EA200701302A1 - 4-(n-фениламино)хиназолины/-хинолины в качестве ингибиторов тирозинкиназы - Google Patents
4-(n-фениламино)хиназолины/-хинолины в качестве ингибиторов тирозинкиназыInfo
- Publication number
- EA200701302A1 EA200701302A1 EA200701302A EA200701302A EA200701302A1 EA 200701302 A1 EA200701302 A1 EA 200701302A1 EA 200701302 A EA200701302 A EA 200701302A EA 200701302 A EA200701302 A EA 200701302A EA 200701302 A1 EA200701302 A1 EA 200701302A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- diseases
- primarily
- compounds
- thyrosinkinase
- phylenamino
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
В заявке описаны бициклические гетероциклы общей формулы (I)в которой R, R, R, Rи Х имеют указанные в п.1 формулы изобретения значения, их таутомеры, их стереоизомеры, их смеси и их соли, прежде всего их физиологически совместимые соли с неорганическими или органическими кислотами, при этом такие соединения обладают ценными фармакологическими свойствами, прежде всего ингибирующим действием на опосредуемую тирозинкиназами трансдукцию сигналов, а также описано применение этих соединений для лечения заболеваний различного рода, прежде всего опухолевых заболеваний, а также доброкачественной гиперплазии предстательной железы, заболеваний легких и дыхательных путей, и их получение.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10214412A DE10214412A1 (de) | 2002-03-30 | 2002-03-30 | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
DE2002131711 DE10231711A1 (de) | 2002-07-13 | 2002-07-13 | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
Publications (1)
Publication Number | Publication Date |
---|---|
EA200701302A1 true EA200701302A1 (ru) | 2007-12-28 |
Family
ID=28676040
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200401191A EA009300B1 (ru) | 2002-03-30 | 2003-03-25 | 4-(n-фениламино)хиназолины/-хинолины в качестве ингибиторов тирозинкиназы |
EA200701302A EA200701302A1 (ru) | 2002-03-30 | 2003-03-25 | 4-(n-фениламино)хиназолины/-хинолины в качестве ингибиторов тирозинкиназы |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200401191A EA009300B1 (ru) | 2002-03-30 | 2003-03-25 | 4-(n-фениламино)хиназолины/-хинолины в качестве ингибиторов тирозинкиназы |
Country Status (24)
Country | Link |
---|---|
EP (1) | EP1492536B1 (ru) |
JP (1) | JP4776882B2 (ru) |
KR (1) | KR101064530B1 (ru) |
CN (1) | CN1642552B (ru) |
AR (1) | AR039187A1 (ru) |
AT (1) | ATE557008T1 (ru) |
AU (1) | AU2003226705B2 (ru) |
BR (1) | BR0308902A (ru) |
CA (1) | CA2476008C (ru) |
EA (2) | EA009300B1 (ru) |
HK (1) | HK1079095A1 (ru) |
HR (1) | HRP20040898A2 (ru) |
IL (1) | IL164167A0 (ru) |
ME (1) | MEP47208A (ru) |
MX (1) | MXPA04009536A (ru) |
MY (1) | MY127771A (ru) |
NO (1) | NO329271B1 (ru) |
NZ (1) | NZ536114A (ru) |
PE (1) | PE20040169A1 (ru) |
PL (1) | PL371188A1 (ru) |
RS (1) | RS85404A (ru) |
TW (2) | TW201024269A (ru) |
UY (1) | UY27737A1 (ru) |
WO (1) | WO2003082290A1 (ru) |
Families Citing this family (66)
Publication number | Priority date | Publication date | Assignee | Title |
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UA71976C2 (en) | 1999-06-21 | 2005-01-17 | Boehringer Ingelheim Pharma | Bicyclic heterocycles and a medicament based thereon |
US7019012B2 (en) | 2000-12-20 | 2006-03-28 | Boehringer Ingelheim International Pharma Gmbh & Co. Kg | Quinazoline derivatives and pharmaceutical compositions containing them |
US6924285B2 (en) | 2002-03-30 | 2005-08-02 | Boehringer Ingelheim Pharma Gmbh & Co. | Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them |
ES2400339T3 (es) * | 2002-07-15 | 2013-04-09 | Symphony Evolution, Inc. | Compuestos, composiciones farmacéuticas de los mismos y su uso en el tratamiento del cáncer |
BRPI0410720A (pt) * | 2003-05-27 | 2006-06-20 | Pfizer Prod Inc | quinazolinas e pirido[3,4-d]pirimidinas como inibidores do receptor de tirosina cinase |
US8309562B2 (en) | 2003-07-03 | 2012-11-13 | Myrexis, Inc. | Compounds and therapeutical use thereof |
DE10334226A1 (de) * | 2003-07-28 | 2005-02-17 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verwendung von Tyrosinkinase-Inhibitoren zur Behandlung inflammatorischer Prozesse |
GB0317665D0 (en) | 2003-07-29 | 2003-09-03 | Astrazeneca Ab | Qinazoline derivatives |
UY28441A1 (es) * | 2003-07-29 | 2005-02-28 | Astrazeneca Ab | Derivados de quinazolina |
WO2005026151A1 (en) * | 2003-09-16 | 2005-03-24 | Astrazeneca Ab | Quinazoline derivatives as tyrosine kinase inhibitors |
ATE395346T1 (de) * | 2003-09-16 | 2008-05-15 | Astrazeneca Ab | Chinazolinderivate als tyrosinkinaseinhibitoren |
US20070037837A1 (en) * | 2003-09-19 | 2007-02-15 | Hennequin Laurent Francois A | Quinazoline derivatives |
SI1667992T1 (sl) * | 2003-09-19 | 2007-06-30 | Astrazeneca Ab | Kinazolinski derivati |
GB0322409D0 (en) * | 2003-09-25 | 2003-10-29 | Astrazeneca Ab | Quinazoline derivatives |
DE10345875A1 (de) * | 2003-09-30 | 2005-04-21 | Boehringer Ingelheim Pharma | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Vewendung und Verfahren zu ihrer Herstellung |
US7456189B2 (en) | 2003-09-30 | 2008-11-25 | Boehringer Ingelheim International Gmbh | Bicyclic heterocycles, medicaments containing these compounds, their use and processes for their preparation |
DE10350717A1 (de) * | 2003-10-30 | 2005-06-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verwendung von Tyrosinkinase-Inhibitoren zur Behandlung inflammatorischer Prozesse |
GB0326459D0 (en) | 2003-11-13 | 2003-12-17 | Astrazeneca Ab | Quinazoline derivatives |
EA013904B1 (ru) | 2003-12-18 | 2010-08-30 | Янссен Фармацевтика Н.В. | Пиридо- и пиримидопиримидиновые производные в качестве антипролиферативных агентов |
AU2004298784B2 (en) | 2003-12-18 | 2011-06-09 | Janssen Pharmaceutica N.V | 3-cyano-quinoline derivatives with antiproliferative activity |
US20060035893A1 (en) | 2004-08-07 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders |
NI200700147A (es) | 2004-12-08 | 2019-05-10 | Janssen Pharmaceutica Nv | Derivados de quinazolina inhibidores de cinasas dirigidos a multip |
ATE501148T1 (de) | 2004-12-14 | 2011-03-15 | Astrazeneca Ab | Pyrazolopyrimidinverbindungen als antitumormittel |
PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
US8258145B2 (en) | 2005-01-03 | 2012-09-04 | Myrexis, Inc. | Method of treating brain cancer |
CA2592900A1 (en) | 2005-01-03 | 2006-07-13 | Myriad Genetics Inc. | Nitrogen containing bicyclic compounds and therapeutical use thereof |
EP1845992A1 (de) * | 2005-02-04 | 2007-10-24 | Boehringer Ingelheim International GmbH | Verwendung von tyrosinkinase-inhibitoren zur behandlung der chronischen rhinosinusitis |
WO2006081741A1 (fr) * | 2005-02-05 | 2006-08-10 | Piaoyang Sun | Dérivés de quinazoline ou leurs sels de qualité pharmaceutique, synthèse et applications médicales desdites substances |
JP5054544B2 (ja) * | 2005-02-26 | 2012-10-24 | アストラゼネカ アクチボラグ | チロシンキナーゼ阻害剤としてのキナゾリン誘導体 |
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JP2009529511A (ja) * | 2006-03-09 | 2009-08-20 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 二環式複素環化合物、これらの化合物を含む医薬組成物、その使用方法及び製造方法 |
ES2569428T3 (es) | 2006-07-13 | 2016-05-10 | Janssen Pharmaceutica Nv | Derivados de quinazolina como MTKI |
US20080221132A1 (en) * | 2006-09-11 | 2008-09-11 | Xiong Cai | Multi-Functional Small Molecules as Anti-Proliferative Agents |
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PT2068880E (pt) | 2006-09-18 | 2012-07-12 | Boehringer Ingelheim Int | Método para tratamento do cancro apresentando mutações no egfr |
EP1921070A1 (de) * | 2006-11-10 | 2008-05-14 | Boehringer Ingelheim Pharma GmbH & Co. KG | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstelllung |
WO2008095847A1 (de) | 2007-02-06 | 2008-08-14 | Boehringer Ingelheim International Gmbh | Bicyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
EP1956010A1 (de) * | 2007-02-06 | 2008-08-13 | Boehringer Ingelheim Pharma GmbH & Co. KG | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel,deren Verwendung und Verfahren zu ihrer Herstellung |
TWI377944B (en) | 2007-06-05 | 2012-12-01 | Hanmi Holdings Co Ltd | Novel amide derivative for inhibiting the growth of cancer cells |
AU2008281849B2 (en) | 2007-07-27 | 2013-11-28 | Janssen Pharmaceutica Nv | Pyrrolopyrimidines |
EP2245026B1 (de) * | 2008-02-07 | 2012-08-01 | Boehringer Ingelheim International GmbH | Spirocyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
JP5739802B2 (ja) * | 2008-05-13 | 2015-06-24 | アストラゼネカ アクチボラグ | 4−(3−クロロ−2−フルオロアニリノ)−7−メトキシ−6−{[1−(n−メチルカルバモイルメチル)ピペリジン−4−イル]オキシ}キナゾリンのフマル酸塩 |
US8372855B2 (en) | 2008-08-08 | 2013-02-12 | Boehringer Ingelheim International Gmbh | Cyclohexyloxy-substituted heterocyclics, medicines containing these compounds and method for the production thereof |
EP2313397B1 (de) * | 2008-08-08 | 2016-04-20 | Boehringer Ingelheim International GmbH | Cyclohexyloxy-substituierte heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
EP2313377B1 (de) * | 2008-08-08 | 2016-01-06 | Boehringer Ingelheim International Gmbh | Verfahren zur stereoselektiven synthese bicyclischer heterocyclen |
CN101659658B (zh) * | 2008-08-29 | 2014-04-02 | 北大方正集团有限公司 | 氰基取代的喹啉衍生物 |
CN101659657B (zh) * | 2008-08-29 | 2014-05-14 | 北大方正集团有限公司 | 氰基取代的喹啉衍生物及其制备方法和用途 |
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CN102452988B (zh) * | 2010-10-27 | 2016-01-27 | 中国科学院化学研究所 | 一种喹唑啉衍生物及其制备方法 |
JP2014504619A (ja) | 2011-02-01 | 2014-02-24 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 9−[4−(3−クロロ−2−フルオロ−フェニルアミノ)−7−メトキシ−キナゾリン−6−イルオキシ]−1,4−ジアザ−スピロ[5.5]ウンデカン−5−オンジマレアート、その医薬としての使用及びその製造方法 |
KR101317809B1 (ko) | 2011-06-07 | 2013-10-16 | 한미약품 주식회사 | 암세포의 성장을 억제하는 아마이드 유도체 및 비금속염 활택제를 포함하는 약학 조성물 |
KR20140128318A (ko) | 2012-02-09 | 2014-11-05 | 베링거 인겔하임 인터내셔날 게엠베하 | 1,4-보호된 9-하이드록시-5-옥소-1,4-디아자-스피로 [5.5] 운데칸의 입체선택적 합성 방법 |
US9193718B2 (en) | 2012-03-26 | 2015-11-24 | Fujian Institute Of Research On The Structure Of Matter, Chinese Academy Of Sciences | Quinazoline derivative and application thereof |
JP2015524400A (ja) | 2012-07-19 | 2015-08-24 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 9−[4−(3−クロロ−2−フルオロ−フェニルアミノ)−7−メトキシ−キナゾリン−6−イルオキシ]−1,4−ジアザ−スピロ[5.5]ウンデカン−5−オンのフマル酸塩、その薬物としての使用及び調製 |
KR20140096571A (ko) | 2013-01-28 | 2014-08-06 | 한미약품 주식회사 | 1-(4-(4-(3,4-디클로로-2-플루오로페닐아미노)-7-메톡시퀴나졸린-6-일옥시)피페리딘-1-일)프로프-2-엔-1-온의 제조방법 |
HUE034568T2 (en) * | 2013-03-06 | 2018-02-28 | Astrazeneca Ab | Quinazoline inhibitors for inhibiting the activation of mutant forms of epidermal growth factor receptors |
US9242965B2 (en) | 2013-12-31 | 2016-01-26 | Boehringer Ingelheim International Gmbh | Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors |
TWI771327B (zh) * | 2016-10-05 | 2022-07-21 | 英商使命醫療公司 | 新穎化合物 |
AU2020261423A1 (en) | 2019-04-25 | 2021-12-09 | Board Of Regents, The University Of Texas System | Heterocyclic inhibitors of tyrosine kinase |
TW202132281A (zh) | 2019-11-06 | 2021-09-01 | 南韓商柳韓洋行股份有限公司 | 吡咯啶及哌啶類化合物 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5747498A (en) * | 1996-05-28 | 1998-05-05 | Pfizer Inc. | Alkynyl and azido-substituted 4-anilinoquinazolines |
GB9603095D0 (en) * | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline derivatives |
DE19911509A1 (de) * | 1999-03-15 | 2000-09-21 | Boehringer Ingelheim Pharma | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
GB9910577D0 (en) * | 1999-05-08 | 1999-07-07 | Zeneca Ltd | Chemical compounds |
DE10042059A1 (de) * | 2000-08-26 | 2002-03-07 | Boehringer Ingelheim Pharma | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
DE10042058A1 (de) * | 2000-08-26 | 2002-03-07 | Boehringer Ingelheim Pharma | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
TWI324597B (en) * | 2002-03-28 | 2010-05-11 | Astrazeneca Ab | Quinazoline derivatives |
-
2003
- 2003-03-25 JP JP2003579827A patent/JP4776882B2/ja not_active Expired - Fee Related
- 2003-03-25 WO PCT/EP2003/003062 patent/WO2003082290A1/de active Application Filing
- 2003-03-25 AU AU2003226705A patent/AU2003226705B2/en not_active Ceased
- 2003-03-25 PL PL03371188A patent/PL371188A1/xx unknown
- 2003-03-25 RS YUP-854/04A patent/RS85404A/sr unknown
- 2003-03-25 BR BR0308902-9A patent/BR0308902A/pt not_active Expired - Fee Related
- 2003-03-25 ME MEP-472/08A patent/MEP47208A/xx unknown
- 2003-03-25 CA CA2476008A patent/CA2476008C/en not_active Expired - Fee Related
- 2003-03-25 MX MXPA04009536A patent/MXPA04009536A/es active IP Right Grant
- 2003-03-25 IL IL16416703A patent/IL164167A0/xx not_active IP Right Cessation
- 2003-03-25 KR KR1020047015565A patent/KR101064530B1/ko not_active IP Right Cessation
- 2003-03-25 EP EP03745271A patent/EP1492536B1/de not_active Expired - Lifetime
- 2003-03-25 AT AT03745271T patent/ATE557008T1/de active
- 2003-03-25 NZ NZ536114A patent/NZ536114A/en not_active IP Right Cessation
- 2003-03-25 EA EA200401191A patent/EA009300B1/ru not_active IP Right Cessation
- 2003-03-25 EA EA200701302A patent/EA200701302A1/ru unknown
- 2003-03-25 CN CN038072424A patent/CN1642552B/zh not_active Expired - Fee Related
- 2003-03-27 UY UY27737A patent/UY27737A1/es not_active Application Discontinuation
- 2003-03-28 AR ARP030101100A patent/AR039187A1/es not_active Suspension/Interruption
- 2003-03-28 TW TW099102687A patent/TW201024269A/zh unknown
- 2003-03-28 TW TW092107113A patent/TWI331604B/zh not_active IP Right Cessation
- 2003-03-28 MY MYPI20031160A patent/MY127771A/en unknown
- 2003-03-28 PE PE2003000322A patent/PE20040169A1/es not_active Application Discontinuation
-
2004
- 2004-09-23 NO NO20043997A patent/NO329271B1/no not_active IP Right Cessation
- 2004-09-29 HR HR20040898A patent/HRP20040898A2/hr not_active Application Discontinuation
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2005
- 2005-12-02 HK HK05111036.8A patent/HK1079095A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP1492536A1 (de) | 2005-01-05 |
AU2003226705B2 (en) | 2008-11-06 |
AU2003226705A1 (en) | 2003-10-13 |
CA2476008C (en) | 2011-12-13 |
IL164167A0 (en) | 2005-12-18 |
MEP47208A (en) | 2011-02-10 |
AR039187A1 (es) | 2005-02-09 |
UY27737A1 (es) | 2003-10-31 |
ATE557008T1 (de) | 2012-05-15 |
TW201024269A (en) | 2010-07-01 |
WO2003082290A1 (de) | 2003-10-09 |
TW200406211A (en) | 2004-05-01 |
JP2005529090A (ja) | 2005-09-29 |
PL371188A1 (en) | 2005-06-13 |
KR20040094898A (ko) | 2004-11-10 |
NO329271B1 (no) | 2010-09-20 |
PE20040169A1 (es) | 2004-05-24 |
MY127771A (en) | 2006-12-29 |
NO20043997L (no) | 2004-10-27 |
EP1492536B1 (de) | 2012-05-09 |
CA2476008A1 (en) | 2003-10-09 |
KR101064530B1 (ko) | 2011-09-14 |
MXPA04009536A (es) | 2005-01-25 |
JP4776882B2 (ja) | 2011-09-21 |
TWI331604B (en) | 2010-10-11 |
EA009300B1 (ru) | 2007-12-28 |
EA200401191A1 (ru) | 2005-04-28 |
RS85404A (en) | 2007-02-05 |
HK1079095A1 (en) | 2006-03-31 |
HRP20040898A2 (en) | 2005-10-31 |
CN1642552B (zh) | 2010-05-12 |
NZ536114A (en) | 2007-11-30 |
BR0308902A (pt) | 2005-01-04 |
CN1642552A (zh) | 2005-07-20 |
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