US3378008A - Hypodermic syringe with vial - Google Patents

Hypodermic syringe with vial Download PDF

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Publication number
US3378008A
US3378008A US47441365A US3378008A US 3378008 A US3378008 A US 3378008A US 47441365 A US47441365 A US 47441365A US 3378008 A US3378008 A US 3378008A
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Prior art keywords
vial
plug
holder
needle
end
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Expired - Lifetime
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Robert W Ogle
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MIN I JET CORP
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MIN I JET CORP
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Priority to US47441365 priority Critical patent/US3378008A/en
Application filed by MIN I JET CORP filed Critical MIN I JET CORP
Priority to US55129166 priority patent/US3376866A/en
Priority claimed from DE19661766675 external-priority patent/DE1766675A1/en
Priority claimed from FR70035A external-priority patent/FR1487084A/en
Priority claimed from GB3268966A external-priority patent/GB1159663A/en
Priority claimed from CH1362668A external-priority patent/CH475758A/en
Priority claimed from ES0329382A external-priority patent/ES329382A1/en
Priority claimed from FR91537A external-priority patent/FR1527787A/en
Priority claimed from BE693002D external-priority patent/BE693002A/fr
Priority to AU1676467A priority patent/AU420855B2/xx
Application granted granted Critical
Publication of US3378008A publication Critical patent/US3378008A/en
Anticipated expiration legal-status Critical
Application status is Expired - Lifetime legal-status Critical

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/24Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2422Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule
    • A61M5/2429Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule by telescoping of ampoules or carpules with the syringe body

Description

April 16, 1968 R. w. OGLE HYPODERMIC SYRINGE WITH VIAL 2 Sheets-Sheet l FIG.6

Filed July 23,- 1965 FIG.5

FIGA

FIG.\

R O T N E V W ^//7// V1 vi; @fil Uf Il 2 6 M 6% 6 5 4 6 4 2 i N///MV/l//f/ w 2 i.- I e f G Z I H h//f/// BY M H TJ/YE/ April 16, 1968 R. w. OGLE HYPODERMIC SYRINGE WITH VIAL 2 Sheets-Sheet r,

Filed July 23, 1965 FIGB INVENTOR POSE/P7 VK OGLE United States Patent O 3,378,098 HYPODERMIC SYRINGE WITH VIAL Robert W. Ggle, Phoenix, Ariz., assigner to Min-Liet Corporation, Wilmington, Del., a corporation of Delaware Filed July 23, 1965, Ser. No. 474,413 Claims. (Cl. 12S-220) ABSTRACT OF THE BISCLOSURE A medicament injector comprising a cylindrical vial having an open end and a closed end and a resilient plug adapted to be inserted partially into said open end of said vail. A plurality of outwardly extending rings upon said plug engage the walis of said vial with a press fit. A cylindrical holder has an open end and a closed end and a cylindrical member within and spaced from said holder has one end engaging said closed end of said holder. The cylindrical member extends longitudinally of said holder and terminates at an open end within said holder. The holder has a needle extending outwardly from said holder and also inwardly into said holder within said cylindrical member and has a sharpened inner end. Interlocking means are on said cylindrical member and cooperating interlocking means are on said plug whereby upon insertion of said plug into said holder said vial is first held in an assembled but non-operating position and upon further insertion of said plug into said holder said plug is pierced by said needle and said needle communicates with said vial and said plug is locked securely in said cylindrical member to permit aspiration upon withdrawal of said vial or to permit expulsion of the contents of said vial upon exertion of pressure of said vial.

This invention relates to a combination package, vial and injector, and though it has sometimes been referred to in this art as a syringe, we .prefer to distinguish from a syringe in this invention in that a syringe ordinarily consists of a barrel which contains an injectable fluid and a plunger which propels the uid from the barrel, whereas in this invention the container for the uid also acts as a propeller or propelling agent for the iiuid and thus differs from the hypodermic syringe. However, it is noted in prior art and particularly those patents to Lockhart such as Lockhart 2,490,447 and 2,5 86,069, that this general type of injector is nevertheless termed a syringe.

It is a feature of this invention that the vial portion which contains the injectable fluid forms a separate element which may be removed from the combination filled with the desired injectable fluid with conventional filling machines, sealed with the sealing mechanism hereinafter described and then combined with the remainder of the injector to form the overall injector and/ or syringe.

It is a further feature of this invention that after the vial has been loaded and sealed as heretofore mentioned it may be combined with the barrel of the injector for storage without in any way communicating the contents of the iiuid to the barrel of the injector until precisely at the point when it is desired to use the injector.

It is a further feature of this invention that sure, positive and always effective means not relying upon mere friction are present, which enable the user i.e the physician or nurse, to aspirate the injector positively in all cases so as to prevent the injection of the medicament directly into a vital portion of the body, such as a vein, artery or organ, unless so desired.

It is a further feature of this invention that the needle of the injector in the portion extending within the injector terminates short of the surrounding cylindrical portion rather than extending at any time beyond said cylindrical Mice portion with the result that the tip of said portion of said needle is protected at all times from accidental contact which might in some manner injure or render ineffective this end of the needle.

It is a further feature of this invention that whereas said needle referred to above is at all times short of the surrounding cylindrical portion, it assures that the puncturing of the rubber stopper as hereinafter described is directed centrally thus avoiding any possibility of the needle puncturing a side of said stopper and rendering the device ineffective.

It is a further feature of this invention that the glass vial at its open end in all embodiments of this invention is reduced in diameter so that when the physician or nurse aspirates, the necked-over edge of the vial will contact the innermost rings of the stopper and provide a warning for, or actually prevents, the physician or nurse from inadvertently removing the vial from the stopper thus expelling the contents on the floor.

These and other objects, features and advantages will be apparent from the annexed specifications in which:

FIGURE 1 is a plan View of a package embodying the present invention as presented for distribution in its most preferred embodiment;

FIGURE 2 is a section taken along line 22 of FIG- URE 1;

FIGURE 3 is a section taken along line 3 3 of FIG- URE 4;

FIGURE 4 is a vertical section of an injector embodyine a preliminary form 0f this invention;

FIGURE 5 is a section similar to FIGURE 4 showing the first step in the use of the device shown in FIG- URE 4;

FIGURE 6 is a View similar to FIGURES 4 and 5 showing the condition of the embodiment of these figures in its final condition when the medicament has been injected into the patient;

FIGURE 7 is a vertical section similar to FIGURES 4, 5 and 6 of a second preliminary embodiment of this invention;

FIGURE 8 is a vertical section of the preferred ernbodiment of this invention which preferred embodiment is intended to be housed in the housing shown in FIG- URES l and 2 and is further illustrated as contained in said housing in FIGURE 2; and

FIGURE 9 is a fragmentary section similar to FIGURE 8 showing a different embodiment of the needle sealing means.

Referring now more particularly to the drawings and particularly to the preferred embodiment shown in FIGURE 8, the device is shown comprisng a vial 2G preferably in the form of a glass or plastic cylinder having an outer flange 21 of a closed end 22 and an open end 23. The walls of the open end 23 are necked-over as at 24 for a purpose hereinafter described.

A resilient plug 2S is provided having a central bore 26 extending only part-way through the plug as clearly indicated in FIGURE 8. The plug 2S has a reduced section 27 provided with male threads 28 and an enlarged section 29 provided with outstanding rings 3o, 31 and 32. The vial 20 may be placed in an ordinary filling machine as commonly used by pharmaceutical manufacturers and filled with a liquid injectable. Thereafter the plug 25 may be inserted in the vial 2G to the extent that all three of the rings 3i), 3i and 32 are contained within the vial and the outer ring 32 is within the necked-over end walls 24. It will thus 'be seen that the vial 2i) with the plug 25 constitutes a self-contained unit in which the medicament may be sealed in a sterile condition. A holder 33 formed of glass or suitable plastic is provided which is generally cylindrical in form and has formed therein a second cylindrical member 34. The holder 33 is provided with an outwardly extending flange 35 at its end. The cylindrical member 34 terminates at a point 36 well within the open end of the holder 33 as clearly indicated. The interior of the cylindrical member 34 adjacent its outer end is provided with a series of female threads 37 adapted to mate with male threads 28 of the plug 25. The threads as just described engage with a loose lit so as to prevent substantially no frictional resistance to the making up of the threads and certainly insufcient resistance to overcome the press tit of the rings 30, 31 and 32 within the vial 20. The holder 33 is provided with a closed end 38 and an outwardly extending boss 39 having a bore 4i) therein in which is securely cemented, as by an epoxy cement, a needle 41 which has an inwardly extending sharpened end 42 and an outwardly end 43 sharpened in the fashion of a conventional syringe cannula.

In use, assuming the vial 28 to be filled with the injectable fluid 44 enclosed with the plug 25, the vial 2t) having the plug secured therein with all three of the rings 30, 31 and 32 being inside, the necked-over end 24 is taken and inserted into the holder 33 such that the male threads 28 mate with the female threads 37 of the cylindrical member 34. This is the condition of the mechanism as shown in FIGURE 8.

In the condition shown in FIGURE 8 the device above described is taken and placed in the housing shown-in FiGURES 1 and 2. This housing comprises of an upper cylindrical casing 45 and a lower cap 46 both of which have closed ends. The wall of the cap 46 is reduced as at 47 to form a shoulder 48 upon which the casing 45 may -be seated and sealed with a press tit. It will be apparent that with a sterile seal at the point 4S the entire device as shown in FIGURE 8 is a sterile package contained in its sterile housing. The casing 45 is provided with a plurality inwardly extending ribs 49 which extend downwardly Vto a portion 50 at which point the ribs 49 are of reduced width as shown at 51 forming a shoulder 52 against which the end wall 38 of the holder 33 seats when contained in the package and prevents the end 43 of the needle from striking the end of the casing 45. T he reduced portion 47 of the cap 46 extends upwardly and provides a stop by engaging the flange 35 of the holder 33 thus securely holding the device between the two stops formed 'by the shoulder 50 and the reduced portion 47.

When it is desired to use the device of the preferred embodiment above described the casing 45 and cap 46 are removed. The device shown in FIGURE 8 is then taken with the holder 33 gripped in the fingers of one hand and the vial 2G gripped in the lingers of the other hand. The vial 20 is then turned in a clock-wise direction to cause the male threads 28 to mate up with the female threads 37 until it reaches a point at which the sharpened end 42 of the needle 41 pierces the wall 53 of the plug 25 thus establishing communication between the needle 41 and bore 26 and hence the contents of the vial 20.

In practice, no matter how carefully lled the vial 20 will never be completely filled with a uid 44 but will contain a certain space 54 filled with nothing Ibut air. Prior to injecting the device into the patient the physician or nurse will hold the device shown in FIGURE 8 in an upright position so as to cause the air bubble to be at the top of the vial 20, he then applies pressure on the end 22 of the vial 20 thus forcing the air in the space S4 outwardly through the needle 41 which is continued until at least some small drop of the uid 44 is expelled from the end 43 of the cannula to demonstrate that all of the air has been evacuated.

Thereafter the physician or nurse inserts the cannula tip 43 into the patient. Before proceeding with an injection, however, it is common to aspirate such a device. This is done -by withdrawing by pulling outwardly on the vial 20 as by finger contact with the flange 21 and observing the presence or absence of lblood entering the vial 20.

Assuming the conditions to be correct the physician or nurse then proceeds with the injection of the medicament into the patient which is done simply by pressing on the closed end 22 of the vial 20 to pass the vial over the walls of the cylindrical member 34 until the bottom 22 of the vial 20 contacts the bottom ring 30 of the plug 25. This completes the injection and the device is removed from the patient.

Referring now more particularly to the device shown in FIGURES 4, 5 and 6, there is shown an embodiment of the invention which differs from the embodiment shown in FIGURE 8 in that first a needle cover or needle housing 60 is provided having a press-fit on the boss 39 of the holder 33. This embodiment also differs in that the cylindrical member 34a as its open end is provided with an inturned flange 61. The resilient plug 62 differs radically from the plug 25 of the embodiment shown in FIGURE 8 in that this plug 62 has a cylindrical portion 63 which adjacent its inner end is provided with a plurality of spaced extending lips 64 which as shown in FIGURE 4 in the initial position of the device are adapted to be passed over the inwardly turned ange 61 of the cylindrical member 34a and to engage against the inside of said ange 61.

This contact of the lips 64 with the ange 61 provides an' inner-locking connection which secures the plug 62 in the cylindrical member 34a.

The plug 62 is provided with an outstanding ring 65 and a further series of rings 66, 67 and 68. The plug 62 is provided with a bore 69 comparable to the bore 26 in FIGURE 8 in that it does not pass entirely through the plug 62. The plug 62 is also provided with a second bore 70 aligned with the bore 69 leaving a solid section 71 between the two bores 69 and 70. As before, the vial 20a will contain a uid 44 and an air space 54. The vial 20a is necked-over as at 24a and in fact diers from the vial 2t) only in the absence of the tiange 21.

The above concludes the description of this embodiment of this invention of its condition as shown in FIG- URE 4. It will be noted however, that the ring 66 is disposed outside the necked-over portion 24a and that further the needle 41 is disposed in bore 70 in a sealed condition wherein it is received with a press-fit tosecurely seal this end of the needle aseptically.

Referring now to FIGURE 5, the device is shown in the lirst step which the physician or nurse performs in its use, that is the needle housing 60 has been removed and the physician or nurse has pushed the vial 20a forward to force the plug 62 into the cylindrical portion 34a to a point where flange 61 has engaged and locked ring 65 and that needle 41 has punctured the solid section 71 thus providing communication of the needle 41 with the contents of the vial 26a. It will be noted that the ring 66 provides the necessary resistance by its contact with the necked over portion 24a to assure a lock between Bange 61 and ring 65. Continued forward movement by the physician or nurse of vial 20a causes ring 66 to snap over the neckedover portion 24a and continuing forward movement expells the air 54 at which point the patientmay be injected. The physician or nurse may aspirate by drawing backward on vial 29a because of the inner-lock of the ring and the ange 61. The contents of vial 20a are fully administered by the physician or nurse moving vial 20a in a forward motion as shown in FIGURE 6.

Referring now more particularly to the device shown in FIGURE 7 the similar parts are given similar numbers. The embodiment shown in FIGURE 7 differs Vfrom the embodiment shown in FIGURES 4, 5 and 6 only in that the liange 61a is outwardly disposed as opposed to inwardly disposed flange 61 and that the ring 72 is inwardly disposed as opposed to outwardly disposed lips 64 and that inwardly disposed ring 73 provides the same aspiration lock as outwardly disposed ring 65. The device shown in FIGURE 7 functions exactly as the device shown in FIGURES 4, and 6 with the exception that inwardly disposed rings are contacting an outwardly disposed iiange rather than vice versa.

It will be noted that in embodiments shown in FIG' URES 4, 5, 6 and 7, the needle 41 has its end 42 embedded in a bore 70 which seals the same. It will also be noted that in the embodiment shown in FIGURE 8 that there is no bore in the plug comparable to the bore 70 of the other gures. However, it is within the compass of this invention that the concept of the bore 70 in the plug receiving the end 42 of the needle 41 may be substituted in FIGURE 8 so that the end 42 of the needle 4l is sealed in which case a cap similar to the needle cover 6i) will be used to cover the open end 43 of the needle 41 and the hous ing consisting of the casing 45 and cap 46 may be eliminated. lt is also within the concept of this invention that a plug similar to the plug 25 in that it does not have a bore 70, may be utilized in the embodiment shown in FIGURES 4, 5, 6 and 7, in which case the embodiment shown in FIGURES 4, 5, 6 and 7 would not have the needle cover 60 but would be housed in the casing comprising the casing 45 and cap 46.

It will be appreciated by those skilled in the art that when the device shown in FIGURE 8, having the aspect of not having a sealing bore 70 for the end of the needle 42 is used, then to maintain an aseptic condition a housing such as shown in FIGURES l and 2 is necessary. However, it will be accordingly obvious that when a plug such as shown in FIGURES 4, 5, 6 and 7 having such a bore 70 sealing the end 42 of the needle is utilized then as aseptic condition is here established and that a mere needle cover 6D may complete the package and the outer housing comprising the casing 45 and cap 46 become superuous.

As there is no rictional engagement of the plugs 25 and 62 relied upon, then the bore 70, substantially smaller in diameter than the needle 42, must be used for an aseptic seal of said needle unless the entire unit as in FIGURE 8 is encased in an aseptic sealed outer housing as in FIG URES 1 and 2.

Stated otherwise, the plug 62 or 62a is shown as having a bore 70 which receives the tip 42 of the needle 41 with a press-lit and seals the same. This seal may obviously be accomplished in the embodiment shown in FIGURE 8 by simply putting a bore 70 in the top of the plug 25 somewhat extending the needle 41 so that the tip 42 is again received with a press-ht in the bore 70 now contained in the plug 25, as shown in FIGURE 9. A needle cover such as 69 may then be used instead of housing 45 and cap 46.

While there has been described what is at present considered preferred embodiments of the present invention, it will be appreciated by those skilled in the art that various changes and modifications can be made therein without departing from the essence ofthe invention and it is intended to cover herein all such changes and modilications as come within the true spirit and scope of the appended claims.

I claim:

1. A medicament injector comprising: a cylindrical vial having an open end and a closed end, a resilient plug adapted to be inserted partially into said open end 0f said vial, a plurality of outwardly extending rings upon said plug engaging the walls of said vial with a press lit; a cylindrical holder having an open end and a closed end; a cylindrical member within and spaced from said holder having one end engaging said Closed end of Said holder, said cylindrical member etxending longitudinally of said holder and terminating at an open end within said holder; said holder having a needle extending outwardly from said holder and also inwardly into said holder within said cylindrical member and having a sharpened inner end; interlocking means on said cylindrical member and cooperating interlocking means on said plug; whereby upon insertion of said plug into said holder said vial is first held in an assembled but non-operating position and upon further insertion of said plug into said holder said plug is pierced by said needle and said needle communicates with said vial and said plug is locked securely in said cylindrical member to permit aspiration upon withdrawal of said vial or to permit expulsion ofthe contents of said vial upon exertion of pressure on said vial, said interlocking means on said cylindrical member including an inturned ange on the open end of said cylindrical member, and said cooperating means on said plug including an outwardly extending lip upon said plug adapted to engage the inner side of said inturned flange and hold said injector in assembled condition and another outwardly extending ring on Said plug spaced away from the inner end of said plug from said lip and adapted to engage the inner side of said inturned ange to hold said injector in operating condition.

2. A medicament injector comprising: a cylindrical vial having an open end and a closed end, the walls of said vial at said open end being bent inwardly to form a lip; a resilient plug adapted to be inserted partially into said open end of said Vial; a plurality of outwardly extending rings upon said plug engaging the Walls of said vial with a press tit; a cylindrical holder having an open end and a closed end; a cylindrical member within and spaced from said holder having one end engaging said closed end of said holder, said cylindrical member extending longitudinally of said holder and terminating at an open end within said holder; said holder having a needle extending outwardly from said holder and also inwardly into said holder within said cylindrical member and having a sharpened inner end; interlocking means on said cylindrical member and cooperating interlocking means on said plug; whereby upon insertion of said plug into said holder said vial is iirst held in an assembled but non-operating position and upon further insertion of said plug into Said holder said plug is pierced by said needle and said needle communicates with said vial and said plug is locked securely in said cylindrical member to permit aspiration upon Withdrawal of said vial or to permit expulsion of the contents ot said vial upon exertion of pressure on said vial, and an enlarged ring on said plug engaging the lip at the inturned walls of said vial, said enlarged ring being spaced from said other ring.

3. A medicament injector comprising: a cylindrical vial having an open end and a closed end, the walls of said vial at said open end being bent inwardly to form a lip; a resilient plug adapted to be inserted partially into said open end of said vial, a plurality of outwardly extending rings upon said plug engaging the walls of said vial with a press iit; said plug having a central bore extending partly through said plug; a cylindrical holder having an open end and a closed end; a cylindrical member within and spaced from said holder having one end engaging said closed end or said holder, said cylindrical member extending longitudinally of said holder and terminating at an open end within said holder; said holder having a needle extending outwardly from said holder and also inwardly into said holder within said cylindrical member and having a sharpened inner end; interlocking means on said cylindrical member and cooperating interlocking means on said plug; whereby upon insertion of said plug into said holder said vial is rst held in an assembled but non-operating position and upon further insertion of said plug into said holder said plug is pierced by said needle and said needle communicates with said vial and said plug is locked securely in said cylindrical member to permit aspiration upon withdrawal of said vial or to permit expulsion of the contents of said vial upon exertion of pressure on said vial, said interlocking means on said cylindrical member including an inturned ange on the open end of said cylindrical member, and said cooperating means on said plug including an outwardly extending lip upon said plug adapted to engage the inner side of said inturned flange and hold said injector in assembled Condition and another outwardly extending ring on said plug spaced away from the inner end of said plug from said lip and adapted to engage the inner side of said inturned ange to hold said injector in operating condition, and an enlarged ring on said plug engaging the lip at the inturned walls of said vial, said enlarged ring being spaced from said other ring, said inner end of Said needle in said assembled condition entering said bore and having a press fit therein and piercing said plug when said other outwardly extending ring engages said inner side of said inturned ange.

4. A medicament injector comprising: a cylindrical vial having an open end and a closed end, the walls of said vial at said open end being bent inwardly to form a lip; a resilient plug adapted to be inserted partially into said open end of said vial, a plurality of outwardly extending rings upon said plug engaging the walls of said vial with a press fit; said plug having a central bore extending partly through said plug; a cylindrical holder having an open end and a closed end; a cylindrical member within and spaced from said holder having one end engaging said closed end of said holder, said cylindrical member extending longitudinally of said holder and terminating at an open end within said holder; said holder having a needle extending outwardly from said holder and also inwardly into said holder Within said cylindrical member and having a sharpened inner end; interlocking means on said cylindrical member and cooperating interlocking mcms on said plug; whereby upon insertion of said plug into said holder said vial is first held in an assembled but non-operating position and upon further insertion of said plug into said holder Said plug is pierced by said needle and said needle cornmunicates with said vial and said plug is locked securely in said cylindrical member to permit aspiration upon withdrawal of said vial or to permit expulsion of the contents of said vial upon exertion of pressure on said vial, said interlocking means on said cylindrical member including an inturned flange on the open end of said cylindrical member, and said cooperating means on said plug including an outwardly extending lip upon Vsaid plug adapted to engage the inner side of said inturned ange and hold said injector in assembled condition and another outwardly extendingrring on said plug spaced away from the inner end of Said plug from said lip and adapted to engage the inner side of said inturned flange to hold said injector in operating condition, and an enlarged ring on said plug engaging the lip at the inturned walls of said vial, said enlarged ring being spaced from said other ring, said inner end of said needle in said assembled condition entering said bore and having a press t therein and piercing said plug when said other outwardly extending ring engages said inner side of said inturned Range, and a needle cover having a closed end adapted to enclose the outwardly extending portion of said needle; said holder having a boss upon the end thereof, said needle passing through said boss and said cap having an open end adapted to engage and seal against said boss with a press tit.

5. A medicament injector comprising: a cylindrical vial having an open end and a closed end, a resilient plug adapted to be inserted .partially into said open end of said vial; a plurality of outwardly extending rings upon said plug engaging the walls of said vial with a press fit; a cylindrical holder having an open end and a closed end; a cylindrical member within and spaced from said holder having one end engaging said closed end of said holder, said cylindrical member extending longitudinally of said holder and terminating at an open end within said holder; said holder having a needle extending out- Wardly from said holder and also inwardly into Said holder within said cylindrical member and having a sharp-V ened inner end; interlocking means on said cylindrical member and cooperating interlocking means on said plug; whereby upon insertion of said plug into said holder said vial is iirst held in an assembled but non-operating position and upon further insertion of said plug into said holder said plug is ,pierced by said needle and said needle communicates with said vial and said plug is locked securely in said cylindrical member to permit aspiration upon withdrawal of said vial or to permit expulsion of the contents of said vial upon exertion of pressure on said vial, said interlocking means on said cylindrical member including an outwardly turned ilange on the open end of said cylindrical member and' said cooperating means on said plug including an inwardly extending ange on said plug adapted to engage the inner side of said outwardly turned ange and hold said injector in assembled condition, and an inwardly extending ring on said plug spaced from said inwardly extending ange and adapted to engage the inner side of said outwardly turned ange to hold said injector in operating condition.

References Cited UNITED STATES PATENTS 1,817,003 8/1931 Hein 128--220 2,568,346 9/1951 Lockhart 12S-220 2,586,068 2/ 1952 Lockhart 128-220 2,586,069 2/1952 Lockhart 12S-220 2,922,419 1/1960 Bednarz 12S-218 3,128,766 4/1964 Mizzy 128-220 3,272,322 9/ 1966 Ogle 206-43 RICHARD A. GAUDET, Primary Examiner. D. L. BAKER, Assistant Examiner.

US47441365 1965-07-23 1965-07-23 Hypodermic syringe with vial Expired - Lifetime US3378008A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US47441365 US3378008A (en) 1965-07-23 1965-07-23 Hypodermic syringe with vial
US55129166 US3376866A (en) 1965-07-23 1966-05-19 Medicament injector with attached vial
AU1676467A AU420855B2 (en) 1965-07-23 1967-01-23

Applications Claiming Priority (29)

Application Number Priority Date Filing Date Title
US47441365 US3378008A (en) 1965-07-23 1965-07-23 Hypodermic syringe with vial
US55129166 US3376866A (en) 1965-07-23 1966-05-19 Medicament injector with attached vial
DE19661766675 DE1766675A1 (en) 1965-07-23 1966-07-19 cylindrical vial
NO16398966A NO123141B (en) 1965-07-23 1966-07-19
DE19661491788 DE1491788A1 (en) 1965-07-23 1966-07-19 Injector for drugs
GB3268966A GB1159663A (en) 1965-07-23 1966-07-20 Improvements in or relating to a Medicament Injector
FR70035A FR1487084A (en) 1965-07-23 1966-07-20 An injection of drug
IL2618866A IL26188A (en) 1965-07-23 1966-07-20 Medicament injector with attached vial
GB4992968A GB1159664A (en) 1965-07-23 1966-07-20 Improvements in or relating to Component Parts for Medicament Injectors
GB4993068A GB1159665A (en) 1965-07-23 1966-07-20 Improvements in or relating to Component Parts for Medicament Injectors
NL6610299A NL144835C (en) 1965-07-23 1966-07-21 Medicinal injector.
JP41048148A JPS508273B1 (en) 1965-07-23 1966-07-22
SE1005566A SE334438B (en) 1965-07-23 1966-07-22
CH1362668A CH475758A (en) 1965-07-23 1966-07-22 cylindrical reservoir for medicament injection device
AT703266A AT294304B (en) 1965-07-23 1966-07-22 injection device
CH1063666A CH468195A (en) 1965-07-23 1966-07-22 A drug injection
CH1362568A CH502107A (en) 1965-07-23 1966-07-22 A needle holder for hypodermic injection device
ES0329382A ES329382A1 (en) 1965-07-23 1966-07-22 A drug injection device.
BE684480D BE684480A (en) 1965-07-23 1966-07-22
DK382866A DK119220B (en) 1965-07-23 1966-07-22 Syringe.
FR91538A FR1513617A (en) 1965-07-23 1967-01-18 Needle holder for injection drug delivery device
FR91537A FR1527787A (en) 1965-07-23 1967-01-18 Vial, especially for injection drug delivery device
BE693002D BE693002A (en) 1965-07-23 1967-01-20
BE693003D BE693003A (en) 1965-07-23 1967-01-20
AU1676467A AU420855B2 (en) 1965-07-23 1967-01-23
ES1967129965U ES129965Y (en) 1965-07-23 1967-05-18 A cylindrical holder for drug injectors.
ES1967129964U ES129964Y (en) 1965-07-23 1967-08-30 A cylindrical ampoule.
JP42070282A JPS5137470B1 (en) 1965-07-23 1967-11-02
JP42070283A JPS5137471B1 (en) 1965-07-23 1967-11-02

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US3378008A true US3378008A (en) 1968-04-16

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Family Applications (2)

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US47441365 Expired - Lifetime US3378008A (en) 1965-07-23 1965-07-23 Hypodermic syringe with vial
US55129166 Expired - Lifetime US3376866A (en) 1965-07-23 1966-05-19 Medicament injector with attached vial

Family Applications After (1)

Application Number Title Priority Date Filing Date
US55129166 Expired - Lifetime US3376866A (en) 1965-07-23 1966-05-19 Medicament injector with attached vial

Country Status (14)

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US (2) US3378008A (en)
JP (3) JPS508273B1 (en)
AT (1) AT294304B (en)
AU (1) AU420855B2 (en)
BE (1) BE684480A (en)
CH (1) CH468195A (en)
DE (1) DE1491788A1 (en)
DK (1) DK119220B (en)
ES (2) ES129965Y (en)
FR (1) FR1513617A (en)
IL (1) IL26188A (en)
NL (1) NL144835C (en)
NO (1) NO123141B (en)
SE (1) SE334438B (en)

Cited By (23)

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US3500830A (en) * 1966-08-10 1970-03-17 Philips Corp Injection syringe
US3580251A (en) * 1968-04-12 1971-05-25 Laboraver Sarl Self-injectable ampul
US3659602A (en) * 1970-12-30 1972-05-02 Nosco Plastics Two component syringe
US3664338A (en) * 1970-10-28 1972-05-23 Abbott Lab Cap for a medicament vial
US3696806A (en) * 1968-10-10 1972-10-10 Rhone Poulenc Sa Apparatus for taking samples of liquid
US3739780A (en) * 1972-02-07 1973-06-19 Ims Ltd Saf-t-jet
US3766919A (en) * 1970-12-15 1973-10-23 Nosco Plastics Telescopingly coupled syringe and vial
US3850174A (en) * 1973-03-14 1974-11-26 Becton Dickinson Co Plasma separator assembly
US3885549A (en) * 1972-06-26 1975-05-27 David Thomas Green Apparatus for producing a vacuum in a test tube
US3901402A (en) * 1973-03-14 1975-08-26 Becton Dickinson Co Stopper-piston
US3906947A (en) * 1970-12-15 1975-09-23 Harold S Cloyd Syringe
US3916894A (en) * 1972-09-20 1975-11-04 Nosco Plastics Syringe seals and piston
US3941131A (en) * 1971-10-05 1976-03-02 Ims Limited Device for administration of viscous fluids for the urethal tract
USD245120S (en) * 1974-09-09 1977-07-19 Abbott Laboratories Combined syringe-laryngotracheal cannula
US4041934A (en) * 1976-02-02 1977-08-16 Abbott Laboratories Arterial blood sampling unit
FR2439020A1 (en) * 1978-10-17 1980-05-16 Freisz Jean Needle holder for self injectable syringe - which screws needle into ampoule whilst it is still protected
US4234103A (en) * 1978-03-31 1980-11-18 Baxter Travenol Laboratories, Inc. Diagnostic reagent dispensing bottle
US4341211A (en) * 1981-09-08 1982-07-27 Kline Larry H Lubricating object applicator
WO1985005269A1 (en) * 1984-05-16 1985-12-05 Cosmonor S.A. Process for fabricating a prefilled syringe with unitary dose and device for implementing such process
US5533993A (en) * 1994-10-05 1996-07-09 International Medication Systems, Limited Medication injector with protected cannula and Y-site lockout
EP0827782A2 (en) * 1990-07-04 1998-03-11 Ing. Erich Pfeiffer GmbH Fluid dispenser
US6086560A (en) * 1992-04-17 2000-07-11 Science Incorporated Fluid dispenser with fill adapter
US6090071A (en) * 1992-04-17 2000-07-18 Science Incorporated Fluid dispenser with fill adapter

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US3552387A (en) * 1968-07-16 1971-01-05 Peter A Stevens Combination syringe and vial
US3578195A (en) * 1969-01-16 1971-05-11 Lyoflo Stopper Corp Lyoflo-stopper
BE759374A (en) * 1970-06-08 1971-04-30 Ims Ltd Packaging for medicine
US3972330A (en) * 1970-12-15 1976-08-03 Nosco Plastics, Inc. Syringe
US3994296A (en) * 1972-08-10 1976-11-30 Nosco Plastics, Inc. Syringe
US3923059A (en) * 1971-07-01 1975-12-02 Ims Ltd Medicament injector
US3796359A (en) * 1971-07-07 1974-03-12 P Dick Disposable hypodermic needle destroyer
DK130390C (en) * 1971-10-05 1975-07-14 Ims Ltd
US3841329A (en) * 1972-09-11 1974-10-15 Upjohn Co Compact syringe
US3828779A (en) * 1972-12-13 1974-08-13 Ims Ltd Flex-o-jet
US3869062A (en) * 1973-09-24 1975-03-04 Hoerner Waldorf Corp Vial and syringe carton for emergency drugs
US3942514A (en) * 1974-02-28 1976-03-09 Ims Limited Arterial blood sampling device with indicator
US3980083A (en) * 1975-02-13 1976-09-14 Illinois Tool Works Inc. Medicament infusor unit
US4182326A (en) * 1977-08-26 1980-01-08 Ims Limited Laryngotracheal syringe
US4232669A (en) * 1979-02-15 1980-11-11 Bristol Myers Co. Protective sheath for syringe needle
US4614267A (en) * 1983-02-28 1986-09-30 Abbott Laboratories Dual compartmented container
CH673775A5 (en) * 1987-07-10 1990-04-12 Jacques Verlier
US4850978A (en) * 1987-10-29 1989-07-25 Baxter International Inc. Drug delivery cartridge with protective cover
US5100394A (en) * 1988-01-25 1992-03-31 Baxter International Inc. Pre-slit injection site
US5964785A (en) * 1988-01-25 1999-10-12 Baxter International Inc. Bayonet look cannula for pre-slit y-site
DE68919861D1 (en) * 1988-01-25 1995-01-19 Baxter Int Blunt cannula device.
US5776125A (en) * 1991-07-30 1998-07-07 Baxter International Inc. Needleless vial access device
CA1330412C (en) 1988-07-08 1994-06-28 Steven C. Jepson Pre-slit injection site and tapered cannula
IE62767B1 (en) 1989-03-17 1995-02-22 Baxter Int Pre-slit injection site and tapered cannula
DE69233329D1 (en) * 1991-12-18 2004-04-29 Icu Medical Inc A method for fluid transfer
US5300034A (en) * 1992-07-29 1994-04-05 Minnesota Mining And Manufacturing Company Iv injection site for the reception of a blunt cannula
US5351383A (en) * 1992-07-29 1994-10-04 Minnesota Mining And Manufacturing Company Method of making an injection or sampling site
KR100441231B1 (en) * 1994-06-24 2004-10-12 아이시유메디칼인코오포레이티드 The fluid transport apparatus and method of use
EP0692235A1 (en) * 1994-07-14 1996-01-17 International Medication Systems (U.K.) Ltd. Mixing & dispensing apparatus
US5738663A (en) * 1995-12-15 1998-04-14 Icu Medical, Inc. Medical valve with fluid escape space
US6162206A (en) * 1997-12-23 2000-12-19 Baxter International Inc. Resealable access site
US6830564B2 (en) * 2002-01-24 2004-12-14 Robin Scott Gray Syringe and method of using
LT3045189T (en) * 2011-10-14 2018-06-25 Amgen Inc. Injector and method of assembly
FR3011824B1 (en) * 2013-10-15 2016-05-13 Aptar France Sas Device for packaging a fluid product dispenser.

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US1817003A (en) * 1924-04-26 1931-08-04 George N Hein Hypodermic syringe
US2568346A (en) * 1947-11-24 1951-09-18 Marshall L Lockhart Syringe structure
US2586068A (en) * 1950-04-04 1952-02-19 Marshall L Lockhart Syringe assembly
US2586069A (en) * 1950-04-04 1952-02-19 Marshall L Lockhart Syringe assembly
US2922419A (en) * 1953-12-01 1960-01-26 Becton Dickinson Co Hypodermic syringe assembly
US3128766A (en) * 1962-06-15 1964-04-14 Mizzy Arnold Robert Medicinal syringe
US3272322A (en) * 1964-08-25 1966-09-13 Syn Pak Corp Syringe package

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US2524362A (en) * 1947-07-19 1950-10-03 Arthur E Smith Disposable ampoule syringe
US2497562A (en) * 1947-08-04 1950-02-14 Arthur E Smith Disposable syringe
US3098482A (en) * 1958-01-07 1963-07-23 O'sullivan James Disposable syringe
US3291128A (en) * 1964-01-24 1966-12-13 John G O'neil Hypodermic syringe construction with sealable vent means

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1817003A (en) * 1924-04-26 1931-08-04 George N Hein Hypodermic syringe
US2568346A (en) * 1947-11-24 1951-09-18 Marshall L Lockhart Syringe structure
US2586068A (en) * 1950-04-04 1952-02-19 Marshall L Lockhart Syringe assembly
US2586069A (en) * 1950-04-04 1952-02-19 Marshall L Lockhart Syringe assembly
US2922419A (en) * 1953-12-01 1960-01-26 Becton Dickinson Co Hypodermic syringe assembly
US3128766A (en) * 1962-06-15 1964-04-14 Mizzy Arnold Robert Medicinal syringe
US3272322A (en) * 1964-08-25 1966-09-13 Syn Pak Corp Syringe package

Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3500830A (en) * 1966-08-10 1970-03-17 Philips Corp Injection syringe
US3580251A (en) * 1968-04-12 1971-05-25 Laboraver Sarl Self-injectable ampul
US3696806A (en) * 1968-10-10 1972-10-10 Rhone Poulenc Sa Apparatus for taking samples of liquid
US3664338A (en) * 1970-10-28 1972-05-23 Abbott Lab Cap for a medicament vial
US3906947A (en) * 1970-12-15 1975-09-23 Harold S Cloyd Syringe
US3766919A (en) * 1970-12-15 1973-10-23 Nosco Plastics Telescopingly coupled syringe and vial
US3659602A (en) * 1970-12-30 1972-05-02 Nosco Plastics Two component syringe
US3941131A (en) * 1971-10-05 1976-03-02 Ims Limited Device for administration of viscous fluids for the urethal tract
US3739780A (en) * 1972-02-07 1973-06-19 Ims Ltd Saf-t-jet
US3885549A (en) * 1972-06-26 1975-05-27 David Thomas Green Apparatus for producing a vacuum in a test tube
US3916894A (en) * 1972-09-20 1975-11-04 Nosco Plastics Syringe seals and piston
US3901402A (en) * 1973-03-14 1975-08-26 Becton Dickinson Co Stopper-piston
US3850174A (en) * 1973-03-14 1974-11-26 Becton Dickinson Co Plasma separator assembly
USD245120S (en) * 1974-09-09 1977-07-19 Abbott Laboratories Combined syringe-laryngotracheal cannula
US4041934A (en) * 1976-02-02 1977-08-16 Abbott Laboratories Arterial blood sampling unit
US4234103A (en) * 1978-03-31 1980-11-18 Baxter Travenol Laboratories, Inc. Diagnostic reagent dispensing bottle
FR2439020A1 (en) * 1978-10-17 1980-05-16 Freisz Jean Needle holder for self injectable syringe - which screws needle into ampoule whilst it is still protected
US4341211A (en) * 1981-09-08 1982-07-27 Kline Larry H Lubricating object applicator
WO1985005269A1 (en) * 1984-05-16 1985-12-05 Cosmonor S.A. Process for fabricating a prefilled syringe with unitary dose and device for implementing such process
EP0827782A2 (en) * 1990-07-04 1998-03-11 Ing. Erich Pfeiffer GmbH Fluid dispenser
EP0827782A3 (en) * 1990-07-04 1998-03-18 Ing. Erich Pfeiffer GmbH Fluid dispenser
US6086560A (en) * 1992-04-17 2000-07-11 Science Incorporated Fluid dispenser with fill adapter
US6090071A (en) * 1992-04-17 2000-07-18 Science Incorporated Fluid dispenser with fill adapter
US5533993A (en) * 1994-10-05 1996-07-09 International Medication Systems, Limited Medication injector with protected cannula and Y-site lockout

Also Published As

Publication number Publication date
ES129965Y (en) 1969-07-01
ES129965U (en) 1969-01-16
JPS5137471B1 (en) 1976-10-15
DK119220B (en) 1970-11-30
NL6610299A (en) 1967-01-24
FR1513617A (en) 1968-02-16
ES129964Y (en) 1968-04-16
JPS508273B1 (en) 1975-04-03
CH468195A (en) 1969-02-15
AU420855B2 (en) 1972-01-24
JPS5137470B1 (en) 1976-10-15
US3376866A (en) 1968-04-09
IL26188A (en) 1970-11-30
AU1676467A (en) 1968-01-25
ES129964U (en) 1967-10-16
SE334438B (en) 1971-04-26
NL144835C (en) 1975-07-15
BE684480A (en) 1967-01-23
DE1491788A1 (en) 1970-01-22
NO123141B (en) 1971-10-04
AT294304B (en) 1971-11-25

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