US3923058A - Multi-chamber syringe - Google Patents

Multi-chamber syringe Download PDF

Info

Publication number
US3923058A
US3923058A US48410474A US3923058A US 3923058 A US3923058 A US 3923058A US 48410474 A US48410474 A US 48410474A US 3923058 A US3923058 A US 3923058A
Authority
US
United States
Prior art keywords
cylinder
barrier
means
end
needle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
Inventor
Charles Z Weingarten
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kendall Co
Original Assignee
Kendall Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US25509972A priority Critical
Application filed by Kendall Co filed Critical Kendall Co
Priority to US48410474 priority patent/US3923058A/en
Application granted granted Critical
Publication of US3923058A publication Critical patent/US3923058A/en
Assigned to MANUFACTURERS HANOVER TRUST COMPANY, AS AGENT reassignment MANUFACTURERS HANOVER TRUST COMPANY, AS AGENT SECURITY INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: KENDALL COMPANY, THE
Anticipated expiration legal-status Critical
Application status is Expired - Lifetime legal-status Critical

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/3129Syringe barrels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/28Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/284Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle comprising means for injection of two or more media, e.g. by mixing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M2005/1787Syringes for sequential delivery of fluids, e.g. first medicament and then flushing liquid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/19Syringes having more than one chamber, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/28Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/285Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened
    • A61M5/286Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened upon internal pressure increase, e.g. pierced or burst

Abstract

A syringe has a floating barrier seal located at approximately the middle of the syringe chamber, thereby forming (at least) two different chambers on opposite sides of the barrier to provide separate storage space for (at least) two different medicines. A hypodermic needle projects inwardly into the adjacent one of the chambers, far enough to pierce the floating barrier after the first medicine has been dispensed. The needle passes through the barrier to dispense the second medicine on the other side of the barrier. At this time, the barrier seals the first medicine away from the needle so that it cannot mix with or contaminate the second medicine.

Description

O United States Patent 11 1 1111 3,923,058 Weingarten 1 1 *Dec. 2, 1975 I 1 MULTI-CHAMBER SYRINGE 2,939,459 6/1960 Lazarte et a1. 128/218 M 3,052,240 9/1962 Silver et a1. 175] inventor: fi wemgarten w'lmette 3,200,813 8/1965 Christakis 128/272 x FOREIGN PATENTS OR APPLICATIONS [73] Ass1gnee: The Kendall Company, Walpole,

Mass 1,201,009 9/1965 Germany 128/218 R 7 6,616,739 5/1967 Netherlands 128/218 R Notice: The portion of the term of thi 996,168 6/1965 United Kingdom... 128/218 M patent Subsequent to July 29 1992 1,054,173 12/1953 France 128/218 R has been disclaime 488,003 12/1953 ltaly 128/221 [22] Filed: June 28, 1974 App]. No.: 484,104

[63] Continuation of Ser. No. 255,099, May 19, 1972,

abandoned.

[52] U.S. Cl. 128/218 R; 128/218 G [51] Int. Cl. A61M 5/00 [58] Field of Search 128/218M,218R,218 D, 128/218 DA, 272, 215, 216, 218 P, 218 F, 218 A, 218 G [56] References Cited UNITED STATES PATENTS 857,739 6/1907 Kennerly et a1 128/218 M 1,767,304 6/1930 Morton 128/218 D 2,159,217 5/1939 Lozier et a1. 128/218 M 2,263,865 11/1941 Bailen 128/218 R 2,489,600 11/1949 Tydings et al 128/218 M 2,687,728 8/1954 Copen 128/218 D Primary ExaminerRobert W. Michell Assistant ExaminerRick Opitz Attorney, Agent, or FirmPowell L. Sprunger 57 ABSTRACT A syringe has a floating barrier seal located at approximately the middle of the syringe chamber, thereby forming (at least) two different chambers on opposite sides of the barrier to provide separate storage space for (at least) two different medicines. A hypodermic needle projects inwardly into the adjacent one of the chambers, far enough to pierce the floating barrier after the first medicine has been dispensed. The needle passes through the barrier to dispense the second medicine on the other side of the barrier. At this time, the barrier seals the first medicine away from the needle so that it cannot mix with or contaminate the second medicine.

6 Claims, 6 Drawing Figures Patent Dec. 2, 1975 F164 F\G.5

F102 FIG.3

FIGJ

MULTI-CHAMBER SYRINGE This is a continuation of application Ser. No. 255,099 filed May 19, 1972, and now abandoned.

This invention relates to syringes for giving multimedicine injections and, more particularly, to syringes which do not allow two or more medicines to mix prior to their sequential injection into a patient.

Syringes are used to inject medicine into the body of a human or an animal. Usually, the injected medication is a single fluid or a mixture, in which case the syringe has a single compartment and a single needle. Sometimes, the medication includes two chemicals or drugs which must be mixed immediately prior to the injection. Here, the syringe usually has two compartments separated by a barrier which either ruptures or opens at the time of injection so that the injected medicine is a single chemical mixture as it passes into the patients body.

When it has been necessary to inject two separate and unmixed chemicals, the customary practice has been to use two separate syringes. This doubles the cost of preparing and administering the mixtures for injection, and it doubles the pain by requiring two punctures of the patients skin.

A suggested alternative is to provide twin, rigidly interconnected syringes which does nothing for the cost, but supposedly gives a single sensation of pain since the two needles are physically too close together to be perceived as more than a single point of contact. Aside from the double cost, this twin syringe requires greater skill on the part of the doctor or nurse administering the medication.

Accordingly, an object of this invention is to provide a syringe for administering two medications which are completely separate and unmixed at the time of injection. Here an object is to provide a syringe having substantially the same cost as a single medication syringe. In this connection, an object is to provide a disposable, double compartment syringe having such a low cost that it may be filled with two or more medications and prepackaged in a sterile container by a pharmaceutical company.

Another object of the invention is to reduce the skill level required to administer a multi-medication injection. Here, an object is to reduce the patients pain and psychological suffering in anticipation of and during the injection.

In keeping with an aspect of this invention, these and other objects of the invention are accomplished by a syringe having a floating barrier therein-at approximately the middle of the syringe chamber. Two different chambers are thereby formed on opposite sides of the floating barrier to separate the two different medications. A single hypodermic needle projects inwardly into the bottom one of the chambers far enough to pierce the floating barrier after substantially all of the first medication has been dispensed. The needle passes through the barrier to thereafter dispense the second medication on the other side of the barrier. At this time, the barrier seals the first medication away from the needle so that it cannotmix with or contaminate the second medication.

The nature of a preferred embodiment of the invention may be understood best from an inspection of the attached drawings wherein:

FIG. 1 is an exploded view, in perspective, of the inventive syringe;

FIGS. 2-5 are stop motion views schematically showing how two medications are separately dispensed so that neither mixes with or contaminates the other prior to injection; and

FIG. 6 schematically shows a method of evacuating the remainder of a first medication after it is no longer being injected into a patient.

The inventive syringe 20 comprises a needle assembly 21, a cylinder 22, a floating barrier seal 23, and a plunger assembly 24. The needle is separated into first and second parts 26, 27, respectively. The first part 26 is sharpened and adapted to pierce the skin of a person or animal receiving the medication. The second part 27 of the needle projects into the cylinder 22 for a distance which is adequate to puncture the barrier 23 when it reaches the bottom of the cylinder. A preferably plastic collar 28 is firmly attached to the needle 21 at the junction point between the two parts 26, 27. The collar 28 includes two oppositely disposed ears 29, 30 which cooperate with internal threads in the syringe to attach the needle thereto.

The cylinder 22 is an elongated hollow tube of uniform cross-section, terminated at the bottom in an internally threaded coupler 35. Concentrically positioned inside coupler is a tube 36 having an axial opening therein to receive the needle 27 with a sufficiently tight seal to preclude leaking. The threads 37 inside the coupler 35 engage and receive the ears 29, 30 on the collar 28. Thus, as the assembly 28 is rotated, the two parts 28, 35 come together with a tight seal.

The upper end of the cylinder 22, has opposing tabs 38, 39 which are held by the index and middle fingers of the person administering the injection. The upper end 40 of the cylinder 22 is beveled to provide a conical entrance for guiding and directing the barrier 23 and plunger 24 members upon entrance into the cylinder. The entire unit is preferably made from low cost, thin-walled, transparent plastic material so that the person administering the injection can watch the operation to be sure that the medications are properly fed into the patient.

According to the invention, a floating barrier member 23 is provided for forming two separate chambers in the tube. Preferably, this barrier is a soft rubber plug which has two longitudinally displaced piston rings 41, 42 for making a good seal against the interior wall of the cylinder 22. The bottom 44 of the plug is somewhat conical to help guide it on its entrance into the cylinder 22. An axial bore 45 almost completely pierces the plug forming the floating barrier member 23. However, the bottom of the bore 45 does not quite extend through the bottom of the plug. Therefore, the bottom of the bore 45 is covered by a thin membrane 46 to prevent any fluid from passing through the barrier.

The plunger assembly 24 comprises a ram rod 50 having a soft rubber plug 51 attached to the bottom and a thumb pad 52 attached to the other end. The plugs 23 and 51 are almost identical, both slide inside the cylinder 22.

The method of its use is illustrated by the stop motion views of FIGS. 2-5. Preferably, a pharmaceutical manufacturer loads the inventive syringe in his laboratory or factory by depositing a first medicine 54 in the bottom of the cylinder 22. Then, the barrier 23 is placed in the tube and brought down into contact with the top of v the medicine surface, to eliminate all entrapped air.

One way of doing this is to invert the syringe, allow the entrapped air to escape through the tube 36, and then 3 to seal the tube.

After the first medicine 54 is loaded into the first compartment, a second medicine 55 is loaded into the second compartment. Then, the plunger assembly 24 is brought down into contact with the upper surface of the second medicine, and all entrapped air is withdrawn. One way to withdraw the entrapped air is to slip a small tube of hypodermic needle stock between the soft rubber plug 51 and the inside surface of the cylinder 22 and to vacuum pump the air from the upper chamber. The inventive syringe (FIG. 2) is now preloaded with two completely separated medications 54, 55, held securely apart, one from the other.

As the injection is given (FIG. 3), only the first medicine passes out of the chamber 22 and through the needle 26, into the patient. As the first medicine is exhausted, the floating barrier 23 engages and is pierced by the upper end 27 of the needle 21. It is easy to so pierce the floating barrier since only the thin membrane 46 is present at this point. Thereafter, the needle end 27 is in the bore 45 which provides an unimpeded passage for the medicine in the upper chamber. The rubber-like material of the floating barrier surrounds and seals the outside of the needle 27 and prevents any more of the first medicine 54 from passing through the needle.

At this time (FIG. 4), the second medicine 55 passes through the needle 27 and into the patient receiving the injection. The second medicine is not mixed with or contaminated by the first medicine at any time before or during the injection.

At the bottom of the stroke (FIG. 5), the plug 51 reaches the top of the barrier 23 or the needle 27, where it terminates the flow of the medicine through the needle. The medicine is now exhausted, and the spent syringe is discarded.

It is apparent that the same principle may be extended to an administration of a larger number of medicines by increasing the number of floating barriers and, therefore, the number of separate compartments inside the cylinder 22. The membrane member 46 is thin enough and the rubber plug 23 is soft enough so that the needle top 27 may penetrate the bore 45 far enough to admit the second medicine 55 to the needle. However, sometimes the first medicine 54 entrapped under the floating barrier 23 should be evacuated to relieve pressure and to allow the barrier 23 to settle further into the cylinder 22. This is especially true if there are two or more floating barriers. The first barrier must settle to allow the second barrier to be pierced by the needle 27.

To provide relief from the back pressure of the first medication, the cylinder 22 is weakened at a point 60 in the entrapped area 61. An adjacent chamber 62 is positioned to communicate with the entrapped area 61 when the weakened point 60 ruptures. As the first medicine 54 is ejected from the cylinder 22, the pressure does not exceed the rupture strength of the weakened area 60. However, when the medication 54 flow is blocked by the needle end 27 passing through the floating barrier, the fluid pressure builds in the entrapped area 61. Weakened area 60 ruptures under the augmented pressure, and the entrapped medication flows from area 61 into a closed and, perhaps, evacuated chamber 62. As the fluid flows from area 61, the barrier 23 settles further into cylinder 22 in order to enable the needle end 27 to properly perform its penetration function. There cannot be a reverse flow since the punctured membrane 46 of the floating barrier 23 seals itself around the outside periphery of the needle. Moreover, any pressure differential is such that the flow will be from the cylinder 22 into the chamber 62.

It should be understood that modifications may be made without departing from the scope of the invention. Therefore, the appended claims should be construed to cover all equivalent structures.

I claim:

1. A multi-chamber syringe comprising a cylinder having at least one floating barrier means therein forming at least two separate chambers, with each of said chambers containing a liquid, a plunger received in said cylinder, hollow needle means attached to one end of said cylinger and having an unbroken cylindrical shell initially communicating with the chamber intermediate the barrier means and said one end of the cylinder, said shell projecting into said cylinder far enough to puncture and seal said barrier around the periphery of said unbroken cylindrical needle shell to prevent the liquids in the two chambers from mixing when said barrier nears the en of its travel as said syringe is emptied responsive to movement of said plunger, and means associated with said cylinder between said one end and said barrier means for relieving back pressure on said barrier after said needle punctures said barrier whereby said barrier may continue to settle after having been punctured and whereby said continued settling occurs without introduction of the contents of one of said chambers into the other of said chambers.

2. The syringe of claim 1 wherein said floating barrier means comprises a soft plug having at least one integrally formed circumferential piston ring and an axial bore closed by a membrane.

3. The syringe of claim 2 wherein said means for relievingback pressure comprises an unbroken but weakened wall area near the bottom of the stroke between said cylinder and said barrier means, whereby said weakened wall area ruptures under augmented pressure to so receive said back pressure and evacuate the liquid under the floating barrier.

4. The structure of claim 1 and a third closed chamber positioned adjacent said means for relieving said back pressure after said barrier means is punctured, said means for relieving back pressure comprising a weakened rupture area in the wall between said chamber near the end of said barrel travel and said third closed chamber.

5. A syringe comprising a cylinder, a plunger received in one end of the cylinder, a floating barrier received in the cylinder intermediate the plunger and the other end of the cylinder, and a closed chamber adjacent said cylinder with a wall common to said cylinder, a needle extending into said cylinder to pierce said barrier at a predetermined point in the stroke of said plunger, and a weakened rupture area in said common wall between the end of said needle inside said cylinder and the point where said needle is attached to said syringe.

6. A multi-chamber syringe, comprising:

a hollow cylinder for retaining a liquid;

floating barrier means received in the cylinder defining a first chamber intermediate the barrier means and one end of the cylinder and a second chamber intermediate the barrier means and the other end of the cylinder, with both of said chambers containing a portion of said liquid;

3 ,9 23 ,05 8 5 6 a plunger received in the one cylinder end for pumpinto the y q and ing liquid out of the Cylinder. means for diverting and emptying liquid from the secnd chamber after a portion of the liquid is ejected hollow needle means attached to the other cylinder from the Second chamber through the needle end and projecting a sufficient distance into said means" cylinder to puncture and seal said barrier means without mixing liquid between the first and second chambers responsive to movement of the plunger

Claims (6)

1. A multi-chamber syringe comprising a cylinder having at least one floating barrier means therein forming at least two separate chambers, with each of said chambers containing a liquid, a plunger received in said cylinder, hollow needle means attached to one end of said cylinger and having an unbroken cylindrical shell initially communicating with the chamber intermediate the barrier means and said one end of the cylinder, said shell projecting into said cylinder far enough to puncture and seal said barrier around the periphery of said unbroken cylindrical needle shell to prevent the liquids in the two chambers from mixing when said barrier nears the en of its travel as said syringe is emptied responsive to movement of said plunger, and means associated with said cylinder between said one end and said barrier means for relieving back pressure on said barrier after said needle punctures said barrier whereby said barrier may continue to settle after having been punctured and whereby said continued settling occurs without introduction of the contents of one of said chambers into the other of said chambers.
2. The syringe of claim 1 wherein said floating barrier means comprises a soft plug having at least one integrally formed circumferential piston ring and an axial bore closed by a membrane.
3. The syringe of claim 2 wherein said means for relieving back pressure comprises an unbroken but weakened wall area near the bottom of the stroke between said cylinder and said barrier means, whereby said weakened wall area ruptures under augmented pressure to so receive said back pressure and evacuate the liquid under the floating barrier.
4. The structure of claim 1 and a third closed chamber positioned adjacent said means for relieving said back pressure after said barrier means is punctured, said means for relieving back pressure comprising a weakened rupture area in the wall between said chamber near the end of said barrel travel and said third closed chamber.
5. A syringe comprising a cylinder, a plunger received in one end of the cylinder, a floating barrier received in the cylinder intermediate the plunger and the other end of the cylinder, and a closed chamber adjacent said cylinder with a wall common to said cylinder, a needle extending into said cylinder to pierce said barrier at a predetermined point in the stroke of said plunger, and a weakened rupture area in said common wall between the end of said needle inside said cylinder and the point where said needle is attached to said syringe.
6. A multi-chamber syringe, comprising: a hollow cylinder for retaining a liquid; floating barrier means received in the cylinder defining a first chamber intermediate the barrier means and one end of the cylinder and a second chamber intermediate the barrier means and the other end of the cylinder, with both of said chambers containing a portion of said liquid; a plunger received in the one cylinder end for pumping liquid out of the cylinder; hollow needle means attached to the other cylinder end and projecting a sufficient distance into said cylinder to puncture and seal said barrier means without mixing liquid between the first and second chambers responsive to movement of the plunger into the cylinder; and means for diverting and emptying liquid from the second chamber after a portion of the liquid is ejected from the second chamber through the needle means.
US48410474 1972-05-19 1974-06-28 Multi-chamber syringe Expired - Lifetime US3923058A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US25509972A true 1972-05-19 1972-05-19
US48410474 US3923058A (en) 1972-05-19 1974-06-28 Multi-chamber syringe

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US48410474 US3923058A (en) 1972-05-19 1974-06-28 Multi-chamber syringe

Publications (1)

Publication Number Publication Date
US3923058A true US3923058A (en) 1975-12-02

Family

ID=26944433

Family Applications (1)

Application Number Title Priority Date Filing Date
US48410474 Expired - Lifetime US3923058A (en) 1972-05-19 1974-06-28 Multi-chamber syringe

Country Status (1)

Country Link
US (1) US3923058A (en)

Cited By (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4702737A (en) * 1986-07-14 1987-10-27 Pizzino Joanne L Dual dose syringe
EP0287950A2 (en) * 1987-04-24 1988-10-26 Aldo Venturini Disposable safety seringe
US4908022A (en) * 1988-08-15 1990-03-13 Habley Medical Technology Corporation Disposable safety syringe having a retractable needle cannula and cannula lock
US5308322A (en) * 1993-04-19 1994-05-03 Tennican Patrick O Central venous catheter access system
US5476449A (en) * 1992-12-28 1995-12-19 Richmond; Frank M. Needleless multi-liquid medicament delivery system with membranes
WO2001012101A1 (en) * 1999-08-18 2001-02-22 Interag Multiple material dispensing
US20040044316A1 (en) * 2002-08-30 2004-03-04 Greenfield Christian John Syringe for sequential delivery of different fluids
US20040171984A1 (en) * 2002-08-30 2004-09-02 Greenfield Christian John Syringe for sequential delivery of different fluids
US20050171506A1 (en) * 2004-02-02 2005-08-04 Stephen Hallahan Method and device
US20060258977A1 (en) * 2005-05-02 2006-11-16 Lee Martin N Autoflush syringe
US8172929B2 (en) * 2007-04-30 2012-05-08 Medtronic Minimed, Inc. Systems and methods allowing for reservoir air bubble management
US20130116657A1 (en) * 2004-02-02 2013-05-09 Bimeda Research & Development Limited Method and device
US8529517B2 (en) 2005-05-02 2013-09-10 Shi Zi Technology, Ltd. Autoflush syringe
WO2014093926A1 (en) * 2012-12-14 2014-06-19 Larson Bryan Dual medicament carpule for dental syringes
US20140276039A1 (en) * 2013-03-13 2014-09-18 Medrad, Inc. Multiple compartment syringe
US8936577B2 (en) 2005-05-02 2015-01-20 Shi Zi Technology, Ltd. Methods and devices for autoflush syringes
WO2015009746A3 (en) * 2013-07-19 2015-04-23 Icu Medical, Inc. Pressure-regulating fluid transfer systems and methods
USD755957S1 (en) 2013-12-13 2016-05-10 Bryan Larson Dental carpule
US9351905B2 (en) 2008-08-20 2016-05-31 Icu Medical, Inc. Anti-reflux vial adaptors
US9522225B2 (en) 2007-04-30 2016-12-20 Medtronic Minimed, Inc. Adhesive patch systems and methods
US9610217B2 (en) 2012-03-22 2017-04-04 Icu Medical, Inc. Pressure-regulating vial adaptors
US9615997B2 (en) 2013-01-23 2017-04-11 Icu Medical, Inc. Pressure-regulating vial adaptors
US9662272B2 (en) 2006-04-12 2017-05-30 Icu Medical, Inc. Devices and methods for transferring fluid to or from a vial
US9694134B2 (en) 2013-09-16 2017-07-04 Zoetis Services Llc Assembly for sequentially delivering substances, and associated methods
US9763855B2 (en) 2013-01-23 2017-09-19 Icu Medical, Inc. Pressure-regulating vial adaptors
US9855385B2 (en) 2013-03-13 2018-01-02 Bayer Healthcare Llc Multiple compartment syringe
US9895291B2 (en) 2011-08-18 2018-02-20 Icu Medical, Inc. Pressure-regulating vial adaptors
US9901514B2 (en) 2007-04-30 2018-02-27 Medtronic Minimed, Inc. Automated filling systems and methods
WO2018050709A1 (en) 2016-09-15 2018-03-22 Edix Sa Syringe-connector device for the separate administration of controlled quantities at least two products in a single injection
US9987195B2 (en) 2012-01-13 2018-06-05 Icu Medical, Inc. Pressure-regulating vial adaptors and methods
US10201476B2 (en) 2014-06-20 2019-02-12 Icu Medical, Inc. Pressure-regulating vial adaptors
US10292904B2 (en) 2016-01-29 2019-05-21 Icu Medical, Inc. Pressure-regulating vial adaptors

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US857739A (en) * 1906-10-16 1907-06-25 Charles W Kennerly Fountain hypodermic syringe.
US1767304A (en) * 1927-12-30 1930-06-24 Henry S Morton Injection apparatus
US2159217A (en) * 1937-11-05 1939-05-23 Cook Lab Inc Controllable transfer element for multiple ampules
US2263865A (en) * 1939-11-22 1941-11-25 Bailen Jacob Lewis Syringe
US2489600A (en) * 1948-04-02 1949-11-29 Kenneth S Tydings Hypodermic needle
US2687728A (en) * 1951-04-25 1954-08-31 Copen Simon Irving Combination of several solutions for the hypodermic injection
US2939459A (en) * 1957-01-11 1960-06-07 Jorge A Lazarte Tandem syringe
US3052240A (en) * 1959-01-29 1962-09-04 Silver Disposable hypodermic syringe
US3200813A (en) * 1962-12-24 1965-08-17 George J Christakis Aspirating syringes

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US857739A (en) * 1906-10-16 1907-06-25 Charles W Kennerly Fountain hypodermic syringe.
US1767304A (en) * 1927-12-30 1930-06-24 Henry S Morton Injection apparatus
US2159217A (en) * 1937-11-05 1939-05-23 Cook Lab Inc Controllable transfer element for multiple ampules
US2263865A (en) * 1939-11-22 1941-11-25 Bailen Jacob Lewis Syringe
US2489600A (en) * 1948-04-02 1949-11-29 Kenneth S Tydings Hypodermic needle
US2687728A (en) * 1951-04-25 1954-08-31 Copen Simon Irving Combination of several solutions for the hypodermic injection
US2939459A (en) * 1957-01-11 1960-06-07 Jorge A Lazarte Tandem syringe
US3052240A (en) * 1959-01-29 1962-09-04 Silver Disposable hypodermic syringe
US3200813A (en) * 1962-12-24 1965-08-17 George J Christakis Aspirating syringes

Cited By (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4702737A (en) * 1986-07-14 1987-10-27 Pizzino Joanne L Dual dose syringe
EP0287950A3 (en) * 1987-04-24 1990-05-09 Aldo Venturini Disposable safety seringe
EP0287950A2 (en) * 1987-04-24 1988-10-26 Aldo Venturini Disposable safety seringe
US4908022A (en) * 1988-08-15 1990-03-13 Habley Medical Technology Corporation Disposable safety syringe having a retractable needle cannula and cannula lock
US5476449A (en) * 1992-12-28 1995-12-19 Richmond; Frank M. Needleless multi-liquid medicament delivery system with membranes
US5308322A (en) * 1993-04-19 1994-05-03 Tennican Patrick O Central venous catheter access system
WO2001012101A1 (en) * 1999-08-18 2001-02-22 Interag Multiple material dispensing
US7083590B1 (en) 1999-08-18 2006-08-01 Interag Multiple material dispensing
US7077827B2 (en) 2002-08-30 2006-07-18 Christian John Greenfield Syringe for sequential delivery of different fluids
US20040171984A1 (en) * 2002-08-30 2004-09-02 Greenfield Christian John Syringe for sequential delivery of different fluids
US20040044316A1 (en) * 2002-08-30 2004-03-04 Greenfield Christian John Syringe for sequential delivery of different fluids
US20050171506A1 (en) * 2004-02-02 2005-08-04 Stephen Hallahan Method and device
US9180249B2 (en) * 2004-02-02 2015-11-10 Bimeda Research & Development Limited Method and device
US20130116657A1 (en) * 2004-02-02 2013-05-09 Bimeda Research & Development Limited Method and device
US8353877B2 (en) 2004-02-02 2013-01-15 Bimeda Research & Development Limited Method for administering two components into the teat canal of a non-human animal
US7828765B2 (en) 2004-02-02 2010-11-09 Bimeda Research & Development Ltd Method and device for administering two components into the teat canal of a non-human animal
US20110022000A1 (en) * 2004-02-02 2011-01-27 Bimeda Research & Development Limited Method and device
US8936577B2 (en) 2005-05-02 2015-01-20 Shi Zi Technology, Ltd. Methods and devices for autoflush syringes
US8075533B2 (en) * 2005-05-02 2011-12-13 Preventiv, Inc. Autoflush syringe
US8075547B2 (en) 2005-05-02 2011-12-13 Preventiv, Inc. Autoflush syringe method
US20100114068A2 (en) * 2005-05-02 2010-05-06 Martin Lee Autoflush Syringe Method
US20090287184A1 (en) * 2005-05-02 2009-11-19 Martin Nicholas Lee Autoflush Syringe Method
US8529517B2 (en) 2005-05-02 2013-09-10 Shi Zi Technology, Ltd. Autoflush syringe
US20060258977A1 (en) * 2005-05-02 2006-11-16 Lee Martin N Autoflush syringe
US10322236B2 (en) 2005-05-02 2019-06-18 Bee Sight Limited Methods and devices for autoflush syringes
US9539391B2 (en) 2005-05-02 2017-01-10 Shi Zi Technology, Ltd. Methods and devices for autoflush syringes
US10327993B2 (en) 2006-04-12 2019-06-25 Icu Medical, Inc. Vial access devices
US10327989B2 (en) 2006-04-12 2019-06-25 Icu Medical, Inc. Devices and methods for transferring fluid to or from a vial
US10327992B2 (en) 2006-04-12 2019-06-25 Icu Medical, Inc. Fluid transfer apparatus with pressure regulation
US9662272B2 (en) 2006-04-12 2017-05-30 Icu Medical, Inc. Devices and methods for transferring fluid to or from a vial
US9993390B2 (en) 2006-04-12 2018-06-12 Icu Medical, Inc. Pressure-regulating vial adaptors and methods
US10327991B2 (en) 2006-04-12 2019-06-25 Icu Medical, Inc. Fluid transfer apparatus with filtered air input
US10071020B2 (en) 2006-04-12 2018-09-11 Icu Medical, Inc. Devices for transferring fluid to or from a vial
US9993391B2 (en) 2006-04-12 2018-06-12 Icu Medical, Inc. Devices and methods for transferring medicinal fluid to or from a container
US10022302B2 (en) 2006-04-12 2018-07-17 Icu Medical, Inc. Devices for transferring medicinal fluids to or from a container
US8172929B2 (en) * 2007-04-30 2012-05-08 Medtronic Minimed, Inc. Systems and methods allowing for reservoir air bubble management
US9522225B2 (en) 2007-04-30 2016-12-20 Medtronic Minimed, Inc. Adhesive patch systems and methods
US9901514B2 (en) 2007-04-30 2018-02-27 Medtronic Minimed, Inc. Automated filling systems and methods
US9980879B2 (en) 2007-04-30 2018-05-29 Medtronic Minimed, Inc. Automated filling systems and methods
US9351905B2 (en) 2008-08-20 2016-05-31 Icu Medical, Inc. Anti-reflux vial adaptors
US9931275B2 (en) 2008-08-20 2018-04-03 Icu Medical, Inc. Anti-reflux vial adaptors
US9895291B2 (en) 2011-08-18 2018-02-20 Icu Medical, Inc. Pressure-regulating vial adaptors
US9987195B2 (en) 2012-01-13 2018-06-05 Icu Medical, Inc. Pressure-regulating vial adaptors and methods
US10299989B2 (en) 2012-03-22 2019-05-28 Icu Medical, Inc. Pressure-regulating vial adaptors
US9610217B2 (en) 2012-03-22 2017-04-04 Icu Medical, Inc. Pressure-regulating vial adaptors
US9055992B2 (en) 2012-12-14 2015-06-16 Bryan Larson Dual medicament carpule for dental syringes
WO2014093926A1 (en) * 2012-12-14 2014-06-19 Larson Bryan Dual medicament carpule for dental syringes
US9763855B2 (en) 2013-01-23 2017-09-19 Icu Medical, Inc. Pressure-regulating vial adaptors
US9615997B2 (en) 2013-01-23 2017-04-11 Icu Medical, Inc. Pressure-regulating vial adaptors
US10117807B2 (en) 2013-01-23 2018-11-06 Icu Medical, Inc. Pressure-regulating devices for transferring medicinal fluid
US20140276039A1 (en) * 2013-03-13 2014-09-18 Medrad, Inc. Multiple compartment syringe
US9855385B2 (en) 2013-03-13 2018-01-02 Bayer Healthcare Llc Multiple compartment syringe
US9114215B2 (en) * 2013-03-13 2015-08-25 Bayer Medical Care Inc. Multiple compartment syringe
CN105722493A (en) * 2013-07-19 2016-06-29 伊库医学有限公司 Pressure-regulating fluid transfer systems and methods
WO2015009746A3 (en) * 2013-07-19 2015-04-23 Icu Medical, Inc. Pressure-regulating fluid transfer systems and methods
US9694134B2 (en) 2013-09-16 2017-07-04 Zoetis Services Llc Assembly for sequentially delivering substances, and associated methods
USD755957S1 (en) 2013-12-13 2016-05-10 Bryan Larson Dental carpule
US10201476B2 (en) 2014-06-20 2019-02-12 Icu Medical, Inc. Pressure-regulating vial adaptors
US10292904B2 (en) 2016-01-29 2019-05-21 Icu Medical, Inc. Pressure-regulating vial adaptors
WO2018050709A1 (en) 2016-09-15 2018-03-22 Edix Sa Syringe-connector device for the separate administration of controlled quantities at least two products in a single injection

Similar Documents

Publication Publication Date Title
US3489147A (en) Combination mixing and injecting medical syringe
US3563373A (en) Hypodermic syringe assembly
US3348546A (en) Intermixing syringe
US3336924A (en) Two compartment syringe package
US3330281A (en) Combination syringe and vial mixing container
US3578037A (en) Method for filling a syringe
US3376866A (en) Medicament injector with attached vial
US3477431A (en) Combined mixing syringe and container
CA2215912C (en) Pre-filled syringe drug delivery system
US6692468B1 (en) Dual-chamber syringe and methods
US6641565B1 (en) drug delivery systems and methods
US4084588A (en) Parenteral drug storage device with closure piercing coupling member
JP4216466B2 (en) Fluid transfer assembly
AU670592B2 (en) Injection cartridge arrangement
CA1310871C (en) Method and device for injection
JP3431629B2 (en) Multi-chamber type injection cartridge
US3810469A (en) Multiple compartment hypodermic devices
US8667997B2 (en) Method and apparatus for the handling of a hazardous fluid
EP0340880B1 (en) Syringe
EP0637443B1 (en) Drug access assembly for vials and ampules
US7678333B2 (en) Fluid transfer assembly for pharmaceutical delivery system and method for using same
CA1333553C (en) Disposable needleless injection system
US4537593A (en) Self-venting, non-coring needle assembly
US5830193A (en) Syringe
JP5519144B2 (en) Syringes for administration of pasty or semisolid preparations

Legal Events

Date Code Title Description
AS Assignment

Owner name: MANUFACTURERS HANOVER TRUST COMPANY, AS AGENT

Free format text: SECURITY INTEREST;ASSIGNOR:KENDALL COMPANY, THE;REEL/FRAME:005251/0007

Effective date: 19881027