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US3592245A - Universal dispensing device for intravenous medications - Google Patents

Universal dispensing device for intravenous medications Download PDF

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Publication number
US3592245A
US3592245A US3592245DA US3592245A US 3592245 A US3592245 A US 3592245A US 3592245D A US3592245D A US 3592245DA US 3592245 A US3592245 A US 3592245A
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Grant
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Prior art keywords
container
parenteral
solution
package
medicament
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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Inventor
Ralph S Levi
Howard J Levin
Stephen W Goodsir
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Wyeth LLC
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Wyeth LLC
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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D47/00Closures with filling and discharging, or with discharging, devices
    • B65D47/04Closures with discharging devices other than pumps
    • B65D47/06Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/1443Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters
    • A61J1/145Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters using air filters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/1443Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters
    • A61J1/1456Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters using liquid filters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/1468Containers characterised by specific material properties

Abstract

The disclosure is directed to a universal dispensing package for medicaments to be dissolved in a parenteral container prior to use. A container is provided with a cap which first, has a hollow piercing device for dispensing a contained medicament into a ''''closed system'''' parenteral solution container, and, second, has a frustoconical shank adapted to engage the interior surface of the neck of an ''''open system'''' parenteral solution container. A membrane filter may be disposed between the container and the cap. An outer sheath is provided over the cap and is scaled in place.

Description

United States Patent [72] lnventors George H. Schneller Devon; Ralph S. Levi, Norristown; Howard J. Levin,'Norristown; Stephen W. Goodsir, King of Prussia, allot, Pa. [21] Appl. No. 762,063 [22] Filed Sept. 24, 1968 [45] Patented July 13, 1971 [73] Assignee American Home Products Corporation New York, N.Y.

[54] UNIVERSAL DISPENSING DEVICE FOR INTRAVENOUS MEDICATIONS 7 Claims, 4 Drawing Figs.

[52] U.S.Cl 141/25, 128/272, 141/24, 141/114, 141/329 [51] Int. Cl A61] 1100 [50] Field 01 Search 128/272; 141/18, 19, 2126, 114, 313, 329, 330; 222/563; 215/47 [56] References Cited UNITED STATES PATENTS 729,835 6/1903 Barnes et a1. 215/47 3,307,552 3/1967 Strawn 215/47 (UX) Primary ExaminerLaveme D. Geiger Assistant Examiner-Edward J. Earls Attorney-Joseph Martin Weigman ABSTRACT: The disclosure is directed to a universal dispensing package for medicaments to be dissolved in a parenteral container prior to use. A container is provided with a cap which first, has a hollow piercing device for dispensing a contained medicament into a closed system parenteral solution container, and, second, has a frustoconical shank adapted to engage the interior surface of the neck of an open system" parenteral solution container. A membrane filter may be disposed between the container and the cap. An outer sheath 1 is provided over the cap and is scaled in place.

UNIVERSAL DISPENSING DEVICE FOR INTRAVENOUS MEDICATIONS This invention is directed to a universal dispensing package for dispensing sterile medicaments and to a method for preparing injectable solutions of such medicaments by transferring the medicament from the dispensing package to a parenteral solution container under substantially aseptic conditions. The dispensing package is adapted to aseptically transfer its contents to both open system" and closed system" parenteral solution containers. .An "open system" parenteral solution container, typically glass, is one having a threaded closure which is removed in order to discharge the contents. A "closed system parenteral solution container, typically glass, is one having a fixed plug, typically rubber, which is perforated by a sharp conduit, typically a hollow plastic needle, in order to remove the contents. Another type of closed system which has recently become available is made of flexible plastic and has a plastic membrane closure which is perforated by a sharp conduit. 1 l

The method may be practiced by transferring a sterile medicament, such as a powder, a lyophilized cake or a solution, to a parenteral solution container of diluent adapted for parenteral injection, irrigation or the like, the transfer being accomplished with maximum protection to sterility.

It is common practice to add medicaments to parenteral solutions in their containers at the time the parenteral solutions are administered. The additives may be antibiotics such as sodium ampicillin, muscle relaxants, such as succinylcholine chloride, and others. The parenteral solution may be a saline solution, glucose-saline solution or other isotonic solution, such as is commonly employed for parenteral administration. Such solutions are usually administered intravenously but may be otherwise parenterally administered or may be used for irrigation.

The added medicaments are usually solutions, powders, or lyophilized cakes. Previously available means for bringing the powders or cakes into solution and for transferring the resulting solution to the bulk parenteral solution have been cumbersome and complicated and not devoid of risk to the sterility of the product contained.

There are two principal forms of containers for the parenteral solutions. More than half of the total market for intravenous fluids is supplied in closed-system containers as they are defined above, while the remainder of the market is supplied in open-type containers as defined above. There are various dispensing packages for medicaments to be used in conjunction with parenteral solution containers. Typicalpackages are described in US. Pat. Nos. 2,957,501; 2,957,609; 3,059,643, and 3,143,251. There is, however, no dispensing package available which may be used conveniently with both the closed-system and open-system parenteral solution containers with complete assurance of maintenance of sterility.

Numerous parenteral powders for reconstitution containing antibiotics and other medicaments are commercially available. A problem has been that in the manufacture of such powders, it is extremely difficult to control the particulate matter content at a satisfactory level and consequently the solutions ultimately prepared from such powders often contain substantial particulate matter counts. Commonly available antibiotics and other powdered injectable products suffer from this disadvantage. Increasingly higher standards for parenterals indicate that the amount of particulate matter should be greatly reduced.

Even in the instances of drugs marketed in the form. of solutions which may be originally packaged substantially free of particulate matter, it is well known to those skilled in.the art that the amount of particulate matter may increase substantially during the shelf life of the product as a result of contact with package components, trace drug decomposition and the like. Such solutions after the development of the particulate matter are still suitable for their intended use if the particulate matter is removed. The particulate matter may not be visible to the naked eye, and consequently the user may be unaware of its presence, and yet it might be potentially harmful. A dispensing package which overcomes this problem is described in copending application Ser. No. 742,872, filed by Howard J. Levin on July 5, I968 and entitled .Package. In that application a package utilizing a membrane filter for the removal of particulate matter is disclosed.

It is an object of the present invention to provide apparatus for the addition of medicaments to both open and closedsystem containers of intravenous parenteral mixtures which provides for the filtration of the medication added to the intravenous parenteral mixtures.

It is another object of the present invention to provide a universal dispensing package for medicaments which are to be added to parenteral solutions which may be used with powders that are not free flowing or are hygroscopic, and can be used with liquids and nonhygroscopic powders as well.

It is another object of the present invention to provide a method ofdissolving medicaments in a parenteral solution in a convenient aseptic manner and which provides control of the particulate matter contributed by the added medication.

Other and further objects of the present invention will be apparent to those skilled in the art from reading the following description taken in conjunction with the drawings, in which:

FIG. I is a sectional view of a dispensing package embodying the features of the present invention;

FIG. 2 is a partial sectional view showing the embodiment of FIG. 1 in use in conjunction with a closed-system intravenous container;

FIG. 3 is a partial sectional view showing the embodiment of FIG. I used in conjunction with an open-system intravenous container; and

FIG. 4 is a detail view of an alternate embodiment of the dispensing package of FIG. 1.

The objects of the present invention may be achieved with a medicament dispensing package which is made up of a reservoir adapted to contain the medicament, a substantially frustoconical cap containing a conduit adapted to convey the medicament from the reservoir to a parenteral solution container, and means to retain the medicament in the reservoir during storage. The frustoconical cap is shaped to have, first, a tapered shank portion adapted to engage the interior surfaces of the mouthof an open-system parenteral solution container and, second, a piercing device adapted to pierce the closure of a closed-system parenteral solution container. While the preferred embodiment utilizes a variable-volume, plastic reservoir, a fixed-volume reservoir-such as a glass or plastic bottle may also be utilized.

A preferred embodiment of the present invention is shown in FIG. I. A universal dispensing package 10 is made up ofa container, or reservoir, 12, a cap 14, a filter 16, a protective sheath 18 and a seal band 20, and contains a medicament 22. The container 12 has a neck 24 provided with threads 26. At the lower portion of the neck 24 is an external flange 28 having a series of knurls, or lugs, 30.

The cap 14 has a shank 32 which has internal threads 34 adapted to cooperate with the threads 26 of the neck 24 to provide a screw-type engagement. The outer surface 36 0f the shank 32 tapers from a proximal periphery 31 to a distal periphery 33 and generally defines a truncated cone, as shown. The outer surface 36 may have a patterned configuration such as fluting 37, defined on it to adapt it better to cooperate with the interior of the neck of an open-system parenteral solution container as described below. A transition piece 38 extends from the shank 32 and with it defines a shoulder 40. A piercing device 42 is provided at the end of the transition piece 38. The piercing device 42, the transition piece 38 and the shank 32 are hollow, and together define a conduit 44. An inner surface 46 is defined in the shank and with the upper edge seat for the filter 16.

The protective sheath l8 surrounds the entire cap 14 and is held in place by the-sealing band 20 whichmay surround the portion 25 of the container 12 defines a lower portion of the protective sheath l8 and extend from a shoulder 48 on the sheath to a point below the flange 28 and be crimped around the flange. The knurls 30 prevent rotation of the sealing band 20.

The patterned configuration on the surface 36 may take one or more of a number of forms designed to make the surface sufficiently flexible sealably to engage the inner surface 60 of an open-system parenteral solution container. To provide an effective seal the form selected should be relatively short in extension from proximal periphery 31 to distal periphery 33. The patterned configuration may be formed by lightly roughening the surface 36. The surface configuration may be formed by making a series of short discontinuous cuts on the surface, for instance in the form of X's or Ys. Other configurations are also effective. The preferred form, however, is the fluting 37 which, as is shown in the drawings, is a plurality of annular yieldable protuberances, or depressions, defined in the outer surface 36.

Whilethe preferred embodiment utilizes the filter 16 to retain the medicament 22 and for other purposes, it is to be understood that the filter may be eliminated and other means used to retain the medicaments. in FIG. 4 is shown an alternative embodiment in which a sheath 19 has a stud 50 formed in it. The stud 50 is adapted to engage the channel 44 inside the piercing device 42. The stud thus fills the end of the conduit, provides a tight seal, and retains the medicament. The filter 16 may be omitted, if desired, in such an embodiment.

The entire dispensing package may be placed in an outerwrap of plastic, metal foil, or combinations thereof or a rigid, hermetically sealed container to control the ingress of water vapor or other gases and to further assure the maintenance of sterility.

In use the sealing band 20 and the protective sheath 18 are removed. When used with a closed system intravenous con tainer as shown in FIG. 2, the piercing device 42 is inserted through a sealing member 52 and a rubber stopper 53 of the closed-system intravenous container 54. The conduit 44 provides communication between the interior of the container 54 and the contents of the dispensing package 10. Where the medicament 22 is a liquid, it is readily discharged into the container 54 by compressing the sides of the flexible container 12. The medicament 22 passes through the filter 16 where any particles are removed. The steps may be repeated to flush the container, if desired.

Where the medicament 22 is dry, the walls of the container 12 may be compressed and the tip 42 submerged in the liquid 56 by inverting the assembled system. A suitable portion of the liquid 56 may be drawn into the container 12 in order to dissolve the dry medicament. To make this possible it may be necessary to relieve any vacuum present. The reconstituted medicament solution may be discharged from the package 10 by compressing the sides of the container 12. The medicament 22 passes through the filter 16 where any particles are removed.

in FIG. 3 is shown the dispensing package 10 in position to discharge its contents into an open-system parenteral solution container 58. The outer surface 36 of the shank 32 engages the inner surface 60 of the container 58 and with it forms a tight seal. The tightness of the seal may be increased by the formation of a patterned configuration on the outer surface 36 of the shank 32 in order to develop a suitable friction seal. The medicament 22, when liquid, may be discharged directly into the container 58. Where the medicament is a solid, the package 10 and the parenteral solution container 58 may be inverted and a portion of the fluid 59 drawn into the dispensing package 10 where, with gentle agitation as necessary, it dissolves the medicament 22. The reconstituted medicament solution may be discharged by again returning the containers to the position shown in FIG. 3 and compressing the flexible sides of the container 12.

The container 12 is preferably made of polyethylene, or similar elastically recoverable material but may also be made of rigid material such as glass if desired. The cap 14 is preferably made of rigid polyethylene but may be made of any other suitable plastic or metal. The piercing device 42 is typically made of the same material as the remainder of the cap 14, but if desired may be ofa different material such as a metal or alloy. The protective sheath 18 or 19 and'stud 50 are typically plastic but may be made of rubber or other suitable materials. The seal band 20 may be made of metal or plastic, and preferably is a plastic that shrinks on drying.

The filter may be any suitable material, including sintered glass. However, membrane filters are preferred. Membrane filters are a class of thin filters composed of a porous matrix wherein the size of the pores prevents any insoluble matter larger than the pores from passing through the filter. When used for sterilization, membranes are composed of pores small enough to prevent the passage of microorganisms and thus render the solution sterile. The membrane filter is usually composed of cellulose esters such as cellulose acetate, cellu lose triacetate, cellulose nitrate, combination of cellulose acetate and nitrate, regenerated cellulose, polyethylene, nylon, Teflon, polyvinyl chloride, fluorinated vinyl, polypropylene, epoxy glass, acrylic vinyl copolymer, or the like. The membrane filters useful in the practice of the present invention customarily range in thickness from 25 to 300 microns and have a pore size range from about 0.005 micron to 10 microns, preferably from about 0.2 micron to 10 microns. The filter may assume a variety of designs and embodiments to accomplish its function. A preferred embodiment of the filter is one that resembles a plate-and-frame filter and comprises at least one membrane supported at its periphery. Filters having a pore size range of 0.005 to 10 microns are commercially available. Filters having pore sizes smaller than about 0.2 microns sterilize by removing micro-organisms. Filters having a pore size range of about 3 to ID microns are particularly useful in the preferred embodiment.

The terms and expressions which have been employed are used as terms of description and not oflimitation, and there is no intention in the use of such terms and expressions of excluding any equivalents of the features shown and described or portions thereof, but it is recognized that various modifications are possible within the scope of the invention claimed.

What I claim is: l. A dispensing package for medicaments to be added to a parenteral solution prior to parenteral administration comprising:

A. A reservoir adapted to contain a medicament; B. A conduit connected to said reservoir and adapted to convey said medicament from said reservoir to a parenteral solution container and having I. A piercing device forming one end of said conduit and adapted to pierce the closure of a closed-system parenteral solution container, and

2. A tapered shank means having a taper of predetermined size to sealably engage the inside of the neck of an open-system parenteral solution container of predetermined size;

C. Means to retain the medicament in said reservoir; and

D. Means to retain said reservoir, said retaining means and said conduit in abutting relation.

2. A package as defined in claim 1 wherein said reservoir is a variable volume reservoir.

3. A package as defined in claim 2 in which said piercing device is plastic.

4. A package as defined in claim 2 in which said piercing device is metal.

5. A package as defined in claim 2 in which said tapered shank has a patterned configuration defined in its outer surface.

6. A package as defined in claim 5 in which said patterned configuration is fluting.

7. A package as defined in claim 2 in which said retaining means is a membrane filter.

Claims (10)

1. A piercing device forming one end of said conduit and adapted to pierce the closure of a closed-system parenteral solution container, and
1. A dispensing package for medicaments to be added to a parenteral solution prior to parenteral administration comprising: A. A reservoir adapted to contain a medicament; B. A conduit connected to said reservoir and adapted to convey said medicament from said reservoir to a parenteral solution container and having
2. A tapered shank means having a taper of predetermined size to sealably engage the inside of the neck of an open-system parenteral solution container of predetermined size; C. Means to retain the medicament in said reservoir; and D. Means to retain said reservoir, said retaining means and said conduit in abutting relation.
2. A package as defined in claim 1 wherein said reservoir is a variable volume reservoir.
2. A tapered shank means having a taper of predetermined size to sealably engage the inside of the neck of an open-system parenteral solution container of predetermined size; C. Means to retain the medicament in said reservoir; and D. Means to retain said reservoir, said retaining means and said conduit in abutting relation.
3. A package as defined in claim 2 in which said piercing device is plastic.
4. A package as defined in claim 2 in which said piercing device is metal.
5. A package as defined in claim 2 in which said tapered shank has a patterned configuration defined in its outer surface.
6. A package as defined in claim 5 in which said patterned configuration is fluting.
7. A package as defined in claim 2 in which said retaining means is a membrane filter.
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Cited By (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3757779A (en) * 1971-05-24 1973-09-11 Century Labor Inc Filter syringe
US3868965A (en) * 1973-07-03 1975-03-04 United States Surgical Corp Drop former for intravenous set
US4076027A (en) * 1976-05-07 1978-02-28 Sherwood Medical Industries Inc. Fluid transfer device
US4128098A (en) * 1976-12-06 1978-12-05 American Hospital Supply Corporation Valved spike transfer device
US4250893A (en) * 1979-02-21 1981-02-17 American Hospital Supply Corporation Sample collection device
US4671330A (en) * 1984-10-26 1987-06-09 Gilbert Miles Container with removable transfer flask
DE3628197A1 (en) * 1986-08-20 1988-02-25 Streitenberg Hubert Dr Med Container for liquid medicaments
US4986322A (en) * 1987-03-24 1991-01-22 Societe Semco System of packaging for ready to use preparations
US5105993A (en) * 1989-12-29 1992-04-21 La Haye Laboratories, Inc. Disposable medical dispenser with a filtering dispenser nozzle
US5286453A (en) * 1992-04-02 1994-02-15 Pope Carolyn M Device for dispensing a biological fluid from a sealed vacuum tube
WO1995030594A1 (en) * 1994-05-10 1995-11-16 Rathor Ag Push-on cleaning bottle
US5536413A (en) * 1990-12-03 1996-07-16 Pall Corporation Method for treating a parenteral emulsion-containing medicament fluid
US5567322A (en) * 1995-09-13 1996-10-22 Rundle; Christopher Water cooler filtration device
US5954957A (en) * 1995-07-03 1999-09-21 Althin Medical, Inc. Multi-purpose cap for hydraulic ports on a medical device
US6405765B1 (en) * 1998-12-21 2002-06-18 Rickie Michael Handrick Fluid recovery device with pivoting nozzle
US20020193732A1 (en) * 2001-06-19 2002-12-19 Wendy Naimark Method and apparatus to modify a fluid using a selectively permeable membrane
WO2003086268A1 (en) * 2002-04-11 2003-10-23 Pharmacia Corporation File ampoule system
US6652509B1 (en) 2000-04-03 2003-11-25 Abbott Laboratories Housing capable of connecting a container to a medical device
US20040138611A1 (en) * 2000-10-10 2004-07-15 Meridian Medical Technologies, Inc. Wet/dry automatic injector assembly
US20040140285A1 (en) * 2001-06-01 2004-07-22 Vetter Udo J. Sealing element
US6779566B2 (en) 2003-01-14 2004-08-24 Access Business Group International Llc Connector device for sealing and dispensing freeze-dried preparations
US20040254543A1 (en) * 2000-10-10 2004-12-16 Griffiths Steven M. Needle and hub assembly for automatic injector
US20070233020A1 (en) * 2006-03-30 2007-10-04 Isaac Hearne Cannula tip eye drop dispenser
US20080015539A1 (en) * 2006-02-28 2008-01-17 Robert Pieroni Bottle with adapter for receiving needleless syringe
US20080281271A1 (en) * 2007-05-09 2008-11-13 Griffiths Steven M Drug delivery system with a small amount of a therapeutic agent
US20110022023A1 (en) * 2008-01-09 2011-01-27 Novartis Ag Unitary withdrawal spike unit suitable for factory fitting
US20110053869A1 (en) * 2008-01-25 2011-03-03 Foker John E Methods and compositions for inhibiting progression to chronic cardiac failure
US20120305607A1 (en) * 2010-04-12 2012-12-06 Andreas Geiger One-way valve for discharge regulation in tubes, tube with such a one-way valve and method for manufacturing such a one-way valve
US20130008561A1 (en) * 2010-02-08 2013-01-10 Fresenius Kabi Deutschland Gmbh Connector for a container including a medicinal active ingredient
US20150034677A1 (en) * 2013-07-31 2015-02-05 Op-Hygiene Ip Gmbh Dispenser Shroud
US20160023804A1 (en) * 2014-07-28 2016-01-28 Automatic Bar Controls, Inc. Corks for use with wireless spouts
US20160037975A1 (en) * 2014-08-06 2016-02-11 Russell M. Rice Multi-Fit, Fast Connect, Dispenser to Bottle 8 Connection Kit for Liquid Dispensers

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US729835A (en) * 1902-10-03 1903-06-02 George S Barnes Bottle-stopper.
US1903915A (en) * 1932-05-27 1933-04-18 Smith Ramsey Pipe cleaning device
GB527109A (en) * 1939-03-31 1940-10-02 William Simon Freeman Improvements in or relating to stoppers or caps primarily for bottles, jars, carboys and other containers
US2778360A (en) * 1955-05-09 1957-01-22 Pfizer & Co C Hypodermic syringe
US2854977A (en) * 1956-06-15 1958-10-07 Mine Safety Appliances Co Mixing and dispensing device
US2957501A (en) * 1958-08-25 1960-10-25 Burroughs Wellcome Co Device for dispensing muscle relaxant drugs
US2957609A (en) * 1958-11-06 1960-10-25 Burroughs Wellcome Co Device for dispensing muscle relaxant drugs
US3307552A (en) * 1963-03-25 1967-03-07 Lillian T Strawn Catheter plug and shield device
US3207374A (en) * 1963-11-14 1965-09-21 Burroughs Wellcome Co Dispenser
US3434636A (en) * 1967-05-16 1969-03-25 Robert D Kachman Pourer for liquor bottles

Cited By (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3757779A (en) * 1971-05-24 1973-09-11 Century Labor Inc Filter syringe
US3868965A (en) * 1973-07-03 1975-03-04 United States Surgical Corp Drop former for intravenous set
US4076027A (en) * 1976-05-07 1978-02-28 Sherwood Medical Industries Inc. Fluid transfer device
US4128098A (en) * 1976-12-06 1978-12-05 American Hospital Supply Corporation Valved spike transfer device
US4250893A (en) * 1979-02-21 1981-02-17 American Hospital Supply Corporation Sample collection device
US4671330A (en) * 1984-10-26 1987-06-09 Gilbert Miles Container with removable transfer flask
DE3628197A1 (en) * 1986-08-20 1988-02-25 Streitenberg Hubert Dr Med Container for liquid medicaments
US4986322A (en) * 1987-03-24 1991-01-22 Societe Semco System of packaging for ready to use preparations
US5105993A (en) * 1989-12-29 1992-04-21 La Haye Laboratories, Inc. Disposable medical dispenser with a filtering dispenser nozzle
US5536413A (en) * 1990-12-03 1996-07-16 Pall Corporation Method for treating a parenteral emulsion-containing medicament fluid
US5286453A (en) * 1992-04-02 1994-02-15 Pope Carolyn M Device for dispensing a biological fluid from a sealed vacuum tube
WO1995030594A1 (en) * 1994-05-10 1995-11-16 Rathor Ag Push-on cleaning bottle
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