TWI605844B - 注射器及其組裝方式 - Google Patents
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
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- A61M2005/247—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened by piercing without internal pressure increase with fixed or steady piercing means, e.g. piercing under movement of ampoule
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- A61M5/178—Syringes
- A61M5/31—Details
- A61M2005/3117—Means preventing contamination of the medicament compartment of a syringe
- A61M2005/3118—Means preventing contamination of the medicament compartment of a syringe via the distal end of a syringe, i.e. syringe end for mounting a needle cannula
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Veterinary Medicine (AREA)
- Vascular Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Mechanical Engineering (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Materials For Medical Uses (AREA)
- Joints Allowing Movement (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361804619P | 2013-03-22 | 2013-03-22 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201507746A TW201507746A (zh) | 2015-03-01 |
| TWI605844B true TWI605844B (zh) | 2017-11-21 |
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| TW103108887A TWI605844B (zh) | 2013-03-22 | 2014-03-13 | 注射器及其組裝方式 |
| TW106134719A TWI635880B (zh) | 2013-03-22 | 2014-03-13 | 注射器及其組裝方式 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW106134719A TWI635880B (zh) | 2013-03-22 | 2014-03-13 | 注射器及其組裝方式 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US10850037B2 (https=) |
| EP (2) | EP2976117B1 (https=) |
| JP (3) | JP6670740B2 (https=) |
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| CN (2) | CN105377327B (https=) |
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Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7959598B2 (en) | 2008-08-20 | 2011-06-14 | Asante Solutions, Inc. | Infusion pump systems and methods |
| ES2675035T3 (es) | 2011-10-14 | 2018-07-05 | Amgen, Inc | Inyector y método de ensamblaje |
| HUE067982T2 (hu) | 2012-03-30 | 2024-12-28 | Insulet Corp | Folyadékadagoló készülék transzkután beviteli eszközzel, behelyezõ mechanizmussal és vércukor monitorozással |
| IL292270B2 (en) * | 2013-03-22 | 2024-04-01 | Amgen Inc | Injector and method of assembly |
| US9561324B2 (en) | 2013-07-19 | 2017-02-07 | Bigfoot Biomedical, Inc. | Infusion pump system and method |
| MX373358B (es) * | 2013-10-24 | 2020-07-06 | Amgen Inc | Inyector y método de montaje. |
| MA41101A (fr) * | 2014-12-03 | 2017-10-10 | Lilly Co Eli | Dispositif d'injection de médicament automatique comportant une indication audible de progression d'injection |
| CN107635527B (zh) * | 2015-03-10 | 2021-04-23 | 里珍纳龙药品有限公司 | 无菌刺穿系统和方法 |
| US10275573B2 (en) | 2016-01-13 | 2019-04-30 | Bigfoot Biomedical, Inc. | User interface for diabetes management system |
| US10806859B2 (en) | 2016-01-14 | 2020-10-20 | Bigfoot Biomedical, Inc. | Adjusting insulin delivery rates |
| HK1256995A1 (zh) | 2016-01-14 | 2019-10-11 | Bigfoot Biomedical, Inc. | 药物输送设备、系统和方法中的阻塞解决方案 |
| JOP20170042B1 (ar) | 2016-02-12 | 2022-09-15 | Amgen Inc | وسيلة توصيل عقار، طريقة تصنيعه وطريقة استخدامه |
| WO2017177094A2 (en) | 2016-04-08 | 2017-10-12 | Amgen Inc. | Drug delivery device, method of manufacture, and method of use |
| US11238150B2 (en) | 2016-05-16 | 2022-02-01 | Amgen Inc. | Data encryption in medical devices with limited computational capability |
| US12383166B2 (en) | 2016-05-23 | 2025-08-12 | Insulet Corporation | Insulin delivery system and methods with risk-based set points |
| US10363374B2 (en) | 2016-05-26 | 2019-07-30 | Insulet Corporation | Multi-dose drug delivery device |
| US10363372B2 (en) | 2016-08-12 | 2019-07-30 | Insulet Corporation | Plunger for drug delivery device |
| EP3730169B1 (en) | 2016-08-14 | 2023-08-02 | Insulet Corporation | Drug delivery device with detection of position of the plunger |
| WO2018067645A1 (en) * | 2016-10-07 | 2018-04-12 | Insulet Corporation | Multi-stage delivery system |
| US10780217B2 (en) | 2016-11-10 | 2020-09-22 | Insulet Corporation | Ratchet drive for on body delivery system |
| CA3037432A1 (en) | 2016-12-12 | 2018-06-21 | Bigfoot Biomedical, Inc. | Alarms and alerts for medication delivery devices and related systems and methods |
| EP4708311A2 (en) | 2017-01-13 | 2026-03-11 | Insulet Corporation | Insulin delivery methods, systems and devices |
| US10758675B2 (en) | 2017-01-13 | 2020-09-01 | Bigfoot Biomedical, Inc. | System and method for adjusting insulin delivery |
| US10500334B2 (en) | 2017-01-13 | 2019-12-10 | Bigfoot Biomedical, Inc. | System and method for adjusting insulin delivery |
| EP3568860B1 (en) | 2017-01-13 | 2025-12-10 | Insulet Corporation | Insulin delivery methods, systems and devices |
| US10881793B2 (en) | 2017-01-13 | 2021-01-05 | Bigfoot Biomedical, Inc. | System and method for adjusting insulin delivery |
| US10583250B2 (en) | 2017-01-13 | 2020-03-10 | Bigfoot Biomedical, Inc. | System and method for adjusting insulin delivery |
| US10603440B2 (en) | 2017-01-19 | 2020-03-31 | Insulet Corporation | Cartridge hold-up volume reduction |
| US10695485B2 (en) | 2017-03-07 | 2020-06-30 | Insulet Corporation | Very high volume user filled drug delivery device |
| KR102540409B1 (ko) | 2017-05-05 | 2023-06-09 | 리제너론 파아마슈티컬스, 인크. | 자동 주사기 |
| EP4375504B1 (en) | 2017-08-03 | 2026-04-15 | Insulet Corporation | Micro piston pump |
| US10973978B2 (en) | 2017-08-03 | 2021-04-13 | Insulet Corporation | Fluid flow regulation arrangements for drug delivery devices |
| US11786668B2 (en) | 2017-09-25 | 2023-10-17 | Insulet Corporation | Drug delivery devices, systems, and methods with force transfer elements |
| USD928199S1 (en) | 2018-04-02 | 2021-08-17 | Bigfoot Biomedical, Inc. | Medication delivery device with icons |
| US12562251B1 (en) | 2018-05-09 | 2026-02-24 | Bigfoot Biomedical, Inc. | Computing architecture for assuring the provenance of medication therapy related parameters, and related systems, methods and devices |
| US10874803B2 (en) | 2018-05-31 | 2020-12-29 | Insulet Corporation | Drug cartridge with drive system |
| US11229736B2 (en) | 2018-06-06 | 2022-01-25 | Insulet Corporation | Linear shuttle pump for drug delivery |
| AU2019390474B2 (en) | 2018-11-28 | 2023-03-30 | Insulet Corporation | Drug delivery shuttle pump system and valve assembly |
| USD920343S1 (en) | 2019-01-09 | 2021-05-25 | Bigfoot Biomedical, Inc. | Display screen or portion thereof with graphical user interface associated with insulin delivery |
| AU2020356529A1 (en) | 2019-09-25 | 2022-05-19 | Janssen Pharmaceuticals, Inc. | Interconnection of drug administration systems |
| US11369735B2 (en) | 2019-11-05 | 2022-06-28 | Insulet Corporation | Component positioning of a linear shuttle pump |
| EP3939896A1 (de) * | 2020-07-17 | 2022-01-19 | Pharma Integration S.R.L. | Funktionsmodul zum heranführen an eine in einem prozessraum eines containments positionierte dosierstation und verfahren dazu |
| JP7665028B2 (ja) | 2020-12-18 | 2025-04-18 | インスレット コーポレイション | 薬物送達デバイスによる将来の日付および時刻における薬物ボーラス送達の、コンピューティングデバイスを用いたスケジュール設定 |
| EP4274640A1 (en) | 2021-01-08 | 2023-11-15 | Insulet Corporation | Single actuated precision dose intermediate pumping chamber |
| US12440617B2 (en) | 2021-01-11 | 2025-10-14 | Insulet Corporation | Linear activated drug dosing pump system |
| US11872369B1 (en) | 2021-02-18 | 2024-01-16 | Fresenius Kabi Deutschland Gmbh | Wearable medicament delivery device with leakage and skin contact sensing and method of use thereof |
| US11311666B1 (en) | 2021-02-18 | 2022-04-26 | Fresenius Kabi Deutschland Gmbh | Modular wearable medicament delivery device and method of use thereof |
| US11464902B1 (en) | 2021-02-18 | 2022-10-11 | Fresenius Kabi Deutschland Gmbh | Wearable medicament delivery device with compressible reservoir and method of use thereof |
| US11406755B1 (en) | 2021-02-19 | 2022-08-09 | Fresenius Kabi Deutschland Gmbh | Sensing fluid flow irregularities in an on-body injector |
| US11413394B1 (en) | 2021-02-19 | 2022-08-16 | Fresenius Kabi Deutschland Gmbh | Display for wearable drug delivery device |
| US11607505B1 (en) | 2021-02-19 | 2023-03-21 | Fresenius Kabi Deutschland Gmbh | Wearable injector with sterility sensors |
| US11633537B1 (en) | 2021-02-19 | 2023-04-25 | Fresenius Kabi Deutschland Gmbh | Drug delivery assembly including a pre-filled cartridge |
| US11426523B1 (en) | 2021-02-19 | 2022-08-30 | Fresenius Kabi Deutschland Gmbh | Drug delivery assembly including a removable cartridge |
| US11344682B1 (en) | 2021-02-19 | 2022-05-31 | Fresenius Kabi Deutschland Gmbh | Drug supply cartridge with visual use indicator and delivery devices that use the same |
| US11497847B1 (en) | 2021-02-19 | 2022-11-15 | Fresenius Kabi Deutschland Gmbh | Wearable injector with adhesive substrate |
| US11529459B1 (en) | 2021-04-30 | 2022-12-20 | Fresenius Kabi Deutschland Gmbh | Wearable injector with adhesive module |
| US20240216664A1 (en) * | 2021-04-30 | 2024-07-04 | Neurochase Technologies Limited | Neurosurgical device |
| US11351300B1 (en) | 2021-04-30 | 2022-06-07 | Fresenius Kabl Deutschland GmbH | Drug dispensing system with replaceable drug supply cartridges |
| US11504470B1 (en) | 2021-04-30 | 2022-11-22 | Fresenius Kabi Deutschland Gmbh | Deformable drug reservoir for wearable drug delivery device |
| US11419976B1 (en) | 2021-04-30 | 2022-08-23 | Fresenius Kabi Deutschland Gmbh | Wearable drug delivery device with pressurized fluid dispensing |
| US11717608B1 (en) | 2021-05-03 | 2023-08-08 | Fresenius Kabi Deutschland Gmbh | Drug delivery assembly including an adhesive pad |
| US11484646B1 (en) | 2021-05-04 | 2022-11-01 | Fresenius Kabi Deutschland Gmbh | Sealing systems for a reservoir of an on-body injector |
| US12594376B2 (en) | 2021-05-21 | 2026-04-07 | Insulet Corporation | Compact positive displacement pump for wearable drug delivery device |
| US12359903B2 (en) | 2021-05-28 | 2025-07-15 | Insulet Corporation | Spring-based status sensors |
| US12514980B2 (en) | 2021-06-30 | 2026-01-06 | Insulet Corporation | Adjustment of medicament delivery by a medicament delivery device based on menstrual cycle phase |
| US12521486B2 (en) | 2021-07-16 | 2026-01-13 | Insulet Corporation | Method for modification of insulin delivery during pregnancy in automatic insulin delivery systems |
| USD1007676S1 (en) | 2021-11-16 | 2023-12-12 | Regeneron Pharmaceuticals, Inc. | Wearable autoinjector |
| CN120457493A (zh) | 2023-01-06 | 2025-08-08 | 英赛罗公司 | 自动或手动启动的随餐推注输送及随后的自动安全约束放宽 |
Family Cites Families (437)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2371086A (en) | 1940-11-14 | 1945-03-06 | Watson | Hypodermic injector |
| US2627270A (en) * | 1946-02-09 | 1953-02-03 | Antonina S Glass | Self-propelled automatic syringe |
| US2591706A (en) | 1950-09-29 | 1952-04-08 | Compule Corp | Plural-compartment admixing hypodermic syringe ampoule for segregated storage of ingredients of liquid medicinal solutions and therapeutic preparations |
| GB718837A (en) | 1951-07-18 | 1954-11-24 | Cook Waite Lab Inc | Improvements in or relating to hypodermic syringe |
| GB722166A (en) | 1951-10-25 | 1955-01-19 | Pfizer & Co C | Improvements in or relating to disposable cartridge for hypodermic syringe |
| BE515202A (https=) | 1951-11-01 | |||
| US2677373A (en) | 1952-05-19 | 1954-05-04 | P M Ind Inc | Plastic injection device |
| US2688967A (en) | 1953-06-02 | 1954-09-14 | Huber Jennie | Metal aspirating syringe |
| US2842126A (en) | 1954-03-16 | 1958-07-08 | Frederick M Turnbull | Syringe assembly |
| GB989185A (en) | 1961-08-25 | 1965-04-14 | Glaxo Group Ltd | Improvements in or relating to hypodermic syringes |
| US3187749A (en) | 1962-01-04 | 1965-06-08 | Stanley J Sarnoff | Hypodermic cartridge |
| US3336924A (en) | 1964-02-20 | 1967-08-22 | Sarnoff | Two compartment syringe package |
| US3342180A (en) | 1964-04-24 | 1967-09-19 | American Cyanamid Co | Disposable liquid-powder package and hypodermic syringe |
| DK108590C (da) | 1964-05-28 | 1968-01-08 | Novo Terapeutisk Labor As | Sprøjteampul. |
| US3368558A (en) | 1964-08-21 | 1968-02-13 | Sarnoff | Two compartment cartridge |
| GB1159665A (en) | 1965-07-23 | 1969-07-30 | Robert Walter Ogle | Improvements in or relating to Component Parts for Medicament Injectors |
| US3378008A (en) | 1965-07-23 | 1968-04-16 | Min I Jet Corp | Hypodermic syringe with vial |
| US3557787A (en) * | 1968-05-28 | 1971-01-26 | Milton J Cohen | Disposable syringe |
| US3605744A (en) * | 1969-04-22 | 1971-09-20 | Edward M Dwyer | Injection apparatus and method of injecting |
| AT318132B (de) | 1969-08-01 | 1974-09-25 | Dentaire Ivoclar Ets | Mischbehälter für die Aufnahme von miteinander reagierenden Substanzen für die Herstellung von gebrauchsfertigen pastenförmigen Dentalpräparaten |
| BE757195A (fr) | 1969-10-07 | 1971-03-16 | Century Disposable Devices | Seringue servant a injecter un melange fraichement prepare de poudre etde liquide |
| US3640278A (en) | 1969-10-13 | 1972-02-08 | Benjamin Friedman | Hypodermic syringe device which maintains sterile condition of needle |
| US3739779A (en) | 1970-04-28 | 1973-06-19 | Medical Electroscience & Pharm | Hypodermic syringe and needle construction |
| US3662753A (en) | 1970-05-25 | 1972-05-16 | Kitchener B Tassell | Syringe |
| US3757779A (en) | 1971-05-24 | 1973-09-11 | Century Labor Inc | Filter syringe |
| US3872867A (en) | 1971-06-02 | 1975-03-25 | Upjohn Co | Wet-dry additive assembly |
| US3785379A (en) | 1971-08-12 | 1974-01-15 | M Cohen | Syringe for injection of freshly mixed liquid-powder |
| US3835855A (en) | 1972-10-10 | 1974-09-17 | C Barr | Multi-chambered syringe |
| US3825003A (en) | 1972-12-26 | 1974-07-23 | Vca Metal Fab Inc | Sealed-hypodermic syringe |
| DE2315367A1 (de) | 1973-03-28 | 1974-10-17 | Hoechst Ag | Injektionsspritze zur einmaligen verwendung |
| US3872864A (en) | 1973-07-06 | 1975-03-25 | Jr Robert E Allen | Double syringe |
| DE2434046C3 (de) | 1974-07-16 | 1979-10-18 | Lothar 7500 Karlsruhe Schwarz | Nadelhalterung für medizinische Spritzen |
| NL173477C (nl) | 1974-09-12 | 1984-02-01 | Duphar Int Res | Injektiespuit met teleskopisch orgaan tussen patroon en medicamentflesje. |
| US4055177A (en) | 1976-05-28 | 1977-10-25 | Cohen Milton J | Hypodermic syringe |
| US4188949A (en) | 1977-07-05 | 1980-02-19 | Becton, Dickinson & Company | Sequential injection syringe |
| US4215689A (en) | 1977-07-27 | 1980-08-05 | Koken Co., Ltd. | Injecting apparatus for medical liquid |
| US4178930A (en) | 1977-10-31 | 1979-12-18 | Fisher Frank R Jr | Combined cap and needle structure |
| AT360139B (de) | 1978-10-16 | 1980-12-29 | Immuno Ag | Kombinierte ampullen-einweg-injektionsspritze |
| US4196732A (en) * | 1978-12-26 | 1980-04-08 | Wardlaw Stephen C | Automatic disposable syringe and method of filling the same |
| US4296786A (en) | 1979-09-28 | 1981-10-27 | The West Company | Transfer device for use in mixing a primary solution and a secondary or additive substance |
| US4411163A (en) | 1981-07-27 | 1983-10-25 | American Hospital Supply Corporation | Ventable sample collection device |
| JPS5831673A (ja) | 1981-08-20 | 1983-02-24 | Sanyo Electric Co Ltd | 固体撮像素子 |
| NZ210501A (en) | 1983-12-13 | 1991-08-27 | Kirin Amgen Inc | Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence |
| KR850004274A (ko) | 1983-12-13 | 1985-07-11 | 원본미기재 | 에리트로포이에틴의 제조방법 |
| US4703008A (en) | 1983-12-13 | 1987-10-27 | Kiren-Amgen, Inc. | DNA sequences encoding erythropoietin |
| IT1173370B (it) | 1984-02-24 | 1987-06-24 | Erba Farmitalia | Dispositivo di sicurezza per collegare una siringa alla imboccatura di un flacone contenente un farmaco o di un tubicino per l'erogazione del farmaco della siringa |
| US4523679A (en) | 1984-03-05 | 1985-06-18 | Sterling Drug Inc. | Pre-sterilized medical procedure kit packages |
| US4619651A (en) | 1984-04-16 | 1986-10-28 | Kopfer Rudolph J | Anti-aerosoling drug reconstitution device |
| US4626244A (en) | 1985-02-01 | 1986-12-02 | Consolidated Controls Corporation | Implantable medication infusion device |
| GB8509301D0 (en) | 1985-04-11 | 1985-05-15 | Clinical Products Dev Ltd | Device for surgical procedures |
| DE3514815A1 (de) | 1985-04-24 | 1986-11-06 | Bayerische Motoren Werke AG, 8000 München | Unabhaengige fahrzeug-radaufhaengung |
| US4838857A (en) | 1985-05-29 | 1989-06-13 | Becton, Dickinson And Company | Medical infusion device |
| US4632672A (en) | 1985-10-07 | 1986-12-30 | Minnesota Mining And Manufacturing Company | Self venting syringe plunger |
| FR2589738A1 (fr) | 1985-11-14 | 1987-05-15 | Lascar Marcel | Seringue a double chambre |
| US4655747A (en) | 1986-01-30 | 1987-04-07 | Allen Jr Robert E | Dual chambered syringe |
| FR2604363A1 (fr) * | 1986-09-30 | 1988-04-01 | Merieux Inst | Dispositif d'injection de substances, notamment medicamenteuses |
| US4883473A (en) | 1987-04-29 | 1989-11-28 | Path | Single use injection device |
| ES1002629Y (es) | 1987-06-05 | 1989-01-16 | Badia Marcelo Segura | Conexion para cateteres, equipos de perfusion y frascos de liquidos a perfundir |
| US5364369A (en) * | 1987-07-08 | 1994-11-15 | Reynolds David L | Syringe |
| CH673775A5 (https=) | 1987-07-10 | 1990-04-12 | Jacques Verlier | |
| US4784156A (en) | 1987-09-16 | 1988-11-15 | Garg Rakesh K | Cannula including a valve structure and associated instrument elements and method for using same |
| US5135489A (en) | 1988-01-25 | 1992-08-04 | Baxter International Inc. | Pre-slit injection site and tapered cannula |
| US4915690A (en) | 1988-02-02 | 1990-04-10 | C. R. Bard, Inc. | Micro-injection port |
| IE65903B1 (en) | 1989-06-02 | 1995-11-29 | Becton Dickinson Co | Syringe assembly |
| US5019047A (en) | 1989-06-16 | 1991-05-28 | Science Incorporated | Fluid delivery apparatus |
| US5205820A (en) | 1989-06-16 | 1993-04-27 | Science, Incorporated | Fluid delivery apparatus |
| US5716343A (en) | 1989-06-16 | 1998-02-10 | Science Incorporated | Fluid delivery apparatus |
| US7217689B1 (en) | 1989-10-13 | 2007-05-15 | Amgen Inc. | Glycosylation analogs of erythropoietin |
| US5856298A (en) | 1989-10-13 | 1999-01-05 | Amgen Inc. | Erythropoietin isoforms |
| AU646822B2 (en) | 1989-10-13 | 1994-03-10 | Kirin-Amgen Inc. | Erythropoietin isoforms |
| JPH03168154A (ja) | 1989-11-29 | 1991-07-19 | Ajinomoto Takara Corp:Kk | 注射器 |
| US5078691A (en) | 1990-03-01 | 1992-01-07 | Hamacher Edward N | Multiple-dose fluid delivery system and method |
| US5334197A (en) | 1990-09-25 | 1994-08-02 | Science Incorporated | Flexible base fluid delivery apparatus |
| SE9101022D0 (sv) | 1991-01-09 | 1991-04-08 | Paal Svedman | Medicinsk suganordning |
| US5593391A (en) | 1992-02-13 | 1997-01-14 | Stanners; Sydney D. | Ampule safety syringe |
| US5267974A (en) * | 1992-06-04 | 1993-12-07 | Lambert William S | Hypodermic syringe with foam sponge reservoir |
| US5807323A (en) | 1992-08-13 | 1998-09-15 | Science Incorporated | Mixing and delivery syringe assembly |
| CH689443A5 (fr) | 1992-09-16 | 1999-04-30 | Debiotech Sa | Ensemble constituant une pompe à usage médical. |
| US5250037A (en) | 1992-12-18 | 1993-10-05 | Becton, Dickinson And Company | Syringe having needle isolation features |
| US5312336A (en) | 1993-04-14 | 1994-05-17 | Habley Medical Technology Corporation | Component mixing syringe |
| CN1057534C (zh) | 1993-08-17 | 2000-10-18 | 柯瑞英-艾格公司 | 促红细胞生成素类似物 |
| US5665066A (en) | 1993-09-03 | 1997-09-09 | Ultradent Products, Inc. | Methods and apparatus for mixing and dispensing multi-part compositions |
| US5358491A (en) | 1993-09-13 | 1994-10-25 | Sterling Winthrop Inc. | Cartridge-needle unit having retractable needle |
| JPH07124256A (ja) | 1993-10-29 | 1995-05-16 | Ajinomoto Takara Corp:Kk | 注射器 |
| US5620425A (en) * | 1993-11-03 | 1997-04-15 | Bracco International B.V. | Method for the preparation of pre-filled plastic syringes |
| US5773569A (en) | 1993-11-19 | 1998-06-30 | Affymax Technologies N.V. | Compounds and peptides that bind to the erythropoietin receptor |
| US5830851A (en) | 1993-11-19 | 1998-11-03 | Affymax Technologies N.V. | Methods of administering peptides that bind to the erythropoietin receptor |
| US5885574A (en) | 1994-07-26 | 1999-03-23 | Amgen Inc. | Antibodies which activate an erythropoietin receptor |
| DE69507088T2 (de) | 1994-07-27 | 1999-05-27 | Meridian Medical Technologies, Inc., Columbia, Md. | Automatische Spritze |
| ES2251723T3 (es) | 1994-08-12 | 2006-05-01 | Immunomedics, Inc. | Inmunoconjugados y anticuerpos humanizados especificos para linfoma de celulas b y celulas de leucemia. |
| US5496284A (en) | 1994-09-27 | 1996-03-05 | Waldenburg; Ottfried | Dual-chamber syringe & method |
| US5624402A (en) | 1994-12-12 | 1997-04-29 | Becton, Dickinson And Company | Syringe tip cap |
| US5962794A (en) | 1995-05-01 | 1999-10-05 | Science Incorporated | Fluid delivery apparatus with reservior fill assembly |
| US5618269A (en) | 1995-05-04 | 1997-04-08 | Sarcos, Inc. | Pressure-driven attachable topical fluid delivery system |
| US5686292A (en) | 1995-06-02 | 1997-11-11 | Genentech, Inc. | Hepatocyte growth factor receptor antagonist antibodies and uses thereof |
| US5767078A (en) | 1995-06-07 | 1998-06-16 | Johnson; Dana L. | Agonist peptide dimers |
| US5921962A (en) | 1995-10-11 | 1999-07-13 | Science Incorporated | Fluid delivery device with flow indicator and rate control |
| US5693018A (en) | 1995-10-11 | 1997-12-02 | Science Incorporated | Subdermal delivery device |
| US5957891A (en) | 1995-10-11 | 1999-09-28 | Science Incorporated | Fluid delivery device with fill adapter |
| US5735818A (en) | 1995-10-11 | 1998-04-07 | Science Incorporated | Fluid delivery device with conformable ullage |
| AT404556B (de) | 1995-11-23 | 1998-12-28 | Pharma Consult Gmbh | Einrichtung zum dichten verschliessen eines glas- oder kunststoffbehälters zur aufnahme flüssiger pharmazeutischer produkte |
| US5749857A (en) | 1996-04-25 | 1998-05-12 | Cuppy; Michael J. | Catheter system |
| US5865744A (en) | 1996-09-16 | 1999-02-02 | Lemelson; Jerome H. | Method and system for delivering therapeutic agents |
| US5840071A (en) | 1996-12-18 | 1998-11-24 | Science Incorporated | Fluid delivery apparatus with flow indicator and vial fill |
| US6355019B1 (en) | 1996-12-18 | 2002-03-12 | Science Incorporated | Variable rate infusion apparatus with indicator and adjustable rate control |
| DE19652708C2 (de) * | 1996-12-18 | 1999-08-12 | Schott Glas | Verfahren zum Herstellen eines befüllten Kunststoff-Spritzenkorpus für medizinische Zwecke |
| US6500150B1 (en) * | 1997-06-16 | 2002-12-31 | Elan Pharma International Limited | Pre-filled drug-delivery device and method of manufacture and assembly of same |
| WO1998057683A1 (en) | 1997-06-16 | 1998-12-23 | Elan Corporation, Plc. | Pre-filled drug-delivery device and method of manufacture and assembly of same |
| US6753165B1 (en) | 1999-01-14 | 2004-06-22 | Bolder Biotechnology, Inc. | Methods for making proteins containing free cysteine residues |
| ATE375363T1 (de) | 1997-07-14 | 2007-10-15 | Bolder Biotechnology Inc | Derivate des wachstumshormons und verwandte proteine |
| PT986644E (pt) | 1997-07-23 | 2007-01-31 | Roche Diagnostics Gmbh | Preparação de eritropoietina por activação genética endógena com promotores virais |
| US5921966A (en) | 1997-08-11 | 1999-07-13 | Becton Dickinson And Company | Medication delivery pen having an improved clutch assembly |
| US6482176B1 (en) | 1997-11-27 | 2002-11-19 | Disetronic Licensing Ag | Method and device for controlling the introduction depth of an injection needle |
| US5957895A (en) | 1998-02-20 | 1999-09-28 | Becton Dickinson And Company | Low-profile automatic injection device with self-emptying reservoir |
| US6248095B1 (en) | 1998-02-23 | 2001-06-19 | Becton, Dickinson And Company | Low-cost medication delivery pen |
| US6030086A (en) | 1998-03-02 | 2000-02-29 | Becton, Dickinson And Company | Flash tube reflector with arc guide |
| US6221055B1 (en) | 1998-03-04 | 2001-04-24 | Retractable Technologies, Inc. | Retractable dental syringe |
| AU3001299A (en) | 1998-03-13 | 1999-09-27 | Becton Dickinson & Company | Method for manufacturing, filling and packaging medical containers |
| WO1999048546A1 (en) | 1998-03-23 | 1999-09-30 | Elan Corporation, Plc | Drug delivery device |
| US6310078B1 (en) | 1998-04-20 | 2001-10-30 | Ortho-Mcneil Pharmaceutical, Inc. | Substituted amino acids as erythropoietin mimetics |
| US20050181482A1 (en) | 2004-02-12 | 2005-08-18 | Meade Harry M. | Method for the production of an erythropoietin analog-human IgG fusion proteins in transgenic mammal milk |
| ATE339507T1 (de) | 1998-06-15 | 2006-10-15 | Gtc Biotherapeutics Inc | Erythropoietin-analog-menschliches serum-albumin fusionsprotein |
| PT1813624E (pt) | 1998-10-23 | 2010-10-27 | Amgen Inc | Métodos e composições para a prevenção e tratamento da anemia |
| PT1783222E (pt) | 1998-10-23 | 2012-07-26 | Kirin Amgen Inc | Péptidos diméricos de trombopoietina que simulam a ligação ao receptor mpl e têm actividade trombopoiética |
| CA2669175C (en) | 1998-10-29 | 2014-01-28 | Medtronic Minimed, Inc. | Reservoir connector |
| DE69933044T3 (de) | 1998-11-27 | 2016-11-24 | Ucb Pharma, S.A. | Zusammensetzungen und verfahren zur erhöhung der knochenmineralisierung |
| EP1006184A1 (en) | 1998-12-03 | 2000-06-07 | F. Hoffmann-La Roche Ag | IGF-1 receptor interacting proteins (IIPs) genes coding therefor and uses thereof |
| DE19909824A1 (de) * | 1999-03-05 | 2000-09-07 | Vetter & Co Apotheker | Spritze für medizinische Zwecke und Verfahren zu ihrer Montage |
| WO2000061637A1 (en) | 1999-04-14 | 2000-10-19 | Smithkline Beecham Corporation | Erythropoietin receptor antibodies |
| US7297680B2 (en) | 1999-04-15 | 2007-11-20 | Crucell Holland B.V. | Compositions of erythropoietin isoforms comprising Lewis-X structures and high sialic acid content |
| ES2251371T3 (es) | 1999-04-16 | 2006-05-01 | Becton Dickinson And Company | Inyector de tipo pluma con caracteristicas de combinacion de sustancias automatizada. |
| CZ299516B6 (cs) | 1999-07-02 | 2008-08-20 | F. Hoffmann-La Roche Ag | Konjugát erythropoetinového glykoproteinu, zpusobjeho výroby a použití a farmaceutická kompozice sjeho obsahem |
| DE19939936A1 (de) | 1999-08-23 | 2001-03-08 | Beru Ag | Einrichtung zum Überwachen und drahtlosen Signalisieren des Drucks in Luftreifen an Fahrzeugen |
| US6491667B1 (en) | 1999-08-31 | 2002-12-10 | Becton, Dickinson And Company | Syringe tip cap |
| US6840291B2 (en) | 1999-10-15 | 2005-01-11 | Becton Dickinson And Company | Attachment for a medical device |
| DE60037531T2 (de) | 1999-10-22 | 2008-12-11 | ANTARES PHARMA, Inc., Minneapolis | Medikamentenkartusche und injektionsvorrichtung |
| AU1099601A (en) | 1999-10-22 | 2001-05-08 | Millennium Pharmaceuticals, Inc. | Nucleic acid molecules derived from rat brain and programmed cell death models |
| US7063684B2 (en) | 1999-10-28 | 2006-06-20 | Medtronic Minimed, Inc. | Drive system seal |
| US20050202538A1 (en) | 1999-11-12 | 2005-09-15 | Merck Patent Gmbh | Fc-erythropoietin fusion protein with improved pharmacokinetics |
| EP1228214A2 (en) | 1999-11-12 | 2002-08-07 | MERCK PATENT GmbH | Erythropoietin forms with improved properties |
| AUPQ526100A0 (en) * | 2000-01-25 | 2000-02-17 | Ferrier International Limited | Improvements in single use syringes |
| US7243689B2 (en) | 2000-02-11 | 2007-07-17 | Medical Instill Technologies, Inc. | Device with needle penetrable and laser resealable portion and related method |
| AUPQ599700A0 (en) | 2000-03-03 | 2000-03-23 | Super Internet Site System Pty Ltd | On-line geographical directory |
| US6586398B1 (en) | 2000-04-07 | 2003-07-01 | Amgen, Inc. | Chemically modified novel erythropoietin stimulating protein compositions and methods |
| WO2001081405A2 (en) | 2000-04-21 | 2001-11-01 | Amgen Inc. | Methods and compositions for the prevention and treatment of anemia |
| US6756480B2 (en) | 2000-04-27 | 2004-06-29 | Amgen Inc. | Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein |
| US6589229B1 (en) | 2000-07-31 | 2003-07-08 | Becton, Dickinson And Company | Wearable, self-contained drug infusion device |
| US7078376B1 (en) | 2000-08-11 | 2006-07-18 | Baxter Healthcare S.A. | Therapeutic methods for treating subjects with a recombinant erythropoietin having high activity and reduced side effects |
| EE200300089A (et) | 2000-09-08 | 2005-02-15 | Gryphon Therapeutics, Inc. | Sünteetilised erütropoeesi stimuleerivad valgud, nende valmistamismeetodid ning kasutamine |
| US7621887B2 (en) | 2000-10-10 | 2009-11-24 | Meridian Medical Technologies, Inc. | Wet/dry automatic injector assembly |
| US7271689B1 (en) | 2000-11-22 | 2007-09-18 | Fonar Corporation | Magnet structure |
| US6537249B2 (en) | 2000-12-18 | 2003-03-25 | Science, Incorporated | Multiple canopy |
| DE60144439D1 (de) | 2000-12-20 | 2011-05-26 | Hoffmann La Roche | Konjugate von erythropoietin (epo) mit polyethylenglykol (peg) |
| BRPI0116728B1 (pt) | 2001-01-05 | 2018-10-30 | Pfizer Inc. | anticorpos para receptor de fator de crescimento i semelhante à insulina |
| US20020139088A1 (en) | 2001-03-08 | 2002-10-03 | Archie Woodworth | Polymeric syringe body and stopper |
| CA2440886A1 (en) | 2001-03-15 | 2002-09-26 | Mdc Investment Holdings, Inc. | Retractable needle medical device for injecting fluid from a pre-filled cartridge |
| FR2822710B1 (fr) * | 2001-03-27 | 2004-04-02 | Lab Contactologie Appl Lca | Seringue pour solutions viscoleastiques |
| DE60232870D1 (de) | 2001-04-04 | 2009-08-20 | Genodyssee | Neue polynukleotide und polypeptide des erythropoietingens |
| ATE549354T1 (de) | 2001-05-11 | 2012-03-15 | Amgen Inc | Peptide und damit zusammenhängende an tall-1 bindende moleküle |
| US20120209197A1 (en) | 2002-01-04 | 2012-08-16 | Lanigan Richard J | Infusion pump assembly |
| US8034026B2 (en) | 2001-05-18 | 2011-10-11 | Deka Products Limited Partnership | Infusion pump assembly |
| PH12012502440A1 (en) | 2001-06-26 | 2013-06-17 | Amgen Inc | Antibodies to opgl |
| US6900292B2 (en) | 2001-08-17 | 2005-05-31 | Lee-Hwei K. Sun | Fc fusion proteins of human erythropoietin with increased biological activities |
| JP4838955B2 (ja) | 2001-08-21 | 2011-12-14 | 武田薬品工業株式会社 | 2室型プレフィルドシリンジ |
| IL160358A0 (en) | 2001-08-23 | 2004-07-25 | Genmab As | Human antibodies specific for interleukin 15 (il-15) |
| US7247304B2 (en) | 2001-08-23 | 2007-07-24 | Genmab A/S | Methods of treating using anti-IL-15 antibodies |
| US20030055380A1 (en) | 2001-09-19 | 2003-03-20 | Flaherty J. Christopher | Plunger for patient infusion device |
| US7112188B2 (en) | 2001-09-25 | 2006-09-26 | Ottfried Waldenburg | Medication capsule, syringe used with medication capsule and method of administrating medication |
| US6930086B2 (en) | 2001-09-25 | 2005-08-16 | Hoffmann-La Roche Inc. | Diglycosylated erythropoietin |
| US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
| US7521053B2 (en) | 2001-10-11 | 2009-04-21 | Amgen Inc. | Angiopoietin-2 specific binding agents |
| US7138370B2 (en) | 2001-10-11 | 2006-11-21 | Amgen Inc. | Specific binding agents of human angiopoietin-2 |
| US20040078028A1 (en) * | 2001-11-09 | 2004-04-22 | Flaherty J. Christopher | Plunger assembly for patient infusion device |
| US6802828B2 (en) | 2001-11-23 | 2004-10-12 | Duoject Medical Systems, Inc. | System for filling and assembling pharmaceutical delivery devices |
| WO2003055526A2 (en) | 2001-12-21 | 2003-07-10 | Maxygen Aps | Erythropoietin conjugates |
| DE60312639T2 (de) | 2002-01-18 | 2007-11-29 | Pierre Fabre Médicament | Antikörper gegen igf-ir und ihre verwendungen |
| US7241444B2 (en) | 2002-01-18 | 2007-07-10 | Pierre Fabre Medicament | Anti-IGF-IR antibodies and uses thereof |
| GB0202252D0 (en) | 2002-01-31 | 2002-03-20 | Oxford Biomedica Ltd | Anemia |
| EP1470232A1 (en) | 2002-01-31 | 2004-10-27 | Oxford Biomedica (UK) Limited | Physiologically regulated erythropoietin-expressing vector for the treatment of anaemia |
| US6828908B2 (en) | 2002-02-06 | 2004-12-07 | Ronald Scott Clark | Locator system with an implanted transponder having an organically-rechargeable battery |
| KR100507593B1 (ko) | 2002-02-08 | 2005-08-10 | 주식회사 이화양행 | 액체공급장치 |
| ATE363541T1 (de) | 2002-03-26 | 2007-06-15 | Lek Tovarna Farmacevtskih | Verfahren für die herstellung eines gewünschten profils von erythropoietin glyko-isoformen |
| CA2480727C (en) | 2002-03-29 | 2010-06-01 | Kumiai Chemical Industry Co., Ltd. | Gene coding for acetolactate synthase |
| WO2003084477A2 (en) | 2002-03-29 | 2003-10-16 | Centocor, Inc. | Mammalian cdr mimetibodies, compositions, methods and uses |
| US6808507B2 (en) | 2002-05-10 | 2004-10-26 | Cambridge Biostability Ltd. | Safety injectors |
| US20040009902A1 (en) | 2002-05-13 | 2004-01-15 | Irving Boime | CTP extended erythropoietin |
| US7217796B2 (en) | 2002-05-24 | 2007-05-15 | Schering Corporation | Neutralizing human anti-IGFR antibody |
| US8034904B2 (en) | 2002-06-14 | 2011-10-11 | Immunogen Inc. | Anti-IGF-I receptor antibody |
| US7538195B2 (en) | 2002-06-14 | 2009-05-26 | Immunogen Inc. | Anti-IGF-I receptor antibody |
| AU2003280130B2 (en) | 2002-06-28 | 2009-06-11 | Centocor, Inc. | Mammalian CH1 deleted mimetibodies, compositions, methods and uses |
| JP2005536992A (ja) | 2002-06-28 | 2005-12-08 | セントカー・インコーポレーテツド | 哺乳動物のepo模倣ch1欠失ミメティボディ、組成物、方法および使用 |
| US7338465B2 (en) | 2002-07-02 | 2008-03-04 | Patton Medical Devices, Lp | Infusion device and method thereof |
| US20040010207A1 (en) | 2002-07-15 | 2004-01-15 | Flaherty J. Christopher | Self-contained, automatic transcutaneous physiologic sensing system |
| WO2004009627A1 (en) | 2002-07-19 | 2004-01-29 | Cangene Corporation | Pegylated erythropoietic compounds |
| ES2720098T3 (es) | 2002-07-22 | 2019-07-17 | Becton Dickinson Co | Dispositivo de infusión similar a un parche |
| US6811547B2 (en) | 2002-07-22 | 2004-11-02 | Becton, Dickinson & Company | Needle shielding assembly |
| TW200413406A (en) | 2002-08-26 | 2004-08-01 | Kirin Brewery | Peptides and drugs containing the same |
| CA2824167C (en) | 2002-09-06 | 2018-09-25 | Amgen Inc. | Therapeutic human anti-il-1r1 monoclonal antibody |
| WO2005025606A1 (en) | 2003-09-09 | 2005-03-24 | Warren Pharmaceuticals, Inc. | Long acting erythropoietins that maintain tissue protective activity of endogenous erythropoietin |
| BR0314106A (pt) | 2002-09-11 | 2005-07-19 | Fresenius Kabi De Gmbh | Polipeptìdeos hasilados, especialmente eritropoietina hasilada |
| US6919426B2 (en) | 2002-09-19 | 2005-07-19 | Amgen Inc. | Peptides and related molecules that modulate nerve growth factor activity |
| US7169132B2 (en) | 2002-10-01 | 2007-01-30 | Becton, Dickinson And Company | Medication delivery pen |
| US7396913B2 (en) | 2002-10-14 | 2008-07-08 | Abbott Laboratories | Erythropoietin receptor binding antibodies |
| US20040071694A1 (en) | 2002-10-14 | 2004-04-15 | Devries Peter J. | Erythropoietin receptor binding antibodies |
| TWI320716B (en) | 2002-10-14 | 2010-02-21 | Abbott Lab | Erythropoietin receptor binding antibodies |
| AU2003285874A1 (en) | 2002-10-16 | 2004-05-04 | Amgen Inc. | HUMAN ANTI-IFN-Gamma NEUTRALIZING ANTIBODIES AS SELECTIVE IFN-Gamma PATHWAY INHIBITORS |
| US6883222B2 (en) | 2002-10-16 | 2005-04-26 | Bioject Inc. | Drug cartridge assembly and method of manufacture |
| US20040091961A1 (en) | 2002-11-08 | 2004-05-13 | Evans Glen A. | Enhanced variants of erythropoietin and methods of use |
| CN101287484B (zh) | 2002-12-20 | 2012-10-10 | 安姆根有限公司 | 抑制肌肉生长抑制素的结合剂 |
| US7252651B2 (en) | 2003-01-07 | 2007-08-07 | Becton, Dickinson And Company | Disposable injection device |
| WO2004083248A1 (en) | 2003-03-14 | 2004-09-30 | Pharmacia Corporation | Antibodies to igf-i receptor for the treatment of cancers |
| CL2004000581A1 (es) | 2003-03-20 | 2005-01-21 | Unitract Syringe Pty Ltd | Reten de resorte para jeringa formado por un primer y segundo elemento ubicados en el extremo proximal de la jeringa, adaptados para comprimir un resorte, al liberarse el resorte actua sobre el embolo y retrae la aguja al interior de la jeringa lo qu |
| EP1613658B1 (en) | 2003-04-02 | 2012-03-14 | F. Hoffmann-La Roche AG | Antibodies against insulin-like growth factor i receptor and uses thereof |
| JP2004305621A (ja) | 2003-04-10 | 2004-11-04 | Jms Co Ltd | 針アダプタ |
| US7220410B2 (en) | 2003-04-18 | 2007-05-22 | Galaxy Biotech, Llc | Monoclonal antibodies to hepatocyte growth factor |
| US7963956B2 (en) | 2003-04-22 | 2011-06-21 | Antisense Pharma Gmbh | Portable equipment for administration of fluids into tissues and tumors by convection enhanced delivery technique |
| EP1631496B1 (en) | 2003-04-28 | 2014-02-26 | Medical Instill Technologies, Inc. | Container with valve assembly for filling and dispensing substances, and apparatus and method for filling |
| WO2005016970A2 (en) | 2003-05-01 | 2005-02-24 | Imclone Systems Incorporated | Fully human antibodies directed against the human insulin-like growth factor-1 receptor |
| TWI353991B (en) | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
| JP2007530440A (ja) | 2003-05-12 | 2007-11-01 | アフィーマックス・インコーポレイテッド | 新規ポリ(エチレングリコール)修飾化合物およびその用途 |
| JP4266028B2 (ja) | 2003-05-12 | 2009-05-20 | アフィーマックス・インコーポレイテッド | エリスロポエチン受容体に結合する新規ペプチド |
| SI1625156T1 (sl) | 2003-05-12 | 2013-02-28 | Affymax, Inc. | Peptidi, ki se veĹľejo k eritropoetinskemu receptorju |
| US7074755B2 (en) | 2003-05-17 | 2006-07-11 | Centocor, Inc. | Erythropoietin conjugate compounds with extended half-lives |
| KR20060032140A (ko) | 2003-05-30 | 2006-04-14 | 센토코 인코포레이티드 | 트랜스글루타미나아제를 이용한 신규 에리트로포이에틴접합체의 형성 |
| WO2005001136A1 (en) | 2003-06-04 | 2005-01-06 | Irm Llc | Methods and compositions for modulating erythropoietin expression |
| GB0315953D0 (en) | 2003-07-08 | 2003-08-13 | Glaxosmithkline Biolog Sa | Process |
| AR046071A1 (es) | 2003-07-10 | 2005-11-23 | Hoffmann La Roche | Anticuerpos contra el receptor i del factor de crecimiento de tipo insulinico y los usos de los mismos |
| CN102408483B (zh) | 2003-07-15 | 2016-06-08 | 安姆根有限公司 | 作为选择性ngf途径抑制剂的人抗ngf中和抗体 |
| KR101254371B1 (ko) | 2003-07-18 | 2013-05-02 | 암젠 프레몬트 인코포레이티드 | 간세포 성장인자에 결합하는 분리된 항체 |
| US20050019914A1 (en) | 2003-07-24 | 2005-01-27 | Aventis Pharma Deutschland Gmbh | Perfusion process for producing erythropoietin |
| US7220244B2 (en) | 2003-08-04 | 2007-05-22 | Bioquiddity, Inc. | Infusion apparatus with constant force spring energy source |
| US20070275871A1 (en) | 2003-08-28 | 2007-11-29 | Biorexis Technology, Inc. | Epo Mimetic Peptides and Fusion Proteins |
| EP1687452A4 (en) | 2003-09-30 | 2008-08-06 | Centocor Inc | HUMAN HINGE-CORE MIMETICORPS, COMPOSITIONS, METHODS AND APPLICATIONS THEREOF |
| UA89481C2 (uk) | 2003-09-30 | 2010-02-10 | Центокор, Инк. | Еритропоетинові міметичні шарнірно-серцевинні міметитіла людини, композиції, способи та застосування |
| KR20060099520A (ko) | 2003-10-21 | 2006-09-19 | 노보 노르디스크 에이/에스 | 의료용 피부 장착 장치 |
| MXPA06004853A (es) | 2003-11-07 | 2006-07-06 | Immunex Corp | Anticuerpos que se aglutinan al receptor 4 de interleucina. |
| TWM261223U (en) | 2003-11-14 | 2005-04-11 | Life Shueld Products Inc | Retractable safety syringe |
| PE20050928A1 (es) | 2003-11-21 | 2005-11-08 | Schering Corp | Combinaciones terapeuticas de anticuerpo anti-igfr1 |
| US8633157B2 (en) | 2003-11-24 | 2014-01-21 | Novo Nordisk A/S | Glycopegylated erythropoietin |
| ES2445948T3 (es) | 2003-11-24 | 2014-03-06 | Ratiopharm Gmbh | Eritropoyetina glicopegilada |
| WO2005058967A2 (en) | 2003-12-16 | 2005-06-30 | Pierre Fabre Medicament | Novel anti-insulin/igf-i hybrid receptor or anti-insulin/igf-i hybrid receptor and igf-ir antibodies and uses thereof |
| EP1548031A1 (en) | 2003-12-22 | 2005-06-29 | Dubai Genetics FZ-LLC | Nature-identical erythropoietin |
| WO2005065239A2 (en) | 2003-12-31 | 2005-07-21 | Centocor, Inc. | Novel recombinant proteins with n-terminal free thiol |
| JP2008504008A (ja) | 2003-12-31 | 2008-02-14 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | 改良された薬物動態を有するFc−エリスロポエチン融合タンパク質 |
| US7794436B2 (en) | 2004-01-13 | 2010-09-14 | Lloyd Jay Pinel | Controlled gastric bolus feeding device |
| US7423139B2 (en) | 2004-01-20 | 2008-09-09 | Insight Biopharmaceuticals Ltd. | High level expression of recombinant human erythropoietin having a modified 5′-UTR |
| WO2005070451A1 (en) | 2004-01-22 | 2005-08-04 | Zafena Aktiebolag | Pharmaceutical composition comprising non-glycosylated erythropoietin |
| US20050177108A1 (en) | 2004-02-10 | 2005-08-11 | Animas Corporation | External infusion device having a casing with multiple cross-vented hermetically-sealed housings |
| WO2005084711A1 (en) | 2004-03-02 | 2005-09-15 | Chengdu Institute Of Biological Products | A pegylated recombinant erythropoietin that has in vivo activity |
| WO2005092369A2 (en) | 2004-03-11 | 2005-10-06 | Fresenius Kabi Deutschland Gmbh | Conjugates of hydroxyethyl starch and erythropoietin |
| US20050227289A1 (en) | 2004-04-09 | 2005-10-13 | Reilly Edward B | Antibodies to erythropoietin receptor and uses thereof |
| JP2008508854A (ja) | 2004-04-23 | 2008-03-27 | ケンブリッジ アンティボディー テクノロジー リミテッド | エリスロポイエチンタンパク質変異体 |
| US7220245B2 (en) | 2004-05-26 | 2007-05-22 | Kriesel Marshall S | Infusion apparatus |
| US20050277883A1 (en) | 2004-05-26 | 2005-12-15 | Kriesel Marshall S | Fluid delivery device |
| US20050267422A1 (en) | 2004-05-26 | 2005-12-01 | Kriesel Marshall S | Fluid delivery apparatus |
| DE602005014117D1 (de) | 2004-07-07 | 2009-06-04 | Lundbeck As Valby H | Neues carbamyliertes epo und verfahren zu dessen herstellung |
| WO2006007642A1 (en) | 2004-07-16 | 2006-01-26 | Unitract Syringe Pty Ltd | Syringe needle sheath |
| FR2873699B1 (fr) | 2004-07-29 | 2009-08-21 | Pierre Fabre Medicament Sa | Nouveaux anticorps anti igf ir rt leurs utilisations |
| US20060073563A1 (en) | 2004-09-02 | 2006-04-06 | Xencor, Inc. | Erythropoietin derivatives with altered immunogenicity |
| EP1812461A2 (en) | 2004-11-10 | 2007-08-01 | AplaGen GmbH | Molecules which promote hematopoiesis |
| GB0426479D0 (en) | 2004-12-02 | 2005-01-05 | Glaxosmithkline Biolog Sa | Novel device |
| US20060178638A1 (en) | 2004-12-03 | 2006-08-10 | Reynolds David L | Device and method for pharmaceutical mixing and delivery |
| MY146381A (en) | 2004-12-22 | 2012-08-15 | Amgen Inc | Compositions and methods relating relating to anti-igf-1 receptor antibodies |
| CN101312759B (zh) | 2004-12-24 | 2013-04-10 | 科林专利控股有限公司 | 安全注射器 |
| US7906625B2 (en) | 2005-01-24 | 2011-03-15 | Amgen Inc. | Humanized anti-amyloid antibody |
| US8029468B2 (en) | 2005-02-15 | 2011-10-04 | Bioquiddity, Inc. | Fluid delivery and mixing apparatus with flow rate control |
| US20080009835A1 (en) | 2005-02-17 | 2008-01-10 | Kriesel Marshall S | Fluid dispensing apparatus with flow rate control |
| US7837653B2 (en) | 2005-02-18 | 2010-11-23 | Bioquiddity, Inc. | Fluid delivery apparatus with vial fill |
| US7592429B2 (en) | 2005-05-03 | 2009-09-22 | Ucb Sa | Sclerostin-binding antibody |
| US7686787B2 (en) | 2005-05-06 | 2010-03-30 | Medtronic Minimed, Inc. | Infusion device and method with disposable portion |
| US8277415B2 (en) | 2006-08-23 | 2012-10-02 | Medtronic Minimed, Inc. | Infusion medium delivery device and method with drive device for driving plunger in reservoir |
| US7905868B2 (en) | 2006-08-23 | 2011-03-15 | Medtronic Minimed, Inc. | Infusion medium delivery device and method with drive device for driving plunger in reservoir |
| CA2612449A1 (en) | 2005-06-17 | 2006-12-28 | Imclone Systems Incorporated | Receptor antagonists for treatment of metastatic bone cancer |
| WO2007000328A1 (en) | 2005-06-27 | 2007-01-04 | Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa | Antibodies that bind to an epitope on insulin-like growth factor 1 receptor and uses thereof |
| US8603034B2 (en) | 2005-07-12 | 2013-12-10 | Applied Diabetes Research, Inc. | One piece sealing reservoir for an insulin infusion pump |
| AU2006270009A1 (en) | 2005-07-18 | 2007-01-25 | Amgen Inc. | Human anti-B7RP1 neutralizing antibodies |
| FR2888850B1 (fr) | 2005-07-22 | 2013-01-11 | Pf Medicament | Nouveaux anticorps anti-igf-ir et leurs applications |
| DE102005038368A1 (de) | 2005-08-13 | 2007-02-15 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Doppelkammer-Behälter zur Lyophilisation, Verfahren zu dessen Befüllung und dessen Verwendung |
| PE20071101A1 (es) | 2005-08-31 | 2007-12-21 | Amgen Inc | Polipeptidos y anticuerpos |
| JP4150389B2 (ja) | 2005-09-05 | 2008-09-17 | 日本ケミカルリサーチ株式会社 | 注射装置 |
| US8409142B2 (en) | 2005-09-26 | 2013-04-02 | Asante Solutions, Inc. | Operating an infusion pump system |
| EP1933901B1 (en) | 2005-09-26 | 2014-12-31 | Asante Solutions, Inc. | Portable infusion pump having a flexible pushrod with hinged portions |
| US8105279B2 (en) | 2005-09-26 | 2012-01-31 | M2 Group Holdings, Inc. | Dispensing fluid from an infusion pump system |
| ES2567443T3 (es) | 2005-10-13 | 2016-04-22 | Becton Dickinson And Company | Conjunto de conector y aguja desechable |
| JP4943690B2 (ja) | 2005-10-27 | 2012-05-30 | 前田産業株式会社 | シリンジホルダー及び注射器 |
| US20150057615A1 (en) | 2005-11-08 | 2015-02-26 | Asante Solutions | Infusion Pump System |
| US9839743B2 (en) | 2006-02-09 | 2017-12-12 | Deka Products Limited Partnership | Apparatus, system and method for fluid delivery |
| JP2007209675A (ja) * | 2006-02-13 | 2007-08-23 | Chemo Sero Therapeut Res Inst | プレフィルドシリンジの製造方法 |
| ATE406926T1 (de) | 2006-02-14 | 2008-09-15 | Gerresheimer Buende Gmbh | Verfahren zum herstellen von vorfüllbaren spritzen |
| US7828772B2 (en) | 2006-03-15 | 2010-11-09 | Bioquiddity, Inc. | Fluid dispensing device |
| US20080097306A1 (en) | 2006-08-29 | 2008-04-24 | Jeffrey Smith | Sterilized syringe |
| TWI395754B (zh) | 2006-04-24 | 2013-05-11 | Amgen Inc | 人類化之c-kit抗體 |
| MX2008014744A (es) | 2006-05-19 | 2009-02-10 | Glycofi Inc | Composiciones de eritrocpoyetina. |
| TW200743500A (en) | 2006-05-26 | 2007-12-01 | ming-zheng Xu | Disposable syringe |
| US20070282269A1 (en) | 2006-05-31 | 2007-12-06 | Seattle Medical Technologies | Cannula delivery apparatus and method for a disposable infusion device |
| US8292848B2 (en) | 2006-07-31 | 2012-10-23 | Bio Quiddity, Inc. | Fluid dispensing device with additive |
| US7736338B2 (en) | 2006-08-23 | 2010-06-15 | Medtronic Minimed, Inc. | Infusion medium delivery system, device and method with needle inserter and needle inserter device and method |
| CL2007002567A1 (es) | 2006-09-08 | 2008-02-01 | Amgen Inc | Proteinas aisladas de enlace a activina a humana. |
| US8337483B2 (en) | 2006-11-02 | 2012-12-25 | Becton, Dickinson And Company | Vascular access device chamber replacement |
| CA2667894A1 (en) | 2006-11-07 | 2008-05-15 | Merck & Co., Inc. | Antagonists of pcsk9 |
| US20100040611A1 (en) | 2006-11-07 | 2010-02-18 | Sparrow Carl P | Antagonists of pcsk9 |
| WO2008057458A2 (en) | 2006-11-07 | 2008-05-15 | Merck & Co., Inc. | Antagonists of pcsk9 |
| WO2008133647A2 (en) | 2006-11-07 | 2008-11-06 | Merck & Co., Inc. | Antagonists of pcsk9 |
| US7938801B2 (en) | 2006-11-22 | 2011-05-10 | Calibra Medical, Inc. | Disposable infusion device filling apparatus and method |
| WO2008067467A2 (en) | 2006-11-29 | 2008-06-05 | West Pharmaceutical Services, Inc. | Syringe cartridge system |
| ATE432726T1 (de) | 2006-11-29 | 2009-06-15 | Ming-Jeng Shue | Einwegspritze mit eingebauter karpulle |
| US20080154243A1 (en) | 2006-12-20 | 2008-06-26 | Beta Micropump Partners Llc | Delivery device for a fluid |
| FI3632488T3 (fi) | 2006-12-22 | 2023-05-25 | Roche Diabetes Care Gmbh | Laite terapeuttisen nesteen pitkäaikaiseen jakeluun |
| EP2104525A4 (en) | 2006-12-29 | 2010-12-29 | Amir Genosar | HYPODERMIC RESERVOIR AND APPARATUS FOR DRUG DELIVERY |
| WO2008092782A1 (en) | 2007-02-02 | 2008-08-07 | Unomedical A/S | Injection site for injecting medication |
| US8251960B2 (en) | 2007-03-24 | 2012-08-28 | The Alfred E. Mann Foundation For Scientific Research | Valves, valved fluid transfer devices and ambulatory infusion devices including the same |
| US20080243084A1 (en) | 2007-03-30 | 2008-10-02 | Animas Corporation | User-releasable side-attach rotary infusion set |
| US20080249505A1 (en) | 2007-03-30 | 2008-10-09 | Animas Corporation | Method for mounting an infusion set with user-controlled 360-degree rotary motion hub to an infusion site |
| CN101679527A (zh) | 2007-04-13 | 2010-03-24 | 诺瓦提斯公司 | 用于调节前蛋白转化酶枯草杆菌蛋白酶/kexin9型(pcsk9)的分子和方法 |
| WO2008136845A2 (en) | 2007-04-30 | 2008-11-13 | Medtronic Minimed, Inc. | Reservoir filling, bubble management, and infusion medium delivery systems and methods with same |
| US7794426B2 (en) | 2007-05-21 | 2010-09-14 | Asante Solutions, Inc. | Infusion pump system with contamination-resistant features |
| US8211059B2 (en) | 2007-06-25 | 2012-07-03 | Kriesel Marshall S | Fluid dispenser with additive sub-system |
| US20080319385A1 (en) | 2007-06-25 | 2008-12-25 | Kriesel Marshall S | Fluid dispenser with additive sub-system |
| US8226609B2 (en) | 2007-06-25 | 2012-07-24 | Bioquiddity, Inc. | Fluid dispenser with additive sub-system |
| EP2178583B1 (en) | 2007-07-20 | 2014-02-12 | Medingo Ltd. | Vented dispensing device |
| DE102007034871A1 (de) | 2007-07-24 | 2009-01-29 | Lts Lohmann Therapie-Systeme Ag | Einweginjektor mit handbetätigbarem Kolben |
| JOP20080381B1 (ar) | 2007-08-23 | 2023-03-28 | Amgen Inc | بروتينات مرتبطة بمولدات مضادات تتفاعل مع بروبروتين كونفيرتاز سيتيليزين ككسين من النوع 9 (pcsk9) |
| WO2009029572A1 (en) | 2007-08-24 | 2009-03-05 | Deka Products Limited Partnership | Microneedle systems and apparatus |
| WO2009029010A1 (en) | 2007-08-30 | 2009-03-05 | Carmel Pharma Ab | Device, sealing member and fluid container |
| CA2698103A1 (en) | 2007-08-31 | 2009-03-05 | Amgen Inc. | Solid-state protein formulation |
| US7717903B2 (en) | 2007-09-06 | 2010-05-18 | M2 Group Holdings, Inc. | Operating an infusion pump system |
| US7879026B2 (en) | 2007-09-07 | 2011-02-01 | Asante Solutions, Inc. | Controlled adjustment of medicine dispensation from an infusion pump device |
| US7935105B2 (en) | 2007-09-07 | 2011-05-03 | Asante Solutions, Inc. | Data storage for an infusion pump system |
| EP2205639B1 (en) | 2007-10-26 | 2015-12-23 | Merck Sharp & Dohme Corp. | Anti-pcsk9 and methods for treating lipid and cholesterol disorders |
| US10188787B2 (en) | 2007-12-31 | 2019-01-29 | Deka Products Limited Partnership | Apparatus, system and method for fluid delivery |
| US8491570B2 (en) | 2007-12-31 | 2013-07-23 | Deka Products Limited Partnership | Infusion pump assembly |
| EP2359880A3 (en) | 2008-02-04 | 2011-09-21 | Nilimedix Ltd. | Drug delivery system with wireless monitor |
| AR070315A1 (es) | 2008-02-07 | 2010-03-31 | Merck & Co Inc | Anticuerpos 1b20 antagonistas de pcsk9 |
| AR070316A1 (es) | 2008-02-07 | 2010-03-31 | Merck & Co Inc | Antagonistas de pcsk9 (proproteina subtilisina-kexina tipo 9) |
| WO2009103199A1 (zh) | 2008-02-18 | 2009-08-27 | 江苏恒瑞医药股份有限公司 | 水溶性聚合物修饰的g-csf偶联物 |
| JP2009207619A (ja) | 2008-03-03 | 2009-09-17 | Terumo Corp | 医療用容器 |
| WO2010061234A1 (en) | 2008-04-01 | 2010-06-03 | Gambro Lundia Ab | A medical connector |
| US8597269B2 (en) | 2008-04-11 | 2013-12-03 | Medtronic Minimed, Inc. | Reservoir seal retainer systems and methods |
| CA2873003C (en) | 2008-05-14 | 2017-06-13 | J&J Solutions, Inc. | Systems and methods for safe medicament transport |
| EP2326365B1 (en) | 2008-08-18 | 2020-01-01 | Calibra Medical LLC | Drug infusion system with reusable and disposable components |
| US7772006B2 (en) | 2008-08-21 | 2010-08-10 | Paul Tornambe | Agent detection and/or quantitation in a biological fluid |
| EP2346551B1 (en) | 2008-08-30 | 2020-12-16 | Sanofi-Aventis Deutschland GmbH | Cartridge and needle system therefor |
| MX2011002182A (es) * | 2008-09-10 | 2011-03-30 | Hoffmann La Roche | Dispositivo de liberacion para usarse con un farmaco terapeutico. |
| EP2361107B1 (en) | 2008-09-10 | 2019-02-20 | Thomasevans, Llc | Multi-chambered mixing syringe device and methods of use |
| TWI516501B (zh) | 2008-09-12 | 2016-01-11 | 禮納特神經系統科學公司 | Pcsk9拮抗劑類 |
| US8728024B2 (en) | 2008-10-10 | 2014-05-20 | Deka Products Limited Partnership | Infusion pump methods, systems and apparatus |
| AU2009322474A1 (en) | 2008-12-01 | 2011-07-21 | Lifespan Extension Llc | Methods and compositions for altering health, wellbeing, and lifespan |
| JO3672B1 (ar) | 2008-12-15 | 2020-08-27 | Regeneron Pharma | أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9). |
| US9370621B2 (en) | 2008-12-16 | 2016-06-21 | Medtronic Minimed, Inc. | Needle insertion systems and methods |
| EP2201976A1 (en) | 2008-12-23 | 2010-06-30 | Sanofi-Aventis Deutschland GmbH | Apparatus for holding a cover of a needle unit and method |
| US9375529B2 (en) | 2009-09-02 | 2016-06-28 | Becton, Dickinson And Company | Extended use medical device |
| EP2601934A1 (en) | 2009-01-22 | 2013-06-12 | Ludwig-Maximilians-Universität München | Vesicular phospholipid gels comprising proteinaceous substances |
| US9125981B2 (en) | 2009-02-21 | 2015-09-08 | Incumed, Llc | Fluid cartridges including a power source and partially implantable medical devices for use with same |
| US9370619B2 (en) | 2009-02-21 | 2016-06-21 | Incumed, Llc | Partially implantable medical devices and delivery/manifold tube for use with same |
| US20100249753A1 (en) | 2009-02-25 | 2010-09-30 | Gaisser David M | Vented syringe system and method for the containment, mixing and ejection of wetted particulate material |
| WO2010098323A1 (ja) | 2009-02-25 | 2010-09-02 | テルモ株式会社 | プレフィルドシリンジの製造方法およびプレフィルドシリンジ |
| US8597256B2 (en) | 2009-03-06 | 2013-12-03 | Sanofi-Aventis Deutschland Gmbh | Seal member |
| US8894608B2 (en) | 2009-05-22 | 2014-11-25 | Michael P. Connair | Steroid delivery system |
| AR076716A1 (es) | 2009-06-02 | 2011-06-29 | Sanofi Aventis Deutschland | Modulo medicado con medicamento de premezcla |
| AR076719A1 (es) * | 2009-06-02 | 2011-06-29 | Sanofi Aventis Deutschland | Modulo medicinal con derivacion y protector de aguja |
| TW201100135A (en) | 2009-06-19 | 2011-01-01 | Addino B V | Hypodermic syringe with retractable needle |
| GB2471304B (en) | 2009-06-24 | 2013-12-11 | Oval Medical Technologies Ltd | A pre-filled syringe or autoinjector |
| US9179710B2 (en) | 2009-06-30 | 2015-11-10 | Inhale, Inc. | Hookah with multiple tobacco bowls |
| GB2471726B (en) | 2009-07-10 | 2013-09-11 | Oval Medical Technologies Ltd | A pre-filled syringe including an oxygen absorber |
| US8401585B2 (en) | 2009-09-03 | 2013-03-19 | Telefonaktiebolaget L M Ericsson (Publ) | Method and apparatus for uplink power control in a wireless communication network |
| WO2011032011A1 (en) | 2009-09-10 | 2011-03-17 | Medipacs, Inc. | Low profile actuator and improved method of caregiver controlled administration of therapeutics |
| US20120219558A1 (en) | 2009-09-25 | 2012-08-30 | Yan Ni | Antagonists of pcsk9 |
| CA2777146A1 (en) | 2009-10-16 | 2011-04-21 | Sanofi-Aventis Deutschland Gmbh | Arrangement for use in a drug delivery device |
| MX344382B (es) | 2009-10-23 | 2016-12-14 | Amgen Inc * | Adaptador de vial y sistema. |
| WO2011053783A2 (en) | 2009-10-30 | 2011-05-05 | Merck Sharp & Dohme Corp. | Ax213 and ax132 pcsk9 antagonists and variants |
| CN102596249A (zh) | 2009-10-30 | 2012-07-18 | 默沙东公司 | Ax1和ax189 pcsk9拮抗剂和变体 |
| WO2011054755A1 (de) | 2009-11-03 | 2011-05-12 | F. Hoffmann-La Roche Ag | Vorrichtung zur keimarmen verabreichung eines fluiden mediums |
| US8449504B2 (en) | 2009-11-11 | 2013-05-28 | Calibra Medical, Inc. | Wearable infusion device and system |
| AR079336A1 (es) | 2009-12-11 | 2012-01-18 | Irm Llc | Antagonistas de la pro-proteina convertasa-subtilisina/quexina tipo 9 (pcsk9) |
| US20110160696A1 (en) | 2009-12-31 | 2011-06-30 | Abbott Diabetes Care Inc. | Injection port device adapted for use with insulin pump |
| CA2786258C (en) | 2009-12-31 | 2018-10-23 | Deka Products Limited Partnership | Infusion pump assembly |
| US20120179109A1 (en) | 2010-03-05 | 2012-07-12 | Masafumi Takemoto | Medical device |
| SG183867A1 (en) | 2010-03-11 | 2012-10-30 | Rinat Neuroscience Corp | ANTIBODIES WITH pH DEPENDENT ANTIGEN BINDING |
| WO2011117287A1 (en) | 2010-03-25 | 2011-09-29 | Sanofi-Aventis Deutschland Gmbh | Medicated module with automatic reservoir engagement |
| JPWO2011122395A1 (ja) | 2010-03-31 | 2013-07-08 | テルモ株式会社 | プレフィルドシリンジ |
| EP2371408B1 (en) | 2010-03-31 | 2013-07-31 | Roche Diagnostics GmbH | Liquid drug degasing devise and ambulatory infusion system including a degasing device |
| EP3360596A1 (en) | 2010-04-21 | 2018-08-15 | AbbVie Biotechnology Ltd. | Wearable automatic injection device for controlled delivery of therapeutic agents |
| US8821454B2 (en) | 2010-05-12 | 2014-09-02 | Bioquiddity, Inc. | Apparatus for dispensing medicinal fluids and method of making same |
| WO2011156373A1 (en) | 2010-06-07 | 2011-12-15 | Amgen Inc. | Drug delivery device |
| WO2012025639A1 (en) | 2010-08-27 | 2012-03-01 | Novo Nordisk A/S | Medical injection device |
| EP2620172A1 (en) | 2010-09-24 | 2013-07-31 | Terumo Kabushiki Kaisha | Method of assembling medicament injection device |
| US8142398B1 (en) | 2010-10-12 | 2012-03-27 | Bioquiddity, Inc. | Fluid dispenser |
| BR112013008882A2 (pt) | 2010-10-13 | 2017-07-11 | Sanofi Aventis Deutschland | mecanismo de definição de dose para um dispositivo de administração de fármaco e método de administração de pelo menos uma dose |
| CA2812355C (en) | 2010-10-18 | 2015-12-29 | Blue Infusion Technologies, Llc | Electronic control glove |
| WO2012054438A1 (en) | 2010-10-22 | 2012-04-26 | Schering Corporation | Anti-pcsk9 |
| CN103282068B (zh) | 2010-11-03 | 2015-06-10 | 赛诺菲-安万特德国有限公司 | 用于防止药剂泄漏的方法和系统 |
| WO2012068432A1 (en) | 2010-11-19 | 2012-05-24 | Msd Consumer Care, Inc. | Click pen applicator device and method of using same |
| KR20130118925A (ko) | 2010-12-22 | 2013-10-30 | 제넨테크, 인크. | 항-pcsk9 항체 및 사용 방법 |
| US20120191074A1 (en) | 2011-01-21 | 2012-07-26 | Palyon Medical (Bvi) Limited | Reduced sized programmable pump |
| PL3395836T3 (pl) | 2011-01-28 | 2021-12-13 | Sanofi Biotechnology | Ludzkie przeciwciała przeciwko pcsk9 do zastosowania w sposobach leczenia konkretnych grup osobników |
| CN203935494U (zh) | 2011-02-09 | 2014-11-12 | 贝克顿·迪金森公司 | 用于注入套具和注入泵的设备 |
| CN203915611U (zh) | 2011-02-09 | 2014-11-05 | 贝克顿·迪金森公司 | 与输注基部附接的套节及用于传送药物的传送系统 |
| AU2012214251A1 (en) | 2011-02-11 | 2013-09-12 | Novartis Ag | PCSK9 antagonists |
| US20120215183A1 (en) | 2011-02-22 | 2012-08-23 | Medtronic Minimed, Inc. | Fluid infusion device having a sealing assembly for a fluid reservoir |
| US9339639B2 (en) | 2011-02-22 | 2016-05-17 | Medtronic Minimed, Inc. | Sealing assembly for a fluid reservoir of a fluid infusion device |
| CA2831100C (en) | 2011-03-31 | 2020-02-18 | Mark Dominis Holt | Vial adapter and system |
| WO2012145752A2 (en) | 2011-04-21 | 2012-10-26 | Abbott Laboratories | Wearable automatic injection device for controlled administration of therapeutic agents |
| US8795231B2 (en) | 2011-05-10 | 2014-08-05 | Medtronic Minimed, Inc. | Automated reservoir fill system |
| MX339740B (es) | 2011-05-18 | 2016-06-07 | Becton Dickinson Co | Dispositivo para inyeccion. |
| JP6088499B2 (ja) | 2011-06-23 | 2017-03-01 | デバイオテック・ソシエテ・アノニム | Memsマイクロポンプの機能不全検出のための方法及びシステム |
| WO2013016376A2 (en) | 2011-07-25 | 2013-01-31 | Preciflex Sa | Fluid dispenser |
| CN103732274B (zh) | 2011-08-05 | 2017-07-21 | 尤尼特拉克特注射器公司 | 用于注射器的双腔混合装置 |
| KR101541662B1 (ko) | 2011-08-26 | 2015-08-03 | 일라이 릴리 앤드 캄파니 | 주사 장치용 재충전 모듈 |
| US20150258273A1 (en) | 2011-08-31 | 2015-09-17 | Forrest W. Payne | Electrochemically-Actuated Microfluidic Devices |
| US9821118B2 (en) | 2011-09-02 | 2017-11-21 | Unl Holdings Llc | Automatic reconstitution for dual chamber syringe |
| CA2847711C (en) | 2011-09-07 | 2019-08-20 | 3M Innovative Properties Company | Delivery system for hollow microneedle arrays |
| ES2675035T3 (es) | 2011-10-14 | 2018-07-05 | Amgen, Inc | Inyector y método de ensamblaje |
| CN103127579B (zh) | 2011-11-21 | 2017-06-16 | 上海泽生科技开发股份有限公司 | 便携式注射泵的驱动系统 |
| WO2013089105A1 (ja) | 2011-12-15 | 2013-06-20 | テルモ株式会社 | プレフィルドシリンジ用筒状体、プレフィルドシリンジ用穿刺具、プレフィルドシリンジ用注射器およびプレフィルドシリンジ |
| US10052435B2 (en) | 2012-01-31 | 2018-08-21 | Precifiex SA | Skin-attachable miniature drug injection device with remote activation capability and dry drug carrier within injection needle |
| DK2819724T3 (da) | 2012-02-27 | 2019-05-27 | Hoffmann La Roche | Fjederkraftsamling til forspænding eller aktivering af propper i sprøjter, patroner til injektionspenne og lignende |
| CN104470559B (zh) * | 2012-03-12 | 2018-02-06 | 尤尼特拉克特注射器控股有限公司 | 用于无菌流体路径组件的填充匣及包含填充匣的药物输送装置 |
| US9155866B2 (en) | 2012-09-13 | 2015-10-13 | Becton, Dickinson And Company | Luer securement device |
| US9463280B2 (en) | 2012-03-26 | 2016-10-11 | Medimop Medical Projects Ltd. | Motion activated septum puncturing drug delivery device |
| US10780228B2 (en) * | 2012-05-07 | 2020-09-22 | Medline Industries, Inc. | Prefilled container systems |
| CN202723859U (zh) | 2012-06-28 | 2013-02-13 | 河南曙光健士医疗器械集团股份有限公司 | 安全采血器 |
| CA2878716C (en) | 2012-07-11 | 2021-05-04 | Unitract Syringe Pty Ltd | Insertion mechanisms having vented fluid pathways for drug delivery pumps |
| US8454562B1 (en) | 2012-07-20 | 2013-06-04 | Asante Solutions, Inc. | Infusion pump system and method |
| CN104684597A (zh) | 2012-08-20 | 2015-06-03 | 霍夫曼-拉罗奇有限公司 | 带有用于输液器的适配器的治疗系统 |
| EP2712651A1 (en) | 2012-09-27 | 2014-04-02 | F. Hoffmann-La Roche AG | Venting device for use in ambulatory infusion system |
| JP2016500013A (ja) | 2012-10-16 | 2016-01-07 | スイスイノヴ プロダクト サールSwissinnov Product Sarl | 流体供給システムおよび方法 |
| JP2014087449A (ja) | 2012-10-30 | 2014-05-15 | Seiko Epson Corp | 液体輸送装置及びカテーテルの抜け判定方法 |
| EP2948206B1 (en) | 2013-01-25 | 2020-10-14 | UNL Holdings LLC | Integrated sliding seal fluid pathway connection and drug containers for drug delivery pumps |
| US10080839B2 (en) | 2013-03-14 | 2018-09-25 | Becton, Dickinson And Company | Angled inserter for drug infusion |
| US9821113B2 (en) | 2013-03-15 | 2017-11-21 | Becton, Dickinson And Company | Automatic angled infusion set assembly |
| IL292270B2 (en) | 2013-03-22 | 2024-04-01 | Amgen Inc | Injector and method of assembly |
| US20140323989A1 (en) | 2013-04-24 | 2014-10-30 | Calibra Medical, Inc. | Wearable infusion device with low profile handle |
| DK2815778T3 (da) | 2013-06-21 | 2017-11-20 | Hoffmann La Roche | Bærbar infusionsindretning til børn med genopfyldelig doseringsenhed med lille volumen |
| US9737655B2 (en) | 2013-08-23 | 2017-08-22 | Unitract Syringe Pty Ltd | Integrated pierceable seal fluid pathway connection and drug containers for drug delivery pumps |
| US9375537B2 (en) | 2013-10-14 | 2016-06-28 | Medtronic Minimed, Inc. | Therapeutic agent injection device |
| MX373358B (es) * | 2013-10-24 | 2020-07-06 | Amgen Inc | Inyector y método de montaje. |
| US9463889B2 (en) | 2013-10-25 | 2016-10-11 | Medtronic, Inc. | Prefilled reservoir apparatus for ambulatory infusion device |
-
2014
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- 2014-02-21 EP EP14708447.9A patent/EP2976117B1/en active Active
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- 2014-02-21 WO PCT/US2014/017641 patent/WO2014149357A1/en not_active Ceased
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