US2677373A - Plastic injection device - Google Patents

Plastic injection device Download PDF

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Publication number
US2677373A
US2677373A US288723A US28872352A US2677373A US 2677373 A US2677373 A US 2677373A US 288723 A US288723 A US 288723A US 28872352 A US28872352 A US 28872352A US 2677373 A US2677373 A US 2677373A
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Prior art keywords
hub
needle
hood
body portion
neck
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US288723A
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Barradas George
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P M IND Inc
P M INDUSTRIES Inc
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P M IND Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/281—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule
    • A61M5/282—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule by compression of deformable ampoule or carpule wall
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/285—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened
    • A61M5/288—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened by piercing without internal pressure increase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3202—Devices for protection of the needle before use, e.g. caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/50—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile
    • A61M5/5086—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile for indicating if defective, used, tampered with or unsterile

Definitions

  • This invention relates to hypodermic injection devices, particularly to hypodermic devices that are adapted to be furnished filled and sealed as sterile units to be stored until used, containing such substances as medicines, antitoxins, opiates and the like, so that these substances can be quickly and efficiently administered.
  • the present invention comprises a body portion made of a soft, pliable plastic material, that would be compatible with the medical solution, such as polyethylene, having a neck on one end thereof and being filled and heat sealed at the other end thereof and this neck being provided with an axial conduit therein and a diaphragm Within this conduit to retain the contents of the tube until such a time as it is desired to use the same.
  • the neck is also covered with a thin material to retain the same in a sterile condition.
  • cover may be aluminum foil, Saran film or Cel-O-Seal.
  • the needle portion containing a needle cast in a methacrylate hub is covered and protected by a polystyrene hood. This assembly is also protected by the same means as is the body portion.
  • Figure l is a sectional view showing the body portion and the needle portion before assembly
  • Figure 2 is a sectional view showing the body portion and the needle portion partially assembled
  • Figure 3 is a sectional view showing the body portion assembled and the hood released ready for removal.
  • Figure 4 is a sectional view on line 44 of Fig. 2.
  • Figure 5 is a plan view of the assembled device ready for shipping.
  • Figure 6 is a plan view of an alternative method of assembling the device.
  • Figure 7 is a sectional view of the assembled device as shown in Figure 6.
  • the body portion 10, shown in Fig. 1 is sealed at end I 1 thereof after the contents have been introduced.
  • This body portion has a neck 2 in the upper end thereof, this neck having conduits l3 and I4 separated by the diaphragm l5.
  • This neck on' the body portion is made of the same material as the body portion and may have no thread molded thereon, but is capable of being assem bled into the threaded part of the hub of the Fig. 4 iit into their grooves in the hub and hold the same in position, thereby causing the hub to rotate when the head is rotated.
  • This hood 6 is long enough to completely enclose the needle and the hub within the hood and will have a free space i 8 between the bottom of the hub and the bottom of the hood. The purpose of this free space will become apparent when the meth- 0d of assembly is described.
  • the hood itself is made of any type of material, preferably of a thermoplastic nature such as polystyrene.
  • the hub i9 is molded from a harder material than the body portion it, such a material being methacrylate resin.
  • This hub portion is molded so as to contain the threaded conduit or bore 20, at the base thereof and having a double ended needle 2
  • the hood and base referred to above are molded so that the tongue is on the head and the corresponding groove is in the base. It may be desirable to reverse these parts and have the tongue on the base and the corresponding groove in the head and this invention should therefore not be limited by the position of the various parts.
  • This invention includes any method of rotating the hood and hub together by means of interlocking parts and should not be limited to the tongue I! and the corresponding groove.
  • -' hood is assembled with the base so as to cover the needle as shown in Fig. 1. This is then sterilized and its open end sealed by means of a seal of the type which may be removed just prior to use. This is shown in Fig. 5.
  • An alternative method is to sterilize the body portion and the needle portion and partially assemble the same as shown in Figs. 6 and 7 wherein the hub 19 is partially fastened on to the neck I 2 and the open space between the shoulder 23 and the end of the hub 22 as shown in Figure 7 is sealed by means of a removable seal 24 shown in Figs. 6 and 7.
  • removable seals are of a foil type such as aluminum foil, tin foil, or a film type such as Saran or Cel-O-Seal" but it is clear that any thin removable material may be used to seal these openings to maintain them in a sterile condition until such a time as it is desired to completely assemble .the parts for: use:v
  • a hypodermic injection device comprising a body portion coznbined with'a needle :portion detachably secured 'to said needle portion;: the said body portlom-having-"a; neck containing 2.1 central conduit and a diaphragm sealing 'the' latter; said needle portiorrcomprising a hub h'av ing an axially threaded recess engaging"! and cutting threads" on: the exterion of said n'eckS'cn the body portion, said hubhavin'g'a double 'endedi needle molded therein w-ith 'one end of: the needle in said threaded recess, 1 said hub being :composed:
  • a hypodermic injection device fcomprising -a polyethylene bodyportiorr'combined with ain'eedle" portion detachably secured to said needle portion;
  • said needle portion comprising a methacrylate- I hub having an axially threaded recess 5 engaging and scutting' threadsonJthe exterior aof sa-idrneck on the-body portion; said- 'hub having a double ended needle' cast-therein with'rone en'di'ofiith'e needle in said threaded recess, and a polystyrene hood enclosing the portion of the needle projecting beyond said hub, said hub having at least one tongue force fitted into corresponding grooves in said hub, the end of the hood projecting beyond said hub being engageable with the body portion, when the hub is screwed thereon, before the "end bf [thefhub is seated pnzthb body portion, and 'sa-icl *hoodbeing relased whenihe
  • a hypodermic injection device comprising a-.-body.-portion combined with a needle portion detachably secured to said needle portion, the said .body portion having a neck containing a centz-atcondiiit'arid a diaphragm sealing the latter, said needle portion comprising a hub having an axiallymhreaded recess engaging and cutting threads on the exterior of said neck on the body portion'g said hub having a double ended needle cast therein with one end of the needle in said threadedzrecessn saidaihubbbeingfrcomposedioffa hardersvmaterial:thanztheneckipart of itherbodyi portiomiand" aahoo d'enclosing :th'eeportionz'of the' needleeprojecting-rrbeyond .1 said shub; the 'em'l v2 of' the thcod'tprojecting beyondasaidihubz being: en's gagea'ble :wit
  • a hypodermic injection device ecomprising a collapsible tube of relatively soft material have ing a :necktclosed :byi azr-readily "pierceablerzdiaphragm"; .in 1 combinatio llwithji a: hub zhaving a 1 7 bore"partiallyi mnuntedcjon: said-aineckg theebore' Ofi'thG ":hubsbeing internallyrthreadedd .an'da'saicl huba: being r ofi.
  • a hypodermic injection device comprising hood conformin with theirhnb so that on axial rotation of then hoodzithe r'hubn also rotates; in
  • a hypodermic needle component adapted for association with a collapsible tube having a neck closed by a readily pierceable diaphragm, essentially comprising a hub having an internally-threaded bore, a double-pointed needle fixed in the hub with one point spaced from the hub and the other projecting into the bore of said hub, and a hood slidably mounted on the hub and enclosing the spaced point of the needle, the inside of the hood conforming with the hub so that on axial rotation of the hood the hub also rotates.
  • hypodermic needle component defined by claim 7, in which the end of the hood extends beyond the end of the hub.

Description

G- BLRRADAS 2 Sheets-Sheet l May 4, 1954 PLASTIC INJECTION DEVICE Filed May 19, 1952 S W A w m R V R m A B F. G m B m m \\\\\\\\\\\\\\\V\\\\\\\\\\\\\\\\\ w A M 5 .4. l m F V 4 9 a m n 4 G PM W O May 4, 1954 e. BARRADAS PLASTICi INJECTION DEVICE Filed May 19, 1952 2 Sheets-Sheet 2 FIG] 19 STE me 24 5 3 ,32? Z4 Z2 L I? 'EXLIIK/EET I 24 cEL-o-sEAL" bri I I I l ATTORNEY Patented May 4, 1954 UNITED STATES PLASTIC INJECTION DEVICE George Barradas, North Tarrytown, N. Y., assignor to P M Industries, Incorporated, Stamford, Conn.
Application May 19, 1952, Serial No. 288,723
8 Claims.
This invention relates to hypodermic injection devices, particularly to hypodermic devices that are adapted to be furnished filled and sealed as sterile units to be stored until used, containing such substances as medicines, antitoxins, opiates and the like, so that these substances can be quickly and efficiently administered.
It is an object of this invention to provide a unit containing a single dose of the medicine sealed within a plastic container, said unit being sterilized and maintained in a sterile condition.
It is a further object of this invention to supply a needle assembly that is sterilized and maintained in a sterile condition, such that the needle assembly may be readily attached to the body portion in such a manner that there will be no possibility of thread discrepancies.
The present invention comprises a body portion made of a soft, pliable plastic material, that would be compatible with the medical solution, such as polyethylene, having a neck on one end thereof and being filled and heat sealed at the other end thereof and this neck being provided with an axial conduit therein and a diaphragm Within this conduit to retain the contents of the tube until such a time as it is desired to use the same. The neck is also covered with a thin material to retain the same in a sterile condition. Such cover may be aluminum foil, Saran film or Cel-O-Seal.
The needle portion containing a needle cast in a methacrylate hub is covered and protected by a polystyrene hood. This assembly is also protected by the same means as is the body portion.
The invention will be described in detail in connection with the accompanying drawings wherein:
Figure l is a sectional view showing the body portion and the needle portion before assembly;
Figure 2 is a sectional view showing the body portion and the needle portion partially assembled;
Figure 3 is a sectional view showing the body portion assembled and the hood released ready for removal.
Figure 4 is a sectional view on line 44 of Fig. 2.
Figure 5 is a plan view of the assembled device ready for shipping.
Figure 6 is a plan view of an alternative method of assembling the device.
Figure 7 is a sectional view of the assembled device as shown in Figure 6.
Referring to the drawings, the body portion 10, shown in Fig. 1 is sealed at end I 1 thereof after the contents have been introduced. This body portion has a neck 2 in the upper end thereof, this neck having conduits l3 and I4 separated by the diaphragm l5. This neck on' the body portion is made of the same material as the body portion and may have no thread molded thereon, but is capable of being assem bled into the threaded part of the hub of the Fig. 4 iit into their grooves in the hub and hold the same in position, thereby causing the hub to rotate when the head is rotated. This hood 6 is long enough to completely enclose the needle and the hub within the hood and will have a free space i 8 between the bottom of the hub and the bottom of the hood. The purpose of this free space will become apparent when the meth- 0d of assembly is described. The hood itself is made of any type of material, preferably of a thermoplastic nature such as polystyrene. The hub i9 is molded from a harder material than the body portion it, such a material being methacrylate resin. This hub portion is molded so as to contain the threaded conduit or bore 20, at the base thereof and having a double ended needle 2| molded therein with the short end of the needle projecting into the threaded portion of the base and the long end of the needle spaced from the hub and having grooves in the sides thereof to take the tongue molded on the hood. The hood and base referred to above are molded so that the tongue is on the head and the corresponding groove is in the base. It may be desirable to reverse these parts and have the tongue on the base and the corresponding groove in the head and this invention should therefore not be limited by the position of the various parts. This invention includes any method of rotating the hood and hub together by means of interlocking parts and should not be limited to the tongue I! and the corresponding groove. The
-' hood is assembled with the base so as to cover the needle as shown in Fig. 1. This is then sterilized and its open end sealed by means of a seal of the type which may be removed just prior to use. This is shown in Fig. 5. An alternative method is to sterilize the body portion and the needle portion and partially assemble the same as shown in Figs. 6 and 7 wherein the hub 19 is partially fastened on to the neck I 2 and the open space between the shoulder 23 and the end of the hub 22 as shown in Figure 7 is sealed by means of a removable seal 24 shown in Figs. 6 and 7. These removable seals are of a foil type such as aluminum foil, tin foil, or a film type such as Saran or Cel-O-Seal" but it is clear that any thin removable material may be used to seal these openings to maintain them in a sterile condition until such a time as it is desired to completely assemble .the parts for: use:v
The method of assembling this apparatus com prises the removal of the seals on the needle portion and the body portion, the introduction of the neck [2 of the body portion=-into the: threaded recess 20 of the needle portion and rotating one assembly relative to the other in suohxa manner that the threaded recesswil1 c11t-fi threads on the neck and the short end of the needle will pierce the diaphragm-M5 .as=show-n in Fig. 2. When the end of the hood 22 comes in contact with the shoulder 23 of the bodsrpor tion the threads will then have at least one or more'izturns =to-izmake'ronethe:necl: of ,thee'bodyl' portion:w This allows theegap lBIShOWIlEliIl Figs 1 anda12 "between? the hubsl 9: and the-tshouldei" of the :body :portion: Then: thevhoodxiand-rthe hub I 9 :ane' rrotated .through'. :one or :inorentums sozrthatitheihubolfl is-seatecl on the shoulder :23 of the :body portion; Thechoodril 6 is forcedum wardly'i our the Fhllbl and: the; flanges: I I; I1 fare looseneddin: their respective rgrooves; This will? allow the ready 'remova'li lot :the hood: fronr the assembly which is '-;then ready for rusex While in: the above examples the.--:hubi'portion:' is madefof harder: material and contains; the" thread," it is within theiiscope"of' :this; invention' to have the neck portion made tof ra -harder" ma= terial than the -hub portion :in: which case rtheneck portion: 'is-moI'ded ZWith the fthread on 'the. exterior surface thereof i While theiabove' examples are given' for' pure poses ofillustration; many variations 'of this in= venticnare readily seen'by 'a person' skilled thearti- What is claimd is:
1. A hypodermic injection device comprising a body portion coznbined with'a needle :portion detachably secured 'to said needle portion;: the said body portlom-having-"a; neck containing 2.1 central conduit and a diaphragm sealing 'the' latter; said needle portiorrcomprising a hub h'av ing an axially threaded recess engaging"! and cutting threads" on: the exterion of said n'eckS'cn the body portion, said hubhavin'g'a double 'endedi needle molded therein w-ith 'one end of: the needle in said threaded recess, 1 said hub being :composed:
of aharde'r' material than the-neck part ofthe:
body portion, anda hood enclosing the portionof the needle =projecting beyond 'said- 'hubf;- said 1 hood-having at least one tongue force -fittedtinto: corresponding"grooves-=in -.saidhub; the rend": of; the-hood "projecting beyond 'the bottom o-f' said' hub being engageable with the. body: portion; when the hub "is" screwed thereon; before -bottcmz' eithe -hub is seated on thebody portion; and-isaidci hood being releascd when the 'hub is' seated on the body portion;
2: A hypodermic injection device fcomprising -a polyethylene bodyportiorr'combined with ain'eedle" portion detachably secured to said needle portion;
the'said body portionh'aving a neck? containing a central- 'conduit and' adiaphragm sealihg :the lat ter, said needle portion comprising a methacrylate- I hub having an axially threaded recess 5 engaging and scutting' threadsonJthe exterior aof sa-idrneck on the-body portion; said- 'hub having a double ended needle' cast-therein with'rone en'di'ofiith'e needle in said threaded recess, and a polystyrene hood enclosing the portion of the needle projecting beyond said hub, said hub having at least one tongue force fitted into corresponding grooves in said hub, the end of the hood projecting beyond said hub being engageable with the body portion, when the hub is screwed thereon, before the "end bf [thefhub is seated pnzthb body portion, and 'sa-icl *hoodbeing relased whenihe hub is seated on the body portion.
3. A hypodermic injection device comprising a-.-body.-portion combined with a needle portion detachably secured to said needle portion, the said .body portion having a neck containing a centz-atcondiiit'arid a diaphragm sealing the latter, said needle portion comprising a hub having an axiallymhreaded recess engaging and cutting threads on the exterior of said neck on the body portion'g said hub having a double ended needle cast therein with one end of the needle in said threadedzrecessn saidaihubbbeingfrcomposedioffa hardersvmaterial:thanztheneckipart of itherbodyi portiomiand" aahoo d'enclosing :th'eeportionz'of the' needleeprojecting-rrbeyond .1 said shub; the 'em'l v2 of' the thcod'tprojecting beyondasaidihubz being: en's gagea'ble :wit-hxzthe bodyrportion; Whell'llthEhI-hllb is screwedrthereon; beioreethe 'cendiof rthei hubris. seated" on'rthe bodyrportiongzand isaid'hood Fbeifig reieased when the hubziaseated-tonzthe body port-i tion.
4. A hypodermic injection: device ecomprising a collapsible tube of relatively soft material have ing a :necktclosed :byi azr-readily "pierceablerzdiaphragm"; .in 1 combinatio llwithji a: hub zhaving a 1 7 bore"partiallyi mnuntedcjon: said-aineckg theebore' Ofi'thG ":hubsbeing internallyrthreadedd .an'da'saicl huba: being r ofi. relatively" harden material and adapted to cut threadsron the meck of the tube when axially rotated 'rwitharespeciz 'tocthe rztube andilthereby beccming fizreadily-assemblcd there 4 on :v a double pointedzneedle fixed inithe hubfw-ith one pointispaced from'sth'echubr andithe other projecting-into theabore of-Saidchlib and: aihood' slidably: mounted-Son: the huband' encldsingzthe spacedipoint ofthe'needl.
5; Ahypodermindnjectiom device comprising collapsible tube havingi a neck-closed by a readilypierceable diaphragm;in'combinatiorr with a-hub havingsa *bore partially mounted ion-"said: neck, the 'hub and-neck being adaptecl to *becom'e rigid- I 1y assembled on relative axial rotation*, a=double-'- pointed needle fixed in' the hub-with'one point spaced 'from the hub and the other projectirig into "the bore totsaid hub; and-"a'hbod "sli'dably mounted on the and' enclosing "the spaced point of the needle; the inside of "the 'hood'conforming-With the *h'ub so that on axial rotation of the hood the hub also rotates, in which the" hue-and" collapsible tube are -=bridged by 'a removable sealing materi'al adapted. to exclddc' contaminants 'and"prevent relative axial rotation ofthe'hoodand tubey- 6. A hypodermic injection device comprising hood conformin with theirhnb so that on axial rotation of then hoodzithe r'hubn also rotates; in
which the hood extends beyond the end of the hub, said hood end contacting the tube on rotation before the hub and the neck become rigidly assembled.
7. A hypodermic needle component adapted for association with a collapsible tube having a neck closed by a readily pierceable diaphragm, essentially comprising a hub having an internally-threaded bore, a double-pointed needle fixed in the hub with one point spaced from the hub and the other projecting into the bore of said hub, and a hood slidably mounted on the hub and enclosing the spaced point of the needle, the inside of the hood conforming with the hub so that on axial rotation of the hood the hub also rotates.
8. The hypodermic needle component defined by claim 7, in which the end of the hood extends beyond the end of the hub.
References Cited in the file of this patent UNITED STATES PATENTS Number Number 15 117,415
Name Date Fitting Sept. 24, 1918 Marcy Jan. 6', 1925 Anthony July 10, 1928 Marcy Oct. 16, 1928 Everett July 8, 1947 Safiir June 20, 1950 Hart Nov. 4, 1952 Lockhart Jan. 13, 1953 FOREIGN PATENTS Country Date Australia Sept. 15, 1942
US288723A 1952-05-19 1952-05-19 Plastic injection device Expired - Lifetime US2677373A (en)

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DE1064692B (en) * 1955-11-04 1959-09-03 Hoechst Ag Cannula equipment for injection ampoules u. like
US2953243A (en) * 1957-07-25 1960-09-20 Roehr Zbislaw Maciej Disposable needle assembly
US3008570A (en) * 1960-03-30 1961-11-14 Brunswick Corp Ejector package
US3021942A (en) * 1957-06-27 1962-02-20 Baxter Don Inc Needle package
US3036700A (en) * 1959-08-26 1962-05-29 Becton Dickinson Co Sterile hypodermic needle assembly and package
US3043304A (en) * 1959-03-30 1962-07-10 Brunswick Corp Hypodermic needle mount
US3072120A (en) * 1960-03-30 1963-01-08 Brunswick Corp Card-supporting hypodermic syringe
US3074542A (en) * 1960-01-06 1963-01-22 Myerson Tooth Corp Package for hypodermic needles
US3095972A (en) * 1961-10-06 1963-07-02 James L Sorenson Self-sealing sterile packaging and method
US3130724A (en) * 1962-05-07 1964-04-28 Roehr Products Company Inc Syringe structure
US3166070A (en) * 1961-12-05 1965-01-19 Lapis Engineering Company Ltd Syringe for hypodermic injection
US3294089A (en) * 1960-12-14 1966-12-27 Richard A Brookfield Hypodermic needle
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US3504826A (en) * 1968-05-16 1970-04-07 Ewell Lee Carlton Sealant containers and dispensers
US3677247A (en) * 1970-12-03 1972-07-18 Sherwood Medical Ind Inc Needle cap for syringe package
US3825002A (en) * 1972-02-07 1974-07-23 Amalgamated Dental Co Ltd Cartridge syringe and crimped needle assembly
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US3908638A (en) * 1972-06-14 1975-09-30 Burroughs Wellcome Co Blood sampling device
US4240427A (en) * 1978-10-23 1980-12-23 American Hospital Supply Corporation Needle with protector
US4296786A (en) * 1979-09-28 1981-10-27 The West Company Transfer device for use in mixing a primary solution and a secondary or additive substance
US4927019A (en) * 1989-06-12 1990-05-22 Habley Medical Technology Corporation Combination needle sheath and sterility package
US4955871A (en) * 1987-04-29 1990-09-11 Path Single-use disposable syringe
US5405340A (en) * 1992-10-07 1995-04-11 Abbott Laboratories Threaded securing apparatus for flow connectors
US5547131A (en) * 1992-12-04 1996-08-20 Bespak Plc Dispensing device with spray nozzle and driven piston
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US20020121139A1 (en) * 2001-03-02 2002-09-05 Purpura Paul E. Adapter for holding a sample container to facilitate sensing of liquid level in the sample container
US20070118083A1 (en) * 2002-12-26 2007-05-24 Bradley Pharmaceuticals, Inc. Method and apparatus for dispensing a composition
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