US3757779A - Filter syringe - Google Patents

Filter syringe Download PDF

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Publication number
US3757779A
US3757779A US3757779DA US3757779A US 3757779 A US3757779 A US 3757779A US 3757779D A US3757779D A US 3757779DA US 3757779 A US3757779 A US 3757779A
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United States
Prior art keywords
diaphragm
vial
needle
end
liquid
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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W Rovinski
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CENTURY LABOR Inc
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CENTURY LABOR Inc
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Publication of US3757779A publication Critical patent/US3757779A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/28Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/285Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened
    • A61M5/288Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened by piercing without internal pressure increase
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/28Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/284Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle comprising means for injection of two or more media, e.g. by mixing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/32Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3202Devices for protection of the needle before use, e.g. caps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31596Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing
    • A61M2005/31598Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing having multiple telescopically sliding coaxial pistons encompassing volumes for components to be mixed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/3145Filters incorporated in syringes

Abstract

A syringe for the injection of liquid having a diaphragm sealing the open end thereof and a filter member between the diaphragm and the open end of the vial with a hollow needle mounted for reciprocal movement between retracted position beyond the diaphragm and operated position piercing the diaphragm but not piercing the filter member.

Description

United States Patent 11 1 Rovinski 1 51 Sept. 11, 1973 [54] FILTER SYRINGE 2,807,288 9/1957 Shea 128/272 X 2,628,615 2/1953 Saffir 128/272 x [75] Inventor: Walter M. Rv1nsk1,Turnersv1lle, 1,943,120 1934 Kabnick 128mg M 3,557,787 1/1971 Cohen 128/218 M [73] Assignee: Century Laboratories, Inc., Metairie,

La. Primary Examiner-Richard A. Gaudet Assistant Examiner-J. C. McGowan [22] Flled' May 1971 Attorney McDougall, Hersh & Scott [21] Appl. No.: 146,271

, [57] ABSTRACT [52] U.S. Cl. 128/218 M, 128/220 51 1m. (:1 A6lm /00 A Syrmge for the miectlon of llqwd havmg a dlavhragm 58 Field of Search 128/218 M, 272, 21s 1), Sealing the p end thereof and a filter member zg z g NV, 13 R 21 2 2 tween the diaphragm and the open end of the vial with a hollow needle mounted for reciprocal movement be- 5 References Cited tween retracted position beyond the diaphragm and op- UNITED STATES PATENTS erated position piercing the diaphragm but not piercing 1 the tilt mb 3,682,315 8/1972 Haller 128/272 X er me er 2,778,360 1 1/1957 Miskel 128/218 D 1 Claim, 2 Drawing Figures 3,592,245 7/1971 Schneller et a1. 128/272 2,854,977 10/1958 McConnaughey 128/272 3,255,752 6/1966 Dick 128/218 M .AJ: r 2 is x 35 30 3/ 1 1 2'7 1 l i 2 g I \l a9 1 FILTER SYRINGE This invention relates to syringes for the injection of solutions and it relates more particularly to a syringe in which the solutions are effected therein immediately prior to injection by bringing the liquid solvent into contact with the solute in liquid, solid or powdered form.

In the recently issued Cohen US. Pat. No. 3,557,787, description is made of a disposable syringe formed by telescoping tubular members in which the inner tubular member of smaller dimension is adapted to contain a liquid solvent and the outer tubular member of larger dimension is adapted to contain the liquid, powdered or solid material in measured amounts for solution to provide a desired dosage.

The inner tubular member is provided with a flexible seal to separate the two chambers and which is adapted to open in response to pressure generated by a piston member displaceable in the inner tubular member to effect transmission of the liquid from the inner tubular member to the outer tubular member. The end of the inner tubular member sealably engages the inner wall of the outer tubular member and functions as a piston to force displacement of the solution from the outer tubular member into the needle in communication therewith for injection.

It has been found that often times complete solution of the powdered or solid material is not effected with the result that solids remain suspended thereby to represent a foreign material in the solution which it is undesirable to include with the liquid injected.

Similarly, in syringes that have been pre-packaged and sterilized with a solution or liquid to be injected from a single container, often times solids form by reason of decomposition, reaction or otherwise upon standing thereby to represent a foreign material which it is undesirable to include with the solution or liquid that is being injected.

Thus it is an object of this invention to provide a syringe for the injection of liquid or other solution and which embodies means for the removal of solids contained or otherwise suspended therein as the liquid is being ejected from the syringe.

These and other objects and advantages of this invention will hereinafter appear and for purposes of illustration, but not of limitation, an embodiment of the invention is shown in the accompanying drawing in which:

FIG. 1 is a schematic sectional elevational view of a sryinge embodying the features of this invention in normal position of use; and

FIG. 2 is a sectional elevational view showing the arrangement of elements during ejection of fluid from the needle end portion of the syringe.

Referring now to the drawing, the fluid to be injected is illustrated as being contained in a vial l2 having an open end 14 formed with a neck portion 16 which terminates in an outwardly extending angular flange portion 18. The fluid 10 is maintained in sealing relation within the vial by means of a diaphragm of rubber or plastic material which is dimensioned to span the opening and extend therebeyond for a distance corresponding to the neck flange 18 of the vial. The diaphragm 20 is clamped in sealing relation on the end of the vial by means of a metal cup 22 which is crimped about the outer flange portion of the neck and the corresponding outer edge portions of the diaphragm 20 to effect a sealing engagement between the adjacent flattened outer end portion of the neck flange l8 and the diaphragm 20, when in the assembled relation. The cup member 22 is formed at its outer end with an inwardly extending annular flange 25 and compressed within said cup resiliently to engage the annular flange is a compression spring 26 which is wound about a needle hub 27having a disc member 31 of larger dimension which functions as an abutment for the opposite end of the spring. The main outward portion of the hub is formed with threads 29 for threaded engagement with internal threads of a needle cover 32.

The hub member supports a hollow needle 28 which is mounted for endwise movement between a retracted position in which the inner sharpened end portion 30 terminates just short of the diaphragm 20 and an operated position in which the needle is displaced inwardly to a position wherein the inner sharpened end portion 30 of the needle penetrates the diaphragm for direct communication with the interior of the vial to enable ejection of fluid from the vial through the needle. Reference may be made to U. S. Pat. Nos. 3,557,787 and No. 3,401,693 for means for mounting the needle releasably to retain the needle in retracted position for releasing for movement to operated position in response to removal of the needle cover 32. in the modification illustrated in FIG. 1, the coil springs 26 operate immediately to effect displacement of the needle from retracted to operated position in response to removal of the needle cover which releases the hub.

In accordance with the practice of this invention, direct communication between the needle and the interior of the vial containing the liquid to be ejected is obstructed by a filter member 34 in the form of a filter disc which extends crosswise between the flanged open end portion of the vial and the diaphragm to span the open end of the vial and for sealing engagement between the clamped flanged neck end portion 18 of the vial and the diaphragm 20, as by heat sealing to the upper surface of the diaphragm. The filter disc can be formedof ceramic, paper, plastic, rubber, glass or the like material having communicating fine pores for the removal of solids from the liquid passing therethrough but without obstructing fluid flow, such as filter pores of 0.1 to 1 micron and preferably about 0.2 to 0.4 micron.

In order to permit needle penetration of the diaphragm 20 without piercing the filter disc 34, the diaphragm is dimensioned to have a thickness whereby the inner wall 36 is spaced inwardly from the end 30 of the needle when the latter is in operated position. A well 38 is provided to extend through the central portion of the diaphragm from the inner wall in endwise alignment with the needle to a depth sufficient to provide for entrance of the needle end 30 when displaced to operated position. Thus, the diaphragm 20 is effective to maintain the sealed relationship to seal the liquid in the vial while enabling penetration of the needle into the well for communication with the interior of the vial when in operated position. The filter element 34is in position beyond the end of the needle to separate the well from the interior of the vial whereby all liquid entering the well for ejection through the needle is required to pass through the filter element.

Operation of the invention will be described with reference to a syringe of the type illustrated in U. S. Pat. No. 3,557,787, although it will be understood that the inventive concepts may be adapted to a syringe in which the liquid to be injected is housed within a single vial having a piston member adapted to force the liquid from the vial.

In the modification which is shown in FIG. 1, when it is desired to effect injection of a measured amount of liquid from the syringe, the piston 44 in the inner vial 42 is displaced endwise to force the liquid 40 for displacement through the flexible sealing diaphragm 46 from the inner vial to the outer vial 12 containing the powder 48. The vials are then shaken to dissolve the powder or other solid material or to mix the two different liquids in the event that one vial contains one and the another the other. When the solution has been effected and the injection is to be made, the needle cover 32 is removed. This releases the needle 28 which is actuated by the tension springs 50 for displacement from retracted to operated position during which the end 30 of the needle pierces the thin wall of the diaphragm for entrance of the needle into the well 38.

Thereafter, the inner vial 42 is displaced in the illustrated modification to eject the liquid from the outer vial 12. This forces the liquid to flow through the filter element 34 to fill the well 38 and from the well to the needle 28 for injection as pressure continues to be placed on the liquid in the vial. Solids 52, which remain suspended in the liquid, are separated out on the ingoing side of the filter surface as the liquid flows therethrough thereby to deliver a filtered fluid to the needle 28.

It will be understood that the concepts of this invention will have application to syringe devices formed of but a single vial in which a liquid material is contained for injection with the filter element and diaphragm arranged in the manner heretofore described.

It will be understood that changes may be made in the open end of the vial in sealing relation therewith,

a hollow injection needle having inner and outer pointed ends endwise aligned with the open end of the vial and mounted for endwise movement between retracted position with the inner end of the needle spaced a short distance beyond the diaphragm and operated position with the inner end of the needle piercing the diaphragm, the improvement which comprises a filter member spanning the open end of the vial between the end of the vial and the diaphragm, said diaphragm constituting a member separate and apart from the filter, a well in the diaphragm extending from the side adjacent the filter member partially through the diaphragm in endwise alignment with the needle and into which the inner end of the needle extends when in operated position and stop means mounted intermediate the needle ends, whereby in the operated position the inner needle end will extend through the diaphragm but not pierce the filter.

Claims (1)

1. In a syringe for the injection of a liquid including a vial having an open end through which the liquid is to be ejected from the vial and a plunger axially displaceable in said vial for displacement of liquid through the open end, a rupturable diaphragm extending across the open end of the vial in sealing relation therewith, a hollow injection needle having inner and outer pointed ends endwise aligned with the open end of the vial and mounted for endwise movement between retracted position with the inner end of the needle spaced a short distance beyond the diaphragm and operated position with the inner end of the needle piercing the diaphragm, the improvement which comprises a filter member spanning the open end of the vial between the end of the vial and the diaphragm, said diaphragm constituting a member separate and apart from the filter, a well in the diaphragm extending from the side adjacent the filter member partially through the diaphragm in endwise alignment with the needle and into which the inner end of the needle extends when in operated position and stop means mounted intermediate the needle ends, whereby in the operated position the inner needle end will extend through the diaphragm but not pierce the filter.
US3757779D 1971-05-24 1971-05-24 Filter syringe Expired - Lifetime US3757779A (en)

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Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4226236A (en) * 1979-05-07 1980-10-07 Abbott Laboratories Prefilled, vented two-compartment syringe
US4781683A (en) * 1987-04-22 1988-11-01 The Johns Hopkins University Single-use, self-annulling injection syringe
US4917101A (en) * 1989-02-27 1990-04-17 Horn Daniel P Vena puncture device and method
US5125908A (en) * 1990-10-19 1992-06-30 Cohen Milton J Hypodermic syringe with protective holder
US5139490A (en) * 1989-07-27 1992-08-18 Arzneimittel Gmbh Apotheker Vetter & Co. Hypodermic syringe
WO1995005598A1 (en) * 1993-08-13 1995-02-23 Hybrivet Systems, Inc. Process and apparatus for testing for substances in liquids
US5397048A (en) * 1992-09-22 1995-03-14 Pioneer Electronic Corporation Needle for applying viscous fluid
US5779668A (en) * 1995-03-29 1998-07-14 Abbott Laboratories Syringe barrel for lyophilization, reconstitution and administration
US5785682A (en) * 1995-03-22 1998-07-28 Abbott Laboratories Pre-filled syringe drug delivery system
US5876372A (en) * 1995-03-22 1999-03-02 Abbott Laboratories Syringe system accomodating seperate prefilled barrels for two constituents
US6080461A (en) * 1990-12-14 2000-06-27 The Johns Hopkins University Viscoelastic memory means and flow control valve and use thereof to produce a single-use, auto-destruct injection device
US20020042592A1 (en) * 2000-10-10 2002-04-11 Wilmot John G. Wet/dry automatic injector assembly
US20030069545A1 (en) * 1999-12-06 2003-04-10 Arm Douglas M. Graft delivery syringe
US6641561B1 (en) * 2000-10-10 2003-11-04 Meridian Medical Technologies, Inc. Drug delivery device
US20040097874A1 (en) * 2000-10-10 2004-05-20 Meridian Medical Technologies, Inc. Separation assembly for drug delivery device
US20040138611A1 (en) * 2000-10-10 2004-07-15 Meridian Medical Technologies, Inc. Wet/dry automatic injector assembly
US6770052B2 (en) 2000-10-10 2004-08-03 Meridian Medical Technologies, Inc. Wet/dry automatic injector assembly
US20040254543A1 (en) * 2000-10-10 2004-12-16 Griffiths Steven M. Needle and hub assembly for automatic injector
JP2005537106A (en) * 2002-09-03 2005-12-08 メリディアン メディカル テクノロジーズ,インコーポレイテッドMeridian Medical Technologies,Inc. Drug delivery device
EP2311513A1 (en) * 2009-10-16 2011-04-20 Sanofi-Aventis Deutschland GmbH Cartridge holder assembly for a drug delivery device
US20130116617A1 (en) * 2010-07-22 2013-05-09 Becton, Dickinson And Company Needle assembly for mixing of substances
US20130317472A1 (en) * 2010-09-28 2013-11-28 Covidien Lp Self-venting cannula assembly
US20160081706A1 (en) * 2013-05-07 2016-03-24 Auxin Surgery Sa Device for chemically assisted dissection
US20160199582A1 (en) * 2011-10-14 2016-07-14 Amgen Inc. Method of assembling and filling a drug delivery device
CN105873626A (en) * 2013-10-24 2016-08-17 美国安进公司 Injector and method of assembly
WO2017089273A1 (en) * 2015-11-27 2017-06-01 Sanofi-Aventis Deutschland Gmbh Medicament injection device
US10486165B2 (en) * 2017-05-09 2019-11-26 Miltengi Biotec, GmbH Refillable column system

Citations (9)

* Cited by examiner, † Cited by third party
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US1943120A (en) * 1930-05-21 1934-01-09 Kabnick Stuart Hypodermic syringe
US2628615A (en) * 1949-12-28 1953-02-17 Jacob A Saffir Hypodermic injection device
US2778360A (en) * 1955-05-09 1957-01-22 Pfizer & Co C Hypodermic syringe
US2807288A (en) * 1954-09-01 1957-09-24 Robert F Shea Sterile drop assembly
US2854977A (en) * 1956-06-15 1958-10-07 Mine Safety Appliances Co Mixing and dispensing device
US3255752A (en) * 1965-01-28 1966-06-14 Dick Peter Hypodermic syringe
US3557787A (en) * 1968-05-28 1971-01-26 Milton J Cohen Disposable syringe
US3592245A (en) * 1968-09-24 1971-07-13 American Home Prod Universal dispensing device for intravenous medications
US3682315A (en) * 1969-10-20 1972-08-08 Wolfgang Haller Cartridge type column for treatment of liquid streams and substrate enclosure therefor

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1943120A (en) * 1930-05-21 1934-01-09 Kabnick Stuart Hypodermic syringe
US2628615A (en) * 1949-12-28 1953-02-17 Jacob A Saffir Hypodermic injection device
US2807288A (en) * 1954-09-01 1957-09-24 Robert F Shea Sterile drop assembly
US2778360A (en) * 1955-05-09 1957-01-22 Pfizer & Co C Hypodermic syringe
US2854977A (en) * 1956-06-15 1958-10-07 Mine Safety Appliances Co Mixing and dispensing device
US3255752A (en) * 1965-01-28 1966-06-14 Dick Peter Hypodermic syringe
US3557787A (en) * 1968-05-28 1971-01-26 Milton J Cohen Disposable syringe
US3592245A (en) * 1968-09-24 1971-07-13 American Home Prod Universal dispensing device for intravenous medications
US3682315A (en) * 1969-10-20 1972-08-08 Wolfgang Haller Cartridge type column for treatment of liquid streams and substrate enclosure therefor

Cited By (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4226236A (en) * 1979-05-07 1980-10-07 Abbott Laboratories Prefilled, vented two-compartment syringe
US4781683A (en) * 1987-04-22 1988-11-01 The Johns Hopkins University Single-use, self-annulling injection syringe
EP0312576A1 (en) * 1987-04-22 1989-04-26 Univ Johns Hopkins Single-use, self-annulling injection syringe.
EP0312576A4 (en) * 1987-04-22 1989-08-09 Univ Johns Hopkins Single-use, self-annulling injection syringe.
WO1988008314A1 (en) * 1987-04-22 1988-11-03 The Johns Hopkins University Single-use, self-annulling injection syringe
US4917101A (en) * 1989-02-27 1990-04-17 Horn Daniel P Vena puncture device and method
US5139490A (en) * 1989-07-27 1992-08-18 Arzneimittel Gmbh Apotheker Vetter & Co. Hypodermic syringe
US5125908A (en) * 1990-10-19 1992-06-30 Cohen Milton J Hypodermic syringe with protective holder
US6080461A (en) * 1990-12-14 2000-06-27 The Johns Hopkins University Viscoelastic memory means and flow control valve and use thereof to produce a single-use, auto-destruct injection device
US5397048A (en) * 1992-09-22 1995-03-14 Pioneer Electronic Corporation Needle for applying viscous fluid
WO1995005598A1 (en) * 1993-08-13 1995-02-23 Hybrivet Systems, Inc. Process and apparatus for testing for substances in liquids
US5567619A (en) * 1993-08-13 1996-10-22 Hybrivet Systems, Inc. Process and apparatus for testing for substances in liquids
US5785682A (en) * 1995-03-22 1998-07-28 Abbott Laboratories Pre-filled syringe drug delivery system
US5876372A (en) * 1995-03-22 1999-03-02 Abbott Laboratories Syringe system accomodating seperate prefilled barrels for two constituents
US5779668A (en) * 1995-03-29 1998-07-14 Abbott Laboratories Syringe barrel for lyophilization, reconstitution and administration
US20030069545A1 (en) * 1999-12-06 2003-04-10 Arm Douglas M. Graft delivery syringe
US7621887B2 (en) 2000-10-10 2009-11-24 Meridian Medical Technologies, Inc. Wet/dry automatic injector assembly
US6641561B1 (en) * 2000-10-10 2003-11-04 Meridian Medical Technologies, Inc. Drug delivery device
US8506526B2 (en) 2000-10-10 2013-08-13 Meridian Medical Technologies, Inc. Seal structures for wet/dry automatic injectors
US20040097874A1 (en) * 2000-10-10 2004-05-20 Meridian Medical Technologies, Inc. Separation assembly for drug delivery device
US20040138611A1 (en) * 2000-10-10 2004-07-15 Meridian Medical Technologies, Inc. Wet/dry automatic injector assembly
US6770052B2 (en) 2000-10-10 2004-08-03 Meridian Medical Technologies, Inc. Wet/dry automatic injector assembly
US20040254543A1 (en) * 2000-10-10 2004-12-16 Griffiths Steven M. Needle and hub assembly for automatic injector
US8568367B2 (en) * 2000-10-10 2013-10-29 Meridian Medical Technologies, Inc. Needle assemblies for wet/dry automatic injectors
US6953445B2 (en) * 2000-10-10 2005-10-11 Meridian Medical Technologies, Inc. Wet/dry automatic injector assembly
US20100228190A1 (en) * 2000-10-10 2010-09-09 Meridian Medical Technologies, Inc. Seal structures for wet/dry automatic injectors
US20020042592A1 (en) * 2000-10-10 2002-04-11 Wilmot John G. Wet/dry automatic injector assembly
US20090205744A1 (en) * 2000-10-10 2009-08-20 Meridian Medical Technologies, Inc. Methods of forming a needle and hub assembly for automatic injectors
US20070123818A1 (en) * 2000-10-10 2007-05-31 Meridian Medical Technologies, Inc. Needle assemblies for wet/dry automatic injectors
US20070142768A1 (en) * 2000-10-10 2007-06-21 Meridian Medical Technologies, Inc. Flow-path inserts for wet/dry automatic injectors
US20070142769A1 (en) * 2000-10-10 2007-06-21 Meridian Medical Technologies, Inc. Seal structures for wet/dry automatic injectors
US7757370B2 (en) 2000-10-10 2010-07-20 Meridian Medical Technologies, Inc. Methods of forming a needle and hub assembly for automatic injectors
US7749190B2 (en) 2000-10-10 2010-07-06 Meridan Medical Technologies, Inc. Seal structures for wet/dry automatic injectors
US7544189B2 (en) 2000-10-10 2009-06-09 Meridian Medical Technologies, Inc. Needle and hub assembly for automatic injector
US7556614B2 (en) 2000-10-10 2009-07-07 Meridian Medical Technologies, Inc. Separation assembly for drug delivery device
US8187220B2 (en) 2000-10-10 2012-05-29 Meridian Medical Technologies, Inc. Seal structures for wet/dry automatic injectors
US7608055B2 (en) * 2000-10-10 2009-10-27 Meridian Medical Technologies, Inc. Flow-path inserts for wet/dry automatic injectors
JP2006272006A (en) * 2000-10-10 2006-10-12 Meridian Medical Technologies Inc Wet/dry automatic injector assembly
WO2004022137A1 (en) * 2001-07-03 2004-03-18 Meridian Medical Technologies, Inc. Drug delivery device
JP2005537106A (en) * 2002-09-03 2005-12-08 メリディアン メディカル テクノロジーズ,インコーポレイテッドMeridian Medical Technologies,Inc. Drug delivery device
AU2002332808C1 (en) * 2002-09-03 2008-11-13 Meridian Medical Technologies, Inc. Drug delivery device
AU2002332808B2 (en) * 2002-09-03 2008-04-24 Meridian Medical Technologies, Inc. Drug delivery device
CN100574822C (en) 2003-10-23 2009-12-30 麦利迪安医药技术有限公司 Wet/dry automatic injector assembly
JP2010162414A (en) * 2003-10-23 2010-07-29 Meridian Medical Technologies Inc Automatic injector and method of assembling the same
JP2010162413A (en) * 2003-10-23 2010-07-29 Meridian Medical Technologies Inc Automatic injector and method of assembling the same
WO2005042067A3 (en) * 2003-10-23 2005-10-06 Meridian Medical Technologies Wet/dry automatic injector assembly
AU2004285456B2 (en) * 2003-10-23 2010-05-27 Meridian Medical Technologies, Inc. Wet/dry automatic injector assembly
EP2308529A3 (en) * 2003-10-23 2011-09-07 Meridian Medical Technologies, Inc. Flow-Path Inserts for Wet/Dry Automatic Injectors
EP2308530A3 (en) * 2003-10-23 2011-09-07 Meridian Medical Technologies, Inc. Needle Assemblies for Wet/Dry Automatic Injectors
JP4896727B2 (en) * 2003-10-23 2012-03-14 メリディアン メディカル テクノロジーズ,インコーポレーテッド Wet / dry automatic syringe assembly
AU2010202607B2 (en) * 2003-10-23 2013-05-02 Meridian Medical Technologies, Inc. Wet/dry automatic injector assembly
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