group or replaced by an —NH or —N(C 1-3 -alkyl) group,
  • a phenyl group a phenyl group disubstituted by C 1-3 -alkyl, C 1-3 -alkoxy or nitro groups, wherein the substituents may be identical or different, or
  • R 6 a phenyl group substituted by the group R 6 , which may additionally be substituted by a fluorine, chlorine or bromine atom or by an amino or nitro group, wherein R 6 denotes a fluorine, chlorine or bromine atom,
  • the methylene group in position 4 of the piperidino group may be replaced by an oxygen or sulphur atom, by an —NH or —N(C 1-3 -alkyl) group,
  • R 7 denotes a C 5-7 -cycloalkyl group
  • a —(CH 2 ) 2 group may be replaced by a —CO—NH group
  • a —(CH 2 ) 3 group may be replaced by an —NH—CO—NH—
  • a —(CH 2 ) 4 group may be replaced by an —NH—CO—NH—CO group
  • a hydrogen atom bound to a nitrogen atom may be replaced by a C 1-3 -alkyl group
  • a phenyl or pyridinyl group or a pyrrolyl pyrazolyl, imidazolyl or triazolyl group bound via a carbon or nitrogen atom
  • the abovementioned heteroaromatic groups in the carbon skeleton may be substituted by a C 1-3 -alkyl group or a hydrogen atom bound to a nitrogen atom may be replaced by a C 1-3 -alkyl group
  • guanidino group wherein a hydrogen atom may be replaced by a C 1-3 -alkyl group
  • R 8 denotes a hydrogen atom or a C 1-3 -alkyl group
  • n denotes one of the numbers 0, 1, 2 or 3 and
  • R 9 denotes an amino, C 1-3 -alkylamino, di-(C 1-3 -alkyl)-amino or C 1-4 -alkoxy group, a 5- or 6-membered cycloalkyleneimino group, wherein the methylene group in position 4 of the piperidino group may be replaced by an —NH, —N(C 1-3 -alkyl) or —N(C 1-3 -alkyl-carbonyl) group, or, if n denotes one of the numbers 1, 2 or 3, R, may also denote a hydrogen atom,
  • R 10 denotes a hydrogen atom or a C 1-3 -alkyl group
  • n denotes one of the numbers 1, 2 or 3,
  • ⁇ denotes the number 1 or, if m is one of the numbers 2 or 3, ⁇ may also denote the number 0 and R 11 denotes an amino, C 1-3 -alkylamino, di-(C 1-3 -alkyl)-amino, C 1-4 -alkoxy or methoxy-C 1-3 -alkoxy group or a 5- or 6-membered cycloalkyleneimino group, wherein the methylene group in position 4 of the piperidino group may be replaced by an —NH, —N(C 1-3 -alkyl) or —N(C 1-3 -alkyl-carbonyl) group,
  • the methylene group in position 3 of the pyrrolidino group may be substituted by a hydroxy group
  • the methylene group in position 4 of the piperidino group may be substituted by a hydroxy, hydroxy-C 1-3 -alkyl or C 1-3 -alkoxy group or
  • sulphinyl, sulphonyl may be replaced by an oxygen or sulphur atom, by a sulphinyl, sulphonyl, —NH, —N(C 1-3 -alkyl), —N(C 1-3 -alkyl-carbonyl), —N(benzoyl) or —N(phenyl-C 1-3 -alkyl-carbonyl) group,
  • a methylene group linked to an imino-nitrogen atom of the pyrrolidino, piperidino or piperazino group may be replaced by a carbonyl group
  • R 6 denotes a straight-chain C 1-3 -alkyl group which is terminally substituted by a carboxy or C 1-3 -alkoxy-carbonyl group
  • R 12 denotes a hydrogen atom, a C 1-3 -alkyl or phenyl-C 1-3 -alkyl group
  • p denotes one of the numbers 0, 1 or 2 and
  • R 13 denotes an amino, C 1-4 -alkylamino, di-(C 1-4 -alkyl)-amino, benzylamino, N—(C 1-3 -alkyl) -benzylamino, C 1-3 -alkoxy-C 1-3 -alkylamino, N—(C 1-3 -alkyl)-C 1-3 -alkoxy-C 1-3 -alkylamino, di-(2-methoxy-ethyl)-amino, di-( ⁇ -hydroxy-C 1-3 -alkyl)-amino or aminocarbonyl-methyl-N-(methyl)-amino group,
  • R 14 denotes a hydrogen atom, a C 1-4 -alkyl, C 2-3 -alkyl-carbonyl, phenylcarbonyl, phenyl-C 1-3 -alkylcarbonyl, furyl-carbonyl, pyridinyl-carbonyl, furyl-C 1-3 -alkylcarbonyl, pyridinyl-C 1-3 -alkylcarbonyl, C 1-4 -alkylsulphonyl, phenylsulphonyl or phenyl-C 1-3 -alkylsulphonyl group,
  • q denotes one of the numbers 1, 2 or 3,
  • r denotes the number 1 or, if q is one of the numbers 2 or 3, it may also denote the number 0 and
  • R 15 denotes an amino, C 1-4 -alkylamino, di-(C 1-4 -alkyl)-amino, phenylamino, N—(C 1-4 -alkyl)-phenylamino, benzylamino or N—(C 1-4 -alkyl) -benzylamino group,
  • R 16 denotes a hydrogen atom or a C 1-3 -alkyl group optionally terminally substituted by a cyano, trifluoromethyl-carbonylamino or N—(C 1-3 -alkyl)-trifluoromethyl-carbonyl-amino group and
  • R 17 denotes a C 1-3 -alkyl group
  • R 5 denotes a hydrogen atom
  • carboxy groups contained in the abovementioned groups may also be present in the form of the tert.butoxycarbonyl precursor group and
  • saturated alkyl and alkoxy moieties contained in the abovementioned groups which contain more than 2 carbon atoms, may be straight-chain or branched, unless otherwise stated,
  • R 2 denotes a straight-chain or branched C 1-4 -alkoxycarbonyl group or a phenoxycarbonyl group
  • C 1-3 -alkoxycarbonyl group which is terminally substituted in the alkyl moiety by a phenyl-carboxy, C 1-3 -alkoxycarbonyl, aminocarbonyl, C 1-3 -alkylaminocarbonyl or di-(C 1-3 -alkyl)-aminocarbonyl group, or
  • R 4 denotes an R 7 -(n-C 1-3 -alkyl)-phenyl group, wherein
  • R 7 denotes an amino, C 1-6 -alkylamino, di-(C 1-4 -alkyl)-amino, ⁇ -hydroxy-C 2-3 -alkyl-amino,
  • a second subgroup of particularly preferred compounds of general formula I deserving special mention comprises those wherein
  • R 2 denotes an aminocarbonyl or methylaminocarbonyl group, an ethylaminocarbonyl group optionally substituted in the 2 position of the ethyl group by a hydroxy or C 1-3 -alkoxy group or a di-(C 1-2 -alkyl)-aminocarbonyl group and
  • R 4 denotes a R 7 -(n-C 1-3 -alkyl)-phenyl group, wherein
  • R 7 denotes an amino, C 1-6 -alkylamino, di-(C 1-4 -alkyl)-amino, ⁇ -hydroxy-C 2-3 -alkyl-amino, N—(C 1-3 -alkyl)- ⁇ -hydroxy-C 2-3 -alkyl-amino, di-( ⁇ -hydroxy-C 2-3 -alkyl)-amino or di-( ⁇ -(C 1-3 -alkoxy)-C 2-3 -alkyl)-amino group,
  • X denotes an oxygen atom
  • R 1 and R 5 each denote a hydrogen atom
  • R 2 denotes a methoxycarbonyl, ethoxycarbonyl or aminocarbonyl group
  • R 3 denotes a phenyl group
  • R 4 denotes a phenyl group monosubstituted by the group R 6 , wherein
  • R 6 denotes an N-methyl-imidazol-2-yl group
  • R 12 denotes a C 1-3 -alkyl group
  • p denotes one of the numbers 1 or 2 and
  • R 13 denotes a di-(C 1-3 -alkyl)-amino group
  • R 14 denotes a C 1-3 -alkyl-carbonyl or C 1-3 -alkylsulphonyl group
  • q denotes one of the numbers 1, 2 or 3,
  • r denotes the number 1 or, if q is one of the numbers 2 or 3, r may also denote the number 0 and
  • R 15 denotes a di-(C 1-3 -alkyl)-amino group
  • saturated alkyl moieties contained in the abovementioned groups which contain more than 2 carbon atoms may be straight-chain or branched, unless otherwise stated,
  • R 2 denotes a methoxycarbonyl or ethoxycarbonyl group
  • R 4 denotes a di-(C 1-3 -alkyl)-amino-C 1-3 -alkylphenyl group or
  • Another subgroup of compounds of general formula I comprises those wherein
  • X denotes an oxygen or sulphur atom
  • R 1 denotes a hydrogen atom or a prodrug group such as a C 1-4 -alkoxycarbonyl or C 2-4 -alkanoyl group,
  • R 2 denotes a carboxy group, a straight-chain or branched C 1-6 -alkoxycarbonyl group, a C 5-7 -cycloalkoxycarbonyl or phenyl-C 1-3 -alkoxycarbonyl group, an aminocarbonyl or C 1-2 -alkylaminocarbonyl group or, if R 4 does not denote an aminosulphonyl-phenyl or N—(C 1-5 -alkyl)-C 1-3 -alkylaminocarbonyl-phenyl group, a di-(C 1-2 -alkyl)-aminocarbonyl group,
  • R 3 denotes a hydrogen atom, a C 1-6 -alkyl, C 3-7 -cycloalkyl, trifluoromethyl or heteroaryl group,
  • a phenyl or naphthyl group a phenyl or naphthyl group mono- or disubstituted by a fluorine, chlorine, bromine or iodine atom, by a trifluoromethyl, C 1-3 -alkyl or C 1-3 -alkoxy group, whilst in the event of disubstitution the substituents may be identical or different and wherein the abovementioned unsubstituted as well as the mono- and disubstituted phenyl and naphthyl groups may additionally be substituted
  • C 1-3 -alkylcarbonylamino N—(C 1-3 -alkyl)-C 1-3 -alkylcarbonylamino, C 1-3 -alkylcarbonylamino-C 1-3 -alkyl, N—(C 1-3 -alkyl)-C 1-3 -alkylcarbonylamino-C 1-3 -alkyl, C 1-3 -alkylsulphonylamino, C 1-3 -alkylsulphonylamino-C 1-3 -alkyl, N—(C 1-3 -alkyl)-C 1-3 -alkylsulphonylamino-C 1-3 -alkyl or aryl-C 1-3 -alkylsulphonylamino group,
  • R 4 denotes a C 3-7 -cycloalkyl group
  • methylene group in the 4 position of a 6- or 7-membered cycloalkyl group may be substituted by an amino, C 1-3 -alkylamino or di-(C 1-3 -alkyl)-amino group or replaced by an —NH or —N(C 1-3 -alkyl) group,
  • R 6 a phenyl group substituted by the group R 6 , which may additionally be substituted by a fluorine, chlorine, bromine or iodine atom, by a C 1-5 alkyl, trifluoromethyl, C 1-3 -alkoxy, carboxy, C 1-3 -alkoxycarbonyl, aminosulphonyl, nitro or cyano group, wherein
  • R 6 denotes a hydrogen, fluorine, chlorine, bromine or iodine atom
  • a C 1-3 -alkoxy group optionally unsubstituted by 1 to 3 fluorine atoms, a C 1-3 -alkoxy-C 1-3 -alkoxy, phenyl-C 1-3 -alkoxy, amino-C 2-3 -alkoxy, C 1-3 -alkylamino-C 2-3 -alkoxy, di-(C 1-3 -alkyl)-amino-C 2-3 -alkoxy, phenyl-C 1-3 -alkylamino-C 2-3 -alkoxy, N—(C 1-3 -alkyl)-phenyl-C 1-3 -alkylamino-C 2-3 -alkoxy, C 5-7 -cycloalkyleneimino-C 2-3 -alkoxy or C 1-3 -alkylmercapto group,
  • a methylene group linked to the imino group may be replaced by a carbonyl or sulphonyl group or
  • cycloalkylene moiety may be fused to a phenyl ring or
  • one or two hydrogen atoms may each be replaced by a C 1-3 -alkyl group and/or
  • the methylene group in the 4 position of a 6- or 7-membered cycloalkyleneimino group may be substituted by a carboxy, C 1-3 -alkoxycarbonyl, aminocarbonyl, C 1-3 -alkylaminocarbonyl, di-(C 1-3 -alkyl) -aminocarbonyl, phenyl-C 1-3 -alkylamino or N—(C 1-3 -alkyl)-phenyl-C 1-3 -alkylamino group or
  • sulphinyl may be replaced by an oxygen or sulphur atom, by a sulphinyl, sulphonyl, —NH, —N(C 1-3 -alkyl), —N(phenyl), —N(C 1-3 -alkyl-carbonyl) or —N(benzoyl) group,
  • a methylene group linked to the imino group may be replaced by a carbonyl or sulphonyl group or
  • the cycloalkylene moiety may be fused to a phenyl group or to an oxazolo, imidazolo, thiazolo, pyridino, pyrazino or pyrimidino group optionally substituted by a fluorine, chlorine, bromine or iodine atom, by a nitro, C 1-3 -alkyl, C 1-3 -alkoxy or amino group or
  • one or two hydrogen atoms may each be replaced by a C 1-3 -alkyl, C 5-7 -cycloalkyl or phenyl group and/or
  • the methylene group in the 4 position of a 6- or 7-membered cycloalkyleneimino group may be substituted by a hydroxy, carboxy, C 1-4 -alkoxycarbonyl, aminocarbonyl, C 1-3 -alkylaminocarbonyl, di-(C 1-3 -alkyl) -aminocarbonyl, phenyl-C 1-3 -alkylamino or N—(C 1-3 -alkyl)-phenyl-C 1-3 -alkylamino group or
  • R 8 denotes a hydrogen atom or a C 1-3 -alkyl group
  • n denotes one of the numbers 0, 1, 2 or 3 and
  • R 9 denotes an amino, C 1-4 -alkylamino, phenylamino, N—(C 1-4 -alkyl)-phenylamino, benzylamino, N—(C 1-4 -alkyl)-benzylamino or di-(C 1-4 -alkyl)-amino group, a 4- to 7-membered cycloalkyleneimino group, whilst in each case the methylene group in the 4 position of a 6- or 7-membered cycloalkyleneimino group may be replaced by an oxygen or sulphur atom, by a sulphinyl,
  • sulphonyl —NH, —N(C 1-3 -alkyl), —N(phenyl), —N(C 1-3 -alkyl-carbonyl) or —N(benzoyl) group, or, if n denotes one of the numbers 1, 2 or 3, it may also denote a hydrogen atom,
  • R 10 denotes a hydrogen atom, a C 1-3 -alkyl group, a C 1-3 -alkylcarbonyl, arylcarbonyl, phenyl-C 1-3 -alkylcarbonyl, C 1-3 -alkylsulphonyl, arylsulphonyl or phenyl-C 1-3 -alkylsulphonyl group,
  • n denotes one of the numbers 1, 2, 3 or 4,
  • ⁇ denotes one of the numbers 0 or 1 and
  • R 11 denotes an amino, C 1-4 -alkylamino, phenylamino, N—(C 1-4 -alkyl)-phenylamino, benzylamino, N—(C 1-4 -alkyl)-benzylamino or di-(C 1-4 -alkyl)-amino group, a 4- to 7-membered cycloalkyleneimino group, wherein the cycloalkylene moiety may be fused to a phenyl ring or in each case the methylene group in the 4 position of a 6- or 7-membered cycloalkyleneimino group may be replaced by an oxygen or sulphur atom, by a sulphinyl, sulphonyl, —NH, —N(C 1-3 -alkyl), —N(phenyl), —N(C 1-3 -alkyl-carbonyl) or —N(benzoyl) group, a C
  • phenyl groups contained in the groups mentioned under R 6 may be mono- or disubstituted by fluorine, chlorine, bromine or iodine atoms, by C 1-5 -alkyl, trifluoromethyl, C 1-3 -alkoxy, carboxy, C 1-3 -alkoxycarbonyl, aminosulphonyl, nitro or cyano groups, wherein the substituents may be identical or different, or two adjacent hydrogen atoms of the phenyl groups may be replaced by a methylenedioxy group, and
  • R 5 denotes a hydrogen atom or a C 1-3 -alkyl group
  • aryl group a phenyl or naphthyl group optionally mono- or disubstituted by a fluorine, chlorine, bromine or iodine atom, by a trifluoromethyl, C 1-3 -alkyl or C 1-3 -alkoxy group and
  • heteroaryl group a monocyclic 5- or 6-membered heteroaryl group optionally substituted by a C 1-3 -alkyl group, wherein the 6-membered heteroaryl group contains one, two or three nitrogen atoms and the 5-membered heteroaryl group contains an imino group optionally substituted by a C 1-3 -alkyl group, an oxygen or sulphur atom or an imino group optionally substituted by a C 1-3 -alkyl group and an oxygen or sulphur atom or one or two nitrogen atoms, and moreover a phenyl ring may be fused to the abovementioned monocyclic heterocyclic groups via two adjacent carbon atoms,
  • the saturated alkyl and alkoxy moieties present in the groups defined above which contain more than 2 carbon atoms also include the branched isomers thereof such as, for example, the isopropyl, tert.butyl or isobutyl group, unless otherwise stated, and
  • any carboxy, amino or imino group present may be substituted by a group which can be cleaved in viva,
  • TBTU O-benzotriazol-1-yl-N,N,N′,N′-tetramethyluronium-tetrafluoroborate
  • the aqueous phase is three times extracted with ethyl acetate and the combined organic phases are dried over sodium sulphate. After evaporation of the solvent the residue is purified over a silica gel column with methylene chloride/methanol (9:1) as eluant.
  • starting material VI 1-acetyl-3-(1-ethoxy-methylene)-6-methoxycarbonyl-2-indolinone (starting material VI) are dissoled in 150 ml of methanol and 86.4 ml of 1N sodium hydroxide solution are added. The mixture is refluxed for 8.5 hrs. After that time 86.4 ml of 1N hydrochloric acid are added. The residue is filtered off and dried at 90° C.
  • Tautomers, stereoisomers or physiologically acceptable salts of these compounds are also contemplated within the scope of the present invention, and may be obtained using the methods described in WO 01/27081, the content of which is herein incorporated by reference.
  • a particularly preferred compound is the monoethanesulphonate salt of 3-Z-[1-(4-(N-((4-methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone, disclosed for example in WO 04/13099, the content of which is incorporated herein by reference.
  • WO 04/13099 describes metabolites and prodrugs of the compound 3-Z-[1-(4-(N-((4-methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone-monoethanesulphonate.
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